feedback

Summary

Summary: A mechanism of communication within a system in that the input signal generates an output response which returns to influence the continued activity or productivity of that system.

Top Publications

  1. pmc MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals
    John Tsang
    Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Cell 26:753-67. 2007
  2. pmc Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha
    I Novoa
    Skirball Institute of Biomolecular Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Cell Biol 153:1011-22. 2001
  3. ncbi The p53 pathway: positive and negative feedback loops
    Sandra L Harris
    The Cancer Institute of New Jersey and the Institute for Advanced Study, New Jersey, NJ, USA
    Oncogene 24:2899-908. 2005
  4. ncbi A chemokine-driven positive feedback loop organizes lymphoid follicles
    K M Ansel
    Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
    Nature 406:309-14. 2000
  5. ncbi Optimal feedback control as a theory of motor coordination
    Emanuel Todorov
    Department of Cognitive Science, University of California, San Diego, 9500 Gilman Dr, La Jolla, California 92093 0515, USA
    Nat Neurosci 5:1226-35. 2002
  6. pmc The decision to enter mitosis: feedback and redundancy in the mitotic entry network
    Arne Lindqvist
    Department of Medical Oncology, University Medical Center Utrecht, 3584 CG Utrecht, Netherlands
    J Cell Biol 185:193-202. 2009
  7. ncbi Computational principles of movement neuroscience
    D M Wolpert
    Sobell Department of Neurophysiology, Institute of Neurology, University College London, UK
    Nat Neurosci 3:1212-7. 2000
  8. pmc Optimality principles in sensorimotor control
    Emanuel Todorov
    Department of Cognitive Science, University of California San Diego, La Jolla, California 92093 0515, USA
    Nat Neurosci 7:907-15. 2004
  9. ncbi Bayesian integration in sensorimotor learning
    Konrad P Kording
    Sobell Department of Motor Neuroscience, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Nature 427:244-7. 2004
  10. ncbi Delay in feedback repression by cryptochrome 1 is required for circadian clock function
    Maki Ukai-Tadenuma
    Laboratory for Systems Biology, RIKEN Center for Developmental Biology, Chuo Ku, Kobe, Hyogo, Japan
    Cell 144:268-81. 2011

Research Grants

  1. Adjuvant Treatment Decision Making for Lung Cancer
    Jamie Studts; Fiscal Year: 2006
  2. Ensemble Disruption of the GnRH-LH-Testosterone Axis
    Johannes Veldhuis; Fiscal Year: 2007
  3. Mechanistic bases for age-related androgen deficiency
    Johannes Veldhuis; Fiscal Year: 2007
  4. THE AGING GH AXIS IN POSTMENOPAUSAL WOMEN
    Johannes Veldhuis; Fiscal Year: 2005
  5. ENSEMBLE MODEL OF STRESS ACTH-ADRENAL AXIS
    Johannes Veldhuis; Fiscal Year: 2005
  6. Analytical Reconstruction of Feedback Signaling in Aging Men
    Johannes Veldhuis; Fiscal Year: 2008
  7. An Internet-based intervention for problem drinking
    John Cunningham; Fiscal Year: 2008
  8. Motion Sensor Array for Vestibular-deficient Individuals
    Conrad Wall; Fiscal Year: 2005
  9. Patient Feedback Effectiveness Study
    Paul Crits Christoph; Fiscal Year: 2008
  10. Combined Treatment for GAD
    Paul Crits Christoph; Fiscal Year: 2008

Detail Information

Publications262 found, 100 shown here

  1. pmc MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals
    John Tsang
    Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Cell 26:753-67. 2007
    ..Our results strongly suggest that coordinated transcriptional and miRNA-mediated regulation is a recurrent motif to enhance the robustness of gene regulation in mammalian genomes...
  2. pmc Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha
    I Novoa
    Skirball Institute of Biomolecular Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Cell Biol 153:1011-22. 2001
    ..These findings implicate GADD34-mediated dephosphorylation of eIF2alpha in a negative feedback loop that inhibits stress-induced gene expression, and that might promote recovery from translational inhibition ..
  3. ncbi The p53 pathway: positive and negative feedback loops
    Sandra L Harris
    The Cancer Institute of New Jersey and the Institute for Advanced Study, New Jersey, NJ, USA
    Oncogene 24:2899-908. 2005
    ..number of other signal transduction pathways in the cell and a number of positive and negative autoregulatory feedback loops act upon the p53 response...
  4. ncbi A chemokine-driven positive feedback loop organizes lymphoid follicles
    K M Ansel
    Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
    Nature 406:309-14. 2000
    ..a cytokine that promotes follicular dendritic cell development and BLC expression, establishing a positive feedback loop that is likely to be important in follicle development and homeostasis...
  5. ncbi Optimal feedback control as a theory of motor coordination
    Emanuel Todorov
    Department of Cognitive Science, University of California, San Diego, 9500 Gilman Dr, La Jolla, California 92093 0515, USA
    Nat Neurosci 5:1226-35. 2002
    ..Here we propose an alternative theory based on stochastic optimal feedback control...
  6. pmc The decision to enter mitosis: feedback and redundancy in the mitotic entry network
    Arne Lindqvist
    Department of Medical Oncology, University Medical Center Utrecht, 3584 CG Utrecht, Netherlands
    J Cell Biol 185:193-202. 2009
    ..Within this network, several positive feedback loops can amplify cyclin B-Cdk1 activation to ensure complete commitment to a mitotic state once the decision to ..
  7. ncbi Computational principles of movement neuroscience
    D M Wolpert
    Sobell Department of Neurophysiology, Institute of Neurology, University College London, UK
    Nat Neurosci 3:1212-7. 2000
    ..Our goal is to demonstrate how specific models emerging from the computational approach provide a theoretical framework for movement neuroscience...
  8. pmc Optimality principles in sensorimotor control
    Emanuel Todorov
    Department of Cognitive Science, University of California San Diego, La Jolla, California 92093 0515, USA
    Nat Neurosci 7:907-15. 2004
    ..Traditional emphasis has been on optimizing desired movement trajectories while ignoring sensory feedback. Recent work has redefined optimality in terms of feedback control laws, and focused on the mechanisms that ..
  9. ncbi Bayesian integration in sensorimotor learning
    Konrad P Kording
    Sobell Department of Motor Neuroscience, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Nature 427:244-7. 2004
    ..results from combining information about the distribution of velocities-the prior-with evidence from sensory feedback. As uncertainty increases, when playing in fog or at dusk, the system should increasingly rely on prior knowledge...
  10. ncbi Delay in feedback repression by cryptochrome 1 is required for circadian clock function
    Maki Ukai-Tadenuma
    Laboratory for Systems Biology, RIKEN Center for Developmental Biology, Chuo Ku, Kobe, Hyogo, Japan
    Cell 144:268-81. 2011
    Direct evidence for the requirement of delay in feedback repression in the mammalian circadian clock has been elusive...
  11. pmc Preventing smoking relapse via Web-based computer-tailored feedback: a randomized controlled trial
    Iman Elfeddali
    Department of Health Promotion, School for Public Health and Primary Care CAPHRI, Maastricht University, Maastricht, Netherlands
    J Med Internet Res 14:e109. 2012
    ..The Stay Quit for You (SQ4U) study compared two Web-based computer-tailored smoking relapse prevention programs with different types of planning strategies versus a control group...
