- Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
D C Angus
Critical Care Medicine Division, Department of Anesthesiology and Critical Care Medicine, and the Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA
Crit Care Med 29:1303-10. 2001
..To determine the incidence, cost, and outcome of severe sepsis in the United States...
- The epidemiology of sepsis in the United States from 1979 through 2000
Greg S Martin
Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Emory University School of Medicine, Atlanta, USA
N Engl J Med 348:1546-54. 2003
..We investigated the epidemiology of sepsis in the United States, with specific examination of race and sex, causative organisms, the disposition of patients, and the incidence and outcome...
- Comorbidity measures for use with administrative data
MEDTAP International, Inc, Bethesda, MD 20814, USA
Med Care 36:8-27. 1998
..This study attempts to develop a comprehensive set of comorbidity measures for use with large administrative inpatient datasets...
- Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock
Section of Critical Care Medicine, Health Sciences Centre St Boniface Hospital, University of Manitoba, Winnipeg, MB, Canada
Crit Care Med 34:1589-96. 2006
..To determine the prevalence and impact on mortality of delays in initiation of effective antimicrobial therapy from initial onset of recurrent/persistent hypotension of septic shock...
- Sepsis in European intensive care units: results of the SOAP study
Jean Louis Vincent
Department of Intensive Care, Erasme Hospital, Free University of Brussels, Belgium
Crit Care Med 34:344-53. 2006
..To better define the incidence of sepsis and the characteristics of critically ill patients in European intensive care units...
- Acute renal failure in critically ill patients: a multinational, multicenter study
Department of Intensive Care, Austin Hospital, Melbourne, Australia
JAMA 294:813-8. 2005
- Acute kidney injury, mortality, length of stay, and costs in hospitalized patients
Glenn M Chertow
Division of Nephrology, Department of Medicine, University of California San Francisco, 94118 1211, USA
J Am Soc Nephrol 16:3365-70. 2005
The marginal effects of acute kidney injury on in-hospital mortality, length of stay (LOS), and costs have not been well described...
- Incidence and outcomes of acute lung injury
Gordon D Rubenfeld
Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, Seattle, WA 98104 2499, USA
N Engl J Med 353:1685-93. 2005
..Despite recent advances in our understanding of the mechanism and treatment of acute lung injury, its incidence and outcomes in the United States have been unclear...
- Early goal-directed therapy in the treatment of severe sepsis and septic shock
Department of Emergency Medicine, Henry Ford Health Systems, Case Western Reserve University, Detroit, MI 48202, USA
N Engl J Med 345:1368-77. 2001
..The purpose of this study was to evaluate the efficacy of early goal-directed therapy before admission to the intensive care unit...
- Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data
Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada
Med Care 43:1130-9. 2005
..Recognizing this, we conducted a multistep process to develop ICD-10 coding algorithms to define Charlson and Elixhauser comorbidities in administrative data and assess the performance of the resulting algorithms...
- Predictors of hospital mortality in the global registry of acute coronary events
Christopher B Granger
Division of Cardiology, University Medical Center, Durham, NC, USA
Arch Intern Med 163:2345-53. 2003
..Management of acute coronary syndromes (ACS) should be guided by an estimate of patient risk...
- The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis
Mitchell M Levy
Division of Pulmonary, Sleep and Critical Care Medicine Care Medicine, Brown University School of Medicine, Rhode Island Hospital, Providence, RI, USA
Crit Care Med 38:367-74. 2010
..A performance improvement initiative targeted changing clinical behavior (process improvement) via bundles based on key SSC guideline recommendations...
- Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study
Unidad de Cuidados Intensivos, Hospital Universitario de Getafe, Carretera de Toledo Km 12, 5, 28905 Getafe, Madrid, Spain
JAMA 287:345-55. 2002
..The outcome of patients receiving mechanical ventilation for particular indications has been studied, but the outcome in a large number of unselected, heterogeneous patients has not been reported...
- International study of the prevalence and outcomes of infection in intensive care units
Jean Louis Vincent
Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium
JAMA 302:2323-9. 2009
..Infection is a major cause of morbidity and mortality in intensive care units (ICUs) worldwide. However, relatively little information is available about the global epidemiology of such infections...
- Adverse events and potentially preventable deaths in Dutch hospitals: results of a retrospective patient record review study
NIVEL, Netherlands Institute for Health Services Research, Utrecht, The Netherlands
Qual Saf Health Care 18:297-302. 2009
..This study determined the incidence, type, nature, preventability and impact of adverse events (AEs) among hospitalised patients and potentially preventable deaths in Dutch hospitals...
