human genome project

Summary

Summary: A coordinated effort of researchers to map (CHROMOSOME MAPPING) and sequence (SEQUENCE ANALYSIS, DNA) the human GENOME.

Top Publications

  1. ncbi Mapping and sequencing information: the social context for the genomics revolution
    Miguel García-Sancho
    Centre for the History of Science, Imperial College, London, United Kingdom
    Endeavour 31:18-23. 2007
  2. ncbi The sequence of the human genome
    J C Venter
    Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
    Science 291:1304-51. 2001
  3. pmc Segmental duplications: organization and impact within the current human genome project assembly
    J A Bailey
    Department of Genetics and Center for Human Genetics, Case Western Reserve School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    Genome Res 11:1005-17. 2001
  4. pmc Sequencing and analysis of an Irish human genome
    Pin Tong
    Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Genome Biol 11:R91. 2010
  5. ncbi Human genome. A low number wins the GeneSweep Pool
    Elizabeth Pennisi
    Science 300:1484. 2003
  6. pmc On the immortality of television sets: "function" in the human genome according to the evolution-free gospel of ENCODE
    Dan Graur
    Department of Biology and Biochemistry, University of Houston, TX, USA
    Genome Biol Evol 5:578-90. 2013
  7. ncbi A vision for the future of genomics research
    Francis S Collins
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 422:835-47. 2003
  8. ncbi Human genome sequencing using unchained base reads on self-assembling DNA nanoarrays
    Radoje Drmanac
    Complete Genomics, Inc, 2071 Stierlin Court, Mountain View, CA 94043, USA
    Science 327:78-81. 2010
  9. ncbi The DNA sequence of human chromosome 22
    I Dunham
    Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Nature 402:489-95. 1999
  10. pmc The diploid genome sequence of an individual human
    Samuel Levy
    J Craig Venter Institute, Rockville, Maryland, USA
    PLoS Biol 5:e254. 2007

Detail Information

Publications256 found, 100 shown here

  1. ncbi Mapping and sequencing information: the social context for the genomics revolution
    Miguel García-Sancho
    Centre for the History of Science, Imperial College, London, United Kingdom
    Endeavour 31:18-23. 2007
    ..The application of computing to DNA during the first half of the 1980s was crucial for this integration, fostering the emergence of genomics and ultimately the Human Genome Project.
  2. ncbi The sequence of the human genome
    J C Venter
    Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA
    Science 291:1304-51. 2001
    ..Less than 1% of all SNPs resulted in variation in proteins, but the task of determining which SNPs have functional consequences remains an open challenge...
  3. pmc Segmental duplications: organization and impact within the current human genome project assembly
    J A Bailey
    Department of Genetics and Center for Human Genetics, Case Western Reserve School of Medicine and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    Genome Res 11:1005-17. 2001
    ..The identification and characterization of these highly duplicated regions represents an important step in the complete sequencing of a human reference genome...
  4. pmc Sequencing and analysis of an Irish human genome
    Pin Tong
    Conway Institute, University College Dublin, Belfield, Dublin 4, Ireland
    Genome Biol 11:R91. 2010
    ....
  5. ncbi Human genome. A low number wins the GeneSweep Pool
    Elizabeth Pennisi
    Science 300:1484. 2003
  6. pmc On the immortality of television sets: "function" in the human genome according to the evolution-free gospel of ENCODE
    Dan Graur
    Department of Biology and Biochemistry, University of Houston, TX, USA
    Genome Biol Evol 5:578-90. 2013
    ..The ENCODE results were predicted by one of its authors to necessitate the rewriting of textbooks. We agree, many textbooks dealing with marketing, mass-media hype, and public relations may well have to be rewritten...
  7. ncbi A vision for the future of genomics research
    Francis S Collins
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 422:835-47. 2003
  8. ncbi Human genome sequencing using unchained base reads on self-assembling DNA nanoarrays
    Radoje Drmanac
    Complete Genomics, Inc, 2071 Stierlin Court, Mountain View, CA 94043, USA
    Science 327:78-81. 2010
    ..The high accuracy, affordable cost of $4400 for sequencing consumables, and scalability of this platform enable complete human genome sequencing for the detection of rare variants in large-scale genetic studies...
  9. ncbi The DNA sequence of human chromosome 22
    I Dunham
    Sanger Centre, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Nature 402:489-95. 1999
    ..4 megabases, contains at least 545 genes and 134 pseudogenes, and provides the first view of the complex chromosomal landscapes that will be found in the rest of the genome...
  10. pmc The diploid genome sequence of an individual human
    Samuel Levy
    J Craig Venter Institute, Rockville, Maryland, USA
    PLoS Biol 5:e254. 2007
    ..These data depict a definitive molecular portrait of a diploid human genome that provides a starting point for future genome comparisons and enables an era of individualized genomic information...
  11. ncbi A sample selection strategy for next-generation sequencing
    Chul Joo Kang
    Department of Preventive Medicine, Keck School of Medicine, USC, Los Angeles, California, USA
    Genet Epidemiol 36:696-709. 2012
    ..We then describe a variation on our algorithm that is more focused on detecting rarer variants. We demonstrate the performance of our algorithm using simulated data and data from the 1000 Genomes Project...
  12. ncbi The Human Genome Diversity Project: past, present and future
    L Luca Cavalli-Sforza
    L Luca Cavalli Sforza is at the Genetics Department, Stanford Medical School, Stanford, California 94305, USA
    Nat Rev Genet 6:333-40. 2005
    The Human Genome Project, in accomplishing its goal of sequencing one human genome, heralded a new era of research, a component of which is the systematic study of human genetic variation...
  13. ncbi "What are they going to do with the information?" Latino/Latina and African American perspectives on the Human Genome Project
    Amy Schulz
    Department of Health Behavior and Health Education, University of Michigan School of Public Health, Ann Arbor 48109 2029, USA
    Health Educ Behav 30:151-69. 2003
    ..In addition, they present strategies for achieving a more equitable distribution of risks and benefits from genetic research and technology suggested by participants in these focus groups...
  14. ncbi Human evolution and its relevance for genetic epidemiology
    Luigi Luca Cavalli-Sforza
    Genetics Department, Stanford University Medical School, Stanford, California 94305 5120, USA
    Annu Rev Genomics Hum Genet 8:1-15. 2007
    ..I have made no attempt to give a general bibliography, not even of results from the HGDP, since most authors' conclusions are still unpublished. Citations are limited to very few general concepts and articles discussed in this preface...
