amino acid motifs

Summary

Summary: Commonly observed structural components of proteins formed by simple combinations of adjacent secondary structures. A commonly observed structure may be composed of a CONSERVED SEQUENCE which can be represented by a CONSENSUS SEQUENCE.

Top Publications

  1. ncbi Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding
    J E Garrus
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Cell 107:55-65. 2001
  2. ncbi T-Coffee: A novel method for fast and accurate multiple sequence alignment
    C Notredame
    National Institute for Medical Research, The Ridgeway, London, NW7 1AA, UK
    J Mol Biol 302:205-17. 2000
  3. ncbi Genome-wide mapping of in vivo protein-DNA interactions
    David S Johnson
    Department of Genetics, Stanford University School of Medicine, Stanford, CA, 94305 5120, USA
    Science 316:1497-502. 2007
  4. ncbi Locating proteins in the cell using TargetP, SignalP and related tools
    Olof Emanuelsson
    Stockholm Bioinformatics Center, AlbaNova, Stockholm University, SE 10691 Stockholm, Sweden
    Nat Protoc 2:953-71. 2007
  5. doi Attributes of short linear motifs
    Norman E Davey
    Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
    Mol Biosyst 8:268-81. 2012
  6. pmc ELM: the status of the 2010 eukaryotic linear motif resource
    Cathryn M Gould
    Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nucleic Acids Res 38:D167-80. 2010
  7. pmc Comparative genomics of the neglected human malaria parasite Plasmodium vivax
    Jane M Carlton
    The Institute for Genomic Research J Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
    Nature 455:757-63. 2008
  8. pmc Structure of a beta1-adrenergic G-protein-coupled receptor
    Tony Warne
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nature 454:486-91. 2008
  9. pmc MEME: discovering and analyzing DNA and protein sequence motifs
    Timothy L Bailey
    Institute of Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia
    Nucleic Acids Res 34:W369-73. 2006
  10. pmc SLiMSearch 2.0: biological context for short linear motifs in proteins
    Norman E Davey
    Structural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Nucleic Acids Res 39:W56-60. 2011

Research Grants

  1. Designing Spider Silk Proteins as Novel Biomaterials
    Randolph Lewis; Fiscal Year: 2005
  2. Potentiation of Glycine Receptors by Ethanol
    LUIS GERARDO AGUAYO; Fiscal Year: 2010
  3. Potentiation of Glycine Receptors by Ethanol
    LUIS GERARDO AGUAYO; Fiscal Year: 2010
  4. Designing Spider Silk Proteins as Novel Biomaterials
    Randolph Lewis; Fiscal Year: 2007
  5. Designing Spider Silk Proteins as Novel Biomaterials
    Randolph Lewis; Fiscal Year: 2009
  6. THE ROLE OF EPSILON SUBUNIT IN GABAA RECEPTOR FUNCTION
    TIM HALES; Fiscal Year: 2003
  7. SIGNALING MECHANISMS OF SOMATOSTATIN RECEPTORS
    DIANE BARBER; Fiscal Year: 2002
  8. MOLECULAR CHARACTERIZATION OF ACYL-COA DEHYDROGENASES
    Gerard Vockley; Fiscal Year: 1993
  9. ENDONUCLEASES OF INTERRUPTED PROKARYOTIC GENES
    Marlene Belfort; Fiscal Year: 2002
  10. Glucuronidation of Fatty Acids by Human ER & Nuclear UGT
    Anna Radominska Pandya; Fiscal Year: 2002

Detail Information

Publications238 found, 100 shown here

  1. ncbi Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding
    J E Garrus
    Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Cell 107:55-65. 2001
    ..These observations suggest that retroviruses bud by appropriating cellular machinery normally used in the Vps pathway to form multivesicular bodies...
  2. ncbi T-Coffee: A novel method for fast and accurate multiple sequence alignment
    C Notredame
    National Institute for Medical Research, The Ridgeway, London, NW7 1AA, UK
    J Mol Biol 302:205-17. 2000
    ..The improvement, especially clear with the more difficult test cases, is always visible, regardless of the phylogenetic spread of the sequences in the tests...
  3. ncbi Genome-wide mapping of in vivo protein-DNA interactions
    David S Johnson
    Department of Genetics, Stanford University School of Medicine, Stanford, CA, 94305 5120, USA
    Science 316:1497-502. 2007
    ..96] and statistical confidence (P <10(-4)), properties that were important for inferring new candidate interactions. These include key transcription factors in the gene network that regulates pancreatic islet cell development...
  4. ncbi Locating proteins in the cell using TargetP, SignalP and related tools
    Olof Emanuelsson
    Stockholm Bioinformatics Center, AlbaNova, Stockholm University, SE 10691 Stockholm, Sweden
    Nat Protoc 2:953-71. 2007
    ..In addition, we describe and provide web references to other useful subcellular localization predictors. Finally, we discuss predictive performance measures in general and the performance of TargetP and SignalP in particular...
  5. doi Attributes of short linear motifs
    Norman E Davey
    Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
    Mol Biosyst 8:268-81. 2012
    ..Finally, the most interesting conclusions are examined in regard to their functional consequences...
  6. pmc ELM: the status of the 2010 eukaryotic linear motif resource
    Cathryn M Gould
    Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany
    Nucleic Acids Res 38:D167-80. 2010
    ..Using the links, researchers can explore the motifs, proteins, complex structures and associated literature to evaluate whether candidate motifs might be worth experimental investigation...
  7. pmc Comparative genomics of the neglected human malaria parasite Plasmodium vivax
    Jane M Carlton
    The Institute for Genomic Research J Craig Venter Institute, 9704 Medical Research Drive, Rockville, Maryland 20850, USA
    Nature 455:757-63. 2008
    ..Completion of the P. vivax genome provides the scientific community with a valuable resource that can be used to advance investigation into this neglected species...