- Serum lactate is associated with mortality in severe sepsis independent of organ failure and shock
Mark E Mikkelsen
Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Crit Care Med 37:1670-7. 2009
..e., refractory hypotension)...
- Nurse-staffing levels and the quality of care in hospitals
Department of Health Policy and Management, Harvard School of Public Health, Boston, Mass 02115, USA
N Engl J Med 346:1715-22. 2002
..It is uncertain whether lower levels of staffing by nurses at hospitals are associated with an increased risk that patients will have complications or die...
- Characteristics and outcomes of patients hospitalized for heart failure in the United States: rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE)
Kirkwood F Adams
Division of Cardiology, University of North Carolina, Chapel Hill, NC, USA
Am Heart J 149:209-16. 2005
..Most available data on these patients are limited by patient selection criteria and study design of clinical trials and single-center studies...
- Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine
J L Vincent
Department of Intensive Care, Erasme University Hospital, Brussels, Belgium
Crit Care Med 26:1793-800. 1998
..To evaluate the use of the Sequential Organ Failure Assessment (SOFA) score in assessing the incidence and severity of organ dysfunction in critically ill patients...
- Risk factors and outcome in European cardiac surgery: analysis of the EuroSCORE multinational database of 19030 patients
Service de chirurgie cardiovasculaire, CHU de Fort de France, Martinique, France
Eur J Cardiothorac Surg 15:816-22; discussion 822-3. 1999
..To assess risk factors for mortality in cardiac surgical adult patients as part of a study to develop a European System for Cardiac Operative Risk Evaluation (EuroSCORE)...
- Evidence of methodological bias in hospital standardised mortality ratios: retrospective database study of English hospitals
Mohammed A Mohammed
Unit of Public Health, Epidemiology and Biostatistics, University of Birmingham, Birmingham B15 2TT
BMJ 338:b780. 2009
..To assess the validity of case mix adjustment methods used to derive standardised mortality ratios for hospitals, by examining the consistency of relations between risk factors and mortality across hospitals...
- Hospitalized patients with 2009 H1N1 influenza in the United States, April-June 2009
Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
N Engl J Med 361:1935-44. 2009
..We describe the clinical characteristics of patients who were hospitalized with 2009 H1N1 influenza in the United States from April 2009 to mid-June 2009...
- Hospital nurse staffing and patient mortality, nurse burnout, and job dissatisfaction
Linda H Aiken
Center for Health Outcomes and Policy Research, School of Nursing, University of Pennsylvania, 420 Guardian Dr, Philadelphia, PA 19104 6096, USA
JAMA 288:1987-93. 2002
- Hospital volume and surgical mortality in the United States
John D Birkmeyer
Veterans Affairs Outcomes Group, Department of Veterans Affairs Medical Center, White River Junction, VT 05009, USA
N Engl J Med 346:1128-37. 2002
..Although numerous studies suggest that there is an inverse relation between hospital volume of surgical procedures and surgical mortality, the relative importance of hospital volume in various surgical procedures is disputed...
- Developing a summary hospital mortality index: retrospective analysis in English hospitals over five years
Michael J Campbell
ScHARR, University of Sheffield, Sheffield S1 4DA, UK
BMJ 344:e1001. 2012
- Sepsis incidence and outcome: contrasting the intensive care unit with the hospital ward
Intensive Care Unit, Hospital Universitario de Getafe, Madrid, Spain
Crit Care Med 35:1284-9. 2007
..To describe the outcome of patients with sepsis according to location on a ward or in an intensive care unit...
- Comparison of the Elixhauser and Charlson/Deyo methods of comorbidity measurement in administrative data
Danielle A Southern
Department of Community Health Sciences and The Centre for Health and Policy Studies, University of Calgary, Calgary, Alberta, Canada
Med Care 42:355-60. 2004
..However, a new method defined by Elixhauser et al. has been introduced recently and could be superior, although it has not been validated widely...
- Weekend mortality for emergency admissions. A large, multicentre study
Dr Foster Unit at Imperial College, Department of Primary Care and Social Medicine, Imperial College London, London SW7 2AZ, UK
Qual Saf Health Care 19:213-7. 2010
..Several studies have identified higher mortality for patients admitted as emergencies at the weekend compared with emergency admissions during the week, but most have focused on specific conditions or have had a limited sample size...
- A national evaluation of the effect of trauma-center care on mortality
Ellen J MacKenzie
Johns Hopkins Bloomberg School of Public Health, Center for Injury Research and Policy, Baltimore, MD 21205 1996, USA
N Engl J Med 354:366-78. 2006
..To address this gap, we examined differences in mortality between level 1 trauma centers and hospitals without a trauma center (non-trauma centers)...
- Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome
Kenneth P Steinberg
Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, Box 359762, 325 Ninth Ave, Seattle, WA 98104, USA
N Engl J Med 354:1671-84. 2006
..Because previous reports suggested that corticosteroids may improve survival, we performed a multicenter, randomized controlled trial of corticosteroids in patients with persistent ARDS...
- The association between hospital overcrowding and mortality among patients admitted via Western Australian emergency departments
Peter C Sprivulis
Department of Emergency Medicine, University of Western Australia, 2nd Floor R Block, Queen Elizabeth II, Medical Centre, Verdun Street, Nedlands, WA 6009, Australia
Med J Aust 184:208-12. 2006
..To examine the relationship between hospital and emergency department (ED) occupancy, as indicators of hospital overcrowding, and mortality after emergency admission...
- Acute kidney injury and mortality in hospitalized patients
Henry E Wang
Department of Emergency Medicine, University of Alabama at Birmingham, Birmingham, AL 35249, USA
Am J Nephrol 35:349-55. 2012
..The objective of this study was to determine the incidence of acute kidney injury (AKI) and its relation with mortality among hospitalized patients...
- The DECAF Score: predicting hospital mortality in exacerbations of chronic obstructive pulmonary disease
Department of Respiratory Medicine, North Tyneside General Hospital, Rake Lane, North Shields, UK
Thorax 67:970-6. 2012
..For exacerbations complicated by pneumonia, the CURB-65 prognostic tool is frequently used but its use in this population is suboptimal...
- Mortality among patients admitted to hospitals on weekends as compared with weekdays
C M Bell
Department of Medicine, University of Toronto, Sunnybrook and Women's College Health Sciences Centre, ON, Canada
N Engl J Med 345:663-8. 2001
..It is uncertain whether in-hospital mortality rates among patients with serious conditions differ according to whether they are admitted on a weekend or ..
- The EuroHeart Failure survey programme-- a survey on the quality of care among patients with heart failure in Europe. Part 1: patient characteristics and diagnosis
J G F Cleland
Department of Cardiology, University of Hull, Castle Hill Hospital, Castle Road, Kingston upon Hull HU16 5JQ UK
Eur Heart J 24:442-63. 2003
..Accordingly, the EuroHeart Failure survey was conducted to ascertain if appropriate tests were being performed with which to confirm or refute a diagnosis of heart failure and how this influenced subsequent management...
- Hospital mortality, length of stay, and preventable complications among critically ill patients before and after tele-ICU reengineering of critical care processes
Craig M Lilly
Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
JAMA 305:2175-83. 2011
The association of an adult tele-intensive care unit (ICU) intervention with hospital mortality, length of stay, best practice adherence, and preventable complications for an academic medical center has not been reported.
- Impact of a statewide intensive care unit quality improvement initiative on hospital mortality and length of stay: retrospective comparative analysis
Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, 624 N Broadway, Baltimore, MD 21205, USA
BMJ 342:d219. 2011
..ICU project, a comprehensive statewide quality improvement initiative focused on reduction of infections, was associated with reductions in hospital mortality and length of stay for adults aged 65 or more admitted to intensive care units.
- The more the better?: the impact of surgeon and hospital volume on in-hospital mortality following colorectal resection
Paul J Karanicolas
Department of Surgery, The University of Western Ontario, London, Canada
Ann Surg 249:954-9. 2009
To determine the in-hospital mortality rates for patients undergoing colorectal resection for malignant or benign conditions, and to identify risk factors for in-hospital death, particularly the relationships with surgeon and hospital ..
- Effect of acute renal failure requiring renal replacement therapy on outcome in critically ill patients
Philipp G H Metnitz
Department of Reanimation Medicale, Hopital St Louis, University Lariboisière St Louis, Paris, France
Crit Care Med 30:2051-8. 2002
..renal failure is a complication in critically ill patients that has been associated with an excess risk of hospital mortality. Whether this reflects the severity of the disease or whether acute renal failure is an independent risk ..
- Is worsening multiple organ failure the cause of death in patients with severe sepsis?
Jean Louis Vincent
Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Belgium
Crit Care Med 39:1050-5. 2011
..We used the INDEPTH (International Integrated Database for the Evaluation of Severe Sepsis and Drotrecogin alfa activated) database to investigate the reported cause of death in patients with severe sepsis...
