karnofsky performance status

Summary

Summary: A performance measure for rating the ability of a person to perform usual activities, evaluating a patient's progress after a therapeutic procedure, and determining a patient's suitability for therapy. It is used most commonly in the prognosis of cancer therapy, usually after chemotherapy and customarily administered before and after therapy. It was named for Dr. David A. Karnofsky, an American specialist in cancer chemotherapy.

Top Publications

  1. ncbi Initial chemotherapy in gliomatosis cerebri
    M Sanson
    Fédération de Neurologie Mazarin, Groupe hospitalier Pitié Salpêtrière and Université Pierre et Marie Curie, Paris, France
    Neurology 63:270-5. 2004
  2. ncbi Surgical patterns of care in operable lung carcinoma treated with radiation
    Joe Y Chang
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Thorac Oncol 1:526-31. 2006
  3. ncbi Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials
    L Gaspar
    Wayne State University, Detroit, MI 48201, USA
    Int J Radiat Oncol Biol Phys 37:745-51. 1997
  4. ncbi Diagnosis-specific prognostic factors, indexes, and treatment outcomes for patients with newly diagnosed brain metastases: a multi-institutional analysis of 4,259 patients
    Paul W Sperduto
    Gamma Knife Center, University of Minnesota, Minneapolis, MN 55387, USA
    Int J Radiat Oncol Biol Phys 77:655-61. 2010
  5. pmc Oncogenic reg IV is a novel prognostic marker for glioma patient survival
    Qi Wang
    Department of Experimental Surgery, Tangdu Hospital, Fourth Military Medical University, Xi an City 710032, China
    Diagn Pathol 7:69. 2012
  6. ncbi Neurocognitive function of patients with brain metastasis who received either whole brain radiotherapy plus stereotactic radiosurgery or radiosurgery alone
    Hidefumi Aoyama
    Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Int J Radiat Oncol Biol Phys 68:1388-95. 2007
  7. ncbi Conversion of Karnofsky Performance Status (KPS) and Eastern Cooperative Oncology Group Performance Status (ECOG) to Palliative Performance Scale (PPS), and the interchangeability of PPS and KPS in prognostic tools
    Ingrid De Kock
    Division of Palliative Care Medicine, Department of Oncology, University of Alberta, Edmonton Zone Palliative Care Program, Grey Nuns Community Hospital, Edmonton, Alberta, Canada School of Health Information Science, University of Victoria, Victoria, British Columbia, Canada
    J Palliat Care 29:163-9. 2013
  8. ncbi Radiosurgery alone for 5 or more brain metastases: expert opinion survey
    Jonathan P S Knisely
    Department of Therapeutic Radiology, Yale University School of Medicine and Yale Cancer Center, New Haven, Connecticut 06520 8040, USA
    J Neurosurg 113:84-9. 2010
  9. ncbi Association of surgically acquired motor and language deficits on overall survival after resection of glioblastoma multiforme
    Matthew J McGirt
    Department of Neurosurgery, The Neuro Oncology Surgical Outcomes Research Laboratory, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Neurosurgery 65:463-9; discussion 469-70. 2009
  10. ncbi Randomized phase II study of two gemcitabine schedules for patients with impaired performance status (Karnofsky performance status </= 70) and advanced non-small-cell lung cancer
    S Baka
    Christie Hospital, Wilmslow Rd, Withington, Manchester M20 4BX, United Kingdom
    J Clin Oncol 23:2136-44. 2005

Detail Information

Publications229 found, 100 shown here

  1. ncbi Initial chemotherapy in gliomatosis cerebri
    M Sanson
    Fédération de Neurologie Mazarin, Groupe hospitalier Pitié Salpêtrière and Université Pierre et Marie Curie, Paris, France
    Neurology 63:270-5. 2004
    ..Because of the diffuse nature of gliomatosis cerebri (GC), surgery is not suitable, and large field radiotherapy carries the risk of severe toxicity. In this setting, initial chemotherapy warrants further investigation...
  2. ncbi Surgical patterns of care in operable lung carcinoma treated with radiation
    Joe Y Chang
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Thorac Oncol 1:526-31. 2006
    ..To determine the national surgical practice patterns of care for operable lung cancer patients treated with radiation...
  3. ncbi Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials
    L Gaspar
    Wayne State University, Detroit, MI 48201, USA
    Int J Radiat Oncol Biol Phys 37:745-51. 1997
    ....
  4. ncbi Diagnosis-specific prognostic factors, indexes, and treatment outcomes for patients with newly diagnosed brain metastases: a multi-institutional analysis of 4,259 patients
    Paul W Sperduto
    Gamma Knife Center, University of Minnesota, Minneapolis, MN 55387, USA
    Int J Radiat Oncol Biol Phys 77:655-61. 2010
    ..The purpose of the present study was to identify significant diagnosis-specific prognostic factors and indexes (Diagnosis-Specific Graded Prognostic Assessment [DS-GPA])...
  5. pmc Oncogenic reg IV is a novel prognostic marker for glioma patient survival
    Qi Wang
    Department of Experimental Surgery, Tangdu Hospital, Fourth Military Medical University, Xi an City 710032, China
    Diagn Pathol 7:69. 2012
    ..However, the roles of Reg IV gene and its encoding product in human glioma have not been clearly understood. Therefore, the aim of this study was to investigate the clinicopathological significance of Reg IV expression in glioma...
  6. ncbi Neurocognitive function of patients with brain metastasis who received either whole brain radiotherapy plus stereotactic radiosurgery or radiosurgery alone
    Hidefumi Aoyama
    Department of Radiology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Int J Radiat Oncol Biol Phys 68:1388-95. 2007
    ..To determine how the omission of whole brain radiotherapy (WBRT) affects the neurocognitive function of patients with one to four brain metastases who have been treated with stereotactic radiosurgery (SRS)...
  7. ncbi Conversion of Karnofsky Performance Status (KPS) and Eastern Cooperative Oncology Group Performance Status (ECOG) to Palliative Performance Scale (PPS), and the interchangeability of PPS and KPS in prognostic tools
    Ingrid De Kock
    Division of Palliative Care Medicine, Department of Oncology, University of Alberta, Edmonton Zone Palliative Care Program, Grey Nuns Community Hospital, Edmonton, Alberta, Canada School of Health Information Science, University of Victoria, Victoria, British Columbia, Canada
    J Palliat Care 29:163-9. 2013
    The aim of our study was to assess whether the Karnofsky Performance Status (KPS), the Eastern Cooperative Oncology Group (ECOG) Performance Status, and the Palliative Performance Scale (PPS) are interchangeable individually or within two ..
  8. ncbi Radiosurgery alone for 5 or more brain metastases: expert opinion survey
    Jonathan P S Knisely
    Department of Therapeutic Radiology, Yale University School of Medicine and Yale Cancer Center, New Haven, Connecticut 06520 8040, USA
    J Neurosurg 113:84-9. 2010
    ..A survey was conducted at 2 radiosurgery meetings to determine which factors SRS practitioners emphasize in recommending SRS alone, and what physician characteristics are associated with recommending SRS alone for ≥ 5 metastases...
