clinical laboratory information systems


Summary: Information systems, usually computer-assisted, designed to store, manipulate, and retrieve information for planning, organizing, directing, and controlling administrative and clinical activities associated with the provision and utilization of clinical laboratory services.

Top Publications

  1. Pai M, Moffat K, Plumhoff E, Hayward C. Critical values in the coagulation laboratory: results of a survey of the North American Specialized Coagulation Laboratory Association. Am J Clin Pathol. 2011;136:836-41 pubmed publisher
    ..It also provides critical value medians and ranges for a wide range of tests. Laboratories without critical values or in the process of reviewing their values may find this survey of their peers useful. ..
  2. Genzen J, Tormey C. Pathology consultation on reporting of critical values. Am J Clin Pathol. 2011;135:505-13 pubmed publisher
    ..This article presents a hypothetical (yet fairly common) clinical case scenario regarding critical values and then provides an up-to-date discussion and review of the literature on the reporting of critical results. ..
  3. Dighe A, Jones J, Parham S, Lewandrowski K. Survey of critical value reporting and reduction of false-positive critical value results. Arch Pathol Lab Med. 2008;132:1666-71 pubmed publisher
    ..In this report, we also demonstrate that attention to preanalytic transport and processing issues can assist in minimizing this issue. ..
  4. Pantanowitz L, Henricks W, Beckwith B. Medical laboratory informatics. Clin Lab Med. 2007;27:823-43, vii pubmed
  5. Bossuyt X, Verweire K, Blanckaert N. Laboratory medicine: challenges and opportunities. Clin Chem. 2007;53:1730-3 pubmed
  6. Dighe A, Rao A, Coakley A, Lewandrowski K. Analysis of laboratory critical value reporting at a large academic medical center. Am J Clin Pathol. 2006;125:758-64 pubmed
    ..Factors leading to delays in critical value reporting are identified, and we describe approaches to improving this important operational and patient safety issue. ..
  7. Turner E, Bolton J. Required steps for the validation of a Laboratory Information Management System. Qual Assur. 2001;9:217-24 pubmed
    ..Proper validation of a LIMS will allow a laboratory to comply with regulations and also provide comprehensive documentation on the system that is necessary to troubleshoot future problems. ..
  8. Bauer D, Guerlain S, Brown P. The design and evaluation of a graphical display for laboratory data. J Am Med Inform Assoc. 2010;17:416-24 pubmed publisher
    ..Graphic displays have several advantages over numeric displays but are not always optimal. User, task and data characteristics should be considered when designing information displays. ..
  9. Ward M, Brandsema P, van Straten E, Bosman A. Electronic reporting improves timeliness and completeness of infectious disease notification, The Netherlands, 2003. Euro Surveill. 2005;10:27-30 pubmed
    ..3% of data field examined were complete compared with 81.3% in 2001. This study documents the benefits of electronic reporting of infectious disease surveillance data in terms of improved timeliness and completeness. ..

More Information


  1. Westbrook J, Georgiou A, Dimos A, Germanos T. Computerised pathology test order entry reduces laboratory turnaround times and influences tests ordered by hospital clinicians: a controlled before and after study. J Clin Pathol. 2006;59:533-6 pubmed
    ..The extent to which improvements translate into improved patient outcomes remains to be determined. A potentially limiting factor is clinicians' capacity to respond to, and make use of, faster test results. ..
  2. Nguyen T, Thorpe L, Makki H, Mostashari F. Benefits and barriers to electronic laboratory results reporting for notifiable diseases: the New York City Department of Health and Mental Hygiene experience. Am J Public Health. 2007;97 Suppl 1:S142-5 pubmed
    ..Although ELR streamlines data processing, electronic reporting has its own limitations. A more successful use of ELR can be achieved by understanding its strengths and limitations for different disease types. ..
  3. Dixon B, McGowan J, Grannis S. Electronic laboratory data quality and the value of a health information exchange to support public health reporting processes. AMIA Annu Symp Proc. 2011;2011:322-30 pubmed
    ..Data processed by the HIE were often more complete, suggesting that HIEs can support improvements to existing public health reporting processes. ..
  4. M ikantha N, Southwell B, Lautenbach E. Automated laboratory reporting of infectious diseases in a climate of bioterrorism. Emerg Infect Dis. 2003;9:1053-7 pubmed
    ..As illustrated, challenges encountered in deployment of existing electronic laboratory reporting systems could guide further refinement and advances in infectious disease surveillance. ..
  5. Crawford J, Stallone R, Zhang F, Gerolimatos M, Korologos D, Sweetapple C, et al. Laboratory surge response to pandemic (H1N1) 2009 outbreak, New York City metropolitan area, USA. Emerg Infect Dis. 2010;16:8-13 pubmed publisher
    ..The ability of System laboratories to rapidly increase to high-volume comprehensive diagnostics, including influenza A subtyping, provided key epidemiologic information for local and state public health departments. ..
