Research Topics
Genomes and Genes
| cause of deathSummarySummary: Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint. Top Publications
Research Grants
| Scientific Experts
|
Detail Information
Publications
Global and regional burden of disease and risk factors, 2001: systematic analysis of population health dataAlan D Lopez
School of Population Health, University of Queensland, Brisbane 4006, Australia
Lancet 367:1747-57. 2006..Our aim was to calculate the global burden of disease and risk factors for 2001, to examine regional trends from 1990 to 2001, and to provide a starting point for the analysis of the Disease Control Priorities Project (DCPP)...
Projections of global mortality and burden of disease from 2002 to 2030Colin D Mathers
Evidence and Information for Policy Cluster, World Health Organization, Geneva, Switzerland
PLoS Med 3:e442. 2006..This paper describes the methods, assumptions, input data, and results...
Mortality associated with influenza and respiratory syncytial virus in the United StatesWilliam W Thompson
Influenza Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
JAMA 289:179-86. 2003..Influenza and respiratory syncytial virus (RSV) cause substantial morbidity and mortality. Statistical methods used to estimate deaths in the United States attributable to influenza have not accounted for RSV circulation...
Refining a probabilistic model for interpreting verbal autopsy dataPeter Byass
Umeå International School of Public Health, Umea University, Umea, Sweden
Scand J Public Health 34:26-31. 2006To build on the previously reported development of a Bayesian probabilistic model for interpreting verbal autopsy (VA) data, attempting to improve the model's performance in determining cause of death and to reassess it.
Risk of all-cause mortality associated with nonfatal AIDS and serious non-AIDS events among adults infected with HIVJacqueline Neuhaus
University of Minnesota, Minneapolis, Minnesota, USA
AIDS 24:697-706. 2010....
Validity of verbal autopsy procedures for determining cause of death in TanzaniaPhilip W Setel
Department of Epidemiology and MEASURE Evaluation, Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA
Trop Med Int Health 11:681-96. 2006..Verbal autopsy is an important method for deriving cause-specific mortality estimates where disease burdens are greatest and routine cause-specific mortality data do not exist...
Contribution of major diseases to disparities in mortalityMitchell D Wong
Division of General Internal Medicine and Health Services Research, University of California at Los Angeles, Los Angeles 90095 1736, USA
N Engl J Med 347:1585-92. 2002..Mortality from all causes is higher for persons with fewer years of education and for blacks, but it is unknown which diseases contribute most to these disparities...
No cry at birth: global estimates of intrapartum stillbirths and intrapartum-related neonatal deathsJoy Lawn
Saving Newborn Lives Save the Children, International Perinatal Care Unit, Institute of Child Health, London, England
Bull World Health Organ 83:409-17. 2005..7 to 1.2 million. Estimates for intrapartum stillbirths are not available. We aimed to estimate the numbers of intrapartum-related neonatal deaths and intrapartum stillbirths in the year 2000...
A 10 year study of the cause of death in children under 15 years in Manhiça, MozambiqueJahit Sacarlal
Centro de Investigação em Saúde da Manhiça CISM, Mozambique
BMC Public Health 9:67. 2009....
4 million neonatal deaths: when? Where? Why?Joy E Lawn
Saving Newborn Lives Save the Children USA, and International Perinatal Care Unit, Institute of Child Health, London, Cape Town, South Africa
Lancet 365:891-900. 2005..Low birthweight is an important indirect cause of death. Maternal complications in labour carry a high risk of neonatal death, and poverty is strongly associated with ..
Validation and application of verbal autopsies in a rural area of South AfricaK Kahn
Health Systems Development Unit, Department of Community Health, University of the Witwatersrand, Johannesburg, South Africa
Trop Med Int Health 5:824-31. 2000..To validate the causes of death determined with a single verbal autopsy instrument covering all age groups in the Agincourt subdistrict of rural South Africa...
Mortality due to systemic mycoses as a primary cause of death or in association with AIDS in Brazil: a review from 1996 to 2006Marli Prado
Departamento de Epidemiologia, Escola de Saúde Pública, Universidade de Sao Paulo, Sao Paulo, SP, Brasil
Mem Inst Oswaldo Cruz 104:513-21. 2009..When analysed as the underlying cause of death, paracoccidioidomycosis represented the most important cause of deaths among systemic mycoses (approximately ..
What you count is what you target: the implications of maternal death classification for tracking progress towards reducing maternal mortality in developing countriesSuzanne Cross
Immpact, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, Scotland
Bull World Health Organ 88:147-53. 2010..It is recommended that the potential effect of maternity services failing to take indirect maternal deaths into account should be modelled...
The Danish registers of causes of deathK Juel
Danish Institute for Clinical Epidemiology, Copenhagen
Dan Med Bull 46:354-7. 1999..This paper describes the history of the registers, the data sources and access to data, and the research based upon the registers, presenting some examples of research activities...
Counting the dead and what they died from: an assessment of the global status of cause of death dataColin D Mathers
Evidence and Information for Policy, World Health Organization, Geneva, Switzerland
Bull World Health Organ 83:171-7. 2005..We sought to assess the current status of global data on death registration and to examine several indicators of data completeness and quality...