  12. ncbi ERP correlates of feedback and reward processing in the presence and absence of response choice
    Nick Yeung
    Department of Psychology, Princeton University, Princeton, NJ 08544, USA
    Cereb Cortex 15:535-44. 2005
    The feedback negativity is a component of the event-related brain potential that is elicited by feedback stimuli associated with unfavorable outcomes...
  13. ncbi Engineering stability in gene networks by autoregulation
    A Becskei
    EMBL, Structures and Biocomputing, Heidelberg, Germany
    Nature 405:590-3. 2000
    ..It has been proposed, but not demonstrated, that autoregulatory, negative feedback loops in gene circuits provide stability, thereby limiting the range over which the concentrations of network ..
  14. ncbi Using theory to synthesise evidence from behaviour change interventions: the example of audit and feedback
    Benjamin Gardner
    Centre for Outcomes Research and Effectiveness, University College London, 1 19 Torrington Place, London WC1E 7HB, UK
    Soc Sci Med 70:1618-25. 2010
    ..We illustrate this method with an analysis of 'audit and feedback' interventions, based on data from a Cochrane review...
  15. pmc Feedback control of regulatory T cell homeostasis by dendritic cells in vivo
    Guillaume Darrasse-Jèze
    Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 206:1853-62. 2009
    ..We demonstrate the existence of a feedback regulatory loop between DCs and T reg cells...
  16. ncbi Dependence of stem cell fate in Arabidopsis on a feedback loop regulated by CLV3 activity
    U Brand
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Gyrhofstrabetae 17, D 50923 Köln, Germany
    Science 289:617-9. 2000
    ..fate of stem cells in plant meristems is governed by directional signaling systems that are regulated by negative feedback. In Arabidopsis thaliana, the CLAVATA (CLV) genes encode the essential components of a negative, stem cell-..
  17. pmc puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in Drosophila
    E Martin-Blanco
    Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK
    Genes Dev 12:557-70. 1998
    ..a consequence of the activity of the JNK pathway and that during dorsal closure, JNK signaling has a dual role: to activate an effector, encoded by decapentaplegic, and an element of negative feedback regulation encoded by puckered.
  18. pmc Impact of workplace based assessment on doctors' education and performance: a systematic review
    Alice Miller
    Peninsula College of Medicine and Dentistry, University of Plymouth, Plymouth PL4 8AA, UK
    BMJ 341:c5064. 2010
    ..To investigate the literature for evidence that workplace based assessment affects doctors' education and performance...
  19. ncbi Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation
    C Meno
    Division of Molecular Biology, Osaka University, Japan
    Mol Cell 4:287-98. 1999
    ..Expression of antivin is dependent on Nodal signaling, revealing a feedback loop wherein Nodal signals induce their antagonists Lefty2 and Antivin to restrict Nodal signaling during ..
  20. ncbi Chronic stress promotes palatable feeding, which reduces signs of stress: feedforward and feedback effects of chronic stress
    Norman Pecoraro
    Department of Physiology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, California 94143 0444
    Endocrinology 145:3754-62. 2004
    ..The results of this experiment tend to support our model of chronic effects of stress and GCs, showing a stressor-induced preference for comfort food, and a comfort-food reduction in activity of the HPA axis...
  21. ncbi Systematic review of the literature on assessment, feedback and physicians' clinical performance: BEME Guide No. 7
    Jon Veloski
    Center for Research in Medical Education and Health Care, Jefferson Medical College, Thomas Jefferson University, Philadelphia 19107, USA
    Med Teach 28:117-28. 2006
    There is a basis for the assumption that feedback can be used to enhance physicians' performance. Nevertheless, the findings of empirical studies of the impact of feedback on clinical performance have been equivocal.
  22. pmc Meta-analysis: audit and feedback features impact effectiveness on care quality
    Sylvia J Hysong
    Houston VA HSR and D Center of Excellence, Health Services Research and Development Service, Department of Veterans Affairs Medical Center, TX, USA
    Med Care 47:356-63. 2009
    Audit and feedback (A&F) has long been used to improve quality of care, albeit with variable results...
  23. pmc The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2
    F J Stott
    Imperial Cancer Research Fund Laboratories, P O Box 123, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    EMBO J 17:5001-14. 1998
    ..However, p14(ARF) expression is not involved in the response to DNA damage. These results place p14(ARF) in an independent pathway upstream of p53 and imply that CDKN2A encodes two proteins that are involved in tumour suppression...
  24. ncbi Sensory prediction errors drive cerebellum-dependent adaptation of reaching
    Ya weng Tseng
    Dept of Neurology, The Johns Hopkins School of Medicine, Kennedy Krieger Institute, Baltimore, MD 21205, USA
    J Neurophysiol 98:54-62. 2007
    ..Therefore adaptation to visuomotor perturbations depends on the cerebellum and is driven by the mismatch between predicted and actual sensory outcome of motor commands...
  25. pmc Feedback regulation in multistage cell lineages
    Wing Cheong Lo
    Departments of Mathematics, University of California, Irvine, CA, United States
    Math Biosci Eng 6:59-82. 2009
    ..self-renewal and differentiation of stem and progenitor cells within such lineages have been shown to be under feedback regulation...
  26. pmc Internet-based brief personalized feedback intervention in a non-treatment-seeking population of adult heavy drinkers: a randomized controlled trial
    Anders Blædel Gottlieb Hansen
    National Institute of Public Health, Faculty of Health Sciences, University of Southern Denmark, Copenhagen, Denmark
    J Med Internet Res 14:e98. 2012
    ..Internet-based interventions for heavy drinkers show promising results, but existing research is characterized by few studies in nonstudent adult populations and few comparisons with appropriate control groups...
  27. ncbi MiR-34, SIRT1 and p53: the feedback loop
    Munekazu Yamakuchi
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cell Cycle 8:712-5. 2009
    ..Based on this observation, we propose a positive feedback loop, in which p53 induces expression of miR-34a which suppresses SIRT1, increasing p53 activity.
  28. pmc A positive feedback loop involving Haspin and Aurora B promotes CPC accumulation at centromeres in mitosis
    Fangwei Wang
    Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Curr Biol 21:1061-9. 2011
    ..We propose that Aurora B activity triggers a CPC-Haspin-H3T3ph feedback loop that promotes generation of H3T3ph on chromatin...
  29. ncbi Spatio-temporal prediction modulates the perception of self-produced stimuli
    S J Blakemore
    Wellcome Department of Cognitive Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
    J Cogn Neurosci 11:551-9. 1999
    ..e., its tickliness) is proportional to the error between the sensory feedback predicted by an internal forward model of the motor system and the actual sensory feedback produced by the ..
  30. ncbi How emotion shapes behavior: feedback, anticipation, and reflection, rather than direct causation
    Roy F Baumeister
    Florida State University, Florida, USA
    Pers Soc Psychol Rev 11:167-203. 2007
    ..Instead, the authors develop a theory of emotion as a feedback system whose influence on behavior is typically indirect...
  31. ncbi The impact of feedback semantics in visual word recognition: number-of-features effects in lexical decision and naming tasks
    Penny M Pexman
    Department of Psychology, University of Calgary, Alberta, Canada
    Psychon Bull Rev 9:542-9. 2002
    The notion of feedback activation from semantics to both orthography and phonology has recently been used to explain a number of semantic effects in visual word recognition, including polysemy effects (Hino & Lupker, 1996; Pexman &..
  32. ncbi Inducible microRNA-155 feedback promotes type I IFN signaling in antiviral innate immunity by targeting suppressor of cytokine signaling 1
    Pin Wang
    National Key Laboratory of Medical Immunology, Institute of Immunology, Second Military Medical University, Shanghai, China
    J Immunol 185:6226-33. 2010
    ..And the inducible miR-155 feedback promotes type I IFN signaling, thus suppressing viral replication...
