Genomes and Genes
Summary: A mechanism of communication within a system in that the input signal generates an output response which returns to influence the continued activity or productivity of that system.
Publications185 found, 100 shown here
- MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammalsJohn Tsang
Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Mol Cell 26:753-67. 2007..Our results strongly suggest that coordinated transcriptional and miRNA-mediated regulation is a recurrent motif to enhance the robustness of gene regulation in mammalian genomes...
- The coordination of movement: optimal feedback control and beyondJorn Diedrichsen
Institute of Cognitive Neuroscience, University College London, Alexandra House, 17 Queens Square, London, UK
Trends Cogn Sci 14:31-9. 2010Optimal control theory and its more recent extension, optimal feedback control theory, provide valuable insights into the flexible and task-dependent control of movements...
- Optimality principles in sensorimotor controlEmanuel Todorov
Department of Cognitive Science, University of California San Diego, La Jolla, California 92093 0515, USA
Nat Neurosci 7:907-15. 2004..Traditional emphasis has been on optimizing desired movement trajectories while ignoring sensory feedback. Recent work has redefined optimality in terms of feedback control laws, and focused on the mechanisms that ..
- Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolinE Carballo
Office of Clinical Research and Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Science 281:1001-5. 1998..These findings identify TTP as a component of a negative feedback loop that interferes with TNF-alpha production by destabilizing its messenger RNA...
- Competition between feedback loops underlies normal and pathological dynamics in the basal gangliaArthur Leblois
, Centre National de la Recherche Scientifique, , , 75270 Paris, France
J Neurosci 26:3567-83. 2006..the subthalamic nucleus, the internal pallidum (GPi), the thalamus, and the cortex are involved in closed feedback loops...
- Control of Dpp morphogen signalling by a secreted feedback regulatorRobin Vuilleumier
Institute for Biology I, Albert Ludwigs University of Freiburg, Hauptstrasse 1, D 79104 Freiburg, Germany
Nat Cell Biol 12:611-7. 2010..We show that Pent interacts with the glypican Dally to control Dpp distribution and provide evidence that proper establishment of the BMP morphogen gradient requires the inbuilt feedback loop embodied by Pent.
- Neural mechanisms underlying auditory feedback control of speechJason A Tourville
Department of Cognitive and Neural Systems, Boston University, 677 Beacon St, Boston, MA 02215, USA
Neuroimage 39:1429-43. 2008The neural substrates underlying auditory feedback control of speech were investigated using a combination of functional magnetic resonance imaging (fMRI) and computational modeling...
- Neural correlates of verbal feedback processing: an fMRI study employing overt speechIngrid K Christoffels
Department of Cognitive Neuroscience, Faculty of Psychology, Maastricht University, The Netherlands
Hum Brain Mapp 28:868-79. 2007Speakers use external auditory feedback to monitor their own speech. Feedback distortion has been found to increase activity in the superior temporal areas...
- MiR-34, SIRT1 and p53: the feedback loopMunekazu Yamakuchi
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Cell Cycle 8:712-5. 2009..Based on this observation, we propose a positive feedback loop, in which p53 induces expression of miR-34a which suppresses SIRT1, increasing p53 activity.
- ERP correlates of feedback and reward processing in the presence and absence of response choiceNick Yeung
Department of Psychology, Princeton University, Princeton, NJ 08544, USA
Cereb Cortex 15:535-44. 2005The feedback negativity is a component of the event-related brain potential that is elicited by feedback stimuli associated with unfavorable outcomes...
- Delay in feedback repression by cryptochrome 1 is required for circadian clock functionMaki Ukai-Tadenuma
Laboratory for Systems Biology, RIKEN Center for Developmental Biology, Chuo Ku, Kobe, Hyogo, Japan
Cell 144:268-81. 2011Direct evidence for the requirement of delay in feedback repression in the mammalian circadian clock has been elusive...
- The decision to enter mitosis: feedback and redundancy in the mitotic entry networkArne Lindqvist
Department of Medical Oncology, University Medical Center Utrecht, 3584 CG Utrecht, Netherlands
J Cell Biol 185:193-202. 2009..Within this network, several positive feedback loops can amplify cyclin B-Cdk1 activation to ensure complete commitment to a mitotic state once the decision to ..
- CPR quality improvement during in-hospital cardiac arrest using a real-time audiovisual feedback systemBenjamin S Abella
Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Resuscitation 73:54-61. 2007..We hypothesized that real-time feedback during CPR would improve the performance of chest compressions and ventilations during in-hospital cardiac arrest.
- Dependence of stem cell fate in Arabidopsis on a feedback loop regulated by CLV3 activityU Brand
Institut fur Entwicklungsbiologie, Universitat zu Koln, Gyrhofstrabetae 17, D 50923 Köln, Germany
Science 289:617-9. 2000..fate of stem cells in plant meristems is governed by directional signaling systems that are regulated by negative feedback. In Arabidopsis thaliana, the CLAVATA (CLV) genes encode the essential components of a negative, stem cell-..
- Neural correlates of auditory feedback control in humanA Toyomura
Research Institute of Science and Technology for Society, Japan Science and Technology Agency, Japan
Neuroscience 146:499-503. 2007Auditory feedback plays an important role in natural speech production...
- Positive feedback and noise activate the stringent response regulator rel in mycobacteriaKamakshi Sureka
Department of Chemistry, Bose Institute, Kolkata, India
PLoS ONE 3:e1771. 2008..two distinct peaks corresponding to low (L) and high (H) expression states, and further establish that a positive feedback loop involving the mprAB operon along with stochastic gene expression are responsible for the phenotypic ..
- An fMRI study of verbal self-monitoring: neural correlates of auditory verbal feedbackCynthia H Y Fu
Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
Cereb Cortex 16:969-77. 2006..According to the model, if the expected verbal feedback matches the perceived feedback, then there would be no change in activation in the lateral temporal cortices...