Cause of death and presence of respiratory disease at autopsy in an HIV-1 seroconversion cohort of southern African gold minersJill Murray
National Institute for Occupational Health, PO Box 4788, Johannesburg2000, South Africa
AIDS 21:S97-S104. 2007..To describe causes of death and respiratory infections in HIV-infected miners in the pre-antiretroviral era, by duration of HIV infection...
Where and why are 10 million children dying every year?Robert E Black
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
Lancet 361:2226-34. 2003..A better understanding of child health epidemiology could contribute to more effective approaches to saving children's lives...
Setting international standards for verbal autopsyFrank Baiden
Bull World Health Organ 85:570-1. 2007
Causes of death among human immunodeficiency virus (HIV)-infected adults in the era of potent antiretroviral therapy: emerging role of hepatitis and cancers, persistent role of AIDSCharlotte Lewden
INSERM U593 (exU330, , 33076 Bordeaux Cedex, France
Int J Epidemiol 34:121-30. 2005..The prevention of non-AIDS related cancers, especially lung cancer, the management of non-Hodgkin's lymphoma, and of viral hepatitis are also important priorities...
Cancer survival in five continents: a worldwide population-based study (CONCORD)Michel P Coleman
Cancer Research UK Cancer Survival Group, Non communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London, UK
Lancet Oncol 9:730-56. 2008..This is, to our knowledge, the first worldwide analysis of cancer survival, with standard quality-control procedures and identical analytic methods for all datasets...
Procedural and 30-day outcomes following transcatheter aortic valve implantation using the third generation (18 Fr) corevalve revalving system: results from the multicentre, expanded evaluation registry 1-year following CE mark approvalNicolo Piazza
Thoraxcenter, Rotterdam, The Netherlands
EuroIntervention 4:242-9. 2008..To describe the procedural performance and 30-day outcomes following implantation using the 18 Fr CoreValve Revalving System (CRS) as part of the multicentre, expanded evaluation registry, 1-year after obtaining CE mark approval...
Marital status, educational level and household income explain part of the excess mortality of survey non-respondentsHanna Tolonen
National Institute for Health and Welfare, Helsinki, Finland
Eur J Epidemiol 25:69-76. 2010..the 1978 to 2002 surveys, including non-respondents, were linked with mortality data from the Finnish National Cause of Death statistics and with demographic and socio-economic register data (marital status, education and household ..
Impact of socioeconomic, behavioral and clinical risk factors on mortalityKimberly Rask
Rollins School of Public Health, Health Policy and Management, 1518 Clifton Road, Rm 636, Atlanta, GA 30322, USA
J Public Health (Oxf) 31:231-8. 2009..Efforts to reduce mortality will require a multi-faceted approach incorporating healthy behaviors and accessible health care systems in addition to clinical advances...
Clinical risk factors for mortality in patients with neurofibromatosis 1: a cohort study of 378 patientsKiarash Khosrotehrani
Department of Dermatology, , , , France
Arch Dermatol 139:187-91. 2003..Clinical follow-up should be focused on patients with subcutaneous neurofibromas and/or the absence of cutaneous neurofibromas and/or facial asymmetry...
Estimates of global mortality attributable to smoking in 2000Majid Ezzati
Department of Population and International Health, Harvard School of Public Health, Boston, MA 02115, USA
Lancet 362:847-52. 2003..Smoking is a risk factor for several diseases and has been increasing in many developing countries. Our aim was to estimate global and regional mortality in 2000 caused by smoking, including an analysis of uncertainty...
Newborn survival in low resource settings--are we delivering?J E Lawn
Saving Newborn Lives Save the Children USA, Cape Town 7405, South Africa
BJOG 116:49-59. 2009..There are promising models that have been tested mainly in research studies in Asia that are now being adapted and evaluated at scale including through a network of African implementation research trials...
The Accelerated Child Survival and Development programme in west Africa: a retrospective evaluationJennifer Bryce
Institute for International Programs, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Lancet 375:572-82. 2010..We undertook a retrospective evaluation of the programme in Benin, Ghana, and Mali...
Mortality differences according to living arrangementsSeppo Koskinen
National Public Health Institute, Department of Health and Functional Capacity, Helsinki, Finland
Int J Epidemiol 36:1255-64. 2007....
Cause-specific mortality and the extended effects of particulate pollution and temperature exposurePatrick G Goodman
School of Physics, Dublin Institute of Technology, and St James Hospital, Dublin, Ireland
Environ Health Perspect 112:179-85. 2004..This analysis suggests that studies on the acute effects of air pollution have underestimated the total effects of temperature and particulate air pollution on mortality...
Mortality among patients admitted to hospitals on weekends as compared with weekdaysC M Bell
Department of Medicine, University of Toronto, Sunnybrook and Women's College Health Sciences Centre, ON, Canada
N Engl J Med 345:663-8. 2001..CONCLUSIONS: Patients with some serious medical conditions are more likely to die in the hospital if they are admitted on a weekend than if they are admitted on a weekday...
Body mass index and mortality: results of a cohort of 184,697 adults in AustriaJochen Klenk
Institute of Epidemiology, University of Ulm, Helmholtzstrasse 22, 89081 Ulm, Germany
Eur J Epidemiol 24:83-91. 2009..Respiratory diseases contributed to mortality in the lowest BMI category independently from smoking status. Underweight and obesity were both associated with higher all-cause mortality in men and women...
