severity of illness index


Summary: Levels of severity of illness within a diagnostic group which are established by various measurement criteria.

Top Publications

  1. ncbi Systemic lupus erythematosus disease activity index 2000
    Dafna D Gladman
    The University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Ontario, Canada
    J Rheumatol 29:288-91. 2002
  2. pmc The PHQ-9: validity of a brief depression severity measure
    K Kroenke
    Regenstrief Institute for Health Care and Department of Medicine, Indiana University, Indianapolis 46202, USA
    J Gen Intern Med 16:606-13. 2001
  3. ncbi Susceptibility to exacerbation in chronic obstructive pulmonary disease
    John R Hurst
    Academic Unit of Respiratory Medicine, Royal Free Campus, UCL Medical School, London, United Kingdom
    N Engl J Med 363:1128-38. 2010
  4. ncbi The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease
    Bartolome R Celli
    COPD Center at St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    N Engl J Med 350:1005-12. 2004
  5. pmc Treating rheumatoid arthritis to target: recommendations of an international task force
    Josef S Smolen
    Department of Internal Medicine 3, Division of Rheumatology, Medical University of Vienna, Waehringer Guertel 18 20, Vienna, Austria
    Ann Rheum Dis 69:631-7. 2010
  6. ncbi Global burden of COPD: risk factors, prevalence, and future trends
    David M Mannino
    Department of Preventive Medicine and Environmental Health, University of Kentucky College of Public Health, Lexington, KY 40536, USA
    Lancet 370:765-73. 2007
  7. ncbi Acute renal failure in critically ill patients: a multinational, multicenter study
    Shigehiko Uchino
    Department of Intensive Care, Austin Hospital, Melbourne, Australia
    JAMA 294:813-8. 2005
  8. ncbi Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis
    F D Lublin
    Department of Neurology, Jefferson Medical College, Philadelphia, PA, USA
    Neurology 46:907-11. 1996
  9. pmc Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study
    W S Lim
    Respiratory Infection Research Group, Respiratory Medicine, Nottingham City Hospital, Nottingham NG5 1PB, UK
    Thorax 58:377-82. 2003
  10. ncbi The 16-Item Quick Inventory of Depressive Symptomatology (QIDS), clinician rating (QIDS-C), and self-report (QIDS-SR): a psychometric evaluation in patients with chronic major depression
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9086, USA
    Biol Psychiatry 54:573-83. 2003

Detail Information

Publications320 found, 100 shown here

  1. ncbi Systemic lupus erythematosus disease activity index 2000
    Dafna D Gladman
    The University of Toronto Lupus Clinic, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, Ontario, Canada
    J Rheumatol 29:288-91. 2002
  2. pmc The PHQ-9: validity of a brief depression severity measure
    K Kroenke
    Regenstrief Institute for Health Care and Department of Medicine, Indiana University, Indianapolis 46202, USA
    J Gen Intern Med 16:606-13. 2001
    ..While considerable attention has focused on improving the detection of depression, assessment of severity is also important in guiding treatment decisions. Therefore, we examined the validity of a brief, new measure of depression severity...
  3. ncbi Susceptibility to exacerbation in chronic obstructive pulmonary disease
    John R Hurst
    Academic Unit of Respiratory Medicine, Royal Free Campus, UCL Medical School, London, United Kingdom
    N Engl J Med 363:1128-38. 2010
    ..In a large observational cohort, we tested the hypothesis that there is a frequent-exacerbation phenotype of COPD that is independent of disease severity...
  4. ncbi The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease
    Bartolome R Celli
    COPD Center at St Elizabeth s Medical Center, Tufts University School of Medicine, Boston, MA 02135, USA
    N Engl J Med 350:1005-12. 2004
    ..We hypothesized that a multidimensional grading system that assessed the respiratory and systemic expressions of COPD would better categorize and predict outcome in these patients...
  5. pmc Treating rheumatoid arthritis to target: recommendations of an international task force
    Josef S Smolen
    Department of Internal Medicine 3, Division of Rheumatology, Medical University of Vienna, Waehringer Guertel 18 20, Vienna, Austria
    Ann Rheum Dis 69:631-7. 2010
    ..Aiming at therapeutic targets has reduced the risk of organ failure in many diseases such as diabetes or hypertension. Such targets have not been defined for rheumatoid arthritis (RA)...
  6. ncbi Global burden of COPD: risk factors, prevalence, and future trends
    David M Mannino
    Department of Preventive Medicine and Environmental Health, University of Kentucky College of Public Health, Lexington, KY 40536, USA
    Lancet 370:765-73. 2007
    ..The challenge we will all face in the next few years will be implementation of cost-effective prevention and management strategies to stem the tide of this disease and its cost...
  7. ncbi Acute renal failure in critically ill patients: a multinational, multicenter study
    Shigehiko Uchino
    Department of Intensive Care, Austin Hospital, Melbourne, Australia
    JAMA 294:813-8. 2005
  8. ncbi Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis
    F D Lublin
    Department of Neurology, Jefferson Medical College, Philadelphia, PA, USA
    Neurology 46:907-11. 1996
    ..In this report, we provide a summary of the survey results and propose standardized definitions for the most common clinical courses of patients with MS...
  9. pmc Defining community acquired pneumonia severity on presentation to hospital: an international derivation and validation study
    W S Lim
    Respiratory Infection Research Group, Respiratory Medicine, Nottingham City Hospital, Nottingham NG5 1PB, UK
    Thorax 58:377-82. 2003
    ..A multicentre study was conducted to derive and validate a practical severity assessment model for stratifying adults hospitalised with CAP into different management groups...
  10. ncbi The 16-Item Quick Inventory of Depressive Symptomatology (QIDS), clinician rating (QIDS-C), and self-report (QIDS-SR): a psychometric evaluation in patients with chronic major depression
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9086, USA
    Biol Psychiatry 54:573-83. 2003
    ..The QIDS-SR(16) has highly acceptable psychometric properties, which supports the usefulness of this brief rating of depressive symptom severity in both clinical and research settings...
  11. ncbi General considerations for lung function testing
    M R Miller
    University Hospital Birmingham NHS Trust, UK
    Eur Respir J 26:153-61. 2005
  12. ncbi Coronary calcium as a predictor of coronary events in four racial or ethnic groups
    Robert Detrano
    Department of Radiological Sciences, University of California at Irvine, Irvine, CA 92697, USA
    N Engl J Med 358:1336-45. 2008
    ..However, it is not known whether coronary-artery calcium predicts coronary heart disease in other racial or ethnic groups...
  13. ncbi Epidemiology of insomnia: what we know and what we still need to learn
    Maurice M Ohayon
    Sleep Disorders Center, Stanford University School of Medicine, Stanford, CA 94305, USA
    Sleep Med Rev 6:97-111. 2002
    ..Future epidemiological studies should focus on the natural evolution of insomnia. Epidemiological genetic links of insomnia are yet to be studied...