- Evidence for the flexible sensorimotor strategies predicted by optimal feedback controlDan Liu
Department of Cognitive Science, University of California, San Diego, La Jolla, California 92093 0515, USA
J Neurosci 27:9354-68. 2007..relationship between the task and the strategy most suitable for accomplishing it lies at the core of our optimal feedback control theory of coordination...
- Real-time contributions of auditory feedback to avian vocal motor controlJon T Sakata
Keck Center for Integrative Neuroscience, Department of Physiology, University of California, San Francisco, San Francisco, California 94143-0444, USA
J Neurosci 26:9619-28. 2006..Evidence strongly indicates that auditory feedback contributes in real time to human speech, but similar contributions of feedback to birdsong remain unclear...
- Thyroid hormone exerts negative feedback on hypothalamic type 4 melanocortin receptor expressionStéphanie Decherf
Departement Regulations, Centre National de la Recherche Scientifique Unité Mixte de Recherche 7221, Evolution des Regulations Endocriniennes, Museum national d histoire naturelle, Paris, France
Proc Natl Acad Sci U S A 107:4471-6. 2010..These facts led us to test the hypothesis that energy homeostasis should require negative feedback by T(3) on Mc4r expression...
- A systematic review of selected interventions for worksite health promotion. The assessment of health risks with feedbackRobin E Soler
National Center for Health Marketing, CDC, Atlanta, Georgia 30333, USA
Am J Prev Med 38:S237-62. 2010..report provides recommendations on the effectiveness of interventions that use an Assessment of Health Risks with Feedback (AHRF) when used alone or as part of a broader worksite health promotion program to improve the health of ..
- Computational motor control: feedback and accuracyEmmanuel Guigon
INSERM U742, ANIM, Université Pierre et Marie Curie UPMC Paris 6, 9, quai Saint Bernard, 75005 Paris, France
Eur J Neurosci 27:1003-16. 2008..in which motor variability results from the interplay between sensory and motor execution noises in an optimal feedback-controlled system...
- Cortical factor feedback model for cellular locomotion and cytofissionShin I Nishimura
Department of Computational Science and Engineering, Nagoya University, Nagoya, Japan
PLoS Comput Biol 5:e1000310. 2009..In this paper, we propose a hypothesis that the positive feedback mechanism working through the inhomogeneous distribution of regulatory proteins underlies this variety of cell ..
- Receiving a summary of the results of a trial: qualitative study of participants' viewsMary Dixon-Woods
Social Science Group, Department of Health Sciences, University of Leicester, Leicester LE1 6TP
BMJ 332:206-10. 2006..To explore trial participants' responses to receiving a summary of the results of a trial in pregnancy...
- Error and feedback processing in children with ADHD and children with Autistic Spectrum Disorder: an EEG event-related potential studyYvonne Groen
Department of Psychiatry, University Medical Center Groningen, University of Groningen, P O Box 660, 9700 AR Groningen, The Netherlands
Clin Neurophysiol 119:2476-93. 2008....
- Feedforward and feedback inhibition in neostriatal GABAergic spiny neuronsJames M Tepper
Center for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Avenue, Newark, NJ 07102, USA
Brain Res Rev 58:272-81. 2008..The feedback circuit comprises the numerous spiny projection neurons and their interconnections via local axon collaterals...
- Direct neural sensory feedback and control of a prosthetic armGurpreet Singh Dhillon
Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
IEEE Trans Neural Syst Rehabil Eng 13:468-72. 2005..We believe this to be the first demonstration of direct neural feedback from and direct neural control of an artificial arm in amputees.
- A sensory feedback circuit coordinates muscle activity in DrosophilaCynthia L Hughes
Molecular Neurobiology Laboratory, The Salk Institute, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
Mol Cell Neurosci 35:383-96. 2007..The bipolar dendrites and class I mds send a feedback signal to the CNS that keeps the contraction wave progressing quickly, allowing smooth forward movement...
- Interconnected feedback loops in the Neurospora circadian systemK Lee
Department of Genetics, Dartmouth Medical School, Hanover, NH 03755 3844, USA
Science 289:107-10. 2000..FRQ thus plays dual roles in the Neurospora clock and thereby, with WC-1, forms a second feedback loop that would promote robustness and stability in this circadian system...
- Stretch-induced changes in heart rate and rhythm: clinical observations, experiments and mathematical modelsP Kohl
University Laboratory of Physiology, Oxford, UK
Prog Biophys Mol Biol 71:91-138. 1999..direction of the cross-talk between cardiac electrical and mechanical activity is referred to as mechano-electric feedback (MEF)...
- Meta-analysis: audit and feedback features impact effectiveness on care qualitySylvia J Hysong
Houston VA HSR and D Center of Excellence, Health Services Research and Development Service, Department of Veterans Affairs Medical Center, TX, USA
Med Care 47:356-63. 2009Audit and feedback (A&F) has long been used to improve quality of care, albeit with variable results...
- Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brainAiwu Cheng
Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Dev Biol 258:319-33. 2003....
- Hes6 acts in a positive feedback loop with the neurogenins to promote neuronal differentiationN Koyano-Nakagawa
The Salk Institute for Biological Studies, PO Box 85800, La Jolla, CA 92186 5800, USA
Development 127:4203-16. 2000..The properties of Hes6 distinguish it from other members of the WRPW-bHLH family in vertebrates, and suggest that it acts in a positive-feedback loop with the proneural bHLH proteins to promote neuronal differentiation.
- Noise propagation and signaling sensitivity in biological networks: a role for positive feedbackGil Hornung
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
PLoS Comput Biol 4:e8. 2008..Negative feedback can buffer this type of noise, but this buffering comes at the expense of an even greater reduction in signaling ..
