latex hypersensitivity

Summary

Summary: Allergic reaction to products containing processed natural rubber latex such as rubber gloves, condoms, catheters, dental dams, balloons, and sporting equipment. Both T-cell mediated (HYPERSENSITIVITY, DELAYED) and IgE antibody-mediated (HYPERSENSITIVITY, IMMEDIATE) allergic responses are possible. Delayed hypersensitivity results from exposure to antioxidants present in the rubber; immediate hypersensitivity results from exposure to a latex protein.

Top Publications

  1. Korniewicz D, Chookaew N, El Masri M, Mudd K, Bollinger M. Conversion to low-protein, powder-free surgical gloves: is it worth the cost?. AAOHN J. 2005;53:388-93 pubmed
    ..This study demonstrated that conversion to the use of powder-free, low-protein NRL gloves not only reduces health care worker NRL symptoms, but also positively affects the costs of glove purchases and workers' compensation...
  2. Al Otaibi S, Tarlo S, House R. Quality of life in patients with latex allergy. Occup Med (Lond). 2005;55:88-92 pubmed
    ..Exposure to natural rubber latex (NRL) may lead to a variety of allergic clinical manifestations that may affect the quality of life (QOL)...
  3. Smith A, Amin H, Biagini R, Hamilton R, Arif S, Yeang H, et al. Percutaneous reactivity to natural rubber latex proteins persists in health-care workers following avoidance of natural rubber latex. Clin Exp Allergy. 2007;37:1349-56 pubmed
    ..Percutaneous sensitivity to eight Hev b NRL allergens was evaluated in HCWs in 2000. To date, no studies have evaluated the longitudinal effects of NRL avoidance on percutaneous sensitivity to NRL allergens...
  4. Karisola P, Kotovuori A, Poikonen S, Niskanen E, Kalkkinen N, Turjanmaa K, et al. Isolated hevein-like domains, but not 31-kd endochitinases, are responsible for IgE-mediated in vitro and in vivo reactions in latex-fruit syndrome. J Allergy Clin Immunol. 2005;115:598-605 pubmed
    ..IgE of these patients has been shown to bind endochitinases containing an N-terminal hevein-like domain (HLD). However, evidence on 31-kd endochitinase-induced reactions in vivo is lacking...
  5. Ebo D, Hagendorens M, De Knop K, Verweij M, Bridts C, De Clerck L, et al. Component-resolved diagnosis from latex allergy by microarray. Clin Exp Allergy. 2010;40:348-58 pubmed publisher
    ..A positive specific IgE (sIgE) result for latex does not always mirror the clinical situation and is frequently found in individuals without overt latex allergy...
  6. Untersmayr E, Lukschal A, Hemmer W, Harwanegg C, Breiteneder H, Jarisch R, et al. Exercise with latex sport bands represents a risk for latex allergic patients. Immunol Lett. 2008;115:98-104 pubmed
    ..Even though latex is labeled on products, it is important that patients as well as athletic trainers and physical therapists recognize the risk of adverse reactions with these bands...
  7. Raulf Heimsoth M, Kespohl S, Crespo J, Rodriguez J, Feliu A, Brüning T, et al. Natural rubber latex and chestnut allergy: cross-reactivity or co-sensitization?. Allergy. 2007;62:1277-81 pubmed
    ..Chestnut and natural rubber latex (NRL) allergy are often associated in the latex-fruit syndrome...
  8. Palomares O, Villalba M, Quiralte J, Polo F, Rodriguez R. 1,3-beta-glucanases as candidates in latex-pollen-vegetable food cross-reactivity. Clin Exp Allergy. 2005;35:345-51 pubmed
    ..1,3-beta-glucanases (group 2 of pathogenesis-related proteins) are enzymes widely distributed among higher plants and have been recently proven to be significant allergens...
  9. Suli C, Lorini M, Mistrello G, Tedeschi A. Diagnosis of latex hypersensitivity: comparison of different methods. Eur Ann Allergy Clin Immunol. 2006;38:24-30 pubmed
    ..Patch testing with rubber chemicals should be reserved to selected cases. Basophil histamine release and immunoblotting can be performed for research purpose, but cannot be recommended for routine diagnostic use...

More Information

Publications62

  1. Sanz M, García Avilés M, Tabar A, Anda M, Garcia B, Barber D, et al. Basophil Activation Test and specific IgE measurements using a panel of recombinant natural rubber latex allergens to determine the latex allergen sensitization profile in children. Pediatr Allergy Immunol. 2006;17:148-56 pubmed
    ..BAT and allergen-specific IgE determination could be used as first-line in vitro diagnostic tests in patients with NRL allergy...