  14. ncbi Physical activity in patients with COPD
    H Watz
    Pulmonary Research Institute Hospital Grosshansdorf, Center for Pneumology and Thoracic Surgery, Woehrendamm 80, Grosshansdorf, Germany
    Eur Respir J 33:262-72. 2009
    ..Clinical characteristics of patients with chronic obstructive pulmonary disease only incompletely reflect their physical activity...
  15. ncbi 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative
    Daniel Aletaha
    Arthritis Research UK, Copeman House, Chesterfield, UK
    Ann Rheum Dis 69:1580-8. 2010
    ..This work was undertaken to develop new classification criteria for RA...
  16. pmc Multidrug-resistant Plasmodium vivax associated with severe and fatal malaria: a prospective study in Papua, Indonesia
    Emiliana Tjitra
    National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia
    PLoS Med 5:e128. 2008
    ..The aim of the study was to review the spectrum of disease associated with malaria due to Pv and P. falciparum (Pf) in patients presenting to a hospital in Timika, southern Papua, Indonesia...
  17. ncbi A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C
    Chun Tao Wai
    Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Hepatology 38:518-26. 2003
    ..Application of this index may decrease the need for staging liver biopsy specimens among CHC patients...
  18. ncbi Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health
    Richard P Allen
    Department of Neurology, Sleep Medicine, Johns Hopkins Bayview Medical Center, Asthma and Allergy Building 1B46b, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Sleep Med 4:101-19. 2003
    ..Modification of the criteria is now necessary to better reflect that increased body of knowledge, as well as to clarify slight confusion with the wording of the original criteria...
  19. pmc Plasmodium vivax and mixed infections are associated with severe malaria in children: a prospective cohort study from Papua New Guinea
    Blaise Genton
    Swiss Tropical Institute, Basel, Switzerland
    PLoS Med 5:e127. 2008
    ..A large morbidity surveillance conducted in an area where the four species coexist allowed us to estimate rates of SM among patients infected with one or several species...
  20. ncbi Infections and airway inflammation in chronic obstructive pulmonary disease severe exacerbations
    Alberto Papi
    Research Center on Asthma and COPD, Department of Respiratory Diseases, University of Modena and Reggio Emilia, Via del Pozzo 71, I 41100 Modena, Italy
    Am J Respir Crit Care Med 173:1114-21. 2006
    ..Severe exacerbations of chronic obstructive pulmonary disease (COPD) are major causes of health care costs mostly related to hospitalization. The role of infections in COPD exacerbations is controversial...
  21. pmc Development, validity and responsiveness of the Clinical COPD Questionnaire
    Thys van der Molen
    Department of General Practice, University of Groningen, Groningen, The Netherlands
    Health Qual Life Outcomes 1:13. 2003
    ..So far no validated questionnaires are available to measure symptom and functional state in daily clinical practice. The aim of this study was to develop and validate the Clinical COPD Questionnaire (CCQ)...
  22. ncbi The pathophysiology of vivax malaria
    Nicholas M Anstey
    International Health Division, Menzies School of Health Research and Charles Darwin University, Darwin 0810, Australia
    Trends Parasitol 25:220-7. 2009
    ..In this review, we discuss potential mechanisms underlying the syndromes of uncomplicated and severe vivax malaria, identifying key areas for future research...
  23. ncbi The relationship between reduced lung function and cardiovascular mortality: a population-based study and a systematic review of the literature
    Don D Sin
    Department of Medicine, Respiratory Division, University of British Columbia, and The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 368A, 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada
    Chest 127:1952-9. 2005
    ..We sought to determine the relationship between reduced FEV1 and cardiovascular mortality, independent of smoking...
  24. ncbi Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales
    C P Wilkinson
    Greater Baltimore Medical Center, Baltimore, Maryland, USA
    Ophthalmology 110:1677-82. 2003
  25. pmc Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study
    G Jones
    Menzies Research Institute, University of Tasmania, Hobart, TAS 7001, Australia
    Ann Rheum Dis 69:88-96. 2010
    ..The anti-interleukin (IL) 6 receptor antibody tocilizumab inhibits signalling of IL6, a key cytokine in rheumatoid arthritis (RA) pathogenesis...
  26. ncbi A comparison of the EQ-5D and SF-6D across seven patient groups
    John Brazier
    Sheffield Health Economics Group, University of Sheffield, Sheffield, UK
    Health Econ 13:873-84. 2004
    ..Further research is required to fully understand the respective roles of the descriptive systems and the valuation methods and to examine the implications for estimates of the impact of health care interventions...
  27. ncbi Properties of the COPD assessment test in a cross-sectional European study
    P W Jones
    Division of Clinical Science, St George s University of London, Cranmer Terrace, London SW17 0RE, UK
    Eur Respir J 38:29-35. 2011
    ..8, p<0.0001). The CAT is a simple and easy-to-use questionnaire that distinguishes between patients of different degrees of COPD severity and appears to behave the same way across countries...
  28. ncbi Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study
    Debra E Irwin
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, United States
    Eur Urol 50:1306-14; discussion 1314-5. 2006
    ..Estimate the prevalence of urinary incontinence (UI), overactive bladder (OAB), and other lower urinary tract symptoms (LUTS) among men and women in five countries using the 2002 International Continence Society (ICS) definitions...
  29. pmc Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care
    G Peat
    Primary Care Sciences Research Centre, Keele University, UK
    Ann Rheum Dis 60:91-7. 2001
    ..Osteoarthritis is the single most common cause of disability in older adults, and most patients with the condition will be managed in the community and primary care...
  30. ncbi Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection
    Richard K Sterling
    Section of Hepatology, Virginia Commonwealth University Health System, Richmond, VA 23298 0341, USA
    Hepatology 43:1317-25. 2006
    ..In conclusion, noninvasive tests can accurately predict hepatic fibrosis and may reduce the need for liver biopsy in the majority of HIV/HCV-coinfected patients...
  31. ncbi Prevalence of chronic obstructive pulmonary disease in China: a large, population-based survey
    Nanshan Zhong
    Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital, Guangzhou Medical College, 151 Yanjiang Road, Guangzhou, Guangdong 510120, China
    Am J Respir Crit Care Med 176:753-60. 2007
    ..The prevalence of chronic obstructive pulmonary disease (COPD) in China is largely unknown...
  32. ncbi Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease
    J Blacher
    Service de Medecine Interne, Hopital Broussais, AP HP, Paris, France
    Hypertension 38:938-42. 2001
    ..01 for both). The results of this study showed that the presence and extent of vascular calcifications were strong predictors of cardiovascular and all-cause mortality. Carotid incremental elastic modulus gave additional predictive value...
  33. pmc Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration
    Irving Kirsch
    Department of Psychology, University of Hull, Hull, United Kingdom
    PLoS Med 5:e45. 2008
    ..The purpose of this analysis is to establish the relation of baseline severity and antidepressant efficacy using a relevant dataset of published and unpublished clinical trials...