- Modular cell biology: retroactivity and insulationDomitilla Del Vecchio
Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48109, USA
Mol Syst Biol 4:161. 2008..To attenuate the effect of retroactivity, we propose a feedback mechanism inspired by the design of amplifiers in electronics...
- Compensatory responses to loudness-shifted voice feedback during production of Mandarin speechHanjun Liu
Department of Communication Sciences and Disorders, Northwestern University, 2240 Campus Drive, Evanston, Illinois 60208, USA
J Acoust Soc Am 122:2405-12. 2007Previous studies have demonstrated that perturbations in voice pitch or loudness feedback lead to compensatory changes in voice F(0) or amplitude during production of sustained vowels...
- A c-Myc-SIRT1 feedback loop regulates cell growth and transformationJian Yuan
Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA
J Cell Biol 185:203-11. 2009..Overall, our experiments identify a c-Myc-SIRT1 feedback loop in the regulation of c-Myc activity and cellular transformation, supporting/suggesting a role of SIRT1 in ..
- Vocalization-induced enhancement of the auditory cortex responsiveness during voice F0 feedback perturbationRoozbeh Behroozmand
Speech Physiology Laboratory, Department of Communication Science and Disorders, Northwestern University, 2240 Campus Drive, Evanston, IL 60208, USA
Clin Neurophysiol 120:1303-12. 2009The present study investigated whether self-vocalization enhances auditory neural responsiveness to voice pitch feedback perturbation and how this vocalization-induced neural modulation can be affected by the extent of the feedback ..
- Representation of internal models of action in the autistic brainCourtney C Haswell
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Nat Neurosci 12:970-2. 2009..autistic brain built a stronger than normal association between self-generated motor commands and proprioceptive feedback; furthermore, the greater the reliance on proprioception, the greater the child's impairments in social function ..
- Clinical teaching improves with resident evaluation and feedbackKeith Baker
Harvard Medical School, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Anesthesiology 113:693-703. 2010The literature is mixed on whether evaluation and feedback to clinical teachers improves clinical teaching...
- Feedback control of the protein kinase TAK1 by SAPK2a/p38alphaPeter C F Cheung
MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, Dow Street, University of Dundee, Dundee DD1 5EH, UK
EMBO J 22:5793-805. 2003..Our results suggest that TAB1 participates in a SAPK2a/p38alpha-mediated feedback control of TAK1, which not only limits the activation of SAPK2a/p38alpha but synchronizes its activity with other ..
- A randomized trial of computer-based reminders and audit and feedback to improve HIV screening in a primary care settingV Sundaram
VA Palo Alto Healthcare System, Palo Alto, CA, USA
Int J STD AIDS 20:527-33. 2009..The objective of the study was to determine whether an intervention with computer-based reminders and feedback would increase screening for HIV in a Department of Veterans Affairs (VA) health-care system...
- Enabling multi-level relevance feedback on PubMed by integrating rank learning into DBMSHwanjo Yu
CSE Department, POSTECH, Pohang, South Korea
BMC Bioinformatics 11:S6. 2010..This paper proposes a novel multi-level relevance feedback system for PubMed, called RefMed, which supports both ad-hoc keyword queries and a multi-level relevance feedback ..
- Development of intraoperative electrochemical detection: wireless instantaneous neurochemical concentration sensor for deep brain stimulation feedbackJamie J Van Gompel
Department of Neurological Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
Neurosurg Focus 29:E6. 2010..on a second-to-second time scale or for chronically used implanted recordings, as would be required for DBS feedback. Electrochemical detection techniques such as fast-scan cyclic voltammetry (FSCV) and amperometry have until ..
- PTH increases FGF23 gene expression and mediates the high-FGF23 levels of experimental kidney failure: a bone parathyroid feedback loopVardit Lavi-Moshayoff
Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew Univ Medical Center, PO Box 12000, Jerusalem, Israel 91120
Am J Physiol Renal Physiol 299:F882-9. 2010..The effect of PTH on FGF23 completes a bone-parathyroid endocrine feedback loop. Importantly, secondary hyperparathyroidism is essential for the high-FGF23 levels in early CKD.
- Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alphaI Novoa
Skirball Institute of Biomolecular Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
J Cell Biol 153:1011-22. 2001..These findings implicate GADD34-mediated dephosphorylation of eIF2alpha in a negative feedback loop that inhibits stress-induced gene expression, and that might promote recovery from translational inhibition ..
- HD-ZIP III activity is modulated by competitive inhibitors via a feedback loop in Arabidopsis shoot apical meristem developmentYoun Sung Kim
Department of Chemistry, Seoul National University, Seoul 151 742, Korea
Plant Cell 20:920-33. 2008..We therefore propose that HD-ZIP III activity in regulating SAM development is modulated by, among other things, a feedback loop involving the competitive inhibitors ZPR3 and ZPR4.
- Multiple parietal reach regions in humans: cortical representations for visual and proprioceptive feedback during on-line reachingFlavia Filimon
Department of Cognitive Science, University of California, San Diego, La Jolla, California 92093, USA
J Neurosci 29:2961-71. 2009Reaching toward a visual target involves at least two sources of information. One is the visual feedback from the hand as it approaches the target...
- Estimating the sources of motor errors for adaptation and generalizationMax Berniker
Rehabilitation Institute of Chicago, Department of Physical Medicine and Rehabilitation, Northwestern University, 345 E Superior Street, ONT 931, Chicago, Illinois 60611, USA
Nat Neurosci 11:1454-61. 2008..We provide evidence that many movement-generalization phenomena emerge from a strategy by which the nervous system estimates the sources of our motor errors...
- How much feedback is necessary for learning to suture?A O'Connor
Department of Mechanical Engineering, Tufts University, 200 College Avenue, Medford, Massachusetts 02155, USA
Surg Endosc 22:1614-9. 2008..In addition, the overall workload of a trainee during training would decrease as skills improved, especially when KR and coaching were provided...