  33. ncbi Contribution of feedforward, lateral and feedback connections to the classical receptive field center and extra-classical receptive field surround of primate V1 neurons
    Alessandra Angelucci
    Department of Ophthalmology and Visual Science, Moran Eye Center, University of Utah, 50 North Medical Drive, Salt Lake City, UT 84132, USA
    Prog Brain Res 154:93-120. 2006
    ..Geniculocortical feedforward (FF), V1 lateral and extrastriate feedback (FB) connections to V1 could all contribute to generating the RF center and surround of V1 neurons...
  34. pmc MK2 controls the level of negative feedback in the NF-kappaB pathway and is essential for vascular permeability and airway inflammation
    Magdalena M Gorska
    Division of Allergy and Immunology, Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Exp Med 204:1637-52. 2007
    ..This pattern of activation is essential for many NF-kappaB-regulated genes and development of inflammation. Thus, the MK2-HSP27 pathway is an excellent target for therapeutic control of localized inflammatory diseases...
  35. pmc Written online situational feedback via mobile phone to support self-management of chronic widespread pain: a usability study of a Web-based intervention
    Ólöf Birna Kristjánsdóttir
    Faculty of Nursing, Oslo University College, Oslo, Norway
    BMC Musculoskelet Disord 12:51. 2011
    ..This pretrial study aimed to develop and test the usability of a four-week Internet intervention delivered by a Web-enabled mobile phone to support self-management of chronic widespread pain...
  36. ncbi The coordination of movement: optimal feedback control and beyond
    Jorn Diedrichsen
    Institute of Cognitive Neuroscience, University College London, Alexandra House, 17 Queens Square, London, UK
    Trends Cogn Sci 14:31-9. 2010
    Optimal control theory and its more recent extension, optimal feedback control theory, provide valuable insights into the flexible and task-dependent control of movements...
  37. ncbi Redundant pathways for negative feedback regulation of bile acid production
    Li Wang
    Department of Molecular and Cellular Biology, Houston, TX 77030, USA
    Dev Cell 2:721-31. 2002
    The orphan nuclear hormone receptor SHP has been proposed to have a key role in the negative feedback regulation of bile acid production...
  38. pmc Brief intervention for heavy-drinking college students: 4-year follow-up and natural history
    J S Baer
    Center of Excellence in Substance Abuse Treatment and Education, VA Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
    Am J Public Health 91:1310-6. 2001
    ..This study examined long-term response to an individual preventive intervention for high-risk college drinkers relative to the natural history of college drinking...
  39. ncbi Feedback and reward processing in high-functioning autism
    Michael J Larson
    Department of Psychology, Brigham Young University, Provo, UT 84602, USA
    Psychiatry Res 187:198-203. 2011
    ..Such deficits may be influenced by poor ability to process feedback and rewards...
  40. ncbi Control of Dpp morphogen signalling by a secreted feedback regulator
    Robin Vuilleumier
    Institute for Biology I, Albert Ludwigs University of Freiburg, Hauptstrasse 1, D 79104 Freiburg, Germany
    Nat Cell Biol 12:611-7. 2010
    ..We show that Pent interacts with the glypican Dally to control Dpp distribution and provide evidence that proper establishment of the BMP morphogen gradient requires the inbuilt feedback loop embodied by Pent.
  41. ncbi Competition between feedback loops underlies normal and pathological dynamics in the basal ganglia
    Arthur Leblois
    Laboratoire de Neurophysique et Physiologie du Système Moteur, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 8119, Universite Rene Descartes, 75270 Paris, France
    J Neurosci 26:3567-83. 2006
    ..the subthalamic nucleus, the internal pallidum (GPi), the thalamus, and the cortex are involved in closed feedback loops...
  42. ncbi A positive feedback loop coordinates growth and patterning in the vertebrate limb
    L Niswander
    Department of Anatomy, School of Medicine, University of California at San Francisco 94143 0452
    Nature 371:609-12. 1994
    ..Moreover, Shh expression in mesenchyme can be activated by FGF4 in combination with retinoic acid. Once induced, Shh expression can be maintained by FGF4 alone, thus establishing a positive feedback loop between ZPA and ridge.
  43. ncbi Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels
    P E Hardin
    Howard Hughes Medical Institute, Brandeis University, Waltham, Massachusetts 02254
    Nature 343:536-40. 1990
    ..The observations indicate that the cycling of per-encoded protein could result from per RNA cycling, and that there is a feedback loop through which the activity of per-encoded protein causes cycling of its own RNA.
  44. pmc IFN induces miR-21 through a signal transducer and activator of transcription 3-dependent pathway as a suppressive negative feedback on IFN-induced apoptosis
    Chuan He Yang
    Departments of Pathology and Laboratory Medicine and Physiology and Center for Integrative Cancer Research, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Cancer Res 70:8108-16. 2010
    ..Our results identify miR-21 as a novel IFN target gene that functions as a key feedback regulator of IFN-induced apoptosis.
  45. ncbi Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stress
    Yanjun Ma
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    J Biol Chem 278:34864-73. 2003
    ..Our study delineates a negative feedback regulatory loop in which the eIF-2 alpha-controlled inhibition of protein translation leads to GADD34 induction, ..
  46. ncbi Long-distance feedback projections to area V1: implications for multisensory integration, spatial awareness, and visual consciousness
    Simon Clavagnier
    INSERM U371, IFR19 corrected Université Claude Bernard Lyon 1, Bron, France
    Cogn Affect Behav Neurosci 4:117-26. 2004
    ..We have, therefore, reexamined feedback projections to area V1, using retrograde tracer injections in this area In addition to well-known areas, ..
  47. ncbi Perisomatic feedback inhibition underlies cholinergically induced fast network oscillations in the rat hippocampus in vitro
    Edward O Mann
    University Laboratory of Physiology, Oxford University, Parks Road, Oxford OX1 3PT, UK
    Neuron 45:105-17. 2005
    ..AMPA receptor-mediated recurrent excitation was necessary for the synchronization of interneuronal discharge, which strongly supports a synaptic feedback model for the generation of hippocampal gamma oscillations.
  48. ncbi PTH increases FGF23 gene expression and mediates the high-FGF23 levels of experimental kidney failure: a bone parathyroid feedback loop
    Vardit Lavi-Moshayoff
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew Univ Medical Center, PO Box 12000, Jerusalem, Israel 91120
    Am J Physiol Renal Physiol 299:F882-9. 2010
    ..The effect of PTH on FGF23 completes a bone-parathyroid endocrine feedback loop. Importantly, secondary hyperparathyroidism is essential for the high-FGF23 levels in early CKD.
  49. pmc Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein
    Elena Tamagno
    Department of Experimental Medicine and Oncology, University of Torino, Torino, Italy
    J Neurochem 104:683-95. 2008
    ..Our findings suggest a mechanism by which OS induces BACE1 transcription, thereby promoting production of pathological levels of amyloid beta in AD...
  50. pmc Feedback control of the protein kinase TAK1 by SAPK2a/p38alpha
    Peter C F Cheung
    MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, Dow Street, University of Dundee, Dundee DD1 5EH, UK
    EMBO J 22:5793-805. 2003
    ..Our results suggest that TAB1 participates in a SAPK2a/p38alpha-mediated feedback control of TAK1, which not only limits the activation of SAPK2a/p38alpha but synchronizes its activity with other ..