  15. ncbi The Human Genome Project and the future of diagnostics, treatment and prevention
    G J B van Ommen
    Department of Human and Clinical Genetics, Leiden University Medical Center, The Netherlands
    J Inherit Metab Dis 25:183-8. 2002
    The Human Genome Project, the mapping of our 30,000-50,000 genes and the sequencing of all of our DNA, will have major impact on biomedical research and the whole of therapeutic and preventive health care...
  16. pmc What does our genome encode?
    John A Stamatoyannopoulos
    Departments of Genome Sciences and Medicine, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Genome Res 22:1602-11. 2012
    ..Finally, I consider prospects for the future, including maximizing the accuracy, completeness, and utility of ENCODE data for the community...
  17. pmc The thousand-dollar genome. Genetic brinkmanship or personalized medicine?
    Howard Wolinsky
    EMBO Rep 8:900-3. 2007
  18. pmc Inferring human colonization history using a copying model
    Garrett Hellenthal
    Department of Statistics, University of Oxford, Oxford, United Kingdom
    PLoS Genet 4:e1000078. 2008
    ..A detailed depiction of the peopling of the world is available in animated form...
  19. ncbi The Human Genome Project: lessons from large-scale biology
    Francis S Collins
    National Human Genome Research Institute, National Institutes of Health, Building 31, Room 4B09, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Science 300:286-90. 2003
  20. ncbi Ethical aspects of genome diversity research: genome research into cultural diversity or cultural diversity in genome research?
    Ilhan Ilkilic
    Institute for History, Philosophy and Ethics of Medicine, Johannes Gutenberg University, Mainz, Germany
    Med Health Care Philos 12:25-34. 2009
    ....
  21. pmc Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions
    France Denoeud
    Grup de Recerca en Informàtica Biomèdica, Institut Municipal d Investigació Mèdica Universitat Pompeu Fabra, 08003 Barcelona, Catalonia, Spain
    Genome Res 17:746-59. 2007
    ....
  22. doi Genomics sizes up
    Jane Qiu
    Nature 451:234. 2008
  23. pmc Sickle cell screening policies as portent: how will the human genome project affect public sector genetic services?
    D D Phoenix
    Department of Health Sciences, College of Nursing, Clemson University, South Carolina, USA
    J Natl Med Assoc 87:807-12. 1995
    The Human Genome Project holds much promise for providing dramatic improvements in our understanding of and means to diagnose and treat many diseases...
  24. ncbi [The Human Genome Project, genetic viability and genetic epidemiology]
    Krisztina Hagymasi
    Semmelweis Egyetem, Általános Orvostudományi Kar, II Belgyógyászati Klinika, Budapest
    Orv Hetil 146:2575-80. 2005
    The goal of the Human Genome Project to elucidate the complete sequence of the human genome has been achieved...
  25. ncbi What is a gene, post-ENCODE? History and updated definition
    Mark B Gerstein
    Program in Computational Biology and Bioinformatics, Yale University, New Haven, Connecticut 06511, USA
    Genome Res 17:669-81. 2007
    ..It also manifests how integral the concept of biological function is in defining genes...
  26. ncbi Human monogenic disorders - a source of novel drug targets
    Ryan R Brinkman
    British Columbia Cancer Research Centre, University of British Columbia, Vancouver, British Columbia V5Z 1C3, Canada
    Nat Rev Genet 7:249-60. 2006
    ..A large fraction of the human gene repertoire remains phenotypically uncharacterized, and is likely to encode many unanticipated and novel phenotypes that will be of interest to pharmaceutical and biotechnological drug developers...
  27. ncbi Scoliosis and the human genome project
    Martha C Hawes
    Department of Plant Sciences, Division of Plant Pathology and Microbiology, Bio5 Institute of Life Sciences, University of Arizona, Tucson, AZ 85721, USA
    Stud Health Technol Inform 135:97-111. 2008
    ..These data can be used to identify children at high risk for developing spinal deformities and to design strategies for prevention...
  28. ncbi Human genome diversity: what about the other human genome project?
    H T Greely
    Stanford Law School, Stanford, California 94305 8610, USA
    Nat Rev Genet 2:222-7. 2001
    Although the Human Genome Project has been successful, the Human Genome Diversity Project, proposed in 1991, has so far failed to thrive...
  29. pmc A robust approach to identifying tissue-specific gene expression regulatory variants using personalized human induced pluripotent stem cells
    Je Hyuk Lee
    Department of Genetics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Genet 5:e1000718. 2009
    ..We show that our approach to mapping cis-regulatory variants reduces in vitro experimental noise and reveals additional tissue-specific variants using skin-derived human iPS cells...
  30. ncbi Family physicians' perspectives on genetics and the human genome project
    M D Fetters
    Department of Family Medicine, University of Michigan Medical Center, University of Michigan, Ann Arbor 48109 0708, USA
    Clin Genet 56:28-34. 1999
    ..the study was to determine family physicians' attitudes and beliefs about human genetics research and the human genome project (HGP). The design of the study involved qualitative, semi-structured interviews...
  31. pmc Personal genomes in progress: from the human genome project to the personal genome project
    Jeantine E Lunshof
    European Centre for Public Health Genomics, FHML, Maastricht University, Maastricht, The Netherlands
    Dialogues Clin Neurosci 12:47-60. 2010
    ..This article examines the Personal Genome Project's effort to develop a GET database as a public genomics resource broadly accessible to both researchers and research participants, while pursuing the highest standards in research ethics...
  32. doi Principal component analysis of genetic data
    David Reich
    Nat Genet 40:491-2. 2008
  33. pmc Assembly of the working draft of the human genome with GigAssembler
    W J Kent
    Department of Biology, University of California at Santa Cruz, Santa Cruz, California 95064, USA
    Genome Res 11:1541-8. 2001
    ..7 billion base pairs and covering an estimated 88% of the genome that has been used for several recent studies of the genome. Here we describe the algorithm used by GigAssembler...
  34. pmc Genetics. Was the Human Genome Project worth the effort?
    Stephen P Daiger
    Human Genetics Center, University of Texas Health Sciences Center, Houston, TX 77030, USA
    Science 308:362-4. 2005
  35. ncbi Genomes for all
    George M Church
    Harvard Medical School, USA
    Sci Am 294:46-54. 2006
  36. ncbi The human genome project is complete. How do we develop a handle for the pump?