- An administrative claims model for profiling hospital 30-day mortality rates for pneumonia patients
Dale W Bratzler
Oklahoma Foundation for Medical Quality, Oklahoma City, Oklahoma, United States of America
PLoS ONE 6:e17401. 2011
..We sought to develop and validate a hierarchical regression model using Medicare claims data that produces hospital-level, risk-standardized 30-day mortality rates useful for public reporting for patients hospitalized with pneumonia...
- EuroHeart Failure Survey II (EHFS II): a survey on hospitalized acute heart failure patients: description of population
Markku S Nieminen
Division of Cardiology, Department of Medicine, Helsinki University Central Hospital, Haartmaninkatu 4, PO Box 340, 00029 HUS, Finland
Eur Heart J 27:2725-36. 2006
- Brazilian Sepsis Epidemiological Study (BASES study)
Intensive Care Unit, Hospital Israelita Albert Einstein, Sao Paulo, Brazil
Crit Care 8:R251-60. 2004
..This study was designed to verify the actual incidence density and outcome of sepsis in Brazilian ICUs. We also assessed the association between the Consensus Conference criteria and outcome..
- Nonrecovery of kidney function and death after acute on chronic renal failure
Chi yuan Hsu
Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0532, USA
Clin J Am Soc Nephrol 4:891-8. 2009
..Relatively little is known about clinical outcomes, especially long-term outcomes, among patients who have chronic kidney disease (CKD) and experience superimposed acute renal failure (ARF; acute on chronic renal failure)...
- An administrative claims model suitable for profiling hospital performance based on 30-day mortality rates among patients with heart failure
Harlan M Krumholz
Department of Medicine, Yale University School of Medicine, New Haven, CT 06520 8088, USA
Circulation 113:1693-701. 2006
..A model using administrative claims data that is suitable for profiling hospital performance for heart failure would be useful in quality assessment and improvement efforts...
- New ICD-10 version of the Charlson comorbidity index predicted in-hospital mortality
Victorian Department of Human Services, Level 18, 120 Spencer Street, Melbourne, 3000 Victoria, Australia
J Clin Epidemiol 57:1288-94. 2004
..With the transition into ICD-10 coding worldwide, an ICD-10 version of the Deyo adaptation was developed and validated using population-based hospital data from Victoria, Australia...
- Quality of care information makes a difference: an analysis of market share and price changes after publication of the New York State Cardiac Surgery Mortality Reports
D B Mukamel
Department of Community and Preventive Medicine, University of Rochester Medical Center, NY, USA
Med Care 36:945-54. 1998
..The authors test the hypotheses that hospitals and surgeons with better outcomes reported in the NYS Cardiac Surgery Reports experience a relative increase in their market share and prices...
- Acute renal failure in hospitalized patients with HIV: risk factors and impact on in-hospital mortality
Christina M Wyatt
Division of Nephrology, Department of Medicine, Mount Sinai Medical Center, New York, NY 10029 6574, USA
AIDS 20:561-5. 2006
..Kidney disease is an increasingly important complication of HIV...
- The Canadian Adverse Events Study: the incidence of adverse events among hospital patients in Canada
G Ross Baker
Department of Health Policy, Management and Evaluation, University of Toronto, McMurrich Building Room 2031, 12 Queen s Park Crescent West, Toronto, Ontario M5S 1A8, Canada
CMAJ 170:1678-86. 2004
..AEs are unintended injuries or complications resulting in death, disability or prolonged hospital stay that arise from health care management. We estimated the incidence of AEs among patients in Canadian acute care hospitals...
- Predictors of in-hospital mortality and attributable risks of death after ischemic stroke: the German Stroke Registers Study Group
Peter U Heuschmann
Institute of Epidemiology and Social Medicine, University of Muenster, Muenster, Germany
Arch Intern Med 164:1761-8. 2004
..We investigated predictors for in-hospital mortality and attributable risks of death after ischemic stroke in a pooled analysis of large German stroke registers.
- Use of comorbidity scores for control of confounding in studies using administrative databases
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Int J Epidemiol 29:891-8. 2000
..Our objective was to compare metrical and practical properties of published comorbidity scores for use in epidemiological research with administrative databases...
- Variation in hospital mortality associated with inpatient surgery
Amir A Ghaferi
Michigan Surgical Collaborative for Outcomes Research and Evaluation, The Department of Surgery, University of Michigan, Ann Arbor 48104, USA
N Engl J Med 361:1368-75. 2009
b>Hospital mortality that is associated with inpatient surgery varies widely. Reducing rates of postoperative complications, the current focus of payers and regulators, may be one approach to reducing mortality...