  8. pmc Structure of a beta1-adrenergic G-protein-coupled receptor
    Tony Warne
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nature 454:486-91. 2008
    ....
  9. pmc MEME: discovering and analyzing DNA and protein sequence motifs
    Timothy L Bailey
    Institute of Molecular Bioscience, The University of Queensland, St Lucia, QLD 4072, Australia
    Nucleic Acids Res 34:W369-73. 2006
    ..This article describes the freely accessible web server and its architecture, and discusses ways to use MEME effectively to find new sequence patterns in biological sequences and analyze their significance...
  10. pmc SLiMSearch 2.0: biological context for short linear motifs in proteins
    Norman E Davey
    Structural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Nucleic Acids Res 39:W56-60. 2011
    ..Users can search motifs against the human proteome or a subset thereof defined by Uniprot accession numbers or GO term. The SLiMSearch server is available at: http://bioware.ucd.ie/slimsearch2.html...
  11. ncbi Signals for sorting of transmembrane proteins to endosomes and lysosomes
    Juan S Bonifacino
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Biochem 72:395-447. 2003
    ..This complex array of signals and recognition proteins ensures the dynamic but accurate distribution of transmembrane proteins to different compartments of the endosomal-lysosomal system...
  12. ncbi The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains
    B K Kay
    Department of Pharmacology, University of Wisconsin Madison, Madison, Wisconsin 53706 1532, USA
    FASEB J 14:231-41. 2000
    ..Kay, B. K., Williamson, M. P., Sudol, M. The importance of being proline: the interaction of proline-rich motifs in signaling proteins with their cognate domains...
  13. pmc Diversity and complexity in DNA recognition by transcription factors
    Gwenael Badis
    Banting and Best Department of Medical Research, University of Toronto, Toronto, ON M5S 3E1, Canada
    Science 324:1720-3. 2009
    ..This complexity in DNA recognition may be important in gene regulation and in the evolution of transcriptional regulatory networks...
  14. ncbi Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment
    Stephen B Long
    Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
    Nature 450:376-82. 2007
    ..The detailed structure, which can be compared directly to a large body of functional data, explains charge stabilization within the membrane and suggests a mechanism for voltage-sensor movements and pore gating...
  15. ncbi Feature-based prediction of non-classical and leaderless protein secretion
    Jannick Dyrløv Bendtsen
    Center for Biological Sequence Analysis BioCentrum DTU, Building 208, Technical University of Denmark, DK 2800 Lyngby, Denmark
    Protein Eng Des Sel 17:349-56. 2004
    ..By scanning the entire human proteome we identified new proteins potentially undergoing non-classical secretion. Predictions can be made at http://www.cbs.dtu.dk/services/SecretomeP...
  16. pmc Integrin ligands at a glance
    Jonathan D Humphries
    Wellcome Trust Centre for Cell Matrix Research, Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK
    J Cell Sci 119:3901-3. 2006
  17. doi An EB1-binding motif acts as a microtubule tip localization signal
    Srinivas Honnappa
    Biomolecular Research, Structural Biology, Paul Scherrer Institut, 5232 Villigen PSI, Switzerland
    Cell 138:366-76. 2009
    ..Our findings establish a general "microtubule tip localization signal" (MtLS) and delineate a unifying mechanism for this subcellular protein targeting process...
  18. pmc STAMP: a web tool for exploring DNA-binding motif similarities
    Shaun Mahony
    Department of Computational Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Nucleic Acids Res 35:W253-8. 2007
    ..STAMP also directly accepts the output files from 12 supported motif-finders, enabling quick interpretation of motif-discovery analyses. STAMP is available at http://www.benoslab.pitt.edu/stamp...
  19. ncbi Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors
    Ding Yen Lin
    Institute of Biomedical Sciences, Academia Sinica, Taipei 11529, Taiwan, Republic of China
    Mol Cell 24:341-54. 2006
    ..Our results provide mechanistic insights into Daxx in SUMO-dependent transcriptional control and subnuclear compartmentalization...
  20. pmc A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation
    Xin Zeng
    Neurobiology Program, Children s Hospital Boston, Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 438:873-7. 2005
    ....
  21. pmc Genome-wide analysis of Arabidopsis pentatricopeptide repeat proteins reveals their essential role in organelle biogenesis
    Claire Lurin
    Unite de Recherche en Genomique Vegetale, Institut National de la Recherche Agronomique Centre National de la Recherche Scientifique Université d Evry Val d Essone, CP 5708, 91057 Evry Cedex, France
    Plant Cell 16:2089-103. 2004
    ..These results confirm, but massively extend, the very sparse observations previously obtained from detailed characterization of individual mutants in other organisms...
  22. ncbi Prediction of peroxisomal targeting signal 1 containing proteins from amino acid sequence
    Georg Neuberger
    Research Institute of Molecular Pathology, Dr Bohrgasse 7, A 1030 Vienna, Austria
    J Mol Biol 328:581-92. 2003
    ..The predicted presence of a PTS1 signal implies peroxisomal localisation in the absence of N-terminal targeting sequences such as the mitochondrial import signal...
  23. ncbi Cloning of the Arabidopsis clock gene TOC1, an autoregulatory response regulator homolog
    C Strayer
    Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037, USA
    Science 289:768-71. 2000
    ..TOC1 is itself circadianly regulated and participates in a feedback loop to control its own expression...