  51. ncbi Axon sprouting in a model of temporal lobe epilepsy creates a predominantly excitatory feedback circuit
    Paul S Buckmaster
    Department of Comparative Medicine, Stanford University School of Medicine, Stanford, California 94305 5330, USA
    J Neurosci 22:6650-8. 2002
    ..Rather, it replaces a distally distributed and disynaptic excitatory feedback circuit with one that is local and monosynaptic.
  52. ncbi Effects of correct and transformed visual feedback on rhythmic visuo-motor tracking: tracking performance and visual search behavior
    M Roerdink
    Institute for Fundamental and Clinical Human Movement Sciences, Faculty of Human Movement Sciences, Vrije Universiteit, 1081BT Amsterdam, The Netherlands
    Hum Mov Sci 24:379-402. 2005
    The effects of correct and transformed visual feedback on rhythmic unimanual visuo-motor tracking were examined, focusing on tracking performance (accuracy and stability) and visual search behavior...
  53. ncbi The development of computer-generated tailored interventions
    A Dijkstra
    Department of Clinical and Health Psychology, Leiden University, P O Box 9555, 2300 RB, Leiden, Netherlands
    Patient Educ Couns 36:193-203. 1999
    ..This methodology may result in largely different tailored interventions depending on the theoretical framework used, the adaptation of the messages and the inclusion of feedback.
  54. pmc Neural mechanisms underlying auditory feedback control of speech
    Jason A Tourville
    Department of Cognitive and Neural Systems, Boston University, 677 Beacon St, Boston, MA 02215, USA
    Neuroimage 39:1429-43. 2008
    The neural substrates underlying auditory feedback control of speech were investigated using a combination of functional magnetic resonance imaging (fMRI) and computational modeling...
  55. ncbi Neural correlates of verbal feedback processing: an fMRI study employing overt speech
    Ingrid K Christoffels
    Department of Cognitive Neuroscience, Faculty of Psychology, Maastricht University, The Netherlands
    Hum Brain Mapp 28:868-79. 2007
    Speakers use external auditory feedback to monitor their own speech. Feedback distortion has been found to increase activity in the superior temporal areas...
  56. ncbi vrille, Pdp1, and dClock form a second feedback loop in the Drosophila circadian clock
    Shawn A Cyran
    Department of Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Cell 112:329-41. 2003
    The Drosophila circadian clock consists of two interlocked transcriptional feedback loops. In one loop, dCLOCK/CYCLE activates period expression, and PERIOD protein then inhibits dCLOCK/CYCLE activity...
  57. ncbi User testing and stakeholder feedback contributed to the development of understandable and useful Summary of Findings tables for Cochrane reviews
    Sarah E Rosenbaum
    Norwegian Knowledge Centre for the Health Services, St Olavs Plass, Oslo, Norway
    J Clin Epidemiol 63:607-19. 2010
    ..To develop a Summary of Findings (SoF) table for use in Cochrane reviews that is understandable and useful for health professionals, acceptable to Cochrane Collaboration stakeholders, and feasible to implement...
  58. ncbi A fast, robust and tunable synthetic gene oscillator
    Jesse Stricker
    Department of Bioengineering, University of California, San Diego, La Jolla, California 92093, USA
    Nature 456:516-9. 2008
    ..oscillator was designed using a previously modelled network architecture comprising linked positive and negative feedback loops...
  59. ncbi Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin
    E Carballo
    Office of Clinical Research and Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Science 281:1001-5. 1998
    ..These findings identify TTP as a component of a negative feedback loop that interferes with TNF-alpha production by destabilizing its messenger RNA...
  60. ncbi What is feedback in clinical education?
    J M Monica van de Ridder
    Centre for Research and Development, University Medical Centre Utrecht, Utrecht, The Netherlands
    Med Educ 42:189-97. 2008
    b>Feedback is important in clinical education. However, the medical education literature provides no consensual definition of feedback...
  61. pmc A systematic review of the use of theory in randomized controlled trials of audit and feedback
    Heather L Colquhoun
    Ottawa Hospital Research Institute, Clinical Epidemiology Program, The Ottawa Hospital, General Campus, 501 Smyth Road, Centre for Practice Changing Research, Box 201B, Ottawa, Ontario K1H 8L6, Canada
    Implement Sci 8:66. 2013
    Audit and feedback is one of the most widely used and promising interventions in implementation research, yet also one of the most variably effective...
  62. ncbi Effects of remote feedback in home-based physical activity interventions for older adults: a systematic review
    Hilde Geraedts
    Center for Human Movement Sciences, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Patient Educ Couns 91:14-24. 2013
    To evaluate the literature on effectiveness of remote feedback on physical activity and capacity in home-based physical activity interventions for older adults with or without medical conditions...
  63. pmc Factors contributing to inappropriate ordering of tests in an academic medical department and the effect of an educational feedback strategy
    Spiros Miyakis
    Third Department of Internal Medicine, University of Athens, Sotiria General Hospital, Athens, Greece
    Postgrad Med J 82:823-9. 2006
    To identify factors contributing to laboratory overutilisation in an academic medical department, and to assess the effect of an educational feedback strategy on inappropriate test-ordering behaviour.
  64. ncbi Separable neural mechanisms contribute to feedback processing in a rule-learning task
    K Zanolie
    Leiden University Institute for Psychological Research LU IPR, Leiden University, The Netherlands
    Neuropsychologia 46:117-26. 2008
    ..appropriately to environmental demands, it is important to monitor ongoing action and process performance feedback for possible errors...
  65. ncbi Faculty staff perceptions of feedback to residents after direct observation of clinical skills
    Jennifer R Kogan
    Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Med Educ 46:201-15. 2012
    ..Given the inaccuracy of self-assessment, the provision of external feedback to residents about their clinical skills is necessary for the development of expertise...
  66. pmc Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion
    Thomas M Kitzing
    Institute of Pharmacology, University of Heidelberg, 69120 Heidelberg, Germany
    Genes Dev 21:1478-83. 2007
    ..Our results reveal that Dia1 is necessary for LPA-stimulated Rho/ROCK signaling and bleb-associated cancer cell invasion. Thus, Dia1-dependent RhoA activation constitutes a positive feedback mechanism to modulate cell behavior.
  67. pmc Mechanical feedback as a possible regulator of tissue growth
    Boris I Shraiman
    Kavli Institute for Theoretical Physics, Kohn Hall, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 102:3318-23. 2005
    ..stress, and we propose that dependence of the rate of cell division on local stress could provide an "integral-feedback" mechanism stabilizing uniform growth...
  68. ncbi Visual feedback distortion in a robotic environment for hand rehabilitation
    Bambi Roberts Brewer
    Carnegie Mellon University, Pittsburgh, PA, United States
    Brain Res Bull 75:804-13. 2008
    ..Our research uses a paradigm called visual feedback distortion in which the visual feedback corresponding to force or distance is gradually changed by an ..
  69. pmc Enhanced negative feedback responses in remitted depression
    Diane L Santesso
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Neuroreport 19:1045-8. 2008
    Major depressive disorder (MDD) is characterized by hypersensitivity to negative feedback that might involve frontocingulate dysfunction...
  70. pmc Multiple parietal reach regions in humans: cortical representations for visual and proprioceptive feedback during on-line reaching
    Flavia Filimon
    Department of Cognitive Science, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 29:2961-71. 2009
    Reaching toward a visual target involves at least two sources of information. One is the visual feedback from the hand as it approaches the target...