  9. ncbi Association of surgically acquired motor and language deficits on overall survival after resection of glioblastoma multiforme
    Matthew J McGirt
    Department of Neurosurgery, The Neuro Oncology Surgical Outcomes Research Laboratory, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Neurosurgery 65:463-9; discussion 469-70. 2009
    ..We set out to determine whether new-onset postoperative motor or speech deficits were associated with survival in our institutional experience with glioblastoma multiforme (GBM)...
  10. ncbi Randomized phase II study of two gemcitabine schedules for patients with impaired performance status (Karnofsky performance status </= 70) and advanced non-small-cell lung cancer
    S Baka
    Christie Hospital, Wilmslow Rd, Withington, Manchester M20 4BX, United Kingdom
    J Clin Oncol 23:2136-44. 2005
    ..two treatment schedules of gemcitabine in patients with non-small-cell lung cancer (NSCLC) and impaired Karnofsky performance status (KP). Primary objectives were to record changes from baseline KP and to assess symptom palliation...
  11. ncbi The use of hypofractionated intensity-modulated irradiation in the treatment of glioblastoma multiforme: preliminary results of a prospective trial
    Khalil Sultanem
    Department of Oncology, Division of Radiation Oncology, McGill University, Montreal, Quebec, Canada
    Int J Radiat Oncol Biol Phys 58:247-52. 2004
    ..We report our preliminary results using hypofractionated intensity-modulated accelerated radiotherapy regimen in the treatment of patients with GBM...
  12. ncbi Properly selected patients with multiple brain metastases may benefit from aggressive treatment of their intracranial disease
    Bruce E Pollock
    Department of Neurological Surgery, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    J Neurooncol 61:73-80. 2003
    ..The median patient age was 58 years, the median Karnofsky performance status (KPS) was 90, and the median number of tumors was three...
  13. ncbi Validation of the RTOG recursive partitioning analysis (RPA) classification for brain metastases
    L E Gaspar
    University of Colorado Health Science Center, Denver, CO, USA
    Int J Radiat Oncol Biol Phys 47:1001-6. 2000
    ..These classes were based on Karnofsky performance status (KPS), primary tumor status, presence of extracranial system metastases, and age...
  14. ncbi Convection-enhanced delivery of topotecan into diffuse intrinsic brainstem tumors in children
    Richard C E Anderson
    Departments of Neurosurgery, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    J Neurosurg Pediatr 11:289-95. 2013
    ..403 mg in 6.04 ml over 100 hours. Her Karnofsky Performance Status (KPS) score was 60 before CED and 50 posttreatment...
  15. ncbi Neoplastic meningitis-related prognostic significance of the Karnofsky performance status
    Marc C Chamberlain
    University of Washington, Department of Neurology and Neurological Surgery, Fred Hutchinson Cancer Research Center, Seattle Cancer Care Alliance, 825 Eastlake Ave E, Mail Stop G 4940, Seattle, WA 98109 1023, USA
    Arch Neurol 66:74-8. 2009
    The prognostic significance of Karnofsky performance status in neoplastic meningitis (NM) has not been demonstrated in patient groups similarly matched for known prognostic variables.
  16. ncbi Should patient-rated performance status affect treatment decisions in advanced lung cancer?
    Esther Dajczman
    Department of Medicine, Division of Pulmonary Diseases, Sir Mortimer B Davis Jewish General Hospital, Montreal, Quebec, Canada
    J Thorac Oncol 3:1133-6. 2008
    ..We compared the Pt-PS with MD-PS in patients with advanced non-small cell lung cancer and compared the effect of each rating on eligibility for a hypothetical clinical trial...
  17. ncbi Chemotherapy improves low performance status lung cancer patients
    J P Sculier
    Dept of Critical Care and Thoracic Oncology, Institut Jules Bordet, 1 rue Héger Bordet, B 1000 Bruxelles, Belgium
    Eur Respir J 30:1186-92. 2007
    ..2 versus 2.1%). In conclusion, combination chemotherapy is associated with clinical improvement in a substantial number of patients with advanced nonsmall cell lung cancer of poor performance status...
  18. pmc Prognostic factors for survival of patients with glioblastoma: recursive partitioning analysis
    Kathleen R Lamborn
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143 0112, USA
    Neuro Oncol 6:227-35. 2004
    ..An intermediate-risk group included patients with Karnofsky performance status (KPS) >70, subtotal or total resection, and age between 40 and 65...
  19. ncbi Testing psychometric properties of the standard Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire 30 (EORTC QLQ-C30)
    Hong Zhao
    SSchool of Nursing, Peking Union Medical College, Badachulu, Shijingshan District, Bejling 100041, China
    J Epidemiol 14:193-203. 2004
    ..The objective of this study was to evaluate the psychometric properties of the standard Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire 30 (EORTC QLQ-C30, version 3.0)...
  20. ncbi Neurocognitive outcome in brain metastases patients treated with accelerated-fractionation vs. accelerated-hyperfractionated radiotherapy: an analysis from Radiation Therapy Oncology Group Study 91-04
    W F Regine
    University of Kentucky, Department of Radiation, Lexington, KY, USA
    Int J Radiat Oncol Biol Phys 51:711-7. 2001
    ..accelerated hyperfractionated (AH) whole-brain radiation therapy (WBRT)...
  21. ncbi Assessing cancer symptoms in adolescents with cancer using the Taiwanese version of the M. D. Anderson Symptom Inventory
    Tsui Hwa Tseng
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan
    Cancer Nurs 31:E9-16. 2008
    ..adolescent cancer patients with a low functional status and those with a high functional status (Karnofsky Performance Status scores <or= 80 and >80, respectively)...
  22. ncbi Comorbidity and Karnofksy performance score are independent prognostic factors in stage III non-small-cell lung cancer: an institutional analysis of patients treated on four RTOG studies. Radiation Therapy Oncology Group
    Selim Firat
    Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Int J Radiat Oncol Biol Phys 54:357-64. 2002
    ..To determine the prognostic role of comorbidity in Stage III non-small cell lung cancer (NSCLC) treated definitively with radiotherapy alone...
  23. ncbi Stereotactic radiosurgical treatment in 103 patients for 153 cerebral melanoma metastases
    Ugur Selek
    Department of Radiation Oncology, Brain Tumor Center, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 59:1097-106. 2004
    ..To report on the outcome of patients with melanoma brain metastases treated with stereotactic radiosurgery (SRS)...
  24. ncbi Symptom monitoring and dependent care during cancer treatment in children: pilot study
    Phoebe D Williams
    University of Kansas School of Nursing, Kansas City, KS 66160, USA
    Cancer Nurs 29:188-97. 2006
    ..The first 2 categories were the most used. Systematic assessment with a self-report checklist enables the provider to identify and prioritize (according to reported severity) those symptoms needing intervention...
  25. ncbi Quality of life following allogeneic stem cell transplantation, comparing parents' and children's perspective
    Ulla Forinder
    Department of Paediatrics, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden
    Pediatr Transplant 10:491-6. 2006
    ....