- Effects of nurse staffing and nurse education on patient deaths in hospitals with different nurse work environments
Linda H Aiken
Center for Health Outcomes and Policy Research, School of Nursing, University of Pennsylvania, PA 19104 4217, USA
Med Care 49:1047-53. 2011
..more educated nurses, and improved nurse work environments have been shown to be associated with lower hospital mortality. Little is known about whether and under what conditions each type of investment works better to improve ..
- A validated risk score for in-hospital mortality in patients with heart failure from the American Heart Association get with the guidelines program
Pamela N Peterson
Denver Health Medical Center, Denver, CO, USA
Circ Cardiovasc Qual Outcomes 3:25-32. 2010
..Our objective was to derive and validate a risk score for in-hospital mortality in patients hospitalized with heart failure using American Heart Association Get With the Guidelines-Heart ..
- Severe bloodstream infections: a population-based assessment
Kevin B Laupland
Department of Critical Care Medicine, University of Calgary, Calgary Health Region, and Calgary Laboratory Services, Calgary, Alberta, Canada
Crit Care Med 32:992-7. 2004
..We sought to define the incidence and microbiology of severe bloodstream infection (bloodstream infection associated with intensive care unit admission within 48 hrs) and assess risk factors for acquisition and death...
- The hospital standardised mortality ratio: a powerful tool for Dutch hospitals to assess their quality of care?
Dr Foster Unit, Faculty of Medicine, Imperial College London EC1A 9LA, UK
Qual Saf Health Care 19:9-13. 2010
..To use the hospital standardised mortality ratio (HSMR), as a tool for Dutch hospitals to analyse their death rates by comparing their risk-adjusted mortality with the national average...
- Factors influencing in-hospital mortality and morbidity in patients treated on a stroke unit
Hans Christian Koennecke
Department of Neurology, Vivantes Klinikum im Friedrichshain, Berlin, Germany
Neurology 77:965-72. 2011
To determine the extent that demographics, clinical characteristics, comorbidities, and complications contribute to the risk of in-hospital mortality and morbidity in acute stroke.
- Effects of the introduction of the WHO "Surgical Safety Checklist" on in-hospital mortality: a cohort study
W A Van Klei
Division of Perioperative Care and Emergency Medicine, University Medical Centre Utrecht, Utrecht, NL
Ann Surg 255:44-9. 2012
..To evaluate the effect of implementation of the WHO's Surgical Safety Checklist on mortality and to determine to what extent the potential effect was related to checklist compliance...
- Association of age and sex with myocardial infarction symptom presentation and in-hospital mortality
John G Canto
Watson Clinic and Lakeland Regional Medical Center, Lakeland, Florida 33805, USA
JAMA 307:813-22. 2012
..However, few studies have taken age into account when examining sex differences in clinical presentation and mortality...
- Severe sepsis in two Ugandan hospitals: a prospective observational study of management and outcomes in a predominantly HIV-1 infected population
Shevin T Jacob
Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA, USA
PLoS ONE 4:e7782. 2009
..We conducted a prospective observational study reporting the management and outcomes of severely septic patients in two Ugandan hospitals. We describe their epidemiology, management, and clinical correlates for mortality...
- Female gender is an independent predictor of in-hospital mortality after STEMI in the era of primary PCI: insights from the greater Paris area PCI Registry
European Hospital of Paris La Roseraie, Aubervilliers, France
EuroIntervention 6:1073-9. 2011
To determine if female gender is an independent predictor of in-hospital mortality after percutaneous coronary intervention (PCI) for ST segment elevation myocardial infarction (STEMI)...
- The association of registered nurse staffing levels and patient outcomes: systematic review and meta-analysis
Robert L Kane
University of Minnesota School of Public Health, Minneapolis, Minnesota 55455, USA
Med Care 45:1195-204. 2007
..To examine the association between registered nurse (RN) staffing and patient outcomes in acute care hospitals...
- Hospital standardized mortality ratio: consequences of adjusting hospital mortality with indirect standardization
Maurice E Pouw
Department of Anesthesiology, University Medical Center Utrecht, Utrecht, The Netherlands
PLoS ONE 8:e59160. 2013
..Different methods can be used to standardize the hospital mortality ratio...
- Evaluation of SOFA-based models for predicting mortality in the ICU: A systematic review
Department of Medical Informatics, Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands
Crit Care 12:R161. 2008
..To systematically review studies evaluating the performance of Sequential Organ Failure Assessment (SOFA)-based models for predicting mortality in patients in the intensive care unit (ICU)...
