mercuric chloride

Summary

Summary: Mercury chloride (HgCl2). A highly toxic compound that volatizes slightly at ordinary temperature and appreciably at 100 degrees C. It is corrosive to mucous membranes and used as a topical antiseptic and disinfectant.

Top Publications

  1. Sarwar Alam M, Kaur G, Jabbar Z, Javed K, Athar M. Eruca sativa seeds possess antioxidant activity and exert a protective effect on mercuric chloride induced renal toxicity. Food Chem Toxicol. 2007;45:910-20 pubmed
    b>Mercuric chloride (HgCl(2)) is a well-known nephrotoxic agent. Increasing number of evidences suggest the role of oxidative stress in HgCl(2) induced nephrotoxicity...
  2. Fang T, Otto W, Jeffery R, Hunt T, Alison M, Cook H, et al. Exogenous bone marrow cells do not rescue non-irradiated mice from acute renal tubular damage caused by HgCl2, despite establishment of chimaerism and cell proliferation in bone marrow and spleen. Cell Prolif. 2008;41:592-606 pubmed publisher
    ..The aim of this study was to examine this possibility...
  3. Fouda A, Daba M, Dahab G, Sharaf El Din O. Thymoquinone ameliorates renal oxidative damage and proliferative response induced by mercuric chloride in rats. Basic Clin Pharmacol Toxicol. 2008;103:109-18 pubmed publisher
    ..could ameliorate renal oxidative damage and proliferative response induced by mercuric chloride (HgCl2) in rats...
  4. Huang C, Liu S, Hsu C, Lin Shiau S. Neurotoxicological effects of low-dose methylmercury and mercuric chloride in developing offspring mice. Toxicol Lett. 2011;201:196-204 pubmed publisher
    ..The signaling of ROS/Na(+)-K(+)-ATPase/NO(x) plays a crucial role in the underlying mechanism for mercurial compound-induced toxic effects in offspring...
  5. Shi J, Kang F, Wu Q, Lu Y, Liu J, Kang Y. Nephrotoxicity of mercuric chloride, methylmercury and cinnabar-containing Zhu-Sha-An-Shen-Wan in rats. Toxicol Lett. 2011;200:194-200 pubmed publisher
    ..In contrast, the expression of N-cadherin was decreased by HgCl(2). Thus, ZSASW and cinnabar are much less nephrotoxic than HgCl(2) and MeHg, indicating that chemical forms of mercury underlie their disposition and toxicity...
  6. Hansson M, Djerbi M, Rabbani H, Mellstedt H, Gharibdoost F, Hassan M, et al. Exposure to mercuric chloride during the induction phase and after the onset of collagen-induced arthritis enhances immune/autoimmune responses and exacerbates the disease in DBA/1 mice. Immunology. 2005;114:428-37 pubmed
    In susceptible mice, mercuric chloride induces a systemic autoimmune response that is characterized by elevated serum levels of immunoglobulin G1 (IgG1) and immunoglobulin E (IgE), production of anti-nucleolar antibodies (ANolAs) and the ..
  7. Langworthy M, Zhou B, De Caestecker M, Moeckel G, Baldwin H. NFATc1 identifies a population of proximal tubule cell progenitors. J Am Soc Nephrol. 2009;20:311-21 pubmed publisher
    ..To test this, we induced proximal tubular cell (PTC) injury in Balb/c mice and Nfatc1(+/-) mice with mercuric chloride; the PTCs of Nfatc1(+/-) mice demonstrated increased apoptosis, sustained injury, and delayed regeneration...
  8. Zhang Y, Gao D, Bolivar V, Lawrence D. Induction of autoimmunity to brain antigens by developmental mercury exposure. Toxicol Sci. 2011;119:270-80 pubmed publisher
    ..SW mice. Additionally, gender differences in A.SW brain cytokine expressions prior to Hg exposure were eliminated by the Hg exposure...
