immune complex diseases

Summary

Summary: Group of diseases mediated by the deposition of large soluble complexes of antigen and antibody with resultant damage to tissue. Besides SERUM SICKNESS and the ARTHUS REACTION, evidence supports a pathogenic role for immune complexes in many other IMMUNE SYSTEM DISEASES including GLOMERULONEPHRITIS, systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC) and POLYARTERITIS NODOSA.

Top Publications

  1. Welch T, Frenzke M, Witte D, Davis A. C5a is important in the tubulointerstitial component of experimental immune complex glomerulonephritis. Clin Exp Immunol. 2002;130:43-8 pubmed
    ..These data support a role for complement in the interstitial component of this glomerulonephritis model. They are consistent with our hypotheses of a role for complement in the progression of some forms of glomerulonephritis to ESRD...
  2. Bozic C, Lu B, Höpken U, Gerard C, Gerard N. Neurogenic amplification of immune complex inflammation. Science. 1996;273:1722-5 pubmed
    ..Immunoreactive substance P was measurable in fluids lining the lung at time points before neutrophil influx and may thus be involved in an early step in the inflammatory response to immune complexes in the lung...
  3. Chouchakova N, Skokowa J, Baumann U, Tschernig T, Philippens K, Nieswandt B, et al. Fc gamma RIII-mediated production of TNF-alpha induces immune complex alveolitis independently of CXC chemokine generation. J Immunol. 2001;166:5193-200 pubmed
  4. Alexander J, Aneziokoro O, Chang A, Hack B, Markaryan A, Jacob A, et al. Distinct and separable roles of the complement system in factor H-deficient bone marrow chimeric mice with immune complex disease. J Am Soc Nephrol. 2006;17:1354-61 pubmed
    ..These data show that plasma Cfh limits complement activation in the circulation and other accessible sites such as the glomerulus, whereas platelet Cfh is responsible for immune complex processing...
  5. Shushakova N, Skokowa J, Schulman J, Baumann U, Zwirner J, Schmidt R, et al. C5a anaphylatoxin is a major regulator of activating versus inhibitory FcgammaRs in immune complex-induced lung disease. J Clin Invest. 2002;110:1823-30 pubmed
    ..Therefore, C5a, which is a potent chemoattractant, has a broader critical function in regulating the inhibitory/activating FcgammaRII/III receptor pair to connect complement and FcgammaR effector pathways in immune inflammation...
  6. Godau J, Heller T, Hawlisch H, Trappe M, Howells E, Best J, et al. C5a initiates the inflammatory cascade in immune complex peritonitis. J Immunol. 2004;173:3437-45 pubmed
    ..We conclude that complement activation and C5a generation are prerequisites for IC-induced inflammation through activating FcgammaR, which amplifies complement-induced inflammation in autoimmunity...
  7. Sekine H, Reilly C, Molano I, Garnier G, Circolo A, Ruiz P, et al. Complement component C3 is not required for full expression of immune complex glomerulonephritis in MRL/lpr mice. J Immunol. 2001;166:6444-51 pubmed
    ..These results indicate that C3 and/or activation of C3 is not required for full expression of immune complex renal disease in MRL/lpr mice and may in fact play a beneficial role via clearance of immune complexes...
  8. Höpken U, Lu B, Gerard N, Gerard C. Impaired inflammatory responses in the reverse arthus reaction through genetic deletion of the C5a receptor. J Exp Med. 1997;186:749-56 pubmed
    ..These data indicate a dominant role for the C5aR and its ligand in the reverse passive Arthus reaction in the lung and a synergistic role together with other inflammatory mediators in immune complex-mediated peritonitis and skin injury...
  9. Quigg R, Lim A, Haas M, Alexander J, He C, Carroll M. Immune complex glomerulonephritis in C4- and C3-deficient mice. Kidney Int. 1998;53:320-30 pubmed
    ..These results illustrate the complex interplay between the effects of complement to process immune complexes and to lead to inflammation and tissue injury...

More Information

Publications62

  1. Weissmann G. Rheumatoid arthritis and systemic lupus erythematosus as immune complex diseases. Bull NYU Hosp Jt Dis. 2009;67:251-3 pubmed
    ..Genetic defects in the complement cascade associated with SLE result in inadequate clearance of immune complexes as well as apoptotic blebs containing autoantigens...
