silicic acid


Summary: A hydrated form of silicon dioxide. It is commonly used in the manufacture of TOOTHPASTES and as a stationary phase for CHROMATOGRAPHY.

Top Publications

  1. Armbrust E, Berges J, Bowler C, Green B, Martinez D, Putnam N, et al. The genome of the diatom Thalassiosira pseudonana: ecology, evolution, and metabolism. Science. 2004;306:79-86 pubmed
    ..We identified novel genes for silicic acid transport and formation of silica-based cell walls, high-affinity iron uptake, biosynthetic enzymes for several ..
  2. Grachev M, Annenkov V, Likhoshway Y. Silicon nanotechnologies of pigmented heterokonts. Bioessays. 2008;30:328-37 pubmed publisher
    ..The present review considers possible mechanisms of uptake of silicic acid from the aquatic environment, its transport across the plasmalemma, and intracellular transport and deposition ..
  3. Thamatrakoln K, Hildebrand M. Silicon uptake in diatoms revisited: a model for saturable and nonsaturable uptake kinetics and the role of silicon transporters. Plant Physiol. 2008;146:1397-407 pubmed
    The silicic acid uptake kinetics of diatoms were studied to provide a mechanistic explanation for previous work demonstrating both nonsaturable and Michaelis-Menten-type saturable uptake...
  4. Sumper M, Brunner E. Silica biomineralization in diatoms: the model organism Thalassiosira pseudonana. Chembiochem. 2008;9:1187-94 pubmed publisher
    ..Recent progress, especially with respect to intracellular silicic acid processing, as well as to the natures of the biomolecules involved in diatom cell wall formation, is described...
  5. Quintal Tun F, Muñoz Sánchez J, Ramos Díaz A, Escamilla Bencomo A, Martínez Estevez M, Exley C, et al. Aluminium-induced phospholipid signal transduction pathway in Coffea arabica suspension cells and its amelioration by silicic acid. J Inorg Biochem. 2007;101:362-9 pubmed
    ..These results suggest that Al is capable to exert its effects upon signal transduction as Al((aq))(3+) acting upon a mechanism linked to the phosphoinositide signal transduction pathway...
  6. Linthicum D. Ultrastructural effects of silicic acid on primary lung fibroblasts in tissue culture. Tissue Cell. 2001;33:514-23 pubmed
    ..scanning electron microscopic examination of primary lung fibroblasts exposed in tissue culture to polymeric silicic acid (PSA) revealed profound cellular changes in the cell surface membranes, resulting in rapid endocytosis of ..
  7. Ruttanavut J, Matsumoto Y, Yamauchi K. A fluorescence-based demonstration of intestinal villi and epithelial cell in chickens fed dietary silicic acid powder including bamboo vinegar compound liquid. Histol Histopathol. 2012;27:1333-42 pubmed publisher
    This study investigates the combined effect of silicic acid and bamboo vinegar compound liquid (SPV) on the growth and intestinal histological alterations in poultry...
  8. Perovic Ottstadt S, Wiens M, Schröder H, Batel R, Giovine M, Krasko A, et al. Arginine kinase in the demosponge Suberites domuncula: regulation of its expression and catalytic activity by silicic acid. J Exp Biol. 2005;208:637-46 pubmed
    ..from the demosponge Suberites domuncula express the gene for arginine kinase after exposure to exogenous silicic acid. The deduced sponge arginine kinase sequence displays the two characteristic domains of the ATP:guanido ..
  9. Dickson L, Bull I, Gates P, Evershed R. A simple modification of a silicic acid lipid fractionation protocol to eliminate free fatty acids from glycolipid and phospholipid fractions. J Microbiol Methods. 2009;78:249-54 pubmed publisher
    ..Rather than being eluted from activated silicic acid adsorption chromatographic columns with chloroform, FFAs in standard lipid mixtures appeared only in the two ..

More Information


  1. Sapriel G, Quinet M, Heijde M, Jourdren L, Tanty V, Luo G, et al. Genome-wide transcriptome analyses of silicon metabolism in Phaeodactylum tricornutum reveal the multilevel regulation of silicic acid transporters. PLoS ONE. 2009;4:e7458 pubmed publisher
    ..Analyzing at the global scale the genes networks involved in Si transport and metabolism is critical in order to elucidate Si biomineralization, and to understand diatoms contribution to biogeochemical cycles...