  26. ncbi Comorbidity and KPS are independent prognostic factors in stage I non-small-cell lung cancer
    Selim Firat
    Department of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Int J Radiat Oncol Biol Phys 52:1047-57. 2002
    ..To determine the prognostic role of comorbidity in Stage I non-small-cell lung cancer (NSCLC) treated with surgery or radiotherapy (RT)...
  27. pmc Prognostic value of performance status assessed by patients themselves, nurses, and oncologists in advanced non-small cell lung cancer
    M Ando
    Department of Preventive Medicine Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Br J Cancer 85:1634-9. 2001
    ..These results showed that the assessment by the patients themselves is different from those by the nurses and the oncologists and provided additional support for the use of the assessment by oncologists in clinical oncology...
  28. pmc A prognostic index that predicts outcome following palliative whole brain radiotherapy for patients with metastatic malignant melanoma
    S L Morris
    Melanoma Unit, The Royal Marsden Hospital NHS Trust, 203 Fulham Road, London SW3 6JJ, UK
    Br J Cancer 91:829-33. 2004
    ..We identified that patients with RPA class 3, leptomeningeal involvement or RPA class 2 with poor prognostic index are unlikely to benefit from palliative WBRT...
  29. ncbi Symptom clusters in cancer patients with brain metastases
    E Chow
    Rapid Response Radiotherapy Program, Odette Cancer Centre, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada
    Clin Oncol (R Coll Radiol) 20:76-82. 2008
    ..To explore the presence of symptom clusters in patients with brain metastases...
  30. ncbi Symptom clusters in patients with cancer with metastatic bone pain
    Stephanie Hadi
    Department of Radiation Oncology, Odette Cancer Centre, Toronto, Ontario, Canada
    J Palliat Med 11:591-600. 2008
    ..Secondary objectives were to determine whether symptom clusters change with palliative radiotherapy (RT) and to compare the difference between responders and nonresponders to radiation...
  31. ncbi Neurobehavioral status and health-related quality of life in newly diagnosed high-grade glioma patients
    M Klein
    Department of Medical Psychology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Clin Oncol 19:4037-47. 2001
    ..To evaluate the health-related quality of life (HRQOL) and cognitive functioning of high-grade glioma patients in the postneurosurgical period...
  32. ncbi Results of whole brain radiotherapy and recursive partitioning analysis in patients with brain metastases from renal cell carcinoma: a retrospective study
    Steven B Cannady
    Department of Otolaryngology, Brain Tumor Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Int J Radiat Oncol Biol Phys 58:253-8. 2004
    ..To determine the benefit of whole brain radiotherapy (WBRT) and the use of the Radiation Therapy Oncology Group (RTOG) recursive partitioning analysis (RPA) classification system in patients with brain metastases from renal cell carcinoma...
  33. ncbi Safety and efficacy of permanent iodine-125 seed implants and carmustine wafers in patients with recurrent glioblastoma multiforme
    Borimir J Darakchiev
    Department of Neurosurgery, The Neuroscience Institute, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0515, USA
    J Neurosurg 108:236-42. 2008
    ..This study assessed the efficacy and safety of these therapies in combination following tumor resection...
  34. pmc Performance status score: do patients and their oncologists agree?
    S P Blagden
    Department of Oncology, Box 193, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2QQ, UK
    Br J Cancer 89:1022-7. 2003
    ..Although oncologists should continue to score PS objectively, it may benefit their clinical practice to involve their patients in these assessments...
  35. ncbi Prediction of survival for advanced cancer patients by recursive partitioning analysis: role of Karnofsky performance status, quality of life, and symptom distress
    Shirley S Hwang
    Section of Hematology Oncology, VA New Jersey Health Care System, East Orange, New Jersey 07018, USA
    Cancer Invest 22:678-87. 2004
    ..The Cox model analysis also was performed. Both RPA and Cox models included Karnofsky performance status (KPS), age, FACT-G subscales, and MSAS-SF subscales as survival predictors...
  36. ncbi Allelic loss of chromosome 1p and radiotherapy plus chemotherapy in patients with oligodendrogliomas
    G S Bauman
    Department of Oncology, University of Western Ontario and London Regional Cancer Centre, London, Ontario, Canada
    Int J Radiat Oncol Biol Phys 48:825-30. 2000
    ....
  37. ncbi Prognostic factors in advanced gastrointestinal cancer patients with weight loss
    P O'Gorman
    University Department of Surgery, Royal Infirmary, Glasgow, UK
    Nutr Cancer 37:36-40. 2000
    ..6%), we prospectively examined the importance of metastatic spread, anthropometry, blood parameters, Karnofsky performance status, appetite, and the acute-phase response as predictors of survival...
  38. pmc Leptomeningeal metastases in the MRI era
    J L Clarke
    Department of Neurology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Neurology 74:1449-54. 2010
    ..The diagnostic gold standard has been CSF cytology, but MRI is now used routinely for diagnosis. Diagnosis and prognosis of LM has not been studied in the MRI era...
  39. ncbi A new scoring system to predicting the survival of patients treated with whole-brain radiotherapy for brain metastases
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Strahlenther Onkol 184:251-5. 2008
    ..To create a scoring system to estimate survival of patients who received whole-brain radiotherapy (WBRT) for brain metastases...
  40. ncbi Management of patients with non-small cell lung cancer and poor performance status
    Ramaswamy Govindan
    Department of Medicine, Washington University School of Medicine, Suite 108, 4960 Children s Place, St Louis, MO 63110, USA
    Curr Treat Options Oncol 4:55-9. 2003
    ..The suggested treatment options for patients with metastatic disease and poor PS are single-agent chemotherapy or supportive care...
  41. ncbi A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival
    M Lacroix
    Department of Neurosurgery, The University of Texas M. D. Anderson Cancer Center, Houston 77030, USA
    J Neurosurg 95:190-8. 2001
    ..Gross-total tumor resection is associated with longer survival in patients with GBM, especially when other predictive variables are favorable...
  42. ncbi Resection of brain metastases previously treated with stereotactic radiosurgery
    Giacomo G Vecil
    Department of Neurosurgery, Brain and Spine Tumor Center, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    J Neurosurg 102:209-15. 2005
    ..Consequently, the authors reviewed their institutional experience with this clinical scenario to assess the efficacy of surgical intervention...
  43. ncbi Comparison of short-course versus long-course whole-brain radiotherapy in the treatment of brain metastases
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Strahlenther Onkol 184:30-5. 2008
    ..This study compares 20 Gy in five fractions (treatment time: 1 week) to longer programs, with higher doses including 30 Gy in ten fractions (2 weeks) and 40 Gy in 20 fractions (4 weeks)...
  44. pmc Surgical and palliative management and outcome in 184 patients with hilar cholangiocarcinoma: palliative photodynamic therapy plus stenting is comparable to r1/r2 resection
    Helmut Witzigmann
    Department of Surgery II, University of Leipzig, Leipzig, Germany
    Ann Surg 244:230-9. 2006
    ..Second, to compare long-term outcome in patients undergoing surgical or palliative treatment, and third to evaluate the role of photodynamic therapy in this concept...