  71. ncbi Feedforward, horizontal, and feedback processing in the visual cortex
    V A Lamme
    Graduate School of Neurosciences, Department of Medical Physics, University of Amsterdam, The Netherlands
    Curr Opin Neurobiol 8:529-35. 1998
    ..These modulations reflect lateral interactions within areas and feedback from higher to lower areas...
  72. ncbi Frequency control of motor patterning by negative sensory feedback
    Jessica Ausborn
    Institute of Neurobiology, Ulm University, D 89069 Ulm, Germany
    J Neurosci 27:9319-28. 2007
    ..key role in the generation of behavior by providing the nervous system with information about the environment and feedback about body movements such that motor output can continuously be adapted to changing circumstances...
  73. pmc Vocalization-induced enhancement of the auditory cortex responsiveness during voice F0 feedback perturbation
    Roozbeh Behroozmand
    Speech Physiology Laboratory, Department of Communication Science and Disorders, Northwestern University, 2240 Campus Drive, Evanston, IL 60208, USA
    Clin Neurophysiol 120:1303-12. 2009
    The present study investigated whether self-vocalization enhances auditory neural responsiveness to voice pitch feedback perturbation and how this vocalization-induced neural modulation can be affected by the extent of the feedback ..
  74. ncbi Learning-induced enhancement of feedback inhibitory synaptic transmission
    Inbar Brosh
    Departments of Neurobiology and Biology, Faculty of Sciences, University of Haifa 31905, Israel
    Learn Mem 16:413-6. 2009
    ..We suggest that learning is accompanied by long-lasting enhancement of synaptic inhibition onto excitatory neurons, thus compensating for the increase of excitation in these neurons...
  75. pmc Self-esteem modulates medial prefrontal cortical responses to evaluative social feedback
    Leah H Somerville
    Department of Psychological and Brain Sciences, Center for Cognitive Neuroscience, Dartmouth College, Hanover, NH 03755, USA
    Cereb Cortex 20:3005-13. 2010
    ..As such, self-esteem may bias neural responses to positive and negative social feedback across individuals...
  76. ncbi It was not MY fault: event-related brain potentials in active and observational learning from feedback
    Christian Bellebaum
    Institute of Cognitive Neuroscience, Department of Neuropsychology, Ruhr University of Bochum, Universitaetsstraße 150, Bochum, Germany
    Cereb Cortex 20:2874-83. 2010
    Performance feedback during learning is accompanied by a negative event-related potentials (ERP) component, the feedback-related negativity (FRN), which codes a reward prediction error...
  77. ncbi p21(WAF1) is component of a positive feedback loop that maintains the p53 transcriptional program
    Lisa Y Pang
    CRUK Cell Signalling Unit, Institute of Genetics and Molecular Medicine, Edinburgh, Scotland, UK
    Cell Cycle 10:932-50. 2011
    The regulation of p53 activity through the MDM2 negative feedback loop is driven in part by an extrinsic ATM-pulse that maintains p53 oscillations in response to DNA damage...
  78. ncbi Neural correlates of auditory feedback control in human
    A Toyomura
    Research Institute of Science and Technology for Society, Japan Science and Technology Agency, Japan
    Neuroscience 146:499-503. 2007
    Auditory feedback plays an important role in natural speech production...
  79. ncbi CPR quality improvement during in-hospital cardiac arrest using a real-time audiovisual feedback system
    Benjamin S Abella
    Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Resuscitation 73:54-61. 2007
    ..We hypothesized that real-time feedback during CPR would improve the performance of chest compressions and ventilations during in-hospital cardiac arrest.
  80. pmc Translational feedback regulation of the gene for L35 in Escherichia coli requires binding of ribosomal protein L20 to two sites in its leader mRNA: a possible case of ribosomal RNA-messenger RNA molecular mimicry
    Maude Guillier
    Institut de Biologie Physico Chimique, Unité Propre de Recherche 9073 du Centre National de la Recherche Scientifique, Paris, France
    RNA 8:878-89. 2002
    ..However L20 can bind to each site independently in vitro. One site is similar to the L20-binding site on 23S rRNA. Here we propose that L20 recognizes its mRNA and its rRNA in similar way...
  81. ncbi Effective desynchronization by nonlinear delayed feedback
    Oleksandr V Popovych
    Institute of Medicine, Research Center Julich, 52425 Julich, Germany
    Phys Rev Lett 94:164102. 2005
    We show that nonlinear delayed feedback opens up novel means for the control of synchronization. In particular, we propose a demand-controlled method for powerful desynchronization, which does not require any time-consuming calibration...
  82. ncbi Contribution of sensory feedback to ongoing ankle extensor activity during the stance phase of walking
    J Maxwell Donelan
    Department of Physiology, Centrre for Neuroscience, University of Alberta, Edmonton T6G 2H7, Alberta, Canada
    Can J Physiol Pharmacol 82:589-98. 2004
    Numerous investigations over the past 15 years have demonstrated that sensory feedback plays a critical role in establishing the timing and magnitude of muscle activity during walking...
  83. ncbi Social feedback and the emergence of leaders and followers
    Jennifer L Harcourt
    Department of Zoology, University of Cambridge, Cambridge, UK
    Curr Biol 19:248-52. 2009
    ..We conclude that leadership in this case is reinforced by positive social feedback.
  84. ncbi Postnatal maternal separation during the stress hyporesponsive period enhances the adrenocortical response to novelty in adult rats by affecting feedback regulation in the CA1 hippocampal field
    G Biagini
    Department of Biomedical Sciences, University of Modena, Italy
    Int J Dev Neurosci 16:187-97. 1998
    ....
  85. ncbi Human glucocorticoid feedback inhibition is reduced in older individuals: evening study
    C W Wilkinson
    Geriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington 98108, USA
    J Clin Endocrinol Metab 86:545-50. 2001
    ..To confirm this finding and to determine whether aging-related changes in feedback responsiveness are exaggerated near the time of the circadian nadir in adrenocortical secretion, we performed a ..
  86. pmc Individual-level interventions to reduce college student drinking: a meta-analytic review
    Kate B Carey
    Center for Health and Behavior, Syracuse University, Syracuse, NY 13244 2340, USA
    Addict Behav 32:2469-94. 2007
    ..suggest that individual, face-to-face interventions using motivational interviewing and personalized normative feedback predict greater reductions in alcohol-related problems...
  87. pmc CKI and CKII mediate the FREQUENCY-dependent phosphorylation of the WHITE COLLAR complex to close the Neurospora circadian negative feedback loop
    Qun He
    Department of Physiology, The University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Genes Dev 20:2552-65. 2006
    The eukaryotic circadian oscillators consist of circadian negative feedback loops. In Neurospora, it was proposed that the FREQUENCY (FRQ) protein promotes the phosphorylation of the WHITE COLLAR (WC) complex, thus inhibiting its activity...
  88. ncbi Improving quality improvement using achievable benchmarks for physician feedback: a randomized controlled trial
    C I Kiefe
    University of Alabama at Birmingham, 1717 11th Ave S, MT 700, Birmingham, AL 35205 4785, USA
    JAMA 285:2871-9. 2001
    Performance feedback and benchmarking, common tools for health care improvement, are rarely studied in randomized trials...
  89. ncbi Brain states: top-down influences in sensory processing
    Charles D Gilbert
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Neuron 54:677-96. 2007
    ..are determined by the interactions between multiple cortical areas and the modulation of intrinsic circuits by feedback connections...
