arthus reaction


Summary: A dermal inflammatory reaction produced under conditions of antibody excess, when a second injection of antigen produces intravascular antigen-antibody complexes which bind complement, causing cell clumping, endothelial damage, and vascular necrosis.

Top Publications

  1. Kubo K, Kita T, Tsujimura T, Nakashima T. Effect of nicotine-induced corticosterone elevation on nitric oxide production in the passive skin arthus reaction in rats. J Pharmacol Sci. 2004;94:31-8 pubmed
    To elucidate the anti-inflammatory action of nicotine-induced corticosterone elevation on the passive skin Arthus reaction (PSAR), we investigated the inflammatory process in the PSAR...
  2. Ishii T, Fujita T, Matsushita T, Yanaba K, Hasegawa M, Nakashima H, et al. Establishment of experimental eosinophilic vasculitis by IgE-mediated cutaneous reverse passive arthus reaction. Am J Pathol. 2009;174:2225-33 pubmed publisher, we established a mouse model of cutaneous eosinophilic vasculitis by the cutaneous reverse passive Arthus reaction using IgE injection instead of IgG...
  3. Hazenbos W, Gessner J, Hofhuis F, Kuipers H, Meyer D, Heijnen I, et al. Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice. Immunity. 1996;5:181-8 pubmed
    ..cell degranulation, are resistant to IgG-dependent passive cutaneous anaphylaxis, and exhibit an impaired Arthus reaction. These results indicate a prominent role for Fc gamma RIII in inflammatory and anaphylactic responses, making ..
  4. Jappe U, Reinhold D, Bonnekoh B. Arthus reaction to lepirudin, a new recombinant hirudin, and delayed-type hypersensitivity to several heparins and heparinoids, with tolerance to its intravenous administration. Contact Dermatitis. 2002;46:29-32 pubmed
    ..After subcutaneous challenge with the recombinant hirudin lepirudin (Refludan) the patient developed a local Arthus reaction at the injection site...
  5. Paiva C, Arras R, Magalhães E, Alves L, Lessa L, Silva M, et al. Migration inhibitory factor (MIF) released by macrophages upon recognition of immune complexes is critical to inflammation in Arthus reaction. J Leukoc Biol. 2009;85:855-61 pubmed publisher
    ..Using passive reverse Arthus reaction in the peritoneum and lungs as a model for IC-induced inflammation, we demonstrated that Mif-/- mice had a ..
  6. Strachan A, Woodruff T, Haaima G, Fairlie D, Taylor S. A new small molecule C5a receptor antagonist inhibits the reverse-passive Arthus reaction and endotoxic shock in rats. J Immunol. 2000;164:6560-5 pubmed
    ..and LPS-induced neutrophil adhesion and cytokine expression, as well as against some hallmarks of the reverse Arthus reaction in rats. We found that a single i.v...
  7. Carbo C, Yuki K, Demers M, Wagner D, Shimaoka M. Isoflurane inhibits neutrophil recruitment in the cutaneous Arthus reaction model. J Anesth. 2013;27:261-8 pubmed publisher
    ..2 integrins is variable in different tissues, but has not yet been verified in the cutaneous passive reverse Arthus reaction. We examined this question and also evaluated the impact of isoflurane on neutrophil recruitment to the skin ..
  8. Kohl J, Gessner J. On the role of complement and Fc gamma-receptors in the Arthus reaction. Mol Immunol. 1999;36:893-903 pubmed
    ..receptor type I for IgE (IgepsilonRI), showed an impaired inflammatory response in the reverse passive Arthus reaction in skin, peritoneum and lung...
  9. Boughton Smith N, Deakin A, Follenfant R, Whittle B, Garland L. Role of oxygen radicals and arachidonic acid metabolites in the reverse passive Arthus reaction and carrageenin paw oedema in the rat. Br J Pharmacol. 1993;110:896-902 pubmed
    ..acid metabolites and oxygen radicals in carrageenin-induced rat paw oedema and dermal reverse passive Arthus reaction (RPA) have been investigated. 2. Indomethacin (10 mg kg-1, p.o...

