wheat hypersensitivity

Summary

Summary: Allergic reaction to wheat that is triggered by the immune system.

Top Publications

  1. Mittag D, Niggemann B, Sander I, Reese I, Fiedler E, Worm M, et al. Immunoglobulin E-reactivity of wheat-allergic subjects (baker's asthma, food allergy, wheat-dependent, exercise-induced anaphylaxis) to wheat protein fractions with different solubility and digestibility. Mol Nutr Food Res. 2004;48:380-9 pubmed
    ..However, ethanol-soluble gliadins were stable to gastric enzymes and exhibit low solubility in gastric and duodenal fluids. Therefore, they are likely to be important in food allergy to wheat...
  2. Park H, Kim J, Kim J, Jin H, Choi G, Ye Y, et al. Diagnostic value of the serum-specific IgE ratio of ?-5 gliadin to wheat in adult patients with wheat-induced anaphylaxis. Int Arch Allergy Immunol. 2012;157:147-50 pubmed publisher
    ..The compound ?-5 gliadin has been identified as a major allergen for WDEIA and WIA. We evaluated the diagnostic value of serum immunoglobulin E (IgE) ratios of ?-5 gliadin to wheat in adult patients with WDEIA or WIA...
  3. Palosuo K. Update on wheat hypersensitivity. Curr Opin Allergy Clin Immunol. 2003;3:205-9 pubmed
    ..This review outlines the diverse clinical manifestations of IgE-mediated wheat hypersensitivity and summarizes recent advances in characterization of clinically significant allergens.
  4. Matsuo H, Dahlstrom J, Tanaka A, Kohno K, Takahashi H, Furumura M, et al. Sensitivity and specificity of recombinant omega-5 gliadin-specific IgE measurement for the diagnosis of wheat-dependent exercise-induced anaphylaxis. Allergy. 2008;63:233-6 pubmed publisher
  5. Bittner C, Grassau B, Frenzel K, Baur X. Identification of wheat gliadins as an allergen family related to baker's asthma. J Allergy Clin Immunol. 2008;121:744-9 pubmed
    ..Therefore the reliability of current diagnostic procedures is insufficient. Only few of the suspected causative wheat allergens have been hitherto characterized on the molecular level...
  6. Marietta E, Black K, Camilleri M, Krause P, Rogers R, David C, et al. A new model for dermatitis herpetiformis that uses HLA-DQ8 transgenic NOD mice. J Clin Invest. 2004;114:1090-7 pubmed
    ..This animal model of DH will be useful to determine the specificity of the IgA deposits, as well as the pathogenic mechanisms that occur in the skin as a result of gluten ingestion...
  7. Bouchez Mahiout I, Pecquet C, Kerre S, Snégaroff J, Raison Peyron N, Lauriere M. High molecular weight entities in industrial wheat protein hydrolysates are immunoreactive with IgE from allergic patients. J Agric Food Chem. 2010;58:4207-15 pubmed publisher
    ..These multiepitopic entities could explain the high immunogenicity of HWP for sensitized people...
  8. Ueno M, Adachi A, Fukumoto T, Nishitani N, Fujiwara N, Matsuo H, et al. [Analysis of causative allergen of the patient with baker's asthma and wheat-dependent exercise-induced anaphylaxis (WDEIA)]. Arerugi. 2010;59:552-7 pubmed
    ..Wheat gliadins might be causative allergen of both baker's asthma and WDEIA in our case...
  9. Oyefara B, Bahna S. Delayed food-dependent, exercise-induced anaphylaxis. Allergy Asthma Proc. 2007;28:64-6 pubmed

More Information

Publications62

  1. Pootongkam S, Nedorost S. Oat and wheat as contact allergens in personal care products. Dermatitis. 2013;24:291-5 pubmed publisher
    ..Complete avoidance of oat- or wheat-derived products is suggested as we cannot conclude that some oat- or wheat-derived components such as oils are free of protein...