  34. pmc Estimation of the total parasite biomass in acute falciparum malaria from plasma PfHRP2
    Arjen M Dondorp
    Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
    PLoS Med 2:e204. 2005
    ..P. falciparum releases a specific histidine-rich protein (PfHRP2) into plasma. Quantitative measurement of plasma PfHRP2 concentrations may reflect the total parasite biomass in falciparum malaria...
  35. ncbi Obesity and the metabolic syndrome in children and adolescents
    Ram Weiss
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    N Engl J Med 350:2362-74. 2004
  36. pmc Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis
    Fernando A Bozza
    ICU, Instituto de Pesquisa Clinica Evandro Chagas, Fundacao Oswaldo Cruz, Av Brasil 4365, Rio de Janeiro, Brazil
    Crit Care 11:R49. 2007
    ..The aim of the present study was to determine the cytokine profile in plasma of patients with severe sepsis by using a multiplex system for simultaneous detection of 17 cytokines...
  37. pmc Usefulness and applicability of the revised dengue case classification by disease: multi-centre study in 18 countries
    Judit Barniol
    Section Clinical Tropical Medicine, Department for Infectious Diseases, University Hospital Heidelberg, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany
    BMC Infect Dis 11:106. 2011
    ..The objective of this paper was to compare the two classification systems regarding applicability in clinical practice and surveillance, as well as user-friendliness and acceptance by health staff...
  38. ncbi Multiple Sclerosis Severity Score: using disability and disease duration to rate disease severity
    R H S R Roxburgh
    Neurology Department, Cambridge University, UK
    Neurology 64:1144-51. 2005
    ..There is no consensus method for determining progression of disability in patients with multiple sclerosis (MS) when each patient has had only a single assessment in the course of the disease...
  39. ncbi Effect of tiotropium on outcomes in patients with moderate chronic obstructive pulmonary disease (UPLIFT): a prespecified subgroup analysis of a randomised controlled trial
    Marc Decramer
    Respiratory Division, University of Leuven, Leuven, Belgium
    Lancet 374:1171-8. 2009
    ..However, there are few data for treatment in the early stages of the disease. We examined the effect of tiotropium on outcomes in a large subgroup of patients with moderate COPD...
  40. ncbi Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease?
    C Y Cheung
    Department of Microbiology, University of Hong Kong, Queen Mary Hospital, SAR, Hong Kong, China
    Lancet 360:1831-7. 2002
    ..The biological basis for the severity of human H5N1 disease has remained unclear. We tested the hypothesis that virus-induced cytokine dysregulation has a role...
  41. ncbi Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials
    Peter M A Calverley
    School of Clinical Sciences, Liverpool, UK
    Lancet 374:685-94. 2009
    ..We therefore investigated whether roflumilast would reduce the frequency of exacerbations requiring corticosteroids in patients with COPD...
  42. ncbi Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers
    Mona Bafadhel
    Institute for Lung Health, University of Leicester, Leicester, United Kingdom
    Am J Respir Crit Care Med 184:662-71. 2011
    ..Exacerbations of chronic obstructive pulmonary disease (COPD) are heterogeneous with respect to inflammation and etiology...
  43. pmc Evaluation of the traditional and revised WHO classifications of Dengue disease severity
    Federico Narvaez
    Infectious Diseases Unit, Hospital Infantil Manuel de Jesus Rivera, Managua, Nicaragua
    PLoS Negl Trop Dis 5:e1397. 2011
  44. pmc Genome-wide and fine-resolution association analysis of malaria in West Africa
    Muminatou Jallow
    MRC Laboratories, Fajara, Banjul, Gambia
    Nat Genet 41:657-65. 2009
  45. ncbi Diagnostic performance of coronary angiography by 64-row CT
    Julie M Miller
    Johns Hopkins University School of Medicine, Baltimore 21287, USA
    N Engl J Med 359:2324-36. 2008
    ..The accuracy of multidetector computed tomographic (CT) angiography involving 64 detectors has not been well established...
  46. pmc Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza
    Jesus F Bermejo-Martin
    National Centre of Influenza, Hospital Clinico Universitario de Valladolid, Valladolid, Spain
    Crit Care 13:R201. 2009
    ..We utilize here systemic cytokine and antibody levels in evaluating differences in early immune response in both mild and severe patients infected with nvH1N1...
  47. pmc Prediction of risk of death and myocardial infarction in the six months after presentation with acute coronary syndrome: prospective multinational observational study (GRACE)
    Keith A A Fox
    Royal Infirmary of Edinburgh, University of Edinburgh, Edinburgh EH16 4SB
    BMJ 333:1091. 2006
    ..To develop a clinical risk prediction tool for estimating the cumulative six month risk of death and death or myocardial infarction to facilitate triage and management of patients with acute coronary syndrome...
  48. ncbi Hyponatremia and mortality among patients on the liver-transplant waiting list
    W Ray Kim
    Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    N Engl J Med 359:1018-26. 2008
    ..Under the current liver-transplantation policy, donor organs are offered to patients with the highest risk of death...
  49. ncbi Performance of transient elastography for the staging of liver fibrosis: a meta-analysis
    Mireen Friedrich-Rust
    Department of Internal Medicine I, J W Goethe University Hospital, Frankfurt, Germany
    Gastroenterology 134:960-74. 2008
    ..A meta-analysis was performed to assess the overall performance of transient elastography for the diagnosis of liver fibrosis and to analyze factors influencing the diagnostic accuracy...
  50. ncbi American College of Rheumatology/European League against Rheumatism provisional definition of remission in rheumatoid arthritis for clinical trials
    David T Felson
    Correspondence to Maarten Boers, Department of Epidemiology and Biostatistics, VU University Medical Center, PK 6Z 165, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Ann Rheum Dis 70:404-13. 2011
    ..This work was undertaken to develop such a definition...
  51. ncbi Serial evaluation of the SOFA score to predict outcome in critically ill patients
    F L Ferreira
    Department of Intensive Care, Erasme University Hospital, Route de Lennik, 808, B 1070 Brussels, Belgium
    JAMA 286:1754-8. 2001
    ..Evaluation of trends in organ dysfunction in critically ill patients may help predict outcome...
  52. ncbi Viral respiratory infections in hospitalized and community control children in Alaska
    Rosalyn J Singleton
    Alaska Native Tribal Health Consortium, Anchorage, Alaska
    J Med Virol 82:1282-90. 2010
    ..Rhinovirus and adenovirus were detected in two-thirds of hospitalized children, but their frequent detection in control children made their role in respiratory hospitalization uncertain...
  53. ncbi Mild cognitive impairment
    Serge Gauthier
    McGill Center for Studies in Aging, Douglas Hospital, Montreal, Quebec, Canada
    Lancet 367:1262-70. 2006
    ..Other definitions and subtypes of mild cognitive impairment need to be studied as potential prodromes of Alzheimer's disease and other types of dementia...
