Summary: Rapidly decreasing response to a drug or physiologically active agent after administration of a few doses. In immunology, it is the rapid immunization against the effect of toxic doses of an extract or serum by previous injection of small doses. (Dorland, 28th ed)

Top Publications

  1. Matsuda H, Murakami T, Kishi A, Yoshikawa M. Structures of withanosides I, II, III, IV, V, VI, and VII, new withanolide glycosides, from the roots of Indian Withania somnifera DUNAL. and inhibitory activity for tachyphylaxis to clonidine in isolated guinea-pig ileum. Bioorg Med Chem. 2001;9:1499-507 pubmed
    ..Principal constituents, withanoside VI (10 and 30 microM) and withaferin A (10 microM), attenuated the tachyphylaxis to clonidine on electrically stimulated guinea-pig ileum in vitro.
  2. Chen X, Grunder S. Permeating protons contribute to tachyphylaxis of the acid-sensing ion channel (ASIC) 1a. J Physiol. 2007;579:657-70 pubmed
    ..Such a reduced response is called tachyphylaxis. We show that tachyphylaxis depends on H+ permeating through ASIC1a, that tachyphylaxis is attenuated by ..
  3. Amsterdam J, Shults J. Does tachyphylaxis occur after repeated antidepressant exposure in patients with Bipolar II major depressive episode?. J Affect Disord. 2009;115:234-40 pubmed publisher
    b>Tachyphylaxis often refers to the loss of antidepressant efficacy during long-term treatment. However, it may also refer to the gradual loss of efficacy after repeated antidepressant exposures over time...
  4. Garzón J, Rodríguez Muñoz M, López Fando A, Garcia Espana A, Sánchez Blázquez P. RGSZ1 and GAIP regulate mu- but not delta-opioid receptors in mouse CNS: role in tachyphylaxis and acute tolerance. Neuropsychopharmacology. 2004;29:1091-104 pubmed
    ..Thus, in naive mice, morphine tachyphylaxis originated in the presence of the opioid agonist and during the analgesia time course...
  5. Garzon J, Sánchez Blázquez P. Administration of myr(+)-G(i2)alpha subunits prevents acute tolerance (tachyphylaxis) to mu-opioid effects in mice. Neuropharmacology. 2001;40:560-9 pubmed
    The administration of efficacious doses of morphine or beta-endorphin causes acute tolerance (tachyphylaxis) to the effects of additional administrations of these opioids...
  6. El Galley R, Rutland H, Talic R, Keane T, Clark H. Long-term efficacy of sildenafil and tachyphylaxis effect. J Urol. 2001;166:927-31 pubmed
    ..Our data suggest that there is a possible tachyphylaxis effect with sildenafil...
  7. Crujeiras A, Parra D, Goyenechea E, Abete I, Martinez J. Tachyphylaxis effects on postprandial oxidative stress and mitochondrial-related gene expression in overweight subjects after a period of energy restriction. Eur J Nutr. 2009;48:341-7 pubmed publisher
    ..Indeed, the COX15 and MGST2 gene expression assays in PBMC emerged as valuable nutrigenomic biomarkers of the oxidative response under energy-restriction conditions. ..
  8. Feldman S. Tachyphylaxis to topical corticosteroids: the more you use them, the less they work?. Clin Dermatol. 2006;24:229-30; discussion 230 pubmed
  9. Zimmerman M, Thongy T. How often do SSRIs and other new-generation antidepressants lose their effect during continuation treatment? Evidence suggesting the rate of true tachyphylaxis during continuation treatment is low. J Clin Psychiatry. 2007;68:1271-6 pubmed
    ..published from 1980 to 2005 in 23 prespecified journals, using the search terms depression, continuation, and tachyphylaxis). Finally, we identified studies in reference lists of pertinent studies and review articles...

More Information


  1. Telleria J, Blanco Quiros A, Muntion S, Antonio Garrote J, Arranz E, Armentia A, et al. Tachyphylaxis to beta2-agonists in Spanish asthmatic patients could be modulated by beta2-adrenoceptor gene polymorphisms. Respir Med. 2006;100:1072-8 pubmed
    ..Based on the standard criteria, patients were classified into two groups: patients with tachyphylaxis and good responders to beta(2)-agonist therapy...
