cause of death

Summary

Summary: Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint.

Top Publications

  1. ncbi Socioeconomic inequalities in health in 22 European countries
    Johan P Mackenbach
    Department of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands
    N Engl J Med 358:2468-81. 2008
  2. pmc Mortality in relation to smoking: 50 years' observations on male British doctors
    Richard Doll
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, Radcliffe Infirmary, Oxford OX2 6HE
    BMJ 328:1519. 2004
  3. ncbi Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data
    Alan D Lopez
    School of Population Health, University of Queensland, Brisbane 4006, Australia
    Lancet 367:1747-57. 2006
  4. ncbi 4 million neonatal deaths: when? Where? Why?
    Joy E Lawn
    Saving Newborn Lives Save the Children USA, and International Perinatal Care Unit, Institute of Child Health, London, Cape Town, South Africa
    Lancet 365:891-900. 2005
  5. ncbi A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time?
    Sukanta Saha
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol Q4076, Australia
    Arch Gen Psychiatry 64:1123-31. 2007
  6. pmc Counting the dead and what they died from: an assessment of the global status of cause of death data
    Colin D Mathers
    Evidence and Information for Policy, World Health Organization, Geneva, Switzerland
    Bull World Health Organ 83:171-7. 2005
  7. ncbi Where and why are 10 million children dying every year?
    Robert E Black
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Lancet 361:2226-34. 2003
  8. ncbi Verbal autopsy: methods in transition
    Edward Fottrell
    Umeå Centre for Global Health Research, Division of Epidemiology and Global Health, Department of Public Health and Clinical Medicine, Umea University, SE 901 85 Umea, Sweden
    Epidemiol Rev 32:38-55. 2010
  9. ncbi Body-mass index and mortality in Korean men and women
    Sun Ha Jee
    Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea
    N Engl J Med 355:779-87. 2006
  10. pmc Implications of mortality transition for primary health care in rural South Africa: a population-based surveillance study
    Stephen M Tollman
    MRC Wits Rural Public Health and Health Transitions Research Unit Agincourt, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa
    Lancet 372:893-901. 2008

Detail Information

Publications362 found, 100 shown here

  1. ncbi Socioeconomic inequalities in health in 22 European countries
    Johan P Mackenbach
    Department of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands
    N Engl J Med 358:2468-81. 2008
    ..Comparisons among countries can help to identify opportunities for the reduction of inequalities in health. We compared the magnitude of inequalities in mortality and self-assessed health among 22 countries in all parts of Europe...
  2. pmc Mortality in relation to smoking: 50 years' observations on male British doctors
    Richard Doll
    Clinical Trial Service Unit and Epidemiological Studies Unit CTSU, Radcliffe Infirmary, Oxford OX2 6HE
    BMJ 328:1519. 2004
    ..To compare the hazards of cigarette smoking in men who formed their habits at different periods, and the extent of the reduction in risk when cigarette smoking is stopped at different ages...
  3. ncbi Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data
    Alan D Lopez
    School of Population Health, University of Queensland, Brisbane 4006, Australia
    Lancet 367:1747-57. 2006
    ..Our aim was to calculate the global burden of disease and risk factors for 2001, to examine regional trends from 1990 to 2001, and to provide a starting point for the analysis of the Disease Control Priorities Project (DCPP)...
  4. ncbi 4 million neonatal deaths: when? Where? Why?
    Joy E Lawn
    Saving Newborn Lives Save the Children USA, and International Perinatal Care Unit, Institute of Child Health, London, Cape Town, South Africa
    Lancet 365:891-900. 2005
    ..Low birthweight is an important indirect cause of death. Maternal complications in labour carry a high risk of neonatal death, and poverty is strongly associated with ..
  5. ncbi A systematic review of mortality in schizophrenia: is the differential mortality gap worsening over time?
    Sukanta Saha
    Queensland Centre for Mental Health Research, The Park Centre for Mental Health, Wacol Q4076, Australia
    Arch Gen Psychiatry 64:1123-31. 2007
    ..Despite improvements in mental health services in recent decades, it is unclear whether the risk of mortality in schizophrenia has changed over time...
  6. pmc Counting the dead and what they died from: an assessment of the global status of cause of death data
    Colin D Mathers
    Evidence and Information for Policy, World Health Organization, Geneva, Switzerland
    Bull World Health Organ 83:171-7. 2005
    ..We sought to assess the current status of global data on death registration and to examine several indicators of data completeness and quality...
  7. ncbi Where and why are 10 million children dying every year?
    Robert E Black
    Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Lancet 361:2226-34. 2003
    ..A better understanding of child health epidemiology could contribute to more effective approaches to saving children's lives...
  8. ncbi Verbal autopsy: methods in transition
    Edward Fottrell
    Umeå Centre for Global Health Research, Division of Epidemiology and Global Health, Department of Public Health and Clinical Medicine, Umea University, SE 901 85 Umea, Sweden
    Epidemiol Rev 32:38-55. 2010
    ..There is an urgent need for clarified thinking about the overall objectives of population-level cause-of-death measurement and harmonized efforts in empirical methodological research...
  9. ncbi Body-mass index and mortality in Korean men and women
    Sun Ha Jee
    Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea
    N Engl J Med 355:779-87. 2006
    ..Obesity is associated with diverse health risks, but the role of body weight as a risk factor for death remains controversial...
  10. pmc Implications of mortality transition for primary health care in rural South Africa: a population-based surveillance study
    Stephen M Tollman
    MRC Wits Rural Public Health and Health Transitions Research Unit Agincourt, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa
    Lancet 372:893-901. 2008
    ..We investigated the extent and nature of this health transition and considered the implications for primary health care...
  11. ncbi Effect of a multifactorial intervention on mortality in type 2 diabetes
    Peter Gaede
    Steno Diabetes Center, Copenhagen, Denmark
    N Engl J Med 358:580-91. 2008
    ..We evaluated whether this approach would have an effect on the rates of death from any cause and from cardiovascular causes...
  12. ncbi Global and regional causes of death
    Colin D Mathers
    Department of Health statistics and informatics, World Health Organization, 1211 Geneva, Switzerland
    Br Med Bull 92:7-32. 2009
    ..The paper also examines some of the data gaps, uncertainties and limitations in the resulting mortality estimates...
  13. ncbi Stillbirths: Where? When? Why? How to make the data count?
    Joy E Lawn
    Saving Newborn Lives Save the Children, Cape Town, South Africa
    Lancet 377:1448-63. 2011
    ..A new focus on all deaths around the time of birth is crucial to inform programmatic investment...
  14. ncbi International study of temperature, heat and urban mortality: the 'ISOTHURM' project
    Anthony J McMichael
    National Centre for Epidemiology and Population Health, The Australian National University College of Medicine and Health Sciences, Canberra, Australia
    Int J Epidemiol 37:1121-31. 2008
    ..This study describes heat- and cold-related mortality in 12 urban populations in low- and middle-income countries, thereby extending knowledge of how diverse populations, in non-OECD countries, respond to temperature extremes...
  15. ncbi Effects of cold weather on mortality: results from 15 European cities within the PHEWE project
    A Analitis
    Department of Hygiene, Epidemiology and Medical Statistics, Medical School, University of Athens, Athens, Greece
    Am J Epidemiol 168:1397-408. 2008
    ..Cold-related mortality is an important public health problem across Europe. It should not be underestimated by public health authorities because of the recent focus on heat-wave episodes...