  6. Kuperman G, Teich J, Tanasijevic M, Ma Luf N, Rittenberg E, Jha A, et al. Improving response to critical laboratory results with automation: results of a randomized controlled trial. J Am Med Inform Assoc. 1999;6:512-22 pubmed
    ..Information technologies that facilitate the transmission of important patient data can potentially improve the quality of care. ..
  7. Panackal A, M ikanatha N, Tsui F, McMahon J, Wagner M, Dixon B, et al. Automatic electronic laboratory-based reporting of notifiable infectious diseases at a large health system. Emerg Infect Dis. 2002;8:685-91 pubmed
    ..Automatic reporting was more rapid and as complete as conventional reporting. Using standardized coding and minimizing free text usage will increase the completeness of electronic laboratory-based reporting. ..
  8. Backer H, Bissell S, Vugia D. Disease reporting from an automated laboratory-based reporting system to a state health department via local county health departments. Public Health Rep. 2001;116:257-65 pubmed
    ..To optimize surveillance accuracy and completeness, reporting at all levels should be done via direct electronic data transfer. ..
  9. Howanitz J, Howanitz P. Laboratory results. Timeliness as a quality attribute and strategy. Am J Clin Pathol. 2001;116:311-5 pubmed
    ..All the steps from test ordering to results reporting should be monitored and steps taken to improve the processes. Various strategies to improve TAT at each step in the testing process are discussed. ..
  10. Zhou Q, He J, Liu J. [A study on the LIS and HIS integration]. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2008;25:1294-8 pubmed
  11. Warsinke A. Point-of-care testing of proteins. Anal Bioanal Chem. 2009;393:1393-405 pubmed publisher
    ..The review will illuminate some of the current methods employed in POCT for proteins and will discuss the outlook for techniques (e.g., electrochemical immunosensors) that could have a great impact on future POCT of proteins. ..
  12. Ishikawa K. [Summary of an electronic chart system in Anjo Kosei hospital and clinical laboratory system]. Rinsho Byori. 2006;54:145-52 pubmed
    ..At this symposium, I presented a summary of the electronic chart system and the inspection system that this House introduced concentrating on the particularly special functions. ..
  13. Staes C, Bennett S, Evans R, Narus S, Huff S, Sorensen J. A case for manual entry of structured, coded laboratory data from multiple sources into an ambulatory electronic health record. J Am Med Inform Assoc. 2006;13:12-5 pubmed
    ..We encountered regulatory, logistic, economic, and data quality issues that should be of interest to others developing similar applications. ..
  14. Yang D, Liu M, Huang P. [The current situation of clinical laboratory automation and its exploration on a preferred scheme]. Zhongguo Yi Liao Qi Xie Za Zhi. 2005;29:120-3 pubmed
    ..It analyses the problems and the preferred scheme which should be given careful consideration when a system is to be built in the hospital. ..
  15. Brender J, Schou Christensen J, McNair P. A case study on constructive assessment of bids to a call for tender. Stud Health Technol Inform. 2002;90:527-32 pubmed
    ..The present report describes the strategy and approach for the selection process, together with some results and lessons learned, while a parallel paper presents the tools applied. ..
  16. Lewandrowski K, Gregory K, MacMillan D. Assuring quality in point-of-care testing: evolution of technologies, informatics, and program management. Arch Pathol Lab Med. 2011;135:1405-14 pubmed publisher
    ..The critical skill set of POCT managers has also been identified. The POCT manager is now recognized as a true specialist in laboratory medicine. ..
  17. Bush R. Rob Bush of Orchard focuses on LIS trends. Interview by Dottie Dunham. MLO Med Lab Obs. 2004;36:32-3 pubmed
  18. Klein C. LIMS user acceptance testing. Qual Assur. 2003;10:91-106 pubmed
    ..This paper discusses key elements in facilitating the development and execution of a LIMS User Acceptance Test Plan (UATP). ..
  19. McCullough E, Sullivan C, Banning P, Goldfield N, Hughes J. Challenges and benefits of adding laboratory data to a mortality risk adjustment method. Qual Manag Health Care. 2011;20:253-62 pubmed publisher
    ..53%. This study supports the feasibility of linking laboratory data elements with claims-based administrative data to enhance ROM assessments. This linkage resulted in modest statistical improvement in a commonly used ROM model. ..