  2. Shushakova N, Eden G, Dangers M, Zwirner J, Menne J, Gueler F, et al. The urokinase/urokinase receptor system mediates the IgG immune complex-induced inflammation in lung. J Immunol. 2005;175:4060-8 pubmed
    ..The findings indicate an important link between the uPA/uPAR system and the two main components involved in the IC inflammation, namely, complement and FcgammaRs...
  3. Van Meurs J, van Lent P, Holthuysen A, Lambrou D, Bayne E, Singer I, et al. Active matrix metalloproteinases are present in cartilage during immune complex-mediated arthritis: a pivotal role for stromelysin-1 in cartilage destruction. J Immunol. 1999;163:5633-9 pubmed
    ..SLN-1 is a pivotal enzyme in overall MMP-activity in cartilage during immune complex-mediated arthritis...
  4. Ravetch J. A full complement of receptors in immune complex diseases. J Clin Invest. 2002;110:1759-61 pubmed
  5. Mogi G, Suzuki M, Fujiyoshi T, Ueyama S, Ichimiya I. Influence of middle ear effusion on perilymph. Acta Otolaryngol Suppl. 1989;457:116-23 pubmed
    ..The findings of the present study indicate that MEE affects the biochemical environment of PL. However, this influence was transient and reversible...
  6. Vargas L, Sewell R, Marshall A, Galatioto J, Tsong Y, Catterall J, et al. Immune complex deposition in adult male Sprague-Dawley rats chronically immunized with GnRH. Am J Reprod Immunol. 2005;54:292-310 pubmed
    ..This study was undertaken to evaluate whether the anti-GnRH antibodies and immune complexes (IC) generated by immunization with GnRH-TT cause cellular damage within the animal...
  7. George E, Nadkarni G, Estrella M, Lucas G, Sperati C, Atta M, et al. The impact of hepatitis C coinfection on kidney disease related to human immunodeficiency virus (HIV): a biopsy study. Medicine (Baltimore). 2011;90:289-95 pubmed publisher
  8. Ahmad S, Lidington E, Ohta R, Okada N, Robson M, Davies K, et al. Decay-accelerating factor induction by tumour necrosis factor-alpha, through a phosphatidylinositol-3 kinase and protein kinase C-dependent pathway, protects murine vascular endothelial cells against complement deposition. Immunology. 2003;110:258-68 pubmed
    ..The mouse represents a suitable model for the study of novel therapeutic approaches by which vascular endothelium may be conditioned against complement-mediated injury...
  9. Stokes M, Davis C, Alpers C. Collapsing glomerulopathy in renal allografts: a morphological pattern with diverse clinicopathologic associations. Am J Kidney Dis. 1999;33:658-66 pubmed
    ..These findings emphasize the prognostic significance of CG in renal allografts and suggest that CG may result from diverse pathogenic mechanisms...
  10. Glazer E, Ejaz A, Coley C, Bednarek K, Theise N. Fibrin ring granuloma in chronic hepatitis C: virus-related vasculitis and/or immune complex disease?. Semin Liver Dis. 2007;27:227-30 pubmed
  11. Horike K, Takeda A, Otsuka Y, Inaguma D, Goto N, Watarai Y, et al. A case of recurrent light chain deposition disease after living-related renal transplantation - detailed process of the recurrence. Clin Transplant. 2012;26 Suppl 24:64-9 pubmed publisher
    ..Typical IF staining pattern of lambda and EDD compatible with LCDD were noted after six months post-transplant. This is the first case report that elucidated the details of the recurrent process of LCDD at one yr after the operation...
  12. Raptis S, Pham C. Neutrophil-derived serine proteases in immune complex-mediated diseases. Immunol Res. 2005;32:211-5 pubmed
    ..Loss-of-function mutations in serine proteases have provided critical insights into the significance of these serine proteases in initiating and amplifying immune complex-mediated diseases...
  13. Setiady Y, Pramoonjago P, Tung K. Requirements of NK cells and proinflammatory cytokines in T cell-dependent neonatal autoimmune ovarian disease triggered by immune complex. J Immunol. 2004;173:1051-8 pubmed
    ..Also operative in neonatal AOD are other mediators of the innate system, including proinflammatory cytokines and FcgammaRIII signaling...