  24. ncbi HIV-1 and Ebola virus encode small peptide motifs that recruit Tsg101 to sites of particle assembly to facilitate egress
    J Martin-Serrano
    Aaron Diamond AIDS Research Center and The Rockefeller University, New York, New York, USA
    Nat Med 7:1313-9. 2001
    ..Because the Tsg101 is recruited by small, conserved viral sequence motifs, agents that mimic these structures are potential inhibitors of the replication of these lethal human pathogens...
  25. ncbi SYFPEITHI: database for MHC ligands and peptide motifs
    H Rammensee
    Universitat Tubingen, Interfakultäres Institut für Zellbiologie, Abteilung Immunologie, Auf der Morgenstelle 15, D 72076 Tubingen, Germany
    Immunogenetics 50:213-9. 1999
    ..Hyperlinks to the EMBL and PubMed databases are included. In addition, ligand predictions are available for a number of MHC allelic products. The database content is restricted to published data only...
  26. pmc A quantitative atlas of mitotic phosphorylation
    Noah Dephoure
    Department of Cell Biology, Harvard University Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:10762-7. 2008
    ..Analysis of non-proline site-containing phosphopeptides identified two unique motifs that suggest there are at least two undiscovered mitotic kinases...
  27. ncbi Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes
    J L Riechmann
    Mendel Biotechnology, 21375 Cabot Boulevard, Hayward, CA 94545, USA
    Science 290:2105-10. 2000
    ..The genome-wide comparison reveals the evolutionary generation of diversity in the regulation of transcription...
  28. ncbi Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase
    Geng Wu
    Cellular Biochemistry and Biophysics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Mol Cell 11:1445-56. 2003
    ....
  29. ncbi Defining the specificity space of the human SRC homology 2 domain
    Haiming Huang
    Department of Biochemistry, Siebens Drake Medical Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario N6A 5C1, Canada
    Mol Cell Proteomics 7:768-84. 2008
    ..The definition of the specificity space of the human SH2 domain provides both the necessary molecular basis and a platform for future exploration of the functions for SH2-containing proteins in cells...
  30. ncbi Auto-regulation of the circadian slave oscillator component AtGRP7 and regulation of its targets is impaired by a single RNA recognition motif point mutation
    Jan C Schöning
    Department of Molecular Cell Physiology, University of Bielefeld, D 33615 Bielefeld, Germany
    Plant J 52:1119-30. 2007
    ....
  31. doi Crystal structure of opsin in its G-protein-interacting conformation
    Patrick Scheerer
    Institut für Medizinische Physik und Biophysik CC2, Charite Universitatsmedizin Berlin, Chariteplatz 1, D 10117 Berlin, Germany
    Nature 455:497-502. 2008
    ..On the basis of the Ops*-GalphaCT structure and known conformational changes in Galpha, we discuss signal transfer from the receptor to the G protein nucleotide-binding site...
  32. ncbi Specification of SUMO1- and SUMO2-interacting motifs
    Christina Maria Hecker
    Institute for Biochemistry II, Goethe University Medical School, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    J Biol Chem 281:16117-27. 2006
    ....
  33. ncbi PML protein isoforms and the RBCC/TRIM motif
    K Jensen
    Centre for Structural Biology, Imperial College of Science, Technology and Medicine, Flowers Building, Armstrong Road, London SW7 2AZ, UK
    Oncogene 20:7223-33. 2001
    ..In APL oligomerization mediated by the RBCC/TRIM motif is essential for the transformation potential of the PML-RARalpha fusion protein...
  34. doi Close encounters of the third kind: disordered domains and the interactions of proteins
    Peter Tompa
    Institute of Enzymology, Biological Research Center, Hungarian Academy of Sciences, Budapest, Hungary
    Bioessays 31:328-35. 2009
    ..With these points, we argue that these long disordered regions should be recognized as a distinct class of biologically functional protein domains...
  35. pmc On the detection and refinement of transcription factor binding sites using ChIP-Seq data
    Ming Hu
    Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nucleic Acids Res 38:2154-67. 2010
    ..These findings may offer new biological insights into the mechanisms of transcription factor regulation...
  36. pmc Discovering sequence motifs with arbitrary insertions and deletions
    Martin C Frith
    Computational Biology Research Center, National Institute of Advanced Industrial Science and Technology AIST, Tokyo, Japan
    PLoS Comput Biol 4:e1000071. 2008
    ..It may be equally useful for arbitrarily gapped motifs in DNA and RNA, although fewer examples of such motifs are known at present. GLAM2 is public domain software, available for download at http://bioinformatics.org.au/glam2...
  37. ncbi Determination of protease cleavage site motifs using mixture-based oriented peptide libraries
    B E Turk
    Department of Medicine, Beth Israel Deaconess Medical Center, Department of Cell Biology, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Nat Biotechnol 19:661-7. 2001
    ..Our results indicate that a small set of libraries can be used to quickly profile an expanding protease family, providing information applicable to the design of inhibitors and to the identification of protein substrates...
  38. ncbi Adaptors for clathrin coats: structure and function
    David J Owen
    Cambridge Institute for Medical Research, Department of Clinical Biochemistry, University of Cambridge, Cambridge CB2 2XY, UK
    Annu Rev Cell Dev Biol 20:153-91. 2004
    ..This review focuses on the structure of clathrin adaptors and how these structures provide functional information on the mechanism of CCV formation...
  39. doi Structure-function analysis of the NB-ARC domain of plant disease resistance proteins
    Gerben van Ooijen
    Plant Pathology, Swammerdam Institute for Life Sciences, University of Amsterdam, PO Box 94062, 1090 GB Amsterdam, The Netherlands
    J Exp Bot 59:1383-97. 2008
    ..The presented 3D model provides a framework for the formulation of hypotheses on how mutations in the NB-ARC exert their effects...