  54. ncbi Definition, epidemiology and natural history of COPD
    G Viegi
    CNR Institute of Clinical Physiology, Via Trieste 41, 56126, Pisa, Italy
    Eur Respir J 30:993-1013. 2007
    ..Smoking prevention and smoking cessation are the most important epidemiological measurements to counteract chronic obstructive pulmonary disease epidemics...
  55. ncbi Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial
    Sandra V Navarra
    University of Santo Tomas Hospital, Manila, Philippines
    Lancet 377:721-31. 2011
    ..The efficacy and safety of the fully human monoclonal antibody belimumab (BLyS-specific inhibitor) was assessed in patients with active systemic lupus erythematosus...
  56. ncbi COPD exacerbations: defining their cause and prevention
    Jadwiga A Wedzicha
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School University College London, UK
    Lancet 370:786-96. 2007
  57. pmc Severe Plasmodium vivax malaria exhibits marked inflammatory imbalance
    Bruno B Andrade
    Centro de Pesquisas Gonçalo Moniz CPqGM, Fundação Oswaldo Cruz FIOCRUZ, Salvador, Bahia, Brazil
    Malar J 9:13. 2010
    ..In this report, the inflammatory and immunological status of both mild and severe vivax malaria cases are compared in order to explore immunopathological events in this disease...
  58. ncbi Validation of a modified Early Warning Score in medical admissions
    C P Subbe
    Department of Medicine, Wrexham Maelor Hospital, Wrexham, UK
    QJM 94:521-6. 2001
    ..A clinical pathway could be created, using nurse practitioners and/or critical care physicians, to respond to high scores and intervene with appropriate changes in clinical management...
  59. ncbi Model for end-stage liver disease (MELD) and allocation of donor livers
    Russell Wiesner
    Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Gastroenterology 124:91-6. 2003
    ..Our aim was to assess the capability of the Model for End-Stage Liver Disease (MELD) score to correctly rank potential liver recipients according to their severity of liver disease and mortality risk on the OPTN liver waiting list...
  60. ncbi Annual change in pulmonary function and clinical phenotype in chronic obstructive pulmonary disease
    Masaharu Nishimura
    First Department of Medicine, Hokkaido University School of Medicine, and Center for Respiratory Diseases, Hokkaido Social Insurance Hospital, N 15 W 7, Kita ku, Sapporo 060 8638, Japan
    Am J Respir Crit Care Med 185:44-52. 2012
    ..Although the rate of annual decline in FEV1 is one of the most important outcome measures in chronic obstructive pulmonary disease (COPD), little is known about intersubject variability based on clinical phenotypes...
  61. ncbi Sampling variability of liver biopsy in nonalcoholic fatty liver disease
    Vlad Ratziu
    Service d Hepatogastroenterologie, Groupe Hospitalier Pitie Salpetriere, Paris, France
    Gastroenterology 128:1898-906. 2005
    ..The aim of this study was to assess the sampling error of liver biopsy and its impact on the diagnosis and staging of NASH...
  62. ncbi Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials
    Leonardo M Fabbri
    University of Modena and Reggio Emilia, Modena, Italy
    Lancet 374:695-703. 2009
    ..The effect of roflumilast on lung function in patients with COPD that is moderate to severe who are already being treated with salmeterol or tiotropium was investigated...
  63. ncbi Use of the SOFA score to assess the incidence of organ dysfunction/failure in intensive care units: results of a multicenter, prospective study. Working group on "sepsis-related problems" of the European Society of Intensive Care Medicine
    J L Vincent
    Department of Intensive Care, Erasme University Hospital, Brussels, Belgium
    Crit Care Med 26:1793-800. 1998
    ..To evaluate the use of the Sequential Organ Failure Assessment (SOFA) score in assessing the incidence and severity of organ dysfunction in critically ill patients...
  64. ncbi Increased risk of myocardial infarction and stroke following exacerbation of COPD
    Gavin C Donaldson
    Academic Unit of Respiratory Medicine, Royal Free and University College Medical School, University College London, Rowland Hill Street, London, NW3 2PF, England
    Chest 137:1091-7. 2010
    ..The course of COPD is punctuated by exacerbations, which further increase systemic inflammation, but the risk of vascular events in the postexacerbation period has never been defined...
  65. pmc Physical inactivity in patients with COPD, a controlled multi-center pilot-study
    Thierry Troosters
    Pulmonary Rehabilitation and Respiratory Division, UZ Gasthuisberg, Leuven, Belgium
    Respir Med 104:1005-11. 2010
    ..Studies in moderate COPD are currently scarce. The aim of the present study was to investigate physical activity in daily life in patients with COPD (n=70) and controls (n=30)...
  66. ncbi Validation of the National Institutes of Health consensus definition of bronchopulmonary dysplasia
    Richard A Ehrenkranz
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Pediatrics 116:1353-60. 2005
    ..The objective of this study was to determine the predictive validity of the severity-based, consensus definition of BPD...
  67. ncbi Dyspnea is a better predictor of 5-year survival than airway obstruction in patients with COPD
    Koichi Nishimura
    Respiratory Division, Kyoto Katsura Hospital, Kyoto, Japan
    Chest 121:1434-40. 2002
  68. pmc Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study
    Michael Bennett
    Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, University of Cincinnati School of Medicine, Cincinnati, OH 45229 3039, USA
    Clin J Am Soc Nephrol 3:665-73. 2008
    ..In this study, whether an NGAL immunoassay developed for a standardized clinical platform (ARCHITECT analyzer, Abbott Diagnostics Division, Abbott Laboratories, Abbott Park, IL) can predict AKI after CPB was tested...
  69. ncbi Ethnic differences in coronary calcification: the Multi-Ethnic Study of Atherosclerosis (MESA)
    Diane E Bild
    Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    Circulation 111:1313-20. 2005
  70. ncbi Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE)
    J Vestbo
    Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark
    Eur Respir J 31:869-73. 2008
  71. ncbi Obstructive and restrictive lung disease and markers of inflammation: data from the Third National Health and Nutrition Examination
    David M Mannino
    Air Pollution and Respiratory Health Branch, Division of Environmental Hazards and Health Effects, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Am J Med 114:758-62. 2003
  72. ncbi A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile-associated diarrhea, stratified by disease severity
    Fred A Zar
    University of Illinois at Chicago, Chicago, IL 60612 7323, USA
    Clin Infect Dis 45:302-7. 2007
    ..We conducted such a trial, stratifying patients according to disease severity, to investigate whether one agent was superior for treating either mild or severe disease...
  73. pmc Dengue--how best to classify it
    Anon Srikiatkhachorn
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Clin Infect Dis 53:563-7. 2011
    ..The 2009 classification differs significantly from the previous classification in both conceptual and practical levels. The impacts of the new classification on clinical practice, dengue research, and public health policy are discussed...