  9. Wiggers G, Stefanon I, Padilha A, Peçanha F, Vassallo D, Oliveira E. Low nanomolar concentration of mercury chloride increases vascular reactivity to phenylephrine and local angiotensin production in rats. Comp Biochem Physiol C Toxicol Pharmacol. 2008;147:252-60 pubmed
    ..This response is endothelium mediated and involves the reduction of NO bioavailability and the action of reactive oxygen species. The local ACE participates in mercury actions and depends on the angiotensin II generation...

More Information

Publications66

  1. Augusti P, Conterato G, Somacal S, Sobieski R, Spohr P, Torres J, et al. Effect of astaxanthin on kidney function impairment and oxidative stress induced by mercuric chloride in rats. Food Chem Toxicol. 2008;46:212-9 pubmed
    ..Our results indicate that ASX could have a beneficial role against HgCl(2) toxicity by preventing lipid and protein oxidation, changes in the activity of antioxidant enzymes and histopathological changes...
  2. Tao Y, Wang Q, Yuan J, Shen L, Liu C. Effects of vitamin E on mercuric chloride-induced renal interstitial fibrosis in rats and the antioxidative mechanism. Zhong Xi Yi Jie He Xue Bao. 2011;9:201-8 pubmed
    To observe the effects of vitamin E (Vit E) on mercuric chloride (HgCl2)-induced renal interstitial fibrosis (RIF) in rats and discuss its antioxidative mechanism.
  3. Carranza Rosales P, Said Fernandez S, Sepulveda Saavedra J, Cruz Vega D, Gandolfi A. Morphologic and functional alterations induced by low doses of mercuric chloride in the kidney OK cell line: ultrastructural evidence for an apoptotic mechanism of damage. Toxicology. 2005;210:111-21 pubmed
    ..However, detailed studies of morpho-functional alterations induced by mercuric chloride in kidney cell lines are scarce. This work characterizes these alterations in OK cell cultures...
  4. Durante P, Romero F, Pérez M, Chávez M, Parra G. Effect of uric acid on nephrotoxicity induced by mercuric chloride in rats. Toxicol Ind Health. 2010;26:163-74 pubmed publisher
    ..Uric acid did not prevent a decrease in beta-actin signal caused by mercuric chloride, but it promoted a faster recovery when compared to the HgCl(2) alone group...
  5. Santarelli L, Bracci M, Mocchegiani E. In vitro and in vivo effects of mercuric chloride on thymic endocrine activity, NK and NKT cell cytotoxicity, cytokine profiles (IL-2, IFN-gamma, IL-6): role of the nitric oxide-L-arginine pathway. Int Immunopharmacol. 2006;6:376-89 pubmed
    ..L-arginine is also able to reduce glomerular kidney IgG antibodies deposits induced by higher dose of HgCl2 administration...
  6. Di Giusto G, Torres A. Organic anion transporter 5 renal expression and urinary excretion in rats exposed to mercuric chloride: a potential biomarker of mercury-induced nephropathy. Arch Toxicol. 2010;84:741-9 pubmed publisher
    b>Mercuric chloride (HgCl(2)) induces acute kidney injury (AKI) affecting glomerular hemodynamics and, more specifically, the pars recta (S3 segment) of the proximal tubule...
  7. Rao M, Gangadharan B. Antioxidative potential of melatonin against mercury induced intoxication in spermatozoa in vitro. Toxicol In Vitro. 2008;22:935-42 pubmed publisher
    ..Sperm samples were dispersed in RPS medium (pH 6.9) and incubated with mercury in the form of mercuric chloride (MC) at three different concentrations (1 microM, 10 microM, 100 microM), melatonin (MLT) at a concentration ..
  8. Yasutake A, Hachiya N. Accumulation of inorganic mercury in hair of rats exposed to methylmercury or mercuric chloride. Tohoku J Exp Med. 2006;210:301-6 pubmed
    ..Accordingly, a selective quantification of inorganic mercury in human hair may be useful in detecting inorganic mercury exposure...