  16. ncbi Actual causes of death in the United States, 2000
    Ali H Mokdad
    Division of Adult and Community Health, Centers for Disease Control and Prevention, Atlanta, GA, USA
    JAMA 291:1238-45. 2004
    ..Modifiable behavioral risk factors are leading causes of mortality in the United States. Quantifying these will provide insight into the effects of recent trends and the implications of missed prevention opportunities...
  17. pmc Temperature, temperature extremes, and mortality: a study of acclimatisation and effect modification in 50 US cities
    M Medina-Ramón
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    Occup Environ Med 64:827-33. 2007
    ..The authors examined the increase in mortality associated with hot and cold temperature in different locations, the determinants of the variability in effect estimates, and its implications for adaptation...
  18. pmc Projections of global mortality and burden of disease from 2002 to 2030
    Colin D Mathers
    Evidence and Information for Policy Cluster, World Health Organization, Geneva, Switzerland
    PLoS Med 3:e442. 2006
    ..This paper describes the methods, assumptions, input data, and results...
  19. ncbi Cause-specific excess deaths associated with underweight, overweight, and obesity
    Katherine M Flegal
    National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, MD 20782, USA
    JAMA 298:2028-37. 2007
    ..The association of body mass index (BMI) with cause-specific mortality has not been reported for the US population...
  20. pmc The global burden of injuries
    E G Krug
    World Health Organization, Geneva, Switzerland
    Am J Public Health 90:523-6. 2000
    ..Road traffic injuries are the 10th leading cause of death and the 9th leading cause of the burden of disease; self-inflicted injuries, falls, and interpersonal violence ..
  21. ncbi The validity of the diagnosis of acute myocardial infarction in routine statistics: a comparison of mortality and hospital discharge data with the Danish MONICA registry
    Mette Madsen
    National Institute of Public Health, Svanemøllevej 25, DK 2100 Copenhagen, Denmark
    J Clin Epidemiol 56:124-30. 2003
    ..For events with MI as the primary diagnosis or underlying cause of death the predictive value was 93.6% and sensitivity 77.6% when compared to DANMONICA definite or possible MI...
  22. ncbi Widening socioeconomic inequalities in mortality in six Western European countries
    Johan P Mackenbach
    Department of Public Health, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Int J Epidemiol 32:830-7. 2003
    ....
  23. ncbi Validation and application of verbal autopsies in a rural area of South Africa
    K Kahn
    Health Systems Development Unit, Department of Community Health, University of the Witwatersrand, Johannesburg, South Africa
    Trop Med Int Health 5:824-31. 2000
    ..To validate the causes of death determined with a single verbal autopsy instrument covering all age groups in the Agincourt subdistrict of rural South Africa...
  24. ncbi The Danish Register of Causes of Death
    Karin Helweg-Larsen
    National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark
    Scand J Public Health 39:26-9. 2011
    ..Cause-specific mortality statistics is a valuable source for the identification of risk factors for poor public health...
  25. ncbi Relative risk of cardiovascular and cancer mortality in people with severe mental illness from the United Kingdom's General Practice Rsearch Database
    David P J Osborn
    Department of Mental Health Sciences, Royal Free Medical School, London, England
    Arch Gen Psychiatry 64:242-9. 2007
    ..People with severe mental illness (SMI) appear to have an elevated risk of death from cardiovascular disease, but results regarding cancer mortality are conflicting...
  26. pmc Adult mortality and probable cause of death in rural northern Malawi in the era of HIV treatment
    Menard Chihana
    Karonga Prevention Study, Chilumba, Malawi
    Trop Med Int Health 17:e74-83. 2012
    ..risk of cardiovascular diseases, raising the prospects of an accelerated transition towards NCD as the primary cause of death. We report population-based data to investigate changes in cause of death owing to NCD during the first 4 ..
  27. ncbi Causes of death among persons with AIDS in the era of highly active antiretroviral therapy: New York City
    Judith E Sackoff
    HIV Epidemiology Program, Bureau of HIV AIDS Prevention and Control, New York City Department of Health and Mental Hygiene, New York, New York 10013, USA
    Ann Intern Med 145:397-406. 2006
    ..Monitoring the full spectrum of causes of death among persons with AIDS is increasingly important as survival improves because of highly active antiretroviral therapy...
  28. pmc Heat-related and cold-related deaths in England and Wales: who is at risk?
    S Hajat
    Public and Environmental Health Research Unit, London School of Hygiene and Tropical Medicine, London, UK
    Occup Environ Med 64:93-100. 2007
    ..Despite the high burden from exposure to both hot and cold weather each year in England and Wales, there has been relatively little investigation on who is most at risk, resulting in uncertainties in informing government interventions...
  29. pmc Probabilistic methods for verbal autopsy interpretation: InterVA robustness in relation to variations in a priori probabilities
    Edward Fottrell
    Department of Public Health and Clinical Medicine, Umeå Centre for Global Health Research, Umea University, Umea, Sweden
    PLoS ONE 6:e27200. 2011
    ..The extent to which InterVA's ability to characterise a population's mortality composition might be sensitive to variations in these a priori probabilities was investigated...
  30. pmc Trends in all-cause and cardiovascular disease mortality among women and men with and without diabetes mellitus in the Framingham Heart Study, 1950 to 2005
    Sarah Rosner Preis
    Framingham Heart Study of the National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA
    Circulation 119:1728-35. 2009
    ..Despite population declines in all-cause mortality, women with diabetes mellitus may have experienced an increase in mortality rates compared with men...
  31. ncbi The epidemiology of excess mortality in people with mental illness
    David Lawrence
    Centre for Developmental Health, Curtin University of Technology and Telethon Institute for Child Health Research, Perth, Australia
    Can J Psychiatry 55:752-60. 2010
    ..to investigate the burden of excess mortality among people with mental illness in developed countries, how it is distributed, and whether it has changed over time...
  32. pmc Prospective study of one million deaths in India: rationale, design, and validation results
    Prabhat Jha
    Centre for Global Health Research, Public Health Sciences, St Michael s Hospital, McLaughlin Centre for Molecular Medicine, University of Toronto, Toronto, Canada
    PLoS Med 3:e18. 2006
    ..We report here on the rationale, design, and implementation of the world's largest prospective study of the causes and correlates of mortality...
  33. ncbi Excess mortality in bipolar and unipolar disorder in Sweden
    U Osby
    Department of Clinical Neuroscience, Karolinska Institutet, Karolinska sjukhuset S4, S 171 76 Stockholm, Sweden
    Arch Gen Psychiatry 58:844-50. 2001
    ..However, there has been no population-based study of mortality of patients followed up from the onset of the illness...
  34. ncbi A nationally representative case-control study of smoking and death in India
    Prabhat Jha
    Centre for Global Health Research, St Michael s Hospital, University of Toronto, Toronto, ON, Canada
    N Engl J Med 358:1137-47. 2008
    ..The nationwide effects of smoking on mortality in India have not been assessed reliably...
  35. ncbi Outcomes of Nordic mental health systems: life expectancy of patients with mental disorders
    Kristian Wahlbeck
    Nordic School of Public Health, Nordic Research Academy in Mental Health, Gothenburg, Sweden, and National Institute for Health and Welfare THL, Vaasa, Finland
    Br J Psychiatry 199:453-8. 2011
    ..People with mental disorders evince excess mortality due to natural and unnatural deaths. The relative life expectancy of people with mental disorders is a proxy measure of effectiveness of social policy and health service provision...
