cause of death

Summary

Summary: Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint.

Top Publications

  1. doi Socioeconomic inequalities in health in 22 European countries
    Johan P Mackenbach
    Department of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands
    N Engl J Med 358:2468-81. 2008
  2. pmc Mortality in relation to smoking: 50 years' observations on male British doctors
    Richard Doll
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, Radcliffe Infirmary, Oxford OX2 6HE
    BMJ 328:1519. 2004
  3. ncbi Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data
    Alan D Lopez
    School of Population Health, University of Queensland, Brisbane 4006, Australia
    Lancet 367:1747-57. 2006
  4. ncbi 4 million neonatal deaths: when? Where? Why?
    Joy E Lawn
    Saving Newborn Lives Save the Children USA, and International Perinatal Care Unit, Institute of Child Health, London, Cape Town, South Africa
    Lancet 365:891-900. 2005
  5. ncbi Where and why are 10 million children dying every year?
    Robert E Black
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Lancet 361:2226-34. 2003
  6. pmc Counting the dead and what they died from: an assessment of the global status of cause of death data
    Colin D Mathers
    Evidence and Information for Policy, World Health Organization, Geneva, Switzerland
    Bull World Health Organ 83:171-7. 2005
  7. ncbi Cause-specific excess deaths associated with underweight, overweight, and obesity
    Katherine M Flegal
    National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD 20782, USA
    JAMA 298:2028-37. 2007
  8. doi Effect of a multifactorial intervention on mortality in type 2 diabetes
    Peter Gaede
    Steno Diabetes Center, Copenhagen, Denmark
    N Engl J Med 358:580-91. 2008
  9. doi A nationally representative case-control study of smoking and death in India
    Prabhat Jha
    Centre for Global Health Research, St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    N Engl J Med 358:1137-47. 2008
  10. ncbi Actual causes of death in the United States, 2000
    Ali H Mokdad
    Division of Adult and Community Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
    JAMA 291:1238-45. 2004

Detail Information

Publications326 found, 100 shown here

  1. doi Socioeconomic inequalities in health in 22 European countries
    Johan P Mackenbach
    Department of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands
    N Engl J Med 358:2468-81. 2008
    ..Comparisons among countries can help to identify opportunities for the reduction of inequalities in health. We compared the magnitude of inequalities in mortality and self-assessed health among 22 countries in all parts of Europe...
  2. pmc Mortality in relation to smoking: 50 years' observations on male British doctors
    Richard Doll
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, Radcliffe Infirmary, Oxford OX2 6HE
    BMJ 328:1519. 2004
    ..To compare the hazards of cigarette smoking in men who formed their habits at different periods, and the extent of the reduction in risk when cigarette smoking is stopped at different ages...
  3. ncbi Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data
    Alan D Lopez
    School of Population Health, University of Queensland, Brisbane 4006, Australia
    Lancet 367:1747-57. 2006
    ..Our aim was to calculate the global burden of disease and risk factors for 2001, to examine regional trends from 1990 to 2001, and to provide a starting point for the analysis of the Disease Control Priorities Project (DCPP)...
  4. ncbi 4 million neonatal deaths: when? Where? Why?
    Joy E Lawn
    Saving Newborn Lives Save the Children USA, and International Perinatal Care Unit, Institute of Child Health, London, Cape Town, South Africa
    Lancet 365:891-900. 2005
    ..Low birthweight is an important indirect cause of death. Maternal complications in labour carry a high risk of neonatal death, and poverty is strongly associated with ..
  5. ncbi Where and why are 10 million children dying every year?
    Robert E Black
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Lancet 361:2226-34. 2003
    ..A better understanding of child health epidemiology could contribute to more effective approaches to saving children's lives...
  6. pmc Counting the dead and what they died from: an assessment of the global status of cause of death data
    Colin D Mathers
    Evidence and Information for Policy, World Health Organization, Geneva, Switzerland
    Bull World Health Organ 83:171-7. 2005
    ..We sought to assess the current status of global data on death registration and to examine several indicators of data completeness and quality...
  7. ncbi Cause-specific excess deaths associated with underweight, overweight, and obesity
    Katherine M Flegal
    National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD 20782, USA
    JAMA 298:2028-37. 2007
    ..The association of body mass index (BMI) with cause-specific mortality has not been reported for the US population...
  8. doi Effect of a multifactorial intervention on mortality in type 2 diabetes
    Peter Gaede
    Steno Diabetes Center, Copenhagen, Denmark
    N Engl J Med 358:580-91. 2008
    ..We evaluated whether this approach would have an effect on the rates of death from any cause and from cardiovascular causes...
  9. doi A nationally representative case-control study of smoking and death in India
    Prabhat Jha
    Centre for Global Health Research, St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    N Engl J Med 358:1137-47. 2008
    ..The nationwide effects of smoking on mortality in India have not been assessed reliably...
  10. ncbi Actual causes of death in the United States, 2000
    Ali H Mokdad
    Division of Adult and Community Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
    JAMA 291:1238-45. 2004
    ..Modifiable behavioral risk factors are leading causes of mortality in the United States. Quantifying these will provide insight into the effects of recent trends and the implications of missed prevention opportunities...
  11. pmc Projections of global mortality and burden of disease from 2002 to 2030
    Colin D Mathers
    Evidence and Information for Policy Cluster, World Health Organization, Geneva, Switzerland
    PLoS Med 3:e442. 2006
    ..This paper describes the methods, assumptions, input data, and results...
  12. ncbi The validity of the diagnosis of acute myocardial infarction in routine statistics: a comparison of mortality and hospital discharge data with the Danish MONICA registry
    Mette Madsen
    National Institute of Public Health, Svanemøllevej 25, DK 2100 Copenhagen, Denmark
    J Clin Epidemiol 56:124-30. 2003
    ..For events with MI as the primary diagnosis or underlying cause of death the predictive value was 93.6% and sensitivity 77.6% when compared to DANMONICA definite or possible MI...
  13. pmc The global burden of injuries
    E G Krug
    World Health Organization, Geneva, Switzerland
    Am J Public Health 90:523-6. 2000
    ..Road traffic injuries are the 10th leading cause of death and the 9th leading cause of the burden of disease; self-inflicted injuries, falls, and interpersonal violence ..
  14. doi International study of temperature, heat and urban mortality: the 'ISOTHURM' project
    Anthony J McMichael
    National Centre for Epidemiology and Population Health, The Australian National University College of Medicine and Health Sciences, Canberra, Australia
    Int J Epidemiol 37:1121-31. 2008
    ..This study describes heat- and cold-related mortality in 12 urban populations in low- and middle-income countries, thereby extending knowledge of how diverse populations, in non-OECD countries, respond to temperature extremes...
  15. pmc Implications of mortality transition for primary health care in rural South Africa: a population-based surveillance study
    Stephen M Tollman
    MRC Wits Rural Public Health and Health Transitions Research Unit Agincourt, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa
    Lancet 372:893-901. 2008
    ..We investigated the extent and nature of this health transition and considered the implications for primary health care...
  16. ncbi Widening socioeconomic inequalities in mortality in six Western European countries
    Johan P Mackenbach
    Department of Public Health, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Int J Epidemiol 32:830-7. 2003
    ....
  17. pmc Population-level effect of HIV on adult mortality and early evidence of reversal after introduction of antiretroviral therapy in Malawi
    Andreas Jahn
    London School of Hygiene and Tropical Medicine, London, UK
    Lancet 371:1603-11. 2008
    ..We aimed to investigate mortality in a population before and after the introduction of free antiretroviral therapy, and therefore to assess the effects of such programmes on survival at the population level...
  18. ncbi Comparisons of causes of death and mortality rates among HIV-infected persons: analysis of the pre-, early, and late HAART (highly active antiretroviral therapy) eras
    Nancy F Crum
    Infectious Diseases Division, Clinical Investigation Department, Naval Medical Center San Diego, San Diego, CA 92134 1005, USA
    J Acquir Immune Defic Syndr 41:194-200. 2006
    ..Comparisons of death-related variables during the 3 eras were performed...