  2. Nucera E, Pollastrini E, De Pasquale T, Buonomo A, Roncallo C, Lombardo C, et al. New protocol for desensitization to wheat allergy in a single case. Dig Dis Sci. 2005;50:1708-9 pubmed
  3. Matsuo H, Kohno K, Morita E. Molecular cloning, recombinant expression and IgE-binding epitope of omega-5 gliadin, a major allergen in wheat-dependent exercise-induced anaphylaxis. FEBS J. 2005;272:4431-8 pubmed
    ..Our results suggest that the recombinant protein can be a useful tool for identifying patients with wheat-dependent exercise-induced anaphylaxis in vitro...
  4. Okada Y, Yanagida N, Sato S, Ebisawa M. Better management of wheat allergy using a very low-dose food challenge: A retrospective study. Allergol Int. 2016;65:82-7 pubmed publisher
    ..001). A VL OFC can shift the management of some low-dose reactive wheat-allergic children from complete avoidance to partial wheat intake. ..
  5. Beyer K, Chung D, Schulz G, Mishoe M, Niggemann B, Wahn U, et al. The role of wheat omega-5 gliadin IgE antibodies as a diagnostic tool for wheat allergy in childhood. J Allergy Clin Immunol. 2008;122:419-21 pubmed publisher
  6. Niggemann B, Celik Bilgili S, Ziegert M, Reibel S, Sommerfeld C, Wahn U. Specific IgE levels do not indicate persistence or transience of food allergy in children with atopic dermatitis. J Investig Allergol Clin Immunol. 2004;14:98-103 pubmed
    ..The aim of the study was to evaluate whether specific IgE levels in serum could be a useful predictor of the outcome of oral re-challenges...
  7. Pérez Pimiento A, Rodríguez Cabreros M, Lombardero M, Prieto L, Reaño M, Iglesias A. Late-onset food hypersensitivity to wheat flour. J Investig Allergol Clin Immunol. 2007;17:202-3 pubmed
  8. Murphy T, Sheffer A. Occupational asthma: a case of Baker's asthma. Allergy Asthma Proc. 2004;25:151-6 pubmed
    ..Treatment modalities used for occupational asthma are similar to those used in the management of other forms of asthma, with particular attention to reducing the level of exposure to the inciting allergen...
  9. Ito S. [Standardization of diagnosis and management of food allergy]. Arerugi. 2006;55:1491-6 pubmed
  10. Nakamura K, Inomata N, Ikezawa Z. Dramatic augmentation of wheat allergy by aspirin in a dose-dependent manner. Ann Allergy Asthma Immunol. 2006;97:712-3 pubmed
  11. Chinuki Y, Takahashi H, Dekio I, Kaneko S, Tokuda R, Nagao M, et al. Higher allergenicity of high molecular weight hydrolysed wheat protein in cosmetics for percutaneous sensitization. Contact Dermatitis. 2013;68:86-93 pubmed publisher
    ..Several cases of contact urticaria following exposure to hydrolysed wheat protein (HWP) in cosmetics or of anaphylaxis caused by deamidated gluten in food or non-food products have been described...
  12. Villalta D, Longo G, Mistrello G, Amato S, Asero R. A case of rice allergy in a patient with baker's asthma. Eur Ann Allergy Clin Immunol. 2012;44:207-9 pubmed
    ..On ISAC 112 IgE reactivity to wheat alpha-amylase/trypsin inhibitor (nTri a aA_TI) and lipid tranfer protein (rTri a 14) was found. We hypothesize that the reaction by oral ingestion was elicited by homologous molecules in rice seeds...
  13. Aziz I, Sanders D. The irritable bowel syndrome-celiac disease connection. Gastrointest Endosc Clin N Am. 2012;22:623-37 pubmed publisher
    ..Some patients with IBS without CD may derive symptomatic benefit from a gluten-free diet. Future research could facilitate a significant impact on the quality of life in this potential subgroup of patients...