  2. Likhoshway Y, Masyukova Y, Sherbakova T, Petrova D, Grachev M. Detection of the gene responsible for silicic acid transport in chrysophycean algae. Dokl Biol Sci. 2006;408:256-60 pubmed
  3. Lutz K, Gröger C, Sumper M, Brunner E. Biomimetic silica formation: analysis of the phosphate-induced self-assembly of polyamines. Phys Chem Chem Phys. 2005;7:2812-5 pubmed
  4. Kroger N, Deutzmann R, Sumper M. Polycationic peptides from diatom biosilica that direct silica nanosphere formation. Science. 1999;286:1129-32 pubmed
    ..cell walls were shown to generate networks of silica nanospheres within seconds when added to a solution of silicic acid. Silaffins contain covalently modified lysine-lysine elements...
  5. Kwiatek M, Roman S, Fareeduddin A, Pandolfino J, Kahrilas P. An alginate-antacid formulation (Gaviscon Double Action Liquid) can eliminate or displace the postprandial 'acid pocket' in symptomatic GERD patients. Aliment Pharmacol Ther. 2011;34:59-66 pubmed publisher
    ..By creating a low density gel 'raft' that floats on top of gastric contents, alginate-antacid formulations may neutralise the 'acid pocket'...
  6. Mitani N, Ma J, Iwashita T. Identification of the silicon form in xylem sap of rice (Oryza sativa L.). Plant Cell Physiol. 2005;46:279-83 pubmed
    ..6 mM with time. Addition of xylem sap to a solution containing 8 mM Si did not prevent the polymerization of silicic acid. All these results indicate that Si is translocated in the form of monosilicic acid through the xylem and that ..
  7. Calomme M, Geusens P, Demeester N, Behets G, D Haese P, Sindambiwe J, et al. Partial prevention of long-term femoral bone loss in aged ovariectomized rats supplemented with choline-stabilized orthosilicic acid. Calcif Tissue Int. 2006;78:227-32 pubmed
    ..Total lumbar bone mineral density was marginally increased by ch-OSA supplementation. In conclusion, ch-OSA supplementation partially prevents femoral bone loss in the aged OVX rat model...
  8. Thamatrakoln K, Hildebrand M. Approaches for functional characterization of diatom silicic acid transporters. J Nanosci Nanotechnol. 2005;5:158-66 pubmed
    ..This is accomplished through the silicic acid transporters (SITs). The SITs were first identified in the marine pennate diatom Cylindrotheca fusiformis...
  9. Barel A, Calomme M, Timchenko A, De Paepe K, Paepe K, Demeester N, et al. Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails and hair in women with photodamaged skin. Arch Dermatol Res. 2005;297:147-53 pubmed
    ..Oral intake of ch-OSA during the 20 weeks results in a significant positive effect on skin surface and skin mechanical properties, and on brittleness of hair and nails...
  10. Reffitt D, Jugdaohsingh R, Thompson R, Powell J. Silicic acid: its gastrointestinal uptake and urinary excretion in man and effects on aluminium excretion. J Inorg Biochem. 1999;76:141-7 pubmed
    Silicon (Si), as silicic acid, is suggested to be the natural antidote to aluminium (Al) toxicity, and was recently shown to promote the urinary excretion of Al from body stores...
  11. Mandel K, Daggy B, Brodie D, Jacoby H. Review article: alginate-raft formulations in the treatment of heartburn and acid reflux. Aliment Pharmacol Ther. 2000;14:669-90 pubmed
    ..Their unique non-systemic mechanism of action provides rapid and long-duration relief of heartburn and acid reflux symptoms...
  12. Bogdan K, Schenk M. Arsenic in rice (Oryza sativa L.) related to dynamics of arsenic and silicic acid in paddy soils. Environ Sci Technol. 2008;42:7885-90 pubmed
    ..Concentrations of Mn, Fe, As, P, and silicic acid in soil solution and As concentrations in rice straw and polished rice grain were determined...
  13. Reffitt D, Ogston N, Jugdaohsingh R, Cheung H, Evans B, Thompson R, et al. Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro. Bone. 2003;32:127-35 pubmed
    ..In conclusion, orthosilicic acid at physiological concentrations stimulates collagen type 1 synthesis in human osteoblast-like cells and enhances osteoblastic differentiation...