  2. Bousquet J, Flahault A, Vandenplas O, Ameille J, Duron J, Pecquet C, et al. Natural rubber latex allergy among health care workers: a systematic review of the evidence. J Allergy Clin Immunol. 2006;118:447-54 pubmed
    ..Natural rubber latex is a recognized allergen, but a recent meta-analysis failed to find any association between latex exposure and allergy in health care workers (HCWs)...
  3. Wagner S, Radauer C, Hafner C, Fuchs H, Jensen Jarolim E, Wuthrich B, et al. Characterization of cross-reactive bell pepper allergens involved in the latex-fruit syndrome. Clin Exp Allergy. 2004;34:1739-46 pubmed
    ..Simultaneous sensitization to latex and bell pepper has been previously reported. Although bell pepper fruits are frequently consumed raw, cooked or as a spice, little is known about the cross-reactive allergens...
  4. Filon F, Radman G. Latex allergy: a follow up study of 1040 healthcare workers. Occup Environ Med. 2006;63:121-5 pubmed
  5. Demaegd J, Soetens F, Herregods L. Latex allergy: a challenge for anaesthetists. Acta Anaesthesiol Belg. 2006;57:127-35 pubmed
    ..In the future, desensitization will probably be useful in helping patients with latex allergy...
  6. Cremer R, Lorbacher M, Hering F, Engelskirchen R. Natural rubber latex sensitisation and allergy in patients with spina bifida, urogenital disorders and oesophageal atresia compared with a normal paediatric population. Eur J Pediatr Surg. 2007;17:194-8 pubmed
    ..In this setting the influence of surgery and anaesthesia on NRL-sensitisation was investigated...
  7. Yeang H, Hamilton R, Bernstein D, Arif S, Chow K, Loke Y, et al. Allergen concentration in natural rubber latex. Clin Exp Allergy. 2006;36:1078-86 pubmed
    ..Hevea brasiliensis latex serum is commonly used as the in vivo and in vitro reference antigen for latex allergy diagnosis as it contains the full complement of latex allergens...
  8. Nienhaus A, Kromark K, Raulf Heimsoth M, van Kampen V, Merget R. Outcome of occupational latex allergy--work ability and quality of life. PLoS ONE. 2008;3:e3459 pubmed publisher
    ..The quality of life (QOL) and work ability of health care workers allergic to natural rubber latex (NRL) were assessed after implementation of regulations on powder-free NRL gloves in Germany...
  9. Mari A, Scala E, D Ambrosio C, Breiteneder H, Wagner S. Latex allergy within a cohort of not-at-risk subjects with respiratory symptoms: prevalence of latex sensitization and assessment of diagnostic tools. Int Arch Allergy Immunol. 2007;143:135-43 pubmed
    ..Many cases of NRL allergy remain undiagnosed due to misreporting of symptoms by the patients or lack of proper questions asked by the physician...
  10. Nettis E, Colanardi M, Soccio A, Marcandrea M, Pinto L, Ferrannini A, et al. Double-blind, placebo-controlled study of sublingual immunotherapy in patients with latex-induced urticaria: a 12-month study. Br J Dermatol. 2007;156:674-81 pubmed
    ..Natural rubber latex (NRL) allergy is a worldwide problem. Although prevention is sufficient to reduce sensitization, prolonged avoidance is needed to prevent resensitization or adverse reactions on re-exposure...
  11. Latza U, Haamann F, Baur X. Effectiveness of a nationwide interdisciplinary preventive programme for latex allergy. Int Arch Occup Environ Health. 2005;78:394-402 pubmed
  12. Lewis V, Chowdhury M, Statham B. Natural rubber latex allergy: the impact on lifestyle and quality of life. Contact Dermatitis. 2004;51:317-8 pubmed
  13. Kean T, McNally M. Latex hypersensitivity: a closer look at considerations for dentistry. J Can Dent Assoc. 2009;75:279-82 pubmed
    Over the past several decades, latex hypersensitivity has become an increasingly common phenomenon in the dental setting...
  14. Pedraza Escalona M, Becerril Luján B, Agundis C, Dominguez Ramirez L, Pereyra A, Riaño Umbarila L, et al. Analysis of B-cell epitopes from the allergen Hev b 6.02 revealed by using blocking antibodies. Mol Immunol. 2009;46:668-76 pubmed publisher
    ..02-IgE interactions. Antibodies recognizing this important allergen have potential to be used to diagnose and ultimately treat latex allergy...