  2. Lamian V, Rich A, Ma Z, Li J, Seethala R, Gordon D, et al. Characterization of agonist-induced motilin receptor trafficking and its implications for tachyphylaxis. Mol Pharmacol. 2006;69:109-18 pubmed
    ..However, long-term clinical use of certain MR agonists is limited by tachyphylaxis, a reduced responsiveness to repeated compound exposure...
  3. Posternak M, Zimmerman M. Dual reuptake inhibitors incur lower rates of tachyphylaxis than selective serotonin reuptake inhibitors: a retrospective study. J Clin Psychiatry. 2005;66:705-7 pubmed
    ..SSRIs) may be associated with higher relapse rates than other antidepressants during maintenance treatment (tachyphylaxis) has been discussed for years, but to date there is little or no empirical evidence confirming this phenomenon...
  4. Behr Roussel D, Gorny D, Mevel K, Caisey S, Bernabe J, Burgess G, et al. Chronic sildenafil improves erectile function and endothelium-dependent cavernosal relaxations in rats: lack of tachyphylaxis. Eur Urol. 2005;47:87-91 pubmed
    ..Chronic sildenafil may regulate the transduction pathway leading to the activation of eNOS but has no effect on NO bioavailability or on the cGMP pathway, thereby eliminating a possible concern for tachyphylaxis.
  5. Lin G, Xin Z, Lue T, Lin C. Up and down-regulation of phosphodiesterase-5 as related to tachyphylaxis and priapism. J Urol. 2003;170:S15-8; discussion S19 pubmed
    We identify whether tachyphylaxis and priapism effects of sildenafil are related to regulation of phosphodiesterase-5 (PDE-5) expression.
  6. Jayasena C, Nijher G, Chaudhri O, Murphy K, Ranger A, Lim A, et al. Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis. J Clin Endocrinol Metab. 2009;94:4315-23 pubmed publisher
    ..These data have important implications for the development of kisspeptin as a novel therapy for reproductive disorders in humans. ..
  7. An S, Wang W, Koziol White C, Ahn K, Lee D, Kurten R, et al. TAS2R activation promotes airway smooth muscle relaxation despite β(2)-adrenergic receptor tachyphylaxis. Am J Physiol Lung Cell Mol Physiol. 2012;303:L304-11 pubmed publisher
    ..These findings portend a favorable therapeutic profile for TAS2R agonists for the treatment of bronchospasm in asthma or chronic obstructive lung disease. ..
  8. Sarria I, Ling J, Zhu M, Gu J. TRPM8 acute desensitization is mediated by calmodulin and requires PIP(2): distinction from tachyphylaxis. J Neurophysiol. 2011;106:3056-66 pubmed publisher
    ..functional downregulation of TRPM8 is manifested with two distinctive phases, acute desensitization and tachyphylaxis. Here we show in rat dorsal root ganglion neurons that TRPM8 acute desensitization critically depends on ..
  9. Gasperini J, Fawzi A, Khondkaryan A, Lam L, Chong L, Eliott D, et al. Bevacizumab and ranibizumab tachyphylaxis in the treatment of choroidal neovascularisation. Br J Ophthalmol. 2012;96:14-20 pubmed publisher
    To evaluate the effect of switching to bevacizumab or ranibizumab after developing tachyphylaxis during anti-vascular endothelial growth factor (VEGF) therapy for choroidal neovascularisation (CNV)...
  10. Eghøj M, Sørensen T. Tachyphylaxis during treatment of exudative age-related macular degeneration with ranibizumab. Br J Ophthalmol. 2012;96:21-3 pubmed publisher
    To determine whether tachyphylaxis occurs during treatment with ranibizumab (Lucentis, Genentech, Inc., South San Francisco, California, USA) for exudative age-related macular degeneration (AMD). Retrospective review of cases...