  14. Allam R, Lichtnekert J, Moll A, Taubitz A, Vielhauer V, Anders H. Viral RNA and DNA trigger common antiviral responses in mesangial cells. J Am Soc Nephrol. 2009;20:1986-96 pubmed publisher
    ..We conclude that 3P-RNA and double-stranded DNA trigger a common, TLR-independent, antiviral response in glomerular mesangial cells, which may promote glomerulonephritis in the setting of viral infection...
  15. Saddadi F, Attari F, Najafi I, Gangi M, Hakemi M, Amini M. Renal involvement in patients with hepatitis C virus infection. Iran J Kidney Dis. 2010;4:123-7 pubmed
    ..The aim of this study was to evaluate renal involvement in HCV-infected patients...
  16. Lapa A, Appenzeller S, Bertolo M. Schistosoma mansoni infection: an immune complex disease presenting with polyarthritis. Rheumatol Int. 2013;33:1341-3 pubmed publisher
    ..mansoni infection. We will discuss pathophysiology and clinical manifestations of S. mansoni infection with special attention to articular involvement...
  17. Escudier M, Bagan J, Scully C. Number VII Behçet's disease (Adamantiades syndrome). Oral Dis. 2006;12:78-84 pubmed
    ..An inflammatory disorder, BS is now considered as a systemic vasculitis, characterised by a very wide spectrum of clinical features and by unpredictable exacerbations and remissions...
  18. Gershwin L. Autoimmune diseases in small animals. Vet Clin North Am Small Anim Pract. 2010;40:439-57 pubmed publisher
    ..Likewise, the suggested role of environmental or infectious agents is another commonality between humans and their pets...
  19. Sheerin N, Springall T, Carroll M, Sacks S. Altered distribution of intraglomerular immune complexes in C3-deficient mice. Immunology. 1999;97:393-9 pubmed
    ..We conclude that, although complement is required for the normal glomerular metabolism of immune complexes, other, complement-independent, factors are involved in the generation of glomerular injury in this model...
  20. Wang Y, Hu Q, Madri J, Rollins S, Chodera A, Matis L. Amelioration of lupus-like autoimmune disease in NZB/WF1 mice after treatment with a blocking monoclonal antibody specific for complement component C5. Proc Natl Acad Sci U S A. 1996;93:8563-8 pubmed
  21. Kanno H, Tachiwaki O, Nose M, Kyogoku M. Immune complex-degradation ability of macrophages in MRL/Mp-lpr/lpr lupus mice and its regulation by cytokines. Clin Exp Immunol. 1994;95:115-21 pubmed
  22. Nova J, Sanchez G. [Leprosy reactions in a Colombian national reference centre]. Biomedica. 2013;33:99-106 pubmed publisher
    ..Colombia is the country in America with the highest proportion of new cases leprosy with severe disability. To decrease such disability it is necessary to control these reactions, the main cause of nerve damage in leprosy...
  23. Fujino S, Sakurabayashi I. [Immunological tests: Anaphylatoxins C3a, C4a, C5a]. Nihon Rinsho. 2005;63 Suppl 7:80-3 pubmed
  24. Hill P. A rare form of crescentic glomerulonephritis with mixed immunopathological features. Pathology. 2004;36:580-1 pubmed
  25. Trouw L, Groeneveld T, Seelen M, Duijs J, Bajema I, Prins F, et al. Anti-C1q autoantibodies deposit in glomeruli but are only pathogenic in combination with glomerular C1q-containing immune complexes. J Clin Invest. 2004;114:679-88 pubmed
    ..This provides an explanation why anti-C1q antibodies are especially pathogenic in patients with SLE...
  26. Gama Landgraf R, Jancar S, Steil A, Sirois P. Modulation of allergic and immune complex-induced lung inflammation by bradykinin receptor antagonists. Inflamm Res. 2004;53:78-83 pubmed
    ..The effect of bradykinin (B(1) or B(2)) receptor antagonists was studied in allergic and immune-complex-induced lung inflammation...
  27. Kohl J, Gessner J. On the role of complement and Fc gamma-receptors in the Arthus reaction. Mol Immunol. 1999;36:893-903 pubmed
    ..The activation of the C5a receptor pathway appears to be the prominent contribution of the complement system...