  20. Aller R. Adding up billing system offerings. CAP Today. 2002;16:33-6, 38, 40 passim pubmed
  21. Kozy W. BD Clinical Laboratory Solutions' president, William A. Kozy, actuates "black-belt" quality and "next-gen" planning. Interview by Celia Stevens. MLO Med Lab Obs. 2003;35:28-9 pubmed
  22. Garcia F, Harrison E, Wise C, Wolk D. Is your document control out of control? Complying with document control regulations. Clin Leadersh Manag Rev. 2003;17:255-62 pubmed
    ..Several software programs have merit and can be integrated into a clinical laboratory. ..
  23. Owens S, Wiehagen L, Kelly S, Piccoli A, Lassige K, Yousem S, et al. Initial experience with a novel pre-sign-out quality assurance tool for review of random surgical pathology diagnoses in a subspecialty-based university practice. Am J Surg Pathol. 2010;34:1319-23 pubmed publisher
    ..The tool is a useful quality assurance instrument and its prospective nature allows for the potential prevention of some serious errors. ..
  24. Tofukuji I. [Trends of utilization of information technologies in clinical laboratory and pathology domain]. Rinsho Byori. 2007;55:764-72 pubmed
    ..Pathologists and technical experts in Japanese laboratories are encouraged to join IHE activities to ensure good results. ..
  25. Raths D. ELINCS gets adopted. HL 7 is taking over ELINCS to ensure lab data and EHRs continue towards interoperability. Healthc Inform. 2007;24:20, 24 pubmed
  26. Ten Berg M, Huisman A, van den Bemt P, Schobben A, Egberts A, van Solinge W. Linking laboratory and medication data: new opportunities for pharmacoepidemiological research. Clin Chem Lab Med. 2007;45:13-9 pubmed
    ..Although recently established, we believe that UPOD broadens the opportunities for clinical pharmacoepidemiological research and can contribute to patient care from a laboratory perspective. ..
  27. Komatsu M, Nakamura A, Aihara M, Shimakawa K, Iwasaki M, Nagasaka Y, et al. [Application of the MIC breakpoints based on pharmacokinetics and pharmacodynamics parameter in the clinical laboratory]. Jpn J Antibiot. 2003;56:697-704 pubmed
    ..If this information is routinely reported to physicians from clinical laboratories, an appropriate dosing schedule could be proposed for various infectious cases. ..
  28. Chen T, Lin W, Lu P, Lin C, Lin S, Lin C, et al. Computer laboratory notification system via short message service to reduce health care delays in management of tuberculosis in Taiwan. Am J Infect Control. 2011;39:426-430 pubmed publisher
    ..039). Implementation of expedited AFB smear laboratory procedures and an automatic, real-time laboratory mobile notification system significantly decreased delays in the diagnosis and isolation of patients with active TB. ..
  29. Baldwin F. Testing, testing. Once and future roles for laboratory information systems meet present demands. Healthc Inform. 2004;21:75-8 pubmed
  30. Siddiqui S. Laboratory errors as judged by test request slips and test reports. J Coll Physicians Surg Pak. 2006;16:136-8 pubmed
  31. Aller R. Making a case for computers to 'talk the talk'. CAP Today. 2004;18:56-8, 60, 62 passim pubmed
  32. Johansen I, Rasmussen M. MedCom: laboratory test ordering--fully implemented nationwide in less than 3 years. Stud Health Technol Inform. 2012;174:29-33 pubmed
    ..Today more than 6.000.000 lab test orders (100%) are now handled electronically each year. The implementation process, the challenges: organizational and technically as well as outcome is described in the paper. ..
  33. Cook C, Wellik K, Kongable G, Shu J. Assessing inpatient glycemic control: what are the next steps?. J Diabetes Sci Technol. 2012;6:421-7 pubmed
    ..Hospitals and/or their representatives should be included in the discussion. For inpatient glucose control to remain a focus of interest, further dialogue and consensus on the topic are needed. ..
  34. Krishna N, Cunnion K. Role of molecular diagnostics in the management of infectious disease emergencies. Med Clin North Am. 2012;96:1067-78 pubmed publisher
    ..An added advantage of rapid diagnostic tests often not emphasized is the capability to rule out certain diagnoses for which unnecessary antimicrobial therapy may otherwise be instituted and/or continued. ..
  35. Valasek M, Thung I, Gollapalle E, Hodkoff A, Kelly K, Baumgartner J, et al. Overinterpretation is common in pathological diagnosis of appendix cancer during patient referral for oncologic care. PLoS ONE. 2017;12:e0179216 pubmed publisher
    ..Further studies are needed to determine the extent of this phenomenon and its potential clinical impact. ..