  14. Liu X, Wang S, Feng C. Anti-HepG-2 cell properties of rare earth tungstosilicic polyoxometalates containing 5-fluorouracil. Guang Pu Xue Yu Guang Pu Fen Xi. 2012;32:3309-14 pubmed
    ..The EC50 of FPSW and FSSW is 1.94 x 10(-5) and 1.32 x 10(-5) mol x L(-1) respectively. The therapeutic index of FPSW and FSSW is 0.76 and 1.58 respectively. ..
  15. Fernandez C, Adamson K, Dale M, Cunliffe W. A randomized double-blind study to assess the effects of silicic acid compared to placebo in patients with mild to moderate acne. J Dermatolog Treat. 2005;16:287-94 pubmed
    To establish the efficacy and safety of silicic acid in comparison to placebo in patients with mild to moderate acne vulgaris...
  16. Davis G, Leslie K, Hemenway D. Silicosis in mice: effects of dose, time, and genetic strain. J Environ Pathol Toxicol Oncol. 1998;17:81-97 pubmed
    ..This model should prove valuable for future experimental interventions into the mechanisms of silicosis. ..
  17. Luo X, Guo T, Ou Y, Liu Q. Titanium casting into phosphate bonded investment with zirconite. Dent Mater. 2002;18:512-5 pubmed
    ..The surface of the titanium castings was smooth and without cracks, and the investment on the surface of titanium castings was easily removed. ..
  18. Korhonen E, Rönkkö S, Hillebrand S, Riikonen J, Xu W, Järvinen K, et al. Cytotoxicity assessment of porous silicon microparticles for ocular drug delivery. Eur J Pharm Biopharm. 2016;100:1-8 pubmed publisher
    ..are retained in the eye, releasing drugs at the desired speed until they slowly break down into harmless silicic acid. Here, we have examined the in vitro cytotoxicity of positively and negatively charged thermally oxidized (..
  19. Tisarum R, Chen Y, Dong X, Lessl J, Ma L. Uptake of antimonite and antimonate by arsenic hyperaccumulator Pteris vittata: Effects of chemical analogs and transporter inhibitor. Environ Pollut. 2015;206:49-55 pubmed publisher
    ..We tested the effects of SbIII analogs (arsenite-AsIII, glycerol, silicic acid-Si, and, glucose), antimonate (SbV) analog (phosphate-P), and aquaglyceroporin transporter inhibitor (silver, ..
  20. Farrell S, Barker M, Gerlach R, Putt M, Milleman J. Prevention of lingual calculus formation with daily use of 6% H2O2/2% pyrophosphate whitening strips. J Clin Dent. 2009;20:75-8 pubmed
  21. Gomes F, Moraes J, dos Santos C, Antunes C. [Use of silicon as inductor of the resistance in potato to Myzus persicae (Sulzer) (Hemiptera: Aphididae)]. Neotrop Entomol. 2008;37:185-90 pubmed
    ..Four treatments were tried: foliar fertilization with silicon acid at 1%; soil fertilization with 250 ml silicic acid solution at 1%; foliar fertilization with silicon acid at 1% + soil fertilization with 250 ml silicic acid ..
  22. Barlow A, Zhou X, Barnes J, Hoke S, Eichhold T, Gibb R, et al. Pharmacodynamic and pharmacokinetic effects in gingival crevicular fluid from re-dosing during brushing. Compend Contin Educ Dent. 2004;25:21-7 pubmed
  23. Niu L, Jiao K, Qi Y, Nikonov S, Yiu C, Arola D, et al. Intrafibrillar silicification of collagen scaffolds for sustained release of stem cell homing chemokine in hard tissue regeneration. FASEB J. 2012;26:4517-29 pubmed publisher
    ..Intrafibrillar-silicified collagen scaffolds with sustained SDF-1? release represent a less costly and complex alternative to contemporary cell seeding approaches and provide new therapeutic options for in situ hard tissue regeneration. ..
  24. Zhao X, Mitani N, Yamaji N, Shen R, Ma J. Involvement of silicon influx transporter OsNIP2;1 in selenite uptake in rice. Plant Physiol. 2010;153:1871-7 pubmed publisher
    ..Si as silicic acid did not inhibit the Se uptake from selenite in both rice and yeast (Saccharomyces cerevisiae) at low pHs...