  11. van Riemsdijk I, Baan C, Loonen E, Knoop C, Navarro Betonico G, Niesters H, et al. T cells activate the tumor necrosis factor-alpha system during hemodialysis, resulting in tachyphylaxis. Kidney Int. 2001;59:883-92 pubmed
    ..the TNF-alpha system is activated during HD, the TNF-alpha production of T cells is impaired, suggesting that tachyphylaxis of T cells occurs for TNF-alpha, as their proliferative capacity and IL-2 production capacity do not imply an ..
  12. Vaidyanathan S, Williamson P, Clearie K, Khan F, Lipworth B. Fluticasone reverses oxymetazoline-induced tachyphylaxis of response and rebound congestion. Am J Respir Crit Care Med. 2010;182:19-24 pubmed publisher
    Chronic use of intranasal decongestants, such as oxymetazoline, leads to tachyphylaxis of response and rebound congestion, caused by alpha-adrenoceptor mediated down-regulation and desensitization of response...
  13. Li G, Zhang Y, Rodrigues E, Zheng D, Matheny M, Cheng K, et al. Melanocortin activation of nucleus of the solitary tract avoids anorectic tachyphylaxis and induces prolonged weight loss. Am J Physiol Endocrinol Metab. 2007;293:E252-8 pubmed
    ..in the NTS produces a characteristic unabated hypophagia that is uniquely different from the anorexic tachyphylaxis following POMC overexpression in the hypothalamus...
  14. Forooghian F, Cukras C, Meyerle C, Chew E, Wong W. Tachyphylaxis after intravitreal bevacizumab for exudative age-related macular degeneration. Retina. 2009;29:723-31 pubmed publisher
    To describe tachyphylaxis to intravitreal bevacizumab (IVB) in patients with exudative age-related macular degeneration (AMD)...
  15. Nauck M, Kemmeries G, Holst J, Meier J. Rapid tachyphylaxis of the glucagon-like peptide 1-induced deceleration of gastric emptying in humans. Diabetes. 2011;60:1561-5 pubmed publisher
    ..We addressed whether the GLP-1-induced deceleration of gastric emptying is subject to rapid tachyphylaxis and if so, how this would alter postprandial glucose control...
  16. Tsagaraki V, Amfilochiou A, Markantonis S. Evidence of tachyphylaxis associated with salmeterol treatment of chronic obstructive pulmonary disease patients. Int J Clin Pract. 2006;60:415-21 pubmed
    ..The aim of this study was to examine the development of tachyphylaxis to the long-acting beta2-agonist salmeterol using as a control therapeutic regimen the combination of ..
  17. Juan Fita M, Vargas M, Kaumann A, Hernández Cascales J. Rolipram reduces the inotropic tachyphylaxis of glucagon in rat ventricular myocardium. Naunyn Schmiedebergs Arch Pharmacol. 2004;370:324-9 pubmed
    ..Thus, PDE4 activity limits the responses mediated through both glucagon receptors and beta(1)-adrenoceptors. PDE4-catalysed hydrolysis of cAMP contributes to the inotropic tachyphylaxis of glucagon.
  18. Schaal S, Kaplan H, Tezel T. Is there tachyphylaxis to intravitreal anti-vascular endothelial growth factor pharmacotherapy in age-related macular degeneration?. Ophthalmology. 2008;115:2199-205 pubmed publisher
    ..Thus, multitargeted pharmacotherapy in exudative AMD may have a therapeutic benefit. Proprietary or commercial disclosure may be found after the references. ..
  19. Rivera L, Gallar J, Pozo M, Belmonte C. Responses of nerve fibres of the rat saphenous nerve neuroma to mechanical and chemical stimulation: an in vitro study. J Physiol. 2000;527 Pt 2:305-13 pubmed
    ..The 'inflammatory soup' evoked a firing response characterized by the absence of tachyphylaxis, which appeared when its components were applied separately...
  20. Read J, Boston R, Abraham G, Bauquier S, Soma L, Nolen Walston R. Effect of prolonged administration of clenbuterol on airway reactivity and sweating in horses with inflammatory airway disease. Am J Vet Res. 2012;73:140-5 pubmed publisher
    To determine whether prolonged administration of clenbuterol results in tachyphylaxis, specifically regarding its bronchoprotective properties and effect on sweating in horses. 8 Thoroughbreds with inflammatory airway disease...