    Julian Little
    Am J Epidemiol 157:667-73. 2003
  37. ncbi The Human Genome Project. Revealing the shared inheritance of all humankind
    F S Collins
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 2152, USA
    Cancer 91:221-5. 2001
    The information derived from the Human Genome Project, an international effort to decode the information embedded in the human genome, will revolutionize the practice of medicine in the 21st century by providing the tools to determine the ..
  38. pmc Whole-genome shotgun assembly and comparison of human genome assemblies
    Sorin Istrail
    Applied Biosystems, 45 West Gude Drive, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 101:1916-21. 2004
    ..The Celera results provide more order and orientation, and the consortium sequence provides better coverage of exact and nearly exact repeats...
  39. ncbi Toward the 1,000 dollars human genome
    Simon T Bennett
    Solexa Limited, Chesterford Research Park, Little Chesterford, Essex CB10 1XL, UK
    Pharmacogenomics 6:373-82. 2005
    ..A new sequencing paradigm based on single molecules will be faster, cheaper and more sensitive, and will permit routine analysis at the whole-genome level...
  40. ncbi Initial sequencing and analysis of the human genome
    E S Lander
    Whitehead Institute for Biomedical Research, Center for Genome Research, Cambridge, Massachusetts 02142, USA
    Nature 409:860-921. 2001
    ..We also present an initial analysis of the data, describing some of the insights that can be gleaned from the sequence...
  41. ncbi Implications of the Human Genome Project for medical science
    F S Collins
    National Human Genome Research Institute, National Institutes of Health, 31 Center Dr, MSC 2152, Bldg 31 Room 4B09, Bethesda, MD 20892 2152, USA
    JAMA 285:540-4. 2001
    ..Genomic medicine holds the ultimate promise of revolutionizing the diagnosis and treatment of many illnesses...
  42. ncbi Structural genomics: beyond the human genome project
    S K Burley
    Howard Hughes Medical Institute, 1230 York Avenue, New York, New York 10021, USA
    Nat Genet 23:151-7. 1999
    With access to whole genome sequences for various organisms and imminent completion of the Human Genome Project, the entire process of discovery in molecular and cellular biology is poised to change...
  43. pmc Genetic studies of human diversity in East Asia
    Feng Zhang
    Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, People s Republic of China
    Philos Trans R Soc Lond B Biol Sci 362:987-95. 2007
    ..e. Central Asia, the Sub-continent, America and the Pacific Islands), the origin of Sino-Tibetan populations and expansion of the Chinese...
  44. pmc Origins of the human genome project: why sequence the human genome when 96% of it is junk?
    Paul Berg
    Stanford University Medical Center, Stanford, CA 94305, USA
    Am J Hum Genet 79:603-5. 2006
  45. ncbi New goals for the U.S. Human Genome Project: 1998-2003
    F S Collins
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Science 282:682-9. 1998
    The Human Genome Project has successfully completed all the major goals in its current 5-year plan, covering the period 1993-98. A new plan, for 1998-2003, is presented, in which human DNA sequencing will be the major emphasis...
  46. ncbi The human genome project and its impact on psychiatry
    W Maxwell Cowan
    National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Annu Rev Neurosci 25:1-50. 2002
    ....
  47. ncbi Technology-specific error signatures in the 1000 Genomes Project data
    Michael Nothnagel
    Institute of Medical Informatics and Statistics, Christian Albrechts University, Brunswiker Str 10, 24105 Kiel, Germany
    Hum Genet 130:505-16. 2011
    ..Our study thus highlights that different NGS platforms suit different practical applications differently well, and that NGS-based studies require stringent data quality control for their results to be valid...
  48. ncbi Comparative genomics: the key to understanding the Human Genome Project
    M S Clark
    Fugu Landmark Mapping Project, HGMP Resource Centre, Hinxton, Cambridge, UK
    Bioessays 21:121-30. 1999
    ..Comparative genomics (with model organisms), once the poor relation of the human genome project, is starting to provide the key to unlock the DNA code.
  49. ncbi The human genome project and novel aspects of cytochrome P450 research
    Magnus Ingelman-Sundberg
    Division of Molecular Toxicology, IMM, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Toxicol Appl Pharmacol 207:52-6. 2005
    ..Among the genes discovered by initiatives in the human genome project are CYP2R1, CYP2W1, CYP2S1, CYP2U1 and CYP3A43, the latter apparently encoding a pseudoenzyme...
  50. pmc To reveal the genomes
    Robert L Sinsheimer
    Department of Molecular, Cellular, and Developmental Biology, University of California Santa Barbara, Santa Barbara, CA 93106 9610, USA
    Am J Hum Genet 79:194-6. 2006
  51. pmc What would you do if you could sequence everything?
    Avak Kahvejian
    Helicos BioSciences, One Kendall Square, Cambridge, Massachusetts 02139, USA
    Nat Biotechnol 26:1125-33. 2008
    It could be argued that the greatest transformative aspect of the Human Genome Project has been not the sequencing of the genome itself, but the resultant development of new technologies...
  52. ncbi Impact of human genome project on medical practice
    G R Sridhar
    Endocrine and Diabetes Centre, Visakhapatnam
    J Assoc Physicians India 49:995-8. 2001
    ..Nearly 3.1 billion nucleotide bases were sequenced using the clone based approach of Human Genome Project Consortium and the shotgun approach of Celera...
  53. ncbi A new dimension for the human genome project: towards comprehensive expression maps
    T Strachan
    Department of Human Genetics, University of Newcastle upon Tyne, UK
    Nat Genet 16:126-32. 1997
    The current Human Genome Project is largely devoted to structural characterisation of our genome...
  54. ncbi Cancer and genomics
    P A Futreal
    Cancer Genome Project, Sanger Centre, Cambridge, UK
    Nature 409:850-2. 2001
    ..Our experiment underscores the limited amount and variable quality of DNA sequence from cancer cells that is currently available...
  55. ncbi The Human Genome Project, genetics and health
    P Baird
    Department of Medical Genetics, University of British Columbia, 222 6174 University Blvd, Vancouver, BC, V6T 1Z3 Canada
    Community Genet 4:77-80. 2001
    ....
  56. ncbi Future potential of the Human Epigenome Project
    Florian Eckhardt
    Epigenomics AG, Kleine Präsidentenstrasse 1, 10178 Berlin, Germany
    Expert Rev Mol Diagn 4:609-18. 2004
    ..Like single nucleotide polymorphisms, methylation variable positions will greatly advance our ability to elucidate and diagnose the molecular basis of human diseases...