Causes of deaths in children younger than 5 years in China in 2008Igor Rudan
Centre for Population Health Sciences, University of Edinburgh Medical School, Edinburgh, UK
Lancet 375:1083-9. 2010..We identified the main causes of deaths in neonates (<1 month), postneonatal infants (1-11 months), and children (<5 years) in China using information that was available to the public...
Inflammatory and coagulation biomarkers and mortality in patients with HIV infectionLewis H Kuller
University of Pittsburgh, Pittsburgh, Pennsylvania, USA
PLoS Med 5:e203. 2008..We hypothesized that increased HIV-RNA levels following ART interruption induced activation of tissue factor pathways, thrombosis, and fibrinolysis...
Effect of a multifactorial intervention on mortality in type 2 diabetesPeter Gaede
Steno Diabetes Center, Copenhagen, Denmark
N Engl J Med 358:580-91. 2008..We evaluated whether this approach would have an effect on the rates of death from any cause and from cardiovascular causes...
Comparisons of causes of death and mortality rates among HIV-infected persons: analysis of the pre-, early, and late HAART (highly active antiretroviral therapy) erasNancy F Crum
Infectious Diseases Division, Clinical Investigation Department, Naval Medical Center San Diego, San Diego, CA 92134 1005, USA
J Acquir Immune Defic Syndr 41:194-200. 2006..Comparisons of death-related variables during the 3 eras were performed...
Diseases of comfort: primary cause of death in the 22nd centuryBernard C K Choi
Centre for Chronic Disease Prevention and Control CCDPC, Public Health Agency of Canada PHAC, Government of Canada, AL no 6701A, 120 Colonnade Road, Ottawa, Ontario K1A 1B4, Canada
J Epidemiol Community Health 59:1030-4. 2005..If uncurbed, a new generation of "diseases of comfort" (such as those chronic diseases caused by obesity and physical inactivity) will become a major public health problem in this and the next century...
Changing mortality rates and causes of death for HIV-infected individuals living in Southern Alberta, Canada from 1984 to 2003H B Krentz
Southern Alberta Clinic, Calgary, Alberta, Canada
HIV Med 6:99-106. 2005..To examine changes over a 2-year period in both the mortality rate and the causes of death in a geographically defined HIV-infected population...
Evaluation of neonatal verbal autopsy using physician review versus algorithm-based cause-of-death assignment in rural NepalJames V Freeman
Department of Internal Medicine, Stanford University Medical Center, Stanford, CA, USA
Paediatr Perinat Epidemiol 19:323-31. 2005..We recommend an analysis technique that combines both methods, and further validation studies to improve performance of the VA for assigning causes of neonatal death...
WHO estimates of the causes of death in childrenJennifer Bryce
WHO, Geneva, Switzerland
Lancet 365:1147-52. 2005..The role of undernutrition as an underlying cause of death was estimated in collaboration with CHERG. FINDINGS: In 2000-03, six causes accounted for 73% of the 10...
Validity of verbal autopsy in determining causes of adult deathsR Kumar
Department of Community Medicine, PGIMER, Chandigarh
Indian J Public Health 50:90-4. 2006..The sensitivity and specificity of the cause of death assigned by physician from the verbal autopsy was calculated against the cause of death derived from the ..
Alcohol and Russian mortality: a continuing crisisDavid A Leon
London School of Hygiene and Tropical Medicine, London, UK and Max Planck Institute for Demographic Research, Rostock, Germany
Addiction 104:1630-6. 2009..In 2007, male life expectancy at birth was 61 years, while for females it was 74 years. Alcohol is implicated particularly in deaths among working-age men...
Tissue inhibitor of metalloproteinases levels in patients with chronic heart failure: an independent predictor of mortalityS Frantz
Department of Internal Medicine I, Center of Cardiovascular Medicine, University of Wurzburg, Wurzburg, Germany
Eur J Heart Fail 10:388-95. 2008..Matrix metalloproteinases (MMP) and their tissue inhibitors (TIMP) are involved in cardiac remodelling. The prognostic utility of TIMP is unknown in chronic heart failure (CHF)...
Do we really know the cause of death of the very old? Comparison between official mortality statistics and cohort study classificationAnnick Alperovitch
INSERM U708 Neuroepidemiology, Institut National de la Sante et de la Recherche Medicale, Hopital de la Salpetriere, 75651, Paris Cedex 13, France
Eur J Epidemiol 24:669-75. 2009..The former used all available data about the cause of death (hospital records, medical data obtained from family physicians or specialists, and proxy interviews) and the ..
Guidelines for reporting mortality and morbidity after cardiac valve interventionsCary W Akins
The American Association for Thoracic Surgery, Beverly, Massachusetts, USA
Ann Thorac Surg 85:1490-5. 2008
Mortality and cause of death in mucopolysaccharidosis type II-a historical review based on data from the Hunter Outcome Survey (HOS)S A Jones
Willink Unit, Genetic Medicine, Manchester Academic Health Science Centre, Central Manchester University Hospitals, NHS Foundation Trust, St Mary s Hospital, Manchester, UK
J Inherit Metab Dis 32:534-43. 2009..Data from patients who died after 1985 could serve as a control in analyses of the effects of enzyme replacement therapy with idursulfase on mortality in patients with MPS II...