More Information


  1. Chen T, Guo Z, Wang L, Qin S, Cao N, Li M, et al. Paeoniflorin suppresses vascular damage and the expression of E-selectin and ICAM-1 in a mouse model of cutaneous Arthus reaction. Exp Dermatol. 2013;22:453-7 pubmed publisher
    ..Herein, we investigate the effects of PF on adhesion molecule expression in a mouse model of cutaneous Arthus reaction and cultured human dermal microvascular endothelial cells (HDMECs)...
  2. Skokowa J, Ali S, Felda O, Kumar V, Konrad S, Shushakova N, et al. Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation. J Immunol. 2005;174:3041-50 pubmed
    ..In this study we show that in the lung Arthus reaction, the initial contact between immune complexes and alveolar macrophages (AM) results in plasma complement-..
  3. Shashidharamurthy R, Hennigar R, Fuchs S, Palaniswami P, Sherman M, Selvaraj P. Extravasations and emigration of neutrophils to the inflammatory site depend on the interaction of immune-complex with Fcgamma receptors and can be effectively blocked by decoy Fcgamma receptors. Blood. 2008;111:894-904 pubmed
    ..blocked IC-induced inflammation, mast- cell degranulation, and extravasation of neutrophils in a reversed Arthus reaction. Although the binding of CD16A-Ig to IC did not alter the complement-activating properties of IC, no evidence ..
  4. Hara T, Shimizu K, Ogawa F, Yanaba K, Iwata Y, Muroi E, et al. Platelets control leukocyte recruitment in a murine model of cutaneous arthus reaction. Am J Pathol. 2010;176:259-69 pubmed publisher
    Platelets have been shown to be important in inflammation, but their role in the cutaneous Arthus reaction remains unclear...
  5. Sylvestre D, Ravetch J. A dominant role for mast cell Fc receptors in the Arthus reaction. Immunity. 1996;5:387-90 pubmed
    ..recently demonstrated that experimental immune complex-mediated injury in mice, as modeled by the cutaneous Arthus reaction, requires receptors for the Fc portion of the antibody and is unaffected by deficiencies in complement ..
  6. Höpken U, Lu B, Gerard N, Gerard C. Impaired inflammatory responses in the reverse arthus reaction through genetic deletion of the C5a receptor. J Exp Med. 1997;186:749-56 pubmed
    ..of neutrophils and decreased levels of TNF-alpha and interleukin 6 in the peritoneal reverse passive Arthus reaction compared to their wild-type littermates...
  7. Szalai A, Digerness S, Agrawal A, Kearney J, Bucy R, Niwas S, et al. The Arthus reaction in rodents: species-specific requirement of complement. J Immunol. 2000;164:463-8 pubmed
    ..These data support the proposal that complement-mediated processes are of major importance in the Arthus reaction in rats and guinea pigs, and suggest that BCX 1470 will be useful as an anti-inflammatory agent in diseases ..
  8. Baumann U, Kohl J, Tschernig T, Schwerter Strumpf K, Verbeek J, Schmidt R, et al. A codominant role of Fc gamma RI/III and C5aR in the reverse Arthus reaction. J Immunol. 2000;164:1065-70 pubmed
    ..Therefore, FcgammaR-mediated responses can be integrated through C5aR activation, which may explain why these two receptor pathways have previously been considered to dominate each other...
  9. Teixeira M, Fairbairn S, Norman K, Williams T, Rossi A, Hellewell P. Studies on the mechanisms involved in the inflammatory response in a reversed passive Arthus reaction in guinea-pig skin: contribution of neutrophils and endogenous mediators. Br J Pharmacol. 1994;113:1363-71 pubmed
    ..Moreover, our results confirm previous findings which suggest a dominant role for nitric oxide in maintaining cutaneous blood flow in the guinea-pig...
  10. Ravetch J, Bolland S. IgG Fc receptors. Annu Rev Immunol. 2001;19:275-90 pubmed
    ..Fc gamma Rs offer a paradigm for the biological significance of balancing activation and inhibitory signaling in the expanding family of activation/inhibitory receptor pairs found in the immune system...