  19. ncbi Effects of cold weather on mortality: results from 15 European cities within the PHEWE project
    A Analitis
    Department of Hygiene, Epidemiology and Medical Statistics, Medical School, University of Athens, Athens, Greece
    Am J Epidemiol 168:1397-408. 2008
    ..Cold-related mortality is an important public health problem across Europe. It should not be underestimated by public health authorities because of the recent focus on heat-wave episodes...
  20. ncbi Autopsy causes of death in HIV-positive individuals in sub-Saharan Africa and correlation with clinical diagnoses
    Janneke A Cox
    Institute of Tropical Medicine, Antwerp, Belgium
    AIDS Rev 12:183-94. 2010
    ..Tuberculosis was the most frequent, present in 21-54% of HIV-positive adults and was considered the cause of death in 32-45%...
  21. pmc Exposing misclassified HIV/AIDS deaths in South Africa
    Jeanette Kurian Birnbaum
    Institute for Health Metrics and Evaluation, University of Washington, 2301 5th Avenue Suite 600, Seattle, WA 98121, United States of America
    Bull World Health Organ 89:278-85. 2011
    ..To quantify the deaths from human immunodeficiency virus (HIV) infection or acquired immunodeficiency syndrome (AIDS) that are misattributed to other causes in South Africa's death registration data and to adjust for this bias...
  22. ncbi Mortality displacement of heat-related deaths: a comparison of Delhi, São Paulo, and London
    Shakoor Hajat
    London School of Hygiene and Tropical Medicine, United Kingdom
    Epidemiology 16:613-20. 2005
    ..We compare the extent to which short-term mortality displacement can explain heat deaths in Delhi, São Paulo, and London given contrasting demographic and health profiles...
  23. ncbi Civil registration systems and vital statistics: successes and missed opportunities
    Prasanta Mahapatra
    Institute of Health Systems, Hyderabad, India
    Lancet 370:1653-63. 2007
    ..However, worldwide efforts to improve data have been limited to sporadic and short-term measures. We conclude that countries and developmental partners have not recognised that civil registration systems are a priority...
  24. ncbi Suicide rates in China, 1995-99
    Michael R Phillips
    Beijing Suicide Research and Prevention Center, Beijing Hui Long Guan Hospital, Beijing 100096, People s Republic of China
    Lancet 359:835-40. 2002
    ..We aimed to present an accurate picture of the current pattern of suicide in China on the basis of conservative estimates of suicide rates in different population cohorts...
  25. pmc Refining a probabilistic model for interpreting verbal autopsy data
    Peter Byass
    Umeå International School of Public Health, Umea University, Umea, Sweden
    Scand J Public Health 34:26-31. 2006
    To build on the previously reported development of a Bayesian probabilistic model for interpreting verbal autopsy (VA) data, attempting to improve the model's performance in determining cause of death and to reassess it.
  26. ncbi Mortality associated with influenza and respiratory syncytial virus in the United States
    William W Thompson
    Influenza Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    JAMA 289:179-86. 2003
    ..Influenza and respiratory syncytial virus (RSV) cause substantial morbidity and mortality. Statistical methods used to estimate deaths in the United States attributable to influenza have not accounted for RSV circulation...
  27. doi The Danish Register of Causes of Death
    Karin Helweg-Larsen
    National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark
    Scand J Public Health 39:26-9. 2011
    ..Cause-specific mortality statistics is a valuable source for the identification of risk factors for poor public health...
  28. pmc The impact of heat waves and cold spells on mortality rates in the Dutch population
    M M Huynen
    International Centre for Integrative Studies, Maastricht University, Maastricht, The Netherlands
    Environ Health Perspect 109:463-70. 2001
    ..The results concerning the forward displacement of deaths due to heat waves were not conclusive. We found no cold-induced forward displacement of deaths...
  29. ncbi Body-mass index and mortality in Korean men and women
    Sun Ha Jee
    Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea
    N Engl J Med 355:779-87. 2006
    ..Obesity is associated with diverse health risks, but the role of body weight as a risk factor for death remains controversial...
  30. ncbi Pulmonary function is a long-term predictor of mortality in the general population: 29-year follow-up of the Buffalo Health Study
    H J Schünemann
    Department of Social and Preventive Medicine, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, NY 14214 3000, USA
    Chest 118:656-64. 2000
    ..The purpose of this study was to investigate the predictive value of pulmonary function by gender after 29 years of follow-up...
  31. doi Stroke declines from third to fourth leading cause of death in the United States: historical perspective and challenges ahead
    Amytis Towfighi
    Division of Stroke and Critical Care, Department of Neurology, University of Southern California, Los Angeles, CA, USA
    Stroke 42:2351-5. 2011
    Stroke recently declined from the third to the fourth leading cause of death in the United States, its first rank transition among sources of American mortality in nearly 75 years.
  32. pmc High ambient temperature and mortality: a review of epidemiologic studies from 2001 to 2008
    Rupa Basu
    California Office of Environmental Hazard Assessment, Air Pollution Epidemiology Section, Oakland, California, USA
    Environ Health 8:40. 2009
    ..This review examines recent evidence on mortality from elevated ambient temperature for studies published from January 2001 to December 2008...
  33. ncbi WHO estimates of the causes of death in children
    Jennifer Bryce
    WHO, Geneva, Switzerland
    Lancet 365:1147-52. 2005
    ..Child survival efforts can be effective only if they are based on accurate information about causes of deaths. Here, we report on a 4-year effort by WHO to improve the accuracy of this information...
  34. ncbi Validity of verbal autopsy procedures for determining cause of death in Tanzania
    Philip W Setel
    Department of Epidemiology and MEASURE Evaluation, Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA
    Trop Med Int Health 11:681-96. 2006
    ..Verbal autopsy is an important method for deriving cause-specific mortality estimates where disease burdens are greatest and routine cause-specific mortality data do not exist...
  35. pmc Risk of all-cause mortality associated with nonfatal AIDS and serious non-AIDS events among adults infected with HIV
    Jacqueline Neuhaus
    University of Minnesota, Minneapolis, Minnesota, USA
    AIDS 24:697-706. 2010
    ....
  36. doi Low serum 25-hydroxyvitamin D levels are associated with increased all-cause mortality risk in a general population: the Tromsø study
    Moira Strand Hutchinson
    Department of Clinical Medicine, University of Tromsø, Tromsø, Norway
    Eur J Endocrinol 162:935-42. 2010
    ..Based on this, low serum 25(OH)D levels should be associated with higher all-cause mortality in a general population. This hypothesis was tested in the present study...
  37. ncbi Cardiovascular and noncardiovascular mortality among patients starting dialysis
    Dinanda J de Jager
    Department of Clinical Epidemiology, Leiden University Medical Center, C7 104, PO Box 9600, 2300 RC Leiden, The Netherlands
    JAMA 302:1782-9. 2009
    Cardiovascular mortality is considered the main cause of death in patients receiving dialysis and is 10 to 20 times higher in such patients than in the general population.
  38. pmc Causes of neonatal and child mortality in India: a nationally representative mortality survey
    Diego G Bassani
    Centre for Global Health Research, Li Ka Shing Knowledge Institute, St Michael s Hospital and Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5B 1W8, Canada
    Lancet 376:1853-60. 2010
    ..More than 2·3 million children died in India in 2005; however, the major causes of death have not been measured in the country. We investigated the causes of neonatal and child mortality in India and their differences by sex and region...
  39. ncbi Causes of death in hospitalized adults with a premortem diagnosis of tuberculosis: an autopsy study
    Neil A Martinson
    Johns Hopkins University Center for TB Research, Baltimore, Maryland, USA
    AIDS 21:2043-50. 2007
    ..To ascertain the immediate and underlying causes of death in adults who died in hospital with a premortem diagnosis of tuberculosis...
