lymphocyte cooperation


Summary: T-cell enhancement of the B-cell response to thymic-dependent antigens.

Top Publications

  1. Poholek A, Hansen K, Hernandez S, Eto D, Chandele A, Weinstein J, et al. In vivo regulation of Bcl6 and T follicular helper cell development. J Immunol. 2010;185:313-26 pubmed publisher
    ..These data increase our understanding of Bcl6 regulation in T(FH) cells and their differentiation in vivo and identifies a new surface marker that may be functionally relevant in this subset...
  2. Vogelzang A, McGuire H, Yu D, Sprent J, Mackay C, King C. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity. 2008;29:127-37 pubmed publisher
    ..This study reveals a previously unappreciated role for Tfh cells in the formation of the GC and isotype switching through a CD4(+) T cell-intrinsic requirement for IL-21. ..
  3. Krawczyk C, Oliveira dos Santos A, Sasaki T, Griffiths E, Ohashi P, Snapper S, et al. Vav1 controls integrin clustering and MHC/peptide-specific cell adhesion to antigen-presenting cells. Immunity. 2002;16:331-43 pubmed
    ..Our data reveal a novel role for Vav1 and WASP in the regulation of TCR-induced integrin clustering and cell adhesion and show that integrin and TCR clustering are controlled by distinct pathways. ..
  4. Kim C, Rott L, Clark Lewis I, Campbell D, Wu L, Butcher E. Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells. J Exp Med. 2001;193:1373-81 pubmed
    ..Our results demonstrate that CXCR5+ T cells are functionally heterogeneous and that the GC-Th cells, a small subset of CXCR5+ T cells, are the key helpers for B cell differentiation and antibody production in lymphoid tissues. ..
  5. Cella M, Scheidegger D, Palmer Lehmann K, Lane P, Lanzavecchia A, Alber G. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J Exp Med. 1996;184:747-52 pubmed
    ..These findings reveal a new role for CD40-CD40L interaction in regulating DC function and are relevant to design therapeutic strategies using cultured DCs. ..
  6. Bouzahzah F, Bosseloir A, Heinen E, Simar L. Human germinal center CD4+CD57+ T cells act differently on B cells than do classical T-helper cells. Dev Immunol. 1995;4:189-97 pubmed
    ..CD4+CD57- cells, however, enhance B-cell proliferation and differentiation, thus acting like the classical helper cells of the T-dependent areas. ..
  7. Gärdby E, Chen X, Lycke N. Impaired CD40-signalling in CD19-deficient mice selectively affects Th2-dependent isotype switching. Scand J Immunol. 2001;53:13-23 pubmed
    ..Thus, our study in CD19-deficient mice suggests that CD40L-CD40-interactions are more important for Th2 than for Th1 co-ordinated B-cell differentiation. ..
  8. Cobbold S, Jayasuriya A, Nash A, Prospero T, Waldmann H. Therapy with monoclonal antibodies by elimination of T-cell subsets in vivo. Nature. 1984;312:548-51 pubmed
    ..21). We show here that unmodified monoclonal antibodies can be extremely effective at depleting cells in vivo and can be used for the selective manipulation of different aspects of the immune response. ..
  9. Grinberg Bleyer Y, Saadoun D, Baeyens A, Billiard F, Goldstein J, Gregoire S, et al. Pathogenic T cells have a paradoxical protective effect in murine autoimmune diabetes by boosting Tregs. J Clin Invest. 2010;120:4558-68 pubmed publisher
    ..In vivo experiments showed that this Treg boost was partially dependent on TNF but not on IL-2. This feedback regulatory loop between Teffs and Tregs may be critical to preventing or limiting the development of autoimmune diseases. ..

More Information


  1. Miller J. Antigen-specific clone selection in vivo. Immunol Cell Biol. 2008;86:24-5 pubmed
  2. Coyle A, Gutierrez Ramos J. The expanding B7 superfamily: increasing complexity in costimulatory signals regulating T cell function. Nat Immunol. 2001;2:203-9 pubmed
    ..These molecules play an important sequential role and act, together with B7-1- and B7-2-primed T cells, in the acquisition of effector function and/or tolerance induction. ..