  74. ncbi The progression of chronic obstructive pulmonary disease is heterogeneous: the experience of the BODE cohort
    Ciro Casanova
    Pulmonary Department, Hospital Universitario La Candelaria, Tenerife, Spain
    Am J Respir Crit Care Med 184:1015-21. 2011
    ..Chronic obstructive pulmonary disease (COPD) is thought to result in rapid and progressive loss of lung function usually expressed as mean values for whole cohorts...
  75. pmc Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: a meta-analysis
    F G R Fowkes
    JAMA 300:197-208. 2008
    ..Prediction models to identify healthy individuals at high risk of cardiovascular disease have limited accuracy. A low ankle brachial index (ABI) is an indicator of atherosclerosis and has the potential to improve prediction...
  76. ncbi Further evidence supporting an SEM-based criterion for identifying meaningful intra-individual changes in health-related quality of life
    K W Wyrwich
    Saint Louis University School of Public Health, Missouri 63108 3342, USA
    J Clin Epidemiol 52:861-73. 1999
    ..The one-SEM criterion should be explored in other health-related quality of life instruments with established MCIDs...
  77. ncbi What does the PANSS mean?
    Stefan Leucht
    Klinik für Psychiatrie und Psychotherapie der TU München Klinikum rechts der Isar, Ismaningerstr 22, 81675 Munchen, Germany
    Schizophr Res 79:231-8. 2005
    ..g. at least 20% or 50% reduction of the baseline score) are as yet unclear. We therefore compared the PANSS with simultaneous ratings of Clinical Global Impressions (CGI)...
  78. ncbi Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes
    Anna Ludovica Fracanzani
    Department of Internal Medicine, Scientific Institute of Recovery and Cure Foundation IRCCS, Hospital Maggiore Policlinico, University of Milan, Milan, Italy
    Hepatology 48:792-8. 2008
    ..07; 95% CI, 1.02-1.14), and diabetes (OR, 1.8; 95% CI, 1.4-2.3) in the overall series, serum ferritin and diabetes in those with increased ALT, and only HOMA-IR (OR, 1.97; 95% CI, 1.2-3.7) in patients with normal ALT...
  79. ncbi The Multiple Sclerosis Impact Scale (MSIS-29): a new patient-based outcome measure
    J Hobart
    Neurological Outcome Measures Unit, Institute of Neurology, London, UK
    Brain 124:962-73. 2001
    ..These results indicate the MSIS-29 is a clinically useful and scientifically sound patient-based outcome measure of the impact of multiple sclerosis suitable for clinical trials and epidemiological studies...
  80. ncbi Time trends and impact of upper and lower gastrointestinal bleeding and perforation in clinical practice
    Angel Lanas
    Servicio de Aparato Digestivo, Hospital Clinico, Universidad de Zaragoza, Zaragoza, Spain
    Am J Gastroenterol 104:1633-41. 2009
  81. pmc Use of mental health services for anxiety, mood, and substance disorders in 17 countries in the WHO world mental health surveys
    Philip S Wang
    Division of Services and Intervention Research, National Institute of Mental Health, Rockville, MD, USA
    Lancet 370:841-50. 2007
    ..We describe mental health care in 17 countries participating in the WHO world mental health (WMH) survey initiative and examine unmet needs for treatment...
  82. ncbi Intergenerational transmission of subthreshold autistic traits in the general population
    John N Constantino
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Biol Psychiatry 57:655-60. 2005
    ..Subthreshold autistic social impairments are known to aggregate in the family members of autistic probands; therefore, we conducted this study to examine the intergenerational transmission of such traits in the general population...
  83. ncbi Predictors of relapse following response from a first episode of schizophrenia or schizoaffective disorder
    D Robinson
    Department of Psychiatry, Hillside Hospital, Long Island Jewish Medical Center, Glen Oaks, NY 11004, USA
    Arch Gen Psychiatry 56:241-7. 1999
    ..We examined relapse after response to a first episode of schizophrenia or schizoaffective disorder...
  84. ncbi A simplified disease activity index for rheumatoid arthritis for use in clinical practice
    J S Smolen
    University of Vienna and Lainz Hospital, Austria
    Rheumatology (Oxford) 42:244-57. 2003
    ..The objective of this study was to verify the usefulness of a simple disease activity index (SDAI) for rheumatoid arthritis (RA)...
  85. ncbi Practice parameters for the indications for polysomnography and related procedures: an update for 2005
    Clete A Kushida
    Stanford University Center of Excellence for Sleep Disorders, Stanford, CA, USA
    Sleep 28:499-521. 2005
  86. ncbi Systematic review of the psychometric properties, interpretability and feasibility of self-report pain intensity measures for use in clinical trials in children and adolescents
    Jennifer N Stinson
    Faculty of Nursing, University of Toronto, Hospital for Sick Children, Toronto, Ont, Canada
    Pain 125:143-57. 2006
    ..Future research is needed to strengthen the measurement of pain in clinical trials with children...
  87. pmc Validation of the 28-joint Disease Activity Score (DAS28) and European League Against Rheumatism response criteria based on C-reactive protein against disease progression in patients with rheumatoid arthritis, and comparison with the DAS28 based on erythr
    G Wells
    Department of Epidemiology and Community Medicine, University of Ottawa, Canada
    Ann Rheum Dis 68:954-60. 2009
    ..To validate and compare the definition of the Disease Activity Score 28 based on C-reactive protein (DAS28 (CRP)) to the definition based on erythrocyte sedimentation rate (ESR)...
  88. ncbi The COPD assessment test (CAT): response to pulmonary rehabilitation. A multicentre, prospective study
    James W Dodd
    St George s Hospital NHS Trust, London, UK
    Thorax 66:425-9. 2011
    ..It is not known how the CAT score performs in the context of clinical pulmonary rehabilitation (PR) programmes or what the minimum clinically important difference is...
  89. ncbi Subthreshold depression in adolescence and mental health outcomes in adulthood
    David M Fergusson
    Christchurch Health and Development Study, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Arch Gen Psychiatry 62:66-72. 2005
    ..There is increasing interest in the extent to which individuals with subthreshold depression face increased risks of subsequent major depression and other disorders...
  90. ncbi The WHO dengue classification and case definitions: time for a reassessment
    Jacqueline L Deen
    International Vaccine Institute, Kwanak PO Box 14, Seoul, Republic of Korea
    Lancet 368:170-3. 2006
  91. ncbi Prevalence of kidney damage in Australian adults: The AusDiab kidney study
    Steven J Chadban
    Department of Nephrology, Monash Medical Centre, USA
    J Am Soc Nephrol 14:S131-8. 2003
    ..Identifying and targeting this section of the population may provide a means to reduce the burden of ESRD...
  92. ncbi Worldwide severity and control of asthma in children and adults: the global asthma insights and reality surveys
    Klaus F Rabe
    Department of Pulmonology, Leiden University Medical Center, Leiden, The Netherlands
    J Allergy Clin Immunol 114:40-7. 2004
    ..In 1995, the Global Initiative for Asthma (GINA) guidelines recommended goals for the management of asthma, which were updated in 2002. However, there are no recent international surveys on the real management of asthma...
