incidence

Summary

Summary: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.

Top Publications

  1. ncbi Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
    J Tuomilehto
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    N Engl J Med 344:1343-50. 2001
  2. ncbi Global cancer statistics, 2002
    D Max Parkin
    Unit of Descriptive Epidemiology, International Agency for Research on Cancer, Lyon, France
    CA Cancer J Clin 55:74-108. 2005
  3. ncbi Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
    D C Angus
    Critical Care Medicine Division, Department of Anesthesiology and Critical Care Medicine, and the Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 29:1303-10. 2001
  4. doi Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012
    J Ferlay
    Section of Cancer Information, International Agency for Research on Cancer IARC, France
    Eur J Cancer 49:1374-403. 2013
  5. doi Incidence of 2009 pandemic influenza A H1N1 infection in England: a cross-sectional serological study
    Elizabeth Miller
    Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency Centre for Infections, London, UK
    Lancet 375:1100-8. 2010
  6. ncbi The epidemiology of sepsis in the United States from 1979 through 2000
    Greg S Martin
    Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Emory University School of Medicine, Atlanta, USA
    N Engl J Med 348:1546-54. 2003
  7. pmc Dengue and dengue hemorrhagic fever
    D J Gubler
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA
    Clin Microbiol Rev 11:480-96. 1998
  8. pmc Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    William C Knowler
    Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    N Engl J Med 346:393-403. 2002
  9. ncbi The growing burden of tuberculosis: global trends and interactions with the HIV epidemic
    Elizabeth L Corbett
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, England, UK
    Arch Intern Med 163:1009-21. 2003
  10. pmc Epidemiology and etiology of childhood pneumonia
    Igor Rudan
    Croatian Centre for Global Health, University of Split Medical School, Split, Croatia
    Bull World Health Organ 86:408-16. 2008

Detail Information

Publications284 found, 100 shown here

  1. ncbi Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
    J Tuomilehto
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    N Engl J Med 344:1343-50. 2001
    ..Whether type 2 diabetes can be prevented by interventions that affect the lifestyles of subjects at high risk for the disease is not known...
  2. ncbi Global cancer statistics, 2002
    D Max Parkin
    Unit of Descriptive Epidemiology, International Agency for Research on Cancer, Lyon, France
    CA Cancer J Clin 55:74-108. 2005
    Estimates of the worldwide incidence, mortality and prevalence of 26 cancers in the year 2002 are now available in the GLOBOCAN series of the International Agency for Research on Cancer...
  3. ncbi Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
    D C Angus
    Critical Care Medicine Division, Department of Anesthesiology and Critical Care Medicine, and the Center for Research on Health Care, University of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 29:1303-10. 2001
    To determine the incidence, cost, and outcome of severe sepsis in the United States.
  4. doi Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012
    J Ferlay
    Section of Cancer Information, International Agency for Research on Cancer IARC, France
    Eur J Cancer 49:1374-403. 2013
    Cancer incidence and mortality estimates for 25 cancers are presented for the 40 countries in the four United Nations-defined areas of Europe and for the European Union (EU-27) for 2012.
  5. doi Incidence of 2009 pandemic influenza A H1N1 infection in England: a cross-sectional serological study
    Elizabeth Miller
    Immunisation, Hepatitis and Blood Safety Department, Health Protection Agency Centre for Infections, London, UK
    Lancet 375:1100-8. 2010
    Knowledge of the age-specific prevalence of immunity from, and incidence of infection with, 2009 pandemic influenza A H1N1 virus is essential for modelling the future burden of disease and the effectiveness of interventions such as ..
  6. ncbi The epidemiology of sepsis in the United States from 1979 through 2000
    Greg S Martin
    Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Emory University School of Medicine, Atlanta, USA
    N Engl J Med 348:1546-54. 2003
    ..there is limited epidemiologic information about the demography of sepsis or about the temporal changes in its incidence and outcome...
  7. pmc Dengue and dengue hemorrhagic fever
    D J Gubler
    Division of Vector Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, Colorado 80522, USA
    Clin Microbiol Rev 11:480-96. 1998
    ..A major challenge for public health officials in all tropical areas of the world is to develop and implement sustainable prevention and control programs that will reverse the trend of emergent dengue hemorrhagic fever...
  8. pmc Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
    William C Knowler
    Diabetes Prevention Program Coordinating Center, Biostatistics Center, George Washington University, 6110 Executive Blvd, Suite 750, Rockville, MD 20852, USA
    N Engl J Med 346:393-403. 2002
    ..We hypothesized that modifying these factors with a lifestyle-intervention program or the administration of metformin would prevent or delay the development of diabetes...
  9. ncbi The growing burden of tuberculosis: global trends and interactions with the HIV epidemic
    Elizabeth L Corbett
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, England, UK
    Arch Intern Med 163:1009-21. 2003
    ..The increasing global burden of tuberculosis (TB) is linked to human immunodeficiency virus (HIV) infection...
  10. pmc Epidemiology and etiology of childhood pneumonia
    Igor Rudan
    Croatian Centre for Global Health, University of Split Medical School, Split, Croatia
    Bull World Health Organ 86:408-16. 2008
    Childhood pneumonia is the leading single cause of mortality in children aged less than 5 years. The incidence in this age group is estimated to be 0.29 episodes per child-year in developing and 0...
  11. ncbi Male circumcision for HIV prevention in men in Rakai, Uganda: a randomised trial
    Ronald H Gray
    Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD 21215, USA
    Lancet 369:657-66. 2007
    Ecological and observational studies suggest that male circumcision reduces the risk of HIV acquisition in men. Our aim was to investigate the effect of male circumcision on HIV incidence in men.
  12. ncbi Incidence and outcomes of acute lung injury
    Gordon D Rubenfeld
    Division of Pulmonary and Critical Care Medicine, Harborview Medical Center, Seattle, WA 98104 2499, USA
    N Engl J Med 353:1685-93. 2005
    ..Despite recent advances in our understanding of the mechanism and treatment of acute lung injury, its incidence and outcomes in the United States have been unclear.
  13. ncbi The diabetes risk score: a practical tool to predict type 2 diabetes risk
    Jaana Lindström
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Diabetes Care 26:725-31. 2003
    ..Interventions to prevent type 2 diabetes should be directed toward individuals at increased risk for the disease. To identify such individuals without laboratory tests, we developed the Diabetes Risk Score...
  14. pmc Estimated HIV incidence in the United States, 2006-2009
    Joseph Prejean
    Division of HIV AIDS Prevention, National Center for HIV, Viral Hepatitis, STD and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS ONE 6:e17502. 2011
    ..Previously, CDC estimated HIV incidence in the United States in 2006 as 56,300 (95% CI: 48,200-64,500)...
  15. doi Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study
    Christopher C Patterson
    Epidemiology Research Group, Centre for Public Health, Queen s University Belfast, Belfast, UK
    Lancet 373:2027-33. 2009
    The incidence of type 1 diabetes in children younger than 15 years is increasing. Prediction of future incidence of this disease will enable adequate fund allocation for delivery of care to be planned...
  16. ncbi Increasing incidence of thyroid cancer in the United States, 1973-2002
    Louise Davies
    VA Outcomes Group, Department of Veterans Affairs Medical Center, White River Junction, VT 05009, USA
    JAMA 295:2164-7. 2006
    Increasing cancer incidence is typically interpreted as an increase in the true occurrence of disease but may also reflect changing pathological criteria or increased diagnostic scrutiny...
  17. doi International variation in prostate cancer incidence and mortality rates
    Melissa M Center
    Intramural Research, American Cancer Society, Atlanta, GA 30303 1002, USA
    Eur Urol 61:1079-92. 2012
    ..Wide variation exists internationally for prostate cancer (PCa) rates due to differences in detection practices, treatment, and lifestyle and genetic factors...
