Genomes and Genes
Summary: A mechanism of communication within a system in that the input signal generates an output response which returns to influence the continued activity or productivity of that system.
Publications229 found, 100 shown here
- Optimal feedback control as a theory of motor coordinationEmanuel Todorov
Department of Cognitive Science, University of California, San Diego, 9500 Gilman Dr, La Jolla, California 92093 0515, USA
Nat Neurosci 5:1226-35. 2002..Here we propose an alternative theory based on stochastic optimal feedback control...
- MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammalsJohn Tsang
Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Mol Cell 26:753-67. 2007..Our results strongly suggest that coordinated transcriptional and miRNA-mediated regulation is a recurrent motif to enhance the robustness of gene regulation in mammalian genomes...
- A chemokine-driven positive feedback loop organizes lymphoid folliclesK M Ansel
Department of Microbiology and Immunology, University of California San Francisco, 94143, USA
Nature 406:309-14. 2000..a cytokine that promotes follicular dendritic cell development and BLC expression, establishing a positive feedback loop that is likely to be important in follicle development and homeostasis...
- Optimality principles in sensorimotor controlEmanuel Todorov
Department of Cognitive Science, University of California San Diego, La Jolla, California 92093 0515, USA
Nat Neurosci 7:907-15. 2004..Traditional emphasis has been on optimizing desired movement trajectories while ignoring sensory feedback. Recent work has redefined optimality in terms of feedback control laws, and focused on the mechanisms that ..
- The decision to enter mitosis: feedback and redundancy in the mitotic entry networkArne Lindqvist
Department of Medical Oncology, University Medical Center Utrecht, 3584 CG Utrecht, Netherlands
J Cell Biol 185:193-202. 2009..Within this network, several positive feedback loops can amplify cyclin B-Cdk1 activation to ensure complete commitment to a mitotic state once the decision to ..
- Delay in feedback repression by cryptochrome 1 is required for circadian clock functionMaki Ukai-Tadenuma
Laboratory for Systems Biology, RIKEN Center for Developmental Biology, Chuo Ku, Kobe, Hyogo, Japan
Cell 144:268-81. 2011Direct evidence for the requirement of delay in feedback repression in the mammalian circadian clock has been elusive...
- Engineering stability in gene networks by autoregulationA Becskei
EMBL, Structures and Biocomputing, Heidelberg, Germany
Nature 405:590-3. 2000..It has been proposed, but not demonstrated, that autoregulatory, negative feedback loops in gene circuits provide stability, thereby limiting the range over which the concentrations of network ..
- ERP correlates of feedback and reward processing in the presence and absence of response choiceNick Yeung
Department of Psychology, Princeton University, Princeton, NJ 08544, USA
Cereb Cortex 15:535-44. 2005The feedback negativity is a component of the event-related brain potential that is elicited by feedback stimuli associated with unfavorable outcomes...
- puckered encodes a phosphatase that mediates a feedback loop regulating JNK activity during dorsal closure in DrosophilaE Martin-Blanco
Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK
Genes Dev 12:557-70. 1998..a consequence of the activity of the JNK pathway and that during dorsal closure, JNK signaling has a dual role: to activate an effector, encoded by decapentaplegic, and an element of negative feedback regulation encoded by puckered.
- Feedback control of regulatory T cell homeostasis by dendritic cells in vivoGuillaume Darrasse-Jèze
Laboratory of Molecular Immunology, The Rockefeller University, New York, NY 10065, USA
J Exp Med 206:1853-62. 2009..We demonstrate the existence of a feedback regulatory loop between DCs and T reg cells...
- Using theory to synthesise evidence from behaviour change interventions: the example of audit and feedbackBenjamin Gardner
Centre for Outcomes Research and Effectiveness, University College London, 1 19 Torrington Place, London WC1E 7HB, UK
Soc Sci Med 70:1618-25. 2010..We illustrate this method with an analysis of 'audit and feedback' interventions, based on data from a Cochrane review...
- Impact of workplace based assessment on doctors' education and performance: a systematic reviewAlice Miller
Peninsula College of Medicine and Dentistry, University of Plymouth, Plymouth PL4 8AA, UK
BMJ 341:c5064. 2010..To investigate the literature for evidence that workplace based assessment affects doctors' education and performance...
- Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alphaI Novoa
Skirball Institute of Biomolecular Medicine, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
J Cell Biol 153:1011-22. 2001..These findings implicate GADD34-mediated dephosphorylation of eIF2alpha in a negative feedback loop that inhibits stress-induced gene expression, and that might promote recovery from translational inhibition ..
- Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor proteinElena Tamagno
Department of Experimental Medicine and Oncology, University of Torino, Torino, Italy
J Neurochem 104:683-95. 2008..Our findings suggest a mechanism by which OS induces BACE1 transcription, thereby promoting production of pathological levels of amyloid beta in AD...
- Sensory prediction errors drive cerebellum-dependent adaptation of reachingYa weng Tseng
Dept of Neurology, The Johns Hopkins School of Medicine, Kennedy Krieger Institute, Baltimore, MD 21205, USA
J Neurophysiol 98:54-62. 2007..Therefore adaptation to visuomotor perturbations depends on the cerebellum and is driven by the mismatch between predicted and actual sensory outcome of motor commands...
- The coordination of movement: optimal feedback control and beyondJorn Diedrichsen
Institute of Cognitive Neuroscience, University College London, Alexandra House, 17 Queens Square, London, UK
Trends Cogn Sci 14:31-9. 2010Optimal control theory and its more recent extension, optimal feedback control theory, provide valuable insights into the flexible and task-dependent control of movements...