  9. Kim K, Um S, Chung M, Jung S, Oh J, Kim S, et al. Toxicometabolomics approach to urinary biomarkers for mercuric chloride (HgCl?)-induced nephrotoxicity using proton nuclear magnetic resonance (¹H NMR) in rats. Toxicol Appl Pharmacol. 2010;249:114-26 pubmed publisher
    ..this study was to determine and characterize surrogate biomarkers that can predict nephrotoxicity induced by mercuric chloride (HgCl?) using urinary proton nuclear magnetic resonance (¹H NMR) spectral data...
  10. El Desoky G, Bashandy S, Alhazza I, AL Othman Z, Aboul Soud M, Yusuf K. Improvement of mercuric chloride-induced testis injuries and sperm quality deteriorations by Spirulina platensis in rats. PLoS ONE. 2013;8:e59177 pubmed publisher
    ..Further investigation of therapeutic strategies employing Spirulina against heavy metals toxicity in humans is therefore warranted. ..
  11. Brandão R, Moresco R, Bellé L, Leite M, de Freitas M, Bianchini A, et al. Diphenyl diselenide potentiates nephrotoxicity induced by mercuric chloride in mice. J Appl Toxicol. 2011;31:773-82 pubmed publisher
    ..selenium toxicity, the aim of this work was to extend our previous studies to gain a better understanding of mercuric chloride (HgCl?) + diphenyl diselenide (PhSe)? toxicity. Mice received one daily dose of HgCl? (4...
  12. Izumi Y, Sonoda S, Yoshida H, Danks H, Tsumuki H. Role of membrane transport of water and glycerol in the freeze tolerance of the rice stem borer, Chilo suppressalis Walker (Lepidoptera: Pyralidae). J Insect Physiol. 2006;52:215-20 pubmed
    ..25 M glycerol, but the protection afforded by glycerol is offset by the water-channel inhibitor mercuric chloride. Glycerol in higher concentration (0...
  13. Benz M, Lee S, Kellner L, Döhlemann C, Berweck S. Hyperintense lesions in brain MRI after exposure to a mercuric chloride-containing skin whitening cream. Eur J Pediatr. 2011;170:747-50 pubmed publisher
    ..Although urinary excretion could be enhanced during chelation therapy, signs and symptoms of intoxication could be worsened...
  14. Macphee I, Yagita H, Oliveira D. Blockade of OX40-ligand after initial triggering of the T helper 2 response inhibits mercuric chloride-induced autoimmunity. Immunology. 2006;117:402-8 pubmed
    b>Mercuric chloride (HgCl2)-induced autoimmunity in Brown Norway rats is a spontaneously resolving autoimmune response driven by the activation of T helper type 2 lymphocytes (Th2 cells)...
  15. Philip B, Yi S, Elnitsky M, Lee R. Aquaporins play a role in desiccation and freeze tolerance in larvae of the goldenrod gall fly, Eurosta solidaginis. J Exp Biol. 2008;211:1114-9 pubmed publisher
    ..in freeze tolerance, we froze fat body, midgut and salivary gland tissues in the presence and absence of mercuric chloride, an aquaporin inhibitor...
  16. Yadav N, Rao S, Bhowmik D, Mukhopadhyay A. Bone marrow cells contribute to tubular epithelium regeneration following acute kidney injury induced by mercuric chloride. Indian J Med Res. 2012;136:211-20 pubmed
    ..In critical cases of AKI the only option is renal transplantation. In the present study we evaluated whether bone marrow cells (BMCs) are involved in regeneration of kidney tubules following acute tubular necrosis in the mouse...
  17. Ghosh A, Sil P. A protein from Cajanus indicus Spreng protects liver and kidney against mercuric chloride-induced oxidative stress. Biol Pharm Bull. 2008;31:1651-8 pubmed
    b>Mercuric chloride (HgCl(2)) is a widespread environmental toxin that affects mainly liver and kidney...