  15. Rolland J, O Hehir R. Latex allergy: a model for therapy. Clin Exp Allergy. 2008;38:898-912 pubmed publisher
    ..The co-administration of adjunct therapies such as anti-IgE or corticosteroids and of appropriate adjuvants for induction of regulatory T cell response offers promise for clinically effective, safe latex-specific vaccines...
  16. Barre A, Culerrier R, Granier C, Selman L, Peumans W, Van Damme E, et al. Mapping of IgE-binding epitopes on the major latex allergen Hev b 2 and the cross-reacting 1,3beta-glucanase fruit allergens as a molecular basis for the latex-fruit syndrome. Mol Immunol. 2009;46:1595-604 pubmed publisher
    ..Additionally, surface-exposed regions with a very close conformation were predicted to occur on Ole e 9, the 1,3beta-glucanase allergen identified in olive pollen...
  17. Buyukozturk S, Gelincik A, Ozseker F, Colakoglu B, Dal M. Latex sublingual immunotherapy: can its safety be predicted?. Ann Allergy Asthma Immunol. 2010;104:339-42 pubmed publisher
    ..Complete avoidance sometimes cannot be possible in latex-allergic health care workers. So far, very few double-blind placebo-controlled studies revealed the efficacy of sublingual latex immunotherapy (SLIT) in those patients...
  18. Wagner S, Breiteneder H. Hevea brasiliensis latex allergens: current panel and clinical relevance. Int Arch Allergy Immunol. 2005;136:90-7 pubmed
    ..In this review, we summarize current knowledge on the immunological properties of the 13 officially accepted Hevea brasiliensis latex allergens...
  19. Rueff F, Schöpf P, Putz K, Przybilla B. Effect of reduced exposure on natural rubber latex sensitization in health care workers. Ann Allergy Asthma Immunol. 2004;92:530-7 pubmed
    ..Knowledge about the long-term course of allergy or sensitization to natural rubber latex (NRL) is insufficient...
  20. Hemery M, Dhivert Donnadieu H, Verdier R, Dujols P, Godard P, Demoly P. A clinical and serological follow-up study of health care workers allergic to natural rubber latex who had followed a latex avoidance programme. Allergy. 2004;59:1013-4 pubmed
  21. O Riordain G, Radauer C, Hoffmann Sommergruber K, Adhami F, Peterbauer C, Blanco C, et al. Cloning and molecular characterization of the Hevea brasiliensis allergen Hev b 11, a class I chitinase. Clin Exp Allergy. 2002;32:455-62 pubmed
    ..Class I chitinases have been identified from chestnut, avocado and banana as relevant allergens. The chitin binding (hevein) domain from these class I chitinases has been postulated to bear the important IgE binding epitopes...
  22. Bernstein D, Karnani R, Biagini R, Bernstein C, Murphy K, Berendts B, et al. Clinical and occupational outcomes in health care workers with natural rubber latex allergy. Ann Allergy Asthma Immunol. 2003;90:209-13 pubmed
    ..There is limited information pertaining to clinical outcomes and economic consequences of natural rubber latex (NRL) allergy in health care workers (HCWs)...
  23. Bernstein D, Biagini R, Karnani R, Hamilton R, Murphy K, Bernstein C, et al. In vivo sensitization to purified Hevea brasiliensis proteins in health care workers sensitized to natural rubber latex. J Allergy Clin Immunol. 2003;111:610-6 pubmed
    ..However, the in vivo importance of native Hev b allergens has not been defined in health care workers (HCWs) with natural rubber latex (NRL) allergy...
  24. Horwitz I, Arvey R. Workers' compensation claims from latex glove use: a longitudinal analysis of Minnesota data from 1988 to 1997. J Occup Environ Med. 2000;42:932-8 pubmed
    ..Using empirical cost data from another study, it was found that it is not cost-beneficial for health care institutions to globally adopt latex glove-free policies solely on the basis of workers' compensation costs...
  25. Ganglberger E, Radauer C, Wagner S, R ord in G, Beezhold D, Brehler R, et al. Hev b 8, the Hevea brasiliensis latex profilin, is a cross-reactive allergen of latex, plant foods and pollen. Int Arch Allergy Immunol. 2001;125:216-27 pubmed publisher
    ..Additionally, pollinosis and food-allergic patients with profilin-specific IgE can be at risk of developing latex allergy...
  26. Laxenaire M, Mertes P. Anaphylaxis during anaesthesia. Results of a two-year survey in France. Br J Anaesth. 2001;87:549-58 pubmed
    ..These results are consistent with changes in the epidemiology of anaphylaxis related to anaesthesia and are an incentive for the further development of allergo-anaesthesia clinical networks...