  25. Knight M, Senior L, Nancolas B, Ratcliffe S, Curnow P. Direct evidence of the molecular basis for biological silicon transport. Nat Commun. 2016;7:11926 pubmed publisher
    ..a family of membrane permeases that recognize and actively transport the soluble precursor of biosilica, silicic acid. However, the molecular basis of silicic acid transport remains obscure...
  26. Holmström S, King P, Ryadnov M, Butler M, Mann S, Woolfson D. Templating silica nanostructures on rationally designed self-assembled peptide fibers. Langmuir. 2008;24:11778-83 pubmed publisher
    ..alpha-helix-based peptide fibers of de novo design can promote and direct the deposition of silica from silicic acid solutions...
  27. Kanel S, Greneche J, Choi H. Arsenic(V) removal from groundwater using nano scale zero-valent iron as a colloidal reactive barrier material. Environ Sci Technol. 2006;40:2045-50 pubmed
    ..The effects of competing anions revealed that HCO3-, H4SiO4(0), and H2PO4(2-) are potential interfering agents in the As(V) adsorption reaction. Our results suggest that NZVI is a suitable candidate for As(V) remediation. ..
  28. Henderson M, Perriman A, Robson Marsden H, White J. Protein-poly(silicic) acid interactions at the air/solution interface. J Phys Chem B. 2005;109:20878-86 pubmed
  29. Currie H, Perry C. Silica in plants: biological, biochemical and chemical studies. Ann Bot. 2007;100:1383-9 pubmed
    ..This Botanical Briefing describes the uptake, storage and function of Si, and discusses the role biomolecules play when incorporated into model systems of silica polymerization as well as future directions for research in this field. ..
  30. Bigga E. [Suspended dust from artificial mineral fibers at the work site]. Pneumologie. 1990;44:841-5 pubmed
    ..A measuring procedure matched to the established threshold is employed to measure the concentration of airborne dust at the workplace. ..
  31. Zhao S, Malfait W, Demilecamps A, Zhang Y, Brunner S, Huber L, et al. Strong, Thermally Superinsulating Biopolymer-Silica Aerogel Hybrids by Cogelation of Silicic Acid with Pectin. Angew Chem Int Ed Engl. 2015;54:14282-6 pubmed publisher
    ..Such a design is superior to "neck-limited", classical inorganic aerogels. This new class of materials opens up new perspectives for novel silica-biopolymer nanocomposite aerogels. ..
  32. Kawasaki A, Suge T, Ishikawa K, Ozaki K, Matsuo T, Ebisu S. Ammonium hexafluorosilicate increased acid resistance of bovine enamel and dentine. J Mater Sci Mater Med. 2005;16:461-6 pubmed
    ..Although the acid resistance of the SiF treated teeth was inferior to that of the AgF treated teeth, we consider that SiF has good potential as anticariogenic agent, since it increased acid resistance without changing tooth color. ..
  33. Niles H, Hunter C, Vazquez J, Williams M, Cummins D. Clinical comparison of Colgate Total Advanced Fresh vs a commercially available fluoride breath-freshening toothpaste in reducing breath odor overnight: a multiple-use study. Compend Contin Educ Dent. 2003;24:29-33; quiz 43 pubmed
    ..After a washout period, subjects repeated the same regimen, now using the other test product. The levels of breath VSC were evaluated instrumentally using a gas chromatograph equipped with a flame photometric detector. ..
  34. Suge T, Ishikawa K, Matsuo T. Changes in the crystallinity of hydroxyapatite powder and structure of enamel treated with several concentrations of ammonium hexafluorosilicate. Am J Dent. 2012;25:299-302 pubmed
    ..SEM photographs demonstrated that exposed enamel rods with acid etching were filled with CaF2-like precipitate after SiF treatment regardless of the concentration of SiF solution. ..
  35. Norici A, Bazzoni A, Pugnetti A, Raven J, Giordano M. Impact of irradiance on the C allocation in the coastal marine diatom Skeletonema marinoi Sarno and Zingone. Plant Cell Environ. 2011;34:1666-77 pubmed publisher
    ..Inorganic carbon acquisition, fixation and allocation, and silicic acid and orthophosphate uptake were also studied. The C:P ratio was below the Redfield ratio, especially at LL...