  3. Sieling P, Porcelli S, Duong B, Spada F, Bloom B, Diamond B, et al. Human double-negative T cells in systemic lupus erythematosus provide help for IgG and are restricted by CD1c. J Immunol. 2000;165:5338-44 pubmed
    ..The data suggest that CD1c-restricted T cells from SLE patients can provide help to CD1c(+) B cells for IgG production and could therefore promote pathogenic autoantibody responses in SLE. ..
  4. Gulbranson Judge A, Tybulewicz V, Walters A, Toellner K, MacLennan I, Turner M. Defective immunoglobulin class switching in Vav-deficient mice is attributable to compromised T cell help. Eur J Immunol. 1999;29:477-87 pubmed
    ..These results suggest that defective immunoglobulin class switching in Vav-deficient mice is attributable to compromised T cell help. ..
  5. Kibler R, Fritz R, Chou F, Jen Chou C H -, Peacocke N, Brown N, et al. Immune response of Lewis rats to peptide C1 (residues 68-88) of guinea pig and rat myelin basic proteins. J Exp Med. 1977;146:1323-31 pubmed
  6. Vikingsson A, Pederson K, Muller D. Altered kinetics of CD4+ T cell proliferation and interferon-gamma production in the absence of CD8+ T lymphocytes in virus-infected beta2-microglobulin-deficient mice. Cell Immunol. 1996;173:261-8 pubmed
  7. Walker L, Wiggett H, Gaspal F, Raykundalia C, Goodall M, Toellner K, et al. Established T cell-driven germinal center B cell proliferation is independent of CD28 signaling but is tightly regulated through CTLA-4. J Immunol. 2003;170:91-8 pubmed
    ..By examining germinal center responses in mice where the ability to signal through T cell CTLA-4 was compromised, we provide data that supports a critical role for CTLA-4 in down-regulating T cell help for germinal center B cells. ..
  8. Kaliyaperumal A, Michaels M, Datta S. Naturally processed chromatin peptides reveal a major autoepitope that primes pathogenic T and B cells of lupus. J Immunol. 2002;168:2530-7 pubmed
    ..Convergence of T and B cell epitopes in H1'(22-42) and its ability to elicit a cross-reactive response make it a highly dominant epitope that could be targeted for therapy and for tracking autoimmune T and B cells. ..
  9. Haddad E, Le Deist F, Aucouturier P, Cavazzana Calvo M, Blanche S, de Saint Basile G, et al. Long-term chimerism and B-cell function after bone marrow transplantation in patients with severe combined immunodeficiency with B cells: A single-center study of 22 patients. Blood. 1999;94:2923-30 pubmed
    ..These results strongly suggest that, in some transplanted patients, host B cells can cooperate with donor T cells to fully mature in Ig-producing cells. ..
  10. Swallow M, Wallin J, Sha W. B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha. Immunity. 1999;11:423-32 pubmed
    ..These data define a novel costimulatory ligand for T cells and suggest that induction of B7h by TNFalpha may function as a mechanism to directly augment recognition of self during inflammation. ..
  11. Li W. Synergistic antibody induction by antigen-CD40 ligand fusion protein as improved immunogen. Immunology. 2005;115:215-22 pubmed
    ..These results suggest that GFP-CD40LT fusion protein induces a GFP-specific B-cell activation and antibody response in an antigen-guided fashion. The potential application of this novel strategy in vaccine development is discussed. ..
  12. Silvestre R, Cordeiro da Silva A, Tavares J, Sereno D, Ouaissi A. Leishmania cytosolic silent information regulatory protein 2 deacetylase induces murine B-cell differentiation and in vivo production of specific antibodies. Immunology. 2006;119:529-40 pubmed
    ..Together, the current study provides the first evidence that a Leishmania protein belonging to the SIR2 family may play a role in the regulation of immune response through its capacity to trigger B-cell effector function. ..
  13. Yang J, Kim P, Halder R, Singh R. Intrinsic hyporesponsiveness of invariant natural killer T cells precedes the onset of lupus. Clin Exp Immunol. 2013;173:18-27 pubmed publisher
    ..Thus, iNK?T cells are functionally insufficient in lupus-prone BWF(1) mice. Such iNK?T cell insufficiency precedes the onset of disease and may play a pathogenic role during early stages of disease development in SLE. ..