- Feedback signals from cat's area 21a enhance orientation selectivity of area 17 neuronsC Wang
Discipline of Anatomy and Histology, School of Medical Sciences and Bosch Institute F13, The University of Sydney, Sydney, NSW 2006, Australia
Exp Brain Res 182:479-90. 2007We have studied the contribution of feedback signals originating from one of the "form-processing" extrastriate cortical areas, area 21a (A21a), to orientation selectivity of single neurons in the ipsilateral area 17 (A17)...
- Effects of visual force feedback on robot-assisted surgical task performanceCarol E Reiley
Engineering Research Center and Computer Integrated Surgery Systems and Technology, Johns Hopkins University, Baltimore, MD, USA
J Thorac Cardiovasc Surg 135:196-202. 2008Direct haptic (force or tactile) feedback is negligible in current surgical robotic systems. The relevance of haptic feedback in robot-assisted performances of surgical tasks is controversial...
- From single-cell genetic architecture to cell population dynamics: quantitatively decomposing the effects of different population heterogeneity sources for a genetic network with positive feedback architectureNikos V Mantzaris
Department of Chemical and Biomolecular Engineering, Rice University, Houston, Texas 77005, USA
Biophys J 92:4271-88. 2007..that can quantitatively isolate both heterogeneity sources and applied it to a genetic network with positive feedback architecture...
- Role of corticofugal feedback in hearingNobuo Suga
Department of Biology, Washington University, One Brookings Drive, St Louis, MO 63130, USA
J Comp Physiol A Neuroethol Sens Neural Behav Physiol 194:169-83. 2008..The corticofugal system forms multiple feedback loops...
- A randomized clinical trial of clinician feedback to improve quality of care for inner-city children with asthmaMeyer Kattan
Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
Pediatrics 117:e1095-103. 2006..Barriers impede translating recommendations for asthma treatment into practice, particularly in inner cities where asthma morbidity is highest...
- Internalizing agency of self-action: perception of one's own hand movements depends on an adaptable prediction about the sensory action outcomeMatthis Synofzik
Department of Cognitive Neurology, Hertie Institute of Clinical Brain Research, University of Tubingen, Tubingen, Germany
J Neurophysiol 96:1592-601. 2006..Twenty human subjects performed out-and-back pointing movements that were fed back visually. Feedback was initially presented in spatiotemporal correspondence with respect to the actual finger position, but later ..
- Adaptive control of saccades via internal feedbackHaiyin Chen-Harris
Departments of Biomedical Engineering and Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
J Neurosci 28:2804-13. 2008Ballistic movements like saccades require the brain to generate motor commands without the benefit of sensory feedback. Despite this, saccades are remarkably accurate...
- Neural correlates of developmental differences in risk estimation and feedback processingLinda van Leijenhorst
Center for Mind and Brain, University of California at Davis, USA
Neuropsychologia 44:2158-70. 2006..The task was designed to tap two important aspects of decision-making: risk estimation and feedback processing...
- Interactions between auditory and somatosensory feedback for voice F0 controlCharles R Larson
Department of Communication Sciences and Disorders, Northwestern University, 2240 Campus Drive, Evanston, IL 60208, USA
Exp Brain Res 187:613-21. 2008Previous studies have demonstrated the importance of both kinesthetic and auditory feedback for control of voice fundamental frequency (F0)...
- Human midbrain sensitivity to cognitive feedback and uncertainty during classification learningA R Aron
Dept. of Psychology and Brain Research Institute, University of California-Los Angeles, CA 90065, USA
J Neurophysiol 92:1144-52. 2004..classification learning in humans using functional magnetic resonance imaging to examine the effects of feedback and uncertainty...
- Amplification of dopaminergic signaling by a positive feedback loopA Nishi
Department of Physiology, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
Proc Natl Acad Sci U S A 97:12840-5. 2000..Together, these results indicate that via positive feedback mechanisms, Cdk5 signaling and PKA signaling are mutually antagonistic.
- Persistence of motor adaptation during constrained, multi-joint, arm movementsR A Scheidt
Department of Biomedical Engineering, Northwestern University, Evanston, IL 60622, USA
J Neurophysiol 84:853-62. 2000....
- Support vector machine-based classification scheme for myoelectric control applied to upper limbMohammadreza Asghari Oskoei
Department of Computing and Electronic Systems, University of Essex, Colchester CO4 3SQ, UK
IEEE Trans Biomed Eng 55:1956-65. 2008..The entropy of the output of the classifier is also examined as an online index to evaluate the correctness of classification; this can be used by online training for long-term myoelectric control operations...
- Synchronization of two coupled self-excited systems with multi-limit cyclesH G Enjieu Kadji
Laboratory of Modelling and Simulation in Engineering and Biological Physics, Faculty of Science, University of Yaounde I, Box 812, Yaounde, Cameroon
Chaos 17:033113. 2007..The stability boundaries and expressions of the synchronization time are obtained using the properties of the Hill equation. Numerical simulations validate and complement the results of analytical investigations...
- Global synchronization in lattices of coupled chaotic systemsJonq Juang
Department of Applied Mathematics, National Chiao Tung University, Hsinchu, Taiwan 300, Republic of China
Chaos 17:033111. 2007..Moreover, by merely checking the structure of the vector field of the single oscillator, we shall be able to determine if the system is globally synchronized...
- Spatiotemporal dynamics in a ring of N mutually coupled self-sustained systemsH G Enjieu Kadji
Laboratory of Modelling and Simulation in Engineering and Biological Physics, Faculty of Science, University of Yaounde I, Box 812, Yaounde, Cameroon
Chaos 17:033109. 2007..Numerical simulations validate and complement the results of analytical investigations. The influences of coupling parameter mismatch on the forecasted stability boundaries are also highlighted...