  57. ncbi Sequencing the genome from nematode to human: changing methods, changing science
    Rachel A Ankeny
    Unit for History and Philosophy of Science, Carslaw F07, University of Sydney 2006, NSW, Australia
    Endeavour 27:87-92. 2003
    ..The sequencing of the human genome is no exception. As a crucial part of the Human Genome Project, the history of genomic sequencing is typically presented as a direct result of the discoveries of the ..
  58. ncbi Functional genomics and its implications for molecular medicine
    Ulrich Broeckel
    Department of Medicine, Medical College of Wisconsin, and Department of Pediatrics, Children s Hospital of Wisconsin, 9000 W Wisconsin Avenue, Milwaukee, WI 53226, USA
    Pediatr Clin North Am 53:807-16, vii. 2006
    ..Ultimately how the unique genetic signature of an individual influences the risk and prognosis of disease will be the basis for individualized medicine in the years to come...
  59. doi Profile: meet exhibit I
    Erika Check Hayden
    Nature 451:763-5. 2008
  60. ncbi How the role of computing is driving new genetics' public policy
    Antonio Marturano
    Centre for Leadership Studies, School of Business and Economics, University of Exeter, Streatham Court, Reenes Drive, Exeter EX 4 4PU, UK
    Ethics Inf Technol 6:43-53. 2004
    ..Regarding (2), recent developments in the Human Genome Project (HGP) have shown that computers shape the practices of molecular genetics; an important example is the ..
  61. ncbi Bioethics, the genome, and the Jewish body
    Paul Root Wolpe
    Center of Bioethics, University of Pennsylvania, USA
    Conserv Jud 54:14-25. 2002
  62. ncbi Property rights in genetic information
    Richard A Spinello
    Department of Operations and Strategic Management, Carroll School of Management, Boston College, Chestnut Hill, MA 02467, USA
    Ethics Inf Technol 6:29-42. 2004
    ..This issue has new salience thanks to the Human Genome Project and "bio-prospecting" initiatives based on the aggregation of genetic information, such as the one being ..
  63. ncbi Human genome. Reaching their goal early, sequencing labs celebrate
    Elizabeth Pennisi
    Science 300:409. 2003
  64. ncbi [Genome network project: a national project in post-sequence era]
    Yoshiyuki Sakaki
    Tanpakushitsu Kakusan Koso 49:2986-92. 2004
  65. ncbi [Approach to the research of human functional genomics in China]
    Da long Ma
    Zhonghua Yi Xue Za Zhi 84:1497-8. 2004
  66. ncbi Understanding proteomics
    Janet D Pierce
    School of Nursing, University of Kansas Medical Center, Kansas City, KS 66160 7504, USA
    Nurs Health Sci 9:54-60. 2007
    ..This review includes the recent discoveries regarding proteomics and its importance in the detection and treatment of disease...
  67. ncbi Transcriptome study in China
    Ze Guang Han
    Chinese National Human Genome Center at Shanghai, 250 Bi Bo Road, Zhanjiang High Tech Park, Pudong, Shanghai 201203, China
    C R Biol 326:949-57. 2003
    ..In addition, EST sequencing for model organisms, including rat, zebrafish, Schistosoma japonicum and rice was performed, aiming at identifying genes associated with physiological and/or pathological characteristics...
  68. ncbi Atherosclerosis: the path from genomics to therapeutics
    David T Miller
    Division of Hematology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Coll Cardiol 49:1589-99. 2007
    ..Resources including the Human Genome Project and the International HapMap project, major technological advances in high-throughput genotyping and ..
  69. pmc Human epigenome project--up and running
    Jane Bradbury
    PLoS Biol 1:E82. 2003
  70. doi Meetings that changed the world: Santa Fe 1986: Human genome baby-steps
    Charles Delisi
    Boston University, USA
    Nature 455:876-7. 2008
  71. pmc HapMap tagSNP transferability in multiple populations: general guidelines
    Jinchuan Xing
    Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah, Salt Lake City, UT 84112, USA
    Genomics 92:41-51. 2008
    ..In addition to our findings, we reviewed over 25 recent studies of tagSNP transferability and propose a general guideline for selecting tagSNPs from HapMap populations...
  72. doi Human genetics: Dr Watson's base pairs
    Maynard V Olson
    Nature 452:819-20. 2008
  73. ncbi Genomic databases as global public goods?
    Ruth Chadwick
    ESRC Centre for the Economic and Social Aspects of Genomics CESAGen A Lancaster Cardiff Collaboration, Lancaster University, Furness College, Lancaster, LA1 4YG, UK
    Res Publica 10:123-34. 2004
    ..We shall argue that social and political arrangements are relevant and that recognising this opens the door to construing the use of global public goods language as a strategic one...
  74. ncbi Genome research: the next generation
    F S Collins
    National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Cold Spring Harb Symp Quant Biol 68:49-54. 2003
  75. ncbi The human genome sequence: impact on health care
    M D Bashyam
    Centre for DNA Fingerprinting and Diagnostics, Nacharam, Hyderabad, India
    Indian J Med Res 117:43-65. 2003
    ..This review discusses all these aspects and dwells on the possible impact of the human genome sequence on human health, medicine and also health care delivery system...
  76. ncbi GeneLoc: exon-based integration of human genome maps
    Naomi Rosen
    Weizmann Institute of Science, Rehovot, Israel
    Bioinformatics 19:i222-4. 2003
    ..Despite the numerous available whole-genome mapping resources, no comprehensive, integrated map of the human genome yet exists...
  77. ncbi [The road toward molecular comprehension of diseases]
    Ma Teresa Tusie Luna
    Unidad de Biología Molecular y Medicina Genómica, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Instituto de Investigaciones Biomédicas de la UNAM
    Rev Invest Clin 55:143-7. 2003
  78. ncbi Genomic research and data-mining technology: implications for personal privacy and informed consent
    Herman T Tavani
    Department of Philosophy, Rivier College, Nashua, NH 03060, USA
    Ethics Inf Technol 6:15-28. 2004
    ..social implications (ELSI) program requirements that were established to guide researchers working on the Human Genome Project (HGP)...
  79. ncbi Use of genome browsers to locate your favorite genes
    Minou Bina
    Department of Chemistry, Purdue University, West Lafayette, IN, USA
    Methods Mol Biol 338:1-7. 2006
    ..The example describes mapping, in the human genome, the promoter region of the NF-IL6 gene. The procedure is applicable to creating maps of the desired regions in genomes of other species available at the genome browser at UCSC...