  18. pmc Diabetes and cancer: a consensus report
    Edward Giovannucci
    Department of Nutrition, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes Care 33:1674-85. 2010
    Epidemiologic evidence suggests that cancer incidence is associated with diabetes as well as certain diabetes risk factors and diabetes treatments...
  19. ncbi Diabetes in Ontario: determination of prevalence and incidence using a validated administrative data algorithm
    Janet E Hux
    Institute for Clinical Evaluative Sciences, Toronto, Canada
    Diabetes Care 25:512-6. 2002
    ..We linked physician service claims (PSCs) and hospital discharge abstracts (HDAs) to determine diabetes prevalence and incidence.
  20. doi Global patterns of cancer incidence and mortality rates and trends
    Ahmedin Jemal
    Surveillance and Health Policy Research Department, American Cancer Society, 250 Williams Street Northwest, Atlanta, GA 30303 1002, USA
    Cancer Epidemiol Biomarkers Prev 19:1893-907. 2010
    While incidence and mortality rates for most cancers (including lung, colorectum, female breast, and prostate) are decreasing in the United States and many other western countries, they are increasing in several less developed and ..
  21. ncbi The incidence of congenital heart disease
    Julien I E Hoffman
    Department of Pediatrics and the Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    J Am Coll Cardiol 39:1890-900. 2002
    This study was designed to determine the reasons for the variability of the incidence of congenital heart disease (CHD), estimate its true value and provide data about the incidence of specific major forms of CHD...
  22. doi Effect of three decades of screening mammography on breast-cancer incidence
    Archie Bleyer
    Quality Department, St Charles Health System, Central Oregon, Portland, USA
    N Engl J Med 367:1998-2005. 2012
    ..Effective cancer-screening programs therefore both increase the incidence of cancer detected at an early stage and decrease the incidence of cancer presenting at a late stage.
  23. ncbi Gestational diabetes and the incidence of type 2 diabetes: a systematic review
    Catherine Kim
    Division of General Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    Diabetes Care 25:1862-8. 2002
    ..To examine factors associated with variation in the risk for type 2 diabetes in women with prior gestational diabetes mellitus (GDM)...
  24. ncbi An estimate of the worldwide prevalence and disability associated with osteoporotic fractures
    O Johnell
    Department of Orthopaedics, Malmo University Hospital, Malmo, Sweden
    Osteoporos Int 17:1726-33. 2006
    ..The aim of this study was to quantify the global burden of osteoporotic fracture worldwide...
  25. ncbi Rising incidence of hepatocellular carcinoma in the United States
    H B El-Serag
    Veterans Affairs Medical Center and the University of New Mexico, Albuquerque 87108, USA
    N Engl J Med 340:745-50. 1999
    ..data from the Surveillance, Epidemiology, and End Results (SEER) data base to determine the age-adjusted incidence of hepatocellular carcinoma from 1976 to 1995, data from the U.S...
  26. pmc The worldwide incidence of preterm birth: a systematic review of maternal mortality and morbidity
    Stacy Beck
    Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, USA
    Bull World Health Organ 88:31-8. 2010
    To analyse preterm birth rates worldwide to assess the incidence of this public health problem, map the regional distribution of preterm births and gain insight into existing assessment strategies.
  27. ncbi Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas
    Hiroko Ohgaki
    Pathology Group, International Agency for Research on Cancer HO, F 69372, Lyon, France
    J Neuropathol Exp Neurol 64:479-89. 2005
    ..This review summarizes data on incidence rates, survival, and genetic alterations from population-based studies of astrocytic and oligodendrogliomas that ..
  28. doi Prenatal and passive smoke exposure and incidence of asthma and wheeze: systematic review and meta-analysis
    Hannah Burke
    Division of Epidemiology and Public Health, University of Nottingham, City Hospital, UK Centre for Tobacco Control Studies, Nottingham, UK
    Pediatrics 129:735-44. 2012
    ..A systematic review and meta-analysis was conducted to provide estimates of the prospective effect of smoking by parents or household members on the risk of wheeze and asthma at different stages of childhood...
  29. doi Global epidemiology of oral and oropharyngeal cancer
    Saman Warnakulasuriya
    Department of Oral Medicine and Experimental Oral Pathology, King s College Dental Institute, Bessemer Road, London SE5 9RS, UK
    Oral Oncol 45:309-16. 2009
    This review presents data on incidence, mortality, survival and trends in cancers of the lip, oral cavity and oropharynx using available recent data sources around the world...
  30. pmc Estimating the global clinical burden of Plasmodium falciparum malaria in 2007
    Simon I Hay
    Spatial Ecology and Epidemiology Group, Department of Zoology, University of Oxford, Oxford, United Kingdom
    PLoS Med 7:e1000290. 2010
    ....
  31. doi Global epidemiology of meningococcal disease
    Lee H Harrison
    Infectious Diseases Epidemiology Research Unit, University of Pittsburgh School of Medicine and Graduate School of Public Health, 521 Parran Hall, 130 DeSoto Street, Pittsburgh, PA 15261, United States
    Vaccine 27:B51-63. 2009
    ..By far the highest incidence of meningococcal disease occurs in the meningitis belt of sub-Saharan Africa...
  32. ncbi A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality
    Vivian G Loo
    Department of Microbiology, McGill University Health Center, Montreal, Que, Canada
    N Engl J Med 353:2442-9. 2005
    In March 2003, several hospitals in Quebec, Canada, noted a marked increase in the incidence of Clostridium difficile-associated diarrhea.
  33. ncbi ACC/AHA/ESC 2006 Guidelines for the Management of Patients with Atrial Fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice
    Valentin Fuster
    Circulation 114:e257-354. 2006
  34. ncbi Permutation tests for joinpoint regression with applications to cancer rates
    H J Kim
    Syracuse University, Department of Mathematics, 215 Carnegie Building, Syracuse University, Syracuse, NY 13244 1150, USA
    Stat Med 19:335-51. 2000
    The identification of changes in the recent trend is an important issue in the analysis of cancer mortality and incidence data...
  35. pmc Cancer incidence and mortality in relation to body mass index in the Million Women Study: cohort study
    Gillian K Reeves
    Cancer Epidemiology Unit, University of Oxford, Oxford OX3 7LF
    BMJ 335:1134. 2007
    To examine the relation between body mass index (kg/m2) and cancer incidence and mortality.
  36. doi Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE)
    Ole Raaschou-Nielsen
    Danish Cancer Society Research Center, Copenhagen, Denmark
    Lancet Oncol 14:813-22. 2013
    Ambient air pollution is suspected to cause lung cancer. We aimed to assess the association between long-term exposure to ambient air pollution and lung cancer incidence in European populations.
  37. pmc Malaria in Brazil: an overview
    Joseli Oliveira-Ferreira
    Laboratório de Pesquisa em Malária, Instituto Oswaldo Cruz, FIOCRUZ, Pavilhão Leônidas Deane 5 degrees andar, Av Brasil 4365, Manguinhos, Rio de Janeiro, RJ CEP 21 045 900, RJ Brazil
    Malar J 9:115. 2010
    ..Although the main mosquito vector (Anopheles darlingi) is present in about 80% of the country, currently the incidence of malaria in Brazil is almost exclusively (99,8% of the cases) restricted to the region of the Amazon Basin, ..
  38. ncbi Decline in the AIDS and death rates in the EuroSIDA study: an observational study
    A Mocroft
    Royal Free Centre for HIV Medicine and Department of Primary Care and Population Sciences, Royal Free and University College Medical School, London, UK
    Lancet 362:22-9. 2003
    ..Since the introduction of highly active antiretroviral therapy (HAART), little is known about whether changes in HIV-1 mortality and morbidity rates have been sustained. We aimed to assess possible changes in these rates across Europe...