  14. Richard C, Peres G, Guillaume G, Leduc V, Denery Papini S, Battais F, et al. Specific IgG levels to wheat in wheat tolerant professional cyclists may depend on a homeostatic immune response to a high consumption of wheat. Eur Ann Allergy Clin Immunol. 2012;44:243-50 pubmed
    ..Our objectives are to compare levels of IgG antibodies to wheat protein fractions in healthy non atopic or atopic subjects, and in healthy professional cyclist subjects, taking into account the quantitative consumption of wheat...
  15. Scherf K, Brockow K, Biedermann T, Koehler P, Wieser H. Wheat-dependent exercise-induced anaphylaxis. Clin Exp Allergy. 2016;46:10-20 pubmed publisher
    ..The most reliable prophylaxis of WDEIA is a gluten-free diet. In less severe cases, a strict limitation of wheat ingestion before exercise and avoidance of other cofactors may be sufficient. ..
  16. Herzinger T, Kick G, Ludolph Hauser D, Przybilla B. Anaphylaxis to wheat beer. Ann Allergy Asthma Immunol. 2004;92:673-5 pubmed
    ..Despite its worldwide and abundant consumption, beer has rarely been found to cause anaphylaxis. Barley malt contained in lager beers seems to be an important elicitor...
  17. Merget R, Sander I, van Kampen V, Beckmann U, Heinze E, Raulf Heimsoth M, et al. Allergic asthma after flour inhalation in subjects without occupational exposure to flours: an experimental pilot study. Int Arch Occup Environ Health. 2011;84:753-60 pubmed publisher
    ..Cross-reactivity between grass pollen and grain flour allergens is well known, but their significance in apprentice bakers with primary sensitization to grass pollen is not known...
  18. Yokooji T, Kurihara S, Murakami T, Chinuki Y, Takahashi H, Morita E, et al. Characterization of causative allergens for wheat-dependent exercise-induced anaphylaxis sensitized with hydrolyzed wheat proteins in facial soap. Allergol Int. 2013;62:435-45 pubmed publisher
    ..5-Gliadin and HMW-glutenin were identified as major allergens in conventional WP-WDEIA patients. However, the allergens in HWP-WDEIA have yet to be elucidated...
  19. Mameri H, Snégaroff J, Gohon Y, Pecquet C, Choudat D, Raison Peyron N, et al. Immunoglobulin-E reactivity and structural analysis of wheat low-molecular-weight glutenin subunits and their repetitive and nonrepetitive halves. J Agric Food Chem. 2012;60:7538-47 pubmed publisher
    ..IgE reactivity was correlatively increased, as when the halves were associated in the B16-P73 chimera. These results suggest that structural interaction between N- and C-terminal halves may promote epitope presentation. ..
  20. Morita E, Chinuki Y, Takahashi H, Nabika T, Yamasaki M, Shiwaku K. Prevalence of wheat allergy in Japanese adults. Allergol Int. 2012;61:101-5 pubmed publisher
    ..Wheat is one of the most common causes of food allergies. The exact prevalence of wheat allergy has not been well delineated in Japanese adults...
  21. Venter C, Arshad S. Epidemiology of food allergy. Pediatr Clin North Am. 2011;58:327-49, ix pubmed publisher
    ..This cannot be stated with confidence, however, without the use of consistent methodology and diagnostic criteria...
  22. Ahanchian H, Farid R, Ansari E, Kianifar H, Jabbari Azad F, Jafari S, et al. Food-dependent exercise-induced anaphylaxis due to wheat in a young woman. Iran J Allergy Asthma Immunol. 2013;12:93-5 pubmed publisher
    ..The patient was diagnosed as wheat-dependent exercise-induced, and all foods containing wheat were omitted from her diet. In this report we emphasized on the importance of careful history taking in anaphylaxis diagnosis...
  23. Potter M, Walker M, Talley N. Non-coeliac gluten or wheat sensitivity: emerging disease or misdiagnosis?. Med J Aust. 2017;207:211-215 pubmed
    ..Identification of NCG/WS is important as gluten-free diets carry risks, are socially restricting and are costlier than regular diets...