- Risk factors for in-hospital mortality of visceral leishmaniasis patients in eastern Uganda
Medecins Sans Frontieres, Geneva, Switzerland
Trop Med Int Health 14:910-7. 2009
To identify risk factors for in-hospital mortality in patients treated for visceral leishmaniasis (VL) in Uganda.
- Promoting Global Research Excellence in Severe Sepsis (PROGRESS): lessons from an international sepsis registry
Adult Intensive Care Unit, Guy s and St Thomas NHS Foundation Trust, St Thomas Hospital, Lambeth Palace Road, SE1 7EH, London, UK
Infection 37:222-32. 2009
- Medical Emergency Triage and Treatment System (METTS): a new protocol in primary triage and secondary priority decision in emergency medicine
Bengt R Widgren
Department of Accident and Emergency Medicine, Sahlgrenska University Hospital, Goteborg, Sweden
J Emerg Med 40:623-8. 2011
..In many Emergency Department (ED) triage scoring systems, vital signs are not included as an assessment parameter...
- Serum lactate as a predictor of mortality in emergency department patients with infection
Nathan I Shapiro
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Ann Emerg Med 45:524-8. 2005
..We determine whether a serum venous lactate is associated with an increased risk of death in ED patients with infection...
- Occult hypoperfusion and mortality in patients with suspected infection
Michael D Howell
Beth Israel Deaconess Medical Center and Harvard Medical School, Department of Medicine, KB 23, 330 Brookline Avenue, Boston, MA 02215, USA
Intensive Care Med 33:1892-9. 2007
To determine, in the early stages of suspected clinically significant infection, the independent relationship of the presenting venous lactate level to 28-day in-hospital mortality.
- Cytokine production and hospital mortality in patients with sepsis-induced stress hyperglycemia
Department of Internal Medicine, Section of Infectious Diseases, Patras University Hospital, Rion Patras 26500, Greece
J Infect 55:340-6. 2007
To investigate whether stress hyperglycemia affects the production of the main pro- and anti-inflammatory cytokines and the 28-day hospital mortality in patients with severe sepsis.
- Nurse staffing and inpatient hospital mortality
Department of Health Services, University of California, Los Angeles, School of Public Health, Los Angeles, USA
N Engl J Med 364:1037-45. 2011
..However, such studies have been criticized because they have not shown a direct link between the level of staffing and individual patient experiences and have not included sufficient statistical controls...
- SAPS 3--From evaluation of the patient to evaluation of the intensive care unit. Part 2: Development of a prognostic model for hospital mortality at ICU admission
Rui P Moreno
Unidade de Cuidados Intensivos Polivalente, Hospital de St António dos Capuchos, Centro Hospitalar de Lisboa zona central, Lisbon, Portugal
Intensive Care Med 31:1345-55. 2005
..To develop a model to assess severity of illness and predict vital status at hospital discharge based on ICU admission data...
- Hospitalized community-acquired pneumonia in the elderly: age- and sex-related patterns of care and outcome in the United States
Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Am J Respir Crit Care Med 165:766-72. 2002
..The sex differences are of concern and require further investigation...
- Patients readmitted to ICUs* : a systematic review of risk factors and outcomes
A L Rosenberg
Department of Anesthesiology and Critical Care, University of Michigan Medical Center, Ann Arbor 48109, USA
Chest 118:492-502. 2000
..To evaluate the causes, risk factors, and mortality rates associated with unexpected readmission to medical and surgical ICUs...
- Health care-associated pneumonia and community-acquired pneumonia: a single-center experience
Scott T Micek
Department of Pharmacy, Barnes Jewish Hospital, St Louis, MO, USA
Antimicrob Agents Chemother 51:3568-73. 2007
..8%), methicillin-sensitive Staphylococcus aureus (13.8%), and Haemophilus influenzae (8.5%). The hospital mortality rate was statistically greater among patients with HCAP than among those with CAP (24.6% versus 9...
- Trends in hospital volume and operative mortality for high-risk surgery
Jonathan F Finks
Center for Healthcare Outcomes and Policy and the Section of General Surgery, Department of Surgery, University of Michigan, Ann Arbor, USA
N Engl J Med 364:2128-37. 2011
..It remains unknown whether referral patterns for high-risk surgery have changed as a result and how operative mortality has been affected...
- Early lactate-guided therapy in intensive care unit patients: a multicenter, open-label, randomized controlled trial
Tim C Jansen
Department of Intensive Care, Erasmus MC University Medical Centre, Rotterdam, The Netherlands
Am J Respir Crit Care Med 182:752-61. 2010
..It is unknown whether lactate monitoring aimed to decrease levels during initial treatment in critically ill patients improves outcome...