  39. doi The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study
    Guangwei Li
    Department of Endocrinology, China Japan Friendship Hospital, Beijing, China
    Lancet 371:1783-9. 2008
    Intensive lifestyle interventions can reduce the incidence of type 2 diabetes in people with impaired glucose tolerance, but how long these benefits extend beyond the period of active intervention, and whether such interventions reduce ..
  40. pmc Human papillomavirus and rising oropharyngeal cancer incidence in the United States
    Anil K Chaturvedi
    National Cancer Institute, National Institutes of Health, 6120 Executive Blvd, EPS 7072, Rockville, MD 20852, USA
    J Clin Oncol 29:4294-301. 2011
    Recent increases in incidence and survival of oropharyngeal cancers in the United States have been attributed to human papillomavirus (HPV) infection, but empirical evidence is lacking.
  41. doi Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review
    Natalie A Molodecky
    Department of Medicine, University of Calgary, Calgary, Alberta, Canada
    Gastroenterology 142:46-54.e42; quiz e30. 2012
    We conducted a systematic review to determine changes in the worldwide incidence and prevalence of ulcerative colitis (UC) and Crohn's disease (CD) in different regions and with time.
  42. pmc Profile: The Kilifi Health and Demographic Surveillance System (KHDSS)
    J Anthony G Scott
    Kenya Medical Research Institute, Wellcome Trust Research Programme, Kilifi, Kenya
    Int J Epidemiol 41:650-7. 2012
    ..Linked surveillance was extended to KHDSS vaccine clinics in 2008. KHDSS data have been used to define the incidence of hospital presentation with childhood infectious diseases (e.g...
  43. pmc Cancer statistics in Korea: incidence, mortality and survival in 2006-2007
    Kyu Won Jung
    The Korea Central Cancer Registry, National Cancer Center, Goyang, Korea
    J Korean Med Sci 25:1113-21. 2010
    Cancer has been the leading cause of death in Korea. Korea is facing a very rapid change and increase in cancer incidence, which draws much attention in public health...
  44. doi Sustained reductions in invasive pneumococcal disease in the era of conjugate vaccine
    Tamara Pilishvili
    Division of Bacterial Diseases and Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    J Infect Dis 201:32-41. 2010
    Changes in invasive pneumococcal disease (IPD) incidence were evaluated after 7 years of 7-valent pneumococcal conjugate vaccine (PCV7) use in US children.
  45. pmc Air pollution and incidence of hypertension and diabetes mellitus in black women living in Los Angeles
    Patricia F Coogan
    Slone Epidemiology Center at Boston University, 1010 Commonwealth Ave, Boston, MA 02215, USA
    Circulation 125:767-72. 2012
    ..Preliminary epidemiological and clinical evidence suggests that air pollution may contribute to the development of hypertension and type 2 diabetes mellitus...
  46. ncbi Hepatocellular carcinoma in cirrhosis: incidence and risk factors
    Giovanna Fattovich
    Department of Gastroenterology, University of Verona, Verona, Italy
    Gastroenterology 127:S35-50. 2004
    ..Hepatitis C virus (HCV) infection is associated with the highest HCC incidence in persons with cirrhosis, occurring twice as commonly in Japan than in the West (5-year cumulative incidence, ..
  47. doi Incidence of human papillomavirus (HPV) positive tonsillar carcinoma in Stockholm, Sweden: an epidemic of viral-induced carcinoma?
    Anders Näsman
    Department of Oncology Pathology, Karolinska Institutet, Stockholm, Sweden
    Int J Cancer 125:362-6. 2009
    In the county of Stockholm, between 1970 and 2002, we have previously reported a 3-fold parallel increase in the incidence of tonsillar squamous cell carcinoma (SCC) and the proportion of human papillomavirus (HPV) positive tonsillar SCC...
  48. doi Incidence estimate of nonmelanoma skin cancer in the United States, 2006
    Howard W Rogers
    Advanced Dermatology, 111 Salem Turnpike, Norwich, CT 06360, USA
    Arch Dermatol 146:283-7. 2010
    To estimate the incidence of nonmelanoma skin cancer (NMSC) in the US population in 2006 and secondarily to indicate trends in numbers of procedures for skin cancer treatment.
  49. doi Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials
    Peter M Rothwell
    Stroke Prevention Research Unit, Nuffield Department of Clinical Neuroscience, University of Oxford, UK
    Lancet 379:1602-12. 2012
    ..However, the short-term effect is less certain, especially in women, effects on cancer incidence are largely unknown, and the time course of risk and benefit in primary prevention is unclear...
  50. pmc Longitudinal study of infectious intestinal disease in the UK (IID2 study): incidence in the community and presenting to general practice
    Clarence C Tam
    Department of Infectious Disease Epidemiology, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK
    Gut 61:69-77. 2012
    To estimate, overall and by organism, the incidence of infectious intestinal disease (IID) in the community, presenting to general practice (GP) and reported to national surveillance.
  51. ncbi Sugar-sweetened beverages, weight gain, and incidence of type 2 diabetes in young and middle-aged women
    Matthias B Schulze
    Department of Nutrition, Harvard School of Public Health, Boston, Mass, USA
    JAMA 292:927-34. 2004
    ....
  52. ncbi Obesity and the risk of heart failure
    Satish Kenchaiah
    Framingham Heart Study, Framingham, Mass 01702, USA
    N Engl J Med 347:305-13. 2002
    ..Extreme obesity is recognized to be a risk factor for heart failure. It is unclear whether overweight and lesser degrees of obesity also pose a risk...
  53. ncbi Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2
    Mary Claire King
    Departments of Medicine and Genome Sciences, University of Washington, Seattle, WA 98195, USA
    Science 302:643-6. 2003
    ..Lifetime risks of ovarian cancer were 54% for BRCA1 and 23% for BRCA2 mutation carriers. Physical exercise and lack of obesity in adolescence were associated with significantly delayed breast cancer onset...
  54. ncbi Primary liver cancer: worldwide incidence and trends
    F Xavier Bosch
    Epidemiology and Cancer Registration Unit, IDIBELL Institut Català d Oncologia, Avda Gran Via s n, Km 2 7 08907 L Hospitalet de Llobregat, Barcelona, Spain
    Gastroenterology 127:S5-S16. 2004
    ..Rates of liver cancer in men are typically 2 to 4 times higher than in women. The incidence of primary liver cancer is increasing in several developed countries, including the United States, and the ..
  55. ncbi Increasing incidence of colorectal cancer in Asia: implications for screening
    Joseph J Y Sung
    Institute of Digestive Diseases, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
    Lancet Oncol 6:871-6. 2005
    ..including China, Japan, South Korea, and Singapore, have experienced an increase of two to four times in the incidence of colorectal cancer during the past few decades...
  56. ncbi Bacteremia among children admitted to a rural hospital in Kenya
    James A Berkley
    Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    N Engl J Med 352:39-47. 2005
    ..We studied every acute pediatric admission to a rural district hospital in Kenya to examine the prevalence, incidence, types, and outcome of community-acquired bacteremia.
  57. pmc The relationship between anti-merozoite antibodies and incidence of Plasmodium falciparum malaria: A systematic review and meta-analysis
    Freya J I Fowkes
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    PLoS Med 7:e1000218. 2010
    ..However, published evidence of the protective effect of these antibodies is conflicting...
  58. doi Effect of continuous positive airway pressure on the incidence of hypertension and cardiovascular events in nonsleepy patients with obstructive sleep apnea: a randomized controlled trial
    Ferran Barbe
    Coordinator Centre, IRB Lleida, Lleida, Spain
    JAMA 307:2161-8. 2012
    ..However, its indication for all patients with sleep-disordered breathing, regardless of daytime symptoms, is unclear...