  36. Grachev M, Denikina N, Belikov S, Likhoshvai E, Usol tseva M, Tikhonova I, et al. [Elements of the active center of silicic acid transporters in diatoms]. Mol Biol (Mosk). 2002;36:679-81 pubmed
  37. Hughes N, Mason S, Creeth J, Hara A, Parmar M, Gonzalez Cabezas C. The effect of anti-sensitivity dentifrices on brushing abrasion of eroded dentin in vitro. J Clin Dent. 2008;19:143-6 pubmed
    ..66; p < 0.05) with dentin surface loss. This study demonstrated that the abrasivity of dentifrices can have a significant effect on the wear of eroded dentin in vitro. ..
  38. Davies M, Paice E, Jones S, Leary S, Curtis A, West N. Efficacy of desensitizing dentifrices to occlude dentinal tubules. Eur J Oral Sci. 2011;119:497-503 pubmed publisher
    ..This suggests that strontium acetate pastes may be the most effective at reducing dentine hypersensitivity. ..
  39. Liang B, Fujibayashi S, Fujita H, Ise K, Neo M, Nakamura T. Long-term follow-up study of bioactive bone cement in canine total hip arthroplasty. J Long Term Eff Med Implants. 2006;16:291-9 pubmed
    ..No adverse effects of BABC were observed. BABC maintained the high bioactivity and direct bonding to bone in a canine THA at follow-up of 8 years. ..
  40. Schröder H, Perovic Ottstadt S, Grebenjuk V, Engel S, Müller I, Muller W. Biosilica formation in spicules of the sponge Suberites domuncula: synchronous expression of a gene cluster. Genomics. 2005;85:666-78 pubmed
    ..the synthesis of the siliceous spicules starts intracellularly and is dependent on the concentration of silicic acid. To understand spicule formation, a cluster of genes was isolated...
  41. Feng X, Chen X, Cheng R, Sun L, Zhang Y, He T. Breath malodor reduction with use of a stannous-containing sodium fluoride dentifrice: a meta-analysis of four randomized and controlled clinical trials. Am J Dent. 2010;23 Spec No B:27B-31B pubmed
    ..5% at Hour 27-28. Similar malodor reduction benefits in favor of the stannous-containing dentifrice relative to the negative control were observed for each individual study. ..
  42. Schoelynck J, Bal K, Puijalon S, Meire P, Struyf E. Hydrodynamically mediated macrophyte silica dynamics. Plant Biol (Stuttg). 2012;14:997-1005 pubmed publisher
    ..and Limnophila heterophylla (Roxb.) Benth., to dissolved silicic acid availability and exposure to hydrodynamic stress...
  43. Ramberg P, Lindhe J, Botticelli D, Botticelli A. The effect of a triclosan dentifrice on mucositis in subjects with dental implants: a six-month clinical study. J Clin Dent. 2009;20:103-7 pubmed
    ..The regular use of a dentifrice containing triclosan may reduce the clinical signs of inflammation in the mucosa adjacent to dental implants. ..
  44. Grotheer V, Goergens M, Fuchs P, Dunda S, Pallua N, Windolf J, et al. The performance of an orthosilicic acid-releasing silica gel fiber fleece in wound healing. Biomaterials. 2013;34:7314-27 pubmed publisher
    ..We have demonstrated wound healing-relevant biological activities of a silica-based bio-degradable inorganic material, which might represent a new therapeutic tool in the treatment of chronic wounds. ..
  45. Lech T. Fatal cases of acute suicidal sodium and accidental zinc fluorosilicate poisoning. Review of acute intoxications due to fluoride compounds. Forensic Sci Int. 2011;206:e20-4 pubmed publisher
    ..In addition, in stomach and liver large amounts of silica were detected. In the paper, a review of acute intoxications with various fluoride compounds (17 cases) is also presented. ..
  46. Kucukyilmaz E, Savas S, Akcay M, Bolukbasi B. Effect of silver diamine fluoride and ammonium hexafluorosilicate applications with and without Er:YAG laser irradiation on the microtensile bond strength in sound and caries-affected dentin. Lasers Surg Med. 2016;48:62-9 pubmed publisher
  47. Davies R, Ellwood R, Davies G. The effectiveness of a toothpaste containing triclosan and polyvinyl-methyl ether maleic acid copolymer in improving plaque control and gingival health: a systematic review. J Clin Periodontol. 2004;31:1029-33 pubmed
    ..26 (95% CI: -0.34 to -0.18) and -0.12 (95% CI: -0.17 to -0.08) for the Loe and Silness index and gingivitis severity index, respectively. ..