Ecological association between a deprivation index and mortality in France over the period 1997 - 2001: variations with spatial scale, degree of urbanicity, age, gender and cause of deathGrégoire Rey
INSERM, CépiDc, IFR69, Le Vesinet, France
BMC Public Health 9:33. 2009..More specifically, the variations with the degree of urbanicity, spatial scale, age, gender and cause of death, which influence the association between mortality and deprivation, have been described.
Unexpected complications of transapical aortic valve implantationNawwar Al-Attar
Department of Cardiovascular Surgery, Bichat Claude Bernard Hospital, Paris, France
Ann Thorac Surg 88:90-4. 2009..However, specific problems of this new procedure are not well-described. Unexpected complications due to the procedure and their management are reported...
Aetiology of stillbirths and neonatal deaths in rural Ghana: implications for health programming in developing countriesKaren M Edmond
Kintampo Health Research Centre, Ghana Health Service, Kintampo, Brong Ahafo Region, Ghana
Paediatr Perinat Epidemiol 22:430-7. 2008In developing countries many stillbirths and neonatal deaths occur at home and cause of death is not recorded by national health information systems...
Validation of the symptom pattern method for analyzing verbal autopsy dataChristopher J L Murray
Institute for Health Metrics and Evaluation, University of Washington, Seattle, Washington, United States of America
PLoS Med 4:e327. 2007b>Cause of death data are a critical input to formulating good public health policy...
Causes of neonatal and child mortality in India: a nationally representative mortality surveyDiego G Bassani
Centre for Global Health Research, Li Ka Shing Knowledge Institute, St Michael s Hospital and Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5B 1W8, Canada
Lancet 376:1853-60. 2010..More than 2·3 million children died in India in 2005; however, the major causes of death have not been measured in the country. We investigated the causes of neonatal and child mortality in India and their differences by sex and region...
Mortality of Métis and registered Indian adults in Canada: an 11-year follow-up studyMichael Tjepkema
Health Analysis Division, Statistics, Canada
Health Rep 20:31-51. 2009..Little information has been published about the mortality of the Métis people of Canada. This study describes mortality patterns among Métis and Registered Indian adults, compared with the non-Aboriginal population...
The impact of marital status on cancer survivalO Kravdal
Department of Economics and Norwegian Cancer Registry, University of Oslo
Soc Sci Med 52:357-68. 2001..Other previously married have an excess mortality elevated by about 7%. This protective effect of marriage is not due to stage, which is controlled for. The possible importance of treatment and host factors is discussed...
Quality of cause of death certification at an academic hospital in Cape Town, South AfricaBeatrice Nojilana
Burden of Disease Research Unit, Medical Research Council Tygerberg, W Cape
S Afr Med J 99:648-52. 2009To investigate the quality of cause of death certification and assess the level of under-reporting of HIV/AIDS as a cause of death at an academic hospital.
Global and regional causes of deathColin D Mathers
Department of Health statistics and informatics, World Health Organization, 1211 Geneva, Switzerland
Br Med Bull 92:7-32. 2009..The paper also examines some of the data gaps, uncertainties and limitations in the resulting mortality estimates...
Suicide acts in 8 states: incidence and case fatality rates by demographics and methodR S Spicer
Pacific Institute for Research and Evaluation, Landover, MD 20785, USA
Am J Public Health 90:1885-91. 2000..This study examined incidence rates of medically identified suicide acts (self-inflicted injuries, either fatal or nonfatal) and case fatality rates by age, sex, race, and method used...
HIV mortality and infection in India: estimates from nationally representative mortality survey of 1.1 million homesPrabhat Jha
Centre for Global Health Research, Li Ka Shing Knowledge Institute, St Michael s Hospital, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada M5C1N8
BMJ 340:c621. 2010..To determine the rates of death and infection from HIV in India...
A prospective study of body mass index and mortality in BangladeshBrandon L Pierce
Department of Health Studies, The University of Chicago, Chicago, IL 60637, USA
Int J Epidemiol 39:1037-45. 2010..However, this relationship is not well characterized in Bangladesh, where the BMI distribution is shifted towards lower values...
Obesity and survival in patients with heart failure and preserved systolic function: a U-shaped relationshipJohn R Kapoor
Division of Cardiology, Stanford University, Palo Alto, CA 94305, USA
Am Heart J 159:75-80. 2010..However, it is unknown if this "obesity paradox" applies to heart failure patients with preserved EF or if it extends to the very obese (BMI >35)...
Causes of early childhood deaths in urban Dhaka, BangladeshAmal K Halder
Program on Infectious Diseases and Vaccine Science, International Center for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh
PLoS ONE 4:e8145. 2009..The child mortality in urban Dhaka was substantially lower than the national rate. Mortality rates were not affected by recall periods between 1 and 5 years...
Causes of death in HIV-infected women: persistent role of AIDS. The 'Mortalité 2000 & 2005' Surveys (ANRS EN19)Mojgan Hessamfar-Bonarek
INSERM, U897, Bordeaux, France
Int J Epidemiol 39:135-46. 2010..Little is known about the causes of death in human immunodeficiency virus (HIV)-infected women in the era of combination antiretroviral therapy (ART)...
Mortality in relation to smoking: 50 years' observations on male British doctorsRichard Doll
Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU, Radcliffe Infirmary, Oxford OX2 6HE
BMJ 328:1519. 2004..Among the men born around 1920, prolonged cigarette smoking from early adult life tripled age specific mortality rates, but cessation at age 50 halved the hazard, and cessation at age 30 avoided almost all of it...