  40. ncbi Cancer survival in five continents: a worldwide population-based study (CONCORD)
    Michel P Coleman
    Cancer Research UK Cancer Survival Group, Non communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London, UK
    Lancet Oncol 9:730-56. 2008
    ..This is, to our knowledge, the first worldwide analysis of cancer survival, with standard quality-control procedures and identical analytic methods for all datasets...
  41. ncbi Initial burden of disease estimates for South Africa, 2000
    Debbie Bradshaw
    Burden of Disease Research Unit, Medical Research Council of South Africa, Tygerberg, W Cape
    S Afr Med J 93:682-8. 2003
    ..e. the years lived with disability (YLDs), are obtained to calculate disability-adjusted life years (DALYs); and the impact of AIDS on premature mortality in the year 2010 is assessed...
  42. ncbi Mortality due to systemic mycoses as a primary cause of death or in association with AIDS in Brazil: a review from 1996 to 2006
    Marli Prado
    Departamento de Epidemiologia, Escola de Saúde Pública, Universidade de Sao Paulo, Sao Paulo, SP, Brasil
    Mem Inst Oswaldo Cruz 104:513-21. 2009
    ..When analysed as the underlying cause of death, paracoccidioidomycosis represented the most important cause of deaths among systemic mycoses (approximately ..
  43. doi Prospective study of serum 25-hydroxyvitamin D level, cardiovascular disease mortality, and all-cause mortality in older U.S. adults
    Adit A Ginde
    Department of Emergency Medicine, School of Medicine, University of Colorado Denver, 12401 E 17th Avenue, B 215, Aurora, CO 80045
    J Am Geriatr Soc 57:1595-603. 2009
    ..To evaluate the association between serum 25-hydroxyvitamin D (25(OH)D) levels and mortality in a representative U.S. sample of older adults...
  44. pmc Heat-related and cold-related deaths in England and Wales: who is at risk?
    S Hajat
    Public and Environmental Health Research Unit, London School of Hygiene and Tropical Medicine, London, UK
    Occup Environ Med 64:93-100. 2007
    ..Despite the high burden from exposure to both hot and cold weather each year in England and Wales, there has been relatively little investigation on who is most at risk, resulting in uncertainties in informing government interventions...
  45. pmc Neonatal mortality, risk factors and causes: a prospective population-based cohort study in urban Pakistan
    Imtiaz Jehan
    Aga Khan University, Karachi, Pakistan
    Bull World Health Organ 87:130-8. 2009
    ..To evaluate the prevalence, sex distribution and causes of neonatal mortality, as well as its risk factors, in an urban Pakistani population with access to obstetric and neonatal care...
  46. ncbi Pathology and causes of death in a group of 128 predominantly HIV-positive patients in Botswana, 1997-1998
    N A Ansari
    The BOTUSA Project, Gaborone, Botswana
    Int J Tuberc Lung Dis 6:55-63. 2002
    ..Little is known about causes of death in countries of southern Africa seriously affected by the HIV/AIDS epidemic...
  47. ncbi Impact of the 2003 heatwave on all-cause mortality in 9 French cities
    Alain Le Tertre
    Environmental Health Department, Institut de Veille Sanitaire, Paris, France
    Epidemiology 17:75-9. 2006
    ..A heatwave occurred in France in August 2003, with an accompanying excess of all-cause mortality. This study quantifies this excess mortality and investigates a possible harvesting effect in the few weeks after the heatwave...
  48. ncbi Association of body mass index with suicide mortality: a prospective cohort study of more than one million men
    Patrik K E Magnusson
    Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Am J Epidemiol 163:1-8. 2006
    ..based on the Swedish Military Service Conscription Register, the Population and Housing Censuses, and the Cause of Death Register...
  49. pmc Causes of early mortality in HIV-infected TB suspects in an East African referral hospital
    Rachel Kyeyune
    Makerere University, Kampala, Uganda
    J Acquir Immune Defic Syndr 55:446-50. 2010
    Respiratory infections are a leading cause of death in Africa, especially among HIV-infected patients. Data on the etiology of fatal respiratory diseases are largely based on autopsy studies...
  50. doi The effect of early detection of occult brain metastases in HER2-positive breast cancer patients on survival and cause of death
    Anna Niwinska
    Department of Breast Cancer and Reconstructive Surgery, Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
    Int J Radiat Oncol Biol Phys 77:1134-9. 2010
    ..is to evaluate disease-free survival, survival from the detection of brain metastases, overall survival, and cause of death in patients with occult brain metastases (Group I) vs. patients with symptomatic brain metastases (Group II).
  51. pmc A 10 year study of the cause of death in children under 15 years in Manhiça, Mozambique
    Jahit Sacarlal
    Centro de Investigação em Saúde da Manhiça CISM, Mozambique
    BMC Public Health 9:67. 2009
    ....
  52. pmc No cry at birth: global estimates of intrapartum stillbirths and intrapartum-related neonatal deaths
    Joy Lawn
    Saving Newborn Lives Save the Children, International Perinatal Care Unit, Institute of Child Health, London, England
    Bull World Health Organ 83:409-17. 2005
    ..7 to 1.2 million. Estimates for intrapartum stillbirths are not available. We aimed to estimate the numbers of intrapartum-related neonatal deaths and intrapartum stillbirths in the year 2000...
  53. ncbi The Danish registers of causes of death
    K Juel
    Danish Institute for Clinical Epidemiology, Copenhagen
    Dan Med Bull 46:354-7. 1999
    ..This paper describes the history of the registers, the data sources and access to data, and the research based upon the registers, presenting some examples of research activities...
  54. ncbi Validation and application of verbal autopsies in a rural area of South Africa
    K Kahn
    Health Systems Development Unit, Department of Community Health, University of the Witwatersrand, Johannesburg, South Africa
    Trop Med Int Health 5:824-31. 2000
    ..To validate the causes of death determined with a single verbal autopsy instrument covering all age groups in the Agincourt subdistrict of rural South Africa...
  55. ncbi Contribution of major diseases to disparities in mortality
    Mitchell D Wong
    Division of General Internal Medicine and Health Services Research, University of California at Los Angeles, Los Angeles 90095 1736, USA
    N Engl J Med 347:1585-92. 2002
    ..Mortality from all causes is higher for persons with fewer years of education and for blacks, but it is unknown which diseases contribute most to these disparities...
  56. pmc Are there differences in all-cause and coronary heart disease mortality between immigrants in Sweden and in their country of birth? A follow-up study of total populations
    Malin Gadd
    CeFAM Center for Family and Community Medicine, Neurotec, Karolinska Institutet, Stockholm, Sweden
    BMC Public Health 6:102. 2006
    ..The purpose of the present study was to analyse whether all-cause and coronary heart disease mortality differ between immigrants in Sweden and in the country of birth...
  57. ncbi Increased cause-specific mortality associated with 2003 heat wave in Essen, Germany
    Barbara Hoffmann
    Institute for Medical Informatics, Biometry and Epidemiology, University Hospital, University of Duisburg Essen, Essen, Germany
    J Toxicol Environ Health A 71:759-65. 2008
    ..Different mechanisms appear to influence cause-specific mortality, with strongest associations for respiratory mortality. Harvesting might play a role in mortality due to neoplasms...
  58. pmc Evaluating the InterVA model for determining AIDS mortality from verbal autopsies in the adult population of Addis Ababa
    Biruk Tensou
    Addis Ababa Mortality Surveillance Project, Faculty of Medicine, Addis Ababa University, Addis Ababa, Ethiopia
    Trop Med Int Health 15:547-53. 2010
    ..To evaluate the performance of a verbal autopsy (VA) expert algorithm (the InterVA model) for diagnosing AIDS mortality against a reference standard from hospital records that include HIV serostatus information in Addis Ababa, Ethiopia...