- MiR-34, SIRT1 and p53: the feedback loopMunekazu Yamakuchi
Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Cell Cycle 8:712-5. 2009..Based on this observation, we propose a positive feedback loop, in which p53 induces expression of miR-34a which suppresses SIRT1, increasing p53 activity.
- Meta-analysis: audit and feedback features impact effectiveness on care qualitySylvia J Hysong
Houston VA HSR and D Center of Excellence, Health Services Research and Development Service, Department of Veterans Affairs Medical Center, TX, USA
Med Care 47:356-63. 2009Audit and feedback (A&F) has long been used to improve quality of care, albeit with variable results...
- A positive feedback loop involving Haspin and Aurora B promotes CPC accumulation at centromeres in mitosisFangwei Wang
Division of Rheumatology, Immunology and Allergy, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Curr Biol 21:1061-9. 2011..We propose that Aurora B activity triggers a CPC-Haspin-H3T3ph feedback loop that promotes generation of H3T3ph on chromatin...
- The p53 pathway: positive and negative feedback loopsSandra L Harris
The Cancer Institute of New Jersey and the Institute for Advanced Study, New Jersey, NJ, USA
Oncogene 24:2899-908. 2005..number of other signal transduction pathways in the cell and a number of positive and negative autoregulatory feedback loops act upon the p53 response...
- Contribution of feedforward, lateral and feedback connections to the classical receptive field center and extra-classical receptive field surround of primate V1 neuronsAlessandra Angelucci
Department of Ophthalmology and Visual Science, Moran Eye Center, University of Utah, 50 North Medical Drive, Salt Lake City, UT 84132, USA
Prog Brain Res 154:93-120. 2006..Geniculocortical feedforward (FF), V1 lateral and extrastriate feedback (FB) connections to V1 could all contribute to generating the RF center and surround of V1 neurons...
- Inducible microRNA-155 feedback promotes type I IFN signaling in antiviral innate immunity by targeting suppressor of cytokine signaling 1Pin Wang
National Key Laboratory of Medical Immunology, Institute of Immunology, Second Military Medical University, Shanghai, China
J Immunol 185:6226-33. 2010..And the inducible miR-155 feedback promotes type I IFN signaling, thus suppressing viral replication...
- Systematic review of the literature on assessment, feedback and physicians' clinical performance: BEME Guide No. 7Jon Veloski
Center for Research in Medical Education and Health Care, Jefferson Medical College, Thomas Jefferson University, Philadelphia 19107, USA
Med Teach 28:117-28. 2006There is a basis for the assumption that feedback can be used to enhance physicians' performance. Nevertheless, the findings of empirical studies of the impact of feedback on clinical performance have been equivocal.
- The impact of feedback semantics in visual word recognition: number-of-features effects in lexical decision and naming tasksPenny M Pexman
Department of Psychology, University of Calgary, Alberta, Canada
Psychon Bull Rev 9:542-9. 2002The notion of feedback activation from semantics to both orthography and phonology has recently been used to explain a number of semantic effects in visual word recognition, including polysemy effects (Hino & Lupker, 1996; Pexman &..
- How emotion shapes behavior: feedback, anticipation, and reflection, rather than direct causationRoy F Baumeister
Florida State University, Florida, USA
Pers Soc Psychol Rev 11:167-203. 2007..Instead, the authors develop a theory of emotion as a feedback system whose influence on behavior is typically indirect...
- A systematic review of selected interventions for worksite health promotion. The assessment of health risks with feedbackRobin E Soler
National Center for Health Marketing, CDC, Atlanta, Georgia 30333, USA
Am J Prev Med 38:S237-62. 2010..report provides recommendations on the effectiveness of interventions that use an Assessment of Health Risks with Feedback (AHRF) when used alone or as part of a broader worksite health promotion program to improve the health of ..
- Feedback and reward processing in high-functioning autismMichael J Larson
Department of Psychology, Brigham Young University, Provo, UT 84602, USA
Psychiatry Res 187:198-203. 2011..Such deficits may be influenced by poor ability to process feedback and rewards...
- Redundant pathways for negative feedback regulation of bile acid productionLi Wang
Department of Molecular and Cellular Biology, Houston, TX 77030, USA
Dev Cell 2:721-31. 2002The orphan nuclear hormone receptor SHP has been proposed to have a key role in the negative feedback regulation of bile acid production...
- Brief intervention for heavy-drinking college students: 4-year follow-up and natural historyJ S Baer
Center of Excellence in Substance Abuse Treatment and Education, VA Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA
Am J Public Health 91:1310-6. 2001..This study examined long-term response to an individual preventive intervention for high-risk college drinkers relative to the natural history of college drinking...
- IFN induces miR-21 through a signal transducer and activator of transcription 3-dependent pathway as a suppressive negative feedback on IFN-induced apoptosisChuan He Yang
Departments of Pathology and Laboratory Medicine and Physiology and Center for Integrative Cancer Research, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Cancer Res 70:8108-16. 2010..Our results identify miR-21 as a novel IFN target gene that functions as a key feedback regulator of IFN-induced apoptosis.
- Competition between feedback loops underlies normal and pathological dynamics in the basal gangliaArthur Leblois
Laboratoire de Neurophysique et Physiologie du Système Moteur, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 8119, Universite Rene Descartes, 75270 Paris, France
J Neurosci 26:3567-83. 2006..the subthalamic nucleus, the internal pallidum (GPi), the thalamus, and the cortex are involved in closed feedback loops...
- Control of Dpp morphogen signalling by a secreted feedback regulatorRobin Vuilleumier
Institute for Biology I, Albert Ludwigs University of Freiburg, Hauptstrasse 1, D 79104 Freiburg, Germany
Nat Cell Biol 12:611-7. 2010..We show that Pent interacts with the glypican Dally to control Dpp distribution and provide evidence that proper establishment of the BMP morphogen gradient requires the inbuilt feedback loop embodied by Pent.