  18. Pandey S, Kumar R, Sharma S, Nagpure N, Srivastava S, Verma M. Acute toxicity bioassays of mercuric chloride and malathion on air-breathing fish Channa punctatus (Bloch). Ecotoxicol Environ Saf. 2005;61:114-20 pubmed
    ..96 h) were conducted in flow-through systems to determine the lethal toxicity of a heavy metal compound, mercuric chloride, and an organophosphorus pesticide, malathion, to air-breathing teleost fish, Channa punctatus (Bloch) and ..
  19. Boujbiha M, Hamden K, Guermazi F, Bouslama A, Omezzine A, Kammoun A, et al. Testicular toxicity in mercuric chloride treated rats: association with oxidative stress. Reprod Toxicol. 2009;28:81-9 pubmed publisher
  20. Stacchiotti A, Ricci F, Rezzani R, Li Volti G, Borsani E, Lavazza A, et al. Tubular stress proteins and nitric oxide synthase expression in rat kidney exposed to mercuric chloride and melatonin. J Histochem Cytochem. 2006;54:1149-57 pubmed
    ..A single dose of mercuric chloride (HgCl(2)) can cause acute renal failure in rats, its main target being the proximal tubule...
  21. Gutierrez L, Mazzotti N, Araujo A, Klipel R, Fernandes T, Llesuy S, et al. Peripheral markers of oxidative stress in chronic mercuric chloride intoxication. Braz J Med Biol Res. 2006;39:767-72 pubmed
    ..These results suggest that a preventive treatment with antioxidants would help to avoid oxidative damage in subjects with chronic intoxication...
  22. Holmes E, Cloarec O, Nicholson J. Probing latent biomarker signatures and in vivo pathway activity in experimental disease states via statistical total correlation spectroscopy (STOCSY) of biofluids: application to HgCl2 toxicity. J Proteome Res. 2006;5:1313-20 pubmed
    ..This method provided an unbiased, sensitive approach to biomarker extraction and identification, and showed potential for generating potential novel pathway connectivities...
  23. Furieri L, Galán M, Avendaño M, Garcia Redondo A, Aguado A, Martinez S, et al. Endothelial dysfunction of rat coronary arteries after exposure to low concentrations of mercury is dependent on reactive oxygen species. Br J Pharmacol. 2011;162:1819-31 pubmed publisher
    ..Exposure to mercury is known to increase cardiovascular risk but the underlying mechanisms are not well explored. We analysed whether chronic exposure to low mercury doses affects endothelial modulation of the coronary circulation...
  24. Di Giusto G, Anzai N, Ruiz M, Endou H, Torres A. Expression and function of Oat1 and Oat3 in rat kidney exposed to mercuric chloride. Arch Toxicol. 2009;83:887-97 pubmed publisher
    ..The pharmacological modulation of the expression and/or the function of Oat1 and Oat3 might be an effective therapeutic strategy for reducing the nephrotoxicity of mercury...
  25. Agarwal R, Goel S, Behari J. Detoxification and antioxidant effects of curcumin in rats experimentally exposed to mercury. J Appl Toxicol. 2010;30:457-68 pubmed publisher
    ..to determine its prophylactic/therapeutic role in rats experimentally exposed to mercury (in the from of mercuric chloride-HgCl(2), 12 micromol kg(-1) b.w. single intraperitoneal injection). Curcumin treatment (80 mg kg(-1) b.w...
  26. Badou A, Saoudi A, Dietrich G, Druet E, Druet P, Pelletier L. Mercuric chloride-induced autoimmunity. Curr Protoc Immunol. 2001;Chapter 15:Unit 15.15 pubmed publisher
  27. Naz H, Baig N, Haider S, Haleem D. Subchronic treatment with mercuric chloride suppresses immune response, elicits behavioral deficits and increases brain serotonin and dopamine metabolism in rats. Pak J Pharm Sci. 2008;21:7-11 pubmed
    In view of the neurotoxic effects of mercuric chloride the following study was designed to explore its effects on brain serotonin and dopamine metabolism...
  28. Siddiqi N, Alhomida A. Effect of mercuric chloride on various hydroxyproline fractions in rat serum. Mol Cell Biochem. 2005;271:159-65 pubmed
    b>Mercuric chloride (HgCl2) disturbs the collagen metabolism in the body which is reflected by altered hydroxyproline fractions in the serum...