- Operating regimes of signaling cycles: statics, dynamics, and noise filteringCarlos Gomez Uribe
Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
PLoS Comput Biol 3:e246. 2007..Numerical simulations show that our analytical results hold well even for noise of large amplitude. We suggest that noise filtering and tunability make signaling cycles versatile components of more elaborate cell-signaling pathways...
- Estimation of hidden state variables of the Intracranial system using constrained nonlinear Kalman filtersXiao Hu
Brain Monitoring and Modeling Laboratory, Division of Neurosurgery, University of California, Los Angeles, CA 90034, USA
IEEE Trans Biomed Eng 54:597-610. 2007..Finally, the state estimator combined with the I/O configuration that has both ICP and CBFV as outputs can potentially estimate the lumped cerebral arterial radii, which are not measurable in a typical clinical environment...
- Periodicity and chaos in electrically coupled Hindmarsh-Rose neuronsR Erichsen
Instituto de Fisica, Universidade Federal do Rio Grande do Sul, Caixa Postal 15051, 91501 970 Porto Alegre, RS, Brazil
Phys Rev E Stat Nonlin Soft Matter Phys 74:061906. 2006..At the strong coupling regime in-phase chaotic evolution dominates, but windows with complex periodic behavior are also present...
- Simulating closed- and open-loop voluntary movement: a nonlinear control-systems approachPaul R Davidson
Department of Electrical and Electronic Engineering, University of Canterbury, Christchurch, New Zealand
IEEE Trans Biomed Eng 49:1242-52. 2002In many recent human motor control models, including feedback-error learning and adaptive model theory (AMT), feedback control is used to correct errors while an inverse model is simultaneously tuned to provide accurate feedforward ..
- The frequency of human, manual adjustments in balancing an inverted pendulum is constrained by intrinsic physiological factorsIan D Loram
Institute for Biophysical and Clinical Research into Human Movement, Manchester Metropolitan University, Alsager ST7 2HL, UK
J Physiol 577:417-32. 2006..The spring bias was controlled by a sensitive joystick via a servo motor and accurate visual feedback was provided on an oscilloscope...
- Manually controlled human balancing using visual, vestibular and proprioceptive senses involves a common, low frequency neural processMartin Lakie
Applied Physiology Research Group, School of Sport and Exercise Sciences, University of Birmingham, UK
J Physiol 577:403-16. 2006..We predict that similar processes may be identified in the control of standing...
- Coexisting chaotic and periodic dynamics in clock escapementsFrancis C Moon
Joseph Ford Professor of Mechanical Engineering, Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, New York, NY 14853 7501, USA
Philos Trans A Math Phys Eng Sci 364:2539-63. 2006..This model is shown to exhibit a strange attractor in the structural vibration of the clock. The internal feedback between the oscillator and the escapement structure is similar to anti-control of chaos models.
- Experimental evidence of anomalous phase synchronization in two diffusively coupled Chua oscillatorsSyamal Kumar Dana
Instrument Division, Indian Institute of Chemical Biology, Jadavpur, Kolkata 700032, India
Chaos 16:023111. 2006..All experimental results are supported by numerical simulations of two coupled Chua models...
- Fractional dynamics of coupled oscillators with long-range interactionVasily E Tarasov
Skobeltsyn Institute of Nuclear Physics, Moscow State University, Moscow 119992, Russia
Chaos 16:023110. 2006..Particular solutions for fractional time-dependent complex Ginzburg-Landau (or nonlinear Schrodinger) equation are derived. These solutions are interpreted as synchronized states and localized structures of the oscillatory medium...
- Chaotic synchronization through coupling strategiesShuguang Guan
Temasek Laboratories, National University of Singapore, 5 Sports Drive 2, 117508 Singapore and Beijing-Hong Kong-Singapore Joint Center of Nonlinear and Complex Systems (Singapore, National University of Singapore, 117543 Singapore
Chaos 16:023107. 2006..Moreover, experimental verification based on electronic circuits has been carried out to support the numerical results. Our work provides a method to obtain robust CS in synchronization-based chaos communications...
- A new method to realize cluster synchronization in connected chaotic networksZhongjun Ma
College of Sciences, Shanghai University, Shanghai, 200444, China
Chaos 16:023103. 2006..The effectiveness of the method is illustrated by an example...
- Chaos quasisynchronization induced by impulses with parameter mismatchesChuandong Li
Department of Computer Science, Chongqing University, 400044, People's Republic of China
Chaos 16:023102. 2006..Numerical simulations on the chaotic Chua's circuit are presented to verify the theoretical results...
- Motor adaptation to single force pulses: sensitive to direction but insensitive to within-movement pulse placement and magnitudeMichael S Fine
Department of Biomedical Engineering, Washington University, 1 Brookings Dr, Campus Box 1097, Saint Louis, Missouri 63130, USA
J Neurophysiol 96:710-20. 2006..used transient pulses of force, distributed pseudo-randomly throughout a movement set, to study how the timing of feedback within a movement influenced subsequent predictive control...
- Introduction: dissipative localized structures in extended systemsMustapha Tlidi
Universite Libre de Bruxelles, Optique Nonlinéaire Théorique, CP 231 Campus Plaine, Bruxelles 1050, Belgium
Chaos 17:037101. 2007..In particular, localized structures could be used as "bits" for parallel information storage and processing...
- Nonvariational real Swift-Hohenberg equation for biological, chemical, and optical systemsG Kozyreff
Optique Nonlinéaire Théorique, Universite Libre De Bruxelles U L B, Campus de la Plaine C P 231, Boulevard du Triomphe, B 1050 Bruxelles, Belgium
Chaos 17:037103. 2007..Finally, we derive the equation on a general class of partial differential systems...