  11. Ozaki N, Ishizaki M, Ghazizadeh M, Yamanaka N. Apoptosis mediates decrease in cellularity during the regression of Arthus reaction in cornea. Br J Ophthalmol. 2001;85:613-8 pubmed
    ..The aim was to establish whether apoptosis affected the regression of inflammatory cells and newly formed microvessels, in order to define more clearly the cellular mechanisms involved in the pathobiology of corneal diseases...
  12. Kaburagi Y, Hasegawa M, Nagaoka T, Shimada Y, Hamaguchi Y, Komura K, et al. The cutaneous reverse Arthus reaction requires intercellular adhesion molecule 1 and L-selectin expression. J Immunol. 2002;168:2970-8 pubmed
    ..To assess the role of L-selectin and ICAM-1 in this pathogenetic process, the cutaneous reverse passive Arthus reaction was examined in mice lacking L-selectin (L-selectin(-/-)), ICAM-1 (ICAM-1(-/-)), or both (L-selectin/ICAM-1(-/..
  13. Kirkpatrick C, Farrell J. Leishmaniasis in beige mice. Infect Immun. 1982;38:1208-16 pubmed
    ..donovani antigen. The results of this study suggest a possible role for natural killer cells in recovery from L. donovani but not from L. tropica infection...
  14. Moore A. Pleural models of inflammation: immune and nonimmune. Methods Mol Biol. 2003;225:123-8 pubmed
  15. Kikuchi S, Takehana Y, Hamano S, Ichikawa K, Komatsu H, Okegawa T, et al. [Anti-allergic effects of (E)-3-[p-(1H-imidazol-1-ylmethyl)phenyl]-2-propenoic acid (OKY-046), a specific thromboxane (TX) A2 synthetase inhibitor: effect of OKY-046 on II-IV type allergic reactions]. Nihon Yakurigaku Zasshi. 1990;95:131-7 pubmed
    ..In Type III, OKY-046 (300 mg/kg, p.o.) significantly suppressed the direct passive Arthus reaction and immune complex nephritis in rats...
  16. Smith S, Watnick A, Bryant R, Billah M, Siegel M. Actions of a 5-lipoxygenase inhibitor, Sch 40120, on acute inflammatory responses. J Pharmacol Exp Ther. 1992;262:721-8 pubmed
    ..The drug suppressed paw inflammation triggered by a reverse passive Arthus reaction or a subplantar injection of the polysaccharide carrageenan with p.o. ED50 values of 0.2 and 1...
  17. Yanaba K, Mukaida N, Matsushima K, Murphy P, Takehara K, Sato S. Role of C-C chemokine receptors 1 and 5 and CCL3/macrophage inflammatory protein-1alpha in the cutaneous Arthus reaction: possible attenuation of their inhibitory effects by compensatory chemokine production. Eur J Immunol. 2004;34:3553-61 pubmed
    ..CCL3/macrophage inflammatory protein-1alpha, in this pathogenic process, the reverse passive cutaneous Arthus reaction was induced in mice lacking CCR1, CCR5, or CCL3...
  18. Shimizu K, Ogawa F, Hara T, Yoshizaki A, Muroi E, Yanaba K, et al. Exogenous application of hydrogen sulfide donor attenuates inflammatory reactions through the L-selectin-involved pathway in the cutaneous reverse passive Arthus reaction. J Leukoc Biol. 2013;93:573-84 pubmed publisher
    ..To assess the roles of H2S in the IC-induced diseases, the cutaneous, reverse passive Arthus reaction was conducted using NaHS as a H2S donor...
  19. Braselmann S, Taylor V, Zhao H, Wang S, Sylvain C, Baluom M, et al. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. J Pharmacol Exp Ther. 2006;319:998-1008 pubmed
    ..oral administration of R406 to mice reduced immune complex-mediated inflammation in a reverse-passive Arthus reaction and two antibody-induced arthritis models...