  93. ncbi Comparison of clinical severity score indices for Clostridium difficile infection
    Shigeki Fujitani
    Division of Infectious Diseases, Cedars Sinai Medical Center, Los Angeles, California, USA
    Infect Control Hosp Epidemiol 32:220-8. 2011
    ..To compare 8 severity score indices for Clostridium difficile infection (CDI)...
  94. pmc Chronic obstructive pulmonary disease exacerbations in the COPDGene study: associated radiologic phenotypes
    MeiLan K Han
    Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Radiology 261:274-82. 2011
  95. ncbi Strategies of muscle training in very severe COPD patients
    I Vogiatzis
    Department of Physical Education and Sport Sciences, National and Kapodistrian University of Athens, Athens, Greece
    Eur Respir J 38:971-5. 2011
  96. ncbi No health without mental health
    Martin Prince
    King s College London, Centre for Public Mental Health, Health Service and Population Research Department, Institute of Psychiatry, London, UK
    Lancet 370:859-77. 2007
    ..Mental health awareness needs to be integrated into all aspects of health and social policy, health-system planning, and delivery of primary and secondary general health care...
  97. pmc Intensive care adult patients with severe respiratory failure caused by Influenza A (H1N1)v in Spain
    Jordi Rello
    Critical Care Department, Joan XXIII University Hospital, CIBERes Enfermedades Respiratorias, IISPV, Mallafre Guasch 4, 43007 Tarragona, Spain
    Crit Care 13:R148. 2009
    ..We describe the clinical and epidemiologic characteristics of the first 32 persons reported to be admitted to the intensive care unit (ICU) due to influenza A (H1N1)v infection in Spain...
  98. ncbi Practice guidelines in acute pancreatitis
    Peter A Banks
    Division of Gastroenterology, Center for Pancreatic Disease, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Gastroenterol 101:2379-400. 2006
  99. pmc Plasma IP-10, apoptotic and angiogenic factors associated with fatal cerebral malaria in India
    Vidhan Jain
    National Institute of Malaria Research ICMR, Jabalpur, India
    Malar J 7:83. 2008
  100. ncbi Prevalence, treatment, and associated disability of mental disorders in four provinces in China during 2001-05: an epidemiological survey
    Michael R Phillips
    WHO Collaborating Centre for Research and Training in Suicide Prevention, Beijing Hui Long Guan Hospital, Beijing, China
    Lancet 373:2041-53. 2009
    ..We therefore estimated these variables from a series of epidemiological studies that were done in four provinces in China...
  101. ncbi Severe Plasmodium vivax malaria: a report on serial cases from Bikaner in northwestern India
    Dhanpat K Kochar
    Department of Medicine, S P Medical College, Bikaner, Rajasthan, India
    Am J Trop Med Hyg 80:194-8. 2009
    ..5%) patients, and multi-organ dysfunction was detected in 19 (47.5%) patients. Further large-scale multicentric epidemiologic studies are needed to define the basic pathology of this less known entity...

Research Grants102 found, 100 shown here

  1. PRIDE: Program to Reduce Incontinence by Diet & Exercise
    Rena Wing; Fiscal Year: 2007
    ..If effective in womenwith incontinence, the methods and strategies of this innovative motivationally-focusedmaintenance intervention can beexamined n other obese populations. ..
  2. TeleCare Management of Pain and Depression in Cancer
    Kurt Kroenke; Fiscal Year: 2009
    ..Furthermore, if proven effective for depression and pain, TCM could readily be expanded to reducing barriers and improving care of other cancer-related symptoms. ..
  3. Mechanisms for Hormone-Dependent NF-kB Activation
    Allan Brasier; Fiscal Year: 2007
    ..These studies will identify new therapeutic targets that can disrupt the vicious cycle of inflammation and atherosclerosis. ..
    Allan Brasier; Fiscal Year: 2006
    ..Expression of dominant-negative NF-KB and CBP/p300 coactivators will be used to determine their effect on coactivator recruitment. These studies will identify signaling mechanisms and protein interactions in viral-induced inflammation. ..
  5. Genetics of Asthma Severity and Lung Function Decline
    Nadia Hansel; Fiscal Year: 2008
    ..Hansel new knowledge, skills and collaborative relationships necessary to successfully apply for funding as an independent investigator during the fourth year of this award. ..
    Hermine Brunner; Fiscal Year: 2007
    ..Abstract Not Provided ..
    Katherine Watkins; Fiscal Year: 2008
    ..At the end of this pilot, we will have a manualized intervention, sufficient data to estimate the intervention effect size, and a well-described process for involving providers and clients. [unreadable] [unreadable] [unreadable]..
  8. Understanding the Impact of Multiple Symptoms: A Symptom Burden Consortium
    Charles Cleeland; Fiscal Year: 2006
    ..The document will be a collaborative effort among consortium participants, and will be submitted to a leading scientific peer-reviewed journal. [unreadable] [unreadable] [unreadable] [unreadable]..
    Robert Freedman; Fiscal Year: 2009
    Katherine Watkins; Fiscal Year: 2009
    ..abstract_text> ..
  11. Mechanisms and Treatment of Cancer-Related Symptoms Conf
    Charles Cleeland; Fiscal Year: 2005
    ..The conference should also be of interest to pharmaceutical companies that are developing "pipeline" drugs for symptom control and supportive care. ..
  12. Mental Practice Dosing and Mechanisms in Stroke
    Stephen Page; Fiscal Year: 2006
    ..Identification of MP mechanisms of action and optimal dosing is fundamental to cost-effective, appropriate implementation of this promising, CAM, mind-body technique, and will enable a subsequent MP clinical trial. ..
  13. Sleep Disturbance in Menopause
    Robert Freedman; Fiscal Year: 2006
    ..In Study 5, we will determine the effects of elevated sympathetic activation on HFs and sleep using a stimulus that does not, by itself, disrupt sleep (orthostasis). ..
  14. Pramipexole in Treatment-Resistant Depression
    Roy Perlis; Fiscal Year: 2007
    ..The proposed investigation and training program will provide critical skills, experience and data to aid the candidate in writing an R01 and becoming an independent investigator. ..
  15. Genetics of Suscptibility to Anthrax Toxin in vivo
    Cory Teuscher; Fiscal Year: 2008
    ..abstract_text> ..
    Edna Foa; Fiscal Year: 2008
    ..Therefore the findings from this study will be highly credible and should impact significantly on treatment recommendations for this impaired population. ..
  17. How Health Insurance Status Affects Persons with Disabilities
    Lisa Iezzoni; Fiscal Year: 2007
    ..This goal addresses the objectives of the Agency for Healthcare Research and Quality, which has identified persons with disabilities as one of its priority populations. [unreadable] [unreadable] [unreadable]..
  18. Early-Stage Breast Cancer Treatment Decisions by Women with Physical Disabilities
    Lisa Iezzoni; Fiscal Year: 2007
    ..Our findings will help begin educating patients and physicians and could perhaps improve breast cancer care for women with physical disabilities. [unreadable] [unreadable] [unreadable]..