  27. Edelstam G, Arvanius L, Karlsson G. Glove powder in the hospital environment -- consequences for healthcare workers. Int Arch Occup Environ Health. 2002;75:267-71 pubmed
    ..To evaluate and take care of this problem at Stockholm Söder Hospital we carried out this study...
  28. Allmers H, Schmengler J, Skudlik C. Primary prevention of natural rubber latex allergy in the German health care system through education and intervention. J Allergy Clin Immunol. 2002;110:318-23 pubmed
    ..There are few published studies to suggest that intervention programs to reduce exposure will lead to primary prevention of sensitization...
  29. Patriarca G, Nucera E, Pollastrini E, Roncallo C, Buonomo A, Bartolozzi F, et al. Sublingual desensitization: a new approach to latex allergy problem. Anesth Analg. 2002;95:956-60, table of contents pubmed
    ..All the desensitized patients can now wear latex gloves and undergo medical procedures without any symptoms...
  30. Wagner S, Breiteneder H. The latex-fruit syndrome. Biochem Soc Trans. 2002;30:935-40 pubmed
    ..Although there is much information about the plant-derived foods and some data about the allergens involved in the latex-fruit syndrome, it is not always clear whether latex sensitization precedes or follows the onset of food allergy...
  31. Beezhold D, Hickey V, Kostyal D, Puhl H, Zuidmeer L, van Ree R, et al. Lipid transfer protein from Hevea brasiliensis (Hev b 12), a cross-reactive latex protein. Ann Allergy Asthma Immunol. 2003;90:439-45 pubmed
    ..We sought to determine whether Hevea brasiliensis produces LTP and whether it would bind immunoglobulin E from latex-allergic patients...
  32. Ahmed D, Sobczak S, Yunginger J. Occupational allergies caused by latex. Immunol Allergy Clin North Am. 2003;23:205-19 pubmed
    ..Optimal management of latex allergy involves education concerning cross-reacting allergens, reduction of cutaneous or mucosal contact with dipped rubber products, and minimization of exposure to latex aeroallergens in work environments...
  33. Reyes López C, Hernandez Santoyo A, Pedraza Escalona M, Mendoza G, Hernández Arana A, Rodriguez Romero A. Insights into a conformational epitope of Hev b 6.02 (hevein). Biochem Biophys Res Commun. 2004;314:123-30 pubmed
    ..Overall our results indicate that the central part of the protein, which comprises three aromatic and other acidic and polar residues, constitutes a conformational epitope...
  34. Shivkar Y, Kumar V. Histamine mediates the pro-inflammatory effect of latex of Calotropis procera in rats. Mediators Inflamm. 2003;12:299-302 pubmed
    ..In present study we have pharmacologically characterized the inflammation induced by latex of C. procera in a rat paw edema model and determined the role of histamine in latex-induced inflammation...
  35. Cistero Bahima A, Sastre J, Enrique E, Fernandez M, Alonso R, Quirce S, et al. Tolerance and effects on skin reactivity to latex of sublingual rush immunotherapy with a latex extract. J Investig Allergol Clin Immunol. 2004;14:17-25 pubmed
    ..Specific immunotherapy could be a therapeutic tool for the increasing problem of sensitisation to Natural Rubber Latex (NRL)...
  36. Allmers H, Schmengler J, John S. Decreasing incidence of occupational contact urticaria caused by natural rubber latex allergy in German health care workers. J Allergy Clin Immunol. 2004;114:347-51 pubmed
    ..The development of allergy to natural rubber latex (NRL) is a risk for health care workers. A regulation banning powdered NRL gloves was implemented in Germany in 1998...
  37. Sastre J, Fernández Nieto M, Rico P, Martin S, Barber D, Cuesta J, et al. Specific immunotherapy with a standardized latex extract in allergic workers: a double-blind, placebo-controlled study. J Allergy Clin Immunol. 2003;111:985-94 pubmed
    ..Preventive measures have been proposed to reduce the risk of sensitization to natural rubber latex (NRL), but this is not always feasible...
  38. Schmidt M, Raulf Heimsoth M, Posch A. Evaluation of patatin as a major cross-reactive allergen in latex-induced potato allergy. Ann Allergy Asthma Immunol. 2002;89:613-8 pubmed
    ..This study was designed to investigate the molecular basis of acquired food sensitization focusing on the storage protein patatin and the patatin-like latex protein Hev b 7...
  39. Ownby D. Strategies for distinguishing asymptomatic latex sensitization from true occupational allergy or asthma. Ann Allergy Asthma Immunol. 2003;90:42-6 pubmed
    ..To evaluate strategies for distinguishing those individuals with true occupational asthma caused by exposure to natural rubber latex from those individuals with allergic disease related to other allergens...
