immunoproliferative disorders

Summary

Summary: Disorders characterized by abnormal proliferation of primary cells of the immune system or by excessive production of immunoglobulins.

Top Publications

  1. Vossen M, Gent M, Davin J, Baars P, Wertheim van Dillen P, Weel J, et al. Spontaneous outgrowth of EBV-transformed B-cells reflects EBV-specific immunity in vivo; a useful tool in the follow-up of EBV-driven immunoproliferative disorders in allograft recipients. Transpl Int. 2004;17:89-96 pubmed
  2. Grosbois B, Jego P, de Rosa H, Ruelland A, Lancien G, Gallou G, et al. [Triclonal gammopathy and malignant immunoproliferative syndrome]. Rev Med Interne. 1997;18:470-3 pubmed
    ..The origin of three distinct monoclonal proteins may derive from three unrelated clones or alternatively from a single clone in which an isotype switch has occurred...
  3. Pasqualetti P, Casale R. Risk of malignant transformation in patients with monoclonal gammopathy of undetermined significance. Biomed Pharmacother. 1997;51:74-8 pubmed
    ..Since no clinical or laboratory features are able to identify in advance the patients at high risk of disease progression, each patient must be followed up periodically and over an indefinite period...
  4. Michal M, Koza V, Jindra P. Spindle cell tumor of lymph node of probable reticulum cell origin associated with multiclonal gammopathy. Zentralbl Pathol. 1994;140:165-72 pubmed
    ..We diagnosed the tumor as "spindle cell tumor of lymph node of probable reticulum cell origin associated with multiclonal gammopathy" and consider the lymphoid tissue producing the paraprotein to be reactive...
  5. Curci G, Frassoldati A, Zioni F, Zaniol P, Piccinini L. Plasma fibronectin in hemoblastosis. Int J Biol Markers. 1987;2:71-4 pubmed
    ..The results suggest a poor relationship between FN levels and the course of the disease. However, the behaviour of the protein in relation with treatment was dynamic...
  6. Peterson L, Kueck B, Arthur D, Dedeker K, Brunning R. Systemic polyclonal immunoblastic proliferations. Cancer. 1988;61:1350-8 pubmed
    ..The immunohistochemical results suggest a reactive, polyclonal proliferation, but the cytogenetic abnormalities in two patients indicate the possibility of a cryptic neoplastic clone...
  7. Siminovitch K, Chen P. The biologic significance of human natural autoimmune responses: relationship to the germline, early immune and malignant B cell variable gene repertoire. Int Rev Immunol. 1990;5:265-77 pubmed
  8. Ho F, Choy D, Loke S, Kung I, Fu K, Liang R, et al. Polymorphic reticulosis and conventional lymphomas of the nose and upper aerodigestive tract: a clinicopathologic study of 70 cases, and immunophenotypic studies of 16 cases. Hum Pathol. 1990;21:1041-50 pubmed
    ..In the PR and ML[PR] biopsies, angiocentricity was detected in 11%, and angioinvasion in 22%. We could not confirm identity of PR with other angiocentric immunoproliferative lesions...
  9. Dickson D, Belman A, Park Y, Wiley C, Horoupian D, Llena J, et al. Central nervous system pathology in pediatric AIDS: an autopsy study. APMIS Suppl. 1989;8:40-57 pubmed
    ..Two children had a necrotizing encephalopathy with encephalomalacia and vascular changes suggestive of a mitochondrial cytopathy.(ABSTRACT TRUNCATED AT 250 WORDS)..