  19. Antidepressant & CBT for Insomnia to Depression Outcome
    Rachel Manber; Fiscal Year: 2006
    ..The findings from the proposed pilot study will inform the design of a subsequent full-scale randomized controlled trial. ..
  20. Cancer Care and Outcomes for Disabled Medicare Patients
    Lisa Iezzoni; Fiscal Year: 2006
    ..These findings may suggest areas where more attention is needed, such as increasing cancer screening among disabled Medicare recipients or rethinking initial treatment strategies. ..
  21. Opioid Prescribing Patterns in the U.S.
    Mark Pletcher; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  22. Pleasant Events and Moods: A Time-Series Analysis
    Brent Mausbach; Fiscal Year: 2006
    ..The remaining participants will receive no feedback. All participants will receive a one-month follow-up to determine if those receiving detailed feedback experience fewer negative emotions and more positive emotions. ..
  23. Revision of ACR Classification Criteria for Systemic Lupus Erythematosus
    Michelle Petri; Fiscal Year: 2007
    ..This project will lead to updated, validated SLE classification criteria that can be immediately used by both industry and academic clinical trials. ..
  24. Brain Connections
    Michelle Petri; Fiscal Year: 2006
    ..abstract_text> ..
    Rachel Manber; Fiscal Year: 2006
    ..Other important measures include the Beck Depression Inventory (weekly), expectations (of the participants and the providers), and delivery and infant measures. ..
  26. Treating Addiction to Sleep Medication
    Kenneth Lichstein; Fiscal Year: 2008
    ..This project fits within the guidelines of a Stage II clinical trial according to the Behavioral Therapies Development Program of the National Institute on Drug Abuse. ..
  27. Efficacy of a Health Intervention for People with Intellectual Disabilities
    Willi Horner Johnson; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
    Michael Stein; Fiscal Year: 2007
    ..If effective, this brief alcohol intervention can be readily integrated into existing programs for incarcerated women who will soon be reintegrating into the community. ..
    Michael Stein; Fiscal Year: 2009
    ..Our research team is highly experienced in drug research, sleep disorders, and clinical trials in substance abusing populations. ..
  30. Impact of Endocrine Aging on Brain and Immune Responses
    Farida Sohrabji; Fiscal Year: 2010
    ..Collectively, these studies will test the hypothesis that in order for estrogen replacement to be beneficial, therapy must be initiated before compensatory responses to ovarian decline. ..
  31. Treating Adolescents with CSA-Related PTSD
    Edna B Foa; Fiscal Year: 2010
  32. Bipolar II Depression: Lithium, SSRI, or the Combination
    Trisha Suppes; Fiscal Year: 2010
    ..We also hypothesize that the frequency of side effects will be significantly less in patients on SSRI monotherapy. Thus, secondary aims include assessment of patient satisfaction, which may affect compliance in the clinical setting. ..
  33. Sex Chromosomes in Fetal Programming and Susceptibility to EAE
    Cory Teuscher; Fiscal Year: 2010
  34. Th2 effects on eicosanoid pathways: implications for altered innate responses in
    Sally E Wenzel; Fiscal Year: 2010
    ..These three aims should provide new insights into how relationships between innate and adaptive/allergic immune responses influence inflammatory/repair, and finally clinical outcomes in chronic and acute asthma. ..
  35. Cytoskeletal-Based Survival Pathways in Myocardium
    Richard Vander Heide; Fiscal Year: 2010
  36. Inflammation of Myofibroblasts and Loss of Elastic Recoil in Severe Asthma
    Sally E Wenzel; Fiscal Year: 2010
    ..Completing these aims should lead to an improved understanding of the contribution of inflammation and injury repair in the small airways/alveoli to the development of severe asthma. These findings may improve therapy as well. ..
  37. Impact on Reproductive Aging on Neural-Immune Responses
    Farida Sohrabji; Fiscal Year: 2009
    ..We will measure inflammatory mediators in peripheral organs (liver) and specific brain regions, leukocyte trafficking in the brain due to this systemic insult and neuronal cell death. ..
  38. Antidepressants During Office-based Buprenorphine
    Michael Stein; Fiscal Year: 2008
    ..The focus of this study, the evaluation of combinations of medications, to treat substance-related disorders, fits squarely within the emphasis of this RFA. [unreadable] [unreadable] [unreadable]..
  39. Vascular and Inflammatory Predictors of MCI Risk and Progression
    ROSEBUD ROBERTS; Fiscal Year: 2008
    ..The K01 award will culminate in an R01 application that will pave the way for the candidate to become an independent investigator in MCI and AD research. [unreadable] [unreadable] [unreadable]..
  40. Effects of Perinatal Depression on PTD and LBW
    Kimberly Yonkers; Fiscal Year: 2008
    ..Further, if we determine antidepressants increase the risk of adverse perinatal outcomes, treatment with psychotherapy rather than antidepressants should be considered when recommending therapeutic options. [unreadable] [unreadable]..
  41. Susceptibilty and Resistance Loci in Mouse EAE
    Cory Teuscher; Fiscal Year: 2008
  42. Collaterals in Aging: Enhanced by Genetic/Cell Therapy?
    Stephen Epstein; Fiscal Year: 2008
    ..If this novel strategy is validated, the results will be of immense value in developing individualized therapies for improving collateral flow clinically, a goal that has to date proven elusive. ..
  43. Psychosocial Res. to Improve Drug Treatment in Pregnancy
    Kimberly Yonkers; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  44. A Brief Marijuana Intervention for Adolescent Women
    Michael Stein; Fiscal Year: 2008
    ..If effective, this brief marijuana intervention can be readily integrated into existing women's primary care sites. ..
    Cory Teuscher; Fiscal Year: 2009
    ..abstract_text> ..
  46. Transforming PCI Informed Consent into an Evidence-based Decision-making Tool
    John A Spertus; Fiscal Year: 2010
    ..We will then estimate the cost-savings associated with more rational BAT use to test the hypothesis that PRISM will improve the cost-effectiveness of PCI. ..
  47. Serum Protemic Patterns Associated With Atherosclerosis
    Mark Pletcher; Fiscal Year: 2006
  48. Sepsis and Critical Illness in Babies > 34 Weeks Gestation
    GABRIEL ESCOBAR; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
    Michael Stein; Fiscal Year: 2002
    ..abstract_text> ..
    Kimberly Yonkers; Fiscal Year: 2003
    ..phenotypic indices of vulnerability using combinations of clinical and psychophysiological measures. ..
    Michael Stein; Fiscal Year: 2004
    ..Our results will have policy implications for needle exchange programs where many IDUs have initiated HIV risk reduction. ..
    Melissa Hudson; Fiscal Year: 2003
    ..abstract_text> ..
    Kimberly Yonkers; Fiscal Year: 2003
    ..abstract_text> ..