  29. Sharma M, Sharma A, Kumar A, Kumar M. Spirulina fusiformis provides protection against mercuric chloride induced oxidative stress in Swiss albino mice. Food Chem Toxicol. 2007;45:2412-9 pubmed
    Oxidative stress induced by mercuric chloride (5 mg/kg body weight i.p...
  30. Park E, Park K. Induction of reactive oxygen species and apoptosis in BEAS-2B cells by mercuric chloride. Toxicol In Vitro. 2007;21:789-94 pubmed
    ..In this study, production of reactive oxygen species (ROS) by mercuric chloride (2, 4, 6, and 8 ppm as of mercury) was investigated in cultured human bronchial epithelial cells (BEAS-2B ..
  31. Torres A, Dnyanmote A, Bush K, Wu W, Nigam S. Deletion of multispecific organic anion transporter Oat1/Slc22a6 protects against mercury-induced kidney injury. J Biol Chem. 2011;286:26391-5 pubmed publisher
    ..Eraly, S. A., Vallon, V., Vaughn, D. A., Gangoiti, J. A., Richter, K., Nagle, M., Monte, J. C., Rieg, T., Truong, D. M., Long, J. M., Barshop, B. A., Kaler, G., and Nigam, S. K. (2006) J. Biol. Chem. 281, 5072-5083)...
  32. Augusti P, Conterato G, Somacal S, Einsfeld L, Ramos A, Hosomi F, et al. Effect of lycopene on nephrotoxicity induced by mercuric chloride in rats. Basic Clin Pharmacol Toxicol. 2007;100:398-402 pubmed
  33. Arabi M. Bull spermatozoa under mercury stress. Reprod Domest Anim. 2005;40:454-9 pubmed
    ..This study was designed to evaluate the effect of mercuric chloride (HgCl2) at 50-300 micromol/l concentration range, in vitro, on the sperm membrane and DNA integrity, ..
  34. Boujbiha M, Hamden K, Guermazi F, Bouslama A, Omezzine A, El Feki A. Impairment of spermatogenesis in rats by mercuric chloride: involvement of low 17?-estradiol level in induction of acute oxidative stress. Biol Trace Elem Res. 2011;142:598-610 pubmed publisher
    b>Mercuric chloride (HgCl(2)) has been shown to affect the male reproductive organs, and oxidative stress has been linked with hypospermatogenesis and with male infertility...
  35. Heath J, Abdelmageed Y, Braden T, Nichols A, Steffy D. The effects of chronic mercuric chloride ingestion in female Sprague-Dawley rats on fertility and reproduction. Food Chem Toxicol. 2009;47:1600-5 pubmed publisher
    Thirty-days-old female rats were chronically exposed, for 60 days, to 1or 2mg/kg/day of mercuric chloride or an equivalent volume of water, via gavage. At 90 days of age they were mated with unexposed males...
  36. Siddiqi N, Alhomida A. Effect of mercuric chloride on urinary excretion of free hydroxyproline. Med Sci Monit. 2006;12:BR95-101 pubmed
    The present study was undertaken to study the effect of mercuric chloride (HgCl2) on the collagen metabolism in rats and the protective effect of 2, 3-dimercapto-1-propane sulfonic acid (DMPS) in HgCl2-treated rats.
  37. Wu Z, Pearson A, Oliveira D. Characterization of cis-regulatory elements conferring mercury-induced interleukin-4 gene expression in rat mast cells: a role for signal transducer and activator of transcription 6 and TATA box binding sites. Immunology. 2009;127:530-8 pubmed publisher
    We have previously shown that oxidative stress is involved in the pathogenesis of a mercuric chloride (HgCl(2))-induced, T helper type 2 (Th2)-driven autoimmune syndrome in Brown Norway (BN) rats...