  90. ncbi The effects of spike frequency adaptation and negative feedback on the synchronization of neural oscillators
    B Ermentrout
    Department of Mathematics, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neural Comput 13:1285-310. 2001
    ..The shunting behavior is captured in a simple two-variable reduced model that arises near certain types of bifurcations. A one-dimensional map is derived from the simplified model...
  91. ncbi Self-controlled feedback is effective if it is based on the learner's performance
    Suzete Chiviacowsky
    School of Physical Education, Federal University of Pelotas, Brazil
    Res Q Exerc Sport 76:42-8. 2005
    The study follows up on the contention that self-controlled feedback schedules benefit learning because they are more tailored to the performers' needs than externally controlled feedback schedules (Chiviacowsky & Wulf, 2002)...
  92. pmc Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung
    Pao Tien Chuang
    Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    Genes Dev 17:342-7. 2003
    ..Our studies focused on Hip1 in the lung. Here, a dynamic interaction between Hh and fibroblast growth factor (Fgf) signaling, modulated at least in part by Hip1, controls early lung branching...
  93. ncbi Adaptation to visual feedback delays in manual tracking: evidence against the Smith Predictor model of human visually guided action
    R C Miall
    Behavioural Brain Sciences, School of Psychology, University of Birmingham, B15 2TT Birmingham, UK
    Exp Brain Res 172:77-84. 2006
    We report adaptation to delayed visual feedback during a manual tracking task, testing the nature of the adapted responses with frequency analysis...
  94. ncbi Dorsal anterior cingulate cortex shows fMRI response to internal and external error signals
    Clay B Holroyd
    Department of Psychology, Green Hall, Princeton University, Princeton, New Jersey 08544, USA
    Nat Neurosci 7:497-8. 2004
    ..imaging (fMRI) experiment, participants learned to select between two response options by trial-and-error, using feedback stimuli that indicated monetary gains and losses...
  95. ncbi Postural feedback responses scale with biomechanical constraints in human standing
    Sukyung Park
    Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109 2125, USA
    Exp Brain Res 154:417-27. 2004
    We tested whether human postural responses can be described in terms of feedback control gains, and whether these gains are scaled by the central nervous system to accommodate biomechanical constraints...
  96. pmc Positive feedback and noise activate the stringent response regulator rel in mycobacteria
    Kamakshi Sureka
    Department of Chemistry, Bose Institute, Kolkata, India
    PLoS ONE 3:e1771. 2008
    ..two distinct peaks corresponding to low (L) and high (H) expression states, and further establish that a positive feedback loop involving the mprAB operon along with stochastic gene expression are responsible for the phenotypic ..
  97. pmc Thyroid hormone exerts negative feedback on hypothalamic type 4 melanocortin receptor expression
    Stéphanie Decherf
    Departement Regulations, Centre National de la Recherche Scientifique Unité Mixte de Recherche 7221, Evolution des Regulations Endocriniennes, Museum national d histoire naturelle, Paris, France
    Proc Natl Acad Sci U S A 107:4471-6. 2010
    ..These facts led us to test the hypothesis that energy homeostasis should require negative feedback by T(3) on Mc4r expression...
  98. pmc Spatial positive feedback at the onset of mitosis
    Silvia D M Santos
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
    Cell 149:1500-13. 2012
    ..Positive feedback loops regulate the activation of Cdk1-cyclin B1 and help make the process irreversible and all-or-none in ..
  99. ncbi A systematic review of selected interventions for worksite health promotion. The assessment of health risks with feedback
    Robin E Soler
    National Center for Health Marketing, CDC, Atlanta, Georgia 30333, USA
    Am J Prev Med 38:S237-62. 2010
    ..report provides recommendations on the effectiveness of interventions that use an Assessment of Health Risks with Feedback (AHRF) when used alone or as part of a broader worksite health promotion program to improve the health of ..
  100. ncbi Training with virtual visual feedback to alleviate phantom limb pain
    Catherine Mercier
    Center for Cognitive Neuroscience, Bron, France
    Neurorehabil Neural Repair 23:587-94. 2009
    Performing phantom movements with visual virtual feedback, or mirror therapy, is a promising treatment avenue to alleviate phantom limb pain. However the effectiveness of this approach appears to vary from one patient to another.
  101. ncbi Error and feedback processing in children with ADHD and children with Autistic Spectrum Disorder: an EEG event-related potential study
    Yvonne Groen
    Department of Psychiatry, University Medical Center Groningen, University of Groningen, P O Box 660, 9700 AR Groningen, The Netherlands
    Clin Neurophysiol 119:2476-93. 2008
    ....

Research Grants77

  1. Adjuvant Treatment Decision Making for Lung Cancer
    Jamie Studts; Fiscal Year: 2006
    ..Only when patients understand the necessary information about the risks and benefits of each treatment option will they be able to make informed treatment decisions that are consistent with their values. [unreadable] [unreadable]..
  2. Ensemble Disruption of the GnRH-LH-Testosterone Axis
    Johannes Veldhuis; Fiscal Year: 2007
    ..Interpreted from this vantage, published literature, laboratory experiments, background data and ensemble feedback/feed forward simulations predict that hydroandrogenemia in aging men could arise nonexclusively by way of: (i) ..
  3. Mechanistic bases for age-related androgen deficiency
    Johannes Veldhuis; Fiscal Year: 2007
    ..HYPOTHESIS III: Reduced negative feedback by testosterone, which unleashes high-frequency, low- amplitude and irregular LH release...
  4. THE AGING GH AXIS IN POSTMENOPAUSAL WOMEN
    Johannes Veldhuis; Fiscal Year: 2005
    ..Hypothesis III: Estrogen add back can override GH's autonegative feedback restraint of GH secretion...
  5. ENSEMBLE MODEL OF STRESS ACTH-ADRENAL AXIS
    Johannes Veldhuis; Fiscal Year: 2005
    ..sheep, horse and human, the stress-responsive corticotropic-adrenal axis can be viewed as a dynamically adaptive feedback system supervised by key brain (hypothalamic) regulatory centers...
  6. Analytical Reconstruction of Feedback Signaling in Aging Men
    Johannes Veldhuis; Fiscal Year: 2008
    ..provided by applicant): Self-adaptive (homeostatic) biological systems operate via repeated incremental feedback and feed forward signaling adjustments to maintain species, gender and age-defined physiological norms...
  7. An Internet-based intervention for problem drinking
    John Cunningham; Fiscal Year: 2008
    ..be randomly assigned to be sent a World Wide Web page Internet address and password for the personalized alcohol feedback program or to a no intervention control group...
  8. Motion Sensor Array for Vestibular-deficient Individuals
    Conrad Wall; Fiscal Year: 2005
    ....
  9. Patient Feedback Effectiveness Study
    Paul Crits Christoph; Fiscal Year: 2008
    ..The proposed study tests the effectiveness of one Ql system - Patient Feedback (PF) - at increasing outpatient group therapy attendance and self-reported abstinence...
  10. Combined Treatment for GAD
    Paul Crits Christoph; Fiscal Year: 2008
    ..Data analysis will focus on differential rate of change (mixed model analyses) for the two groups. If promising results are obtained for combined treatment, a larger more definitive trial will be planned. [unreadable] [unreadable]..
  11. NEURAL MECHANISMS OF CUTANEOUS SPATIAL INTEGRATION
    ESTHER GARDNER; Fiscal Year: 2008
    ..activity in S-I confirms or rebuts the subject[unreadable]s expectation of haptic features, and provides feedback needed for error correction...