  14. Busser B, Adair B, Erikson J, Laufer T. Activation of diverse repertoires of autoreactive T cells enhances the loss of anti-dsDNA B cell tolerance. J Clin Invest. 2003;112:1361-71 pubmed
    ..These data demonstrate that a diverse CD4+ T cell repertoire is required to generate a sustained effector B cell response capable of mediating systemic autoimmunity. ..
  15. Seagal J, Melamed D. Contribution of alphabeta and gammadelta T cells to the generation of primary immunoglobulin G-driven autoimmune response in immunoglobulin- mu-deficient/lpr mice. Immunology. 2004;112:265-73 pubmed
  16. Hou S, Mo X, Hyland L, Doherty P. Host response to Sendai virus in mice lacking class II major histocompatibility complex glycoproteins. J Virol. 1995;69:1429-34 pubmed
    ..As found previously with CD4-depleted H-2b mice, the development of Sendai virus-specific CD8+ T-cell-mediated immunity is not compromised by the absence of a concurrent class II major histocompatibility complex-restricted response. ..
  17. Bugeon L, Dallman M. Costimulation of T cells. Am J Respir Crit Care Med. 2000;162:S164-8 pubmed
    ..While cd80 and cd86 pathways act mainly on naive T cells, B7h/B7RP-1 and B7-H1 seem to exert their effects on antigen-experienced lymphocytes. ..
  18. Kizil G, Todd I, Atta M, Borriello S, Ait Tahar K, Ala Aldeen D. Identification and characterization of TspA, a major CD4(+) T-cell- and B-cell-stimulating Neisseria-specific antigen. Infect Immun. 1999;67:3533-41 pubmed
    ..Thus, we have identified a novel neisserial protein (TspA) which proved to be a strong CD4(+) T-cell- and B-cell-stimulating immunogen with potential as a possible vaccine candidate...
  19. Arnaboldi P, Roth Walter F, Mayer L. Suppression of Th1 and Th17, but not Th2, responses in a CD8(+) T cell-mediated model of oral tolerance. Mucosal Immunol. 2009;2:427-38 pubmed publisher
    ..Thus, CD8(+) T cells are functionally capable of mediating tolerance to Th1 and Th17 responses. ..
  20. Cai G, Nie X, Zhang W, Wu B, Lin J, Wang H, et al. A regulatory role for IL-10 receptor signaling in development and B cell help of T follicular helper cells in mice. J Immunol. 2012;189:1294-302 pubmed publisher
    ..Our results provide useful information for clarifying the immunoregulatory mechanisms associated with IL-10 deficiency in certain autoimmune disease models. This information could also be of benefit for the development of vaccines. ..
  21. Munthe L, Corthay A, Os A, Zangani M, Bogen B. Systemic autoimmune disease caused by autoreactive B cells that receive chronic help from Ig V region-specific T cells. J Immunol. 2005;175:2391-400 pubmed
  22. Song A, Song J, Tang X, Croft M. Cooperation between CD4 and CD8 T cells for anti-tumor activity is enhanced by OX40 signals. Eur J Immunol. 2007;37:1224-32 pubmed
    ..OX40 therefore represents an important signal for allowing effective cooperation between CD4 and CD8 cells and for promoting cell interplay and tumor rejection where CD8 activity is limiting. ..
  23. Sweet R, Ols M, Cullen J, Milam A, Yagita H, Shlomchik M. Facultative role for T cells in extrafollicular Toll-like receptor-dependent autoreactive B-cell responses in vivo. Proc Natl Acad Sci U S A. 2011;108:7932-7 pubmed publisher
  24. Fazekas de St Groth B, Cook M, Smith A. The role of T cells in the regulation of B cell tolerance. Int Rev Immunol. 1997;15:73-99 pubmed
  25. Sobel E, Kakkanaiah V, Kakkanaiah M, Cohen P, Eisenberg R. Co-infusion of normal bone marrow partially corrects the gld T-cell defect. Evidence for an intrinsic and extrinsic role for Fas ligand. J Immunol. 1995;154:459-64 pubmed
    ..Surprisingly, the residual CD4-CD8- T cells present in the mixed chimeras were derived entirely from the gld donor marrow. This suggests that the gld mutation results in both an extrinsic and intrinsic defect in T cells...