  40. pmc Secretion modification region-derived peptide disrupts HIV-1 Nef's interaction with mortalin and blocks virus and Nef exosome release
    Martin N Shelton
    Department of Microbiology, Biochemistry, and Immunology, Morehouse School of Medicine, Atlanta, Georgia, USA
    J Virol 86:406-19. 2012
    ..Taken together, this work constitutes a significant step in understanding the underlying mechanism of exNef secretion, identifies a novel host-pathogen interaction, and introduces an HIV-derived peptide with antiviral properties...
  41. doi Prediction of short linear protein binding regions
    Catherine Mooney
    Complex and Adaptive Systems Laboratory, University College Dublin, Dublin, Ireland
    J Mol Biol 415:193-204. 2012
    ..We conclude that, despite the diversity of motif sequences and structures, SLiMPred is a valuable tool for prioritizing potential interaction motifs in proteins...
  42. ncbi Computational identification and analysis of protein short linear motifs
    Norman E Davey
    UCD Complex and Adaptive Systems Laboratory, University College Dublin, Dublin, Ireland
    Front Biosci (Landmark Ed) 15:801-25. 2010
    ..g. of physical protein interactions) as input for computational discovery...
  43. ncbi Parallels between cytokinesis and retroviral budding: a role for the ESCRT machinery
    Jez G Carlton
    Department of Infectious Diseases, King s College London School of Medicine, London, UK
    Science 316:1908-12. 2007
    ..Thus, HIV-1 budding and cytokinesis use a similar subset of cellular components to carry out topologically similar membrane fission events...
  44. doi Cracking the RNA polymerase II CTD code
    Sylvain Egloff
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
    Trends Genet 24:280-8. 2008
    ..How and when is the code written and read? How does it contribute to transcription and coordinate RNA processing?..
  45. pmc Extensive phosphorylation with overlapping specificity by Mycobacterium tuberculosis serine/threonine protein kinases
    Sladjana Prisic
    Division of Infectious Diseases, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:7521-6. 2010
    ..tuberculosis and create a resource for understanding how specific phosphorylation events modulate protein activity. The results further provide the potential to predict likely cognate STPKs for newly identified phosphoproteins...
  46. ncbi Histone demethylation by a family of JmjC domain-containing proteins
    Yu Ichi Tsukada
    Howard Hughes Medical Institute, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
    Nature 439:811-6. 2006
    ..Thus, we identify the JmjC domain as a novel demethylase signature motif and uncover a protein demethylation mechanism that is conserved from yeast to human...
  47. pmc Identification of a SUMO-binding motif that recognizes SUMO-modified proteins
    Jing Song
    Division of Immunology, Beckman Research Institute of the City of Hope, 1450 East Duarte Road, Duarte, CA 91010, USA
    Proc Natl Acad Sci U S A 101:14373-8. 2004
    ..The SUMO-binding motif exists in nearly all proteins known to be involved in SUMO-dependent processes, suggesting its general role in sumoylation-dependent cellular functions...
  48. doi Systematic sequence analysis and identification of tissue-specific or stress-responsive genes of NAC transcription factor family in rice
    Yujie Fang
    National Center of Plant Gene Research, Huazhong Agricultural University, 430070, Wuhan, China
    Mol Genet Genomics 280:547-63. 2008
    ..Considering the fact that a very limited number of genes of the NAC family have been characterized, our data provide a very useful reference for functional analysis of this family in rice...
  49. pmc GlobPlot: Exploring protein sequences for globularity and disorder
    Rune Linding
    European Molecular Biology Laboratory, Biocomputing Unit, D 69117 Heidelberg, Germany
    Nucleic Acids Res 31:3701-8. 2003
    ..GlobPlot has a pipeline interface--GlobPipe--for the advanced user to do whole proteome analysis. GlobPlot can also be used as a generic infrastructure package for graphical displaying of any possible propensity...
  50. pmc Specific protein domains mediate cooperative assembly of HuR oligomers on AU-rich mRNA-destabilizing sequences
    Elizabeth J Fialcowitz-White
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 282:20948-59. 2007
    ..Together, the results define distinct roles for the HuR hinge and RRM3 domains in formation of cooperative HuR.ARE complexes in solution...
  51. pmc Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection
    Eugene Valkov
    School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD 4072, Australia
    Proc Natl Acad Sci U S A 108:14879-84. 2011
    ..Jointly, our results provide a molecular and structural basis for the role of MAL in TLR signaling and disease protection...
  52. pmc Crystal structure of the extracellular segment of integrin alpha Vbeta3
    J P Xiong
    Renal Unit, Leukocyte Biology and Inflammation Program, Structural Biology Program, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Science 294:339-45. 2001
    ..MIDAS lies adjacent to a calcium-binding site with a potential regulatory function...
  53. pmc A PPxY motif within the VP40 protein of Ebola virus interacts physically and functionally with a ubiquitin ligase: implications for filovirus budding
    R N Harty
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 3800 Spruce Street, Philadelphia, PA 19104 6049, USA
    Proc Natl Acad Sci U S A 97:13871-6. 2000
    ..Last, these studies imply that VP40 likely plays an important role in filovirus budding, and that budding of retroviruses, rhabdoviruses, and filoviruses may proceed via analogous mechanisms...
  54. ncbi FANMOD: a tool for fast network motif detection
    Sebastian Wernicke
    Institut fur Informatik, Friedrich Schiller Universität Jena Ernst Abbe Platz 2, 07743 Jena, Germany
    Bioinformatics 22:1152-3. 2006
    ..Additional benefits of FANMOD are the ability to analyze colored networks, a graphical user interface and the ability to export results to a variety of machine- and human-readable file formats including comma-separated values and HTML...