  59. ncbi The Indian Diabetes Prevention Programme shows that lifestyle modification and metformin prevent type 2 diabetes in Asian Indian subjects with impaired glucose tolerance (IDPP-1)
    A Ramachandran
    Diabetes Research Centre, M V Hospital for Diabetes, WHO Collaborating Centre for Research, Education and Training in Diabetes, Royapuram, Chennai, India
    Diabetologia 49:289-97. 2006
    ..In a prospective community-based study, we tested whether the progression to diabetes could be influenced by interventions in native Asian Indians with IGT who were younger, leaner and more insulin resistant than the above populations...
  60. ncbi Strategies for mitigating an influenza pandemic
    Neil M Ferguson
    Department of Infectious Disease Epidemiology, Faculty of Medicine, Imperial College London, St Mary s Campus, Norfolk Place, London W2 1PG, UK
    Nature 442:448-52. 2006
    ..Estimates of policy effectiveness will change if the characteristics of a future pandemic strain differ substantially from those seen in past pandemics...
  61. ncbi Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world
    Farin Kamangar
    Nutritional Epidemiology and Biostatistics Branches, Division of Cancer Epidemiology and Genetics, National Institutes of Health, Department of Health and Human Services, Rockville, MD 20852 7244, USA
    J Clin Oncol 24:2137-50. 2006
    Efforts to reduce global cancer disparities begin with an understanding of geographic patterns in cancer incidence, mortality, and prevalence...
  62. doi Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation
    Gregory Y H Lip
    University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Birmingham, UK
    Chest 137:263-72. 2010
    ..Thus, many potential risk factors have not been included...
  63. ncbi Effect of screening and adjuvant therapy on mortality from breast cancer
    Donald A Berry
    Department of Biostatistics and Applied Mathematics, M D Anderson Cancer Center, Houston, TX 77030, USA
    N Engl J Med 353:1784-92. 2005
    ..We used modeling techniques to assess the relative and absolute contributions of screening mammography and adjuvant treatment to the reduction in breast-cancer mortality in the United States from 1975 to 2000...
  64. pmc Efficacy of quadrivalent HPV vaccine against HPV Infection and disease in males
    Anna R Giuliano
    Risk Assessment, Detection, and Intervention Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    N Engl J Med 364:401-11. 2011
    ..We report on the safety of a quadrivalent vaccine (active against HPV types 6, 11, 16, and 18) and on its efficacy in preventing the development of external genital lesions and anogenital HPV infection in boys and men...
  65. ncbi Lifetime risk for development of atrial fibrillation: the Framingham Heart Study
    Donald M Lloyd-Jones
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University Feinberg School of Medicine, 680 N Lake Shore Drive, Suite 1102, Chicago, IL, 60611, USA
    Circulation 110:1042-6. 2004
    ..Atrial fibrillation (AF) is the most common cardiac dysrhythmia and a source of considerable morbidity and mortality, but lifetime risk for AF has not been estimated...
  66. pmc HIV treatment as prevention: systematic comparison of mathematical models of the potential impact of antiretroviral therapy on HIV incidence in South Africa
    Jeffrey W Eaton
    Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom
    PLoS Med 9:e1001245. 2012
    ..This study compares the predictions of several mathematical models simulating the same ART intervention programmes to determine the extent to which models agree about the epidemiological impact of expanded ART...
  67. pmc Antidiabetic therapies affect risk of pancreatic cancer
    Donghui Li
    Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Gastroenterology 137:482-8. 2009
    ..We investigated the effect of antidiabetic therapies on the risk of pancreatic cancer...
  68. ncbi Perinatal depression: a systematic review of prevalence and incidence
    Norma I Gavin
    RTI International, 3040 Cornwallis Road, PO Box 12194, Research Triangle Park, NC 27709 2194, USA
    Obstet Gynecol 106:1071-83. 2005
    We systematically review evidence on the prevalence and incidence of perinatal depression and compare these rates with those of depression in women at non-childbearing times.
  69. ncbi Clinical epidemiology of inflammatory bowel disease: Incidence, prevalence, and environmental influences
    Edward V Loftus
    Inflammatory Bowel Disease Clinic, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gastroenterology 126:1504-17. 2004
    Although the incidence and prevalence of ulcerative colitis and Crohn's disease are beginning to stabilize in high-incidence areas such as northern Europe and North America, they continue to rise in low-incidence areas such as southern ..
  70. ncbi Estimates of the cancer incidence and mortality in Europe in 2006
    J Ferlay
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Ann Oncol 18:581-92. 2007
    Monitoring the evolution of the cancer burden in Europe is of great value. Estimates of the cancer burden in Europe have been published for 2004 and estimates are now being presented for cancer incidence and mortality in Europe for 2006.
  71. ncbi Secular trends in incidence of atrial fibrillation in Olmsted County, Minnesota, 1980 to 2000, and implications on the projections for future prevalence
    Yoko Miyasaka
    Division of Cardiovascular Disease and Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Circulation 114:119-25. 2006
    Limited data exist on trends in incidence of atrial fibrillation (AF). We assessed the community-based trends in AF incidence for 1980 to 2000 and provided prevalence projections to 2050.
  72. pmc Quantifying the burden of disease: the technical basis for disability-adjusted life years
    C J Murray
    Harvard Center for Population and Development Studies, Cambridge, MA 02138
    Bull World Health Organ 72:429-45. 1994
    ..Assigned to each class is a severity weight between 0 and 1. Finally, a three percent discount rate is used in the calculation of DALYs. The formula for calculating DALYs based on these assumptions is provided...
  73. pmc Secular trends in the incidence of hip and other osteoporotic fractures
    C Cooper
    The MRC Lifecourse Epidemiology Unit, Southampton General Hospital, University of Southampton, Southampton SO16 6YD, UK
    Osteoporos Int 22:1277-88. 2011
    ..Substantial geographic variation has been noted in the incidence of hip fracture throughout the world, and estimates of recent incidence trends have varied widely...
  74. doi Induced abortion: incidence and trends worldwide from 1995 to 2008
    Gilda Sedgh
    Guttmacher Institute, New York, NY, USA
    Lancet 379:625-32. 2012
    Data of abortion incidence and trends are needed to monitor progress toward improvement of maternal health and access to family planning. To date, estimates of safe and unsafe abortion worldwide have only been made for 1995 and 2003.
  75. doi Assessment of baseline age-specific antibody prevalence and incidence of infection to novel influenza A/H1N1 2009
    P Hardelid
    Centre for Infections, Health Protection Agency, London, UK
    Health Technol Assess 14:115-92. 2010
    ..in the population of England prior to arrival of the pandemic strain virus in the UK and (2) the age-specific incidence of infection by month as the pandemic progressed by measuring increases in the proportion of individuals with ..
  76. doi Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates
    Katherine L O'Brien
    GAVI s PneumoADIP, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Lancet 374:893-902. 2009
    ..To support local and global policy decisions on pneumococcal disease prevention and treatment, we estimated country-specific incidence of serious cases and deaths in children younger than 5 years.
  77. pmc The global burden of typhoid fever
    John A Crump
    Foodborne and Diarrheal Diseases Branch, Division of Bacterial and Mycotic Diseases, National Center for Infectious Diseases, MS A 38, Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30333, USA
    Bull World Health Organ 82:346-53. 2004
    ..To use new data to make a revised estimate of the global burden of typhoid fever, an accurate understanding of which is necessary to guide public health decisions for disease control and prevention efforts...
  78. pmc The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis
    Daphne P Guh
    Centre for Health Evaluation and Outcome Sciences, St Paul s Hospital, BC, Canada
    BMC Public Health 9:88. 2009
    ..The primary objective of this study is to provide an estimate of the incidence of each co-morbidity related to obesity and overweight using a meta-analysis.
  79. pmc Global estimate of the incidence of clinical pneumonia among children under five years of age
    Igor Rudan
    Department of Medical Stastistics, Epidemiology and Medical Infomatics, School of Public Health Andrija Stampar, Zagreb, Croatia
    Bull World Health Organ 82:895-903. 2004
    ..In this paper we aim to estimate the worldwide incidence of clinical pneumonia in young children.