- Effects of correct and transformed visual feedback on rhythmic visuo-motor tracking: tracking performance and visual search behaviorM Roerdink
Institute for Fundamental and Clinical Human Movement Sciences, Faculty of Human Movement Sciences, Vrije Universiteit, 1081BT Amsterdam, The Netherlands
Hum Mov Sci 24:379-402. 2005The effects of correct and transformed visual feedback on rhythmic unimanual visuo-motor tracking were examined, focusing on tracking performance (accuracy and stability) and visual search behavior...
- Feedback control of the protein kinase TAK1 by SAPK2a/p38alphaPeter C F Cheung
MRC Protein Phosphorylation Unit, School of Life Sciences, MSI WTB complex, Dow Street, University of Dundee, Dundee DD1 5EH, UK
EMBO J 22:5793-805. 2003..Our results suggest that TAB1 participates in a SAPK2a/p38alpha-mediated feedback control of TAK1, which not only limits the activation of SAPK2a/p38alpha but synchronizes its activity with other ..
- User testing and stakeholder feedback contributed to the development of understandable and useful Summary of Findings tables for Cochrane reviewsSarah E Rosenbaum
Norwegian Knowledge Centre for the Health Services, St Olavs Plass, Oslo, Norway
J Clin Epidemiol 63:607-19. 2010..To develop a Summary of Findings (SoF) table for use in Cochrane reviews that is understandable and useful for health professionals, acceptable to Cochrane Collaboration stakeholders, and feasible to implement...
- The development of computer-generated tailored interventionsA Dijkstra
Department of Clinical and Health Psychology, Leiden University, P O Box 9555, 2300 RB, Leiden, Netherlands
Patient Educ Couns 36:193-203. 1999..This methodology may result in largely different tailored interventions depending on the theoretical framework used, the adaptation of the messages and the inclusion of feedback.
- Axon sprouting in a model of temporal lobe epilepsy creates a predominantly excitatory feedback circuitPaul S Buckmaster
Department of Comparative Medicine, Stanford University School of Medicine, Stanford, California 94305 5330, USA
J Neurosci 22:6650-8. 2002..Rather, it replaces a distally distributed and disynaptic excitatory feedback circuit with one that is local and monosynaptic.
- Neural mechanisms underlying auditory feedback control of speechJason A Tourville
Department of Cognitive and Neural Systems, Boston University, 677 Beacon St, Boston, MA 02215, USA
Neuroimage 39:1429-43. 2008The neural substrates underlying auditory feedback control of speech were investigated using a combination of functional magnetic resonance imaging (fMRI) and computational modeling...
- Neural correlates of verbal feedback processing: an fMRI study employing overt speechIngrid K Christoffels
Department of Cognitive Neuroscience, Faculty of Psychology, Maastricht University, The Netherlands
Hum Brain Mapp 28:868-79. 2007Speakers use external auditory feedback to monitor their own speech. Feedback distortion has been found to increase activity in the superior temporal areas...
- What is feedback in clinical education?J M Monica van de Ridder
Centre for Research and Development, University Medical Centre Utrecht, Utrecht, The Netherlands
Med Educ 42:189-97. 2008b>Feedback is important in clinical education. However, the medical education literature provides no consensual definition of feedback...
- Brain states: top-down influences in sensory processingCharles D Gilbert
The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Neuron 54:677-96. 2007..are determined by the interactions between multiple cortical areas and the modulation of intrinsic circuits by feedback connections...
- Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolinE Carballo
Office of Clinical Research and Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
Science 281:1001-5. 1998..These findings identify TTP as a component of a negative feedback loop that interferes with TNF-alpha production by destabilizing its messenger RNA...
- p21(WAF1) is component of a positive feedback loop that maintains the p53 transcriptional programLisa Y Pang
CRUK Cell Signalling Unit, Institute of Genetics and Molecular Medicine, Edinburgh, Scotland, UK
Cell Cycle 10:932-50. 2011The regulation of p53 activity through the MDM2 negative feedback loop is driven in part by an extrinsic ATM-pulse that maintains p53 oscillations in response to DNA damage...
- Self-esteem modulates medial prefrontal cortical responses to evaluative social feedbackLeah H Somerville
Department of Psychological and Brain Sciences, Center for Cognitive Neuroscience, Dartmouth College, Hanover, NH 03755, USA
Cereb Cortex 20:3005-13. 2010..As such, self-esteem may bias neural responses to positive and negative social feedback across individuals...
- It was not MY fault: event-related brain potentials in active and observational learning from feedbackChristian Bellebaum
Institute of Cognitive Neuroscience, Department of Neuropsychology, Ruhr University of Bochum, Universitaetsstraße 150, Bochum, Germany
Cereb Cortex 20:2874-83. 2010Performance feedback during learning is accompanied by a negative event-related potentials (ERP) component, the feedback-related negativity (FRN), which codes a reward prediction error...
- Learning-induced enhancement of feedback inhibitory synaptic transmissionInbar Brosh
Departments of Neurobiology and Biology, Faculty of Sciences, University of Haifa 31905, Israel
Learn Mem 16:413-6. 2009..We suggest that learning is accompanied by long-lasting enhancement of synaptic inhibition onto excitatory neurons, thus compensating for the increase of excitation in these neurons...
- Vocalization-induced enhancement of the auditory cortex responsiveness during voice F0 feedback perturbationRoozbeh Behroozmand
Speech Physiology Laboratory, Department of Communication Science and Disorders, Northwestern University, 2240 Campus Drive, Evanston, IL 60208, USA
Clin Neurophysiol 120:1303-12. 2009The present study investigated whether self-vocalization enhances auditory neural responsiveness to voice pitch feedback perturbation and how this vocalization-induced neural modulation can be affected by the extent of the feedback ..