  55. pmc SUMO pathway dependent recruitment of cellular repressors to herpes simplex virus type 1 genomes
    Delphine Cuchet-Lourenço
    MRC University of Glasgow Centre for Virus Research, Glasgow, Scotland, United Kingdom
    PLoS Pathog 7:e1002123. 2011
    ..We conclude that recruitment of ND10 components to sites associated with HSV-1 genomes reflects a cellular defence against invading pathogen DNA that is regulated through the SUMO modification pathway...
  56. doi Motif switches: decision-making in cell regulation
    Kim Van Roey
    Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, D 69117 Heidelberg, Germany
    Curr Opin Struct Biol 22:378-85. 2012
    ....
  57. ncbi Somatic diversification of variable lymphocyte receptors in the agnathan sea lamprey
    Zeev Pancer
    Division of Developmental and Clinical Immunology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nature 430:174-80. 2004
    ..Different evolutionary strategies were thus used to generate highly diverse lymphocyte receptors through rearrangement of LRR modules in agnathans (jawless fish) and of immunoglobulin gene segments in gnathostomes (jawed vertebrates)...
  58. pmc SLiMFinder: a web server to find novel, significantly over-represented, short protein motifs
    Norman E Davey
    Structural and Computational Biology Unit, European Molecular Biology Laboratory, 69117 Heidelberg, Germany
    Nucleic Acids Res 38:W534-9. 2010
    ..Returned motifs can also be compared with known SLiMs from the literature using CompariMotif. All results are available for download. The SLiMFinder server is available at: http://bioware.ucd.ie/slimfinder.html...
  59. pmc Minimotif Miner 3.0: database expansion and significantly improved reduction of false-positive predictions from consensus sequences
    Tian Mi
    Department of Computer Science and Engineering, University of Connecticut, Storrs, CT 06269 2155, USA
    Nucleic Acids Res 40:D252-60. 2012
    ..This online database can be used to predict new functions in proteins and causes of disease...
  60. ncbi Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
    E Oda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Science 288:1053-8. 2000
    ..We also demonstrate that blocking the endogenous Noxa induction results in the suppression of apoptosis. Noxa may thus represent a mediator of p53-dependent apoptosis...
  61. pmc c-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strains
    Doreen Mueller
    University of Magdeburg, Department of Medical Microbiology, Magdeburg, Germany
    J Clin Invest 122:1553-66. 2012
    ..These results provide insight for clinical H. pylori typing and clarify the role of phosphorylated bacterial effector proteins in pathogenesis...
  62. pmc Partitioning of minimotifs based on function with improved prediction accuracy
    Sanguthevar Rajasekaran
    Department of Computer Science and Engineering, University of Connecticut, Storrs, Connecticut, United States of America
    PLoS ONE 5:e12276. 2010
    ..As a step toward resolving this problem we have built, implemented, and tested a new data-driven algorithm that reduces false-positive predictions...
  63. pmc SUMO-targeted ubiquitin ligases in genome stability
    John Prudden
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    EMBO J 26:4089-101. 2007
    ..The DNA repair factor Rad60 and its human homolog NIP45, which contain SLDs, are candidate STUbL targets. Consistently, Rad60 and Slx8-Rfp mutants have similar DNA repair defects...
  64. pmc Mining protein loops using a structural alphabet and statistical exceptionality
    Leslie Regad
    MTI, INSERM UMR S 973, Universite Paris Diderot Paris 7, Paris, F 75205 Cedex 13, France
    BMC Bioinformatics 11:75. 2010
    ..Due to data sparsity, long loops have rarely been systematically studied...
  65. ncbi A conformational analysis of Walker motif A [GXXXXGKT (S)] in nucleotide-binding and other proteins
    C Ramakrishnan
    Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India
    Protein Eng 15:783-98. 2002
    ....
  66. pmc The value of position-specific priors in motif discovery using MEME
    Timothy L Bailey
    Institute for Molecular Bioscience, The University of Queensland, Brisbane 4072, Queensland, Australia
    BMC Bioinformatics 11:179. 2010
    ....
  67. ncbi Water permeation across biological membranes: mechanism and dynamics of aquaporin-1 and GlpF
    B L de Groot
    Theoretical Molecular Biophysics Group, Max Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077 Gottingen, Germany
    Science 294:2353-7. 2001
    ..In AQP1, a fine-tuned water dipole rotation during passage is essential for water selectivity. In GlpF, a glycerol-mediated "induced fit" gating motion is proposed to generate selectivity for glycerol over water...
  68. pmc The c3-v4 region is a major target of autologous neutralizing antibodies in human immunodeficiency virus type 1 subtype C infection
    Penny L Moore
    National Institute for Communicable Diseases, Private Bag X4, Sandringham 2131, Johannesburg, South Africa
    J Virol 82:1860-9. 2008
    ..These data suggest that the C3 and V4 regions combine to form important structural motifs and that epitopes in this region are major targets of the early autologous neutralizing response in HIV-1 subtype C infection...
  69. pmc Scansite 2.0: Proteome-wide prediction of cell signaling interactions using short sequence motifs
    John C Obenauer
    Center for Cancer Research, E18 580, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Nucleic Acids Res 31:3635-41. 2003
    ..In addition, a new series of Sequence Match programs for non-quantitative user-defined motifs has been implemented. Scansite is available via the World Wide Web at http://scansite.mit.edu...