  24. Nermes M, Karvonen H, Sarkkinen E, Isolauri E. Safety of barley starch syrup in patients with allergy to cereals. Br J Nutr. 2009;101:165-8 pubmed
    ..This study confirmed with 98% confidence that at least 90% of the patients with verified allergy to cereals will not react with allergic symptoms to barley starch syrup...
  25. Lidén M, Kristjansson G, Valtysdottir S, Venge P, Hallgren R. Self-reported food intolerance and mucosal reactivity after rectal food protein challenge in patients with rheumatoid arthritis. Scand J Rheumatol. 2010;39:292-8 pubmed publisher
    ..A secondary aim was to relate self-experienced adverse reactions to dairy produce and wheat to the local mucosal reactivity observed after rectal challenge with cow's milk protein (CM) and wheat gluten...
  26. Michaelsson G, Kristjansson G, Pihl Lundin I, Hagforsen E. Palmoplantar pustulosis and gluten sensitivity: a study of serum antibodies against gliadin and tissue transglutaminase, the duodenal mucosa and effects of gluten-free diet. Br J Dermatol. 2007;156:659-66 pubmed
    ..Some patients also have psoriasis. A subgroup of patients with psoriasis has been shown to have silent gluten sensitivity with relevance for their psoriasis. Nothing is known about gluten sensitivity in PPP...
  27. D Arienzo R, Maurano F, Luongo D, Mazzarella G, Stefanile R, Troncone R, et al. Adjuvant effect of Lactobacillus casei in a mouse model of gluten sensitivity. Immunol Lett. 2008;119:78-83 pubmed publisher
    ..Moreover, our data imply that the intrinsic adjuvanticity of L. casei can be exploited to further enhance both mucosal and systemic T cell-mediated responses...
  28. Biagini R, MacKenzie B, Sammons D, Smith J, Striley C, Robertson S, et al. Evaluation of the prevalence of antiwheat-, anti-flour dust, and anti-alpha-amylase specific IgE antibodies in US blood donors. Ann Allergy Asthma Immunol. 2004;92:649-53 pubmed
    ..2% to 6.4%...
  29. Constantin C, Touraev A, Heberle Bors E, Quirce S, Huber W, Valenta R. Detection of antigens reactive to IgE and IgA during wheat seed maturation and in different wheat cultivars. Int Arch Allergy Immunol. 2009;149:181-7 pubmed publisher
    ..Dietary intake of wheat causes hypersensitivity reactions in patients suffering from IgE-mediated food allergy and coeliac disease...
  30. Cantani A, Micera M. The prick by prick test is safe and reliable in 58 children with atopic dermatitis and food allergy. Eur Rev Med Pharmacol Sci. 2006;10:115-20 pubmed
    ..In addition we stress that FA cannot be excluded only because skin prick tests (SPTs) are negative, as recently suggested...
  31. Mojibian M, Chakir H, MacFarlane A, Lefebvre D, Webb J, Touchie C, et al. Immune reactivity to a glb1 homologue in a highly wheat-sensitive patient with type 1 diabetes and celiac disease. Diabetes Care. 2006;29:1108-10 pubmed
  32. Stuurman B, Meijster T, Heederik D, Doekes G. Inhalable beta(1->3)glucans as a non-allergenic exposure factor in Dutch bakeries. Occup Environ Med. 2008;65:68-70 pubmed
    ..To obtain an overview of inhalable beta(1-->3)glucans levels in Dutch industrial bakeries and explore possible associations with reported respiratory health effects in bakery workers...
  33. Pacharn P, Kumjim S, Tattiyapong P, Jirapongsananuruk O, Piboonpocanun S. Identification of wheat sensitization using an in-house wheat extract in Coca-10% alcohol solution in children with wheat anaphylaxis. Asian Pac J Allergy Immunol. 2016;34:153-8 pubmed publisher
    ..Wheat allergens are both water/salt and alcohol soluble. The preparation of wheat extract for SPT containing both water/salt and alcohol soluble allergen is needed...