Cause of death affects racial classification on death certificatesAndrew Noymer
Department of Sociology, University of California Irvine, Irvine, California, United States of America
PLoS ONE 6:e15812. 2011..This study examines whether cause of death influences racial classification on death certificates...
Age at menopause, cause-specific mortality and total life expectancyMarlies E Ossewaarde
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
Epidemiology 16:556-62. 2005..In particular, ischemic heart disease mortality is 2% lower. Although the risk of death from uterine or ovarian cancer is increased by 5%, the net effect of a later menopause is an increased lifespan...
Probability of liver cancer and survival in HCV-related or alcoholic-decompensated cirrhosis. A study of 377 patientsRicard Sola
Liver Section, Department of Gastroenterology, Hospital del Mar, Barcelona, Spain
Liver Int 26:62-72. 2006..Although chronic alcohol intake and chronic hepatitis C may progress to cirrhosis and hepatocellular carcinoma (HCC), few data are available about survival and probability of developing HCC in decompensated cirrhosis of both aetiologies...
Prognostic importance of secondary pulmonary hypertension after acute myocardial infarctionJacob E Møller
Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Am J Cardiol 96:199-203. 2005..22 per 10 mm Hg, p <0.0001), after adjustment for conventional risk factors and left ventricular function...
Prognostic factors and impact of treatment in melanoma brain metastases: better prognosis for women?Maja A Hofmann
Department of Dermatology and Allergy, Skin Cancer Centre, Charite Universitatsmedizin Berlin, Berlin, Germany
Dermatology 215:10-6. 2007..Brain metastases are a common consequence in patients with stage IV melanoma associated with a grim prognosis...
The effectiveness of beta-blockers after myocardial infarction in patients with type 2 diabetesCharlotte G McDonald
Department of Medicine, Division of Endocrinology, University of Western Ontario, London, Canada
Diabetes Care 28:2113-7. 2005..The purpose of this study was to determine the effectiveness of beta-blockers after MI in patients with type 2 diabetes...
Gender-related differences in the clinical presentation and outcome of hypertrophic cardiomyopathyIacopo Olivotto
Regional Referral Center for Myocardial Diseases, Azienda Ospedaliera Universitaria Careggi, Florence, Italy
J Am Coll Cardiol 46:480-7. 2005..The goal of this study was to assess gender-related differences in a multicenter population with hypertrophic cardiomyopathy (HCM)...
Risk factors for lethal outcome in patients with bullous pemphigoid: low serum albumin level, high dosage of glucocorticosteroids, and old ageBerthold Rzany
Department of Dermatology, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Mannheim, Germany
Arch Dermatol 138:903-8. 2002..Although bullous pemphigoid (BP) is the most frequent autoimmune bullous disease and is associated with a considerable case-fatality rate, little is known about factors that influence its prognosis...
Estimating late adverse events using competing risks after autologous stem-cell transplantation in aggressive non-Hodgkin lymphoma patientsRodrigo Ruiz-Soto
Departement of Medicine, Institut Gustave Roussy, Villejuif, France
Cancer 104:2735-42. 2005..CONCLUSION: ASCT is effective in patients with aggressive NHL with a poor prognosis. However, careful long-term follow-up of survivors is recommended because of the increase in malignant and nonmalignant toxicities...
Trends in educational and occupational differentials in all-cause mortality in Austria between 1981/82 and 1991/92Gabriele Doblhammer
Empirical Social Research, Department of Economics and Social Sciences, Faculty of Business Administration, University of Rostock, Rostock, Germany
Wien Klin Wochenschr 117:468-79. 2005..Their absolute mortality and relative mortality risks decreased faster than those of all other educational groups. Educational differentials among women remained unchanged...
Lymphovascular invasion is independently associated with overall survival, cause-specific survival, and local and distant recurrence in patients with negative lymph nodes at radical cystectomyYair Lotan
Department of Urology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9110, USA
J Clin Oncol 23:6533-9. 2005..We hypothesized that bladder cancer patients with associated lymphovascular invasion (LVI) are at increased risk of occult metastases...
Deaths occurring during the first year after treatment onset for polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome: a retrospective analysis of causes and factors predictive of mortality based on 595 patientsAnne Bourgarit
Department of Internal Medicine, , , France
Medicine (Baltimore) 84:323-30. 2005..Cyclophosphamide-induced cytopenia and infection were responsible for 2 deaths. Despite these iatrogenic complications, early deaths were more frequently the consequence of insufficient or inappropriate therapy...
Differential mortality and transplantation rates among Asians and Pacific Islanders with ESRDYoshio N Hall
Departments of Medicine, University of California San Francisco, San Francisco, CA 94118-1211, USA
J Am Soc Nephrol 16:3711-20. 2005..Strategies that are aimed at improving access to transplantation in Asian and Pacific Islander communities may further enhance survival among Asians and Pacific Islanders with ESRD...
Civilian craniocerebral gunshot wounds: an update in predicting outcomesTiffany Murano
Department of Surgery, Division of Emergency Medicine, UMDNJ-New Jersey Medical School, Newark, New Jersey 07103, USA
Am Surg 71:1009-14. 2005..This is not only important in determining treatment algorithms for physicians but also for appropriate counseling of family members to educate them with regard to patients' outcomes...