  70. ncbi A general amphipathic alpha-helical motif for sensing membrane curvature
    Guillaume Drin
    Centre National de la Recherche Scientifique CNRS, Institut de Pharmacologie Moleculaire et Cellulaire, Universite de Nice Sophia Antipolis, 06560 Valbonne, France
    Nat Struct Mol Biol 14:138-46. 2007
    ..In the nucleoporin Nup133, the sensor corresponds to an exposed loop of a beta-propeller structure. Ser/Thr-rich amphipathic helices thus define a general motif used by proteins of various functions for sensing membrane curvature...
  71. ncbi A translocation signal for delivery of oomycete effector proteins into host plant cells
    Stephen C Whisson
    Plant Pathology Programme, Scottish Crop Research Institute, Invergowrie, Dundee DD2 5DA, UK
    Nature 450:115-8. 2007
    ..infestans genome. Identification of this class of proteins provides unparalleled opportunities to determine how oomycetes manipulate hosts to establish infection...
  72. pmc A structural-alphabet-based strategy for finding structural motifs across protein families
    Chih Yuan Wu
    Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan
    Nucleic Acids Res 38:e150. 2010
    ..Furthermore, DNA-specific motifs present 'only' in DBPs were discovered. The motifs found can provide useful guidelines in detecting binding sites and computational protein redesign...
  73. pmc Topological orientation of acyl-CoA:diacylglycerol acyltransferase-1 (DGAT1) and identification of a putative active site histidine and the role of the n terminus in dimer/tetramer formation
    Pamela J McFie
    Department of Biochemistry, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E5, Canada
    J Biol Chem 285:37377-87. 2010
    ..Finally, we show that the N-terminal domain of DGAT1 is not required for the catalytic activity of DGAT1 but, instead, may be involved in regulating enzyme activity and dimer/tetramer formation...
  74. pmc Analysis of the PDZ binding specificities of Influenza A virus NS1 proteins
    Miranda Thomas
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34012 Trieste, Italy
    Virol J 8:25. 2011
    ..In this study we analyse the effect of these differences upon the binding of Influenza A virus NS1 protein to a range of cellular proteins involved in polarity and signal transduction...
  75. doi LysM, a widely distributed protein motif for binding to (peptido)glycans
    Girbe Buist
    Department of Molecular Genetics, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands
    Mol Microbiol 68:838-47. 2008
    ..This interaction is triggered by chitin-like compounds that are secreted by the symbiotic bacteria or released from fungi, demonstrating an important sensing function of LysMs...
  76. pmc Large-scale discovery and characterization of protein regulatory motifs in eukaryotes
    Daniel S Lieber
    Department of Molecular Biology, Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
    PLoS ONE 5:e14444. 2010
    ..These predicted motifs, many of which display preferential association with specific biological pathways and non-random positioning in the linear protein sequence, provide focused hypotheses for experimental validation...
  77. pmc PML isoforms I and II participate in PML-dependent restriction of HSV-1 replication
    Delphine Cuchet
    MRC University of Glasgow Centre for Virus Research, Church Street, Glasgow G11 5JR, Scotland, UK
    J Cell Sci 124:280-91. 2011
    ..Our observations suggest that complete functionality of PML is dependent on isoform-specific C-terminal sequences acting in concert...
  78. pmc The GAPs, GEFs, and GDIs of heterotrimeric G-protein alpha subunits
    David P Siderovski
    Department of Pharmacology, UNC Lineberger Comprehensive Cancer Center, and UNC Neuroscience Center, The University of North Carolina at Chapel Hill, CB 7365, 1106 M E Jones Building, Chapel Hill, NC 27599 7365 USA
    Int J Biol Sci 1:51-66. 2005
    ..Discovery of these novel GAP, GDI, and GEF activities have helped to illuminate a new role for Galpha subunit GDP/GTP cycling required for microtubule force generation and mitotic spindle function in chromosomal segregation...
  79. pmc Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4
    C N Jolliffe
    Hanson Centre for Cancer Research, Institute of Medical and Veterinary Science, P O Box 14, Rundle Mall, Adelaide, SA 5000, Australia
    Biochem J 351:557-65. 2000
    ..These results provide evidence that Nedd4 can potentially interact with multiple proteins, possibly simultaneously, through its WW domains...
  80. doi CLEC-2 activates Syk through dimerization
    Craig E Hughes
    Centre for Cardiovascular Sciences, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK
    Blood 115:2947-55. 2010
    ..This is a unique mode of activation of Syk by a single YxxL-containing receptor...
  81. pmc Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte
    Ilaria Russo
    Howard Hughes Medical Institute, Washington University School of Medicine, Department of Molecular Microbiology, St Louis, Missouri 63110, USA
    Nature 463:632-6. 2010
    ..This enzyme is essential for parasite viability and ER residence is essential for its function. We propose that plasmepsin V is the PEXEL protease and is an attractive enzyme for antimalarial drug development...
  82. ncbi Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo
    Matthias Selbach
    Max Planck Institut für Infektionsbiologie, Abt Molekulare Biologie, Schumannstrasse 20 21, D 10117 Berlin, Germany
    J Biol Chem 277:6775-8. 2002
    ....
  83. pmc Tung tree DGAT1 and DGAT2 have nonredundant functions in triacylglycerol biosynthesis and are localized to different subdomains of the endoplasmic reticulum
    Jay M Shockey
    U S Department of Agriculture, Agricultural Research Service, Southern Regional Research Center, New Orleans, Louisiana 70124, USA
    Plant Cell 18:2294-313. 2006
    ..These data suggest that DGAT1 and DGAT2 have nonredundant functions in plants and that the production of storage oils, including those containing unusual fatty acids, occurs in distinct ER subdomains...
  84. pmc Structural basis for the sequence-specific RNA-recognition mechanism of human CUG-BP1 RRM3
    Kengo Tsuda
    RIKEN Systems and Structural Biology Center, Tsurumi, Japan
    Nucleic Acids Res 37:5151-66. 2009
    ....