  80. pmc Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005
    Sean F Altekruse
    Division of Cancer Control and Population Sciences, and the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20892 8316, USA
    J Clin Oncol 27:1485-91. 2009
    Hepatocellular carcinoma (HCC) is the third leading cause of cancer mortality worldwide. Incidence rates are increasing in the United States...
  81. ncbi Fasting serum glucose level and cancer risk in Korean men and women
    Sun Ha Jee
    Department of Epidemiology and Health Promotion, Graduate School of Public Health, Yonsei University, Seoul, Korea
    JAMA 293:194-202. 2005
    ..Diabetes is a serious and costly disease that is becoming increasingly common in many countries. The role of diabetes as a cancer risk factor remains unclear...
  82. doi Future of cancer incidence in the United States: burdens upon an aging, changing nation
    Benjamin D Smith
    Radiation Oncology Flight, Wilford Hall Medical Center, Lackland Air Force Base, 2200 Bergquist Dr, Ste 1, TX 78236, USA
    J Clin Oncol 27:2758-65. 2009
    ..Although cancer incidence varies by age and race, the impact of demographic changes on cancer incidence has not been fully characterized...
  83. ncbi Selected major risk factors and global and regional burden of disease
    Majid Ezzati
    Risk, Resources and Environmental Management Division, Resources for the Future, Washington, DC, USA
    Lancet 360:1347-60. 2002
    ..Our aim was to estimate the contributions of selected major risk factors to global and regional burden of disease in a unified framework...
  84. doi Prostate cancer incidence and mortality trends in 37 European countries: an overview
    F Bray
    Cancer Information Section, International Agency for Research on Cancer, Lyon, France
    Eur J Cancer 46:3040-52. 2010
    Prostate cancer has emerged as the most frequent cancer amongst men in Europe, with incidence increasing rapidly over the past two decades...
  85. doi Identification of hot spots of malaria transmission for targeted malaria control
    Teun Bousema
    Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, United Kingdom
    J Infect Dis 201:1764-74. 2010
    ..This heterogeneity creates opportunities for targeted interventions but only if hot spots of malaria transmission can be easily identified...
  86. doi Global burden of respiratory infections due to seasonal influenza in young children: a systematic review and meta-analysis
    Harish Nair
    Centre for Population Health Sciences, Global Health Academy, The University of Edinburgh, Edinburgh, UK
    Lancet 378:1917-30. 2011
    ..We aimed to estimate the global incidence of and mortality from lower respiratory infections associated with influenza in children younger than 5 years.
  87. pmc Estimated global incidence of Japanese encephalitis: a systematic review
    Grant L Campbell
    Ross River Consulting, LaPorte, United States of America
    Bull World Health Organ 89:766-74, 774A-774E. 2011
    To update the estimated global incidence of Japanese encephalitis (JE) using recent data for the purpose of guiding prevention and control efforts.
  88. ncbi Rates of HIV-1 transmission per coital act, by stage of HIV-1 infection, in Rakai, Uganda
    Maria J Wawer
    Heilbrun Department of Population and Family Health, Columbia University Mailman School of Public Health, New York, New York 10032, USA
    J Infect Dis 191:1403-9. 2005
    ..We estimated rates of human immunodeficiency virus (HIV)-1 transmission per coital act in HIV-discordant couples by stage of infection in the index partner...
  89. ncbi The incidence and severity of adverse events affecting patients after discharge from the hospital
    Alan J Forster
    University of Ottawa, F654 1053 Carling Avenue, Ottawa, Ontario K1Y 4E9, Canada
    Ann Intern Med 138:161-7. 2003
    ..Studies of hospitalized patients identify safety as a significant problem, but few data are available regarding injuries occurring after discharge. Patients may be vulnerable during this transition period...
  90. ncbi Incidence and prevalence of idiopathic pulmonary fibrosis
    Ganesh Raghu
    University of Washington Medical Center, Seattle, WA 98195 6522, USA
    Am J Respir Crit Care Med 174:810-6. 2006
    ..Idiopathic pulmonary fibrosis is a chronic interstitial lung disease of unknown etiology; its epidemiology in the United States has not been well characterized...
  91. doi Estimates of cancer incidence and mortality in Europe in 2008
    J Ferlay
    International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 08, France
    Eur J Cancer 46:765-81. 2010
    ..the relevant information for 2008 is not generally available as yet, we used statistical models to estimate incidence and mortality data for 25 cancers in 40 European countries (grouped and individually) in 2008...
  92. pmc Forecast of dengue incidence using temperature and rainfall
    Yien Ling Hii
    Umeå Centre for Global Health Research, Epidemiology and Global Health, Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden
    PLoS Negl Trop Dis 6:e1908. 2012
    ..The aim of this study was to develop and validate a forecasting model that could predict dengue cases and provide timely early warning in Singapore...
  93. pmc Long-term colorectal-cancer incidence and mortality after lower endoscopy
    Reiko Nishihara
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA, USA
    N Engl J Med 369:1095-105. 2013
    ..Colonoscopy and sigmoidoscopy provide protection against colorectal cancer, but the magnitude and duration of protection, particularly against cancer of the proximal colon, remain uncertain...
  94. doi Cancer incidence and incidence rates in Japan in 2007: a study of 21 population-based cancer registries for the Monitoring of Cancer Incidence in Japan (MCIJ) project
    Ayako Matsuda
    Surveillance Division, Center for Cancer Control and Information Services, National Cancer Center, 5 1 1 Tsukiji, Chuo Ku, Tokyo, Japan
    Jpn J Clin Oncol 43:328-36. 2013
    The Japan Cancer Surveillance Research Group aimed to estimate the cancer incidence in Japan in 2007 based on data collected from 21 out of 33 population-based cancer registries as part of the Monitoring of Cancer Incidence in Japan (..
  95. pmc Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis
    Harish Nair
    Centre for Population Health Sciences, Global Health Academy, The University of Edinburgh, Edinburgh, UK
    Lancet 375:1545-55. 2010
    ..We aimed to estimate the global incidence of and mortality from episodes of acute lower respiratory infection (ALRI) due to RSV in children younger than 5 ..
  96. doi Worldwide burden of cervical cancer in 2008
    M Arbyn
    Unit of Cancer Epidemiology, Scientific Institute of Public Health, Brussels, Belgium
    Ann Oncol 22:2675-86. 2011
    ..Up-to-date and reliable data are needed to assess impact of existing preventive measures and to define priorities for the future...
  97. pmc Annual report to the nation on the status of cancer, 1975-2006, featuring colorectal cancer trends and impact of interventions (risk factors, screening, and treatment) to reduce future rates
    Brenda K Edwards
    Surveillance Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, Maryland 20892 8315, USA
    Cancer 116:544-73. 2010
    ..This year's report includes trends in colorectal cancer (CRC) incidence and death rates and highlights the use of microsimulation modeling as a tool for interpreting past trends and ..
  98. pmc Trends in tuberculosis incidence and their determinants in 134 countries
    C Dye
    Stop TB Department, World Health Organization, Geneva, Switzerland
    Bull World Health Organ 87:683-91. 2009
    To determine whether differences in national trends in tuberculosis incidence are attributable to the variable success of control programmes or to biological, social and economic factors.
  99. ncbi Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group
    D H O'Leary
    Department of Radiology, Tufts New England Medical Center, Boston, MA, USA
    N Engl J Med 340:14-22. 1999
    ..We studied the associations between the thickness of the carotid-artery intima and media and the incidence of new myocardial infarction or stroke in persons without clinical cardiovascular disease.
  100. pmc Relation between falciparum malaria and bacteraemia in Kenyan children: a population-based, case-control study and a longitudinal study
    J Anthony G Scott
    Kenya Medical Research Institute Wellcome Trust Research Programme, Kilifi, Kenya org
    Lancet 378:1316-23. 2011
    ..Many investigators have suggested that malaria infection predisposes individuals to bacteraemia. We tested this hypothesis with mendelian randomisation studies of children with the malaria-protective phenotype of sickle-cell trait (HbAS)...