- Multiple parietal reach regions in humans: cortical representations for visual and proprioceptive feedback during on-line reachingFlavia Filimon
Department of Cognitive Science, University of California, San Diego, La Jolla, California 92093, USA
J Neurosci 29:2961-71. 2009Reaching toward a visual target involves at least two sources of information. One is the visual feedback from the hand as it approaches the target...
- Frequency control of motor patterning by negative sensory feedbackJessica Ausborn
Institute of Neurobiology, Ulm University, D 89069 Ulm, Germany
J Neurosci 27:9319-28. 2007..key role in the generation of behavior by providing the nervous system with information about the environment and feedback about body movements such that motor output can continuously be adapted to changing circumstances...
- The effects of spike frequency adaptation and negative feedback on the synchronization of neural oscillatorsB Ermentrout
Department of Mathematics, University of Pittsburgh, Pittsburgh, PA 15260, USA
Neural Comput 13:1285-310. 2001..The shunting behavior is captured in a simple two-variable reduced model that arises near certain types of bifurcations. A one-dimensional map is derived from the simplified model...
- Enhanced negative feedback responses in remitted depressionDiane L Santesso
Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
Neuroreport 19:1045-8. 2008Major depressive disorder (MDD) is characterized by hypersensitivity to negative feedback that might involve frontocingulate dysfunction...
- Feedforward, horizontal, and feedback processing in the visual cortexV A Lamme
Graduate School of Neurosciences, Department of Medical Physics, University of Amsterdam, The Netherlands
Curr Opin Neurobiol 8:529-35. 1998..These modulations reflect lateral interactions within areas and feedback from higher to lower areas...
- Dependence of stem cell fate in Arabidopsis on a feedback loop regulated by CLV3 activityU Brand
Institut fur Entwicklungsbiologie, Universitat zu Koln, Gyrhofstrabetae 17, D 50923 Köln, Germany
Science 289:617-9. 2000..fate of stem cells in plant meristems is governed by directional signaling systems that are regulated by negative feedback. In Arabidopsis thaliana, the CLAVATA (CLV) genes encode the essential components of a negative, stem cell-..
- Neural correlates of auditory feedback control in humanA Toyomura
Research Institute of Science and Technology for Society, Japan Science and Technology Agency, Japan
Neuroscience 146:499-503. 2007Auditory feedback plays an important role in natural speech production...
- CPR quality improvement during in-hospital cardiac arrest using a real-time audiovisual feedback systemBenjamin S Abella
Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Resuscitation 73:54-61. 2007..We hypothesized that real-time feedback during CPR would improve the performance of chest compressions and ventilations during in-hospital cardiac arrest.
- Self-controlled feedback is effective if it is based on the learner's performanceSuzete Chiviacowsky
School of Physical Education, Federal University of Pelotas, Brazil
Res Q Exerc Sport 76:42-8. 2005The study follows up on the contention that self-controlled feedback schedules benefit learning because they are more tailored to the performers' needs than externally controlled feedback schedules (Chiviacowsky & Wulf, 2002)...
- Dorsal anterior cingulate cortex shows fMRI response to internal and external error signalsClay B Holroyd
Department of Psychology, Green Hall, Princeton University, Princeton, New Jersey 08544, USA
Nat Neurosci 7:497-8. 2004..imaging (fMRI) experiment, participants learned to select between two response options by trial-and-error, using feedback stimuli that indicated monetary gains and losses...
- Long-distance feedback projections to area V1: implications for multisensory integration, spatial awareness, and visual consciousnessSimon Clavagnier
INSERM U371, IFR19 corrected Université Claude Bernard Lyon 1, Bron, France
Cogn Affect Behav Neurosci 4:117-26. 2004..We have, therefore, reexamined feedback projections to area V1, using retrograde tracer injections in this area In addition to well-known areas, ..
- Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lungPao Tien Chuang
Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
Genes Dev 17:342-7. 2003..Our studies focused on Hip1 in the lung. Here, a dynamic interaction between Hh and fibroblast growth factor (Fgf) signaling, modulated at least in part by Hip1, controls early lung branching...
- Adaptation to visual feedback delays in manual tracking: evidence against the Smith Predictor model of human visually guided actionR C Miall
Behavioural Brain Sciences, School of Psychology, University of Birmingham, B15 2TT Birmingham, UK
Exp Brain Res 172:77-84. 2006We report adaptation to delayed visual feedback during a manual tracking task, testing the nature of the adapted responses with frequency analysis...
- Postural feedback responses scale with biomechanical constraints in human standingSukyung Park
Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI 48109 2125, USA
Exp Brain Res 154:417-27. 2004We tested whether human postural responses can be described in terms of feedback control gains, and whether these gains are scaled by the central nervous system to accommodate biomechanical constraints...
- Positive feedback and noise activate the stringent response regulator rel in mycobacteriaKamakshi Sureka
Department of Chemistry, Bose Institute, Kolkata, India
PLoS ONE 3:e1771. 2008..two distinct peaks corresponding to low (L) and high (H) expression states, and further establish that a positive feedback loop involving the mprAB operon along with stochastic gene expression are responsible for the phenotypic ..
- Individual-level interventions to reduce college student drinking: a meta-analytic reviewKate B Carey
Center for Health and Behavior, Syracuse University, Syracuse, NY 13244 2340, USA
Addict Behav 32:2469-94. 2007..suggest that individual, face-to-face interventions using motivational interviewing and personalized normative feedback predict greater reductions in alcohol-related problems...
- Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brainAiwu Cheng
Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
Dev Biol 258:319-33. 2003....
- Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesisThomas A Kerr
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75390, USA
Dev Cell 2:713-20. 2002The in vivo role of the nuclear receptor SHP in feedback regulation of bile acid synthesis was examined...
- Spatio-temporal prediction modulates the perception of self-produced stimuliS J Blakemore
Wellcome Department of Cognitive Neurology, University College London, 12 Queen Square, London WC1N 3BG, UK
J Cogn Neurosci 11:551-9. 1999..e., its tickliness) is proportional to the error between the sensory feedback predicted by an internal forward model of the motor system and the actual sensory feedback produced by the ..
- A c-Myc-SIRT1 feedback loop regulates cell growth and transformationJian Yuan
Division of Oncology Research, Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA
J Cell Biol 185:203-11. 2009..Overall, our experiments identify a c-Myc-SIRT1 feedback loop in the regulation of c-Myc activity and cellular transformation, supporting/suggesting a role of SIRT1 in ..
- Error and feedback processing in children with ADHD and children with Autistic Spectrum Disorder: an EEG event-related potential studyYvonne Groen
Department of Psychiatry, University Medical Center Groningen, University of Groningen, P O Box 660, 9700 AR Groningen, The Netherlands
Clin Neurophysiol 119:2476-93. 2008....
- Training with virtual visual feedback to alleviate phantom limb painCatherine Mercier
Center for Cognitive Neuroscience, Bron, France
Neurorehabil Neural Repair 23:587-94. 2009Performing phantom movements with visual virtual feedback, or mirror therapy, is a promising treatment avenue to alleviate phantom limb pain. However the effectiveness of this approach appears to vary from one patient to another.
- PTH increases FGF23 gene expression and mediates the high-FGF23 levels of experimental kidney failure: a bone parathyroid feedback loopVardit Lavi-Moshayoff
Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew Univ Medical Center, PO Box 12000, Jerusalem, Israel 91120
Am J Physiol Renal Physiol 299:F882-9. 2010..The effect of PTH on FGF23 completes a bone-parathyroid endocrine feedback loop. Importantly, secondary hyperparathyroidism is essential for the high-FGF23 levels in early CKD.
- Real-time contributions of auditory feedback to avian vocal motor controlJon T Sakata
Keck Center for Integrative Neuroscience, Department of Physiology, University of California, San Francisco, San Francisco, California 94143 0444, USA
J Neurosci 26:9619-28. 2006..Evidence strongly indicates that auditory feedback contributes in real time to human speech, but similar contributions of feedback to birdsong remain unclear...
- An fMRI study of verbal self-monitoring: neural correlates of auditory verbal feedbackCynthia H Y Fu
Institute of Psychiatry, King s College London, De Crespigny Park, London SE5 8AF, UK
Cereb Cortex 16:969-77. 2006..According to the model, if the expected verbal feedback matches the perceived feedback, then there would be no change in activation in the lateral temporal cortices...
- Evidence for the flexible sensorimotor strategies predicted by optimal feedback controlDan Liu
Department of Cognitive Science, University of California, San Diego, La Jolla, California 92093 0515, USA
J Neurosci 27:9354-68. 2007..relationship between the task and the strategy most suitable for accomplishing it lies at the core of our optimal feedback control theory of coordination...
- Cortical factor feedback model for cellular locomotion and cytofissionShin I Nishimura
Department of Computational Science and Engineering, Nagoya University, Nagoya, Japan
PLoS Comput Biol 5:e1000310. 2009..In this paper, we propose a hypothesis that the positive feedback mechanism working through the inhomogeneous distribution of regulatory proteins underlies this variety of cell ..
- Receiving a summary of the results of a trial: qualitative study of participants' viewsMary Dixon-Woods
Social Science Group, Department of Health Sciences, University of Leicester, Leicester LE1 6TP
BMJ 332:206-10. 2006..To explore trial participants' responses to receiving a summary of the results of a trial in pregnancy...
- Thyroid hormone exerts negative feedback on hypothalamic type 4 melanocortin receptor expressionStéphanie Decherf
Departement Regulations, Centre National de la Recherche Scientifique Unité Mixte de Recherche 7221, Evolution des Regulations Endocriniennes, Museum national d histoire naturelle, Paris, France
Proc Natl Acad Sci U S A 107:4471-6. 2010..These facts led us to test the hypothesis that energy homeostasis should require negative feedback by T(3) on Mc4r expression...
- Computational motor control: feedback and accuracyEmmanuel Guigon
INSERM U742, ANIM, Université Pierre et Marie Curie UPMC Paris 6, 9, quai Saint Bernard, 75005 Paris, France
Eur J Neurosci 27:1003-16. 2008..in which motor variability results from the interplay between sensory and motor execution noises in an optimal feedback-controlled system...
- Interconnected feedback loops in the Neurospora circadian systemK Lee
Department of Genetics, Dartmouth Medical School, Hanover, NH 03755 3844, USA
Science 289:107-10. 2000..FRQ thus plays dual roles in the Neurospora clock and thereby, with WC-1, forms a second feedback loop that would promote robustness and stability in this circadian system...
- Feedforward and feedback inhibition in neostriatal GABAergic spiny neuronsJames M Tepper
Center for Molecular and Behavioral Neuroscience, Rutgers University, 197 University Avenue, Newark, NJ 07102, USA
Brain Res Rev 58:272-81. 2008..The feedback circuit comprises the numerous spiny projection neurons and their interconnections via local axon collaterals...
- Stretch-induced changes in heart rate and rhythm: clinical observations, experiments and mathematical modelsP Kohl
University Laboratory of Physiology, Oxford, UK
Prog Biophys Mol Biol 71:91-138. 1999..direction of the cross-talk between cardiac electrical and mechanical activity is referred to as mechano-electric feedback (MEF)...