  80. ncbi A haplotype map of the human genome
    Michael Olivier
    Physiol Genomics 13:3-9. 2003
  81. ncbi [Human cDNA and protein expression]
    Sumio Sugano
    Tanpakushitsu Kakusan Koso 47:997-1002. 2002
  82. ncbi Practical genomics. Out of the lab, into practice
    Haydn Bush
    Hosp Health Netw 81:36-41, 2. 2007
    ..Some hospitals are pushing forward on the genomics front despite daunting obstacles, including cost, fear of misuse of data by insurers, and an inability to share data...
  83. ncbi Mexico launches bold genome project
    Veronica Guerrero Mothelet
    Nat Biotechnol 23:1030. 2005
  84. doi A navigator for human genome epidemiology
    Wei Yu
    Nat Genet 40:124-5. 2008
  85. ncbi Genomics. Taking aim at Celera's shotgun
    Jennifer Couzin
    Science 295:1817. 2002
  86. pmc On the sequencing of the human genome
    Robert H Waterston
    Genome Sequencing Center, Washington University, Saint Louis, MO 63108, USA
    Proc Natl Acad Sci U S A 99:3712-6. 2002
    Two recent papers using different approaches reported draft sequences of the human genome. The international Human Genome Project (HGP) used the hierarchical shotgun approach, whereas Celera Genomics adopted the whole-genome shotgun (WGS) ..
  87. doi International genome project launched
    Erika Check Hayden
    Nature 451:378-9. 2008
  88. ncbi The Harvard case of Xu Xiping: exploitation of the people, scientific advance, or genetic theft?
    Margaret Sleeboom
    Amsterdam School of Social Science Research, University of Amsterdam, The Netherlands
    New Genet Soc 24:57-78. 2005
    ....
  89. ncbi Plasmodium, human and Anopheles genomics and malaria
    Stephen L Hoffman
    Celera Genomics, 45 West Gude Drive, Rockville, Maryland 20850, USA
    Nature 415:702-9. 2002
    ....
  90. ncbi [Gene therapy and tissue engineering in nephrology and renal transplantation]
    E Imai
    Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine
    Nippon Rinsho 59:65-71. 2001
    b>Human genome project will be completed in 2003 and we will soon obtain the information of the whole DNA sequence of the human genome...
  91. ncbi [Perspectives on postgenome medicine: Gene therapy for brain tumors]
    M Mizuno
    Department of Molecular Neurosurgery, Nagoya University, Graduate School of Medicine
    Nippon Rinsho 59:76-80. 2001
    ..We have developed a cytokine gene therapy for malignant glioma since about 10 years ago. Here, we introduce both suicide gene therapies and immune gene therapies including our case(IFN-beta gene therapy)...
  92. ncbi [Perspectives on postgenome medicine: Gene therapy for lung cancer]
    K Hagiwara
    Respiratory Medicine and Translational Research Clinic, Tohoku University Hospital
    Nippon Rinsho 59:81-4. 2001
    ..In this article, by reviewing the possible approach, an ideal combination of the future remedies is discussed...
  93. ncbi Owning the stuff of life
    Gary Stix
    Sci Am 294:76-83. 2006
  94. ncbi Genomics. Genome centers push for polished draft
    Elizabeth Pennisi
    Science 296:1600-1. 2002
  95. ncbi The times they are a-changin'
    Ari Patrinos
    Office of Biological and Environmental Research, Office of Science, US Department of Energy, 19901 Germantown Road, Germantown, Maryland 20874 1290, USA
    Nature 417:589-90. 2002
  96. ncbi The Human Genome Project: a player's perspective
    Maynard V Olson
    Department of Medicine, UW Genome Center, University of Washington, Box 352145, Seattle, WA 98195, USA
    J Mol Biol 319:931-42. 2002
  97. ncbi Planning the genome institute's future
    Wendy R Uhlmann
    Science 299:1515; author reply 1515. 2003
  98. ncbi Genomics, genetic epidemiology, and genomic medicine
    Konstantinos N Lazaridis
    Division of Gastroenterology and Hepatology, Center for Basic Research in Digestive Diseases, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Clin Gastroenterol Hepatol 3:320-8. 2005
    ..This opportunity is the result of the recent completion of the Human Genome Project. It is anticipated that genomics will bring to physicians a powerful means to discover hereditary elements ..
  99. ncbi Genes, genomes and identity. Projections on matter
    Christine Hauskeller
    ESRC Centre for Genomics in Society, University of Exeter, Amory Building, Rennes Drive, Exeter EX4 4RJ, UK
    New Genet Soc 23:285-99. 2004
    ..My analysis will show how this trend is a reactionary response to modern understandings of identities as social products and that it ignores new biomedical understandings of human bodies...
  100. ncbi Free genome databases finally defeat Celera
    Emma Marris
    Nature 435:6. 2005

Research Grants80

  1. Genomics of RNA Editing: Identification and Regulation
    Jin Billy Li; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Through the efforts of the Human Genome Project and other large-scale investigations, it has become clear that the molecular origins of human complexity, disease, and distinctness from other organisms ..
  2. FASEB SRC on Hematopoietic Malignancies
    MICHELLE ALICE KELLIHER; Fiscal Year: 2011
    ..learned from the use of animal models;identification of LSCs and anti- LSC therapies;6) The impact of the human genome project in investigations of hematological malignancies, with an emphasis on functional genomics;7) Application of ..
  3. Mammalian Mitochondrial One-Carbon Metabolism
    DEAN RAMSAY APPLING; Fiscal Year: 2010
    ..Using molecular tools made possible by the Human Genome Project, we are now able to study the mitochondrial pathway in humans and other mammals...
  4. Analysis of Redox Modulated Signaling Networks in Response to Ionizing Radiation
    Cristina Furdui; Fiscal Year: 2013
    ..The completion of the human genome project and genetic screenings of several hundreds of human cancers over the last years, have led to the ..
  5. Using Microfluidic Affinity Analysis to Probe Transcriptional Regulation
    POLLY MORRELL FORDYCE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In a watershed achievement, the Human Genome Project (HGP) recently sequenced the entire human genome, providing a wealth of information about potential genes and regulatory sequences...
  6. DNA-Binding Protein Discovery by the Combinatorial Method REPSA
    Michael van Dyke; Fiscal Year: 2013
    ..While the Human Genome Project has yielded a wealth of information for both the human genome and other model organisms, much remains to be ..
  7. Complete genomic DNA sequence of the sooty mangabey MHC
    Daniel E Geraghty; Fiscal Year: 2012
    ..As the human genome project has shown many times over, the establishment of framework genomic DNA sequences can provide fundamental ..