  45. ncbi Investigating the palliative efficacy of whole-brain radiotherapy for patients with multiple-brain metastases and poor prognostic features
    G E Gerrard
    Cookridge Hospital, Cancer Research, Leeds, UK
    Clin Oncol (R Coll Radiol) 15:422-8. 2003
    ..Quality of life (QoL) and other parameters to assess the palliative efficacy of WBRT have not previously been studied in this group of patients. We therefore attempted to do this...
  46. ncbi [Guidelines for the diagnosis and management of brain metastases]
    Elona Juozaityte
    Clinic of Oncology, Kaunas University of Medicine, 3007 Kaunas, Lithuania
    Medicina (Kaunas) 39:804-11. 2003
    ..Chemotherapy is not the primary therapy for these patients. The overall prognosis for patients with brain metastases remains poor...
  47. ncbi Health status measurements at diagnosis as predictors of survival among adults with brain tumors
    Helen McCarter
    The Juravinski Cancer Centre, Hamilton, Ontario, Canada
    J Clin Oncol 24:3636-43. 2006
    ..The intent of this study was to determine whether baseline measures of functional capacity and performance could be used to predict survival in adults following the diagnosis of brain tumors...
  48. ncbi Hypofractionated radiotherapy for poor prognosis malignant glioma: matched pair survival analysis with MRC controls
    J J McAleese
    Neuro oncology Unit and Academic Unit of Radiotherapy and Oncology, The Institute of Cancer Research and The Royal Marsden NHS Trust, London, UK
    Radiother Oncol 67:177-82. 2003
    ..To assess the survival benefit of palliative hypofractionated radiotherapy in patients with poor prognosis high grade glioma by a matched comparison to conventionally treated controls...
  49. ncbi Intensified local treatment and systemic therapy significantly increase survival in patients with brain metastases from advanced breast cancer - a retrospective analysis
    Rupert Bartsch
    Department of Radiotherapy and Radiobiology, Medical University of Vienna, Vienna, Austria
    Radiother Oncol 80:313-7. 2006
    ..Brain metastases have evolved from a rare to a frequently encountered event in advanced breast cancer due to advances in palliative systemic treatment...
  50. ncbi Validation of the RTOG recursive partitioning analysis (RPA) classification for small-cell lung cancer-only brain metastases
    Gregory M M Videtic
    Department of Radiation Oncology, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Int J Radiat Oncol Biol Phys 67:240-3. 2007
    ..Clinical trials for patients with brain metastases generally exclude small-cell lung cancer (SCLC) cases. We hypothesize that the RPA classes are valid in the setting of SCLC brain metastases...
  51. ncbi Sequential vinorelbine and docetaxel in advanced non-small cell lung cancer patients age 70 and older and/or with a performance status of 2: a phase II trial of the Southwest Oncology Group (S0027)
    Paul J Hesketh
    Caritas St Elizabeth s Medical Center of Boston, Boston, MA, USA
    J Thorac Oncol 1:537-44. 2006
    ....
  52. ncbi Recursive partitioning analysis (RPA) class does not predict survival in patients with four or more brain metastases
    Carsten Nieder
    Department of Radiotherapy and Radiologic Oncology, Klinikum rechts der Isar, Technical University of Munich, Germany
    Strahlenther Onkol 179:16-20. 2003
    ..If up to three brain metastases are present, surgical resection or radiosurgery are currently being considered in case of favorable prognostic factors...
  53. ncbi Salvage therapy in patients with glioblastoma: is there any benefit?
    Peter Hau
    Klinik und Poliklinik für Neurologie der Universität Regensburg im Bezirksklinikum, Regensburg, Germany
    Cancer 98:2678-86. 2003
    ..Their objectives were to improve patients' overall survival with sustained quality of life and to make comparisons with overall survival in unselected patients...
  54. ncbi Treatment of solitary brain metastasis. Resection followed by whole brain radiation therapy (WBRT) and a radiation boost to the metastatic site
    Dirk Rades
    Department of Radiotherapy and Radiooncology, University Hospital Hamburg Eppendorf, Germany
    Strahlenther Onkol 180:144-7. 2004
    ..The optimum radiation schedule has yet to be defined. The authors' experience with a postoperative approach including WBRT and a radiation boost to the metastatic site is presented...
  55. ncbi Prognostication in hospice care: can the palliative performance scale help?
    Barbara Head
    Program for Advanced Chronic Illness and End of Life Care, University of Louisville, Louisville, Kentucky 40202, USA
    J Palliat Med 8:492-502. 2005
    ..Prognostic information facilitates more realistic decision making regarding ongoing treatment, fosters risk-benefit considerations of specific interventions, and contributes to appropriate utilization of health care services...
  56. ncbi Lymphopenia: a new independent prognostic factor for survival in patients treated with whole brain radiotherapy for brain metastases from breast carcinoma
    Line Claude
    Department of Radiation Oncology, Hopital Edouard Herriot, Lyon, France
    Radiother Oncol 76:334-9. 2005
    ..To determine overall survival (OS) and independent prognostic factors in patients with brain metastases (BM) from breast cancer treated by whole brain radiotherapy (WBR)...
  57. ncbi Role of stereotactic radiosurgery as a primary treatment option in the management of newly diagnosed multiple (3-6) intracranial metastases
    Ajay Jawahar
    Department of Neurosurgery, Louisiana State University Health Sciences Center in Shreveport, Shreveport, LA 71130, USA
    Surg Neurol 64:207-12. 2005
    ..The objective of this study was to assess the role of stereotactic radiosurgery in the management of newly diagnosed multiple intracranial metastases from known primary cancer locations...
  58. ncbi Results of the whole-brain radiotherapy for patients with brain metastases from lung cancer: the RTOG RPA intra-classes analysis
    Lucyna Kepka
    Department of Radiation Oncology, Memorial M Sklodowska Curie Cancer Center and Institute, Warsaw, Poland
    Acta Oncol 44:389-98. 2005
    ..RTOG RPA classes maintain their prognostic significance for patients with BM from lung cancer not participating in clinical trials...
  59. ncbi Gamma knife surgery for the treatment of intracranial metastases from breast cancer
    Sharad Goyal
    Department of Radiation Oncology, Howard University Hospital, Washington, DC, USA
    J Neurosurg 103:218-23. 2005
    ..The goal of this study was to evaluate the effectiveness and limitations of gamma knife surgery (GKS) in the treatment of intracranial breast carcinoma lesions...
  60. ncbi Recursive partitioning analysis of prognostic factors for patients with four or more intracranial metastases treated with radiosurgery
    A K Bhatnagar
    Deptartments of Radiation Oncology, Neurological Surgery, Center for Image Guided Neurosurgery, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
    Technol Cancer Res Treat 6:153-60. 2007
    ....