- A sensory feedback circuit coordinates muscle activity in DrosophilaCynthia L Hughes
Molecular Neurobiology Laboratory, The Salk Institute, 10010 N Torrey Pines Rd, La Jolla, CA 92037, USA
Mol Cell Neurosci 35:383-96. 2007..The bipolar dendrites and class I mds send a feedback signal to the CNS that keeps the contraction wave progressing quickly, allowing smooth forward movement...
- Direct neural sensory feedback and control of a prosthetic armGurpreet Singh Dhillon
Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX 77030, USA
IEEE Trans Neural Syst Rehabil Eng 13:468-72. 2005..We believe this to be the first demonstration of direct neural feedback from and direct neural control of an artificial arm in amputees.
- Hes6 acts in a positive feedback loop with the neurogenins to promote neuronal differentiationN Koyano-Nakagawa
The Salk Institute for Biological Studies, PO Box 85800, La Jolla, CA 92186 5800, USA
Development 127:4203-16. 2000..The properties of Hes6 distinguish it from other members of the WRPW-bHLH family in vertebrates, and suggest that it acts in a positive-feedback loop with the proneural bHLH proteins to promote neuronal differentiation.
- Noise propagation and signaling sensitivity in biological networks: a role for positive feedbackGil Hornung
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
PLoS Comput Biol 4:e8. 2008..Negative feedback can buffer this type of noise, but this buffering comes at the expense of an even greater reduction in signaling ..
- Modular cell biology: retroactivity and insulationDomitilla Del Vecchio
Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, MI 48109, USA
Mol Syst Biol 4:161. 2008..To attenuate the effect of retroactivity, we propose a feedback mechanism inspired by the design of amplifiers in electronics...
- Compensatory responses to loudness-shifted voice feedback during production of Mandarin speechHanjun Liu
Department of Communication Sciences and Disorders, Northwestern University, 2240 Campus Drive, Evanston, Illinois 60208, USA
J Acoust Soc Am 122:2405-12. 2007Previous studies have demonstrated that perturbations in voice pitch or loudness feedback lead to compensatory changes in voice F(0) or amplitude during production of sustained vowels...
- HD-ZIP III activity is modulated by competitive inhibitors via a feedback loop in Arabidopsis shoot apical meristem developmentYoun Sung Kim
Department of Chemistry, Seoul National University, Seoul 151 742, Korea
Plant Cell 20:920-33. 2008..We therefore propose that HD-ZIP III activity in regulating SAM development is modulated by, among other things, a feedback loop involving the competitive inhibitors ZPR3 and ZPR4.
- Feedback signals from cat's area 21a enhance orientation selectivity of area 17 neuronsC Wang
Discipline of Anatomy and Histology, School of Medical Sciences and Bosch Institute F13, The University of Sydney, Sydney, NSW 2006, Australia
Exp Brain Res 182:479-90. 2007We have studied the contribution of feedback signals originating from one of the "form-processing" extrastriate cortical areas, area 21a (A21a), to orientation selectivity of single neurons in the ipsilateral area 17 (A17)...
- Development of intraoperative electrochemical detection: wireless instantaneous neurochemical concentration sensor for deep brain stimulation feedbackJamie J Van Gompel
Department of Neurological Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
Neurosurg Focus 29:E6. 2010..on a second-to-second time scale or for chronically used implanted recordings, as would be required for DBS feedback. Electrochemical detection techniques such as fast-scan cyclic voltammetry (FSCV) and amperometry have until ..
- Clinical teaching improves with resident evaluation and feedbackKeith Baker
Harvard Medical School, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Anesthesiology 113:693-703. 2010The literature is mixed on whether evaluation and feedback to clinical teachers improves clinical teaching...
- A randomized clinical trial of clinician feedback to improve quality of care for inner-city children with asthmaMeyer Kattan
Department of Pediatrics, Mount Sinai School of Medicine, New York, NY 10029, USA
Pediatrics 117:e1095-103. 2006..Barriers impede translating recommendations for asthma treatment into practice, particularly in inner cities where asthma morbidity is highest...
- Representation of internal models of action in the autistic brainCourtney C Haswell
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Nat Neurosci 12:970-2. 2009..autistic brain built a stronger than normal association between self-generated motor commands and proprioceptive feedback; furthermore, the greater the reliance on proprioception, the greater the child's impairments in social function ..
- A randomized trial of computer-based reminders and audit and feedback to improve HIV screening in a primary care settingV Sundaram
VA Palo Alto Healthcare System, Palo Alto, CA, USA
Int J STD AIDS 20:527-33. 2009..The objective of the study was to determine whether an intervention with computer-based reminders and feedback would increase screening for HIV in a Department of Veterans Affairs (VA) health-care system...
- Internalizing agency of self-action: perception of one's own hand movements depends on an adaptable prediction about the sensory action outcomeMatthis Synofzik
Department of Cognitive Neurology, Hertie Institute of Clinical Brain Research, University of Tubingen, Tubingen, Germany
J Neurophysiol 96:1592-601. 2006..Twenty human subjects performed out-and-back pointing movements that were fed back visually. Feedback was initially presented in spatiotemporal correspondence with respect to the actual finger position, but later ..
- Enabling multi-level relevance feedback on PubMed by integrating rank learning into DBMSHwanjo Yu
CSE Department, POSTECH, Pohang, South Korea
BMC Bioinformatics 11:S6. 2010..This paper proposes a novel multi-level relevance feedback system for PubMed, called RefMed, which supports both ad-hoc keyword queries and a multi-level relevance feedback ..
- Neural correlates of developmental differences in risk estimation and feedback processingLinda van Leijenhorst
Center for Mind and Brain, University of California at Davis, USA
Neuropsychologia 44:2158-70. 2006..The task was designed to tap two important aspects of decision-making: risk estimation and feedback processing...