  8. Ion Channel Function in Auditory &Vestibular Hair Cells
    Jeffrey R Holt; Fiscal Year: 2013
    ..We will investigate a handful of genes, of the approximately 26,000 identified through the human genome project, that we suspect are critical for normal hearing and balance...
  9. MECHANISMS OF ENHANCER DEPENDENT SPLICE SITE ACTIVATION
    Klemens J Hertel; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): With the completion of the human genome project, it has become clear that the number of genes cannot account for the complexity of the human proteome...
  10. A Risk Management Framework for Identifiability in Genomics Research
    Bradley A Malin; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): When the Human Genome Project was completed almost ten years ago it cost millions of dollars to sequence an individual's genome...
  11. Aberrant Platelet Mechanisms in Inherited Human Platelet Function Disorders
    ANGARA KONETI RAO; Fiscal Year: 2010
    ..It represents application of the recent advances in genomics and the Human Genome Project to a group of patients who are frequently encountered but extremely poorly characterized...
  12. Generation and validation of a comprehensive human disease mutant ORF resource
    Luke J Whitesell; Fiscal Year: 2010
    ..Modern molecular medicine, propelled by the human genome project, has been exceptionally successful at identifying specific mutations that contribute to disease...
  13. Rapid and inexpensive screening of disease candidate genes in mice
    KATHLEEN JOYCE MILLEN; Fiscal Year: 2010
    ..Although the Human Genome Project has allowed identification of many human disease genes, current technology to model human diseases in mice ..
  14. HUMAN TRANSCRIPTION FACTOR IMMUNOGENS: GENERATION OF A COMPLETE SET
    Gaetano T Montelione; Fiscal Year: 2012
    ..RELEVANCE (See instmctions): The human genome project gave us a complete blueprint for the genetic instructions that control human biology...
  15. Cross-species network approach to predict epistatic cancer susceptibility genes
    Pei Wang; Fiscal Year: 2012
    Project Summary/Abstract Completion of the human genome project has resulted in rapid advances in technology as well as a deluge of genomic data...
  16. Metamoodics: Meta-analyses and bioinformatics display of mood disorders genetics
    Peter P Zandi; Fiscal Year: 2012
    ..Recent advances from the Human Genome Project and in genotyping technology have made it possible to interrogate the genome for disease causing variants ..
  17. Statistical Genomics and Systems Biology Workshop
    JEANETTE CHRISTINE PAPP; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The human genome project and its offshoots have dramatically increased the amount of genetic data available to researchers...
  18. Self-Organization of the Human Genome
    STEVEN TODD KOSAK; Fiscal Year: 2011
    ..Public Health Relevance: With the completion of the human genome project in 2003 and the growing interest in personalized medicine, it is imperative to investigate the dynamic ..
  19. Clinical sequencing in cancer: Clinical ethical and technological studies
    GAIL PAIRITZ JARVIK; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Since the completion of the Human Genome Project in 2001, there have been great expectations for translating human genomic information directly into clinically practice...
  20. Functional evaluation of GWAS loci for cardiovascular intermediate phenotypes
    Calum A Macrae; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: With the completion of the Human Genome Project there has been a wave of genetic studies, generating large numbers of new potential disease genes...
  21. Maternal Smoking: DNA Repair Polymorphisms and the Risk of Septal Heart Defects
    Sadia Malik; Fiscal Year: 2012
    ..The candidate will use new genomic tools provided by the Human Genome Project and the International HapMap Project as well as access to the largest case-control study of birth defects ..
  22. Endogenous glycosphingolipid antigens for NKT cells
    Dapeng Zhou; Fiscal Year: 2013
    ..The completion of human genome project and the advancement of mass spectrometry technology provide the framework to move the field of lipid ..
  23. Identification of artery- and vein-specific cis elements in the human genome
    Nathan D Lawson; Fiscal Year: 2012
    ..Together, these studies will allow us to map the transcriptional regulatory inputs that contribute to arterial and venous endothelial differentiation and blood vessel identity. ..
  24. Novel Mass Spectrometer for Comprhensive No-Loss MS/MS of All Stored Ions
    Sunnie Myung; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The human genome project has inspired significant advancements in high-throughput technologies for the study of function and activation in gene expression...
  25. Vanderbilt Genome Electronic Records Project
    Dan M Roden; Fiscal Year: 2013
    ..important conditions like disease susceptibility or drug responses represent the first fruits of the Human Genome Project. A challenge - that this proposal addresses - is how to analyze and use this torrent of information to ..
  26. New Separations for MALDI-TOF Mass Spectrometry
    Marvin L Vestal; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The human genome project has established the molecular approach to understanding biology, but present knowledge of how an organism ..
  27. Pediatric Endocrine Fellowship Training in Diabetes Research
    CHARLES ALFRED STANLEY; Fiscal Year: 2012
    ..advancing diabetes and endocrine research in children provided by such recent scientific advances as the Human Genome Project, islet transplantation and biomechanical and bio-engineered islets, and the NIH roadmap plans to transform ..
  28. HIGH RESOLUTION ULTRASOUND SYSTEM FOR CARDIOVASCULAR PHENOTYPING IN MICE
    Attila Kovacs; Fiscal Year: 2010
    ..The human genome project holds great promise in developing breakthrough treatments for common illnesses, a promise that can only be ..
  29. New Technologies for Quantitative Phosphorylation Analysis
    Steven P Gygi; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Global genome initiatives including the Human Genome Project have generated enormous amounts of information, spawned new technologies and catalyzed the emergence of a new discipline in biology...
  30. Nociceptive Ion Channels: mechanisms of activation
    Ardem Patapoutian; Fiscal Year: 2010
    ..A great deal remains unknown about the genes involved in sensing these stimuli. With the completion of the human genome project, we have powerful new methods to identify these elusive sensory molecules...
  31. Career Development Program in Pediatric Diabetes Research (K12) at CHOP
    Steven M Willi; Fiscal Year: 2013
    ..for advancing diabetes research in children provided by such pivotal scientific advances as the Human Genome Project, and improved success in islet transplantation and the production of biomechanical and bio-engineered ..
  32. Targeted Inhibition of NMD to Enhance the Efficacy of Readthrough Drugs
    Adrian R Krainer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The successful completion of the human genome project and mapping of many disease genes, combined with advances in the molecular understanding of gene-expression pathways, provides unprecedented ..