  61. ncbi The role of surgery in the treatment of brain metastasis: a retrospective review
    S Yoshida
    Department of Neurosurgery, Niigata Cancer Center Hospital, Niigata, Japan
    Acta Neurochir (Wien) 146:767-70. 2004
    ..To study the role of surgery for brain metastasis, we reviewed the records of 646 patients with brain metastasis...
  62. ncbi Gliomatosis cerebri: a review of 296 cases from the ANOCEF database and the literature
    Sophie Taillibert
    Federation de Neurologie, Groupe Hospitalier Pitie Salpetriere, 47 83 Bd de l Hopital, 75651, Paris, Cedex 13, France
    J Neurooncol 76:201-5. 2006
    ..Up-front chemotherapy benefit to some patients and may be preferred to whole brain radiotherapy. However, the many bias of such retrospective heterogeneous data claim for multicentric clinical trials in this rare disease...
  63. ncbi Indicators of functional status for primary malignant brain tumour patients
    Miguel Bussière
    Department of Clinical Neurological Sciences, London Health Sciences of Western Ontario, Canada
    Can J Neurol Sci 32:50-6. 2005
    ..We compared the functional status and survival time of patients with malignant gliomas...
  64. ncbi Prognostic factors affecting the outcome of brain metastases from breast cancer
    Mu Tai Liu
    Department of Radiation Oncology, Changhua Christian Hospital, Changhua, Taiwan, Republic of China
    Support Care Cancer 14:936-42. 2006
    ..The purpose of this study is to analyze the overall survival rate of patients with brain metastases from breast cancer and to determine prognostic factors affecting outcomes of these patients...
  65. ncbi The use of recursive partitioning analysis grouping in patients with brain metastases from non-small-cell lung cancer
    Hülya Gülbaş
    MD, Department of Radiation Oncology, Inonu University Faculty of Medicine, Malatya, TR 44280, Turkey
    Jpn J Clin Oncol 36:193-6. 2006
    ..This study evaluates the use of recursive partitioning analysis (RPA) grouping in an attempt to predict the survival probabilities in patients with brain metastases from non-small-cell lung cancer (NSCLC)...
  66. ncbi Hematologic counts and clinical correlates in 1201 newly diagnosed lung cancer patients
    D Ferrigno
    Azienda Ospedaliera S Croce e Carle, Cuneo and Cuneo Lung Cancer Study Group, Cuneo, I 12100, Italy
    Monaldi Arch Chest Dis 59:193-8. 2003
    ..Many factors have prognostic significance in lung cancer. However, their practical value remains controversial except for stage of disease, performance status, and, perhaps, weight loss...
  67. ncbi Pathologic N1 non-small cell lung cancer: correlation between pattern of lymphatic spread and prognosis
    Alessandro Marra
    Department of Thoracic Surgery and Endoscopy, Ruhrlandklinik, Essen, Germany
    J Thorac Cardiovasc Surg 125:543-53. 2003
    ..Patients with N1 non-small cell lung cancer represent a heterogeneous population with varying long-term survivals. Prognosis and pattern of recurrence seem to be particularly affected by the level of lymph node involvement...
  68. ncbi Multicentric French study on adult intracranial ependymomas: prognostic factors analysis and therapeutic considerations from a cohort of 152 patients
    Philippe Metellus
    Department of Neurosurgery, Timone Hospital, Marseille, France
    Brain 130:1338-49. 2007
    ..The role of adjuvant radiotherapy for patients with incompletely resected low-grade ependymomas seems to be beneficial but remains to be addressed for high-grade tumours...
  69. ncbi Pronostic factors of synchronous brain metastases from lung cancer
    N Penel
    Oscar Lambret Cancer Center, rue Frederic Combemale, B.P. 307, 59020 Lille, France
    Lung Cancer 33:143-54. 2001
    ..However, further studies are necessary to evaluate quality of life with or without carcinologic treatment...
  70. ncbi Prognostic relevance of p53 protein expression in glioblastoma
    Peter Birner
    Institute of Clinical Pathology, University of Vienna, Vienna, Austria
    Oncol Rep 9:703-7. 2002
    ..0399, log-rank test). In multivariate analysis of overall survival (Cox regression) only postoperative Karnofsky performance status remained as independent prognostic factor...
  71. ncbi [Stereotactic radiation therapy with a modified linear accelerator in patients with brain metastases]
    A L Grosu
    , Klinikum rechts der Isar, , Ismaninger Str. 22,
    Nervenarzt 72:770-81. 2001
    ..In comparison to surgery, stereotactic radiotherapy has the advantages of shorter treatment time and lower treatment-related morbidity and mortality...
  72. ncbi The palliative prognostic score and survival in patients with advanced solid tumors receiving chemotherapy
    Davide Tassinari
    Department of Oncology, City Hospital, Rimini, Italy
    Support Care Cancer 16:359-70. 2008
    ..To evaluate the accuracy of the Palliative Prognostic Score (PaP score) in selecting metastatic gastrointestinal or nonsmall-cell lung cancer patients candidate to palliative chemotherapy...
  73. ncbi Factors predicting survival in patients with advanced oesophageal cancer: a prospective multicentre evaluation
    H Bergquist
    Department of Otorhinolaryngology, Sahlgrenska University Hospital, Goteborg, Sweden
    Aliment Pharmacol Ther 27:385-95. 2008
    ..Oesophageal cancer is often diagnosed at an advanced stage, with poor prognosis and severe morbidity. In majority of cases, palliative treatment is the only option available...
  74. ncbi Outcome of whole-brain irradiation for breast cancer patients
    Roar Johansen
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Acta Oncol 47:261-6. 2008
    ..To determine the overall survival (OS) of breast cancer patients treated by Whole Brain Radiation Therapy (WBRT) and possible important prognostic factors for OS...
  75. ncbi Risk of isolated nodal failure for non-small cell lung cancer (NSCLC) treated with the elective nodal irradiation (ENI) using 3D-conformal radiotherapy (3D-CRT) techniques--a retrospective analysis
    Lucyna Kepka
    Department of Radiation Oncology, M Sklodowska Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland
    Acta Oncol 47:95-103. 2008
    ..To estimate retrospectively the rate of isolated nodal failures (INF) in NSCLC patients treated with the elective nodal irradiation (ENI) using 3D-conformal radiotherapy (3D-CRT)...
  76. ncbi Multiple myeloma: surgery of the spine: retrospective analysis of 27 patients
    Hans Roland Dürr
    Department of Orthopaedics and Orthopaedic Surgery, University of Rostock, Rostock, Germany
    Spine (Phila Pa 1976) 27:320-4; discussion 325-6. 2002
    ..The authors report on the clinical course of 27 consecutive patients surgically treated for solitary or multiple myeloma of the spine...
  77. ncbi Radiosurgery for brain metastases from primary lung carcinoma
    R Hoffman
    Department of Radiation Oncology, University of California, San Francisco 94143-0226, USA
    Cancer J 7:121-31. 2001
    ..Prospective, randomized trials are needed to further investigate the role of radiosurgery with and without whole-brain radiotherapy for brain metastases...