  12. Skill acquisition in older adults
    Rachael Seidler; Fiscal Year: 2009
    ....
  13. NEUROINFORMATICS AND EYE-HAND COORDINATION
    ESTHER GARDNER; Fiscal Year: 2005
    ....
  14. Persistence and Desistence in Heavy Drinking and Violence
    Helene R White; Fiscal Year: 2010
    ..Within a 2-year period, we will be able to make a significant contribution to the scholarly literature and provide data to be used in the development of targeted pre,vention programs. ..
  15. COMMUNITY-FRIENDLY MANUAL GUIDED DRUG COUNSELING
    Paul Crits Christoph; Fiscal Year: 2004
    ..The proposed treatment development work will include (1) obtaining feedback on the new treatment manuals by a sample of 15 community-based drug counselors, (2) evaluating whether a group of ..
  16. A Spiking Model of Hippocampus for Guiding Behavior
    Michael Hasselmo; Fiscal Year: 2006
    ..U., which focuses on modeling operant tasks used in experimental studies of drug self-administration phenomena, in work supported by a supplement to a previous grant from NIDA. [unreadable] [unreadable]..
  17. Female Anti-Problem Drinking Group & Campus Initiatives
    Joseph LaBrie; Fiscal Year: 2006
    ..Campus awareness will increase and campus culture will be changed. Evaluation/analysis plan is included. ..
  18. Reducing Antimicrobial Use Associated with Ventilator Associated Pneumonia and Ca
    SARA ELIZABETH COSGROVE; Fiscal Year: 2010
    ..and guidelines for catheter removal and dissemination of these materials via pocket cards and posters as well as feedback both to individual physicians about appropriate use of catheters and antimicrobials and to nurses regarding ..
  19. The Process of Group Therapy for Cocaine Dependence
    Paul Crits Christoph; Fiscal Year: 2007
    ..degree of patient participation, quality of participation, quality of the therapeutic alliance, and frequency of feedback (and positive feedback), as assessed in group drug counseling sessions, as predictors of treatment outcome...
  20. THERAPY DEVELOPMENT FOR MENTALLY ILL DRUG ABUSERS
    Kate Carey; Fiscal Year: 2003
    ..This award would allow the applicant protected time (teaching relief and summer support) to continue to develop her research on the treatment of substance abuse among the severely mentally ill. ..
  21. Portable low-cost glove for functional hand measures
    LISA SIMONE; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  22. Examining Psychosocial Mediators of Exercise Behavior
    Beth Lewis; Fiscal Year: 2007
    ..theoretical constructs) are most effective for increasing physical activity, which will have an important public health impact given that this will likely lead to more efficacious and less costly interventions. [unreadable] [unreadable]..
  23. Cognitive Neurogenetics of Schizophrenia
    Cameron Carter; Fiscal Year: 2008
    ..The work proposed in this application has the potential to have important implications for developing behavioral genetic tools to isolate the genes that cause schizophrenia. ..
  24. Alcohol Research Collabortive: Peer Programs
    Mary Larimer; Fiscal Year: 2007
    ..the efficacy of the Alcohol EDU web-based educational intervention in comparison to web-delivered motivational feedback and assessment-only, in reducing alcohol use and consequences of high-risk freshmen; 3) Test the longer-term ..
  25. Clinical Investigation of E.coli Biofilm Formation in the Human Bladder
    BARBARA TRAUTNER; Fiscal Year: 2007
    ..No effective strategy exists to prevent CAUTI in persons who require ongoing catheter use. Identifying genes that are required to cause CAUTI will lead to new strategies to prevent this illness. [unreadable] [unreadable] [unreadable]..
  26. Reflex control of multi-joint mechanics following stroke
    ERIC PERREAULT; Fiscal Year: 2007
    ..A small, complementary animal study will be performed to investigate possible mechanisms underlying the actions of tizanidine. [unreadable] [unreadable]..
  27. Steering Flexible Needles in Soft Tissue
    ALLISON MARIKO OKAMURA; Fiscal Year: 2010
    ....
  28. Randomized Trial of Tinnitus Retraining Therapy
    Richard Tyler; Fiscal Year: 2008
    ..If TRT is shown to be no more effective than masking or counseling, professionals should focus on more efficient therapeutic techniques. This experiment will test the neurophysiological model of tinnitus. [unreadable] [unreadable]..
  29. Dietary Adherence Enhancement in Peritoneal Dialysis
    MARY SEVICK; Fiscal Year: 2007
    ..Measurements will occur as baseline, 4 months, and 8 months for both groups. [unreadable] [unreadable]..
  30. Untethered Home Therapy System
    JOSEPH GIUFFRIDA; Fiscal Year: 2008
    ..By monitoring EMG and kinetic signals we will discriminate therapy tasks, monitor compliance time, and provide feedback. Additionally, movements, coordination patterns, and/or EMG will be used as inputs to an algorithm trained to ..
  31. Evaluating Nicotine Lozenges for Treatment of Smokeless Tobacco Addiction
    Jon Ebbert; Fiscal Year: 2009
    ..No drug therapies have been shown to be effective for helping smokeless tobacco users quit for good. The purpose of this study is to test drugs that can be used to help smokeless tobacco users quit for good. ..
  32. Modeling the Role of Priming in Executive Control
    Gordon Logan; Fiscal Year: 2009
    ..The first aim will establish the validity of the model, the second will establish its limits and set the stage for a general model of executive control. ..
  33. Treatment and/or Prevention of Urinary Tract Infections
    BARBARA TRAUTNER; Fiscal Year: 2008
    ..An agent to prevent and treat UTI that does not encourage microbial resistance would have a significant impact on public health. [unreadable] [unreadable] [unreadable]..
  34. The Value of CPOE in Pediatric Inpatient Units and Its Impact on Safety and Work
    Ben Tzion Karsh; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  35. Improving Weight Loss Outcomes in African Americans
    Jamy Ard; Fiscal Year: 2008
    ..The proposed training and research will provide Dr. Ard with the necessary skills and experience to advance his career to an independent investigator in obesity in special populations such as African Americans. ..
  36. Electrocorticographic Study of Categorical Phoneme Perception in the Human Tempor
    Edward Chang; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  37. Theoretical analysis of the effects of aging on memory and reaction time
    Roger Ratcliff; Fiscal Year: 2010
    ....
  38. Treatment of Child Physical Abuse: An Effectiveness Trial
    David Kolko; Fiscal Year: 2010
    ..This study will provide initial data on the transportability and adoption of EBTs in community settings serving the child welfare system. ..
  39. Regulation of vascular smooth muscle calcium sensitivity
    Paul H Ratz; Fiscal Year: 2010
    ..The Specific Aim of this study will be to test the hypothesis that ROK and PKCzeta both mediate KCI- induced Ca sensitization of FA, and that iPLA2 and PI3K are required as upstream activators of ROK and PKCzeta. ..
  40. Novel Active Repressor Model of Human LDL-Receptor Regulation
    Johannes Veldhuis; Fiscal Year: 2008
    ..This would represent a new treatment approach for patients with atherosclerotic disease. [unreadable] [unreadable] [unreadable] [unreadable]..
  41. Cerebromicrovascular disease in elderly with diabetes
    Vera Novak; Fiscal Year: 2010
    ..This study will provide new data and biomarkers on cerebral perfusion and functional outcomes in type 2 DM, that can be used to initialize the efforts to implement brain protection as a new target for prevention of DM complications. ..
  42. Synaptic plasticity in the medial superior olive
    LUISA SCOTT; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  43. Adenosine and Nitric Oxide Deficiency
    Italo Biaggioni; Fiscal Year: 2004
    ....