  59. ncbi Post-mortem findings in harbour porpoises (Phocoena phocoena) from the German North and Baltic Seas
    U Siebert
    , , Frankfurter Strasse 96, 35392 Giessen, Germany
    J Comp Pathol 124:102-14. 2001
    ..Pneumonia was considered to be the cause of death in 46% of the stranded subadult and adult animals...
  60. ncbi Methodology of studies evaluating death certificate accuracy were flawed
    Lars Age Johansson
    Centre for Epidemiology, Swedish National Board of Health and Welfare, SE 106 30 Stockholm, Sweden
    J Clin Epidemiol 59:125-31. 2006
    ..Statistics on causes of death are important for epidemiologic research. Studies that evaluate the source data often give conflicting results, which raise questions about comparability and validity of methods...
  61. ncbi Worldwide mortality in men and women aged 15-59 years from 1970 to 2010: a systematic analysis
    JULIE KNOLL RAJARATNAM
    Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA 98121, USA
    Lancet 375:1704-20. 2010
    ..However, adult mortality has received little policy attention, resources, or monitoring efforts. This study aimed to estimate worldwide mortality in men and women aged 15-59 years...
  62. pmc What you count is what you target: the implications of maternal death classification for tracking progress towards reducing maternal mortality in developing countries
    Suzanne Cross
    Immpact, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, Scotland
    Bull World Health Organ 88:147-53. 2010
    ..It is recommended that the potential effect of maternity services failing to take indirect maternal deaths into account should be modelled...
  63. ncbi Mortality and causes of death in adults receiving highly active antiretroviral therapy in Senegal: a 7-year cohort study
    Jean Francois Etard
    UMR 145 HIV AIDS and Associated Diseases, Research Institute for Development IRD University of Montpellier, 911 Avenue Agropolis, 34394 Montpellier Cedex 1, France
    AIDS 20:1181-9. 2006
    ..To evaluate survival and investigate causes of death among HIV-1 infected adults receiving HAART in Senegal...
  64. pmc The global burden of disease in 1990: summary results, sensitivity analysis and future directions
    C J Murray
    Harvard Centre for Population and Development Studies, Cambridge MA 02138
    Bull World Health Organ 72:495-509. 1994
    ..The paper also shows how the estimates depend on particular values of the parameters involved in the calculation...
  65. ncbi Long-term mortality in a nationwide cohort of childhood-onset type 1 diabetic patients in Norway
    T Skrivarhaug
    Department of Pediatrics, Ulleval University Hospital, N 0407 Oslo, Norway
    Diabetologia 49:298-305. 2006
    ..We examined long-term total and cause-specific mortality in a nationwide, population-based Norwegian cohort of patients with childhood-onset type 1 diabetes...
  66. ncbi Effect of age and comorbidity in postmenopausal breast cancer patients aged 55 years and older
    R Yancik
    Cancer Section, Geriatrics Program, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892 9205, USA
    JAMA 285:885-92. 2001
    ..Postmenopausal women aged 55 years and older have 66% of incident breast tumors and experience 77% of breast cancer mortality, but other age-related health problems may affect tumor prognosis and treatment decisions...
  67. ncbi Causes of death among persons with AIDS in the era of highly active antiretroviral therapy: New York City
    Judith E Sackoff
    HIV Epidemiology Program, Bureau of HIV AIDS Prevention and Control, New York City Department of Health and Mental Hygiene, New York, New York 10013, USA
    Ann Intern Med 145:397-406. 2006
    ..Monitoring the full spectrum of causes of death among persons with AIDS is increasingly important as survival improves because of highly active antiretroviral therapy...
  68. ncbi Causes of death among human immunodeficiency virus (HIV)-infected adults in the era of potent antiretroviral therapy: emerging role of hepatitis and cancers, persistent role of AIDS
    Charlotte Lewden
    INSERM U593 exU330, 146 rue Leo Saignat, 33076 Bordeaux Cedex, France
    Int J Epidemiol 34:121-30. 2005
    ..The Mortality 2000 study examined the causes of death in HIV-infected adults at a national level in France in the year 2000...
  69. doi Cause of death and presence of respiratory disease at autopsy in an HIV-1 seroconversion cohort of southern African gold miners
    Jill Murray
    National Institute for Occupational Health, PO Box 4788, Johannesburg2000, South Africa
    AIDS 21:S97-S104. 2007
    ..To describe causes of death and respiratory infections in HIV-infected miners in the pre-antiretroviral era, by duration of HIV infection...
  70. pmc Setting international standards for verbal autopsy
    Frank Baiden
    Bull World Health Organ 85:570-1. 2007
  71. doi Effect of misclassified underlying cause of death on survival estimates of colon and rectal cancer
    Daixin Yin
    California Cancer Registry, Public Health Institute, Sacramento, CA 95825, USA
    J Natl Cancer Inst 103:1130-3. 2011
    Inaccurate coding of patients' Underlying Cause of Death (UCOD) has constrained cause-specific survival estimates for colon and rectal cancers...
  72. doi Duchenne muscular dystrophy: continuous noninvasive ventilatory support prolongs survival
    John R Bach
    Department of Physical Medicine and Rehabilitation, University Hospital, New Jersey Medical School, Newark, New Jersey 07103, USA
    Respir Care 56:744-50. 2011
    ..To describe survival outcomes with noninvasive ventilation (NIV) for full ventilatory support, and a mechanically assisted cough and oximetry protocol in a series of patients with Duchenne muscular dystrophy...
  73. ncbi Burden, differentials, and causes of child deaths in India
    Chandrakant Lahariya
    Department of Community Medicine, G R Medical College, Gwalior, India
    Indian J Pediatr 77:1312-21. 2010
    ..To review the current information on trends, burden, differentials, causes, and timing of under five (U5) child deaths in India...
  74. doi Mortality in north american dogs from 1984 to 2004: an investigation into age-, size-, and breed-related causes of death
    J M Fleming
    Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA, USA
    J Vet Intern Med 25:187-98. 2011
    ..Detailed knowledge of mortality patterns would facilitate development of tailored health-maintenance practices and contribute to the understanding of the genetic basis of disease...
  75. ncbi Where the elderly die: the influence of socio-demographic factors and cause of death on people dying at home
    Arthur K L Beng
    Healthcare Finance and Corporate Services Division, Ministry of Health, Singapore c net sg
    Ann Acad Med Singapore 38:676-83. 2009
    ..The aim of this study is to describe where deaths of elderly occur in Singapore and to determine the association of socio-demographic characteristics and the causes of death on dying at home...
  76. doi Valproate attenuates the risk of myocardial infarction in patients with epilepsy: a nationwide cohort study
    Jonas Bjerring Olesen
    Department of Cardiology, Gentofte University Hospital, Hellerup, Denmark
    Pharmacoepidemiol Drug Saf 20:146-53. 2011
    ..Patients with epilepsy have increased risk of myocardial infarction (MI). Valproate can exert anti-atherosclerotic effects. We therefore examined the risk of MI in patients with epilepsy receiving valproate...
  77. doi Impact of socioeconomic, behavioral and clinical risk factors on mortality
    Kimberly Rask
    Rollins School of Public Health, Health Policy and Management, 1518 Clifton Road, Rm 636, Atlanta, GA 30322, USA
    J Public Health (Oxf) 31:231-8. 2009
    ..Efforts to reduce mortality will require a multi-faceted approach incorporating healthy behaviors and accessible health care systems in addition to clinical advances...
  78. doi Marital status, educational level and household income explain part of the excess mortality of survey non-respondents
    Hanna Tolonen
    National Institute for Health and Welfare, Helsinki, Finland
    Eur J Epidemiol 25:69-76. 2010
    ..the 1978 to 2002 surveys, including non-respondents, were linked with mortality data from the Finnish National Cause of Death statistics and with demographic and socio-economic register data (marital status, education and household ..