  20. Nezhinskaya G, Sapronov N, Vladykin A, Shepeleva V. Effects of cholinotropic and cytostatic drugs on the development of Arthus reaction. Bull Exp Biol Med. 2008;146:747-9 pubmed
    ..Antimuscarinic effects of ipratropium bromide and atropine are associated with prevention of the development of Arthus reaction, while the cytostatic effects of cyclophosphamide and doxorubicin lead to involution of the thymus and spleen,..
  21. Thierfelder C, Fluckiger U. [Arm swelling and local skin reaction after Di-Te vaccination. 2 case reports]. Praxis (Bern 1994). 2004;93:1929-31 pubmed
  22. Matsuse H, Nakata H, Fukahori S, Tsuchida T, Kawano T, Tomari S, et al. A clinical evaluation of definitive and clinical allergic bronchopulmonary mycosis. Intern Med. 2006;45:759-62 pubmed
    ..The present study aims to overcome problems associated with the early diagnosis of allergic bronchopulmonary mycosis (ABPM) using the current criteria...
  23. Orito H, Fujimoto M, Ishiura N, Yanaba K, Matsushita T, Hasegawa M, et al. Intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 cooperatively contribute to the cutaneous Arthus reaction. J Leukoc Biol. 2007;81:1197-204 pubmed
    ..and VCAM-1, the major regulators of leukocyte firm adhesion, were examined in the cutaneous reverse-passive Arthus reaction using ICAM-1-deficient (ICAM-1-/-) mice and blocking mAb against VCAM-1...
  24. Melegari A, Mascia M, Sandri G, Carbonieri A. Immunodeficiency and autoimmune phenomena in female hyper-IgM syndrome. Ann N Y Acad Sci. 2007;1109:106-8 pubmed
    ..Immunodeficiency and autoimmune phenomena may occur concomitantly in the same individual and sometimes the differential diagnosis is difficult...
  25. Marx J. Immunology. Antibodies kill by producing ozone. Science. 2002;298:1319 pubmed
  26. Bellavia A, Marino V, Gallo E, Peri S, Bentivegna C, Agresti L, et al. Contact sensitivity to oxazolone in the chicken: evidence for Arthus type hypersensitivity of the cutaneous reaction. Immunopharmacol Immunotoxicol. 1992;14:233-50 pubmed
    ..The relationship between cutaneous Arthus reaction and anaphylactic shock in chickens sensitized to oxazolone is discussed.
  27. Baumann U, Chouchakova N, Gewecke B, Kohl J, Carroll M, Schmidt R, et al. Distinct tissue site-specific requirements of mast cells and complement components C3/C5a receptor in IgG immune complex-induced injury of skin and lung. J Immunol. 2001;167:1022-7 pubmed
    We induced the passive reverse Arthus reaction to IgG immune complexes (IC) at different tissue sites in mice lacking C3 treated or not with a C5aR-specific antagonist, or in mice lacking mast cells (Kit(W)/Kit(W-v) mice), and compared ..
  28. Yanagihara Y, Kasai H, Kawashima T, Ninomiya K. Immunopharmacological studies on TBX, a new antiallergic drug (4). Effects on type II to IV allergic reactions and immunological functions in animal models. Jpn J Pharmacol. 1989;51:93-100 pubmed
  29. Ohmori K, Ishii H, Manabe H, Satoh H, Tamura T, Kase H. Antiinflammatory and antiallergic effects of a novel metabolite of Nocardiopsis sp. as a potent protein kinase C inhibitor from microbial origin. Arzneimittelforschung. 1988;38:809-14 pubmed
    ..effects on rat paw edema induced by carrageenin, zymosan, PAF, and antigen-antibody reaction (passive Arthus reaction) and on the croton oil-induced rat ear edema. On the other hand, indomethacin (10 mg/kg p.o...
  30. Kanny G. [Allergies and hypersensibility in childhood and adult]. Rev Prat. 2007;57:1129-37 pubmed
  31. Ellsworth J, Maurer M, Harder B, Hamacher N, Lantry M, Lewis K, et al. Targeting immune complex-mediated hypersensitivity with recombinant soluble human FcgammaRIA (CD64A). J Immunol. 2008;180:580-9 pubmed
    ..systemic delivery only of rh-FcgammaRIA, however, reduced edema and neutrophil infiltration in the cutaneous Arthus reaction in mice...