  36. pmc Lung cancer, cardiopulmonary mortality, and long-term exposure to fine particulate air pollution
    C Arden Pope
    Department of Economics, Brigham Young University, 142 FOB, Provo, UT 84602, USA
    JAMA 287:1132-41. 2002
    ..However, studies of health effects of long-term particulate air pollution have been less conclusive...
  37. pmc Causes of neonatal and child mortality in India: a nationally representative mortality survey
    Diego G Bassani
    Centre for Global Health Research, Li Ka Shing Knowledge Institute, St Michael s Hospital and Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5B 1W8, Canada
    Lancet 376:1853-60. 2010
    ..More than 2·3 million children died in India in 2005; however, the major causes of death have not been measured in the country. We investigated the causes of neonatal and child mortality in India and their differences by sex and region...
  38. pmc Population-level effect of HIV on adult mortality and early evidence of reversal after introduction of antiretroviral therapy in Malawi
    Andreas Jahn
    London School of Hygiene and Tropical Medicine, London, UK
    Lancet 371:1603-11. 2008
    ..We aimed to investigate mortality in a population before and after the introduction of free antiretroviral therapy, and therefore to assess the effects of such programmes on survival at the population level...
  39. ncbi Comparisons of causes of death and mortality rates among HIV-infected persons: analysis of the pre-, early, and late HAART (highly active antiretroviral therapy) eras
    Nancy F Crum
    Infectious Diseases Division, Clinical Investigation Department, Naval Medical Center San Diego, San Diego, CA 92134 1005, USA
    J Acquir Immune Defic Syndr 41:194-200. 2006
    ..Comparisons of death-related variables during the 3 eras were performed...
  40. ncbi Factors associated with specific causes of death amongst HIV-positive individuals in the D:A:D Study
    Colette Smith
    Research Department of Infection and Population Health, UCL, Royal Free Campus, London, UK
    AIDS 24:1537-48. 2010
    To investigate any emerging trends in causes of death amongst HIV-positive individuals in the current cART era, and to investigate the factors associated with each specific cause of death.
  41. pmc Cause-specific mortality rates in sub-Saharan Africa and Bangladesh
    Martin Adjuik
    Navrongo Health Research Centre, Ghana
    Bull World Health Organ 84:181-8. 2006
    ..To provide internationally comparable data on the frequencies of different causes of death...
  42. ncbi Suicide rates in China, 1995-99
    Michael R Phillips
    Beijing Suicide Research and Prevention Center, Beijing Hui Long Guan Hospital, Beijing 100096, People s Republic of China
    Lancet 359:835-40. 2002
    ..We aimed to present an accurate picture of the current pattern of suicide in China on the basis of conservative estimates of suicide rates in different population cohorts...
  43. ncbi A multicounty analysis identifying the populations vulnerable to mortality associated with high ambient temperature in California
    Rupa Basu
    Air Pollution Epidemiology Section, California Office of Environmental Health Hazard Assessment, Oakland, CA 94612, USA
    Am J Epidemiol 168:632-7. 2008
    ..0, 7.9). No differences were found by gender or educational level. To prevent the mortality associated with ambient temperature, persons with cardiovascular disease, the elderly, infants, and Blacks among others should be targeted...
  44. ncbi Cause of death distribution with InterVA and physician coding in a rural area of Burkina Faso
    Heribert Ramroth
    Institute of Public Health, University Hospital of Heidelberg, Heidelberg, Germany
    Trop Med Int Health 17:904-13. 2012
    To compare the cause of death distribution using the Physician Coded Verbal Autopsy approach versus the Interpreting Verbal Autopsy model, based on information from a French verbal autopsy questionnaire, in rural north-western Burkina Faso...
  45. pmc Validity of verbal autopsy procedures for determining malaria deaths in different epidemiological settings in Uganda
    Arthur Mpimbaza
    Uganda Malaria Surveillance Project Kampala, Kampala, Uganda
    PLoS ONE 6:e26892. 2011
    Verbal autopsy (VA) procedures can be used to estimate cause of death in settings with inadequate vital registries...
  46. ncbi Long-term mortality in a nationwide cohort of childhood-onset type 1 diabetic patients in Norway
    T Skrivarhaug
    Department of Pediatrics, Ulleval University Hospital, N 0407 Oslo, Norway
    Diabetologia 49:298-305. 2006
    ..We examined long-term total and cause-specific mortality in a nationwide, population-based Norwegian cohort of patients with childhood-onset type 1 diabetes...
  47. ncbi All-cause mortality associated with physical activity during leisure time, work, sports, and cycling to work
    L B Andersen
    Institute for Exercise and Sport Sciences, University of Copenhagen, Denmark
    Arch Intern Med 160:1621-8. 2000
    ..Physical activity is associated with low mortality in men, but little is known about the association in women, different age groups, and everyday activity...
  48. pmc Early mortality in adults initiating antiretroviral therapy (ART) in low- and middle-income countries (LMIC): a systematic review and meta-analysis
    Amita Gupta
    School of Medicine, Johns Hopkins University, Baltimore, Maryland, United States of America
    PLoS ONE 6:e28691. 2011
    ....
  49. ncbi Autopsy causes of death in HIV-positive individuals in sub-Saharan Africa and correlation with clinical diagnoses
    Janneke A Cox
    Institute of Tropical Medicine, Antwerp, Belgium
    AIDS Rev 12:183-94. 2010
    ..Tuberculosis was the most frequent, present in 21-54% of HIV-positive adults and was considered the cause of death in 32-45%...
  50. pmc Exposing misclassified HIV/AIDS deaths in South Africa
    Jeanette Kurian Birnbaum
    Institute for Health Metrics and Evaluation, University of Washington, 2301 5th Avenue Suite 600, Seattle, WA 98121, United States of America
    Bull World Health Organ 89:278-85. 2011
    ..To quantify the deaths from human immunodeficiency virus (HIV) infection or acquired immunodeficiency syndrome (AIDS) that are misattributed to other causes in South Africa's death registration data and to adjust for this bias...
  51. pmc Moving from data on deaths to public health policy in Agincourt, South Africa: approaches to analysing and understanding verbal autopsy findings
    Peter Byass
    Umeå Centre for Global Health Research, Department of Public Health and Clinical Medicine, Umea University, Sweden
    PLoS Med 7:e1000325. 2010
    b>Cause of death data are an essential source for public health planning, but their availability and quality are lacking in many parts of the world...
  52. pmc Adverse socioeconomic conditions in childhood and cause specific adult mortality: prospective observational study
    G D Smith
    Department of Social Medicine, University of Bristol, Canynge Hall, Bristol BS8 2PR
    BMJ 316:1631-5. 1998
    ..To investigate the association between social circumstances in childhood and mortality from various causes of death in adulthood...
  53. pmc The impact of heat waves and cold spells on mortality rates in the Dutch population
    M M Huynen
    International Centre for Integrative Studies, Maastricht University, Maastricht, The Netherlands
    Environ Health Perspect 109:463-70. 2001
    ..The results concerning the forward displacement of deaths due to heat waves were not conclusive. We found no cold-induced forward displacement of deaths...
  54. ncbi Mortality associated with influenza and respiratory syncytial virus in the United States
    William W Thompson
    Influenza Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    JAMA 289:179-86. 2003
    ..Influenza and respiratory syncytial virus (RSV) cause substantial morbidity and mortality. Statistical methods used to estimate deaths in the United States attributable to influenza have not accounted for RSV circulation...