  85. ncbi Crystal structure of a beta-catenin/Tcf complex
    T A Graham
    Department of Biological Structure University of Washington 98195, Seattle, WA, USA
    Cell 103:885-96. 2000
    ..The structural and mutagenesis data reveal a potential target for molecular drug design studies...
  86. pmc Human embryonic stem cell phosphoproteome revealed by electron transfer dissociation tandem mass spectrometry
    Danielle L Swaney
    Department of Chemistry, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 106:995-1000. 2009
    ..8% compared with 29.6%), and sequences whole classes of phosphopeptides previously unobserved...
  87. pmc HPV E6 and MAGUK protein interactions: determination of the molecular basis for specific protein recognition and degradation
    M Thomas
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, I-34012 Trieste, Italy
    Oncogene 20:5431-9. 2001
    ..Finally, in a series of comparative analyses, we show that the degradation of MAGI-1 occurs through a different mechanism from that used by the E6 protein to induce the degradation of Dlg and p53...
  88. doi Nuclear retention of fission yeast dicer is a prerequisite for RNAi-mediated heterochromatin assembly
    Stephan Emmerth
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Dev Cell 18:102-13. 2010
    ..Our findings suggest that Dicer proteins are shuttling proteins and that the steady-state subcellular levels can be shifted toward either compartment...
  89. ncbi Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
    Ana Maria Cuervo
    Department of Anatomy and Structural Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Science 305:1292-5. 2004
    ..These findings may underlie the toxic gain-of-function by the mutants...
  90. ncbi The DEAD-box protein family of RNA helicases
    Olivier Cordin
    Département de Microbiologie et Médecine Moléculaire, Centre Medical Universitaire, 1 rue Michel Servet, 1211, Geneve 4, Switzerland
    Gene 367:17-37. 2006
    ..This review will focus on the description of the molecular characteristics of members of the DEAD-box protein family and on the enzymatic activities they possess...
  91. pmc The mechanisms of PML-nuclear body formation
    Tian Huai Shen
    Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Cell 24:331-9. 2006
    ....
  92. pmc Quantifying similarity between motifs
    Shobhit Gupta
    Department of Genome Sciences, University of Washington, 1705 NE Pacific Street, Box 355065, Seattle, WA 98195, USA
    Genome Biol 8:R24. 2007
    ..Experimental simulations demonstrate the accuracy of Tomtom's E values and its effectiveness in finding similar motifs...
  93. ncbi Structural basis and functional consequence of Helicobacter pylori CagA multimerization in cells
    Shumei Ren
    Division of Molecular Oncology, Institute for Genetic Medicine, Hokkaido University, Kita 15 Nishi 7, Kita ku, Sapporo 060 0815, Japan
    J Biol Chem 281:32344-52. 2006
    ..The present work raises the possibility that inhibition of CagA multimerization abolishes pathophysiological activities of CagA that promote gastric carcinogenesis...
  94. ncbi Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs
    Kirsten Mattison
    Department of Biochemistry, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Biol Chem 281:37942-51. 2006
    ..Interactions between two FitB molecules result in the formation of a tetramer of FitAB heterodimers, which binds to the 36-bp DNA fragment and provides an explanation for how FitB enhances the DNA binding affinity of FitA...
  95. pmc Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control
    Bin Zhao
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    Genes Dev 21:2747-61. 2007
    ..Our observations demonstrate that YAP plays a key role in the Hippo pathway to control cell proliferation in response to cell contact...
  96. ncbi AAA+ ATPases: achieving diversity of function with conserved machinery
    Susan Roehl White
    Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Traffic 8:1657-67. 2007
    ..The importance of this mechanism to human health is demonstrated by the number of genetic diseases caused by mutant AAA+ proteins...
  97. ncbi Mechanisms of specificity in protein phosphorylation
    Jeffrey A Ubersax
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, California 94305 5174, USA
    Nat Rev Mol Cell Biol 8:530-41. 2007
    ..The responsibility for the recognition of substrates by protein kinases appears to be distributed among a large number of independent, imperfect specificity mechanisms...
  98. pmc Isolation and functional analysis of Arabidopsis stress-inducible NAC transcription factors that bind to a drought-responsive cis-element in the early responsive to dehydration stress 1 promoter
    Lam Son Phan Tran
    Biological Resources Division, Japan International Research Center for Agricultural Sciences, Tsukuba, Ibaraki 305 8686, Japan
    Plant Cell 16:2481-98. 2004
    ..However, erd1 was not upregulated in the transgenic plants. Other interacting factors may be necessary for the induction of erd1 in Arabidopsis under stress conditions...
  99. ncbi eIF4A: the godfather of the DEAD box helicases
    George W Rogers
    Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4935, USA
    Prog Nucleic Acid Res Mol Biol 72:307-31. 2002
    ....
  100. ncbi The ribosomal exit tunnel functions as a discriminating gate
    Hitoshi Nakatogawa
    Institute for Virus Research and CREST, Japan Science and Technology Corporation, Kyoto University, Japan
    Cell 108:629-36. 2002
    ..Thus, we suggest that this region of the exit tunnel interacts with nascent translation products and functions as a discriminating gate...
  101. ncbi Crystal structure of rhodopsin: A G protein-coupled receptor
    K Palczewski
    Department of Ophthalmology, University of Washington, Seattle, WA 98195, USA
    Science 289:739-45. 2000
    ..Identification of a set of residues that mediate interactions between the transmembrane helices and the cytoplasmic surface, where G-protein activation occurs, also suggests a possible structural change upon photoactivation...