  101. ncbi Solid cancer incidence in atomic bomb survivors: 1958-1998
    D L Preston
    Hirosoft International, Eureka, California, USA
    Radiat Res 168:1-64. 2007
    This is the second general report on radiation effects on the incidence of solid cancers (cancers other than malignancies of the blood or blood-forming organs) among members of the Life Span Study (LSS) cohort of Hiroshima and Nagasaki ..

Research Grants81

  1. Novel TIRF microscopy analyzing trafficking & signaling at the cell cortex
    Derek Toomre; Fiscal Year: 2009
    ..Consistent with the recovery act's goal, this funding will provide full-time summer employment for 4 undergraduate students and accelerate scientific achievement of the parent DP2 award...
  2. Chymase-Mediated MMP Activation in Ishemia Reperfusion Injury
    LOUIS JOSEPH DELL'ITALIA; Fiscal Year: 2013
    ..response to the onset of chest pain coupled with the widespread use of statins and other drugs have reversed the incidence of ST elevation/nonST elevation MI from 70%/30% in the early 1990's to 30%/70% today...
  3. Sutureless Laparoscopic Partial Nephrectomy Using Laser Tissue Welding: Preclinic
    Yasmin Wadia; Fiscal Year: 2013
    ..3% localized or 181493 patients. Although the overall incidence of RCC has been steadily increasing for the past two decades, in large part due to the increased application of ..
  4. Transcription factors regulating sensory gene expression and pain pathways
    Eric E Turner; Fiscal Year: 2011
    ..Veterans are especially susceptable to suffering and disability from pain syndromes because of the high incidence of past trauma from military service...
  5. NIEHS SUPPORT OF THE AHS COHORT STUDY AT NCI
    Charles Knott; Fiscal Year: 2010
    ..Analyses on cancer incidence and other chronic diseases is continuing and a number of manuscripts focusing on cancer incidence overall, ..
  6. THE AGRICULTURAL HEALTH STUDY - FIELD STATIONS
    Charles Lynch; Fiscal Year: 2010
    ..Analyses on cancer incidence and other chronic diseases is continuing and a number of manuscripts focusing on cancer incidence overall, ..
  7. The gastric X/A-like (ghrelin) cell: A peripheral regulator of food intake
    NILS WG LAMBRECHT; Fiscal Year: 2012
    ..type in the USA, and that the 158 medical facilities include over 5 million patients, strategies to reduce the incidence of obesity and cachexia related morbidity and mortality are likely to have a beneficial impact not only on ..
  8. Autonomic, Endothelial, and Inflammatory Correlates of Sleep Duration
    MERCEDES RENEE CARNETHON; Fiscal Year: 2012
    Short sleep duration (<6 hours/night) is associated with a higher prevalence and incidence of hypertension, diabetes, and overweight/obesity, all of which can contribute to coronary heart disease...
  9. Angiotensin Adrenergic Interactions in the Kidney
    Roland C Blantz; Fiscal Year: 2013
    ..requiring artificial kidney treatments or kidney transplantation, but also contributes greatly to the very high incidence of heart and circulatory disease...
  10. Targeting Galectin-3 with novel drugs for treatment of eczema
    Fu Tong Liu; Fiscal Year: 2010
    ..has increased two- to three-fold during the past three decades in industrialized countries, where the current incidence in children is estimated to be 15-20%...
  11. Development of a Nonpsychotropic Cannabinoid Agonist for the Treatment of Sclerod
    Robert B Zurier; Fiscal Year: 2012
    ..Available data, while variable, indicate an incidence in the United States of 9 t 19 cases /million/year, and prevalence rates ranging from 28 to 253 cases/million (2)..
  12. Optimized Growth Media to Detect Intracellular Bacteria Implicated in Chronic Dis
    PATRICIA MASCARELLI; Fiscal Year: 2011
    ..b>Incidence of different Bartonella species by regions due to the existence of chronic carriers and/or vectors should be ..
  13. Retinoid and Carotenoid Depletion in Patients at High-Risk for Liver Cancer
    Peter H Gann; Fiscal Year: 2010
    ..Due to the epidemic of hepatitis C in the 1960's-70's, incidence has increased;approximately 3...
  14. Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
    Mona Fouad; Fiscal Year: 2013
    ..Participants will be contacted annually to determine current health status. Follow up includes ascertainment of adverse medical outcomes, cancer incidence, cause of death, and mortality impact.
  15. Prostate, Lung, Colorectal and Ovarian (PLCO) Screening Trial
    BARBARA O'BRIEN; Fiscal Year: 2013
    ..Participants will be contacted annually to determine current health status. Follow up includes ascertainment of adverse medical outcomes, cancer incidence, cause of death, and mortality impact.
  16. Natural History and Prevention of Viral Hepatitis Among Alaska Natives
    BRIAN JAMES MCMAHON; Fiscal Year: 2013
    ..B immunization strategies for infants, children, adolescents and adults have significantly decreased the incidence and prevalence of acute and chronic hepatitis B infection...
  17. Reactive (AA)Amyloidosis
    Merrill D Benson; Fiscal Year: 2013
    ..Veterans with paraplegia often have chronic infections such as osteomyelitis and, therefore, have an increased incidence of AA amyloidosis...
  18. Soluble Epoxide Hydrolase as a Target for Ischemic Cardioprotection
    Donna M Van Winkle; Fiscal Year: 2012
    ..However, current demographics show a high incidence of obesity, hypertension, and diabetes in young adults that herald a large increase in heart disease and ..
  19. Development of VN/14-1 and Related Analogs for Breast Cancer Therapy
    VINCENT COLLINS OFUKA NJAR; Fiscal Year: 2013
    ..highlights the influence of vitamin A (retinol) and its active metabolite, all-trans retinoic acid (ATRA) on the incidence of breast and prostate cancers in humans...
  20. Impact of the P479L Variant in CPT1A on Infant Mortality in Alaska
    David M Koeller; Fiscal Year: 2011
    ..newborn screening by tandem mass spectrometry (MS/MS), which led to the identification of an unexpectedly high incidence of carnitine palmitoyltransferase 1A (CPT1A) deficiency, a rare disorder of fatty acid oxidation...
  21. Prospective studies of cancer etiology and prevention in Shanghai and Singapore
    Jian Min Yuan; Fiscal Year: 2013
    ..The findings of the proposed study will have great impact on reducing incidence and mortality of lung and liver cancers in humans.
  22. Metabolic Engineering of Bacteria for Cancer Immunotherapy by Gamma Delta T Cells
    Craig T Morita; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In the United States and throughout the world, cancer incidence and mortality has increased dramatically in both developed and developing nations. Cancer causes ~13% of human deaths with 7...
  23. Chronic nicotine and synaptic transmission in brainstem respiratory neurons
    RALPH FRANK FREGOSI; Fiscal Year: 2013
    ..provided by applicant): At least 20% of pregnant women smoke, and their offspring have a higher than normal incidence of impaired cardiac function, autonomic nervous system disorders, sleep disorders, delayed speech and central ..
  24. MOLECULAR BASIS OF INSULIN RESISTANCE
    Maureen J Charron; Fiscal Year: 2010
    The incidence of Type 2 diabetes mellitus (T2DM) and the Metabolic Syndrome has reached epidemic proportions. Human and rodent studies provide strong support for a genetic predisposition to these pathologies...
  25. A Hybrid Katp Channel Opener to Prevent Radiocontrast-Induced Nephropathy
    Kanneganti Murthy; Fiscal Year: 2012
    ..The high incidence of atherosclerosis in this population frequently necessitates angiographic procedures of the coronary and ..