  21. Dutertre S, Lumsden N, Alewood P, Lewis R. Isolation and characterisation of conomap-Vt, a D-amino acid containing excitatory peptide from the venom of a vermivorous cone snail. FEBS Lett. 2006;580:3860-6 pubmed
    ..Interestingly, the isomerization of L-Phe to D-Phe enhanced biological activity, suggesting that this post-translational modified conopeptide may have evolved for prey capture. ..
  22. Kłos K, Kruszewski J. [Does new antihistamines characterize tachyphylaxis phenomenon?]. Otolaryngol Pol. 2007;61:898-901 pubmed publisher
    ..001), remained at the same level all the time during the examination. Tachyphylaxis phenomenon for antihistamine effect of 10 mg/day cetirizine and 5 mg/day levocetirizine was not observed ..
  23. Peeters T. New motilin agonists: a long and winding road. Neurogastroenterol Motil. 2006;18:1-5 pubmed
  24. Liu L, Simon S. Similarities and differences in the currents activated by capsaicin, piperine, and zingerone in rat trigeminal ganglion cells. J Neurophysiol. 1996;76:1858-69 pubmed
    ..evoke many of the same physiological responses, but at comparable concentrations capsaicin produces complete tachyphylaxis, piperine produces partial tachyphylaxis, and zingerone can either induce or not induce tachyphylaxis...
  25. Kuzume K, Kuzume K, Cao Z, Liu L, Van Winkle D. Long-term infusion of Met5-enkephalin fails to protect murine hearts against ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2005;288:H1717-23 pubmed
    ..Furthermore, in this in vivo murine model, ME failed to induce delayed tolerance to myocardial ischemia-reperfusion. ..
  26. Huynh N, Harris E, Chin Dusting J, Andrews K. The vascular effects of different arginase inhibitors in rat isolated aorta and mesenteric arteries. Br J Pharmacol. 2009;156:84-93 pubmed publisher
    ..Many different inhibitors are used, and here we have examined the effects of these inhibitors on vascular tissue...
  27. Gu W, Yan H, Winters K, Komorowski R, Vonderfecht S, Atangan L, et al. Long-term inhibition of the glucagon receptor with a monoclonal antibody in mice causes sustained improvement in glycemic control, with reversible alpha-cell hyperplasia and hyperglucagonemia. J Pharmacol Exp Ther. 2009;331:871-81 pubmed publisher
    ..Our studies further support the concept that long-term inhibition of GCGR signaling by a mAb could be an effective approach for controlling diabetic hyperglycemia. ..
  28. Leamy A, Shukla P, McAlexander M, Carr M, Ghatta S. Curcumin ((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) activates and desensitizes the nociceptor ion channel TRPA1. Neurosci Lett. 2011;503:157-62 pubmed publisher
    ..curcumin-dependent currents in hTRPA1-HEK cells were completely desensitized and exhibited marked tachyphylaxis upon subsequent application of curcumin...
  29. Binder S. Loss of reactivity in intravitreal anti-VEGF therapy: tachyphylaxis or tolerance?. Br J Ophthalmol. 2012;96:1-2 pubmed publisher
  30. Cho D, Zheng M, Min C, Kwon K, Shin C, Choi H, et al. ARF6 and GASP-1 are post-endocytic sorting proteins selectively involved in the intracellular trafficking of dopamine D? receptors mediated by GRK and PKC in transfected cells. Br J Pharmacol. 2013;168:1355-74 pubmed publisher
    ..Distinct S/T residues within D? receptors and different sorting proteins are involved in the dissimilar regulation of D? receptors by GRK2 and PKC. ..
  31. Joseph E, Gear R, Levine J. Mechanical stimulation enhances endothelin-1 hyperalgesia. Neuroscience. 2011;178:189-95 pubmed publisher
  32. Ghatta S, Hemmer R, Uppala S, O Rourke S. Role of endogenous hydrogen peroxide in the development of nitrate tolerance. Vascul Pharmacol. 2007;46:247-52 pubmed
    ..SOD-mimetics may reduce nitrate tolerance, in part, by increasing the formation of hydrogen peroxide. ..