  36. Rollins G. Changing CPOE parameters dramatically lowers physician test ordering. Rep Med Guidel Outcomes Res. 2004;15:1, 5-7 pubmed
  37. Hovis K, Veillon D. HIPAA Privacy Rule: the debate continues. Clin Lab Sci. 2003;16:85-8 pubmed
  38. Huang Y, Chen W, Wu H, Chien H, Lin T, Chiang H, et al. Learning curve of a new hospital laboratory. The monitoring of computer-generated turnaround time of laboratory tests in an emergency department. Clin Chem Lab Med. 2003;41:1373-8 pubmed
    ..Computer-generated turnaround times for Emergency Department stat tests appear to be a useful tool for monitoring the quality of laboratory tests and can demonstrate the learning curve of a new hospital laboratory. ..
  39. Judge B. Cytology information system helps improve patient care. MLO Med Lab Obs. 2004;36:14, 16 pubmed
  40. Koppel R. Defending computerized physician order entry from its supporters. Am J Manag Care. 2006;12:369-70 pubmed
  41. Harty Golder B. Lost specimens. MLO Med Lab Obs. 2007;39:44 pubmed
  42. Schmidt R, Simmons K, Grimm E, Middlebrooks M, Changchien R. Integration of scanned document management with the anatomic pathology laboratory information system: analysis of benefits. Am J Clin Pathol. 2006;126:678-83 pubmed
    ..This simple, integrated SDMS is an excellent value in a practice like ours, and many of the benefits likely apply in other practice settings. ..
  43. Georgiou A, Morse W, Timmins W, Ray S, Westbrook J. The use of performance metrics to monitor the impact of CPOE on pathology laboratory services. Stud Health Technol Inform. 2008;136:291-6 pubmed
    ..Performance metrics, can be relevant for measuring and monitoring changes in communication processes. This is important with CPOE systems whose introduction can have unexpected consequences requiring early detection and action. ..
  44. Georgiou A, Greenfield T, Callen J, Westbrook J. Safety and efficiency considerations for the introduction of electronic ordering in a blood bank. Arch Pathol Lab Med. 2009;133:933-7 pubmed publisher
    ..There needs to be high levels of staff preparedness to minimize patient risk and optimize performance. ..
  45. Daniel Y, Witchlow B, Almeida A. Automated computer result reporting for haemoglobinopathy screening. Clin Lab Haematol. 2004;26:21-4 pubmed
    ..The ability to concentrate on potentially abnormal results will allow laboratories and health care workers more time to develop appropriate and timely frameworks to deal with abnormal results. ..
  46. Peterson L, Hacek D, Rolland D, Brossette S. Detection of a community infection outbreak with virtual surveillance. Lancet. 2003;362:1587-8 pubmed
  47. Vu T, Eberhardt U, Szöke S, Groenewald M, Robert V. A laboratory information management system for DNA barcoding workflows. Integr Biol (Camb). 2012;4:744-55 pubmed publisher
  48. Zarcone P, Nordenberg D, Meigs M, Merrick U, Jernigan D, Hinrichs S. Community-driven standards-based electronic laboratory data-sharing networks. Public Health Rep. 2010;125 Suppl 2:47-56 pubmed
    ..PHLIP is emerging as a model of accelerated innovation for the fields of laboratory science, technology, and public health. ..
  49. Hoch I, Heymann A, Kurman I, Valinsky L, Chodick G, Shalev V. Countrywide computer alerts to community physicians improve potassium testing in patients receiving diuretics. J Am Med Inform Assoc. 2003;10:541-6 pubmed
    ..The success of this reminder system encourages expansion to include more drug-laboratory interactions. Furthermore, direct alerts to patients at multiple organization/patient contact points are planned. ..
  50. Colangeli P, Ferrilli M, Quaranta F, Malizia E, Mbulu R, Mukete E, et al. Laboratory information management system: an example of international cooperation in Namibia. Vet Ital. 2012;48:241-51 pubmed
    ..It is a fundamental component of the Namibian veterinary information system. ..
  51. Meffre C, Larsen C, Perin A, Bouraoui L, Delarocque Astagneau E. Surveillance of screening for hepatitis C through the laboratory network RENA-VHC, France, 2000-2001. Euro Surveill. 2003;8:101-7 pubmed
    ..0% in 2001. This suggests that screening covered more people with little risk of acquiring HCV infection. The per-sons confirmed HCV positive were predominantly men (sex ratio 1.5) of which 31% were 30 to 39 years of age. ..
  52. . Potential effects of electronic laboratory reporting on improving timeliness of infectious disease notification--Florida, 2002-2006. MMWR Morb Mortal Wkly Rep. 2008;57:1325-8 pubmed
    ..In Florida, the benefits of ELR for reporting timeliness likely will vary by disease. ..
  53. Okada M. [Clinical laboratory guidelines beneficial for Japanese people]. Rinsho Byori. 2011;59:491-5 pubmed
    ..The guideline refers to many other clinical guidelines. However, in those guidelines, evidence about what to recommend is often lacking, misleading, or misinterpreted. These problems should be overcome in the near future. ..