- Estimating the sources of motor errors for adaptation and generalizationMax Berniker
Rehabilitation Institute of Chicago, Department of Physical Medicine and Rehabilitation, Northwestern University, 345 E Superior Street, ONT 931, Chicago, Illinois 60611, USA
Nat Neurosci 11:1454-61. 2008..We provide evidence that many movement-generalization phenomena emerge from a strategy by which the nervous system estimates the sources of our motor errors...
- How much feedback is necessary for learning to suture?A O'Connor
Department of Mechanical Engineering, Tufts University, 200 College Avenue, Medford, Massachusetts 02155, USA
Surg Endosc 22:1614-9. 2008..In addition, the overall workload of a trainee during training would decrease as skills improved, especially when KR and coaching were provided...
- Adaptive control of saccades via internal feedbackHaiyin Chen-Harris
Departments of Biomedical Engineering and Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
J Neurosci 28:2804-13. 2008Ballistic movements like saccades require the brain to generate motor commands without the benefit of sensory feedback. Despite this, saccades are remarkably accurate...
- Human midbrain sensitivity to cognitive feedback and uncertainty during classification learningA R Aron
Dept of Psychology and Brain Research Institute, University of California Los Angeles, CA 90065, USA
J Neurophysiol 92:1144-52. 2004..classification learning in humans using functional magnetic resonance imaging to examine the effects of feedback and uncertainty...
- Effects of visual force feedback on robot-assisted surgical task performanceCarol E Reiley
Engineering Research Center and Computer Integrated Surgery Systems and Technology, Johns Hopkins University, Baltimore, MD, USA
J Thorac Cardiovasc Surg 135:196-202. 2008Direct haptic (force or tactile) feedback is negligible in current surgical robotic systems. The relevance of haptic feedback in robot-assisted performances of surgical tasks is controversial...
Research Grants194 found, 100 shown here
- Mechanistic bases for age-related androgen deficiencyJohannes Veldhuis; Fiscal Year: 2007..HYPOTHESIS III: Reduced negative feedback by testosterone, which unleashes high-frequency, low- amplitude and irregular LH release...
- Ensemble Disruption of the GnRH-LH-Testosterone AxisJohannes Veldhuis; Fiscal Year: 2007..Interpreted from this vantage, published literature, laboratory experiments, background data and ensemble feedback/feed forward simulations predict that hydroandrogenemia in aging men could arise nonexclusively by way of: (i) ..
- Ensemble Control of ACTH Secretion: Impact of GenderJohannes Veldhuis; Fiscal Year: 2007..receptor (ER and AR); (2) graded " imposition of delayed (integral) and rapid (rate-sensitive) cortisol negative feedback during adrenal steroidogenic blockade; (3) joint dose-dependent stimulation of ACTH secretion by human CRH and ..
- Age-Dependent Estrogen-Independent Mechanism of Hyposomatotropism in WomenJohannes Veldhuis; Fiscal Year: 2007..Hypothesis III: Age and E2 availability jointly modulate concentration-dependent negative feedback by free (protein-unbound) IGF-I, thus controlling mean daily GH secretion...
- Analytical Reconstruction of Feedback Signaling in Aging MenJohannes Veldhuis; Fiscal Year: 2007Self-adaptive (homeostatic) biological systems operate via repeated incremental feedback and feed forward signaling adjustments to maintain species, gender and age-defined physiological norms...
- ACTIONS OF ESTROGEN IN MATURING GRAAFIAN FOLLICLESJohannes Veldhuis; Fiscal Year: 2001....
- Novel Active Repressor Model of Human LDL-Receptor RegulationJohannes Veldhuis; Fiscal Year: 2007..If so, targeting this gene product could potentially shift cholesterol accumulation away from arteries toward the liver. This would represent a new treatment approach for patients with atherosclerotic disease. ..
- THE AGING GH AXIS IN POSTMENOPAUSAL WOMENJohannes Veldhuis; Fiscal Year: 2005..Hypothesis III: Estrogen add back can override GH's autonegative feedback restraint of GH secretion...
- ACTIONS OF ESTROGEN IN MATURING GRAAFIAN FOLLICLESJohannes Veldhuis; Fiscal Year: 2005..Understanding such fundamental interactions is important to the rational design of alternative strategies to interrupt normal and rescue impaired steroidogenesis in the maturing Graafian follicle and corpus luteum. ..
- ENSEMBLE MODEL OF STRESS ACTH-ADRENAL AXISJohannes Veldhuis; Fiscal Year: 2005..sheep, horse and human, the stress-responsive corticotropic-adrenal axis can be viewed as a dynamically adaptive feedback system supervised by key brain (hypothalamic) regulatory centers...
- ACTIONS OF TESTOSTERONE ON THE AGING MALE GH AXISJohannes Veldhuis; Fiscal Year: 2007..suppress GH secretory-burst mass in part by: (i) elevating somatostatin (SS) outflow under high (nighttime) GH feedback; and (ii) augmenting SSergic restraint under low (daytime) GH feedback...
- AGING GH AXIS IN POSTMENOPAUSAL WOMENJohannes Veldhuis; Fiscal Year: 2000..3. Estrogen replacement in postmenopausal women curtails inhibitory auto- feedback of the hypothalamo-pituitary GH unit otherwise exerted by IGF-I and/or GH...
- Age-Dependent Estrogen-Independent Mechanism of Hyposomatotropism in WomenJohannes Veldhuis; Fiscal Year: 2009..Hypothesis III: Age and E2 availability jointly modulate concentration-dependent negative feedback by free (protein-unbound) IGF-I, thus controlling mean daily GH secretion...