    Cory Teuscher; Fiscal Year: 2001
    ..D2Orch3CT3 recombinant congenic mice to narrow down the support interval encoding the locus to a size amenable to positional cloning (less than 1 cM), and 2) construct a yeast artificial chromosome (YAC) contig encompassing Orch3. ..
  55. Treating PMS/PMDD--Research versus Clinical Reality
    Kimberly Yonkers; Fiscal Year: 2003
    Michael Stein; Fiscal Year: 2003
    ..abstract_text> ..
  57. Genetic Polymorphisms Benign Prostatic Hyperplasia
    ROSEBUD ROBERTS; Fiscal Year: 2004
    ..This community-based cohort study should provide insights that should improve our understanding of the genetic control of hormonal mechanisms in the pathogenesis of BPH. ..
    Sally Wenzel; Fiscal Year: 2002
    ..abstract_text> ..
  59. Adapting to HIV Disease--A Family Intervention
    Michael Stein; Fiscal Year: 2004
    ..Given the significance of families in the AIDS epidemic, it is important to study as well as support families and patients to optimize care of those affected by HIV disease. ..
    Kenneth Lichstein; Fiscal Year: 2004
    ..abstract_text> ..
    Richard Vander Heide; Fiscal Year: 2001
    ..Experimental design will include morphologic, biochemical, and pharmacologic assessment of isolated myocytes subjected to myocardial ischemia. ..
    Edna Foa; Fiscal Year: 2005
    ..The resolution of these questions has important implications for understanding the pathophysiology of PTSD, and may provide insight into the mechanisms associated with successful psychological treatment for this disorder. ..
    Lisa Iezzoni; Fiscal Year: 2001
    ..abstract_text> ..
    Lisa Iezzoni; Fiscal Year: 2001
    ..Given that roughly 49 million Americans have a disabling condition, addressing concerns about their quality of care is essential. ..
    Michael Whyte; Fiscal Year: 2002
  66. Smoking Cessation Among Methadone Maintained Patients
    Michael Stein; Fiscal Year: 2005
    ..A3. To test the effects of the treatments on methadone treatment outcomes including methadone dose changes and continued use of illicit drugs, as measured by urine toxicologies. ..
    ROBERTO TREVINO; Fiscal Year: 2004
    ..Biological outcomes will fasting capillary glucose levels. Ultimately, we would like to delay or prevent the onset of type 2 diabetes. ..
  68. Mechanisms and Neural Consequences of Estrogen Action
    Farida Sohrabji; Fiscal Year: 2005
    ..Moreover, identifying hormone-stimulated pathways that initiate cell-degenerative events will be increasingly important to the development of target and receptor specific estrogenic compounds. ..
  69. How Access Affects Outcomes of Rehabilitation Services
    Lisa Iezzoni; Fiscal Year: 2005
    ..The primary outcome of the proposed study will be an assessment of the association of PT and OT, as routinely practiced nationwide and important outcomes of care. ..
    Edna Foa; Fiscal Year: 2001
    GABRIEL ESCOBAR; Fiscal Year: 2003
    ..abstract_text> ..
    RUSSELL POLAND; Fiscal Year: 2001
    ..The results of the proposed studies should provide basic information on potential links between the neurodevelopmental abnormalities and anomalies in adult neurochemistry defined by 1H MRS in schizophrenia. ..
  73. Promoting Healthy Aging through "Elder-Healer" Training
    William Collinge; Fiscal Year: 2004
    ..The goal is an educational program that is evidence-based, inspirational, and accessible to the growing mass market of elders seeking meaning and connection through service. ..
    Susan McMillan; Fiscal Year: 2002
    ..Quantitative data will be analyzed using repeated measures multivariate analysis of variance and structural equation modeling. ..
  75. A Randomized Trial in Liaison Psychiatry in Primary Care
    Wayne J Katon; Fiscal Year: 2010
    ..Secondary process and outcome measures will include functional disability, adherence to prescribed medications and disease self-management behaviors (i.e. physical activity and nutrition). ..
  76. Role of ASIC3 in the etiology of fibromyalgia
    Kathleen A Sluka; Fiscal Year: 2010
    ..These studies could lead to peripherally based therapeutic approaches to control pain without undesirable CMS (central nervous system) side effects, including gene therapy. ..
  77. Development of limited contact CBT treatment for IBS
    JEFFREY LACKNER; Fiscal Year: 2005
    ..abstract_text> ..
    Douglas Zatzick; Fiscal Year: 2002
    ..The award provide support for ongoing development as an investigator, clinical, and educator so that the applicant may ultimately become a productive clinical- scientist in an academic department of psychiatry. ..
    HENRY BALFOUR; Fiscal Year: 2008
    ..The Iowa subunit has expertise in detection of hepatitis C and will be collaborating in studies of the pathogenesis of coinfection with HIV and hepatitis C. ..
  80. HIV Related Stigma among Service Providers in China
    Li Li; Fiscal Year: 2005
    ..These data will prepare the team to conduct a randomized controlled trial across different levels of health care providers in China. ..
  81. Melatonin Randomized Trial in Insomnia in the Elderly
    Nalaka Gooneratne; Fiscal Year: 2006
    ..abstract_text> ..
  82. Prevention of Postpartum Weight Retention
    Rena Wing; Fiscal Year: 2009
  83. Physical Activity and Quality of Life in Multiple Sclerosis
    Robert Motl; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  84. Epidemiology of Bathing Disability in Elderly Persons
    Thomas Gill; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  85. Norepinephrine and Impulsivity
    Alan Swann; Fiscal Year: 2009
    ..The results of these experiments may suggest means for monitoring risk for impulsive behavior and for a rational treatment schema for impulsivity. ..
    Ronald Kessler; Fiscal Year: 2003
    Nalaka Gooneratne; Fiscal Year: 2004
    Lynn Sleeper; Fiscal Year: 2004
    ..abstract_text> ..
    Kurt Kroenke; Fiscal Year: 2004
    ..abstract_text> ..
    Noreen Clark; Fiscal Year: 2001
    John Piacentini; Fiscal Year: 2002
    ..The impact of baseline functioning, including family context, and initial change over time on treatment outcome will also be systematically evaluated. ..
    James Krause; Fiscal Year: 2002
    ..Risk profiles will be generated to identify individuals at greatest risk for early mortality. Separate analyses and risk profiles will be generated based on injury severity, gender and race/ethnicity. ..
  93. Screening for comorbidity in substance abuse clinics
    Carlos Blanco; Fiscal Year: 2004
    ..abstract_text> ..
    Paul Ridker; Fiscal Year: 2002
  95. Advancing the Treatment of Fecal & Urinary Incontinence
    William Whitehead; Fiscal Year: 2003
    ..The conference is scheduled to take place November 3-5, 2002, in Milwaukee, and half of the invitees have accepted invitations to speak. ..
    Andrew Gardner; Fiscal Year: 2004
    John Nutt; Fiscal Year: 2008
    ..unreadable] [unreadable]..