  28. Jennette J. Implications for pathogenesis of patterns of injury in small- and medium-sized-vessel vasculitis. Cleve Clin J Med. 2002;69 Suppl 2:SII33-8 pubmed
    ..The pathology of the necrotizing vasculitis of polyarteritis nodosa and small-vessel vasculitis, including ANCA-vasculitis, is most consistent with a primary role for neutrophils and monocytes in the acute injury...
  29. Barabas A, Cole C, Barabas A, Lafreniere R. Production of Heymann nephritis by a chemically modified renal antigen. Int J Exp Pathol. 2004;85:277-85 pubmed
  30. Amore A, Coppo R, Nedrud J, Sigmund N, Lamm M, Emancipator S. The role of nasal tolerance in a model of IgA nephropathy induced in mice by Sendai virus. Clin Immunol. 2004;113:101-8 pubmed
    ..Viremia in a non-tolerized immune host can promote glomerulonephritis with IgG and complement codeposits and glomerular dysfunction. These preliminary experiments may guide future, more mechanistic, investigation...
  31. Dass R, Barman H, Duwarah S, Deka N, Jain P, Choudhury V. Immune complex reaction after successful treatment of meningococcal disease: an excellent response to IVIG. Rheumatol Int. 2013;33:231-3 pubmed publisher
    ..We report excellent response to intravenous immunoglobulin in a child with immune complex reaction following meningococcal sepsis...
  32. Friedmann P, Lee M, Friedmann A, Barnetson R. Mechanisms in cutaneous drug hypersensitivity reactions. Clin Exp Allergy. 2003;33:861-72 pubmed
    ..This will also become of great value for prediction of individuals at risk of becoming sensitized by a particular drug...
  33. Daniel L, Dorel Le Théo M, Bruno D, Tsimaratos M, Pellissier J. [Renal pathology: a rare association of immunoglobulin deposits]. Ann Pathol. 2002;22:485-6 pubmed
  34. Chen M, Daha M, Kallenberg C. The complement system in systemic autoimmune disease. J Autoimmun. 2010;34:J276-86 pubmed publisher
    ..This has been demonstrated for monoclonal antibodies to C5 or C5a in experimental anti-phospholipid antibody syndrome and ANCA-associated vasculitis...
  35. Descotes J, Choquet Kastylevsky G. Gell and Coombs's classification: is it still valid?. Toxicology. 2001;158:43-9 pubmed
    ..In fact, three different situations can be identified, namely pseudo-allergic reactions, primarily antibody-mediated reactions and cell-mediated reactions, which could serve as a basis for modern and more adequate classifications..
  36. Senbagavalli P, Geetha S, Venkatesan P, Ramanathan V. Defective solubilization of immune complexes and activation of the complement system in patients with pulmonary tuberculosis. J Clin Immunol. 2009;29:674-80 pubmed publisher
  37. Ko H, Hernandez Prera J, Zhu H, Dikman S, Sidhu H, Ward S, et al. Morphologic features of extrahepatic manifestations of hepatitis C virus infection. Clin Dev Immunol. 2012;2012:740138 pubmed publisher
    ..This paper highlights the histomorphologic features of these processes, which are typically characterized by chronic inflammation, immune complex deposition, and immunoproliferative disease in the affected organ...
  38. Robertson J. Chemically induced glomerular injury: a review of basic mechanisms and specific xenobiotics. Toxicol Pathol. 1998;26:64-72 pubmed
    ..Furthermore, they provide a means to understand the basis for renal damage and the progression of renal disease once injury has occurred...
  39. Martin L, Charon Barra C, Bocrie O, Guignier F, D Athis P, Dautin G, et al. Detection of plasma cells, C4d deposits and donor-specific antibodies on sequential graft biopsies of renal transplant recipients with chronic dysfunction. Transpl Immunol. 2010;22:110-4 pubmed publisher
  40. Kallenberg C. Vasculitis: clinical approach, pathophysiology and treatment. Wien Klin Wochenschr. 2000;112:656-9 pubmed
    ..Less toxic regimens as well as new treatment modalities based on insight into the pathophysiology of systemic vasculitides have been developed and are currently being tested in multicentre European studies...
  41. Moreira M, Kanashiro A, Kabeya L, Polizello A, Azzolini A, Curti C, et al. Neutrophil effector functions triggered by Fc-gamma and/or complement receptors are dependent on B-ring hydroxylation pattern and physicochemical properties of flavonols. Life Sci. 2007;81:317-26 pubmed
    ..Our results suggested that inhibition of IC-stimulated PMNs effector functions by the flavonols tested herein was the result of cooperation of different cellular mechanisms...