- Site of bleeding and early outcome in primary intracerebral hemorrhage
Acute Stroke Unit, Department of Neurology, Hospital del Sagrat Cor, Barcelona, Spain
Acta Neurol Scand 105:282-8. 2002
..To describe the influence of the site of the bleeding on clinical spectrum and early outcome of patients with acute spontaneous intracerebral hemorrhage (ICH)...
- A multi-centre evaluation of the RIFLE criteria for early acute kidney injury in critically ill patients
Sean M Bagshaw
Division of Critical Care Medicine, University of Alberta Hospital, 3C1 16 Walter C Mackenzie Centre, 8440 122 Street, Edmonton, Alberta T6G2B7, Canada
Nephrol Dial Transplant 23:1203-10. 2008
..We sought to evaluate the RIFLE criteria on the day of ICU admission in a large heterogenous population of critically ill patients...
- Sex differences in medical care and early death after acute myocardial infarction
Division of Cardiology, Michael E DeBakey VA Medical Center and Baylor College of Medicine, 2002 Holcombe Blvd, Houston, TX 77030, USA
Circulation 118:2803-10. 2008
..It is unclear whether efforts undertaken to improve AMI care have mitigated these sex disparities in the current era...
- Effect of age, polymicrobial disease, and maternal HIV status on treatment response and cause of severe pneumonia in South African children: a prospective descriptive study
Lisa M McNally
Centre for International Child Health and Development, Institute of Child Health, University College London, London WC1N 1EH, UK
Lancet 369:1440-51. 2007
..We aimed to measure predictors of treatment failure and the cause of non-responsive pneumonia in children admitted to hospital with severe pneumonia in Durban, South Africa...
- Association between clinically abnormal observations and subsequent in-hospital mortality: a prospective study
Department of Intensive Care, Dandenong Hospital, P O Box 478, Dandenong, VIC 3175, Australia
Resuscitation 62:137-41. 2004
..Previous studies have suggested that a medical emergency team responding to such patients may decrease in-hospital mortality from cardiac arrest, but the association between any abnormal clinical observation and subsequent increased ..
- The epidemiology of severe sepsis in children in the United States
R Scott Watson
Department of Critical Care Medicine, Center for Research on Health Care, and the CRISMA Clinical Research, Investigation, and Systems Modeling of Acute Illness Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
Am J Respir Crit Care Med 167:695-701. 2003
..60 versus 0.52 per 1,000, p < 0.001). Hospital mortality was 10.3%, or 4,383 deaths nationally (6.2 per 100,000 population)...
- Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients
M H Kollef
Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
Chest 115:462-74. 1999
To evaluate the relationship between inadequate antimicrobial treatment of infections (both community-acquired and nosocomial infections) and hospital mortality for patients requiring ICU admission.
- Prognosis of patients on extracorporeal membrane oxygenation: the impact of acute kidney injury on mortality
Yung Chang Chen
Kidney Research Center, Department of Nephrology, Chang Gung Memorial Hospital, Taipei, Taiwan
Ann Thorac Surg 91:137-42. 2011
- Baseline characteristics, management practices, and long-term outcomes of Middle Eastern patients in the Second Gulf Registry of Acute Coronary Events (Gulf RACE-2)
Khalid F AlHabib
King Fahad Cardiac Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia
Ann Saudi Med 32:9-18. 2012
..We evaluated the clinical features, management, in-hospital, and long-term outcomes of in such a population...
- Epidemiology of critical care syndromes, organ failures, and life-support interventions in a suburban US community
Multidisciplinary Epidemiology and Translational Research in Intensive Care M E T R I C, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA
Chest 140:1447-55. 2011
..We aimed to determine the incidence of critical care syndromes, organ failures, and life-support interventions in a defined US suburban community with unrestricted access to critical care services...
- Representativeness of the Get With The Guidelines-Stroke Registry: comparison of patient and hospital characteristics among Medicare beneficiaries hospitalized with ischemic stroke
Mathew J Reeves
Department of Epidemiology, Michigan State University, B601 West Fee Hall, East Lansing, Michigan 48824, USA
Stroke 43:44-9. 2012
..We used fee-for-service Medicare claims to ascertain the representativeness of ischemic stroke admissions in GWTG-Stroke...
- Trends in presenting characteristics and hospital mortality among patients with ST elevation and non-ST elevation myocardial infarction in the National Registry of Myocardial Infarction from 1990 to 2006
William J Rogers
University of Alabama Medical Center, Birmingham, AL 35294, USA
Am Heart J 156:1026-34. 2008
..have been the focus of intense clinical investigation, limited information exists on characteristics and hospital mortality of patients not enrolled in clinical trials...