  44. REGULATION OF DETRUSOR SMOOTH MUSCLE CONTRACTION
    PAUL RATZ; Fiscal Year: 2005
    ..Collectively, these studies will provide new insights into the cellular mechanisms regulating DSM contractions. ..
  45. EGO DEPLETION PATTERNS AND SELF-CONTROL FAILURE
    ROY BAUMEISTER; Fiscal Year: 2001
    ..The fourth section will explore several implications and applications of the depletion of self: vulnerability to loss of self-esteem from ego threat; prejudice; procrastination; and overeating. ..
  46. ENHANCING ADHD RX EFFECTIVENESS BY PEDIATRICS & SCHOOLS
    Leonard Bickman; Fiscal Year: 2001
    ..An important element of this study is that it will not only examine the effectiveness of the intervention on individual children but will examine the effect community-wide. ..
  47. CUTANEOUS CONTROL OF EXPLORATORY HAND MOVEMENT
    ALLAN SMITH; Fiscal Year: 2001
    ..Prehensile movements of the hand use cutaneous feedback to adjust grip forces to the weight and friction of a handled object to minimize slip on the skin...
  48. IMPROVING PEDIATRICIANS' USE OF AD/HD GUIDELINES
    Leonard Bickman; Fiscal Year: 2003
    ....
  49. PHARMACOLOGIC PROBES IN NEURALLY-MEDIATED SYNCOPE
    Italo Biaggioni; Fiscal Year: 2003
    ..These studies will be directly applicable to the evaluation and treatment of patients with these incapacitating disorders. ..
  50. ADULT NEUROGENESIS & VOCAL PLASTICITY IN SONGBIRDS
    LUISA SCOTT; Fiscal Year: 2003
    ..abstract_text> ..
  51. NEURONAL ORGANIZATION OF BASAL GANGLIA
    Charles Wilson; Fiscal Year: 2003
    ..This latter will allow us to determine whether there is an actual mismatch between physiological and anatomical estimates of connectivity (i.e. non-functional synaptic connections). ..
  52. Metacognition and Control in Human Learning Memory
    JANET A METCALFE; Fiscal Year: 2010
    ....
  53. ACTIONS OF ESTROGEN IN MATURING GRAAFIAN FOLLICLES
    Johannes Veldhuis; Fiscal Year: 2005
    ..Understanding such fundamental interactions is important to the rational design of alternative strategies to interrupt normal and rescue impaired steroidogenesis in the maturing Graafian follicle and corpus luteum. ..
  54. Cognitive Neuroscience of Schizophrenia
    Cameron Carter; Fiscal Year: 2005
    ....
  55. Time course of learning perceptual pop-out in V1 and V2
    Matthew Smith; Fiscal Year: 2006
    ..In addition, knowledge of the limits of visual cortical plasticity are important in understanding diseases such as amblyopia, in which there are known changes in the cortex as a result of a visual impairment. ..
  56. Intelligent Task Assist Device for Motor Control in Cerebral Palsy
    JOSEPH GIUFFRIDA; Fiscal Year: 2006
    ..The system should help subjects complete activities of daily living, thereby increasing their independence and societal participation. [unreadable] [unreadable]..
  57. Dynamical Assessment of Cerebral Autoregulation
    Vera Novak; Fiscal Year: 2007
    ..Therefore, this project may have substantial socioeconomic impact. [unreadable] [unreadable] [unreadable]..
  58. COORDINATION OF SITTING UP
    Paul Cordo; Fiscal Year: 2001
    ..The vertical forces produced on the support surface will be recorded along with segmental kinematics and muscle (EMG) activity. ..
  59. Age Effects in Attention & Memory: Process Dissociations
    LARRY JACOBY; Fiscal Year: 2006
    ..The aim of experiments in that series is to show that changes in neural activation result from training that reduces age difference in vulnerability to interference...
  60. Functional Substrates of Long-Term Motor Learning
    Scott Grafton; Fiscal Year: 2006
    ..Specific Aim 1: Characterize the internal representation of a continuous motor skill as a function of feedback and control mechanisms. [unreadable] [unreadable] Specific Aim 2: Identify convergence of functional anatomy...
  61. PDE-5 Inhibition in HIV+ and HIV- Men
    Raymond Rosen; Fiscal Year: 2005
    ..Key personnel for the project are Raymond C. Rosen, Ph.D., Professor of Psychiatry and Medicine at UMDNJ, who will serve as PI, and Joseph Catania, PhD, co-PI, from the AIDS Research Institute at UCSF. ..
  62. Brief Dental Office Intervention with Tobacco Quitline
    Jon Ebbert; Fiscal Year: 2005
    ..S. adult population smoking; and 3) 75% of smokers quitting for at least one day or longer because they are trying to quit. ..
  63. Neural Systems Underlying Sign Language Production
    Karen Emmorey; Fiscal Year: 2009
    ..abstract_text> ..
  64. Volunteer Activities on Long-Term Care Residents
    Hon Yuen; Fiscal Year: 2002
    ..It is expected that findings will support the activity theory of aging and validate the beneficial effects of residents in LTC facilities participating in structured volunteer activities. ..
  65. Effectiveness Trial of Attention Shaping for Schizophrenia
    Steven M Silverstein; Fiscal Year: 2010
    ....
  66. Problem Solving Environment for Modeling the Cell Cycle
    John Tyson; Fiscal Year: 2002
    ..and some outstanding collaborators (Sible and Cross, experimental cell cycle research; Kitano and Bolouri, software development for molecular cell biology; and Kohn, bioinformatics of mammalian cell cycle controls). ..
  67. Oral Health in People with Systemic Sclerosis
    Hon Yuen; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  68. PITUITARY CELLS TO STUDY MALE INFERTILITY
    STEPHEN WINTERS; Fiscal Year: 2002
    ..abstract_text> ..
  69. G PROTEIN MEDIATED CA++ SENSITIZATION IN SMOOTH MUSCLE
    Toshio Kitazawa; Fiscal Year: 2002
    ....
  70. Mechanism of Ca2+ Sensitization in Smooth Muscle
    Toshio Kitazawa; Fiscal Year: 2006
    ..abstract_text> ..
  71. BEHAVIORAL/PHARMACOLOGIC TREATMENT OF ALCOHOLISM
    William Miller; Fiscal Year: 2004
    ..However, each study site has provided site-specific information on the budget, budget justifications, listing of key personnel, consultant/consortium agreements, and human subjects sections of their respective proposals. ..
  72. PROGRAMMATIC TREATMENT INNOVATION RESEARCH
    William Miller; Fiscal Year: 2004
    ..abstract_text> ..
  73. Proprioceptive feedback gain modulation during movement
    Mark Shapiro; Fiscal Year: 2008
    ..The two main mechanisms by which movement is produced are predictive feedforward control and sensory feedback control. The interplay of these two mechanisms in single-joint goal-oriented movements will be studied...
  74. MOVING MOTIVATIONAL INTERVIEWING INTO PRACTICE
    William Miller; Fiscal Year: 2002
    ..Two promising training enhancement procedures (individualized feedback to clinicians, and reinforced practice through individual consultations) will be evaluated via a design combining ..
  75. Acceptance Therapy During Methadone Detoxification
    Angela Stotts; Fiscal Year: 2007
    ..Effective treatment provided in conjunction with detoxification from agonist medication could result in significant decreases in the substantial health and social costs associated with chronic opiate dependence. ..