  78. ncbi Brain metastases from breast carcinoma: validation of the radiation therapy oncology group recursive partitioning analysis classification and proposition of a new prognostic score
    Romuald Le Scodan
    Department of Radiation Oncology, Centre Rene Huguenin, Saint Cloud, France
    Int J Radiat Oncol Biol Phys 69:839-45. 2007
    ....
  79. ncbi Prognostic factor analysis in advanced gastric cancer patients treated with hydroxyurea, leucovorin, 5-fluorouracil, and cisplatin (HLFP regimen)
    Christophe Louvet
    Service de médecine interne oncologie, Hopital St Antoine, 184 rue du fbg St Antonie, 75012, Paris, France
    Cancer Invest 21:14-20. 2003
    ..Response rate and survival in patients with gastric linitis or diffuse forms were in the same range as in patients with intestinal forms of gastric adenocarcinoma...
  80. ncbi Quality of life: Gamma Knife surgery and whole brain radiation therapy
    Janice Nesbitt
    Gamma Knife Program, Health Sciences Centre, Winnipeg, Manitoba
    Axone 28:36-41. 2007
    ..Both WBRT and GKS are reviewed and discussed in terms of quality of life and health outcomes. The case studies of two individuals who underwent Gamma Knife surgery are presented...
  81. ncbi Stereotactic radiosurgery for brain metastases from colorectal cancer
    A Schoeggl
    Department of Neurosurgery, University of Vienna, Austria
    Int J Colorectal Dis 17:150-5. 2002
    ..We evaluated results following stereotactic radiosurgery (SR) for patients with metastatic colorectal cancer to identify efficacy of SR and prognostic factors for survival...
  82. ncbi Quality of life in patients with brain metastases treated with a palliative course of whole-brain radiotherapy
    Megan Doyle
    Department of Radiation Oncology, Toronto Sunnybrook Regional Cancer Centre, Toronto, Ontario, Canada
    J Palliat Med 10:367-74. 2007
    ..The secondary objective was to assess the level of agreement between patient and proxy quality of life scores...
  83. ncbi Changes in patterns of care for limited-stage small-cell lung cancer: results of the 99-01 patterns of care study-a nationwide survey in Japan
    Takashi Uno
    Department of Radiology, Chiba University Graduate School of Medicine, Chiba, Japan
    Int J Radiat Oncol Biol Phys 71:414-9. 2008
    ..This study was undertaken to analyze the practice process of thoracic radiotherapy (TRT) and evaluate changes in patterns of care for patients with limited-stage small-cell lung cancer (LS-SCLC) in Japan...
  84. ncbi Validity, reliability and clinical relevance of EORTC QLQ-C30 and LC13 in patients with chest malignancies in a palliative setting
    Mercedes Nicklasson
    Department of Respiratory Medicine and Allergology, Goteborg University, Gothenburg 413 45, Sweden
    Qual Life Res 16:1019-28. 2007
    ..To evaluate the reliability and validity of the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 and LC13 questionnaire in a palliative setting, and to undertake a broad clinical evaluation of the questionnaire...
  85. ncbi Patients with brain metastases: hope for recursive partitioning analysis (RPA) class 3
    Johannes Lutterbach
    Radiologische Universitatsklinik, Abteilung Strahlenheilkunde, Hugstetter Strasse 55, 79106 Freiburg, Germany
    Radiother Oncol 63:339-45. 2002
    ....
  86. ncbi [Palliative treatment of brain metastases with gamma knife]
    J Siegfried

    Ther Umsch 58:413-8. 2001
    ....
  87. ncbi A boost in addition to whole-brain radiotherapy improves patient outcome after resection of 1 or 2 brain metastases in recursive partitioning analysis class 1 and 2 patients
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Germany
    Cancer 110:1551-9. 2007
    ..The current study was conducted to compare 2 treatment regimens including surgical resection and whole-brain radiotherapy (WBRT) for patients with 1 to 2 brain metastases...
  88. ncbi Intra-arterial infusion of 5-fluorouracil plus granulocyte-macrophage colony-stimulating factor (GM-CSF) and chemoembolization with melphalan in the treatment of disseminated colorectal liver metastases
    H Muller
    Department of Surgical Oncology, Carl von Hess Hospital, D 97762 Hammelburg, Germany
    Eur J Surg Oncol 27:652-61. 2001
    ..We compared two prospective trials of intra-arterial cytokine/chemotherapeutic infusion plus chemoembolization in the treatment of inoperable colorectal liver metastases...
  89. ncbi Cytokine gene polymorphisms in hemodialysis patients: association with comorbidity, functionality, and serum albumin
    Vaidyanathapuram S Balakrishnan
    Division of Nephrology, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Kidney Int 65:1449-60. 2004
    ....
  90. ncbi Phase I study and pharmacokinetics of menogaril (NSC 269148) in patients with hepatic dysfunction
    M J Egorin
    Division of Developmental Therapeutics, University of Maryland School of Medicine, Baltimore
    Cancer Res 47:6104-10. 1987
    ..Patient characteristics were median age, 63 years (range, 28-80 years), 14 male/4 female, and median Karnofsky performance status 80% (range, 60-100%)...
  91. ncbi Procarbazine, lomustine, and vincristine (PCV) chemotherapy for anaplastic astrocytoma: A retrospective review of radiation therapy oncology group protocols comparing survival with carmustine or PCV adjuvant chemotherapy
    M D Prados
    Department of Neurosurgery, University of California San Francisco, San Francisco, CA 94143 0372, USA
    J Clin Oncol 17:3389-95. 1999
    ..To determine any differences in outcome for patients with anaplastic astrocytoma (AA) treated with adjuvant carmustine (BCNU) versus procarbazine, lomustine, and vincristine (PCV) chemotherapy...
  92. ncbi Fast-track rehabilitation for lung cancer lobectomy: a five-year experience
    João Carlos Das-Neves-Pereira
    Thoracic Surgery Department of Hôpital Européen Georges Pompidou, Paris, France
    Eur J Cardiothorac Surg 36:383-91; discussion 391-2. 2009
    ..Our objective is to describe a five-year experience with fast-track rehabilitation for lung cancer lobectomy...
  93. ncbi Is the therapeutic index better with gemcitabine-based chemoradiation than with 5-fluorouracil-based chemoradiation in locally advanced pancreatic cancer?
    Christopher H Crane
    Pancreatic Tumor Study Group, Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 52:1293-302. 2002
    ..To retrospectively compare the toxicity and efficacy of concurrent gemcitabine-based chemoradiation with that of concurrent 5-fluorouracil (5-FU)-based chemoradiation in patients with unresectable pancreatic cancer...
  94. ncbi Acute effects of combined photodynamic therapy and hyperbaric oxygenation in lung cancer--a clinical pilot study
    F Tomaselli
    Department of Surgery, Division of Thoracic and Hyperbaric Surgery, University Medical School, Graz, Austria
    Lasers Surg Med 28:399-403. 2001
    ..The use of hyperbaric oxygenation (HBO) increases the amount of oxygen available for the process may thereby enhance the efficacy of PDT. We investigated the acute effects on tumor stenosis after combined PDT/HBO...