  55. pmc Refining a probabilistic model for interpreting verbal autopsy data
    Peter Byass
    Umeå International School of Public Health, Umea University, Umea, Sweden
    Scand J Public Health 34:26-31. 2006
    To build on the previously reported development of a Bayesian probabilistic model for interpreting verbal autopsy (VA) data, attempting to improve the model's performance in determining cause of death and to reassess it.
  56. ncbi Coronary heart disease mortality among young adults in the U.S. from 1980 through 2002: concealed leveling of mortality rates
    Earl S Ford
    Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    J Am Coll Cardiol 50:2128-32. 2007
    ..The objective of our study was to examine age-specific mortality rates from coronary heart disease (CHD), particularly those among younger adults...
  57. ncbi Mortality displacement of heat-related deaths: a comparison of Delhi, São Paulo, and London
    Shakoor Hajat
    London School of Hygiene and Tropical Medicine, United Kingdom
    Epidemiology 16:613-20. 2005
    ..We compare the extent to which short-term mortality displacement can explain heat deaths in Delhi, São Paulo, and London given contrasting demographic and health profiles...
  58. ncbi Mortality trends in men and women with diabetes, 1971 to 2000
    Edward W Gregg
    National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3727, USA
    Ann Intern Med 147:149-55. 2007
    ..Whether mortality rates among diabetic adults or excess mortality associated with diabetes in the United States has declined in recent decades is not known...
  59. pmc Sample registration of vital events with verbal autopsy: a renewed commitment to measuring and monitoring vital statistics
    Philip W Setel
    Department of Epidemiology and MEASURE Evaluation, Carolina Population Center, University of North Carolina, Chapel Hill, NC 27516, USA
    Bull World Health Organ 83:611-7. 2005
    ..If the global community wishes to have mortality measurements 5 or 10 years hence, the foundation stones of SVR must be laid today...
  60. ncbi The length of unemployment predicts mortality, differently in men and women, and by cause of death: a six year mortality follow-up of the Swedish 1992-1996 recession
    Anthony M Garcy
    Center for Health Equity Studies CHESS, Stockholm University Karolinska Institute, Stockholm, Sweden
    Soc Sci Med 74:1911-20. 2012
    ..This was best described by a cubic function for men and a linear function for women. Behind this pattern, different causes-of-death varied in their relation to the accumulation of unemployment...
  61. pmc Trends of mortality and cause of death among HIV-infected patients in Korea, 1990-2011
    Sun Hee Lee
    Deparment of Internal Medicine, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea
    J Korean Med Sci 28:67-73. 2013
    ..Mortality and cause of death were analyzed in three treatment periods; pre-HAART (1990-1997), early-HAART (1998-2001), and late-HAART ..
  62. ncbi Is worsening multiple organ failure the cause of death in patients with severe sepsis?
    Jean Louis Vincent
    Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Belgium
    Crit Care Med 39:1050-5. 2011
    ..We used the INDEPTH (International Integrated Database for the Evaluation of Severe Sepsis and Drotrecogin alfa activated) database to investigate the reported cause of death in patients with severe sepsis.
  63. ncbi Mortality among patients admitted to hospitals on weekends as compared with weekdays
    C M Bell
    Department of Medicine, University of Toronto, Sunnybrook and Women's College Health Sciences Centre, ON, Canada
    N Engl J Med 345:663-8. 2001
    ..CONCLUSIONS: Patients with some serious medical conditions are more likely to die in the hospital if they are admitted on a weekend than if they are admitted on a weekday...
  64. ncbi Pulmonary function is a long-term predictor of mortality in the general population: 29-year follow-up of the Buffalo Health Study
    H J Schünemann
    Department of Social and Preventive Medicine, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, NY 14214 3000, USA
    Chest 118:656-64. 2000
    ..The purpose of this study was to investigate the predictive value of pulmonary function by gender after 29 years of follow-up...
  65. pmc High ambient temperature and mortality: a review of epidemiologic studies from 2001 to 2008
    Rupa Basu
    California Office of Environmental Hazard Assessment, Air Pollution Epidemiology Section, Oakland, California, USA
    Environ Health 8:40. 2009
    ..This review examines recent evidence on mortality from elevated ambient temperature for studies published from January 2001 to December 2008...
  66. ncbi WHO estimates of the causes of death in children
    Jennifer Bryce
    WHO, Geneva, Switzerland
    Lancet 365:1147-52. 2005
    ..Child survival efforts can be effective only if they are based on accurate information about causes of deaths. Here, we report on a 4-year effort by WHO to improve the accuracy of this information...
  67. pmc Risk of all-cause mortality associated with nonfatal AIDS and serious non-AIDS events among adults infected with HIV
    Jacqueline Neuhaus
    University of Minnesota, Minneapolis, Minnesota, USA
    AIDS 24:697-706. 2010
    ....
  68. ncbi Validity of verbal autopsy procedures for determining cause of death in Tanzania
    Philip W Setel
    Department of Epidemiology and MEASURE Evaluation, Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA
    Trop Med Int Health 11:681-96. 2006
    ..Verbal autopsy is an important method for deriving cause-specific mortality estimates where disease burdens are greatest and routine cause-specific mortality data do not exist...
  69. ncbi Who dies from what? Determining cause of death in South Africa's rural north-east
    K Kahn
    Health Systems Development Unit, University of the Witwatersrand, Johannesburg, South Africa
    Trop Med Int Health 4:433-41. 1999
    Information on cause of death is essential for rational public health planning, yet mortality data in South Africa is limited. In the Agincourt subdistrict, verbal autopsies (VA) have been used to determine cause of death...
  70. ncbi 50-year mortality trends in children and young people: a study of 50 low-income, middle-income, and high-income countries
    Russell M Viner
    University College London Institute of Child Health, London, UK
    Lancet 377:1162-74. 2011
    ..Global attention has focused on mortality in children younger than 5 years. We analysed global mortality data for people aged 1-24 years across a 50-year period...
  71. pmc Using cohort studies to estimate mortality among injecting drug users that is not attributable to AIDS
    L Degenhardt
    National Drug and Alcohol Research Centre, University of New South Wales, Sydney NSW 2052, Australia
    Sex Transm Infect 82:iii56-63. 2006
    ..The current review provides estimates of the excess non-AIDS mortality among IDUs...
  72. ncbi Stroke declines from third to fourth leading cause of death in the United States: historical perspective and challenges ahead
    Amytis Towfighi
    Division of Stroke and Critical Care, Department of Neurology, University of Southern California, Los Angeles, CA, USA
    Stroke 42:2351-5. 2011
    Stroke recently declined from the third to the fourth leading cause of death in the United States, its first rank transition among sources of American mortality in nearly 75 years.
  73. ncbi Civil registration systems and vital statistics: successes and missed opportunities
    Prasanta Mahapatra
    Institute of Health Systems, Hyderabad, India
    Lancet 370:1653-63. 2007
    ..However, worldwide efforts to improve data have been limited to sporadic and short-term measures. We conclude that countries and developmental partners have not recognised that civil registration systems are a priority...
  74. ncbi Alcohol and Russian mortality: a continuing crisis
    David A Leon
    London School of Hygiene and Tropical Medicine, London, UK and Max Planck Institute for Demographic Research, Rostock, Germany
    Addiction 104:1630-6. 2009
    ..In 2007, male life expectancy at birth was 61 years, while for females it was 74 years. Alcohol is implicated particularly in deaths among working-age men...