  79. ncbi Procedural and 30-day outcomes following transcatheter aortic valve implantation using the third generation (18 Fr) corevalve revalving system: results from the multicentre, expanded evaluation registry 1-year following CE mark approval
    Nicolo Piazza
    Thoraxcenter, Rotterdam, The Netherlands
    EuroIntervention 4:242-9. 2008
    ..To describe the procedural performance and 30-day outcomes following implantation using the 18 Fr CoreValve Revalving System (CRS) as part of the multicentre, expanded evaluation registry, 1-year after obtaining CE mark approval...
  80. ncbi Mortality differences according to living arrangements
    Seppo Koskinen
    National Public Health Institute, Department of Health and Functional Capacity, Helsinki, Finland
    Int J Epidemiol 36:1255-64. 2007
    ....
  81. pmc Cause-specific mortality and the extended effects of particulate pollution and temperature exposure
    Patrick G Goodman
    School of Physics, Dublin Institute of Technology, and St James Hospital, Dublin, Ireland
    Environ Health Perspect 112:179-85. 2004
    ..This analysis suggests that studies on the acute effects of air pollution have underestimated the total effects of temperature and particulate air pollution on mortality...
  82. ncbi Clinical risk factors for mortality in patients with neurofibromatosis 1: a cohort study of 378 patients
    Kiarash Khosrotehrani
    Department of Dermatology, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris, Creteil, France
    Arch Dermatol 139:187-91. 2003
    ..To identify the main clinical features associated with mortality in patients with neurofibromatosis 1...
  83. ncbi Mortality among patients admitted to hospitals on weekends as compared with weekdays
    C M Bell
    Department of Medicine, University of Toronto, Sunnybrook and Women's College Health Sciences Centre, ON, Canada
    N Engl J Med 345:663-8. 2001
    ..CONCLUSIONS: Patients with some serious medical conditions are more likely to die in the hospital if they are admitted on a weekend than if they are admitted on a weekday...
  84. pmc Inflammatory and coagulation biomarkers and mortality in patients with HIV infection
    Lewis H Kuller
    University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    PLoS Med 5:e203. 2008
    ..We hypothesized that increased HIV-RNA levels following ART interruption induced activation of tissue factor pathways, thrombosis, and fibrinolysis...
  85. ncbi Causes of deaths in children younger than 5 years in China in 2008
    Igor Rudan
    Centre for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, UK
    Lancet 375:1083-9. 2010
    ..We identified the main causes of deaths in neonates (<1 month), postneonatal infants (1-11 months), and children (<5 years) in China using information that was available to the public...
  86. doi Body mass index and mortality: results of a cohort of 184,697 adults in Austria
    Jochen Klenk
    Institute of Epidemiology, University of Ulm, Helmholtzstrasse 22, 89081 Ulm, Germany
    Eur J Epidemiol 24:83-91. 2009
    ..Respiratory diseases contributed to mortality in the lowest BMI category independently from smoking status. Underweight and obesity were both associated with higher all-cause mortality in men and women...
  87. doi Newborn survival in low resource settings--are we delivering?
    J E Lawn
    Saving Newborn Lives Save the Children USA, Cape Town 7405, South Africa
    BJOG 116:49-59. 2009
    ..There are promising models that have been tested mainly in research studies in Asia that are now being adapted and evaluated at scale including through a network of African implementation research trials...
  88. ncbi Estimates of global mortality attributable to smoking in 2000
    Majid Ezzati
    Department of Population and International Health, Harvard School of Public Health, Boston, MA 02115, USA
    Lancet 362:847-52. 2003
    ..Smoking is a risk factor for several diseases and has been increasing in many developing countries. Our aim was to estimate global and regional mortality in 2000 caused by smoking, including an analysis of uncertainty...
  89. doi The Accelerated Child Survival and Development programme in west Africa: a retrospective evaluation
    Jennifer Bryce
    Institute for International Programs, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Lancet 375:572-82. 2010
    ..We undertook a retrospective evaluation of the programme in Benin, Ghana, and Mali...
  90. ncbi Changing mortality rates and causes of death for HIV-infected individuals living in Southern Alberta, Canada from 1984 to 2003
    H B Krentz
    Southern Alberta Clinic, Calgary, Alberta, Canada
    HIV Med 6:99-106. 2005
    ..To examine changes over a 2-year period in both the mortality rate and the causes of death in a geographically defined HIV-infected population...
  91. ncbi Evaluation of neonatal verbal autopsy using physician review versus algorithm-based cause-of-death assignment in rural Nepal
    James V Freeman
    Department of Internal Medicine, Stanford University Medical Center, Stanford, CA, USA
    Paediatr Perinat Epidemiol 19:323-31. 2005
    ..We recommend an analysis technique that combines both methods, and further validation studies to improve performance of the VA for assigning causes of neonatal death...
  92. pmc Diseases of comfort: primary cause of death in the 22nd century
    Bernard C K Choi
    Centre for Chronic Disease Prevention and Control CCDPC, Public Health Agency of Canada PHAC, Government of Canada, AL no 6701A, 120 Colonnade Road, Ottawa, Ontario K1A 1B4, Canada
    J Epidemiol Community Health 59:1030-4. 2005
    ..If uncurbed, a new generation of "diseases of comfort" (such as those chronic diseases caused by obesity and physical inactivity) will become a major public health problem in this and the next century...
  93. ncbi Validity of verbal autopsy in determining causes of adult deaths
    R Kumar
    Department of Community Medicine, PGIMER, Chandigarh
    Indian J Public Health 50:90-4. 2006
    ..The sensitivity and specificity of the cause of death assigned by physician from the verbal autopsy was calculated against the cause of death derived from the ..
  94. ncbi Aetiology of stillbirths and neonatal deaths in rural Ghana: implications for health programming in developing countries
    Karen M Edmond
    Kintampo Health Research Centre, Ghana Health Service, Kintampo, Brong Ahafo Region, Ghana
    Paediatr Perinat Epidemiol 22:430-7. 2008
    In developing countries many stillbirths and neonatal deaths occur at home and cause of death is not recorded by national health information systems...
  95. pmc Ecological association between a deprivation index and mortality in France over the period 1997 - 2001: variations with spatial scale, degree of urbanicity, age, gender and cause of death
    Grégoire Rey
    INSERM, CépiDc, IFR69, Le Vesinet, France
    BMC Public Health 9:33. 2009
    ..More specifically, the variations with the degree of urbanicity, spatial scale, age, gender and cause of death, which influence the association between mortality and deprivation, have been described.
  96. pmc Validation of the symptom pattern method for analyzing verbal autopsy data
    Christopher J L Murray
    Institute for Health Metrics and Evaluation, University of Washington, Seattle, Washington, United States of America
    PLoS Med 4:e327. 2007
    b>Cause of death data are a critical input to formulating good public health policy...
  97. doi Guidelines for reporting mortality and morbidity after cardiac valve interventions
    Cary W Akins
    The American Association for Thoracic Surgery, Beverly, Massachusetts, USA
    Ann Thorac Surg 85:1490-5. 2008
  98. doi Mortality and cause of death in mucopolysaccharidosis type II-a historical review based on data from the Hunter Outcome Survey (HOS)
    S A Jones
    Willink Unit, Genetic Medicine, Manchester Academic Health Science Centre, Central Manchester University Hospitals, NHS Foundation Trust, St Mary s Hospital, Manchester, UK
    J Inherit Metab Dis 32:534-43. 2009
    ..Data from patients who died after 1985 could serve as a control in analyses of the effects of enzyme replacement therapy with idursulfase on mortality in patients with MPS II...
  99. ncbi The impact of marital status on cancer survival
    O Kravdal
    Department of Economics and Norwegian Cancer Registry, University of Oslo
    Soc Sci Med 52:357-68. 2001
    ..Other previously married have an excess mortality elevated by about 7%. This protective effect of marriage is not due to stage, which is controlled for. The possible importance of treatment and host factors is discussed...