More Information

Publications50

  1. Zenone T, Souillet G. [Cancer and primary humoral immunodeficiency]. Bull Cancer. 1997;84:813-21 pubmed
    ..A literature review is presented on this subject with analysis of case reports, prospective and retrospective studies, and data from the Minnesota Immunodeficiency Cancer Registry...
  2. Wassberg C, Thorn M, Yuen J, Ringborg U, Hakulinen T. Second primary cancers in patients with cutaneous malignant melanoma: a population-based study in Sweden. Br J Cancer. 1996;73:255-9 pubmed
    ..03-1.88), but no significant associations existed for cancers of the breast, ovary, testis or other endocrine glands. Among tumours of the digestive tract, only colon cancer in men had a significantly increased SIR (1.33, CI = 1.00-1.74)...
  3. Baker A, Davis D, Berg K. Polyclonal systemic immunoblast proliferation: an unusual hematologic entity presenting as a medical examiner case. J Forensic Sci. 2001;46:156-9 pubmed
    ..We review the literature on this unusual entity and discuss the clinical and pathologic findings...
  4. Sonakul D, Pacharee P. Immunoperoxidase study on paraffin sections of gastrointestinal lymphoreticular lesions. Southeast Asian J Trop Med Public Health. 1987;18:467-78 pubmed
    ..One of 18 cases of mixed and small cell lymphoma was accompanied by IPD. In these types of lymphoma Ig was found only in 10-30% of cells, mainly with plasmacytoid differentiation...
  5. Schurmann D, Ruf B, Pfannkuch F, Horbach I, Pohle H. Fatal legionellosis in patients with malignant hematologic diseases. Blut. 1988;56:27-31 pubmed
    ..In view of the common occurrence of relapses of Legionella pneumonia, antibiotic therapy should be continued for an extended period...
  6. Boulware M, Heisler J, Frick K. The memory-enhancing effects of hippocampal estrogen receptor activation involve metabotropic glutamate receptor signaling. J Neurosci. 2013;33:15184-94 pubmed publisher
    ..Together, these findings provide the first in vivo evidence demonstrating that ER/mGluR signaling can mediate the beneficial effects of E2 on hippocampal memory consolidation. ..
  7. Iwamoto M, Akasu F, Sakihama T, Onaya T, Nakajima Y, Tasaka K. Serum IgG from an autoimmune prone mouse C3H/HeJ-gld/gld supports the interleukin-3-dependent cell line through an autocrine mechanism. Cell Immunol. 1990;125:151-9 pubmed
    ..Thus, cytokines produced by serum IgG may play an important role in the development of disease in mice bearing the autosomal recessive mutation gld...
  8. Antoniades K, Hatzistilianou M, Pitsavas G, Agouridaki C, Athanassiadou F. Co-existence of Dubowitz and hyper-IgE syndromes: a case report. Eur J Pediatr. 1996;155:390-2 pubmed
    ..The co-existence of these two syndromes is rare and we suggest that this is the first such case in the literature...
  9. Tanaka Y, Sasaki Y, Kurozumi H, Hyodo Y, Nishi T, Nakatani Y, et al. Angiocentric immunoproliferative lesion associated with chronic active Epstein-Barr virus infection in an 11-year-old boy. Clonotopic proliferation of Epstein-Barr virus-bearing CD4+ T lymphocytes. Am J Surg Pathol. 1994;18:623-31 pubmed
  10. Gleissner B, Maurer J, Thiel E. Detection of immunoglobulin heavy chain genes rearrangements in B-cell leukemias, lymphomas, multiple myelomas, monoclonal and polyclonal gammopathies. Leuk Lymphoma. 2000;39:151-5 pubmed
    ..Some additional monoclonal products can be seen with CDR I-based PCR. Detection of monoclonality depends on the maturation grade of the neoplastic B-cell population...
  11. Frigeri F, De Renzo A, Marceno R, Ruggeri P, Musto P, Andriani A, et al. Effect of alpha IFN on unaggressive immunoproliferative disorders. Haematologica. 1995;80:35-9 pubmed
    alpha-IFN is reported to be an effective treatment for a number of lymphoproliferative diseases. Little information is available at present on its effect in unaggressive immunoproliferative disorders.
  12. Ichiki Y, Osaki T, Yamashita T, Oyama T, Sugio K, Yasumoto K. Angiocentric immunoproliferative lesion of the lung. Jpn J Thorac Cardiovasc Surg. 2002;50:353-5 pubmed
    ..Because tumor markers such as serum LDH and soluble IL-2 receptor increased postoperatively, we conducted systemic chemotherapy, after which elevated serum tumor markers decreased...
  13. Perrino C, Naga Prasad S, Patel M, Wolf M, Rockman H. Targeted inhibition of beta-adrenergic receptor kinase-1-associated phosphoinositide-3 kinase activity preserves beta-adrenergic receptor signaling and prolongs survival in heart failure induced by calsequestrin overexpression. J Am Coll Cardiol. 2005;45:1862-70 pubmed
    ..Desensitization and down-regulation of beta-adrenergic receptors (betaARs) are prominent features of heart failure largely mediated by increased levels of betaAR kinase-1 (betaARK1)...