- A cascade control approach for a class of biomedical systemsMoisés Ortiz-Vargas
Escuela de Ingeniería, Univ of Panamericana, Mexico DF
Conf Proc IEEE Eng Med Biol Soc 1:4420-3. 2006An approach for the robust feedback control of a class of biomedical systems in chained form is presented. The control approach is based on modeling error compensation techniques and a recursive cascade scheme...
- Comment on "Exponential stabilization of chaotic systems with delay by periodically intermittent control" [Chaos 17, 013103 (2007)]Shaojiang Deng
College of Computer Science, Chongqing University, 400030, China
Chaos 18:018101. 2008..In the referenced paper, there is a technical carelessness in the second lemma, and it is highlighted here to avoid possible failure when the result is used to design the intermittent controller for nonlinear systems...
- Multimode dynamics in a network with resource mediated couplingD E Postnov
Physics Department, Saratov State University, Astrakhanskaya str 83, Saratov, 410026, Russia
Chaos 18:015114. 2008..At higher coupling strengths, one typically observes spatial clustering involving a few oscillating units. We describe three different scenarios according to which the cluster can slide along the chain as the bias voltage changes...
- Stochastic phase dynamics and noise-induced mixed-mode oscillations in coupled oscillatorsNa Yu
Departments of Mathematic, University of British Columbia, Vancouver, British Columbia, V6T 1Z2 Canada
Chaos 18:015112. 2008..The phase difference between the coupled oscillators in the localized solution, coexisting with in-phase or antiphase solutions, is clearly represented in the stochastic phase dynamics...
- Noise-induced mixed-mode oscillations in a relaxation oscillator near the onset of a limit cycleCyrill B Muratov
Department of Mathematical Sciences, New Jersey Institute of Technology, Newark, New Jersey 07102, USA
Chaos 18:015111. 2008..These scenarios are corroborated by numerical simulations...
- Nonlocal branches of cycles, bistability, and topologically persistent mixed mode oscillationsE Bouse
Department of Applied Mathematics, University College Cork, Cork, Ireland
Chaos 18:015109. 2008..This natural scenario should be supplemented by simple and constructive criteria of existence, and methods of localization, of such S-shaped structures. These criteria are the main focus of the paper...
- Mixed-mode oscillations and slow manifolds in the self-coupled FitzHugh-Nagumo systemMathieu Desroches
Bristol Centre for Applied Nonlinear Mathematics, Department of Engineering Mathematics, University of Bristol, Queen s Building, Bristol BS8 1TR, United Kingdom
Chaos 18:015107. 2008..In particular, our techniques allow us to find and visualize canard solutions as the intersection curves of the attracting and repelling slow manifolds...
- Introduction to focus issue: mixed mode oscillations: experiment, computation, and analysisMorten Brons
Department of Mathematics, Technical University of Denmark, DK 2800 Kongens Lyngby, Denmark
Chaos 18:015101. 2008..This focus issue presents a series of articles on theoretical, numerical, and experimental aspects of MMOs. The applications cover physical, chemical, and biological systems...
- Recurrence analysis of strange nonchaotic dynamics in driven excitable systemsE J Ngamga
Nonlinear Dynamics Group, Institute of Physics, University of Potsdam, Potsdam 14415, Germany
Chaos 18:013128. 2008..In particular, we show the performance of the recurrence measures in detecting transitions to SNAs in quasiperiodically forced excitable systems and experimental time series...
- Synchronizability of network ensembles with prescribed statistical propertiesShuguang Guan
Temasek Laboratories, National University of Singapore, 117508 Singapore
Chaos 18:013120. 2008..Our work reveals that the synchronizability of a network can be significantly affected by the local pattern of connections, and the homogeneity of degree can greatly enhance network synchronizability for networks of a random nature...
- Time shifts and correlations in synchronized chaosJonathan N Blakely
U S Army Research, Engineering, and Development Command, AMSRD AMR WS ST, Redstone Arsenal, Alabama 35898, USA
Chaos 18:013117. 2008..Finally, we show that the transfer function can be exploited to design novel coupling schemes that significantly improve the correlation and increase the maximum achievable time shift...
- Quantifying the synchronizability of externally driven oscillatorsAndrzej Stefański
Division of Dynamics, Technical University of Lodz, Stefanowskiego 1 15, 90 924 Lodz, Poland
Chaos 18:013106. 2008..Finally, the idea of effective response Lyapunov exponents, which allows us to quantify the synchronizability in case of slightly different response oscillators, is introduced...
- Optimization of synchronization in complex clustered networksLiang Huang
Department of Electrical Engineering, Arizona State University, Tempe, Arizona 85287, USA
Chaos 18:013101. 2008..This phenomenon provides possible principles for optimal synchronization on complex clustered networks. We provide extensive numerical evidence and an analytic theory to establish the generality of this phenomenon...
- Sensitivity derivatives for flexible sensorimotor learningM N Abdelghani
Department of Physiology, University of Toronto, Toronto, Ontario, Canada
Neural Comput 20:2085-111. 2008..The mechanism, which we call implicit supervision, helps explain the flexibility and speed of sensorimotor learning and our ability to cope with high-dimensional work spaces and tools...
- Optimality, stochasticity, and variability in motor behaviorEmmanuel Guigon
INSERM U742, ANIM, Université Pierre et Marie Curie UPMC Paris 6, 9, quai Saint Bernard, 75005, Paris, France
J Comput Neurosci 24:57-68. 2008....
- Point-based rigid-body registration using an unscented Kalman filterMehdi Hedjazi Moghari
Department of Electrical and Computer Engineering, Queen s University, Kingston ON K7L 3N6, Canada
IEEE Trans Med Imaging 26:1708-28. 2007..It is also shown that the proposed registration algorithm is more robust than the ICP registration algorithm in terms of outliers in data sets and initial misalignment between the two data sets...