  26. Rademaekers A, Kölsch E, Specht C. T cell mediated antibody invariance in an immune response against a bacterial carbohydrate antigen requires CD28/B7-1 costimulation. Dev Immunol. 2001;8:243-57 pubmed
  27. Heath W, Carbone F. Cytotoxic T lymphocyte activation by cross-priming. Curr Opin Immunol. 1999;11:314-8 pubmed
  28. Sad S, Marcotte R, Mosmann T. Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines. Immunity. 1995;2:271-9 pubmed
    ..We propose the names TC1 and TC2 for cytotoxic CD8+ T cells secreting Th1-like and Th2-like cytokines, respectively. ..
  29. Barcy S, Corey L. Herpes simplex inhibits the capacity of lymphoblastoid B cell lines to stimulate CD4+ T cells. J Immunol. 2001;166:6242-9 pubmed
    ..These data indicate a novel immune evasion strategy by HSV-1 in which Ag-processing cells that become infected by HSV-1 are inhibited in their ability to induce subsequent CD4(+) T cell activation. ..
  30. Constant S, Schweitzer N, West J, Ranney P, Bottomly K. B lymphocytes can be competent antigen-presenting cells for priming CD4+ T cells to protein antigens in vivo. J Immunol. 1995;155:3734-41 pubmed
  31. Weisel F, Wellmann U, Winkler T. Autoreactive B cells get activated in extrafollicular sites. Eur J Immunol. 2007;37:3330-3 pubmed
    ..The differentiation and hypermutation of autoreactive B cells takes place at extrafollicular sites. ..
  32. Morimoto C, Reinherz E, Borel Y, Mantzouranis E, Steinberg A, Schlossman S. Autoantibody to an immunoregulatory inducer population in patients with juvenile rheumatoid arthritis. J Clin Invest. 1981;67:753-61 pubmed
    ..These results suggest that the JRA serum may define a Qal-like antigen found predominantly on the human inducer population which could activate suppressor and/or other feedback regulatory cells. ..
  33. Panchanathan V, Chaudhri G, Karupiah G. Correlates of protective immunity in poxvirus infection: where does antibody stand?. Immunol Cell Biol. 2008;86:80-6 pubmed
    ..These findings have important clinical implications and would greatly assist the design of therapeutic interventions and new vaccines for smallpox. ..
  34. Kaminski D, Lee B, Eaton S, Haynes L, Randall T. CD28 and inducible costimulator (ICOS) signalling can sustain CD154 expression on activated T cells. Immunology. 2009;127:373-85 pubmed publisher
    ..These results demonstrate that TCR signalling and costimulation each regulate different phases of CD154 expression and control the biological outcome of CD40 signalling on B cells. ..
  35. Stel A, Kroesen B, Jacobs S, Groen H, de Leij L, Kluin Nelemans H, et al. The role of B cell-mediated T cell costimulation in the efficacy of the T cell retargeting bispecific antibody BIS20x3. J Immunol. 2004;173:6009-16 pubmed
    ..Together these results demonstrate that the malignant B cells actively contribute to their own demise upon CD20-directed bispecific Ab-mediated T cell targeting. ..
  36. Gonzalez Quintela A, Alende M, Lojo S, Perez L, Padin E, Tome S, et al. Total serum IgE levels in chronic hepatitis C: influence of interferon alpha therapy. Int Arch Allergy Immunol. 2001;125:176-81 pubmed
    ..Interferon-alpha therapy in patients with chronic hepatitis C is followed by no modification or even a moderate increase of serum IgE values. ..
  37. Dayer J. How T-lymphocytes are activated and become activators by cell-cell interaction. Eur Respir J Suppl. 2003;44:10s-15s pubmed
  38. Mattern T, Girroleit G, Flad H, Rietschel E, Ulmer A. CD34(+) hematopoietic stem cells exert accessory function in lipopolysaccharide-induced T cell stimulation and CD80 expression on monocytes. J Exp Med. 1999;189:693-700 pubmed
    ..These findings may be of relevance for high risk patients treated with stem cells or stem cell recruiting compounds and for patients suffering from endotoxin-mediated diseases. ..
  39. Dustin M. Signaling at neuro/immune synapses. J Clin Invest. 2012;122:1149-55 pubmed publisher
    ..A better understanding of the shared mechanisms between immunological and neural synapses could aid in the development of new therapeutic modalities for immunological, neurological, and neuroimmunological disorders alike. ..