The incidence and impact of comorbidity diagnosed after the onset of head and neck cancerKatherine C Yung
Clinical Outcomes Research Office, Department of Otolaryngology Head and Neck Surgery, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
Arch Otolaryngol Head Neck Surg 134:1045-9. 2008..To investigate the incidence and prognostic impact of comorbidities diagnosed after the onset of head and neck cancer...
Risk factors profile for acute kidney injury after cardiac surgery is different according to the level of baseline renal functionRaul Lombardi
Department of Critical Care Medicine, IMPASA, Montevideo, Uruguay
Ren Fail 30:155-60. 2008..In addition to other well known risk factors for AKI in this setting, the use of diuretics in patients of group 1 and the level of hemodilution during CPB in both groups should be emphasized, as they are potentially modifiable...
Early care limitations independently predict mortality after intracerebral hemorrhageD B Zahuranec
Stroke Program, University of Michigan Medical School, Ann Arbor, MI 48109 0316, USA
Neurology 68:1651-7. 2007..Intracerebral hemorrhage (ICH) is associated with a high early mortality rate. We examined the impact of early do not resuscitate (DNR) orders and other limitations in aggressive care on mortality after ICH in a community-based study...
Survival of elderly persons undergoing colonoscopy: implications for colorectal cancer screening and surveillanceCharles J Kahi
Indiana University Medical Center, Roudebush Veterans Affairs Medical Center, Indiana University Department of Biostatistics, Indianapolis, Indiana 46202, USA
Gastrointest Endosc 66:544-50. 2007..In the elderly, the increased prevalence of colorectal neoplasia and the protective effect of colonoscopy may be offset by advancing age and comorbidity...
Risk factors for the incidence of breast cancer: do they affect survival from the disease?Gillian C Barnett
Oncology Centre, Box 193, Addenbrooke s Hospital, Hills Rd, Cambridge, CB2 2QQ, United Kingdom
J Clin Oncol 26:3310-6. 2008..Risk factors that influence the incidence of breast cancer may also affect survival after diagnosis...
Increased mortality in Dupuytren's diseaseO A Mikkelsen
Hospital for Rheumatic Diseases, Haugesund and Medstat, , Norway
J Hand Surg Br 24:515-8. 1999..In this age group men with Dupuytren's disease had 70% higher mortality than that of the control group. Disease duration did not seem to influence the mortality...
Survival with tiotropium compared to long-acting Beta-2-agonists in Chronic Obstructive Pulmonary DiseaseAndrea S Gershon
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
COPD 5:229-34. 2008..This result suggests that tiotropium might also be associated with decreased mortality compared to no treatment at all. Randomized placebo-control trials are needed to confirm these findings...
Hospital and long-term outcome after percutaneous endoscopic gastrostomyBrian M Smith
Department of Surgery, University of Toledo College of Medicine, Toledo, OH, USA
Surg Endosc 22:74-80. 2008..The objective of the study was to determine hospital and long-term survival in patients who receive PEG while hospitalized for medical or surgical reasons...
The impact of multiple metastatic nodal stations on survival in patients with resectable N1 and N2 nonsmall-cell lung cancerChang Hyun Kang
Department of Thoracic and Cardiovascular Surgery, Cancer Research Institute, Seoul National University Hospital, Seoul
Ann Thorac Surg 86:1092-7. 2008..The aim of the study was to identify common prognostic factors in nonsmall-cell lung cancer (NSCLC) with N1 and N2 nodal involvement...
Influence of diabetes mellitus on long-term survival in systematic off-pump coronary artery bypass surgeryBertrand Marcheix
Department of Cardiovascular Surgery, Montreal Heart Institute and Universite de Montreal, Montreal, Quebec
Ann Thorac Surg 86:1181-8. 2008..The aim of this study was to compare long-term results of OPCABG surgery for diabetic and nondiabetic patients...
Body mass index and outcome after ventricular assist device placementMichele Musci
Department of Cardiothoracic and Vascular Surgery, Deutsches Herzzentrum Berlin, Germany
Ann Thorac Surg 86:1236-42. 2008..Many patients with congestive heart failure develop cardiac cachexia. In this study the association between BMI and outcomes after VAD implantation was investigated...
The influence of surgery in MEN-1 syndrome: observations over 150 yearsStuart D Wilson
Endocrine Surgery Study Group, Department of Surgery, Medical College of Wisconsin and Froedtert Hospital, Milwaukee, WI 53226, USA
Surgery 144:695-701; discussion 701-2. 2008..This report utilizes a novel approach to evaluate the influence of evolving operative interventions for patients with MEN-1 syndrome...
Status epilepticus after stroke is associated with increased long-term case fatalitySusanne Knake
Department of Neurology, Interdisciplinary Epilepsy Center, University Hospital Giessen and Marburg, Marburg, Germany
Epilepsia 47:2020-6. 2006..04-4.32, p=0.0392]. CONCLUSIONS: The occurrence of SE in patients with cerebrovascular disease indicates a high risk of death within 3 years. In contrast, the case fatality risk attributable to recurrent status or seizures is lower...