  48. Pontefract H, Courtney M, Smith S, Newcombe R, Addy M. Development of methods to enhance extrinsic tooth discoloration for comparison of toothpastes. 2. Two-product clinical study. J Clin Periodontol. 2004;31:7-11 pubmed
    ..Using a forced dietary staining method, the data support a tooth stain-inhibitory/-removal action for the experimental formulation, but not the whitening product. ..
  49. Biesbrock A, He T, Walters P, Bartizek R. Clinical evaluation of the effects of a sonic toothbrush with ultrasound waveguide in disrupting plaque with and without bristle contact. Am J Dent. 2008;21:83-7 pubmed
    ..001) greater than plaque removal scores for the non-brushing treatment regimens. ..
  50. Coyle C, Crawford G, Wilkinson J, Thomas S, Bytzer P. Randomised clinical trial: addition of alginate-antacid (Gaviscon Double Action) to proton pump inhibitor therapy in patients with breakthrough symptoms. Aliment Pharmacol Ther. 2017;45:1524-1533 pubmed publisher
    ..15 (0.69-1.91), P=.5939). Adding Gaviscon to PPI reduced breakthrough GERD symptoms but a nearly equal response was observed for placebo. Response to intervention may vary according to whether symptoms are functional in origin. ..
  51. Holme S, Stone N. Compound allergy to Unguentum M. Contact Dermatitis. 2003;49:307-8 pubmed
  52. Petry A. The invention of Crest: a lucky mistake. J Indiana Dent Assoc. 2008;87:31-7 pubmed
  53. Costa R, Moraes J. [Effects of silicon acid and of acibenzolar-S-methyl on Schizaphis graminum (Rondani) (Hemiptera: Aphididae) in wheat plants]. Neotrop Entomol. 2006;35:834-9 pubmed
    ..The addition of silicon acid, mostly in the soil, or of ASM is promising as a control method in the integrated management of aphid in wheat...
  54. Queiroz C, Hara A, Paes Leme A, Cury J. pH-cycling models to evaluate the effect of low fluoride dentifrice on enamel de- and remineralization. Braz Dent J. 2008;19:21-7 pubmed
    ..These data suggest that the models developed in this study were able to evaluate the anti-caries potential of low F dentifrice either on resistance to demineralization or on enhancement of remineralization...
  55. Cresi F, Savino F, Marinaccio C, Silvestro L. Gaviscon for gastro-oesophageal reflux in infants: a poorly effective treatment?. Arch Dis Child. 2006;91:93 pubmed
  56. Ayad F, Stewart B, Zhang Y, Proskin H. A comparison of the efficacy of a triclosan/copolymer/sodium fluoride dentifrice, a stannous fluoride/sodium hexametaphosphate/zinc lactate dentifrice, and a sodium fluoride dentifrice for the control of established supragingival plaque and gingiviti. J Clin Dent. 2010;21:111-6 pubmed
    ..454% stannous fluoride, sodium hexametaphosphate, and zinc lactate, and a commercially available dentifrice containing 0.243% sodium fluoride...
  57. Gawarammana I, Coburn J, Greene S, Dargan P, Jones A. Severe hypokalaemic metabolic alkalosis following ingestion of gaviscon. Clin Toxicol (Phila). 2007;45:176-8 pubmed
    ..Uncommon metabolic abnormalities in the emergency department could be a result of drug overdose due to uncommon agents...
  58. Marciani L, Little S, Snee J, Coleman N, Tyler D, Sykes J, et al. Echo-planar magnetic resonance imaging of Gaviscon alginate rafts in-vivo. J Pharm Pharmacol. 2002;54:1351-6 pubmed
    ..The T2(-1) data showed potential for assessment of dynamic changes in the physicochemical properties of the alginate rafts in-vivo. We conclude that EPI shows great potential in assessing alginate rafts formation in-vivo...
  59. Shcherbakova T, Masiukova I, Safonova T, Petrova D, Vereshchagin A, Minaeva T, et al. [Conservative motif CMLD in silicic acid transport proteins of diatom algae]. Mol Biol (Mosk). 2005;39:303-16 pubmed
    Sequencing of fragments of genes coding for silicic acid transport (SIT) proteins of diatoms of evolutionary distant classes (centric Chaetoceros muelleri Lemmermann, pennate araphid Synedra acus Kützing, pennate raphid Phaeodactylum ..