- A biologically inspired modular structure to control the sit-to-stand transfer of a biped robotM Emadi Andani
School of Electrical and Computer Engineering ECE, University of Tehran, Iran
Conf Proc IEEE Eng Med Biol Soc 2007:3016-9. 2007..Our results showed that only two modules out of four were selected to control the STS task. Responsibility of controlling the task was switched between the two modules around the seat-off moment...
- Nonlinear analysis of cerebral hemodynamic and intracranial pressure signals for characterization of autoregulationXiao Hu
Brain Monitoring and Modeling Laboratory, Division of Neurosurgery, University of California, Los Angeles 90034, USA
IEEE Trans Biomed Eng 53:195-209. 2006..On the other hand, complex patterns of C measure evolution were observed among 14 cases of propofol data indicating a nontrivial effect of propofol on the dependency of CBFV on ABP...
- Discretization of frequencies in delay coupled oscillatorsSerhiy Yanchuk
Weierstrass Institute for Applied Analysis and Stochastics, Mohrenstrasse 39, D 10117 Berlin, Germany
Phys Rev E Stat Nonlin Soft Matter Phys 72:036205. 2005..Due to the delay, the allowed frequencies of the oscillators are shown to be discretized. The phenomenon is observed in the case when the delay is much larger than the characteristic period of the solitary uncoupled oscillator...
- Application of cross time-frequency analysis to postural sway behavior: the effects of aging and visual systemsYong June Shin
Department of Electrical Engineering, The University of South Carolina, Columbia, SC 29208, USA
IEEE Trans Biomed Eng 52:859-68. 2005In this paper, the effects of visual feedback and aging on postural sway systems and signals are investigated by analyzing the transient phase difference between "input" and "output" which correspond to center of ..
Research Grants137 found, 100 shown here
- ENSEMBLE MODEL OF STRESS ACTH-ADRENAL AXISJohannes Veldhuis; Fiscal Year: 2005..sheep, horse and human, the stress-responsive corticotropic-adrenal axis can be viewed as a dynamically adaptive feedback system supervised by key brain (hypothalamic) regulatory centers...
- Ensemble Control of ACTH Secretion: Impact of GenderJohannes Veldhuis; Fiscal Year: 2007..receptor (ER and AR); (2) graded " imposition of delayed (integral) and rapid (rate-sensitive) cortisol negative feedback during adrenal steroidogenic blockade; (3) joint dose-dependent stimulation of ACTH secretion by human CRH and ..
- Age-Dependent Estrogen-Independent Mechanism of Hyposomatotropism in WomenJohannes Veldhuis; Fiscal Year: 2007..Hypothesis III: Age and E2 availability jointly modulate concentration-dependent negative feedback by free (protein-unbound) IGF-I, thus controlling mean daily GH secretion...
- ACTIONS OF ESTROGEN IN MATURING GRAAFIAN FOLLICLESJohannes Veldhuis; Fiscal Year: 2001....
- Ensemble Control of ACTH Secretion: Impact of GenderJohannes Veldhuis; Fiscal Year: 2009..receptor (ER and AR); (2) graded " imposition of delayed (integral) and rapid (rate-sensitive) cortisol negative feedback during adrenal steroidogenic blockade; (3) joint dose-dependent stimulation of ACTH secretion by human CRH and ..
- Ensemble Disruption of the GnRH-LH-Testosterone AxisJohannes Veldhuis; Fiscal Year: 2007..Interpreted from this vantage, published literature, laboratory experiments, background data and ensemble feedback/feed forward simulations predict that hydroandrogenemia in aging men could arise nonexclusively by way of: (i) ..
- THE AGING GH AXIS IN POSTMENOPAUSAL WOMENJohannes Veldhuis; Fiscal Year: 2005..Hypothesis III: Estrogen add back can override GH's autonegative feedback restraint of GH secretion...
- ACTIONS OF ESTROGEN IN MATURING GRAAFIAN FOLLICLESJohannes Veldhuis; Fiscal Year: 2005..Understanding such fundamental interactions is important to the rational design of alternative strategies to interrupt normal and rescue impaired steroidogenesis in the maturing Graafian follicle and corpus luteum. ..
- ACTIONS OF TESTOSTERONE ON THE AGING MALE GH AXISJohannes Veldhuis; Fiscal Year: 2007..suppress GH secretory-burst mass in part by: (i) elevating somatostatin (SS) outflow under high (nighttime) GH feedback; and (ii) augmenting SSergic restraint under low (daytime) GH feedback...
- Analytical Reconstruction of Feedback Signaling in Aging MenJohannes Veldhuis; Fiscal Year: 2007Self-adaptive (homeostatic) biological systems operate via repeated incremental feedback and feed forward signaling adjustments to maintain species, gender and age-defined physiological norms...
- Novel Active Repressor Model of Human LDL-Receptor RegulationJohannes Veldhuis; Fiscal Year: 2007..If so, targeting this gene product could potentially shift cholesterol accumulation away from arteries toward the liver. This would represent a new treatment approach for patients with atherosclerotic disease. ..
- Mechanistic bases for age-related androgen deficiencyJohannes Veldhuis; Fiscal Year: 2007..HYPOTHESIS III: Reduced negative feedback by testosterone, which unleashes high-frequency, low- amplitude and irregular LH release...
- Age-Dependent Estrogen-Independent Mechanism of Hyposomatotropism in WomenJohannes Veldhuis; Fiscal Year: 2009..Hypothesis III: Age and E2 availability jointly modulate concentration-dependent negative feedback by free (protein-unbound) IGF-I, thus controlling mean daily GH secretion...
- Aging Systems in Geriatrics: the Male Gonadal AxisJohannes D Veldhuis; Fiscal Year: 2010..pituitary luteinizing hormone (LH) secretion;(ii) impaired Leydig-cell responsiveness to LH pulses;and reduced feedback by Te onto GnRH and LH secretion...