  75. ncbi Ethnic-immigrant differentials in health behaviors, morbidity, and cause-specific mortality in the United States: an analysis of two national data bases
    Gopal K Singh
    National Institutes of Health, Bethesda, MD 20892 8316, USA
    Hum Biol 74:83-109. 2002
    ....
  76. pmc Alcohol and cause-specific mortality in Russia: a retrospective case-control study of 48,557 adult deaths
    David Zaridze
    Department of Epidemiology and Prevention, N N Blokhin Russian Cancer Research Centre, Moscow, Russia
    Lancet 373:2201-14. 2009
    ..Our case-control study investigated the effects of alcohol consumption on male and female cause-specific mortality...
  77. ncbi Cardiovascular and noncardiovascular mortality among patients starting dialysis
    Dinanda J de Jager
    Department of Clinical Epidemiology, Leiden University Medical Center, C7 104, PO Box 9600, 2300 RC Leiden, The Netherlands
    JAMA 302:1782-9. 2009
    Cardiovascular mortality is considered the main cause of death in patients receiving dialysis and is 10 to 20 times higher in such patients than in the general population.
  78. pmc All-cause mortality among people with serious mental illness (SMI), substance use disorders, and depressive disorders in southeast London: a cohort study
    Chin Kuo Chang
    King s College London, Section of Epidemiology, Dept of Health Service and Population Research, Institute of Psychiatry, London, UK
    BMC Psychiatry 10:77. 2010
    ..Our aim was to characterize vulnerable groups for excess mortality among people with SMI, substance use disorders, depressive episode, and recurrent depressive disorder...
  79. ncbi Grip strength, body composition, and mortality
    Catharine R Gale
    MRC Epidemiology Resource Centre, University of Southampton, Southampton General Hospital, Southampton, UK
    Int J Epidemiol 36:228-35. 2007
    ..We investigated the relation between grip strength, body composition, and cause-specific and total mortality in 800 men and women aged 65 and over...
  80. ncbi Low serum 25-hydroxyvitamin D levels are associated with increased all-cause mortality risk in a general population: the Tromsø study
    Moira Strand Hutchinson
    Department of Clinical Medicine, University of Tromsø, Tromsø, Norway
    Eur J Endocrinol 162:935-42. 2010
    ..Based on this, low serum 25(OH)D levels should be associated with higher all-cause mortality in a general population. This hypothesis was tested in the present study...
  81. ncbi Mortality due to systemic mycoses as a primary cause of death or in association with AIDS in Brazil: a review from 1996 to 2006
    Marli Prado
    Departamento de Epidemiologia, Escola de Saúde Pública, Universidade de Sao Paulo, Sao Paulo, SP, Brasil
    Mem Inst Oswaldo Cruz 104:513-21. 2009
    ..When analysed as the underlying cause of death, paracoccidioidomycosis represented the most important cause of deaths among systemic mycoses (approximately ..
  82. ncbi Prospective study of serum 25-hydroxyvitamin D level, cardiovascular disease mortality, and all-cause mortality in older U.S. adults
    Adit A Ginde
    Department of Emergency Medicine, School of Medicine, University of Colorado Denver, 12401 E 17th Avenue, B 215, Aurora, CO 80045
    J Am Geriatr Soc 57:1595-603. 2009
    ..To evaluate the association between serum 25-hydroxyvitamin D (25(OH)D) levels and mortality in a representative U.S. sample of older adults...
  83. ncbi Initial burden of disease estimates for South Africa, 2000
    Debbie Bradshaw
    Burden of Disease Research Unit, Medical Research Council of South Africa, Tygerberg, W Cape
    S Afr Med J 93:682-8. 2003
    ..e. the years lived with disability (YLDs), are obtained to calculate disability-adjusted life years (DALYs); and the impact of AIDS on premature mortality in the year 2010 is assessed...
  84. ncbi Causes of death in hospitalized adults with a premortem diagnosis of tuberculosis: an autopsy study
    Neil A Martinson
    Johns Hopkins University Center for TB Research, Baltimore, Maryland, USA
    AIDS 21:2043-50. 2007
    ..To ascertain the immediate and underlying causes of death in adults who died in hospital with a premortem diagnosis of tuberculosis...
  85. ncbi Cancer survival in five continents: a worldwide population-based study (CONCORD)
    Michel P Coleman
    Cancer Research UK Cancer Survival Group, Non communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London, UK
    Lancet Oncol 9:730-56. 2008
    ..This is, to our knowledge, the first worldwide analysis of cancer survival, with standard quality-control procedures and identical analytic methods for all datasets...
  86. pmc Neonatal mortality, risk factors and causes: a prospective population-based cohort study in urban Pakistan
    Imtiaz Jehan
    Aga Khan University, Karachi, Pakistan
    Bull World Health Organ 87:130-8. 2009
    ..To evaluate the prevalence, sex distribution and causes of neonatal mortality, as well as its risk factors, in an urban Pakistani population with access to obstetric and neonatal care...
  87. ncbi Association of body mass index with suicide mortality: a prospective cohort study of more than one million men
    Patrik K E Magnusson
    Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Am J Epidemiol 163:1-8. 2006
    ..based on the Swedish Military Service Conscription Register, the Population and Housing Censuses, and the Cause of Death Register...
  88. ncbi Pathology and causes of death in a group of 128 predominantly HIV-positive patients in Botswana, 1997-1998
    N A Ansari
    The BOTUSA Project, Gaborone, Botswana
    Int J Tuberc Lung Dis 6:55-63. 2002
    ..Little is known about causes of death in countries of southern Africa seriously affected by the HIV/AIDS epidemic...
  89. ncbi Impact of the 2003 heatwave on all-cause mortality in 9 French cities
    Alain Le Tertre
    Environmental Health Department, Institut de Veille Sanitaire, Paris, France
    Epidemiology 17:75-9. 2006
    ..A heatwave occurred in France in August 2003, with an accompanying excess of all-cause mortality. This study quantifies this excess mortality and investigates a possible harvesting effect in the few weeks after the heatwave...
  90. pmc Causes of early mortality in HIV-infected TB suspects in an East African referral hospital
    Rachel Kyeyune
    Makerere University, Kampala, Uganda
    J Acquir Immune Defic Syndr 55:446-50. 2010
    Respiratory infections are a leading cause of death in Africa, especially among HIV-infected patients. Data on the etiology of fatal respiratory diseases are largely based on autopsy studies...
  91. ncbi The Danish registers of causes of death
    K Juel
    Danish Institute for Clinical Epidemiology, Copenhagen
    Dan Med Bull 46:354-7. 1999
    ..This paper describes the history of the registers, the data sources and access to data, and the research based upon the registers, presenting some examples of research activities...
  92. pmc A 10 year study of the cause of death in children under 15 years in Manhiça, Mozambique
    Jahit Sacarlal
    Centro de Investigação em Saúde da Manhiça CISM, Mozambique
    BMC Public Health 9:67. 2009
    ....
  93. pmc No cry at birth: global estimates of intrapartum stillbirths and intrapartum-related neonatal deaths
    Joy Lawn
    Saving Newborn Lives Save the Children, International Perinatal Care Unit, Institute of Child Health, London, England
    Bull World Health Organ 83:409-17. 2005
    ..7 to 1.2 million. Estimates for intrapartum stillbirths are not available. We aimed to estimate the numbers of intrapartum-related neonatal deaths and intrapartum stillbirths in the year 2000...