Comparison of reduced-intensity and conventional myeloablative regimens for allogeneic transplantation in non-Hodgkin's lymphomaRoberto Rodriguez
Hematology and Hematopoietic Cell Transplantation, City of Hope Comprehensive Cancer Center, Duarte, California 91001, USA
Biol Blood Marrow Transplant 12:1326-34. 2006....
Calciphylaxis: natural history, risk factor analysis, and outcomeRoger H Weenig
Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA
J Am Acad Dermatol 56:569-79. 2007..Calciphylaxis is characterized by ischemic cutaneous ulceration, high mortality, and ineffective treatment...
Antipsychotic medication dispensing and risk of death in veterans and war widows 65 years and olderJean Hollis
School of Psychology, University of Sydney, Sydney, Australia
Am J Geriatr Psychiatry 15:932-41. 2007..To establish the instantaneous relative risk (RR) of death associated with individual antipsychotic drugs, carbamazepine and sodium valproate for those 65 years and older...
Biochemical failure as a determinant of distant metastasis and death in prostate cancer treated with radiotherapyAlan Pollack
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
Int J Radiat Oncol Biol Phys 57:19-23. 2003..However, little evidence is available to show that BF is associated with death for patents with prostate cancer treated with radiotherapy. We examined the relationship between BF and death from prostate cancer...
Clinical characteristics of and long-term outcome in Chinese patients with hypertrophic cardiomyopathyHee-Hwa Ho
Division of Cardiology, Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, China
Am J Med 116:19-23. 2004....
Serum uric acid levels show a 'J-shaped' association with all-cause mortality in haemodialysis patientsShih-Ping Hsu
Department of Internal Medicine, Far Eastern Memorial Hospital and National Taiwan University Hospital, Taipei, Taiwan, Republic of China
Nephrol Dial Transplant 19:457-62. 2004..CONCLUSIONS: These preliminary observations suggest that HD patients in the lowest and highest quintiles of UA levels would face higher risk of mortality. Further studies with larger sample sizes will be needed to confirm these findings...
Survival by time of day of hemodialysis: analysis of United States Renal Data System Dialysis Morbidity and Mortality Waves III/IVKevin C Abbott
Nephrology Service, Walter Reed Army Medical Center, Washington, DC 20307 5001, USA
Am J Kidney Dis 41:796-806. 2003..Whether morning shift hemodialysis is associated with improved survival in comparison to patients receiving afternoon shift hemodialysis has not been shown for a representative sample of US chronic hemodialysis patients...
Combined echocardiographic left ventricular hypertrophy and electrocardiographic ST depression improve prediction of mortality in American Indians: the Strong Heart StudyPeter M Okin
Division of Cardiology, Department of Medicine, Cornell Medical Center, 525 East 68th Street, New York, NY 10021, USA
Hypertension 43:769-74. 2004..These findings support the value of combining Echo-LVH and ECG-STD to improve risk stratification. These findings require verification in other populations...
Prognostic determinants in duodenal injuriesJason M Blocksom
Department of Surgery, Detroit Receiving Hospital, Wayne State University, Michigan 48201, USA
Am Surg 70:248-55; discussion 255. 2004....
Cancer incidence among Icelandic deck officers in a population-based studyPatrick Sulem
Department of Preventive Medicine, University of Iceland, Reykjavik, Iceland
Scand J Work Environ Health 29:100-5. 2003..11 for lung cancer CONCLUSIONS: An increased incidence of soft-tissue sarcoma was found among deck officers. This increase resembles that previously found for Swedish deck officers, and it warrants further study...
Validity of the Clock-Drawing Test as a screening tool for cognitive impairment in the elderlyYuji Nishiwaki
Centre for Ageing and Public Health, London School of Hygiene and Tropical Medicine, University of London, London, United Kingdom
Am J Epidemiol 160:797-807. 2004..The authors conclude that the CDT may have value as a brief face-to-face screening tool for moderate/severe cognitive impairment in an older community population but is relatively poor at detecting milder cognitive impairment...
Heart rate recovery and impact of myocardial revascularization on long-term mortalityMichael S Chen
Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Circulation 110:2851-7. 2004..HRR does not appear to identify patients likely to have a survival benefit...
Risk factors of mortality and permanent neurologic injury in patients undergoing ascending aortic and arch repairMartin Czerny
Department of Cardiothoracic Surgery, University of Vienna Medical School, Austria
J Thorac Cardiovasc Surg 126:1296-301. 2003..7%) underwent surgery requiring deep hypothermic circulatory arrest. Pre- and intraoperative factors were evaluated by means of stepwise logistic regression analysis to determine risk factors of mortality and permanent neurologic injury...
Research Grants
- Use of Beta-Lapachone for Lung Cancer ChemotherapyDavid Boothman; Fiscal Year: 2007Use of B-lapachone for non-small cell lung cancer (NSCLC) therapy Lung cancer is the leading cause of death by cancer in the U.S. Non-small cell lung cancer (NSCLC) comprises over 75% of lung cancers diagnosed...
- Use of Beta-Lapachone for Lung Cancer ChemotherapyDavid Boothman; Fiscal Year: 2007Use of B-lapachone for non-small cell lung cancer (NSCLC) therapy Lung cancer is the leading cause of death by cancer in the U.S. Non-small cell lung cancer (NSCLC) comprises over 75% of lung cancers diagnosed...