  38. Stacchiotti A, Li Volti G, Lavazza A, Rezzani R, Rodella L. Schisandrin B stimulates a cytoprotective response in rat liver exposed to mercuric chloride. Food Chem Toxicol. 2009;47:2834-40 pubmed publisher
    ..We analyzed whether Sch B could protect rat liver against mercuric chloride (HgCl2) intake by analyzing stress proteins and histopathological changes...
  39. Levin M, Lemcoff J, Cohen S, Kapulnik Y. Low air humidity increases leaf-specific hydraulic conductance of Arabidopsis thaliana (L.) Heynh (Brassicaceae). J Exp Bot. 2007;58:3711-8 pubmed
    ..The rapid hydraulic response and the influence of mercury raise the possibility that an alternative response to atmospheric dryness is increased K modulated by aquaporins...
  40. Lu Y, Yan J, Wu Q, Shi J, Liu J, Shi J. Realgar- and cinnabar-containing an-gong-niu-huang wan (AGNH) is much less acutely toxic than sodium arsenite and mercuric chloride. Chem Biol Interact. 2011;189:134-40 pubmed publisher
    ..question, the acute toxicity of AGNH, realgar and cinnabar were compared to sodium arsenite (NaAsO?) and mercuric chloride (HgCl?). Mice were administrated orally AGNH at 1, 3 and 6g/kg. AGNH at 3g/kg contains 2...
  41. Ababneh F, Scott S, Al Reasi H, Lean D. Photochemical reduction and reoxidation of aqueous mercuric chloride in the presence of ferrioxalate and air. Sci Total Environ. 2006;367:831-9 pubmed
    ..UVA irradiation of aqueous acidic mercuric chloride (pH 1-4) in the presence of an excess of ferrioxalate results in partial reduction of the mercuric ion to ..
  42. Orct T, Blanusa M, Lazarus M, Varnai V, Kostial K. Comparison of organic and inorganic mercury distribution in suckling rat. J Appl Toxicol. 2006;26:536-9 pubmed
    ..However, the brain and blood concentrations of mercury were higher in the thiomersal exposed group. These results need to be clarified by additional data on the kinetic pathways of ethylmercury compared with inorganic mercury...
  43. Hemdan N, Lehmann I, Wichmann G, Lehmann J, Emmrich F, Sack U. Immunomodulation by mercuric chloride in vitro: application of different cell activation pathways. Clin Exp Immunol. 2007;148:325-37 pubmed
    ..MoAb: anti-CD3/-CD28/-CD40) or heat-killed Salmonella enterica serovar Enteritidis (hk-SE), exposed to mercuric chloride (HgCl2) for 24 h...
  44. Brandão R, Borges L, Nogueira C. Concomitant administration of sodium 2,3-dimercapto-1-propanesulphonate (DMPS) and diphenyl diselenide reduces effectiveness of DMPS in restoring damage induced by mercuric chloride in mice. Food Chem Toxicol. 2009;47:1771-8 pubmed publisher
    ..Mice were exposed to mercuric chloride (HgCl(2)) (1mg/kg, subcutaneously) for two weeks. After that, mice received (PhSe)(2) (15...
  45. Savage D, Stroud R. Structural basis of aquaporin inhibition by mercury. J Mol Biol. 2007;368:607-17 pubmed
    ..Thus, we elucidate a steric inhibition mechanism for this important class of channels by mercury...
  46. Fang T, Otto W, Rao J, Jeffery R, Hunt T, Alison M, et al. Haematopoietic lineage-committed bone marrow cells, but not cloned cultured mesenchymal stem cells, contribute to regeneration of renal tubular epithelium after HgCl 2 -induced acute tubular injury. Cell Prolif. 2008;41:575-91 pubmed publisher
    ..The aim of this study was to examine which fraction of BMCs, haematopoietic lineage marrow cells (HLMCs) or mesenchymal stem cells (MSCs), are effective...
  47. Wiggers G, Pecanha F, Briones A, Perez Giron J, Miguel M, Vassallo D, et al. Low mercury concentrations cause oxidative stress and endothelial dysfunction in conductance and resistance arteries. Am J Physiol Heart Circ Physiol. 2008;295:H1033-H1043 pubmed publisher
    ..These findings offer further evidence that mercury, even at low concentrations, is an environmental risk factor for cardiovascular disease...