  40. Mertes P, Laxenaire M, Alla F. Anaphylactic and anaphylactoid reactions occurring during anesthesia in France in 1999-2000. Anesthesiology. 2003;99:536-45 pubmed
    ..Anaphylactic and anaphylactoid reactions occurring during anesthesia remain a major cause of concern for anesthesiologists. The authors report the results of a 2-yr survey of such reactions observed during anesthesia in France...
  41. Karisola P, Mikkola J, Kalkkinen N, Airenne K, Laitinen O, Repo S, et al. Construction of hevein (Hev b 6.02) with reduced allergenicity for immunotherapy of latex allergy by comutation of six amino acid residues on the conformational IgE epitopes. J Immunol. 2004;172:2621-8 pubmed
    ..Hevein with a highly reduced ability to bind IgE should provide a valuable candidate molecule for immunotherapy of latex allergy and is anticipated to have a low risk of systemic side effects...
  42. Saary M, Kanani A, Alghadeer H, Holness D, Tarlo S. Changes in rates of natural rubber latex sensitivity among dental school students and staff members after changes in latex gloves. J Allergy Clin Immunol. 2002;109:131-5 pubmed
    ..A high rate of sensitization and clinical allergy to natural rubber latex (NRL) gloves has been reported in dental students and staff members...
  43. Mikkola J, Alenius H, Kalkkinen N, Turjanmaa K, Palosuo T, Reunala T. Hevein-like protein domains as a possible cause for allergen cross-reactivity between latex and banana. J Allergy Clin Immunol. 1998;102:1005-12 pubmed
    ..Patients allergic to natural rubber latex (NRL) frequently exhibit immediate hypersensitivity reactions to banana, but the molecular basis of these putative cross-reactions is unknown...
  44. Phillips V, Goodrich M, Sullivan T. Health care worker disability due to latex allergy and asthma: a cost analysis. Am J Public Health. 1999;89:1024-8 pubmed
  45. Nettis E, Dambra P, Soccio A, Ferrannini A, Tursi A. Latex hypersensitivity: relationship with positive prick test and patch test responses among hairdressers. Allergy. 2003;58:57-61 pubmed
    ..Natural rubber latex is a frequent cause of IgE-mediated allergy in hairdressers; but a non-IgE-mediated allergy to latex proteins can also occur. Sixty-one hairdressers, reporting latex glove-related symptoms, were enrolled in the study...
  46. Blanco C. Latex-fruit syndrome. Curr Allergy Asthma Rep. 2003;3:47-53 pubmed
    ..This review focuses on our current understanding of the latex-fruit syndrome...
  47. Horwitz I, Kammeyer Mueller J, McCall B. Assessing latex allergy among health care employees using workers' compensation data. Minn Med. 2001;84:47-50 pubmed
    ..08 per health care worker. Skin disorders were the most commonly reported condition. These findings are compared with previous studies of Minnesota and Rhode Island and demonstrate similar results...
  48. Ogata J, Minami K. Synthetic oxytocin and latex allergy. Br J Anaesth. 2007;98:845-6 pubmed
  49. Dougall A, Fiske J. Access to special care dentistry, part 5. Safety. Br Dent J. 2008;205:177-90 pubmed publisher
  50. Hain M, Longman L, Field E, Harrison J. Natural rubber latex allergy: implications for the orthodontist. J Orthod. 2007;34:6-11 pubmed
    ..Safe and effective practice depends on recognizing patients who are at risk of NRL allergy, and an awareness of materials and equipment that contain NRL and the availability of suitable NRL-free alternatives...
  51. Ventura M, Musi M, Giuliano G, Arsieni A, Di Leo E, Buquicchio R, et al. Latex allergy and sensitization in cities: a survey in a population at risk. Int J Immunopathol Pharmacol. 2006;19:821-30 pubmed
  52. Yazicioglu M, Oner N, Celtik C, Okutan O, Pala O. Sensitization to common allergens, especially pollens, among children with respiratory allergy in the Trakya region of Turkey. Asian Pac J Allergy Immunol. 2004;22:183-90 pubmed
    ..Although Trakya is close to Greece and other Mediterranean countries, this study suggests that the pollens, which sensitize children, are not similar...
  53. Sekiya K, Watai K, Taniguchi M, Mitsui C, Fukutomi Y, Tanimoto H, et al. Latex anaphylaxis caused by a Swan-Ganz catheter. Intern Med. 2011;50:355-7 pubmed
    ..Anaphylactic shock caused by the latex balloon of a Swan-Ganz catheter was diagnosed. It is necessary to pay attention to not only latex allergy but also fruit allergies with a cross-reactivity to latex...