  26. Mechanism of Bladder Overactivity in Pelvic Ischemia
    Kazem M Azadzoi; Fiscal Year: 2013
    ..The incidence of bladder overactivity and LUTS increases with age...
  27. VitC to Decrease Effects of Smoking in Pregnancy on Infant Lung Function-CCC-Lead
    CYNTHIA T MCEVOY; Fiscal Year: 2013
    ..function tests in infants born to smoking mothers who received vitamin C, and preliminary data showing a lower incidence of wheezing at 1 year of age in these infants...
  28. INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEM
    JERROLD MICHAEL OLEFSKY; Fiscal Year: 2013
    ..resistance and it is the epidemic of obesity in the United States which is driving the dramatically increasing incidence of Type 2 diabetes...
  29. Tat and CDK9 on gene expression alterations coupled to HIV-1 Associated Dementia
    Xavier Grana; Fiscal Year: 2010
    ..While HAART has diminished the incidence of HIV-1-associated dementia (HAD), milder forms of neurological disease persist...
  30. Chronic Sleep Restriction Increases Immunity to Autoantigen: Role of the SNS
    Arnold E Postlethwaite; Fiscal Year: 2010
    ..Our studies show that both the severity and the incidence of arthritis are significantly increased in mice chronically sleep-restricted compared to control litter mates ..
  31. Mitochondrial dysfunction, oxidative stress, and surgical acute kidney injury
    FREDERIC TREMAINE BILLINGS; Fiscal Year: 2013
    ..a trial testing the hypothesis that short-term high- dose perioperative atorvastatin treatment reduces the incidence of postoperative AKI in which 270 subjects have already been studied (PI: Billings)...
  32. Prevention of UV-induced carcinogenesis by cyanidin-3-glucoside
    Xianglin Shi; Fiscal Year: 2013
    ..of skin cancer by natural non-toxic compounds is suggested as an effective strategy to prevent the incidence of skin cancer...
  33. Role of Diabetes in Development of Renal Cell Carcinoma
    SAMY LEWIZ HABIB; Fiscal Year: 2013
    ..Eker rats harboring mutations in TSC2 develop spontaneous renal tumors at a very high incidence. We showed also that loss of function of the tumor suppressor gene, tuberous sclerosis complex 2 (TSC2), which ..
  34. Combination drug treatment to inhibit multiple cell death pathways after TBI
    ALAN IRA FADEN; Fiscal Year: 2010
    ..It has been reported that the combined incidence of fatal and hospitalized TBI among all age groups has a median annual incidence of 101 per 100,000...
  35. Bisphosphonates in the treatment of chronic kidney disease-mineral bone disease
    Sharon M Moe; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In patients with chronic kidney disease (CKD), there is an increased incidence of low bone mass and fractures and coronary artery calcification and cardiovascular mortality compared to the general ..
  36. Immune Mechanism of Rejection in Human Lung Allografts
    Thalachallour Mohanakumar; Fiscal Year: 2013
    ..This will result in a marked reduction in the incidence and severity of PGD which will lead to reduction in the proinflammatory cytokine surge, down regulation of both ..
  37. A MicroRNA Approach to Screen for Sporadic Colon Cancer Exfoliately in Human Stoo
    Farid E Ahmed; Fiscal Year: 2010
    ..CRC incidence has declined from about 60 per 100,000 in 1975 to ~ 50 per 100,000 in 2004, and the decrease in USA mortality ..
  38. Latin American Center for Malaria Research and Control
    SOCRATES HERRERA VALENCIA; Fiscal Year: 2013
    ..The studies proposed for aim 1 are directed to determine the real prevalence and incidence of malaria by considering both symptomatic and asymptomatic individuals living in seasonal areas in LA...
  39. Central Action of Brain-Derived Neurotrophic Factor in Male and Female Rats
    Haifei Shi; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: As the prevalence of overweight and obesity is rising, the incidence of type 2 diabetes, cardiovascular disease, and some types of cancer is increasing at a similar alarming rate...
  40. Twenty-second Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2010
    ..anemia (FA) is a rare hereditary disease characterized by bone marrow failure, developmental anomalies, a high incidence of myelodysplasia (MDS), acute non-lymphocytic leukemia (AML), solid tumors, and cellular hypersensitivity to ..
  41. MOLECULAR MECHANISMS OF COMPLEX MIXTURE TOXICITY
    Alvaro Puga; Fiscal Year: 2013
    ..translation of these epidemiological findings and, by identifying molecular targets useful to reduce disease incidence, will significantly contribute to the development of therapeutic and preventative measures...
  42. 24th Annual Fanconi Anemia Research Fund Scientific Symposium
    GROVER CARLTON BAGBY; Fiscal Year: 2012
    ..anemia (FA) is a rare hereditary disease characterized by bone marrow failure, developmental anomalies, high incidence of myelodysplasia (MDS), acute non-lymphocytic leukemia (AML), solid tumors, and cellular hypersensitivity to ..
  43. Lactoferrin Enhances Growth and Reduces Nosocomial Infection in Preterm Infants
    Karel Petrak; Fiscal Year: 2009
    ..The overall incidence of prospectively studied NIs in hospitalized neonates has been reported to be 10.8 NI/100 patients...
  44. Regulation of Innate and Adaptive Immunity in Human COPD and Emphysema
    Farrah Kheradmand; Fiscal Year: 2012
    ..Despite an overall decline in the smoking prevalence in the United States, smoking incidence remains higher in veterans when compared to the same age group in the general population...
  45. Iron-Induced Changes in Liver That Predispose to Malignancy
    Harriet C Isom; Fiscal Year: 2010
    ..Preventative strategies are highly important in reducing the incidence and death from HCC. HCC is a slow process that occurs in the setting of liver cell injury...
  46. Development of Vaccines against Clostridium difficile Infection
    SAUL R TZIPORI; Fiscal Year: 2013
    ..With the recent emergence of hypervirulent strains, the incidence of C...
  47. MOLECULAR MECHANISMS OF DIOXIN ACTION
    Alvaro Puga; Fiscal Year: 2013
    ..goal is to identify the mechanisms and causes of these cardiac diseases and to develop tools to prevent their incidence. The objective of these studies is to determine whether an association between genetic and environmental factors ..
  48. Expanding Vietnamese Community and Academic Infrastructure for Health Research
    Bang H Nguyen; Fiscal Year: 2010
    ..Potential impact in health of the example projects supported the infrastructure services are reducing incidence and mortality caused by obesity;diabetes;sexually transmitted diseases;late stage breast cancer diagnosis;breast,..
  49. Early Life Conditions, Survival, and Health: A Pedigree-Based Population Study
    Ken R Smith; Fiscal Year: 2013
    ..outcomes are age-specific all-cause and cause-specific mortality, co-morbidity risks, site-specific cancer incidence, and morbidity trajectories. Aim 2...
  50. Nitric Oxide Restoration &Heme Detoxification as Adjunctive Therapies for Cerebr
    LEONARDO JOSE DE MOURA CARVALHO; Fiscal Year: 2012
    ..Adjunctive therapies for CM capable of improving survival and decreasing incidence of sequelae are urgently needed...
  51. Effects of Standardized Aerobic Exercise-Training on Neurocognitive and Neurodege
    Thomas O Obisesan; Fiscal Year: 2010
    ..Given that AAs: i) have higher incidence and prevalence of AD than Caucasians, ii) have paucity of cross-sectional, and lack prospective data on the ..
  52. Effect of diet & commensal bacteria on diabetes outcome in NOD mouse
    Li Wen; Fiscal Year: 2010
    ..by environmental factors as a) there is a significant discordance in T1D outcome in identical twins and b) the incidence of T1D is much higher in the Western world...
  53. Transplatin: A Novel Agent to Mitigate Cisplatin Toxicity
    Vickram Ramkumar; Fiscal Year: 2013
    ..However, this drug produces dose-limiting side effects such as ototoxicity and nephrotoxicity. While the incidence of nephrotoxicity is reduced by hydrating the patients prior to cisplatin administration, ototoxicity remains a ..