  100. doi Tissue inhibitor of metalloproteinases levels in patients with chronic heart failure: an independent predictor of mortality
    S Frantz
    Department of Internal Medicine I, Center of Cardiovascular Medicine, University of Wurzburg, Wurzburg, Germany
    Eur J Heart Fail 10:388-95. 2008
    ..Matrix metalloproteinases (MMP) and their tissue inhibitors (TIMP) are involved in cardiac remodelling. The prognostic utility of TIMP is unknown in chronic heart failure (CHF)...
  101. ncbi Obesity and survival in patients with heart failure and preserved systolic function: a U-shaped relationship
    John R Kapoor
    Division of Cardiology, Stanford University, Palo Alto, CA 94305, USA
    Am Heart J 159:75-80. 2010
    ..However, it is unknown if this "obesity paradox" applies to heart failure patients with preserved EF or if it extends to the very obese (BMI >35)...

Research Grants90

  1. Age at Marriage, Women's Education, and Mother and Child Outcomes in Bangladesh
    Erica M Field; Fiscal Year: 2011
    ..at a young age (Jensen and Thornton, 2003), and complicafions in pregnancy and delivery are a leading cause of death among giris aged 15 to 19. Maternal mortality in this group is double the rates for women in their 20s...
  2. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2010
    ..and underpin the programs to be implemented under this new project Infections are the second most common cause of death in thalassemia major...
  3. Prevention of Complications in Thalassemia
    Elliott Vichinsky; Fiscal Year: 2009
    ..and underpin the programs to be implemented under this new project Infections are the second most common cause of death in thalassemia major...
  4. Prevention of Complications in Thalassemia
    Elliott Vichinsky; Fiscal Year: 2007
    ..and underpin the programs to be implemented under this new project: Infections are the second most common cause of death in thalassemia major...
  5. Intracavitary Hemostatic Agent for Non-compressible Hemorrhage
    Maja Nowakowski; Fiscal Year: 2010
    Hemorrhage resulting from traumatic injuries is a major cause of death in accidents, and the primary cause of death on the battlefield. Over 40% of the trauma cases admitted at hospitals in the USA, are due to road traffic accidents...
  6. Intracavitary Hemostatic Agent for Non-compressible Hemorrhage
    Maja Nowakowski; Fiscal Year: 2009
    Hemorrhage resulting from traumatic injuries is a major cause of death in accidents, and the primary cause of death on the battlefield. Over 40% of the trauma cases admitted at hospitals in the USA, are due to road traffic accidents...
  7. Intracavitary Hemostatic Agent for Non-compressible Hemorrhage
    Maja Nowakowski; Fiscal Year: 2010
    Hemorrhage resulting from traumatic injuries is a major cause of death in accidents, and the primary cause of death on the battlefield. Over 40% of the trauma cases admitted at hospitals in the USA, are due to road traffic accidents...
  8. Prevention of Acute Lung Injury by IL-6 activated STAT3
    Ana Moran; Fiscal Year: 2010
    Trauma is accompanied frequently by hemorrhagic shock and is the leading cause of death for those under 45 years old in the United States...
  9. Intracavitary Hemostatic Agent for Non-compressible Hemorrhage
    Martin Bluth; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Hemorrhage resulting from traumatic injuries is a major cause of death in accidents, and the primary cause of death on the battlefield...
  10. Use of Beta-Lapachone for Lung Cancer Chemotherapy
    David Boothman; Fiscal Year: 2007
    Use of B-lapachone for non-small cell lung cancer (NSCLC) therapy Lung cancer is the leading cause of death by cancer in the U.S. Non-small cell lung cancer (NSCLC) comprises over 75% of lung cancers diagnosed...
  11. Use of Beta-Lapachone for Lung Cancer Chemotherapy
    David Boothman; Fiscal Year: 2007
    Use of B-lapachone for non-small cell lung cancer (NSCLC) therapy Lung cancer is the leading cause of death by cancer in the U.S. Non-small cell lung cancer (NSCLC) comprises over 75% of lung cancers diagnosed...
  12. Intrathoracic Pressure Regulation for the Treatment of Septic Shock
    Keith Lurie; Fiscal Year: 2009
    Despite advances in the treatment of patients with sepsis, sepsis remains the second most common cause of death in non-coronary intensive care units and the tenth leading cause of death overall in high-income countries...
  13. Development and Validation of a Diagnostic Tool for Infant Head Injuries from Fal
    Susan Margulies; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): PROJECT ABSTRACT/SUMMARY Traumatic brain injury (TBI) is the most common cause of death in childhood...
  14. OLDER BREAST CANCER PATIENTS: RISK FOR COGNITIVE DECLINE
    Jeanne Mandelblatt; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: Cancer is the leading cause of death in the US and breast cancer is the second most common cancer among women in our country...
  15. Novel non-invasive device for treatment of elevated intracranial pressures
    Keith G Lurie; Fiscal Year: 2010
    ..Despite advances in the treatment of patients with head injuries, traumatic brain injury is the leading cause of death and disability in children, adults in their most productive years, and our soldiers in the military...
  16. MECHANISMS AND TREATMENT OF COPD PROGRESSION
    Robert Wise; Fiscal Year: 2007
    ..Obstructive Pulmonary Disease (COPD) is a disabling disorder that affects millions of people and is a leading cause of death in the U.S. and worldwide...
  17. MECHANISMS AND TREATMENT OF COPD PROGRESSION
    Robert Wise; Fiscal Year: 2009
    ..Obstructive Pulmonary Disease (COPD) is a disabling disorder that affects millions of people and is a leading cause of death in the U.S. and worldwide...
  18. The mechanisms by which alcohol and HIV render the lung susceptible to injury
    DAVID MARSHALL GUIDOT; Fiscal Year: 2011
    ..This research project is designed to determine how alcohol and HIV-1 interact to make the lung susceptible to injury, and to develop effective treatments that can improve the health of these vulnerable individuals. ..
  19. Older Mothers and Adult Daughters: High Blood Pressure Self Management Behaviors
    Celeste Shawler; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Heart disease is the leading cause of death in American women. Kentucky ranks as the 6 highest state in the nation for heart disease among women...
  20. Chicago Community-Acquired Pneumonia Consortium
    Richard Wunderink; Fiscal Year: 2009
    ..Community-acquired pneumonia, often complicating influenza or other viral infections, remains an important cause of death in the US...
  21. Mechanisms of Programmed Gestational Hyperphagia
    Michael Ross; Fiscal Year: 2009
    ..Obesity and its related diseases are the leading cause of death in western society, with associated risks of hypertension, coronary heart disease, stroke, diabetes, and ..
  22. Mechanisms of Programmed Gestational Hyperphagia
    MICHAEL GLENN ROSS; Fiscal Year: 2010
    ..Obesity and its related diseases are the leading cause of death in western society, with associated risks of hypertension, coronary heart disease, stroke, diabetes, and ..
  23. Development and Validation of an Instrument to Assess Cognitive Function Regulati
    Xi Chen; Fiscal Year: 2012
    ....
  24. Research Study to Assess the Risk of Blood Borne Transmission of Creutzfeldt-Jako
    Shimian Zou; Fiscal Year: 2009
    ..and/or transfusion centers identify the recipients and report the survival status and if deceased the date and cause of death of that recipient...
  25. Research Study to Assess the Risk of Blood Borne Transmission of Creutzfeldt-Jako
    Shimian Zou; Fiscal Year: 2010
    ..and/or transfusion centers identify the recipients and report the survival status and if deceased the date and cause of death of that recipient...
  26. Inhibition of HCV as an Opportunistic HIV Co-infection
    James C Fishbein; Fiscal Year: 2010
    ..In a recent study exploring the cause of death in HIV patients, a majority of the dead had tested positive for antibodies to HCV...