  33. Heatherley S, Hancock K, Rogers P. Psychostimulant and other effects of caffeine in 9- to 11-year-old children. J Child Psychol Psychiatry. 2006;47:135-42 pubmed
  34. Garzón J, López Fando A, Sánchez Blázquez P. The R7 subfamily of RGS proteins assists tachyphylaxis and acute tolerance at mu-opioid receptors. Neuropsychopharmacology. 2003;28:1983-90 pubmed
    ..Thus, R7 proteins play a critical role in agonist tachyphylaxis and acute tolerance at mu-opioid receptors, and show differences in their modulation of delta-opioid receptors. ..
  35. Brown D, Quito F. Neuromedin U octapeptide alters ion transport in porcine jejunum. Eur J Pharmacol. 1988;155:159-62 pubmed
    ..1 mumol/l), dependent upon extracellular Cl, and underwent tachyphylaxis upon repeated peptide application. NMU-8 did not affect contractility of isolated jejunal longitudinal muscle...
  36. Tomera K. Re: Long-term efficacy of sildenafil and tachyphylaxis effect. J Urol. 2002;168:206 pubmed
  37. Ladenheim E, Moore K, Salorio C, Mantey S, Taylor J, Coy D, et al. Characterization of bombesin binding sites in the rat stomach. Eur J Pharmacol. 1997;319:245-51 pubmed
    ..Furthermore, receptor tachyphylaxis to either neuromedin C or neuromedin B abolished the subsequent contractile response elicited by neuromedin C ..
  38. Liang Y, Haake B, Reeh P. Sustained sensitization and recruitment of rat cutaneous nociceptors by bradykinin and a novel theory of its excitatory action. J Physiol. 2001;532:229-39 pubmed
    ..be reproduced several times at equal magnitude, whereas the excitatory effect of BK regularly showed profound tachyphylaxis. Sustained superfusion (20 min) of BK induced a desensitizing excitatory response while superimposed heat ..
  39. Alhashemi J. Reduction of vasopressor requirement by hydrocortisone administration in a patient with cerebral vasospasm. Br J Anaesth. 2001;86:138-41 pubmed
    ..This tachyphylaxis to phenylephrine infusion was probably caused by down-regulation of alpha adrenoceptors, and was reversed by ..
  40. Graves J, Bates J, Kooy N, Lewis S. Vasodilator actions of the endothelium-derived relaxing factor L-S-nitrosocysteine in anaesthetized rats are markedly diminished by peroxynitrite. Clin Exp Pharmacol Physiol. 2005;32:1137-41 pubmed
    ..5-100 nmol/kg, i.v.) were determined in pentobarbital-anaesthetized rats before and after the induction of tachyphylaxis to peroxynitrite achieved by giving 10 intravenous injections of a 10 micromol/kg dose...
  41. Przyborski S, Levin R, Young A. Cumulative dose-response curves for bethanechol-induced electrogenic secretion in rat jejunum in vitro: is tachyphylaxis a significant factor?. Exp Physiol. 1991;76:293-6 pubmed
    ..Responses to consecutive additions of bethanechol (1 mM) to the serosal surface showed tachyphylaxis. Addition of prostaglandin E2, however, after a single dose of 1 mM-bethanechol, induced an undiminished Isc ..
  42. Tokumura A, Terao M, Okamoto M, Yoshida K, Tsukatani H. Study of platelet activating factor and its antagonists on rat colon strip with a new method avoiding tachyphylaxis. Eur J Pharmacol. 1988;148:353-60 pubmed
  43. Wolf E, Banerjee A, Soble Smith J, Dohan F, White R, Robertson J. Reversal of cerebral vasospasm using an intrathecally administered nitric oxide donor. J Neurosurg. 1998;89:279-88 pubmed
    ..dose of the drug was then given and serial arteriography continued for an additional hour to screen for tachyphylaxis. Intracranial pressure and respiratory and hemodynamic parameters were continuously monitored...