  54. Diagnosis of Subglottic Stenosis and Edema in Neonates Using OCT
    Brian Wong; Fiscal Year: 2013
    ..Early diagnosis of disease onset may lead to reduction in the incidence of tracheostomy and other airway complications...
  55. Targeting Cell Death to Prevent Ventricular Remodeling and Heart Failure
    Abhinav Diwan; Fiscal Year: 2011
    ..RELEVANCE: Project Narrative Heart failure is a very common disease of the aging population, with the highest incidence and prevalence in the age group above 65, which is also the largest Veteran population group (more than 40%)...
  56. Role of Retroelements in Environmental Atherogenesis
    Kenneth S Ramos; Fiscal Year: 2010
    ..Recent studies have shown that the incidence of this disease is accelerated by environmental contaminants, but the genetic mechanisms that mediate this ..
  57. Mechanims of CNS Autonomic Regulation by EA
    John C Longhurst; Fiscal Year: 2013
    ..Although acupuncture may be a viable inexpensive alternative that has a very low incidence of side effects, physicians generally are reluctant to recommend this therapy because little data are available ..
  58. Disease chronicity in juvenile dermatomyositis (JDM): Epigenetic clues
    Lauren M Pachman; Fiscal Year: 2013
    ..This defined a high serum IFN-1 subgroup within JDM, which may contribute to the increased incidence of JDM in girls...
  59. Genistein and Prostate Cancer
    Rajvir Dahiya; Fiscal Year: 2010
    ..The rationale for this project is that Western men have a 5-6 fold higher incidence of prostate cancer than Asians...
  60. Inhibiting Mucosal HIV-1 Transmission by Host Cell RNA Interference
    Alexandra L Howell; Fiscal Year: 2013
    ..S. Veteran and active military population, and because of the increasing incidence of this disease in the U.S.
  61. Modifiers of Cyst Progression in Polycystic Kidney Disease
    Phillip Darwin Bell; Fiscal Year: 2013
    ..There are also cardiovascular effects including hypertension and stroke. For reasons that are not clear, the incidence of PKD reported in the VA population is nearly double of that found in the general non- VA population...
  62. Advanced Nitric Oxide Release Bactericidal Urinary Catheters
    Mark E Meyerhoff; Fiscal Year: 2013
    ..CAUTIs contribute to 0.5-0.7 million nosocomial hospital infections annually with a cumulative incidence of 3-6% per day of catheterization (50% at 10 days, >90% at 28 days, 100% long term) leading to complications ..
  63. Triazole hypersensitivity in Candida albicans
    Neeraj Chauhan; Fiscal Year: 2009
    There has been a steady increase in the incidence of fungal infections over the past few decades, primarily due to the AIDS pandemic...
  64. Safety and PK Study in Hepatic Impairment Patients
    Weizhong Cai; Fiscal Year: 2010
    ..are expected to triple over the next decade as a result of the hepatitis C epidemic and the growing incidence of liver disease associated with non-alcoholic steatohepatitis...
  65. Epidemiology and Etiology of Hospitalized Pneumonia in Children
    Krow Ampofo; Fiscal Year: 2010
    ..Although the burden of pneumonia in children is well appreciated, recent data on the incidence and etiology of pneumonia in children are few...
  66. Combined raman spectroscopy-optical tomagraphy for complete diagnosis of skin can
    Anita Mahadevan Jansen; Fiscal Year: 2009
    The incidence of skin cancer has been on the rise in recent years and as in most cancers, early diagnosis and thorough treatment (i.e., complete resection) are the keys to gain a favorable prognosis...
  67. Attenuating the retinal and CNS adverse effects of vigabatrin with NKCC1 inhibito
    Frances E Jensen; Fiscal Year: 2010
    ..Infantile spasms is a subgroup of epilepsy and has an incidence of approximately 1 per 2000 live births, with seizures being refractory and if untreated leads to greater than a ..
  68. Rapid Response Surveillance Study #09-5 - Constructing Geographic Areas in GIS fo
    Sally L Glaser; Fiscal Year: 2009
    ..The analysis of cancer incidence often suffers from the small population problem manifested in unreliable rate estimates, sensitivity to missing ..
  69. Chicago Community-Acquired Pneumonia Consortium
    Richard G Wunderink; Fiscal Year: 2010
    ..An accurate determination of the population-based incidence is critical to determine the opportunities for prevention, such as expansion of serotypes included in the ..
  70. Reasons for Racial Disparities in Venous Thromboembolism
    NEIL ADRIAN ZAKAI; Fiscal Year: 2010
    ..The greatest difficulty in studying the reasons for this disparity in incidence is due in great part to a paucity of African-Americans in research studies of VTE to date, especially where risk ..
  71. USING CLAIMS DATA FOR CANCER SURVEILLANCE
    Lynne Penberthy; Fiscal Year: 2000
    ..Because of its high incidence, devastating impact, and potential preventability, monitoring cancer epidemiology is essential...
  72. Mutational Cloning in Familial Dementia and Alzheimers Disease
    Wendy H Raskind; Fiscal Year: 2010
    ..Topic 08-AG-106 Cross-disease research to identify commonly targeted pathways or mechanisms between low incidence, neurogenetic disorders with high incidence, population-based disease...
  73. Venous thromboembolism among California cancer patients
    Helen Chew; Fiscal Year: 2003
    ..However, there is surprisingly little data regarding the incidence and time course of VTE and the risk of recurrent VTE among patients with a specific malignancy defined by ..
  74. SIRT1 Overexpression in Cellular Mitochondrial Metabolism and Function
    James Russell; Fiscal Year: 2009
    ..A major public health problem is the increase in the incidence of obesity-related diseases, such as diabetes and its complications and the increased incidence of ..
  75. FLORIDA FIREFIGHTER CANCER INCIDENCE AND MORTALITY
    Lora Fleming; Fiscal Year: 2001
    ..To date, there is only one published standardized incidence ratio study of firefighting and cancer...
  76. Determinants of Participation in an Anal Cancer Prevention Trial
    Joel Palefsky; Fiscal Year: 2010
    ..Among HIV-positive individuals, the incidence of anal cancer has continued to increase despite the availability of effective anti-retroviral therapy (ART)...
  77. MECHANISMS OF ALLOGENEIC STEM CELL EDUCATION IN SCID
    Rebecca H Buckley; Fiscal Year: 2010
    ..we plan to measure telomere length in the T cells of the various molecular types of transplants, 3) reducing the incidence of autoimmunity, and 4) contributing to their overall successful immune transplantation may be beneficial to ..
  78. EXPOSURE TO BLOOD AMONG NON-HOSPITAL HEALTH CARE WORKERS
    Jack Leiss; Fiscal Year: 2002
    ..Specific aims are to (i) estimate the incidence of blood exposure among non- hospital health care workers engaged in patient care, (ii) identify and quantity ..
  79. Nurses' Health Study: Short Sleep Duration and Risk of Hypertension
    JAMES GANGWISCH; Fiscal Year: 2009
    Short sleep duration has been shown to be associated with an increased risk for hypertension incidence, but previous prospective studies on this association did not examine the potential effect modifiers of menopausal status, hormone ..
  80. HAIR DYE USE AND RISK OF NONHODGKINS LYMPHOMA
    Tongzhang Zheng; Fiscal Year: 2000
    In the U.S., during past decades, the incidence of non-Hodgkin's lymphoma (NHL) has risen faster than that of all other cancer types except melanoma and lung cancer...
  81. Impact of Environmental Pollutants on Breast Cancer and*
    Julia Brody; Fiscal Year: 2005
    DESCRIPTION: Breast cancer incidence continues to rise in all age groups in the US, with an increase in age-adjusted incidence of more than 40% from the early 1970s to the late 1990s...