  27. Inhibition of HCV as an Opportunistic HIV Co-infection
    RAMACHANDRA HOSMANE; Fiscal Year: 2009
    ..In a recent study exploring the cause of death in HIV patients, a majority of the dead had tested positive for antibodies to HCV...
  28. Epidemiology and Etiology of Hospitalized Pneumonia in Children
    Krow Ampofo; Fiscal Year: 2010
    Pneumonia in children is a major cause of morbidity and mortality worldwide and the leading cause of death in children younger than 5 years of age worldwide...
  29. Epidemiology and Etiology of Hospitalized Pneumonia in Children
    Krow Ampofo; Fiscal Year: 2010
    Pneumonia in children is a major cause of morbidity and mortality worldwide and the leading cause of death in children younger than 5 years of age worldwide...
  30. Epidemiology and Etiology of Hospitalized Pneumonia in Children
    Krow Ampofo; Fiscal Year: 2009
    Pneumonia in children is a major cause of morbidity and mortality worldwide and the leading cause of death in children younger than 5 years of age worldwide...
  31. Role of Lipid Phosphatases in Cholesterol and Triglyceride Synthesis
    Andrew Morris; Fiscal Year: 2009
    ....
  32. Role of Lipid Phosphatases in Cholesterol and Triglyceride Synthesis
    Andrew J Morris; Fiscal Year: 2010
    ....
  33. Role of Lipid Phosphatases in Cholesterol and Triglyceride Synthesis
    Andrew J Morris; Fiscal Year: 2010
    ....
  34. Drug-Eluting Bioresorbable Polymer Scaffolding for Treatment of Aortic Aneurysms
    Jack Griffis; Fiscal Year: 2009
    ..Aortic aneurysms affect as many as eight percent of people over the age of 65 and remains the 13th leading cause of death in the United States, accounting for more than 15,000 deaths each year...
  35. Therapeutic use of small-molecule HGF-mimetic for emphysema
    Bert Oehlen; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Emphysema is a major cause of death and disability and afflicts approximately 2 million people. The disease cost more than $2...
  36. Therapeutic use of small-molecule HGF-mimetic for emphysema
    BERT J W M OEHLEN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Emphysema is a major cause of death and disability and afflicts approximately 2 million people. The disease cost more than $2...
  37. Overcoming Membrane Transporters to Improve CNS Drug Therapy
    Robert Clark; Fiscal Year: 2009
    ..Notably, traumatic brain injury (TBI) remains the leading cause of death and disability amongst children and young adults...
  38. Micro-patterned surfaces for reducing the risk of catheter-associated UTI
    SHRAVANTHI REDDY; Fiscal Year: 2009
    ..Nosocomial infections are a leading cause of death in the U.S., and they result in major increases in hospital stays, human suffering, and healthcare costs...
  39. Inhibitors of the ENT4 Adenosine Transporter for Cardioprotection
    John Buolamwini; Fiscal Year: 2009
    ..provided by applicant): The advances in treatment notwithstanding, heart disease remains the number one cause of death in the Nation, claiming the lives of nearly one million Americans each year, and running up medical costs ..
  40. Self-Sensing Physiologic Control of a Rotary Mag Lev LVAD
    JAMES FARLEY WALTON; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Heart failure is the number one cause of death in the United States and presents an increasing public burden of morbidity and mortality even as the mortality from coronary artery disease and ..
  41. Self-Sensing Physiologic Control of a Rotary Mag Lev LVAD
    James Walton; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Heart failure is the number one cause of death in the United States and presents an increasing public burden of morbidity and mortality even as the mortality from coronary artery disease and ..
  42. Bioactive Peptides for Mitigation of AGS and Acute Radiation Injury
    Lurong Zhang; Fiscal Year: 2010
    ..It would also reduce the overwhelming economic burden on health care system due to use the cheap and stable bioactive peptides rather than the expensive native proteins of growth factors. ..
  43. GM-CSF-Adjuvanted Clade C DNA/MVA and MVA/MVA Vaccines
    Harriet Robinson; Fiscal Year: 2009
    ..provided by applicant): The acquired immunodeficiency syndrome (AIDS) caused by HIV-1 is the leading cause of death in Africa and the fourth leading cause of death worldwide...
  44. GM-CSF-Adjuvanted Clade C DNA/MVA and MVA/MVA Vaccines
    Harriet Robinson; Fiscal Year: 2007
    The acquired immunodeficiency syndrome (AIDS) caused by HIV-1 is the leading cause of death in Africa and the fourth leading cause of death worldwide...
  45. Molecular Biology of Hemorrhagic Schock
    Timothy Billiar; Fiscal Year: 2007
    Trauma is the leading cause of death in this country in people under the age of 54 years...
  46. Molecular Biology of Hemorrhagic Schock
    Timothy Billiar; Fiscal Year: 2006
    Trauma is the leading cause of death in this country in people under the age of 54 years...
  47. Molecular Biology of Hemorrhagic Schock
    Timothy Billiar; Fiscal Year: 2005
    Trauma is the leading cause of death in this country in people under the age of 54 years...
  48. Stroke Disparities Program
    Chelsea Kidwell; Fiscal Year: 2009
    DESCRIPTION (abstract): Acute stroke is the third leading cause of death and the leading cause of adult disability in the US. A disproportionate amount of morbidity and mortality falls on underserved populations...
  49. Molecular Biology of Hemorrhagic Schock
    Timothy Billiar; Fiscal Year: 2004
    Trauma is the leading cause of death in this country in people under the age of 54 years...
  50. Stroke Disparities Program
    Chelsea Kidwell; Fiscal Year: 2007
    DESCRIPTION (abstract): Acute stroke is the third leading cause of death and the leading cause of adult disability in the US. A disproportionate amount of morbidity and mortality falls on underserved populations...
  51. Stroke Disparities Program
    Chelsea Kidwell; Fiscal Year: 2009
    DESCRIPTION (abstract): Acute stroke is the third leading cause of death and the leading cause of adult disability in the US. A disproportionate amount of morbidity and mortality falls on underserved populations...
  52. Biomarkers of toxic response to low nicotine cigarette smoke
    Andrew Strasser; Fiscal Year: 2010
    ..Exposure to tobacco smoke (mainstream and environmental) is a leading cause of death in the US...
  53. Biomarkers of toxic response to low nicotine cigarette smoke
    Ian Blair; Fiscal Year: 2009
    ..Exposure to tobacco smoke (mainstream and environmental) is a leading cause of death in the US...
  54. Improved Drug Delivery to Tumors Using Novel Tissue Perfusion Approaches
    Lisa Coussens; Fiscal Year: 2009
    DESCRIPTION: Breast cancer is the most common cancer and second leading cause of death in women...
  55. Epidemiology, Prevention and Treatment of Influenza and Other Respiratory Infecti
    William Kwabena Ampofo; Fiscal Year: 2012
    ..infections (ALRI) are a common cause of illness globally and it is estimated to be the third common cause of death, approximately 7% of all deaths in 2004...
  56. Cardiopulmonary structure and function in Multi-Ethnic Study of Atherosclerosis
    R Graham Barr; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States. COPD will overtake stroke as the third leading cause of death within 7 years...
  57. DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISK
    ERNST SCHAEFER; Fiscal Year: 2000
    Coronary heart disease (CHD) is a major cause of death and disability in our society. Obesity increases CHD risk by adversely affecting glucose, lipoproteins, and blood pressure...
  58. DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISK
    ERNST SCHAEFER; Fiscal Year: 1999
    Coronary heart disease (CHD) is a major cause of death and disability in our society. Obesity increases CHD risk by adversely affecting glucose, lipoproteins, and blood pressure...
  59. DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISK
    ERNST SCHAEFER; Fiscal Year: 2003
    Coronary heart disease (CHD) is a major cause of death and disability in our society. Obesity increases CHD risk by adversely affecting glucose, lipoproteins, and blood pressure...