  44. Marchetti C, Nistri A. Neuronal bursting induced by NK3 receptor activation in the neonatal rat spinal cord in vitro. J Neurophysiol. 2001;86:2939-50 pubmed
    ..NK3 receptor activation could also facilitate fictive locomotor patterns induced by NMDA and 5-HT...
  45. Gao Y, Lee R. Hydrogen peroxide induces a greater contraction in mesenteric arteries of spontaneously hypertensive rats through thromboxane A(2) production. Br J Pharmacol. 2001;134:1639-46 pubmed
    ..Removal of endothelium potentiated the contraction to H(2)O(2) in WKY but not in SHR. Tachyphylaxis to H(2)O(2) was less prominent in SHR than in WKY. 3...
  46. Gu Z, Ling Y, Li S, Meng A, Zhang J. [Properties of peroxynitrite-induced relaxation in rabbit pulmonary artery in vitro]. Sheng Li Xue Bao. 2001;53:307-10 pubmed
    ..These results suggest that ONOO(-) causes weak relaxation in pulmonary artery, which is down regulated by endothelium and is of tachyphylaxis.
  47. França L, Correa S, Barbosa A, Ferreira A, Han S, Shimuta S, et al. Evidence for changes in the tachyphylactic property of recombinant angiotensin II AT(1) receptor expressed in CHO cells. Eur J Pharmacol. 2002;439:13-9 pubmed
    The manifestation of tachyphylaxis to angiotensin II in Chinese hamster ovary (CHO) cells expressing the rat angiotensin II AT(1) receptor was investigated...
  48. Herzyk D, Soos J, Maier C, Gore E, Narayanan P, Nadwodny K, et al. Immunopharmacology of recombinant human interleukin-18 in non-human primates. Cytokine. 2002;20:38-48 pubmed
    ..The described pharmacological profile of rHuIL-18 in both cynomolgus monkeys and chimpanzees is indicative of the immunotherapeutic potential of rHuIL-18 in the treatment of cancer. ..
  49. Humm K, Senior J, Dugdale A, Summerfield N. Use of sodium nitroprusside in the anaesthetic protocol of a patent ductus arteriosus ligation in a dog. Vet J. 2007;173:194-6 pubmed
    ..It is speculated that the lack of response may have been due to tachyphylaxis. Other drugs may be preferred to induce deliberate hypotension in the dog.
  50. Barros A, Ito C, Makino E, Cembranelli F, Moraes F, Souza S, et al. Factors regulating tachyphylaxis triggered by N-terminal-modified angiotensin II analogs. Biol Chem. 2009;390:1265-70 pubmed publisher
    Binding of angiotensin II (DRVYIHPF, AngII) to its AT(1) receptor can trigger a process known as tachyphylaxis (loss of receptor response owing to repeated agonist stimulation)...
  51. Choi R, Birknes J, Popitz Bergez F, Kissin I, Strichartz G. Pharmacokinetic nature of tachyphylaxis to lidocaine: peripheral nerve blocks and infiltration anesthesia in rats. Life Sci. 1997;61:PL 177-84 pubmed
    b>Tachyphylaxis to peripheral neural blockade was determined with repeated injections of a constant dose of lidocaine in three experimental models: sciatic nerve block, produced by intraneural or extraneural injections, and infiltration ..
  52. Harada K, Ohmori M, Fujimura A. Vasoconstricting effect of angiotensin II in human hand veins: influence of aging, diabetes mellitus and hypertension. Hypertens Res. 2002;25:683-8 pubmed
    ..The constant infusion of Ang II caused rapid desensitization or tachyphylaxis. The venoconstriction by Ang II in the 8 elderly subjects (58 to 73 years) was significantly (p<0...
  53. Cardell L, Uddman R, Edvinsson L. Evidence for multiple endothelin receptors in the guinea-pig pulmonary artery and trachea. Br J Pharmacol. 1992;105:376-80 pubmed
    ..There was no evidence for additivity and only a slight tendency to tachyphylaxis was seen. 4...