- The impact of weekends on outcome for acute exacerbations of COPD
Depts of Internal Medicine, Hospital Infanta Cristina, Avda 9 Junio no 2, 28981, Parla, Madrid, Spain
Eur Respir J 39:46-50. 2012
..Weekend admissions were associated with a significantly higher in-hospital mortality (12.9%) than weekday admissions (12.1%) among COPD patients (OR 1.07 (95% CI 1.04-1.10))...
- Impact of age on treatment and outcomes in ST-elevation myocardial infarction
Marc C Newell
Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital, Minneapolis, MN 55407, USA
Am Heart J 161:664-72. 2011
..We hypothesized that older patients in a regional ST-elevation myocardial infarction (STEMI) transfer program would attain comparable treatment to younger patients...
- An emergency department septic shock protocol and care guideline for children initiated at triage
Gitte Y Larsen
Pediatric Critical Care, Primary Children s Medical Center, Salt Lake City, UT 84158 0289, USA
Pediatrics 127:e1585-92. 2011
..Unrecognized and undertreated septic shock increases morbidity and mortality. Septic shock in children is defined as sepsis and cardiovascular organ dysfunction, not necessarily with hypotension...
- Comparison of hospital risk-standardized mortality rates calculated by using in-hospital and 30-day models: an observational study with implications for hospital profiling
Elizabeth E Drye
Yale University School of Medicine, Yale New Haven Hospital Center for Outcomes Research and Evaluation, New Haven, Connecticut 06510, USA
Ann Intern Med 156:19-26. 2012
In-hospital mortality measures, which are widely used to assess hospital quality, are not based on a standardized follow-up period and may systematically favor hospitals with shorter lengths of stay (LOSs).
- Comparison of 30-day mortality models for profiling hospital performance in acute ischemic stroke with vs without adjustment for stroke severity
Gregg C Fonarow
Division of Cardiology, University of California, Los Angeles, USA
JAMA 308:257-64. 2012
- Impact of HAART advent on admission patterns and survival in HIV-infected patients admitted to an intensive care unit
Infectious Diseases Intensive Care Unit and the Epidemiology and Biostatistics Department, Bichat Claude Bernard University Hospital, Paris, France
AIDS 18:1429-33. 2004
..Several studies found increased survival times and decreased hospitalization rates since the introduction of highly active antiretroviral therapy (HAART)...
- Comparison of men and women with acute coronary syndrome in six Middle Eastern countries
Department of Cardiology, Hamad Medical Corporation Hospital, Doha, Qatar
Am J Cardiol 104:1018-22. 2009
..not only ranked higher on Global Registry of Acute Coronary Events risk score but also had increased in-hospital mortality, 1.75 times that of men...
- Significant decrease in in-hospital mortality and major adverse cardiac events in Swiss STEMI patients between 2000 and December 2007
Valérie Stolt Steiger
Division of Cardiology, Hopital Cantonal, Fribourg, Switzerland
Swiss Med Wkly 139:453-7. 2009
To evaluate the in-hospital outcome of STEMI (ST elevation myocardial infarction) patients admitted to Swiss hospitals between 2000 and December 2007, and to identify the predictors of in-hospital mortality and major cardiac events.
- Effect of hospital volume on clinical outcome in patients with acute pancreatitis, based on a national administrative database
Department of Preventive Medicine and Community Health, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
Pancreas 40:1018-23. 2011
..This study aimed to investigate the relationship between hospital volume and clinical outcome in patients with acute pancreatitis, using a Japanese national administrative database...
- Using hospital standardised mortality ratios to assess quality of care--proceed with extreme caution
Ian A Scott
Department of Internal Medicine and Clinical Epidemiology, Princess Alexandra Hospital, Brisbane, QLD, Australia
Med J Aust 194:645-8. 2011
..It may be better suited to monitoring changes in outcomes over time within individual institutions...
- The New Injury Severity Score: a more accurate predictor of in-hospital mortality than the Injury Severity Score
Centre Hospitalier Affilie Universitaire De Quebec, Enfant Jésus Hospital, Quebec City, Quebec, Canada
J Trauma 56:1312-20. 2004
- The association of sepsis syndrome and organ dysfunction with mortality in emergency department patients with suspected infection
Department of Emergency Medicine, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA 02215, USA
Ann Emerg Med 48:583-90, 590.e1. 2006