  48. Yen T, Alison M, Cook H, Jeffery R, Otto W, Wright N, et al. The cellular origin and proliferative status of regenerating renal parenchyma after mercuric chloride damage and erythropoietin treatment. Cell Prolif. 2007;40:143-56 pubmed
    ..we have sought to establish the cellular origin and proliferative status of the renal parenchyma as it regenerates after damage induced by mercuric chloride, with or without erythropoietin treatments, that might alter the response.
  49. Yang H, Xu Z, Liu W, Deng Y, Xu B. The protective role of procyanidins and lycopene against mercuric chloride renal damage in rats. Biomed Environ Sci. 2011;24:550-9 pubmed publisher
    This study aims to investigate the protection of procyanidins and lycopene from the renal damage induced by mercuric chloride.
  50. Stoiber T, Degen G, Bolt H, Unger E. Interaction of mercury(II) with the microtubule cytoskeleton in IMR-32 neuroblastoma cells. Toxicol Lett. 2004;151:99-104 pubmed
    ..This could be due to disturbed information transfer processes depending on an intact microtubule system. ..
  51. Preston G, Carroll T, Guggino W, Agre P. Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein. Science. 1992;256:385-7 pubmed
    ..CHIP28 RNA exhibited increased osmotic water permeability; this was reversibly inhibited by mercuric chloride, a known inhibitor of water channels...
  52. Zalups R. Renal accumulation and intrarenal distribution of inorganic mercury in the rabbit: effect of unilateral nephrectomy and dose of mercuric chloride. J Toxicol Environ Health. 1991;33:213-28 pubmed
    The effects of unilateral nephrectomy and dose of mercuric chloride on the short-term renal accumulation and intrarenal distribution of inorganic mercury were studied in the rabbit...
  53. Khan A, Atkinson A, Graham T, Thompson S, Ali S, Shireen K. Effects of inorganic mercury on reproductive performance of mice. Food Chem Toxicol. 2004;42:571-7 pubmed
    Effects of mercuric chloride (MC) on the reproductive performance of mice were evaluated. Both male and female mice were divided into four groups that were subsequently exposed to 0.00, 0.25, 0.50, and 1.00 mg/kg/day of MC, respectively...
  54. Ramalingam V, Vimaladevi V, Rajeswary S, Suryavathi V. Effect of mercuric chloride on circulating hormones in adult albino rats. J Environ Biol. 2003;24:401-4 pubmed
    The effect of mercuric chloride at two different doses, 0.5 mg/kg body weight (low dose), 1 mg/kg body weight (high dose), for 30 days, was seen on the circulating hormones in the mature male albino rats...
  55. Wang Z, Chen J, Wang S, Moeckel G, Harris R. Importance of functional EGF receptors in recovery from acute nephrotoxic injury. J Am Soc Nephrol. 2003;14:3147-54 pubmed
    ..These studies indicate that functional EGFR activity is an essential component of the kidney's ability to recover from acute injury and that EGFR may regulate genes involved in growth, repair, and cell survival in the kidney...
  56. Shimojo N, Kumagai Y, Nagafune J. Difference between kidney and liver in decreased manganese superoxide dismutase activity caused by exposure of mice to mercuric chloride. Arch Toxicol. 2002;76:383-7 pubmed
    ..hepatic enzyme activity of an antioxidant protein manganese superoxide dismutase (Mn-SOD) after exposure to mercuric chloride (HgCl(2)) were examined in ICR mice. Subcutaneous administration of HgCl(2) (0...
  57. Wu Z, Turner D, Oliveira D. Antioxidants inhibit mercuric chloride-induced early vasculitis. Int Immunol. 2002;14:267-73 pubmed
    In the Brown Norway (BN) rat, mercuric chloride (HgCl(2)) induces a T(h)2-dominated autoimmune syndrome which includes an early phase of mast cell-dependent vasculitis...