  33. Genomic Tools For Studying The Ecology Of The Human Vaginal Microflora
    Jacques Ravel; Fiscal Year: 2010
    ..We view this work as analogous to the human genome project, in which initial sequence information provided a platform for decades of future work focused on all aspect ..
  34. Pathway to Accelerate Clinical Development in Gene Transfer: cGMP Vector Core
    Katherine A High; Fiscal Year: 2010
    ..core project directly supports translational medicine research seeking to realize the full potential of the Human Genome Project. Gene-based therapies have been in clinical trials for nearly two decades, but are only now reaching the ..
  35. MeV: Software for Next Generation Genomic Data Analysis
    John Quackenbush; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Project Summary: The most transformative aspect of the Human Genome Project was not the sequence of the genome itself, but the technologies that the project has spawned...
  36. Mapping the Human Toxome by Systems Toxicology
    Thomas Hartung; Fiscal Year: 2013
    ..e. the Human Toxome) will be a large-scale effort, perhaps on the order of the Human Genome Project. In this project, we propose to comprehensively map pathways of endocrine disruption, representing a first ..
  37. Genetics of Taste: A Flavor for Health -- Community Lab and Education Programs
    BRIDGET CROWLEY COUGHLIN; Fiscal Year: 2010
    ..exhibit components will inform participants about the scientific process, the principles of genetics, the human genome project, and genetic variation...
  38. Gene Targeting Using Modular Zinc Finger Nulceases
    Howard I Sirotkin; Fiscal Year: 2012
    ..RELEVANCE: The human genome project has identified thousands of novel genes, but the activity of many of these genes remains unknown...
  39. Rational Integration of Genomic Healthcare Testing (RIGHT)
    Josh F Peterson; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): A widely-held vision arising from the Human Genome Project is to guide therapeutic decision making with genetic data to improve the safety and efficacy of patient care, a promise that is fueled by ..
  40. A S. cerevisiae high-coverage high-quality protein-protein binary interactome map
    Marc Vidal; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: The human genome project has provided us with a catalogue of all human genes. Each of the ~20...
  41. Statistical Methods in Genetic Epidemiology Research
    Jinbo Chen; Fiscal Year: 2012
    ..While voluminous data are becoming available owing to the Human Genome Project and rapid advancement of high throughput genotyping technology, powerful statistical methods are needed for ..
  42. A Genome-wide RNAi Screening Platform for the Common Lab
    Enrique Saez; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Completion of the Human Genome Project has accentuated the need to establish the function of thousands of genes...
  43. Integrated approaches to deriving predictive networks from public data sources
    John Quackenbush; Fiscal Year: 2010
    ..It was hoped that technologies arising from the Human Genome Project, such as DNA microarrays, would provide data that would allow such network models to be developed...
  44. Epidemiologic Architecture for Genes Linked to Environment (EAGLE)
    Dana C Crawford; Fiscal Year: 2013
    With the advent of the Human Genome Project, the International HapMap Project, and high-throughput yet cost-effective genotyping, it is now possible to interrogate the human genome with >1 million markers for associations with common ..
  45. Molecular Phenotypes of Primary Open Angle Glaucoma
    Mary K Wirtz; Fiscal Year: 2010
    ..involved in complex traits, such as POAG, has been facilitated by the significant progress made by the human genome project. To tease out the potentially important genes from this complex disorder, the general phenotype of POAG ..
  46. A Personalized Genomic Medicine Pilot Program Using the NJgene eMERGE Experience
    Maureen E Smith; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): One promise of the human genome project was to enable genome-informed personalized medicine. During the past four years Northwestern has been a site in the eMERGE network...
  47. Combinational and Computational Methids for the Analysis, Prediction, and Design
    CHRISTINE E HEITSCH; Fiscal Year: 2011
    The Human Genome Project and related efforts have generated enormous amounts of raw biological sequence data...
  48. Regulatory Morif Discovery in the Human Genome Using Comparative Genomics
    Manolis Kellis; Fiscal Year: 2013
    To realize the promise of the human genome project, we need not only the parts list of all the genes, but also a comprehensive understanding of how they function together...
  49. International Assessments of Patenting in Genetics
    Philip Pardey; Fiscal Year: 2010
    ..The National Institutes of Health, through the Human Genome Project among others, specifically recognizes the need for policy options in the area of intellectual property to ..
  50. Clinical Pharmacology Drug Action and Pharmacogenetics
    Esteban Gonzalez Burchard; Fiscal Year: 2013
    ..have observed technological miracles including isolation of human embryonic stem cells, completion of the human genome project, generation of new heart valves from stem cells and the discovery of novel genetic risk factors through ..
  51. A Knowledge Base for Clinically Relevant Genes and Variants
    MICHAEL SHAW WATSON; Fiscal Year: 2013
    ..provided by applicant): Fundamental advances in genetic sequencing technologies were stimulated by the human genome project and are now in turn transforming genome science and medicine...
  52. Integrating Microarray and Proteomic Data by Ontology-based Annotation
    Atul J Butte; Fiscal Year: 2011
    With the completion of the Human Genome Project, there is a need to translate genome-era discoveries into clinical utility...
  53. BLACK NEWSPAPER COVERAGE OF GENETICS AND ITS IMPLICATIONS FOR AFRICAN AMERICANS
    CHARLENE ANNE CABURNAY; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The Human Genome Project and the International HapMap Project have produced significant resources for understanding the genetic bases for health and disease, including identifying genetic variations, ..
  54. Regenbase: A Searchable Database to Organize Regeneration Knowledge via Ontologie
    STEPHAN C SCHURER; Fiscal Year: 2013
    ..allow the integration and interrogation of the massive and diverse data sets that have been produced by the human genome project. In the area of neuroscience the most advancement have been made in the creation and annotation of large ..
  55. Predicting Protein-DNA Interactions with Structural Models
    Philip Bradley; Fiscal Year: 2013
    ..protein-DNA structures and interactions using only protein sequence data (such as that generated by the human genome project)...
  56. Evaluating the Cost Effectiveness of Alternative Sample Designs for Genetic Assoc
    Nathan L Tintle; Fiscal Year: 2011
    ..to human disease via genetic association studies has grown significantly since the completion of both the Human Genome Project and the International HapMap Project...
  57. Nanoscale approaches to allelic silencing in myocardial disease states
    Euan Ashley; Fiscal Year: 2009
    ..revolutionize the treatment of diverse genetic diseases and finally fulfill the therapeutic promise of the human genome project. Finally, I argue that the most innovative ideas would never have been noticed without timing: with the ..