  32. Horner A, Takabayashi K, Beck L, Sharma B, Zubeldia J, Baird S, et al. Optimized conjugation ratios lead to allergen immunostimulatory oligodeoxynucleotide conjugates with retained immunogenicity and minimal anaphylactogenicity. J Allergy Clin Immunol. 2002;110:413-20 pubmed
    ..However, investigations suggest that allergen/immunostimulatory sequence oligodeoxynucleotide (ISS-ODN) conjugates (AICs) might have improved safety and efficacy compared with allergen extracts...
  33. Singh R, Bhari R, Rana V, Tiwary A. Immunomodulatory and therapeutic potential of a mycelial lectin from Aspergillus nidulans. Appl Biochem Biotechnol. 2011;165:624-38 pubmed publisher
    ..Lectin prevented BSA-induced Arthus reaction and systemic anaphylaxis...
  34. Yanaba K, Kaburagi Y, Takehara K, Steeber D, Tedder T, Sato S. Relative contributions of selectins and intercellular adhesion molecule-1 to tissue injury induced by immune complex deposition. Am J Pathol. 2003;162:1463-73 pubmed
    ..of adhesion molecules, including selectins and ICAM-1, in this pathogenetic process, the cutaneous passive Arthus reaction was examined in mice lacking E-selectin, P-selectin, or both L-selectin and ICAM-1 with anti-P- or E-selectin ..
  35. Berden J, Hang L, McConahey P, Dixon F. Analysis of vascular lesions in murine SLE. I. Association with serologic abnormalities. J Immunol. 1983;130:1699-705 pubmed be related to a defective inflammatory response, because WBF1 mice had an undiminished reverse passive Arthus reaction throughout their lives...
  36. Yonemasu K, Crowle A. Identification and characterization of guinea-pig antibodies that contrasensitize in mice. Immunology. 1978;34:989-98 pubmed
  37. D Acquisto F, Ianaro A, Ialenti A, Maffia P, Maiuri M, Carnuccio R. Transcription factor decoy oligodeoxynucleotides to nuclear factor-kappaB inhibit reverse passive Arthus reaction in rat. Naunyn Schmiedebergs Arch Pharmacol. 2001;364:422-9 pubmed
    In the present study we investigated in the reverse passive Arthus reaction elicited in the rat skin the anti-inflammatory effect of double-stranded oligodeoxynucleotides (ODN) with consensus nuclear factor-kappaB (NF-kappaB) sequence as ..
  38. Pons F, Rossi A, Norman K, Williams T, Nourshargh S. Role of platelet-activating factor (PAF) in platelet accumulation in rabbit skin: effect of the novel long-acting PAF antagonist, UK-74,505. Br J Pharmacol. 1993;109:234-42 pubmed
    ..However, they question the role of PAF receptors on platelets in this model. The results also indicate that PAF may be involved in platelet accumulation induced by zymosan in rabbit skin...
  39. Walport M, Taylor P. Immunology: what is the proximal cause of inflammation?. Curr Biol. 1997;7:R41-3 pubmed
    ..Knockout mice lacking either the antibody constant region (Fc) receptor or the substance P receptor fail to produce a model inflammatory response, implicating these two receptors in early events of inflammation...
  40. Inada S, Kohashi O, Hamasaki Y. Humoral immune-mediated acute, antigen-induced arthritis in rats is suppressed by the inducing antigen administered orally before, but not after, immunization. Immunol Invest. 2001;30:47-56 pubmed
    Acute ovalbumin-induced arthritis (OIA), which is mediated by Arthus reaction to ovalbumin (OVA) in the joint space, can be induced by immunization of rats with OVA followed by the intraarticular injection of OVA...
  41. von Blomberg M, Boerrigter G, Scheper R. Interference of simultaneous skin tests in delayed hypersensitivity. Immunology. 1978;35:361-7 pubmed
    ..When an Arthus reaction was elicited simultaneously with a delayed hypersensitivity (DH) reaction, no effect on the DH reaction was ..