- Age-Dependent Estrogen-Independent Mechanism of Hyposomatotropism in WomenJohannes D Veldhuis; Fiscal Year: 2010..Hypothesis III: Age and E2 availability jointly modulate concentration-dependent negative feedback by free (protein-unbound) IGF-I, thus controlling mean daily GH secretion...
- ACTIONS OF ESTROGEN IN MATURING GRAAFIAN FOLLICLESJohannes Veldhuis; Fiscal Year: 1993..The preceding studies should contribute important new insights into and further developments in fertility regulation in man, domestic animals, and endangered wild species...
- AGING GH AXIS IN POSTMENOPAUSAL WOMENJohannes Veldhuis; Fiscal Year: 2000..3. Estrogen replacement in postmenopausal women curtails inhibitory auto- feedback of the hypothalamo-pituitary GH unit otherwise exerted by IGF-I and/or GH...
- Ensemble Control of ACTH Secretion: Impact of GenderJohannes D Veldhuis; Fiscal Year: 2010..receptor (ER and AR);(2) graded " imposition of delayed (integral) and rapid (rate-sensitive) cortisol negative feedback during adrenal steroidogenic blockade;(3) joint dose-dependent stimulation of ACTH secretion by human CRH and AVP;..
- ACTIONS OF ESTROGEN IN MATURING GRAAFIAN FOLLICLESJohannes Veldhuis; Fiscal Year: 1990..Accordingly, these investigations are likely to contribute to new approaches to fertility regulation in the human, domestic animal or endangered wild species...
- Tests of neurobiologically-inspired Model of the Motivation-Learning InterfaceW TODD TODD MADDOX; Fiscal Year: 2010..This proposal reunites research on motivation and cognition to better understanding their effects on functioning in clinical populations. ..
- Effectiveness Trial of Attention Shaping for SchizophreniaSteven M Silverstein; Fiscal Year: 2010....
- Stochastic Models of Cell Cycle Regulation in EukaryotesJohn J Tyson; Fiscal Year: 2010..Hence, a validated stochastic model of the eukaryotic cell cycle is essential to progress in the field of molecular systems biology. ..
- 3/5-Cognitive Neuroscience Task Reliability & Clinical Applications ConsortiumSteven Silverstein; Fiscal Year: 2009..Thus, we need to improve our methods for detecting and enhancing cognitive function in schizophrenia in order to help individuals with this illness lead more productive and fulfilling lives. ..
- The Process of Group Therapy for Cocaine DependencePaul Crits Christoph; Fiscal Year: 2007..degree of patient participation, quality of participation, quality of the therapeutic alliance, and frequency of feedback (and positive feedback), as assessed in group drug counseling sessions, as predictors of treatment outcome...
- Stochastic Models of Cell Cycle Regulation in EukaryotesJohn Tyson; Fiscal Year: 2007..g., embyronic development, tissue regeneration, wound healing, and carcinogenesis. ..
- Effectiveness Trial of Attention Shaping for SchizophreniaSteven Silverstein; Fiscal Year: 2009....
- Psychotherapy for Major Depression in the CommunityPaul Crits Christoph; Fiscal Year: 2007..created will work synergistically with existing programs at Penn that focuses on psychotherapy research (Center for the Study of Psychotherapy) and mental health services research (Center for Mental Health Policy and Services Research) ..
- 3/5-Cognitive Neuroscience Task Reliability & Clinical Applications ConsortiumSteven M Silverstein; Fiscal Year: 2010..Thus, we need to improve our methods for detecting and enhancing cognitive function in schizophrenia in order to help individuals with this illness lead more productive and fulfilling lives. ..
- Video-Based Delivery of HIV Test Information for Spanish-Speaking LatinosRoland C Merchant; Fiscal Year: 2010..The ultimate aim of this project is to help reduce the transmission of HIV through streamlined yet effective HIV testing approaches. ..
- Motion Sensor Array for Vestibular-deficient IndividualsConrad Wall; Fiscal Year: 2005....
- Problem Solving Environment for Modeling the Cell CycleJohn Tyson; Fiscal Year: 2002..and some outstanding collaborators (Sible and Cross, experimental cell cycle research; Kitano and Bolouri, software development for molecular cell biology; and Kohn, bioinformatics of mammalian cell cycle controls). ..
- Volunteer Activities on Long-Term Care ResidentsHon Yuen; Fiscal Year: 2002..It is expected that findings will support the activity theory of aging and validate the beneficial effects of residents in LTC facilities participating in structured volunteer activities. ..
- ORAL HEALTH IN AFRICAN AMERICAN ADOLESCENTS WITH DIABETESHon Yuen; Fiscal Year: 2002..subproject abstract not provided ..
- Brief Intervention for Drug Misuse for the Emergency Department (BIDMED)Ted D Nirenberg; Fiscal Year: 2010..SBIRT in the ED for drug misuse has the potential for reaching people during a "teachable moment" during an ED visit that might be related to drug misuse. ..
- PITUITARY CELLS TO STUDY MALE INFERTILITYSTEPHEN WINTERS; Fiscal Year: 2002..abstract_text> ..
- Oral Health in People with Systemic SclerosisHon Yuen; Fiscal Year: 2007....
- Brief Intervention for Drug Misuse for the Emergency Department (BIDMED)Roland Merchant; Fiscal Year: 2009..SBIRT in the ED for drug misuse has the potential for reaching people during a "teachable moment" during an ED visit that might be related to drug misuse. ..
- Proprioceptive feedback gain modulation during movementMark Shapiro; Fiscal Year: 2007..The two main mechanisms by which movement is produced are predictive feedforward control and sensory feedback control. The interplay of these two mechanisms in single-joint goal-oriented movements will be studied...