  42. Cui Z, Zhao M, Wang S, Liu G, Zou W, Wang H. Concurrent antiglomerular basement membrane disease and immune complex glomerulonephritis. Ren Fail. 2006;28:7-14 pubmed
    ..Plasma exchange and extensive immunosuppressive therapy should be carried out as soon as possible. The immune complexes deposited in glomeruli might participate in the initiation of anti-GBM disease...
  43. Ta V, Nagaoka H, Catalan N, Durandy A, Fischer A, Imai K, et al. AID mutant analyses indicate requirement for class-switch-specific cofactors. Nat Immunol. 2003;4:843-8 pubmed
    ..These results indicate that AID requires interaction with a cofactor(s) specific to CSR...
  44. Vaseemuddin M, Schwartz M, Dunea G, Kraus M. Idiopathic hypocomplementemic immune-complex-mediated tubulointerstitial nephritis. Nat Clin Pract Nephrol. 2007;3:50-8 pubmed
    ..A 42-year-old man presenting with flank pain was found to have renal failure with severe hypocomplementemia and eosinophilia...
  45. Anders H, Banas B, Linde Y, Weller L, Cohen C, Kretzler M, et al. Bacterial CpG-DNA aggravates immune complex glomerulonephritis: role of TLR9-mediated expression of chemokines and chemokine receptors. J Am Soc Nephrol. 2003;14:317-26 pubmed
    ..This mechanism may be relevant during infection-triggered exacerbation of human immune-complex GN and other immune-mediated diseases in general...
  46. Kusaba G, Ohsawa I, Ishii M, Inoshita H, Ohi H, Horikoshi S, et al. Evidence of immunopathological traces in mucormycosis: an autopsy case. Clin Exp Nephrol. 2010;14:396-400 pubmed publisher
    ..This report shows evidence of complement opsonization of Mucor hyphae and refers to mucormycosis that developed small-sized vasculitis with complement activation...
  47. Mayadas T, Rosenkranz A, Cotran R. Glomerular inflammation: use of genetically deficient mice to elucidate the roles of leukocyte adhesion molecules and Fc-gamma receptors in vivo. Curr Opin Nephrol Hypertens. 1999;8:293-8 pubmed
  48. Li Z, Woo C, Scharff M. Mutations in AID and UNG extend the function of AID. Nat Immunol. 2003;4:945-6 pubmed
  49. Shanley T, Schmal H, Friedl H, Jones M, Ward P. Role of macrophage inflammatory protein-1 alpha (MIP-1 alpha) in acute lung injury in rats. J Immunol. 1995;154:4793-802 pubmed
    ..The role of MIP-1 alpha seems to be related to production of TNF-alpha, which in turn up-regulates vascular adhesion molecules required for neutrophil influx...
  50. Mulligan M, Vaporciyan A, Warner R, Jones M, Foreman K, Miyasaka M, et al. Compartmentalized roles for leukocytic adhesion molecules in lung inflammatory injury. J Immunol. 1995;154:1350-63 pubmed
  51. Yaswen L, Kulkarni A, Fredrickson T, Mittleman B, Schiffman R, Payne S, et al. Autoimmune manifestations in the transforming growth factor-beta 1 knockout mouse. Blood. 1996;87:1439-45 pubmed
    ..Our results describe autoimmune activity that ensues when the TGF-beta 1 cytokine is absent...
  52. Alexander J, Chaves L, Chang A, Quigg R. The C5a receptor has a key role in immune complex glomerulonephritis in complement factor H-deficient mice. Kidney Int. 2012;82:961-8 pubmed publisher
    ..Thus, IgG- and iC3b-containing immune complexes are not inflammatory in C57BL/6 mice. Yet when these mice lack CFH, sufficient C3b persists in glomeruli to generate C5a and activate C5aR...
  53. Fernández N, Jancar S, Sánchez Crespo M. Blood and endothelium in immune complex-mediated tissue injury. Trends Pharmacol Sci. 2004;25:512-7 pubmed
    ..The activation of platelets and coagulation, if not properly counterbalanced by fibrinolysis, might be a major factor for the late development of fibrotic changes and organ remodeling...