  95. ncbi The effects of Chinese calligraphy handwriting and relaxation training in Chinese Nasopharyngeal Carcinoma patients: a randomized controlled trial
    Xue Ling Yang
    Department of Psychology, Sun Yat Sen University, Xin Gang Xi Road 135, Guangzhou 510275, Guangdong, China
    Int J Nurs Stud 47:550-9. 2010
    ..Chinese calligraphy handwriting is the practice of traditional Chinese brush writing, researches found calligraphy had therapeutic effects on certain diseases, some authors argued that calligraphy might have relaxation effect...
  96. ncbi A phase III comparison of radiation therapy with or without recombinant beta-interferon for poor-risk patients with locally advanced non-small-cell lung cancer (RTOG 93-04)
    Jeffrey D Bradley
    Radiation Oncology Center, Washington University Medical Center, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 52:1173-9. 2002
    ..Based on these data, the Radiation Therapy Oncology Group (RTOG) initiated a Phase III trial to test the efficacy of beta-interferon in poor-risk patients with Stages IIIA and IIIB non-small-cell lung carcinoma...
  97. ncbi Prevalence of 25(OH) vitamin D insufficiency and deficiency in chronic kidney disease stage 5 patients on hemodialysis
    Elisa Del Valle
    Fresenius Medical Care, Quilmes, Argentina
    Hemodial Int 11:315-21. 2007
    ..1%) at the end of winter, in stage 5 CKD patients on HD, and lower values seem to be related to decreased sunlight exposure, female gender, increased BMI, and worse functional class...
  98. ncbi Two different schedules of irinotecan (CPT-11) in patients with advanced colorectal carcinoma relapsing after a 5-fluorouracil and leucovorin combination. A randomized study
    N Tsavaris
    Oncology Unit, Department of Pathophysiology, Laikon General Hospital, University of Athens School of Medicine, 11527 Athens, Greece
    Cancer Chemother Pharmacol 52:514-9. 2003
    ..To evaluate the efficacy and safety of irinotecan as second-line treatment in patients with advanced colorectal cancer (ACC) failing or relapsing after 5-fluorouracil (5-FU) plus leucovorin (LV) standard chemotherapy...
  99. ncbi [Comparative study of video-assisted thoracoscopic surgery vs thoracic tube drainage in synthetic therapy for malignant pleural effusion secondary to non-small cell lung cancer]
    Li jia Gu
    Department of Cardiothoracic Surgery, Nanfang Hosital, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:1023-6. 2006
    ..To study the value of video-assisted thoracoscopic surgery (VATS) and identify its indications in synthetic therapy for malignant pleural effusion secondary to non-small cell lung cancer...
  100. ncbi [Comparison of rhenium-188, rhenium-186-HEDP and strontium-89 in palliation of painful bone metastases]
    K Liepe
    Klinik und Poliklinik fur Nuklearmedizin, Universitätsklinikum Carl Gustav Carus der technischen Universität Dresden, Deutschland
    Nuklearmedizin 39:146-51. 2000
    ..Furthermore, first results were reported on the suitability for such kind of therapy of the generator produced radionuclide rhenium-188...
  101. ncbi Modifying radical radiotherapy in high grade gliomas; shortening the treatment time through acceleration
    M Brada
    Neuro Oncology Unit, The Royal Marsden NHS Trust and The Institute of Cancer Research, Sutton, UK
    Int J Radiat Oncol Biol Phys 43:287-92. 1999
    ..To evaluate the efficacy and toxicity of accelerated radiotherapy in patients with primary high grade glioma, where acceleration is used as a means of delivering a shortened course of radical radiotherapy...

Research Grants50

  1. Prolong the Survival of NSCL Patients by a Phytomix
    Henry Sacks; Fiscal Year: 2006
    ..5 month and to 33.5 month respectively. SV was shown to be non-toxic, improved the Karnofsky Performance Status (KPS) and better maintained the patients' body weight...
  2. NABTT-Consortium Therapeutic Studies of CNS Malignancies
    Stuart Grossman; Fiscal Year: 2008
    ..abstract_text> ..
  3. NABTC - M.D. Anderson Clinical Center
    Mark Gilbert; Fiscal Year: 2008
    ..The NABTC continues with the long-term goal of developing more effective treatments for patients with primary brain tumors, particularly malignant gliomas, combining longevity with the quality of survival. ..
  4. NABTC CENTRAL OPERATION GRANT (UCSF PROJECT LEADER)
    Michael Prados; Fiscal Year: 2008
    ..The NABTC will treat patients using novel therapeutic agents with the ultimate goal to increase quality, and hopefully, overall survival in this patient population. ..
  5. CLINICAL TRIALS AND MENTORING IN ONCOLOGY RESEARCH
    Robert Motzer; Fiscal Year: 2003
    ..One recently joined staff at MSKCC in the Genito-urinary Section. Mentoring of clinical trials is extended beyond fellowship to junior faculty members. ..
  6. Molecular Basis Of Renal Cell Carcinoma Response to SU11428
    Robert J Motzer; Fiscal Year: 2011
    ..These tumor and cell line-based studies lay a foundation for further molecular studies aimed at understanding the sensitivity/resistance of RCC to SU11248. ..
  7. PEDIATRIC BRAIN TUMOR CLINICAL TRIAL CONSORTIUM
    Michael Prados; Fiscal Year: 2003
    ..The aim of these treatment approaches is to increase disease-free and overall survival in children with brain tumors. ..
  8. Use of HIT to Improve Symptom Mgt in Advanced Cancer
    Jean Kutner; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  9. Retinoids and Substances of Abuse in HIV-1 Infection
    Walter Royal; Fiscal Year: 2006
    ..These studies will broaden our understanding of the immune effects of retinoid compounds in individuals with HIV infection, and may lead to effective approaches to the treatment of the infection and its complications with vitamin A...
  10. Palliative Oxygen for the Relief of Breathlessness
    Amy Abernethy; Fiscal Year: 2007
    ..The results will also advance a long-standing international debate about the role of palliative oxygen for intractable dyspnea and it's funding. [unreadable] [unreadable] [unreadable]..
  11. NABTC Member Intitution Grant (UCSF Project Leader)
    Susan Chang; Fiscal Year: 2008
    ..The overall goal of this program is to more effectively treat patients with primary brain tumors, especially malignant glioma, with the purpose of increasing the duration and quality of survival. ..
  12. Modafinil Treatment for Fatigue in HIV+ Patients
    Judith Rabkin; Fiscal Year: 2008
    ..The major aims concern modafinil efficacy for fatigue compared to placebo, safety in terms of effects on immunologic/virologic measures, and impact on depressive symptoms when present at baseline. ..
  13. Creation and demonstration of a palliative care research cooperative group
    Jean S Kutner; Fiscal Year: 2010
    ....
  14. NATIONAL GENE VECTOR LABORATORY AT INDIANA UNIVERSITY
    Kenneth Cornetta; Fiscal Year: 2007
    ..abstract_text> ..