  60. DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISK
    ERNST SCHAEFER; Fiscal Year: 2002
    Coronary heart disease (CHD) is a major cause of death and disability in our society. Obesity increases CHD risk by adversely affecting glucose, lipoproteins, and blood pressure...
  61. DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISK
    ERNST SCHAEFER; Fiscal Year: 2001
    Coronary heart disease (CHD) is a major cause of death and disability in our society. Obesity increases CHD risk by adversely affecting glucose, lipoproteins, and blood pressure...
  62. Pharmacogenetics of the Statin Response
    ERNST SCHAEFER; Fiscal Year: 2005
    Coronary heart disease (CHD) is the leading cause of death and disability in our society. Most CHD deaths occur in subjects over 70 years of age...
  63. Pharmacogenetics of the Statin Response
    ERNST SCHAEFER; Fiscal Year: 2003
    Coronary heart disease (CHD) is the leading cause of death and disability in our society. Most CHD deaths occur in subjects over 70 years of age...
  64. Pharmacogenetics of the Statin Response
    ERNST SCHAEFER; Fiscal Year: 2006
    Coronary heart disease (CHD) is the leading cause of death and disability in our society. Most CHD deaths occur in subjects over 70 years of age...
  65. Pharmacogenetics of the Statin Response
    ERNST SCHAEFER; Fiscal Year: 2004
    Coronary heart disease (CHD) is the leading cause of death and disability in our society. Most CHD deaths occur in subjects over 70 years of age...
  66. Neutrophil Accumulation in Bacterial Pneumonia
    Samithamby Jeyaseelan; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Bacterial pneumonia is a leading cause of death. Recruitment of neutrophils into the lungs is one of the most important defense mechanisms in the initial host defense against bacterial infection...
  67. Neutrophil Accumulation in Bacterial Pneumonia
    Samithamby Jeyaseelan; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Bacterial pneumonia is a leading cause of death. Recruitment of neutrophils into the lungs is one of the most important defense mechanisms in the initial host defense against bacterial infection...
  68. Neutrophil Accumulation in Bacterial Pneumonia
    Samithamby Jeyaseelan; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Bacterial pneumonia is a leading cause of death. Recruitment of neutrophils into the lungs is one of the most important defense mechanisms in the initial host defense against bacterial infection...
  69. HIV and HIV/HCV-Infection, Disease Progression, Oxidative Stress and Antioxidants
    Marianna Baum; Fiscal Year: 2007
    Co-infection with Hepatitis C (HCV) is becoming the main cause of death in HIV-infected patients in the United States. Among drug users the proportion of HIV/HCV co-infection is 50%-90%...
  70. HIV and HIV/HCV-Infection, Disease Progression, Oxidative Stress and Antioxidants
    Marianna K Baum; Fiscal Year: 2010
    Co-infection with Hepatitis C (HCV) is becoming the main cause of death in HIV-infected patients in the United States. Among drug users the proportion of HIV/HCV co-infection is 50%-90%...
  71. HIV and HIV/HCV-Infection, Disease Progression, Oxidative Stress and Antioxidants
    Marianna Baum; Fiscal Year: 2009
    Co-infection with Hepatitis C (HCV) is becoming the main cause of death in HIV-infected patients in the United States. Among drug users the proportion of HIV/HCV co-infection is 50%-90%...
  72. Fostering Opportunities for Nutrition and Global Health
    Wafaie Fawzi; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Malnutrition is the leading cause of death and disability worldwide, and is a major impediment to population health and economic development...
  73. Balance of Angiotensin II/Angiotensin (1-1): A Target in Ischemic Stroke
    Yanfang Chen; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Ischemic stroke is the third leading cause of death in the United States. There are limited avenues for reducing cerebral damage and promoting repair after ischemic stroke...
  74. Enhancing Clergy Suicide Prevention and Referral
    Richard Goldsworthy; Fiscal Year: 2009
    Suicide is the 2nd leading cause of death in persons aged 25-34, the 3rd leading cause of death among people in the age groups 10-14 and 15-24, and the 8th leading cause of male deaths...
  75. Enhancing Clergy Suicide Prevention and Referral
    RICHARD CHARLES GOLDSWORTHY; Fiscal Year: 2010
    Suicide is the 2nd leading cause of death in persons aged 25-34, the 3rd leading cause of death among people in the age groups 10-14 and 15-24, and the 8th leading cause of male deaths...
  76. NAAG Peptidase Inhibitors for the Treatment of Traumatic Brain Injury
    Jia Zhou; Fiscal Year: 2009
    ..It is estimated that severe TBI will become the third most common cause of death and disability globally by the year 2020. An estimated 1...
  77. MicroRNA Signature of Tamoxifen Resistance in Breast Cancer
    Sarmila Majumder; Fiscal Year: 2009
    ..Breast cancer is the second leading cause of death in women today and one of the most common cancers among women in North America...
  78. ROLE OF HSP 110 IN TAUOPATHY
    NAHID MIVECHI; Fiscal Year: 2009
    ..Potential Impact on Veteran's Heath care is that traumatic brain injury (TBI), which is the main cause of death and disability in people under 35 and a common occurrence in combat situations, leads to significant ..
  79. Cognitive and Neurologic Sequelae in Cerebral Malaria
    Chandy John; Fiscal Year: 2007
    ..Malaria is the leading cause of death in children under 5 years of age in Uganda...
  80. MOLECULAR BIOLOGY OF HEMORRHAGIC SHOCK
    Timothy Billiar; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Trauma is the leading cause of death in this country in people under the age of 54 years...
  81. Education for Healthcare Providers of Alaska Natives
    Anne Lanier; Fiscal Year: 2005
    Cancer is now the leading cause of death for Alaska Natives (AN) surpassing trauma and infectious diseases that were the leading causes of death for many years. As recently as 1950,cancer was considered a rare disease in AN...
  82. Education for Healthcare Providers of Alaska Natives
    Anne Lanier; Fiscal Year: 2004
    Cancer is now the leading cause of death for Alaska Natives (AN) surpassing trauma and infectious diseases that were the leading causes of death for many years. As recently as 1950,cancer was considered a rare disease in AN...
  83. Education for Healthcare Providers of Alaska Natives
    Anne Lanier; Fiscal Year: 2007
    Cancer is now the leading cause of death for Alaska Natives (AN) surpassing trauma and infectious diseases that were the leading causes of death for many years. As recently as 1950,cancer was considered a rare disease in AN...
  84. Education for Healthcare Providers of Alaska Natives
    Anne Lanier; Fiscal Year: 2006
    Cancer is now the leading cause of death for Alaska Natives (AN) surpassing trauma and infectious diseases that were the leading causes of death for many years. As recently as 1950,cancer was considered a rare disease in AN...
  85. MOLECULAR BIOLOGY OF HEMORRHAGIC SHOCK
    Timothy R Billiar; Fiscal Year: 2010
    Trauma is the leading cause of death in this country in people under the age of 54 years...
  86. CTRIP Ex-vivo perfusion and ventilation of lungs to assess transplant suitability
    Thomas Egan; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Lung disease is the fourth leading cause of death in the U.S...
  87. Domestic endotoxin exposure and chronic obstructive pulmonary disease
    Nadia Hansel; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States and is a progressive disease characterized by lung injury and inflammation...
  88. A dataset for the study of the social determinants of health.
    Peter Muennig; Fiscal Year: 2009
    ..This dataset will greatly advance scientific understanding of the social causation of disease and health disparities. ..
  89. Vitamin D and Clinical Outcomes in Chronic Hemodialysis Patients
    Michel Chonchol; Fiscal Year: 2009
    ..In addition, it would provide a sound basis for a large clinical trial of vitamin D supplementation to improve the very poor clinical outcomes of dialysis patients. ..