  58. Knowledge Synthesis Center for Genomic Applications
    Evelyn P Whitlock; Fiscal Year: 2012
    DESCRIPTION: The rapid development of genomic applications in the wake of the Human Genome Project creates both opportunities and challenges...
  59. 7th International Conference on Frontotemporal Dementias
    BERNARDINO FRANCESCO GHETTI; Fiscal Year: 2010
    ..During the same period of time, the rapid developments in molecular genetics and the completion of the human genome project have allowed FTD research to progress much more rapidly than in the preceding 100 years...
  60. Comprehensive Database System for Modern MALDI- TOF and TOF-TOF MS and MS-MS
    Marvin L Vestal; Fiscal Year: 2010
    ..related projects will provide the tools required for significant progress in the proteomics analog to the human genome project. The major remaining challenge involves converting the massive volume of data than can be produced by these ..
  61. Targeted Research and Academic Training of Nurses in Genomics
    Yvette Conley; Fiscal Year: 2013
    ..research continues to benefit greatly from improved technologies and large research efforts such as the Human Genome Project, International HapMap project, the 1000 Genomes Project, and the Cancer Genome Atlas project...
  62. Copy number variation in the human genome
    Charles Lee; Fiscal Year: 2010
    ..Data from the Human Genome Project originally suggested that any two humans are 99.9% identical in their DNA sequences...
  63. HUMAN GENOME EDUCATION MODEL (HUGEM) PROJECT II
    E Lapham; Fiscal Year: 2001
    ..abstract) The field of medical genetics continues to witness dramatic advances (largely resulting from the Human Genome Project) which have led to an increased demand for genetic services and brought genetics issues to the forefront of ..
  64. CODING & NONCODING REGIONS IN DNA SEQUENCES
    THOMAS JUKES; Fiscal Year: 1991
    ..The information that eventually will emerge from the human genome project will be sequences of about 3 billion of these variables...
  65. The repetitive DNA structure of the human genome
    PETER WARBURTON; Fiscal Year: 2009
    The repetitive DNA structure of the human genome The recent completion of the human genome project gives today's scientists the privileged opportunity to provide, for the first and only time, a detailed comprehensive description of ..
  66. EFFECTS OF GENE PATENTS ON GENETIC TESTING AND RESEARCH
    Mildred Cho; Fiscal Year: 2002
    Genes and other sequences discovered through the Human Genome Project and large-scale sequencing efforts by private biotechnology companies are being rapidly patented by non-profit academic and for-profit institutions...
  67. TRYPANOSOMA CRUZI GENOME PROJECT AT TIGR
    Najib El Sayed; Fiscal Year: 2004
    ..Recently, progress on the human genome project, and the determination of the yeast genomic sequence, have unambiguously demonstrated the value of using ..
  68. INTEGRATED DNA SEQUENCING SYSTEM
    Stevan Jovanovich; Fiscal Year: 2001
    DESCRIPTION: (Applicant's Abstract) The Human Genome Project is rapidly developing a draft consensus sequence of the Human Genome...
  69. NEUROBIOLOGY AND GENETICS OF AUTISM
    M Spence; Fiscal Year: 2004
    ..and ACTH respond and interact differently before and after challenge in some children with AD and (3) the Human Genome Project has provided ahead of schedule a dense map of the human genome including about half of the expressed genes (..
  70. STATE GOVERNMENTS AND THE HUMAN GENOME PROJECT
    R Brown; Fiscal Year: 1991
    The 1988 Congressional funding for the Human Genome Project promises to deliver knowledge with great promise to solve many human problems...
  71. The ELSI Program: Evidence of Policy Impact
    DEBRA JH MATHEWS; Fiscal Year: 2010
    ..of Health and Department of Energy were established to address ethical and related issues raised by the Human Genome Project. A stated goal of the ELSI program has been to influence policy related to the ethical, legal and social ..
  72. ADDRESSING THE ISSUE OF GAP REGIONS IN GENOME SEQUENCING
    John SantaLucia; Fiscal Year: 2001
    DESCRIPTION: (Adapted from the investigator's abstract) The Human Genome Project (HGP) promises to deliver a complete human genome sequence by the year 2005...
  73. ETHICAL AND LEGAL IMPLICATIONS OF GENETIC TESTING
    ALBERT TEICH; Fiscal Year: 1991
    Advances in genetic testing emerging from the Human Genome Project will have applications in many sectors, including: 1) medical research and practice, 2) the workplace, 3) insurance, and 4) law enforcement and the courtroom...
  74. Molecular Approach in Predicting 5-Fluorouracil Efficacy
    Robert Diasio; Fiscal Year: 2005
    The advancement of the Human Genome Project along with the development of new techniques such as gene chips, automated gene-sequencers and real time quantitative PCR (RT -QPCR) have resulted in a rapidly expanding discipline devoted to ..
  75. High Throughput Genome Sequencer for Organ Building
    Richard Maas; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The Human Genome Project affords an unrivaled opportunity to advance our understanding of the genetic basis of organismal biology...
  76. MAPPING AND SEQUENCING THE HUMAN GENOME
    Richard Myers; Fiscal Year: 1999
    The long term objective of this GESTEC proposal is to achieve three of the primary goals of the Human Genome Project over the next five years: 1. Construct a physical map of the entire human genome at 100 kb average resolution. 2...
  77. MULTIPLEXED DNA SEQUENCING USING CGE & NIR FLUORESCENCE
    Steven Soper; Fiscal Year: 1999
    The Human Genome Project is a high priority area for the NIH, since the long-range goals of this project will have important ramifications in ameliorating genetic diseases, improving health care and possibly altering the genetic makeup of ..
  78. Genetic Discrimination Knowledge in Primary Care
    Jeffrey Weitzel; Fiscal Year: 2004
    Rapid advances in molecular genetics and publication of the first draft of the Human Genome Project have ushered in a new era in medicine, where genetic information can be used to identify individuals predisposed to disease...
  79. CANCER AND THE HUMAN GENOME: ETHICAL IMPLICATIONS
    Robert Proctor; Fiscal Year: 1992
    The specter of eugenics is commonly raised in concerns about the ethical and legal implications of the Human Genome Project. The present project explores the relevance of eugenics to genomics, using historical methods...
  80. Learning About Research in North Carolina (LeARN)
    Giselle Corbie Smith; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): As the Human Genome Project develops beyond the mapping and sequencing of the human genome to a tool for understanding genetic variation, gene-environment interaction and disease expression, the need ..