  94. ncbi Contribution of major diseases to disparities in mortality
    Mitchell D Wong
    Division of General Internal Medicine and Health Services Research, University of California at Los Angeles, Los Angeles 90095 1736, USA
    N Engl J Med 347:1585-92. 2002
    ..Mortality from all causes is higher for persons with fewer years of education and for blacks, but it is unknown which diseases contribute most to these disparities...
  95. ncbi The effect of early detection of occult brain metastases in HER2-positive breast cancer patients on survival and cause of death
    Anna Niwinska
    Department of Breast Cancer and Reconstructive Surgery, Maria Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
    Int J Radiat Oncol Biol Phys 77:1134-9. 2010
    ..is to evaluate disease-free survival, survival from the detection of brain metastases, overall survival, and cause of death in patients with occult brain metastases (Group I) vs. patients with symptomatic brain metastases (Group II).
  96. pmc The association between BMI and mortality using offspring BMI as an indicator of own BMI: large intergenerational mortality study
    George Davey Smith
    Medical Research Council Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, BS8 2BN
    BMJ 339:b5043. 2009
    ..To obtain valid estimates of the association between body mass index (BMI) and mortality by using offspring BMI as an instrumental variable for own BMI...
  97. pmc Are there differences in all-cause and coronary heart disease mortality between immigrants in Sweden and in their country of birth? A follow-up study of total populations
    Malin Gadd
    CeFAM Center for Family and Community Medicine, Neurotec, Karolinska Institutet, Stockholm, Sweden
    BMC Public Health 6:102. 2006
    ..The purpose of the present study was to analyse whether all-cause and coronary heart disease mortality differ between immigrants in Sweden and in the country of birth...
  98. ncbi Increased cause-specific mortality associated with 2003 heat wave in Essen, Germany
    Barbara Hoffmann
    Institute for Medical Informatics, Biometry and Epidemiology, University Hospital, University of Duisburg Essen, Essen, Germany
    J Toxicol Environ Health A 71:759-65. 2008
    ..Different mechanisms appear to influence cause-specific mortality, with strongest associations for respiratory mortality. Harvesting might play a role in mortality due to neoplasms...
  99. ncbi Post-mortem findings in harbour porpoises (Phocoena phocoena) from the German North and Baltic Seas
    U Siebert
    , , Frankfurter Strasse 96, 35392 Giessen, Germany
    J Comp Pathol 124:102-14. 2001
    ..Pneumonia was considered to be the cause of death in 46% of the stranded subadult and adult animals...
  100. ncbi Methodology of studies evaluating death certificate accuracy were flawed
    Lars Age Johansson
    Centre for Epidemiology, Swedish National Board of Health and Welfare, SE 106 30 Stockholm, Sweden
    J Clin Epidemiol 59:125-31. 2006
    ..Statistics on causes of death are important for epidemiologic research. Studies that evaluate the source data often give conflicting results, which raise questions about comparability and validity of methods...
  101. pmc Evaluating the InterVA model for determining AIDS mortality from verbal autopsies in the adult population of Addis Ababa
    Biruk Tensou
    Addis Ababa Mortality Surveillance Project, Faculty of Medicine, Addis Ababa University, Addis Ababa, Ethiopia
    Trop Med Int Health 15:547-53. 2010
    ..To evaluate the performance of a verbal autopsy (VA) expert algorithm (the InterVA model) for diagnosing AIDS mortality against a reference standard from hospital records that include HIV serostatus information in Addis Ababa, Ethiopia...

Research Grants74

  1. Prevention of Complications in Thalassemia
    Elliott P Vichinsky; Fiscal Year: 2011
    ..and underpin the programs to be implemented under this new project Infections are the second most common cause of death in thalassemia major...
  2. Periodontal Biomaterials with BITE (Biofilm Immunity via T-cell Enhancement)
    James D Bryers; Fiscal Year: 2012
    ..Nosocomial infections are the fourth leading cause of death in the U.S. with >2 million cases annually (or ~10% of American hospital patients)...
  3. Prevention of Acute Lung Injury by IL-6 activated STAT3
    Ana Moran; Fiscal Year: 2010
    Trauma is accompanied frequently by hemorrhagic shock and is the leading cause of death for those under 45 years old in the United States...
  4. Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of Sclerod
    Robert B Zurier; Fiscal Year: 2012
    ..leads to organ dysfunction including debilitating esophageal dysfunction and pulmonary fibrosis, the leading cause of death for SSc patients...
  5. Novel Mitochondrial Mechanisms of Ethanol-Induced Cardiac Injury in Aged Females
    DONNA HOPE KORZICK; Fiscal Year: 2010
    ..It is also important to note that heart disease remains the leading cause of death in post-menopausal women, with mortality rates surpassing those of age-matched men...
  6. Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
    BARBARA O'BRIEN; Fiscal Year: 2013
    ..Participants will be contacted annually to determine current health status. Follow up includes ascertainment of adverse medical outcomes, cancer incidence, cause of death, and mortality impact.
  7. Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
    Mona Fouad; Fiscal Year: 2013
    ..Participants will be contacted annually to determine current health status. Follow up includes ascertainment of adverse medical outcomes, cancer incidence, cause of death, and mortality impact.
  8. Pathogenesis and Treatment of Liver Disease in Transaldolase Deficiency
    Andras Perl; Fiscal Year: 2013
    ..HCC was the leading cause of death in both TAL+/- (39/229;17%) and TAL-/- mice (45/97;46%) as compared to TAL+/+ littermates (1/102;1%)...
  9. Soluble Epoxide Hydrolase as a Target for Ischemic Cardioprotection
    Donna M Van Winkle; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Heart disease is the leading cause of death in men and women...
  10. Genetic and physiological causes of inherited Vascular and Metabolic Diseases
    Arya Mani; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Coronary artery disease (CAD) and its consequences are the single largest cause of death in the United States. CAD risk factors include high blood pressure, high cholesterol and diabetes...
  11. Insulin Signaling and the Heart in Diabetes
    EVAN DALE ABEL; Fiscal Year: 2011
    ..PUBLIC HEALTH RELEVANCE: Heart disease remains the leading cause of death in individuals with diabetes...
  12. Regulation of myocardial growth and death by GSK-3
    Junichi Sadoshima; Fiscal Year: 2013
    ..The knowledge obtained from this investigation should be useful for the development of better treatment for heart failure, ischemic injury and stem cell therapy. ..
  13. Phage Display for Improved Peptide-based Tumor Targeting and Imaging Agents
    Susan L Deutscher; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cancer is the second leading cause of death in the United States and US Veterans. Over 28% of cancer diagnoses in US Veterans in 2009 were for prostate, breast, and ovarian carcinoma...
  14. Molecular mechanisms of lung disease in ataxia telangiectasia
    JoAnn M Sekiguchi; Fiscal Year: 2013
    ..Despite the prevalence of ILD as a cause of death in A-T patients, the underlying mechanisms that lead to this phenotype are not well understood...
  15. Efficacy of Yoga for Treatment-Resistant PTSD
    Bessel Van der Kolk; Fiscal Year: 2010
    ..F., Spitz, A.M., Edwards, V., et al. (1997). Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults: The Adverse Childhood Experiences (ACE) Study. Am J Preventive Med, 14, 245-258. ..
  16. Molecular Mechanism of Protein Kinase Cbeta-Mediated Cholesterol Homeostasis
    Kamal D Mehta; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: Cardiovascular disease remains the leading cause of death in industrialized nations despite major advances in its diagnosis, treatment, and prevention...