  60. Saravanan C, Sasikumar S. Bioactive diopside (CaMgSi(2)O(6)) as a drug delivery carrier - a review. Curr Drug Deliv. 2012;9:583-7 pubmed
    ..Compared to other bioceramics diopside is preferable due to its biocompatibility and high mechanical strength...
  61. DeVizio W, Davies R. Rationale for the daily use of a dentifrice containing triclosan in the maintenance of oral health. Compend Contin Educ Dent. 2004;25:54-7 pubmed
    ..No evidence of bacterial resistance or the development of pathogenic or opportunistic bacteria was observed...
  62. Hildebrand M, Wetherbee R. Components and control of silicification in diatoms. Prog Mol Subcell Biol. 2003;33:11-57 pubmed
  63. Schiff T, Delgado E, DeVizio W, Proskin H. A clinical investigation of the efficacy of two dentifrices for the reduction of supragingival calculus formation. J Clin Dent. 2008;19:102-5 pubmed
    ..243% sodium fluoride in a silica base (Crest Cavity Protection Toothpaste) with respect to the reduction of supragingival calculus formation...
  64. Rea S, Brooks R, Best S, Kokubo T, Bonfield W. Proliferation and differentiation of osteoblast-like cells on apatite-wollastonite/polyethylene composites. Biomaterials. 2004;25:4503-12 pubmed
    ..Overall, increased exposure of the glass-ceramic A-W phase in AWPEX through surface polishing, higher volume fraction and/or larger particle size was found to lead to an improved cell response...
  65. Ohsawa K, Neo M, Okamoto T, Tamura J, Nakamura T. In vivo absorption of porous apatite- and wollastonite-containing glass-ceramic. J Mater Sci Mater Med. 2004;15:859-64 pubmed
    ..AW was absorbed continuously, and at six and 12 months the residual material corresponded to about 64 and 30% of the starting material, respectively. Porous AW may therefore be useful as an absorbable bone substitute...
  66. Bolay S, Cakir F, Gurgan S. Effects of toothbrushing with fluoride abrasive and whitening dentifrices on both unbleached and bleached human enamel surface in terms of roughness and hardness: an in vitro study. J Contemp Dent Pract. 2012;13:584-9 pubmed
  67. Doostdar N, Manrique C, Hamill M, Barron A. Synthesis of calcium-silica composites: a route toward an in vitro model system for calcific band keratopathy precipitates. J Biomed Mater Res A. 2011;99:173-83 pubmed publisher
    ..This prompted us to study the reaction of various sources of silicon (fumed silica, silicic acid, and silicone oil) with CaCO(3) under a range of reaction conditions to gain an understanding of the formation ..
  68. Schemehorn B, Moore M, Putt M. Abrasion, polishing, and stain removal characteristics of various commercial dentifrices in vitro. J Clin Dent. 2011;22:11-8 pubmed
  69. Xu T, Deshmukh M, Barnes V, Trivedi H, Du Thumm L, Richter R, et al. Analysis of the antibacterial activity and plaque control benefit of colgate total dentifrice via clinical evaluation and real-time polymerase chain reaction. J Clin Dent. 2005;16:117-22 pubmed
    ..This study analyzed, from a combined clinical and molecular biologic perspective, the antibacterial and antiplaque efficacy of Colgate Total dentifrice (CTD)...
  70. Suberviola Cañas B, Gonzalez Castro A, Castellanos Ortega A, Teja Barbero J, Obeso García T. [Recurrent ventricular fibrillation in magnesium fluosilicate poisoning]. Med Intensiva. 2007;31:344-6 pubmed
  71. Wickett R, Kossmann E, Barel A, Demeester N, Clarys P, Vanden Berghe D, et al. Effect of oral intake of choline-stabilized orthosilicic acid on hair tensile strength and morphology in women with fine hair. Arch Dermatol Res. 2007;299:499-505 pubmed
    ..Oral intake of ch-OSA had a positive effect on tensile strength including elasticity and break load and resulted in thicker hair...
  72. Terezhalmy G, He T, Walters P, Grender J, Biesbrock A. Clinical assessment of extrinsic stain removal efficacy with a new Pulsonic toothbrush. J Clin Dent. 2009;20:71-4 pubmed
    ..To assess the extrinsic stain removal benefit of two different power toothbrushes: an experimental Oral-B Pulsonic rechargeable toothbrush and a positive control Sonicare FlexCare toothbrush...