  40. Zhang G, Xiao B, Bakhiet M, van der Meide P, Wigzell H, Link H, et al. Both CD4+ and CD8+ T cells are essential to induce experimental autoimmune myasthenia gravis. J Exp Med. 1996;184:349-56 pubmed
  41. Nguyen V, Luzina I, Rus H, Tegla C, Chen C, Rus V. IL-21 promotes lupus-like disease in chronic graft-versus-host disease through both CD4 T cell- and B cell-intrinsic mechanisms. J Immunol. 2012;189:1081-93 pubmed publisher
  42. Kiyono H, Mosteller L, Eldridge J, Michalek S, McGhee J. IgA responses in xid mice: oral antigen primes Peyer's patch cells for in vitro immune responses and secretory antibody production. J Immunol. 1983;131:2616-22 pubmed
    ..abstract truncated at 400 words) ..
  43. Kumar A, Angel J, Aucoin S, Creery W, Daftarian M, Cameron D, et al. Dysregulation of B7.2 (CD86) expression on monocytes of HIV-infected individuals is associated with altered production of IL-2. Clin Exp Immunol. 1999;117:84-91 pubmed
    ..These observations showing an association of B7 dysregulation on monocytes and B cells with altered production of IL-2 may have implications in HIV immunopathogenesis. ..
  44. Nakae S, Komiyama Y, Nambu A, Sudo K, Iwase M, Homma I, et al. Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity. 2002;17:375-87 pubmed
    ..Our findings indicate that IL-17 plays an important role in activating T cells in allergen-specific T cell-mediated immune responses. ..
  45. Takamatsu H, Denyer M, Stirling C, Cox S, Aggarwal N, Dash P, et al. Porcine gammadelta T cells: possible roles on the innate and adaptive immune responses following virus infection. Vet Immunol Immunopathol. 2006;112:49-61 pubmed
    ..This direct interaction between gammadelta T cells and CD4(+) T cells is likely to have a significant influence on the out come of the adaptive immune response. ..
  46. Groth C, Drager R, Warnatz K, Wolff Vorbeck G, Schmidt S, Eibel H, et al. Impaired up-regulation of CD70 and CD86 in naive (CD27-) B cells from patients with common variable immunodeficiency (CVID). Clin Exp Immunol. 2002;129:133-9 pubmed
    ..These findings strongly suggest an intrinsic signalling or expression defect for CD70/CD86 at the level of naive B cells in type I CVID patients. ..
  47. Rossi D, Gaidano G. Anaplastic large cell lymphoma and acquired angioedema: a novel association?. Ann Ital Med Int. 2002;17:143-5 pubmed
  48. Rothstein T, Griffin D, Holodick N, Quách T, Kaku H. Human B-1 cells take the stage. Ann N Y Acad Sci. 2013;1285:97-114 pubmed publisher
    ..Manipulation of human B-1 cell numbers and/or activity may be a new avenue for altering T cell function and treating immune dyscrasias. ..
  49. Agliari E, Barra A, Guerra F, Moauro F. A thermodynamic perspective of immune capabilities. J Theor Biol. 2011;287:48-63 pubmed publisher
    ..e. B and killer lymphocytes) can be modeled in terms of a stochastic process, ultimately providing a consistent bridge between the tripartite-network approach introduced here and the immune networks developed in the last decades. ..
  50. Kemp J, Rohrer J, Huber B. Lyb3: a B cell surface antigen associated with triggering secretory differentiation. Immunol Rev. 1982;69:127-40 pubmed
  51. Lund F, Hollifield M, Schuer K, Lines J, Randall T, Garvy B. B cells are required for generation of protective effector and memory CD4 cells in response to Pneumocystis lung infection. J Immunol. 2006;176:6147-54 pubmed
    ..These data indicate that B cells play a vital role in generation of CD4(+) memory T cells in response to PC infection in the lungs. ..
  52. Fujii T, Okada M, Craft J. Regulation of T cell-dependent autoantibody production by a gammadelta T cell line derived from lupus-prone mice. Cell Immunol. 2002;217:23-35 pubmed
    ..These findings prove that we have identtified a gammadelta T cell line that suppresses autoantibody synthesis by alphabeta T-B cell collaboration in vitro. ..
  53. Cook M, Basten A, Fazekas de St Groth B. Rescue of self-reactive B cells by provision of T cell help in vivo. Eur J Immunol. 1998;28:2549-58 pubmed