  17. The Role of Interleukin-10 During Fatal Alphavirus Encephalomyelitis
    KIRSTEN KULCSAR; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Encephalitic arthropod-borne viruses are emerging as a major cause of death and disease worldwide...
  18. Intrathoracic Pressure Regulator for Resuscitation
    Keith G Lurie; Fiscal Year: 2011
    ..treatment of patients with life-threatening hypotension from traumatic injuries, trauma remains the number one cause of death among Americans between the ages of 1 and 44 and the fourth leading cause of death overall...
  19. Clinical Development of Hemostatic Agent ClotFoam for Severe Hemorrhage
    Maja Nowakowski; Fiscal Year: 2013
    ..Hemorrhage, resulting from traumatic injuries, is a major cause of death in accidents, and the primary cause of death on the battlefield...
  20. The mechanisms by which alcohol and HIV render the lung susceptible to injury
    DAVID MARSHALL GUIDOT; Fiscal Year: 2013
    ..This research project is designed to determine how alcohol and HIV-1 interact to make the lung susceptible to injury, and to develop effective treatments that can improve the health of these vulnerable individuals. ..
  21. Mitochondrial and Nuclear Mechanisms of Estrogen Receptor-Mediated Cardioprotecti
    DONNA HOPE KORZICK; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: The leading cause of death among persons aged 75 years or older is heart disease, and deaths due to heart disease have actually increased ..
  22. Alcohol, Proteasome Dysfunction in Liver Injury
    Craig J McClain; Fiscal Year: 2013
    ..Potential Impact on Veterans Health: Alcoholic liver disease is a leading cause of death from liver disease in the United States and in the Veterans Administration...
  23. Transplacental Arsenic Induced Hepatic Dysfunction and Vascular Disease
    J Christopher States; Fiscal Year: 2010
    Cardiovascular disease is the major cause of death in the U.S. Chronic arsenic ingestion causes atherosclerosis and is associated with increased mortality from myocardial infarction and stroke...
  24. Pilot Studies of the Effect of Aging on Mucociliary Clearance
    Lawrence E Ostrowski; Fiscal Year: 2013
    ..In this population, pneumonia is the leading cause of death due to infectious disease, and the incidence of community-acquired pneumonia increases with every decade of ..
  25. Regulation of vaccine-induced anti-fungal T17 cells
    MARCEL WUETHRICH; Fiscal Year: 2013
    ..In this proposal, we will identify the host-pathogen interactions that are the foundation of vaccine-induced resistance. The knowledge gained from this research will lead to the development of fungal vaccines and adjuvants. ..
  26. Roles of NF-kB/Rel in the pathogenesis of breast cancer
    Gail E Sonenshein; Fiscal Year: 2012
    ..applicant): Breast cancer incidence has been increasing over the past 50 years, and is now the second leading cause of death among American women...
  27. Role of TPH2 and 5HT Neuronal Loss in Non-motor Symptoms of Parkinson's
    Donald M Kuhn; Fiscal Year: 2012
    ..PD is the seventh leading cause of death in the US...
  28. Epidemiology and Etiology of Hospitalized Pneumonia in Children
    Krow Ampofo; Fiscal Year: 2010
    Pneumonia in children is a major cause of morbidity and mortality worldwide and the leading cause of death in children younger than 5 years of age worldwide...
  29. Development of a Porcine Model of Atherosclerosis
    Christopher Rogers; Fiscal Year: 2010
    ..by applicant): Atherosclerosis is the primary cause of cardiovascular disease, which is the most common cause of death in the United States...
  30. Development and Validation of an Instrument to Assess Cognitive Function Regulati
    Xi Chen; Fiscal Year: 2013
    ..All of these are essential to achieving my long-term goal of developing a new evidence-based model of dementia dental care. ..
  31. Lung VITamin D and OmegA-3 TriaL (Lung VITAL)
    Diane R Gold; Fiscal Year: 2013
    ..If vitamin D or marine omega-3 fatty acid supplementation reduce COPD and asthma exacerbations, reduce decline of lung function, improve asthma control and/or reduce pneumonia risk, this would be of great benefit to public health. ..
  32. Neuropilin and semaphorin, anti-angiogenesis activities and mechanisms
    Michael Klagsbrun; Fiscal Year: 2009
    Abstract Cancer is a major cause of death in the U.S...
  33. The Role of Alcohol in HIV Therapy Hepatotoxicity
    Craig J McClain; Fiscal Year: 2012
    ..Liver disease is now a leading cause of death for patients with HIV...
  34. Androgen Receptor Pathway and Risk of Hepatic Fibrosis in Hepatitis C
    DONNA LORRAINE WHITE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cirrhosis or highly advanced fibrosis is the 13th leading cause of death in the U.S. The leading cause of cirrhosis is the hepatitis C virus infection which affects more than 4 million Americans...
  35. DlaT as a transcriptional regulator in non-replicating Mycobacterium tuberculosis
    Ruslana Bryk; Fiscal Year: 2012
    ..tuberculosis (Mtb) latently infects one third of the world's population and remains a leading cause of death from a single bacterial infection worldwide...
  36. NOVEL PET AGENT FOR MYOCARDIAL PERFUSION IMAGING
    Vijay Sharma; Fiscal Year: 2013
    ..Successful execution of the outlined objectives should provide a molecular-targeted 68Ga-PET agent for MPI and management of CAD. ..
  37. Role of Vimentin in Pathogenesis of CNS Inflammation
    Sheng He Huang; Fiscal Year: 2013
    ..plays an important role in the pathogenesis of neonatal sepsis and meningitis (NSM), which remains a major cause of death in newborns, especially in low-birth weight infants...
  38. Effects of spinal cord injury on vagal afferents from the rat bladder and colon.
    April N Herrity; Fiscal Year: 2013
    ..In previous years, the leading cause of death in SCI patients was due to renal failure 76...
  39. Regulation of vasculature by estrogen receptors during aging in mouse models
    Margaret Markiewicz; Fiscal Year: 2013
    ..published data have shown that cardiovascular and cerebrovascular diseases were the first and third leading cause of death for those of age >65 respectively (Morbidity &Mortality: 2007 Chart Book NHLBI)...
  40. Biofilm Infections in Postsurgical, Trauma, and Critically Ill Patients
    Carol L Wells; Fiscal Year: 2013
    ..This project has the potential to fundamentally change our understanding of the initiation, development, and treatment of biofilm infections. ..
  41. MOLECULAR BIOLOGY OF HEMORRHAGIC SHOCK
    Timothy R Billiar; Fiscal Year: 2013
    Trauma is the leading cause of death in this country in people under the age of 54 years...
  42. Development of a Porcine Model of Atherosclerosis
    Christopher Rogers; Fiscal Year: 2012
    ..by applicant): Atherosclerosis is the primary cause of cardiovascular disease, which is the most common cause of death in the United States...
  43. Mitochondrial Mechanisms of Programmed Necrosis in the Aged Female Heart
    Alexandra M Machikas; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Acute myocardial infarction (AMI) is the leading cause of death among aged Americans, with increased mortality in postmenopausal women compared to age-matched men...
  44. Metabolic Dysfunction and Neuroprotection after Pediatric Head Injury
    Susanna Scafidi; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: TBI is a leading cause of death and long-term disability in children in United States...
  45. Regulation of Cardiac Kv Channel Expression
    Edwin S Levitan; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Heart failure, a leading cause of death, is associated with signaling that leads to poor cardiac pumping and arrhythmias that can induce sudden death...