  73. Yang S, Jia W, Qian Q, Zhou Y, Xia X. Simple approach for efficient encapsulation of enzyme in silica matrix with retained bioactivity. Anal Chem. 2009;81:3478-84 pubmed publisher
    ..The apparent Michaelis-Menten constant is 0.88 mM. The present alcohol-free sol-gel approach is effective for biomolecule encapsulation and is promising for the construction of biosensors, bioelectronics, and biofuel cells...
  74. Barnes V, Richter R, Vandeven M, Xu T, DeVizio W. Clinical investigation of the antiplaque efficacy of a new variant of a commercially available triclosan/copolymer/fluoride dentifrice. J Clin Dent. 2008;19:81-4 pubmed
    ..243% sodium fluoride in a regular silica base (Colgate Winterfresh Gel-Negative Control Dentifrice)...
  75. Sharma S, Soni V, Bellare J. Electrophoretic deposition of nanobiocomposites for orthopedic applications: influence of current density and coating duration. J Mater Sci Mater Med. 2009;20 Suppl 1:S93-100 pubmed publisher
    ..The coating with higher current density and longer coating duration was found to be suitable with improved adhesion and bioactivity for intended metal implants...
  76. Dettmar P, Little S, Baxter T. The effect of omeprazole pre-treatment on rafts formed by reflux suppressant tablets containing alginate. J Int Med Res. 2005;33:301-8 pubmed
    ..950 with 95% confidence intervals of 0.882 and 1.018. Pre-treatment and co-administration with omeprazole has no significant effect on the raft-forming ability of alginate tablets...
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    ..The findings of this study are likely to have utility in applications where controlling gel degradation is desirable, such as in cell delivery or in the controlled release of molecules in the body...
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    ..The purpose of this study was to examine the effects of various product combinations involving brush, paste, rinse, and floss on the prevention of plaque regrowth and gingivitis...
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    ..This study demonstrated the efficacy of the IntelliClean System from Sonicare and Crest in significantly reducing gingivitis and bleeding relative to baseline after 4 weeks of use according to the manufacturer's instructions...
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    ..Through in vitro and in vivo studies, the system and its constituents have been shown to be safe for daily use...
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    ..The adsorption capacities of the CSH/chitosan adsorbent toward heavy metal ions are relatively high compared with those reported in the literature...
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    ..When bio-inspired polymers (polyethyleneimine) are combined with a silicic acid source and phosphate buffer under pH neutral conditions, formation of silicate particles occurs...
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    ..Thus, the results of this double-blind clinical study support the conclusion that the new dentifrice formulation variant is efficacious for the removal of extrinsic tooth stain...
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    So that a possible involvement in the mineralization of dental plaque could be investigated, the effects of silicic acid on calcium phosphate precipitation were assessed in vitro...
  85. Juhasz J, Best S, Brooks R, Kawashita M, Miyata N, Kokubo T, et al. Mechanical properties of glass-ceramic A-W-polyethylene composites: effect of filler content and particle size. Biomaterials. 2004;25:949-55 pubmed
    ..A transition in fracture behaviour from ductile to brittle behaviour was observed in samples containing between 30 and 40 vol% filler...
  86. Boyd P, Law C, Wong C, Nojiri Y, Tsuda A, Levasseur M, et al. The decline and fate of an iron-induced subarctic phytoplankton bloom. Nature. 2004;428:549-53 pubmed
    ..The bloom terminated on day 18, following the depletion of iron and then silicic acid, after which mixed-layer particulate organic carbon (POC) concentrations declined over six days...
  87. Chen X, Ou J, Wei Y, Huang Z, Kang Y, Yin G. Effect of MgO contents on the mechanical properties and biological performances of bioceramics in the MgO-CaO-SiO2 system. J Mater Sci Mater Med. 2010;21:1463-71 pubmed publisher
    ..Furthermore, osteoblasts could adhere, spread and proliferate on these ceramic wafers. Finally, the elongated appearance and minor filopodia of cells on merwinite ceramic were more obvious than the other two ceramics...
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    ..243% sodium fluoride in a silica base (Crest Cavity Protection Toothpaste)...
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    ..This investigation was designed to determine whether the Modified Gingival Margin Plaque Index (MGMPI) method could consistently detect a significant statistical difference between two control commercial products for antiplaque efficacy...