- Development and Validation of a Diagnostic Tool for Infant Head Injuries from FalSusan Margulies; Fiscal Year: 2009PROJECT ABSTRACT/SUMMARY Traumatic brain injury (TBI) is the most common cause of death in childhood. The predominant etiologies of TBI in young children are motor vehicle accidents, firearm incidents, falls, and child abuse...
- OLDER BREAST CANCER PATIENTS: RISK FOR COGNITIVE DECLINEJeanne Mandelblatt; Fiscal Year: 2009..PUBLIC HEALTH RELEVANCE: Cancer is the leading cause of death in the US and breast cancer is the second most common cancer among women in our country...
- Older Mothers and Adult Daughters: High Blood Pressure Self Management BehaviorsCeleste Shawler; Fiscal Year: 2009Heart disease is the leading cause of death in American women. Kentucky ranks as the 6 highest state in the nation for heart disease among women...
- Mechanisms of Programmed Gestational HyperphagiaMICHAEL GLENN ROSS; Fiscal Year: 2010..Obesity and its related diseases are the leading cause of death in western society, with associated risks of hypertension, coronary heart disease, stroke, diabetes, and ..
- Inhibition of HCV as an Opportunistic HIV Co-infectionJames C Fishbein; Fiscal Year: 2010..In a recent study exploring the cause of death in HIV patients, a majority of the dead had tested positive for antibodies to HCV...
- Inhibition of HCV as an Opportunistic HIV Co-infectionRAMACHANDRA HOSMANE; Fiscal Year: 2009..In a recent study exploring the cause of death in HIV patients, a majority of the dead had tested positive for antibodies to HCV...
- Role of Lipid Phosphatases in Cholesterol and Triglyceride SynthesisAndrew J Morris; Fiscal Year: 2010....
- Role of Lipid Phosphatases in Cholesterol and Triglyceride SynthesisAndrew J Morris; Fiscal Year: 2010....
- Overcoming Membrane Transporters to Improve CNS Drug TherapyRobert Clark; Fiscal Year: 2009..Notably, traumatic brain injury (TBI) remains the leading cause of death and disability amongst children and young adults...
- Biomarkers of toxic response to low nicotine cigarette smokeAndrew Strasser; Fiscal Year: 2010..Exposure to tobacco smoke (mainstream and environmental) is a leading cause of death in the US...
- Improved Drug Delivery to Tumors Using Novel Tissue Perfusion ApproachesLisa Coussens; Fiscal Year: 2009DESCRIPTION: Breast cancer is the most common cancer and second leading cause of death in women...
- Cardiopulmonary structure and function in Multi-Ethnic Study of AtherosclerosisR Graham Barr; Fiscal Year: 2010Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States. COPD will overtake stroke as the third leading cause of death within 7 years...
- DIETARY COMPOSITION, OBESITY, AND CARDIOVASCULAR RISKERNST SCHAEFER; Fiscal Year: 2003Coronary heart disease (CHD) is a major cause of death and disability in our society. Obesity increases CHD risk by adversely affecting glucose, lipoproteins, and blood pressure...
- Pharmacogenetics of the Statin ResponseERNST SCHAEFER; Fiscal Year: 2006Coronary heart disease (CHD) is the leading cause of death and disability in our society. Most CHD deaths occur in subjects over 70 years of age...
- Neutrophil Accumulation in Bacterial PneumoniaSamithamby Jeyaseelan; Fiscal Year: 2009Bacterial pneumonia is a leading cause of death. Recruitment of neutrophils into the lungs is one of the most important defense mechanisms in the initial host defense against bacterial infection...
- Neutrophil Accumulation in Bacterial PneumoniaSamithamby Jeyaseelan; Fiscal Year: 2009Bacterial pneumonia is a leading cause of death. Recruitment of neutrophils into the lungs is one of the most important defense mechanisms in the initial host defense against bacterial infection...
- Neutrophil Accumulation in Bacterial PneumoniaSamithamby Jeyaseelan; Fiscal Year: 2010Bacterial pneumonia is a leading cause of death. Recruitment of neutrophils into the lungs is one of the most important defense mechanisms in the initial host defense against bacterial infection...
- HIV and HIV/HCV-Infection, Disease Progression, Oxidative Stress and AntioxidantsMarianna Baum; Fiscal Year: 2007Co-infection with Hepatitis C (HCV) is becoming the main cause of death in HIV-infected patients in the United States. Among drug users the proportion of HIV/HCV co-infection is 50%-90%...
- HIV and HIV/HCV-Infection, Disease Progression, Oxidative Stress and AntioxidantsMarianna K Baum; Fiscal Year: 2010Co-infection with Hepatitis C (HCV) is becoming the main cause of death in HIV-infected patients in the United States. Among drug users the proportion of HIV/HCV co-infection is 50%-90%...
- Balance of Angiotensin II/Angiotensin (1-1): A Target in Ischemic StrokeYanfang Chen; Fiscal Year: 2010Ischemic stroke is the third leading cause of death in the United States. There are limited avenues for reducing cerebral damage and promoting repair after ischemic stroke...
- Education for Healthcare Providers of Alaska NativesAnne Lanier; Fiscal Year: 2007Cancer is now the leading cause of death for Alaska Natives (AN) surpassing trauma and infectious diseases that were the leading causes of death for many years. As recently as 1950,cancer was considered a rare disease in AN...