  46. Mechanisms and Consequences of Intermittent Hypoxia-Induced Lipolysis
    Jonathan C Jun; Fiscal Year: 2013
    ..Potentially, devastating cardiovascular consequences of OSA may be averted by recognizing and preventing IH-induced lipolysis. ..
  47. Green Tea and Reduction of Breast Cancer Risk
    MINDY SUSAN KURZER; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Breast cancer is a leading cause of death in Western countries and incidence is increasing in Asia...
  48. Balance of Angiotensin II/Angiotensin (1-1): A Target in Ischemic Stroke
    Yanfang Chen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Ischemic stroke is the third leading cause of death in the United States. There are limited avenues for reducing cerebral damage and promoting repair after ischemic stroke...
  49. Cyclic AMP, Cytokine Modulation and Alcoholic Liver Disease
    Craig J McClain; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Alcoholic Liver Disease (ALD) remains a leading cause of death from liver disease in the U.S. and there is still no FDA-approved therapy...
  50. Therapeutic use of small-molecule HGF-mimetic for emphysema
    BERT J W M OEHLEN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Emphysema is a major cause of death and disability and afflicts approximately 2 million people. The disease cost more than $2...
  51. Experimental COPD: remediation, mitigation
    DONALD JOHN MASSARO; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE. Chronic obstructive pulmonary disease (COPD) is the 5th most common cause of death in industrialized nations, and is predicted to rise to 3rd most common by 2020...
  52. Role of ciliary proteins in endothelial cells morphogenesis
    Carlo Iomini; Fiscal Year: 2010
    ..In addition, although the kidney manifestation results in a gradual decline in renal function, the leading cause of death in patients with ADPKD is due to cardiovascular complications such as hypertension, aneurysm, and hemorrhage ..
  53. The RAGE of COPD
    John R Hoidal; Fiscal Year: 2013
    ..It is among the most common discharge diagnoses from VA hospitals and will be the third leading cause of death worldwide by the year 2020...
  54. A Novel Drug for Septicemia Targets A1 ARs
    Constance Neely Wilson; Fiscal Year: 2010
    ..In the U.S. sepsis is the 10th leading cause of death overall and accounts for over 750,000 cases and 215,000 deaths each year and $17 billion in annual health care ..
  55. Amoeboid Membrane Dynamics in Prostate Cancer
    Michael R Freeman; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Prostate adenocarcinoma (PCa) is a leading cause of death from cancer and there is no effective treatment for "castration-resistant" disease...
  56. Autoimmunity in the Mediation of Infectious Myocarditis
    Jay Reddy; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Heart disease is the leading cause of death in humans, and myocarditis is a predominant cause of heart failure in young adolescents...
  57. Mediators of Atherosclerosis in South Asians Living in America
    Alka M Kanaya; Fiscal Year: 2013
    ..that are linked to atherosclerosis will provide targets for future therapies to prevent or cure the leading cause of death worldwide - cardiovascular disease...
  58. Best Management of Sigmoid Volvulus: a Prospective Randomized Trial
    JONATHAN CHARLES SAMUEL; Fiscal Year: 2013
    ..Despite sigmoid volvulus being a frequent cause of death in many developing countries, only one prospective randomized trial has ever been conducted and this trial ..
  59. Gallstone Pancreatitis: Pathogenesis and Treatment
    Isaac Samuel; Fiscal Year: 2012
    ..Systemic spread of acute pancreatic inflammation leads to multi-organ failure which is the major cause of death from acute pancreatitis...
  60. Pulmonary Vascular-Right Ventricular Axis Research Program
    Wai Hong Wilson Tang; Fiscal Year: 2013
    ..by impaired regulation of pulmonary hemodynamics and vascular growth;right ventricular failure is the leading cause of death. Our studies have identified loss of pulmonary vascular endothelial nitric oxide synthase (eNOS) activity in ..
  61. Estradiol-Induced Sialyation Of NCAM Prevents Leucocyte:Endothelial Adhesion
    Frederick Naftolin; Fiscal Year: 2010
    ..Impact: Heart disease is the single greatest cause of death and results in staggering healthcare expenditures and personal suffering...
  62. A Novel Model of, and Pre-clinical Therapy for, Scleroderma Lung Disease
    Sergei P Atamas; Fiscal Year: 2012
    ..Interstitial lung disease - a combination of pulmonary inflammation and fibrosis - remains the main cause of death in patients with systemic sclerosis, or scleroderma...
  63. Intracavitary Hemostatic Agent for Non-compressible Hemorrhage
    Martin Bluth; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Hemorrhage resulting from traumatic injuries is a major cause of death in accidents, and the primary cause of death on the battlefield...
  64. Intrathoracic Pressure Regulation for the Treatment of Septic Shock
    Keith Lurie; Fiscal Year: 2009
    Despite advances in the treatment of patients with sepsis, sepsis remains the second most common cause of death in non-coronary intensive care units and the tenth leading cause of death overall in high-income countries...
  65. Drug-Eluting Bioresorbable Polymer Scaffolding for Treatment of Aortic Aneurysms
    Jack Griffis; Fiscal Year: 2009
    ..Aortic aneurysms affect as many as eight percent of people over the age of 65 and remains the 13th leading cause of death in the United States, accounting for more than 15,000 deaths each year...
  66. Micro-patterned surfaces for reducing the risk of catheter-associated UTI
    SHRAVANTHI REDDY; Fiscal Year: 2009
    ..Nosocomial infections are a leading cause of death in the U.S., and they result in major increases in hospital stays, human suffering, and healthcare costs...
  67. Self-Sensing Physiologic Control of a Rotary Mag Lev LVAD
    JAMES FARLEY WALTON; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Heart failure is the number one cause of death in the United States and presents an increasing public burden of morbidity and mortality even as the mortality from coronary artery disease and ..
  68. Bioactive Peptides for Mitigation of AGS and Acute Radiation Injury
    Lurong Zhang; Fiscal Year: 2010
    ..It would also reduce the overwhelming economic burden on health care system due to use the cheap and stable bioactive peptides rather than the expensive native proteins of growth factors. ..
  69. DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISK
    ERNST SCHAEFER; Fiscal Year: 2003
    Coronary heart disease (CHD) is a major cause of death and disability in our society. Obesity increases CHD risk by adversely affecting glucose, lipoproteins, and blood pressure...
  70. Pharmacogenetics of the Statin Response
    ERNST SCHAEFER; Fiscal Year: 2006
    Coronary heart disease (CHD) is the leading cause of death and disability in our society. Most CHD deaths occur in subjects over 70 years of age...
  71. Enhancing Clergy Suicide Prevention and Referral
    RICHARD CHARLES GOLDSWORTHY; Fiscal Year: 2010
    Suicide is the 2nd leading cause of death in persons aged 25-34, the 3rd leading cause of death among people in the age groups 10-14 and 15-24, and the 8th leading cause of male deaths...
  72. NAAG Peptidase Inhibitors for the Treatment of Traumatic Brain Injury
    Jia Zhou; Fiscal Year: 2009
    ..It is estimated that severe TBI will become the third most common cause of death and disability globally by the year 2020. An estimated 1...
  73. Cognitive and Neurologic Sequelae in Cerebral Malaria
    Chandy John; Fiscal Year: 2007
    ..Malaria is the leading cause of death in children under 5 years of age in Uganda...
  74. Domestic endotoxin exposure and chronic obstructive pulmonary disease
    Nadia Hansel; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States and is a progressive disease characterized by lung injury and inflammation...