- Ensemble Control of ACTH Secretion: Impact of GenderJohannes D Veldhuis; Fiscal Year: 2010..receptor (ER and AR);(2) graded " imposition of delayed (integral) and rapid (rate-sensitive) cortisol negative feedback during adrenal steroidogenic blockade;(3) joint dose-dependent stimulation of ACTH secretion by human CRH and AVP;..
- Age-Dependent Estrogen-Independent Mechanism of Hyposomatotropism in WomenJohannes D Veldhuis; Fiscal Year: 2010..Hypothesis III: Age and E2 availability jointly modulate concentration-dependent negative feedback by free (protein-unbound) IGF-I, thus controlling mean daily GH secretion...
- Aging Systems in Geriatrics: the Male Gonadal AxisJohannes D Veldhuis; Fiscal Year: 2010..pituitary luteinizing hormone (LH) secretion;(ii) impaired Leydig-cell responsiveness to LH pulses;and reduced feedback by Te onto GnRH and LH secretion...
- Ensemble Control of ACTH Secretion: Impact of GenderJohannes Veldhuis; Fiscal Year: 2009..receptor (ER and AR); (2) graded " imposition of delayed (integral) and rapid (rate-sensitive) cortisol negative feedback during adrenal steroidogenic blockade; (3) joint dose-dependent stimulation of ACTH secretion by human CRH and ..
- ACTIONS OF ESTROGEN IN MATURING GRAAFIAN FOLLICLESJohannes Veldhuis; Fiscal Year: 1990..Accordingly, these investigations are likely to contribute to new approaches to fertility regulation in the human, domestic animal or endangered wild species...
- ACTIONS OF ESTROGEN IN MATURING GRAAFIAN FOLLICLESJohannes Veldhuis; Fiscal Year: 1993..The preceding studies should contribute important new insights into and further developments in fertility regulation in man, domestic animals, and endangered wild species...
- Ultra-brief intervention for problem drinkersJohn A Cunningham; Fiscal Year: 2010..The major objective of this proposal is to conduct a randomized controlled trial of an ultra-brief, personalized feedback intervention for problem drinkers...
- Internet-based intervention for problem drinkingJohn Cunningham; Fiscal Year: 2007..be randomly assigned to be sent a world wide web page internet address and password for the personalized alcohol feedback program or to a no intervention control group...
- Motion Sensor Array for Vestibular-deficient IndividualsConrad Wall; Fiscal Year: 2005....
- Tests of neurobiologically-inspired Model of the Motivation-Learning InterfaceW TODD TODD MADDOX; Fiscal Year: 2010..This proposal reunites research on motivation and cognition to better understanding their effects on functioning in clinical populations. ..
- Neural substrates for contextual integrationAlessandra Angelucci; Fiscal Year: 2004..goal of this proposal is to disentangle the relative contributions of long-range inter-areal (feedforward and feedback) and intra-areal (horizontal) corticocortical connections to these global-to-local computations in early visual ..
- Combined Treatment for GADPaul Crits Christoph; Fiscal Year: 2007..Data analysis will focus on differential rate of change (mixed model analyses) for the two groups. If promising results are obtained for combined treatment, a larger more definitive trial will be planned. ..
- Event Specific PreventionClayton Neighbors; Fiscal Year: 2007..Brief motivational interventions utilizing personalized feedback have consistently demonstrated reductions in the average number of drinks students consume over time...
- A Spiking Model of Hippocampus for Guiding BehaviorMichael Hasselmo; Fiscal Year: 2006..U., which focuses on modeling operant tasks used in experimental studies of drug self-administration phenomena, in work supported by a supplement to a previous grant from NIDA. ..
- Female Anti-Problem Drinking Group & Campus InitiativesJoseph LaBrie; Fiscal Year: 2006..Campus awareness will increase and campus culture will be changed. Evaluation/analysis plan is included. ..
- NEUROMODULATION AND CORTICAL MEMORY FUNCTIONMichael Hasselmo; Fiscal Year: 2009..I-m), and testing time course of mGluR modulation of transmission in s. I-m. Understanding these mechanisms may assist in development of pharmacological treatments for Alzheimer's disease. ..
- Neural substrates for contextual integrationAlessandra Angelucci; Fiscal Year: 2007..The long-term goal of this proposal is to disentangle the relative contributions of inter-areal (feedforward and feedback) and intra-areal horizontal corticocortical connections to these global-to-local interactions in early visual ..
- Parallel pathways in visual cortex: functional connectivity of output pathways frAlessandra Angelucci; Fiscal Year: 2010....
- Sensory Mechanisms of Voice ControlCharles R Larson; Fiscal Year: 2010..Recent research has shown that sensory feedback plays an important role in voice control...
- CHOLINERGIC REGULATION OF ENTORHINAL NETWORK FUNCTIONMichael Hasselmo; Fiscal Year: 2004..Hypothesis number 2. Low acetylcholine levels in entorhinal cortex and hippocampus allows strong feedback appropriate for forming additional memory traces...
- AUTOREGULATION OF GLOMERULAR FILTRATION RATERoland Blantz; Fiscal Year: 2000..of glomerular tubular balance (GTB) which is the flow dependence of tubular reabsorption, and tubuloglomerular feedback (TGF), which is the negative feedback regulation of nephron filtration rate (SNGFR) by late proximal tubular flow ..
- NEUROMODULATION AND CORTICAL MEMORY FUNCTIONMichael Hasselmo; Fiscal Year: 2007..I-m), and testing time course of mGluR modulation of transmission in s. I-m. Understanding these mechanisms may assist in development of pharmacological treatments for Alzheimer's disease. ..
- Sensory Mechanisms of Voice ControlCharles Larson; Fiscal Year: 2007..It is assumed that sensory feedback may be involved in control of the voice, but there is little hard evidence to support this claim...