Research Grants65

  1. Designing Spider Silk Proteins as Novel Biomaterials
    Randolph Lewis; Fiscal Year: 2005
    ..A number of spider silk genes have been cloned and sequenced revealing specific amino acid motifs that have been conserved for over 125 million years...
  2. Potentiation of Glycine Receptors by Ethanol
    LUIS GERARDO AGUAYO; Fiscal Year: 2010
    ..Specifically, using a series of GlyR mutants, the presence of basic amino acid motifs that are responsible for G beta gamma binding and receptor modulation were discovered...
  3. Potentiation of Glycine Receptors by Ethanol
    LUIS GERARDO AGUAYO; Fiscal Year: 2010
    ..Specifically, using a series of GlyR mutants, the presence of basic amino acid motifs that are responsible for G beta gamma binding and receptor modulation were discovered...
  4. Designing Spider Silk Proteins as Novel Biomaterials
    Randolph Lewis; Fiscal Year: 2007
    ..A number of spider silk genes have been cloned and sequenced revealing specific amino acid motifs that have been conserved for over 125 million years...
  5. Designing Spider Silk Proteins as Novel Biomaterials
    Randolph Lewis; Fiscal Year: 2009
    ..A number of spider silk genes have been cloned and sequenced revealing specific amino acid motifs that have been conserved for over 125 million years...
  6. THE ROLE OF EPSILON SUBUNIT IN GABAA RECEPTOR FUNCTION
    TIM HALES; Fiscal Year: 2003
    ..The subunit will be used to define the amino acid motifs involved in the regulation of GABAA receptor function by anesthetics...
  7. SIGNALING MECHANISMS OF SOMATOSTATIN RECEPTORS
    DIANE BARBER; Fiscal Year: 2002
    ..will be investigated by determining whether inhibition of NHE1 is mediated by receptor subtype-specific amino acid motifs, G alpha 12, and the novel NHE1-regulatory protein CHP, and by determining whether NHE1 and CHP mediate ..
  8. MOLECULAR CHARACTERIZATION OF ACYL-COA DEHYDROGENASES
    Gerard Vockley; Fiscal Year: 1993
    ..In vitro mutagenesis will be used to produce IVD mutants deficient in tetramerization in order to identify amino acid motifs and residues critical to this process...
  9. ENDONUCLEASES OF INTERRUPTED PROKARYOTIC GENES
    Marlene Belfort; Fiscal Year: 2002
    ..role of DNA binding in activity, and domains of the enzymes, particularly the function of the conserved amino acid motifs. They will perform biochemical characterization of the enzymes, and provide enzyme for atomic structure ..
  10. Glucuronidation of Fatty Acids by Human ER & Nuclear UGT
    Anna Radominska Pandya; Fiscal Year: 2002
    ..The structural domains of UGTs required for effective glucuronidation will be studied. Amino acid motifs localized in substrate binding sites or required for cellular targeting to the ER and nuclear membranes will ..
  11. Polycystin2 Function in Kidney Development
    Iain Drummond; Fiscal Year: 2007
    ..We hypothesize that specific amino acid motifs in polycystin2 target it to its cellular site of action...
  12. Structure-Function of UDP-Glucuronosyltransferases
    Anna Radominska Pandya; Fiscal Year: 2007
    ..3. To sequence photolabeled polypeptides by mass spectrometry. 4. To modify amino acid motifs of putative binding sites by site-directed mutagenesis and catalytically characterize the generated mutants...
  13. Structure-Function of UDP-Glucuronosyltransferases
    Anna Radominska Pandya; Fiscal Year: 2009
    ..3. To sequence photolabeled polypeptides by mass spectrometry. 4. To modify amino acid motifs of putative binding sites by site-directed mutagenesis and catalytically characterize the generated mutants...
  14. MOLECULAR MECHANISMS OF ALPHA 2,8-POLYSIALYTRANSFERASES
    FREDERIC TROY; Fiscal Year: 2001
    ..to be tested is that PST, STX and NeuS achieve the same catalytic functions by rearranging conserved amino acid motifs spatially in their active sites to bind CMP-Sia and initiate polySia chain synthesis while bound to the ..
  15. MINORITY PREDOCTORAL FELLOWSHIP PROGRAM
    ADRIENNE COTTRELL; Fiscal Year: 2007
    ..novel family of DNA recombinases, the Piv/MooV recombinase family, which does not share any of the conserved amino acid motifs found in the other DNA recombinase families...
  16. Botulinum Neurotoxin Substrate Specificity
    Neil Green; Fiscal Year: 2006
    ..abstract_text> ..
  17. Identification of targeting motifs in K+ channels
    Jacqueline Rivera; Fiscal Year: 2005
    ..We hypothesize that the peptide sequences of K+ channels contain amino acid motifs that target them to distinct neuronal compartments...
  18. ABC-transporter binding proteins and trafficking
    Daniel Ortiz; Fiscal Year: 2005
    ..The specific amino acid motifs in SPGP which mediate its association with interacting proteins will be identified using yeast two hybrid ..
  19. HOXA13 AMINO-TERMINAL FUNCTIONAL DOMAINS
    JEFFREY INNIS; Fiscal Year: 2004
    ..In Aim III we will use homologous recombination in ES cells to modify evolutionarily-conserved HOXA13 amino acid motifs known from work in Aim I to be critical for specific transcriptional activities in vitro...
  20. DOPAMINERGIC SIGNALING IN NEUROLOGICAL DISORDERS
    Anita Sidhu; Fiscal Year: 2005
    ..Using progressively shorter synthetic peptides directed against specific amino acid motifs of intracellular loops of the D1 and D5 receptor, we will map the domains through which D1 couples to G(s)..