  14. Okada S, Wada J, Tsukinoki T, Hirano N, Watanabe Y, Shikata K, et al. Angiocentric immunoproliferative lesions of the lung associated with diffuse renal involvement. Am J Kidney Dis. 2002;39:E12 pubmed
    ..We recommend the imaging of kidneys for diagnosis and following renal biopsy to evaluate the renal involvement of angiocentric immunoproliferative lesions...
  15. Arland M, Nebe T, Parwaresch R, Tiemann M, Ranze O, Kr├╝ger W, et al. Transient clonal expansion of large granular lymphocytes in a patient with LGL syndrome. Ann Hematol. 2006;85:60-2 pubmed
  16. Katzmann J, Kyle R, Benson J, Larson D, Snyder M, Lust J, et al. Screening panels for detection of monoclonal gammopathies. Clin Chem. 2009;55:1517-22 pubmed publisher
    ..Although there are several reports on the relative diagnostic contribution of these assays, none has looked at the tests singly and in combination for the various plasma cell proliferative disorders (PCPDs)...
  17. Olteanu H, Harrington A, Kroft S. CD200 expression in plasma cells of nonmyeloma immunoproliferative disorders: clinicopathologic features and comparison with plasma cell myeloma. Am J Clin Pathol. 2012;138:867-76 pubmed publisher
    ..There are no flow cytometry data in the literature on plasma cell CD200 expression in other immunoproliferative disorders. Therefore we used flow cytometry to study the expression of CD200 on plasma cells in diagnostic bone ..
  18. Drut R, Drut R. Angiocentric immunoproliferative lesion and angiocentric lymphoma of lymph node in children. A report of two cases. J Clin Pathol. 2005;58:550-2 pubmed
    ..Most commonly involving extranodal sites, AIL/AL rarely presents in the spleen and lymph nodes...
  19. Ferone D, Arvigo M, Semino C, Pivonello R, van Hagen P, Barreca A, et al. The role of somatostatin analogs in the management of immunoproliferative disease. J Endocrinol Invest. 2003;26:103-8 pubmed
  20. Csanaky G, de Bruin P, Hegedus G, Schreiner M, Baliko Z. [Angiocentric T-cell lymphoma of the lung]. Orv Hetil. 1996;137:473-6 pubmed
    ..Authors refer to some recent findings which may give new insights in the pathobiology of extranodal T-cell lymphomas, and result in recognition of new disease entities...
  21. Lust J. Role of cytokines in the pathogenesis of monoclonal gammopathies. Mayo Clin Proc. 1994;69:691-7 pubmed
    ..To review data that postulate a role for cytokines and oncogenes in the pathogenesis of monoclonal gammopathies...
  22. Bhagat M, Sehra S, Shahane A, Kwan M. Utility of immunologic testing in suspected rheumatologic disease. Curr Allergy Asthma Rep. 2014;14:405 pubmed publisher
    ..In particular, we will focus on the anti-nuclear antibodies, anti-neutrophil cytoplasmic antibodies, complement, cryoglobulins, rheumatoid factor, and anti-citrullinated protein antibodies. ..
  23. Pezzoli A, Pascali E. The clinical significance of pure Bence Jones proteinuria at low concentration. Am J Clin Pathol. 1989;91:473-5 pubmed
    ..Five patients (15%) had no evidence of definite malignant immunoproliferative disorders at the time of recognition of BJ proteinuria...
  24. Peiper S, Myers J, Broussard E, Sixbey J. Detection of Epstein-Barr virus genomes in archival tissues by polymerase chain reaction. Arch Pathol Lab Med. 1990;114:711-4 pubmed
    ..mononucleosis, in various tissues from seven immunosuppressed organ transplant recipients with immunoproliferative disorders, and in small biopsy specimens from a patient with nasopharyngeal carcinoma...
  25. Wang J, Jeelall Y, Beutler B, Horikawa K, Goodnow C. Consequences of the recurrent MYD88(L265P) somatic mutation for B cell tolerance. J Exp Med. 2014;211:413-26 pubmed publisher
  26. Mensah K, Ritchlin C, Schwarz E. RANKL induces heterogeneous DC-STAMP(lo) and DC-STAMP(hi) osteoclast precursors of which the DC-STAMP(lo) precursors are the master fusogens. J Cell Physiol. 2010;223:76-83 pubmed publisher
    ..RANKL induces osteoclastogenesis by stimulating DC-STAMP internalization in some OCP, and these DC-STAMP(lo) cells display the "master fusogen" phenotype. In contrast, DC-STAMP(hi) OCP can only act as mononuclear donors...
  27. Niemela J, Lu L, Fleisher T, Davis J, Caminha I, Natter M, et al. Somatic KRAS mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasis. Blood. 2011;117:2883-6 pubmed publisher
    ..We suggest the use of the term RAS-associated autoimmune leukoproliferative disease to differentiate this disorder from autoimmune lymphoproliferative syndrome...
  28. Ko H, Hernandez Prera J, Zhu H, Dikman S, Sidhu H, Ward S, et al. Morphologic features of extrahepatic manifestations of hepatitis C virus infection. Clin Dev Immunol. 2012;2012:740138 pubmed publisher