  42. Wiege K, Ali S, Gewecke B, Novakovic A, Konrad F, Pexa K, et al. G?i2 is the essential G?i protein in immune complex-induced lung disease. J Immunol. 2013;190:324-33 pubmed publisher
  43. Shimizu K, Bae S, Hara T, Iwata Y, Yamaoka T, Komura K, et al. Involvement of gaseous low molecular monoxides in the cutaneous reverse passive Arthus reaction: cytoprotective action of carbon monoxide. Clin Exp Immunol. 2008;153:245-57 pubmed publisher
    ..To assess the role of NO and CO in the pathogenic process, the cutaneous reverse passive Arthus reaction was examined using NOS inhibitor, HO-1 stimulator and HO-1 inhibitor...
  44. Utomo A, Hirahashi J, Mekala D, Asano K, Glogauer M, Cullere X, et al. Requirement for Vav proteins in post-recruitment neutrophil cytotoxicity in IgG but not complement C3-dependent injury. J Immunol. 2008;180:6279-87 pubmed
    ..Rac GTPases are also required for development of the reverse passive Arthus reaction. A deficiency in Vav 1 and 3 does not affect neutrophil accumulation at the site of immune complex deposition,..
  45. Ravetch J. A full complement of receptors in immune complex diseases. J Clin Invest. 2002;110:1759-61 pubmed
  46. Teixeira C, Jancar S, Lima W, D Orléans Juste P, Sirois P. Association of endothelin with lung hemorrhage induced by immune complexes in rats. Inflammation. 2004;28:253-61 pubmed
    ..v. injection of the antigens (Arthus reaction) was investigated...
  47. Yanaguimoto H, Ishizuki S, Fujihira E. Anti-inflammatory effects of methotrexate on reversed passive Arthus reactions in rats. Res Commun Mol Pathol Pharmacol. 2000;107:377-86 pubmed
    ..However, the manifestation of these anti-inflammatory effects might be restricted by differences in the inflammation models in rats...
  48. Feld M, Goerge T, Hillgruber C, Steingräber A, Fastrich M, Shpacovitch V, et al. ?-1-Antitrypsin and IFN-? reduce the severity of IC-mediated vasculitis by regulation of leukocyte recruitment in vivo. J Invest Dermatol. 2012;132:2286-95 pubmed publisher
    ..To induce ICV, mice were challenged with the reverse passive Arthus reaction (RPA), the prototypic in vivo model for leukocytoclastic vasculitis (LcV), and the modulation of vascular ..
  49. Yonemasu K, Crowle A. Antigenic specificities of antibodies suppressing induction of delayed hypersensitivity in mice to dinitrophenylated proteins. Immunology. 1973;25:541-55 pubmed
  50. Pine P, Chang B, Schoettler N, Banquerigo M, Wang S, Lau A, et al. Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor. Clin Immunol. 2007;124:244-57 pubmed
  51. Grob J, Mege J, Follana J, Legre R, Andrac L, Bonerandi J. Skin necrosis after injection of aminosides. Arthus reaction, local toxicity, thrombotic process or pathergy?. Dermatologica. 1990;180:258-62 pubmed
    ..Four major mechanisms are discussed: an Arthus reaction, a thrombotic process, a direct toxicity of aminosides for subcutaneous tissue, or a pyoderma-like ..
  52. Marinier A, Martel A, Bachand C, Plamondon S, Turmel B, Daris J, et al. Novel mimics of sialyl Lewis X: design, synthesis and biological activity of a series of 2- and 3-malonate substituted galactoconjugates. Bioorg Med Chem. 2001;9:1395-427 pubmed
    ..The synthesis and the biological activity of this series of compounds are described. Lead compounds having a greater potency than sialyl Lewis X are identified...
  53. Xu D, Huang S, Wang J, Wu C. Protective effect of membrane cofactor protein against complement-dependent injury. Acta Pharmacol Sin. 2005;26:987-91 pubmed
    ..To evaluate the protective role of membrane cofactor protein (MCP, CD46) on complement-dependent injury...