  15. A Decision Aid for Cancer-Surviving Adolescents
    Patricia Hollen; Fiscal Year: 2008
    ..Data will be collected during a semistructured interview for the initial and 12-month clinic visits. Generalized linear models will be used for data analyses. [unreadable] [unreadable] [unreadable]..
  16. Quantifying Cortical Neuron Production After Transplantation
    Lawrence Recht; Fiscal Year: 2008
    ..The ability to control the neuronal differentiation of these cells so that they can produce specific cell subsets should therefore be of great value in developing better therapeutic strategies for this problem. [unreadable] [unreadable]..
  17. Epigenetic Potentiation of Interferon using Decitabine
    Wolfram Samlowski; Fiscal Year: 2008
    ..Additional experiments will evaluate interferon signaling and DNA damage response pathways in normal and neoplastic cells. [unreadable] [unreadable] [unreadable]..
  18. Efficacy and toxicity of TRAIL against gliomas
    Vinay K Puduvalli; Fiscal Year: 2010
    ..The results of this study could also potentially provide a basis for clinical trials using TRAIL or analogues against gliomas and allow rational selection of agents to modulate the tumor resistance to TRAIL. ..
  19. Depression, Cytokines, and Pancreatic Cancer
    William Breitbart; Fiscal Year: 2006
    ..abstract_text> ..
  20. Analysis of Ethnic Admixture in Lung Cancer
    Jill Barnholtz Sloan; Fiscal Year: 2006
    ..These projects will give me experience in developing methodology in statistical genetics and genetic epidemiology, while also helping me to better understand etiology of disease. ..
  21. DESIRE FOR DEATH AMONG TERMINALLY ILL PATIENTS WITH AIDS
    William Breitbart; Fiscal Year: 2001
    ....
  22. Extracranial Stereotactic Radioablation in Lung Cancer
    Ronald McGarry; Fiscal Year: 2004
    ....
  23. DEPRESSION/DESIRE FOR DEATH IN TERMINAL CANCER PATIENTS
    William Breitbart; Fiscal Year: 2003
    ..This study is expected to provide a direct evaluation of desire for death in terminally ill cancer patients, and to ascertain whether a pharmacological treatment for depression influences desire for death. ..
  24. Management of Mucositis with GM-CSF
    Marylin Dodd; Fiscal Year: 2008
    ..abstract not provided ..
  25. DHEA EFFECTS ON MOOD IN DEPRESSED HIV+ PATIENTS
    Judith Rabkin; Fiscal Year: 2003
    ..This will permit the investigators to assess potential underlying mechanisms for the putative therapeutic effects of DHEA on mood, libido, and body composition. ..
  26. Stem Cell Plasticity after Blastocyst Implantation
    Lawrence Recht; Fiscal Year: 2004
    ..abstract_text> ..
  27. Meaning-Centered Psychotherapy in Advanced Cancer
    William Breitbart; Fiscal Year: 2002
    ..Larger, randomized controlled trials of Meaning-Centered Group Psychotherapy will be conducted in the future utilizing the insights learned from this pilot intervention study. ..
  28. APPROACHES TO BRAIN TUMOR THERAPY
    Steven Brem; Fiscal Year: 2002
    ....
  29. CDOn: A Novel Marker of Neuronal Stem Cells
    Lawrence Recht; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  30. DYING AT HOME OF AIDS & CANCER: PREFERENCES & OUTCOMES
    Judith Rabkin; Fiscal Year: 2004
    ..The data collected in the preliminary study will be used in the full-scale study. ..
  31. Correlative trial of fenretinide against Glioblastomas
    VINAY PUDUVALLI; Fiscal Year: 2003
    ..Such data could be relevant not only to future trials of retinoids in gliomas but also for ongoing trials of fenretinide in other malignancies. ..
  32. Cardiovascular Risk in Testicular Cancer Survivors
    David Vaughn; Fiscal Year: 2004
    ..However, prior to initiating an intervention study, these parameters need to be explicated. ..
  33. Phase II Study of 44Gy from 131I-81C6 for CNS Tumors
    David Reardon; Fiscal Year: 2004
    ..To further define the toxicity of this approach and Specific Aim 3.To determine the impact of this therapy on quality of life. ..
  34. Phase I trial of PHP with high-dose IL-2
    Wolfram Samlowski; Fiscal Year: 2006
    ..abstract_text> ..
  35. Real-time Minimal Residual Disease assay of Pediatric B-Cell Non-Hodgkin Lymphoma
    Bruce Shiramizu; Fiscal Year: 2007
    ..The assay developed by this exploratory proposal could be incorporated into pediatric B-cell NHL studies to assess MRD on therapy or to assess the efficacy of innovative therapies. [unreadable] [unreadable] [unreadable]..
  36. Function & Fate of Alloantigen-specific CD8 Cell in GVHD
    Paul Martin; Fiscal Year: 2005
    ..The studies proposed in this application will help clarify the critical functions and fate of specific donor CD8 cell population that cause GVHD. ..
  37. HIV-1 Proviral DNA and Monocyte Phenotype in Relation to Neurocognitive Function
    Bruce T Shiramizu; Fiscal Year: 2010
    ..This resource-rich team is well-positioned to conduct this investigation into the pathogenesis of HAD. ..
  38. Vitamins, Breast Milk HIV Shedding and Child Health
    Eduardo Villamor; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  39. Mycophenylate mofetil for treatment of chronic GVHD
    Paul Martin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  40. Electrocorticographic Study of Categorical Phoneme Perception in the Human Tempor
    Edward Chang; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  41. EXERCISE--AN INTERVENTION FOR FATIGUE IN CANCER PATIENTS
    Marylin Dodd; Fiscal Year: 2003
    ..The findings of this study will greatly assist in building this knowledge base. ..
  42. Predictive Markers of Glioblastoma Response to VEGF Trap
    John de Groot; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  43. The Impact of Lymphedema on Overall and Local Functioning
    Marylin Dodd; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  44. Changes in Functional Status Across Therapy for Primary Glioma
    Lee Jones; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  45. TEMPORALLY CONTROLLED DEPLETION OF ALLOREACTIVE T CELLS
    Paul Martin; Fiscal Year: 2002
    ..Results of these preclinical studies will help to assess the potential risks and benefits of using similar approaches to prevent GVHD in human marrow transplantation. ..
  46. MRI Study of Aggressive Individuals
    Ann Ragin; Fiscal Year: 2003
    ..Data obtained in this study will yield findings regarding brain structures potentially involved in impulsive aggression and provide insights concerning etiological factors in Intermittent Explosive Disorder. ..
  47. Activated Immune Parameters Associated with HIV & Aging
    Bruce Shiramizu; Fiscal Year: 2004
    ....
  48. A Diffusion Tensor Imaging Study of HIV-Dementia
    Ann Ragin; Fiscal Year: 2006
    ..Experience gained during the proposed award will lay the foundation for further independent investigations of neurobiological factors in HIV-D. ..
  49. Impact of Comorbidities on Outcomes of Allogeneic Transplantation
    Mohamed Sorror; Fiscal Year: 2008
    ..abstract_text> ..