    ..This paper highlights the histomorphologic features of these processes, which are typically characterized by chronic inflammation, immune complex deposition, and immunoproliferative disease in the affected organ...
  29. Mino Y, Naito T, Watanabe T, Yamada T, Yagi T, Yamada H, et al. Hydroxy-itraconazole pharmacokinetics is similar to that of itraconazole in immunocompromised patients receiving oral solution of itraconazole. Clin Chim Acta. 2013;415:128-32 pubmed publisher
    ..The pharmacokinetic variability of hydroxy-itraconazole (OH-ITZ), an active metabolite of itraconazole (ITZ), is not fully known...
  30. Pascali E, Pezzoli A. The clinical spectrum of pure Bence Jones proteinuria. A study of 66 patients. Cancer. 1988;62:2408-15 pubmed
    ..for serum and urine monoclonal immunoglobulins were studied in order to better define the spectrum of immunoproliferative disorders associated with such a protein abnormality...
  31. Daum G, Sullivan J, Ansell J, Mulder C, Woda B. Virus-associated hemophagocytic syndrome: identification of an immunoproliferative precursor lesion. Hum Pathol. 1987;18:1071-4 pubmed
    ..This finding suggests that some cases of VAHS may have an immunoproliferative precursor lesion...
  32. Jaffe R, Trager J, Zeevi A, Sonmez Alpan E, Duquesnoy R, Todo S, et al. Multivisceral intestinal transplantation: surgical pathology. Pediatr Pathol. 1989;9:633-54 pubmed
    ..Bacterial translocation through the gut wall was also a feature in both children. This paper documents and illustrates the various diagnostic possibilities...
  33. Peter H, Hartel R, Lang B, Weber S. [Chronic immunoproliferative syndromes]. Immun Infekt. 1991;19:73-7 pubmed
    ..We favor the notion that CPIS is a variant form of AILD clinically dominated by severe autoimmune hemolytic anemia. Both diseases share the high frequency of anti-cytoskeleton autoantibodies...
  34. Medeiros L, Peiper S, Elwood L, Yano T, Raffeld M, Jaffe E. Angiocentric immunoproliferative lesions: a molecular analysis of eight cases. Hum Pathol. 1991;22:1150-7 pubmed
    ..These findings further emphasize the unique clinicopathologic aspects of AILs and may also be useful diagnostically in the differential diagnosis of lymphoproliferative disorders...
  35. Lee S, Kim J, Han A, Hur S, Kim C, Kim T, et al. Intravenous Immunoglobulin G Improves Pregnancy Outcome in Women with Recurrent Pregnancy Losses with Cellular Immune Abnormalities. Am J Reprod Immunol. 2016;75:59-68 pubmed publisher
    ..We investigated the therapeutic effect of intravenous immunoglobulin (IVIG) in women with recurrent pregnancy loss (RPL)...
  36. Rampling M. Hyperviscosity as a complication in a variety of disorders. Semin Thromb Hemost. 2003;29:459-65 pubmed
    ..The details of the causes of the hyperviscosity, the symptoms that result, and the forms of treatment are discussed...
  37. Mizuno T, Takanashi Y, Onodera H, Shigeta M, Tanaka N, Yuya H, et al. A case of lymphomatoid granulomatosis/angiocentric immunoproliferative lesion with long clinical course and diffuse brain involvement. J Neurol Sci. 2003;213:67-76 pubmed
    ..Cyclophosphamide was effective and there has been no recurrence of symptoms in the last 5 years. We reviewed the non-tumorous LYG/AIL involving the CNS, and discussed the clinical features, MRI imaging and diagnosis of the LYG/AIL...
  38. Spohr A, Koch J, Jensen A. Ultrasonographic findings in a basenji with immuno-proliferative enteropathy. J Small Anim Pract. 1995;36:79-82 pubmed
    ..Thus, the ultrasonographic finding of generalised thickening of the intestinal wall in a basenji presenting with chronic diarrhoea, weight loss, anorexia or vomiting is strongly indicative of immunoproliferative enteropathy...
  39. Denning S, Haynes B. Differentiation of human T cells. Clin Lab Med. 1988;8:1-14 pubmed
    ..The impact of monoclonal antibody technology, the discovery of the T-cell receptor for antigen, and the discovery of mechanisms of thymocyte-thymic microenvironment interactions on the analysis of human T-cell development are emphasized...
  40. Buxbaum J, Chuba J, Hellman G, Solomon A, Gallo G. Monoclonal immunoglobulin deposition disease: light chain and light and heavy chain deposition diseases and their relation to light chain amyloidosis. Clinical features, immunopathology, and molecular analysis. Ann Intern Med. 1990;112:455-64 pubmed
    ..Bone marrow cells from patients with either type produce immunoglobulin fragments that are related to those deposited in the affected tissues...
  41. Homma K, Umezu H, Nemoto K, Ohnishi Y, Sekine A, Yoshioka K. Angiocentric immunoproliferative lesion of the stomach. Virchows Arch A Pathol Anat Histopathol. 1991;418:267-70 pubmed
    ..A survey of the literature suggests that AIL is a spectrum of T-lymphocyte proliferative disorders. To our knowledge, this is the first case of AIL involving the stomach primarily...