  34. Sonier B, Strom A, Wang G, Patrick C, Crookshank J, Mojibian M, et al. Antibodies from a patient with type 1 diabetes and celiac disease bind to macrophages that express the scavenger receptor CD163. Can J Gastroenterol. 2011;25:327-9 pubmed
    ..The novel finding of putative autoantibodies against tolerogenic intestinal CD163? macrophages suggests that regulatory macrophages were targeted in this patient with celiac disease and T1D...
  35. Sato S, Tachimoto H, Shukuya A, Ogata M, Komata T, Imai T, et al. Utility of the peripheral blood basophil histamine release test in the diagnosis of hen's egg, cow's milk, and wheat allergy in children. Int Arch Allergy Immunol. 2011;155 Suppl 1:96-103 pubmed publisher
    ..The utility of the histamine release test (HRT) in the diagnosis of childhood FA has not been fully examined...
  36. Jin Y, Ebaugh S, Martens A, Gao H, Olson E, Ng P, et al. A Mouse Model of Anaphylaxis and Atopic Dermatitis to Salt-Soluble Wheat Protein Extract. Int Arch Allergy Immunol. 2017;174:7-16 pubmed publisher
    ..Here we report a mouse model of anaphylaxis and atopic dermatitis to SSWP extract that may be used for further basic and applied research on wheat allergy. ..
  37. Harris Roberts J, Robinson E, Waterhouse J, Billings C, Proctor A, Stocks Greaves M, et al. Sensitization to wheat flour and enzymes and associated respiratory symptoms in British bakers. Am J Ind Med. 2009;52:133-40 pubmed publisher
    ..Current literature suggests that flour exposed workers continue to be at risk of allergic sensitization to flour dust and respiratory ill health...
  38. Boukid F, Prandi B, Sforza S, Sayar R, Seo Y, Mejri M, et al. Understanding the Effects of Genotype, Growing Year, and Breeding on Tunisian Durum Wheat Allergenicity. 1. The Baker's Asthma Case. J Agric Food Chem. 2017;65:5831-5836 pubmed publisher
    ..The CM3 allergenic proteins were found to significantly vary among studied genotypes, as confirmed by genetic variability, coefficient of variance, heritability, and genetic advance...
  39. Hischenhuber C, Crevel R, Jarry B, Maki M, Moneret Vautrin D, Romano A, et al. Review article: safe amounts of gluten for patients with wheat allergy or coeliac disease. Aliment Pharmacol Ther. 2006;23:559-75 pubmed
    ..Available data suggest that a maximum gluten content for 'gluten-free' foods could be set, which protects both wheat allergy sufferers and coeliac patients...
  40. Nilsson N, Nilsson C, Hedlin G, Johansson S, Borres M, Nopp A. Combining analyses of basophil allergen threshold sensitivity, CD-sens, and IgE antibodies to hydrolyzed wheat, ?-5 gliadin and timothy grass enhances the prediction of wheat challenge outcome. Int Arch Allergy Immunol. 2013;162:50-7 pubmed publisher
  41. Joshi P, Mofidi S, Sicherer S. Interpretation of commercial food ingredient labels by parents of food-allergic children. J Allergy Clin Immunol. 2002;109:1019-21 pubmed
    ..Complex ingredient terminology (eg, casein and whey for milk) and label ambiguities (eg, natural flavor and may contain peanut ) might compromise the ability of patients/parents to determine the safety of particular products...
  42. Kohno K, Matsuo H, Takahashi H, Niihara H, Chinuki Y, Kaneko S, et al. Serum gliadin monitoring extracts patients with false negative results in challenge tests for the diagnosis of wheat-dependent exercise-induced anaphylaxis. Allergol Int. 2013;62:229-38 pubmed publisher
    ..Based on this knowledge, we sought to extract the patients with false negative results in the challenge tests of WDEIA...
  43. Lauriere M, Pecquet C, Bouchez Mahiout I, Snégaroff J, Bayrou O, Raison Peyron N, et al. Hydrolysed wheat proteins present in cosmetics can induce immediate hypersensitivities. Contact Dermatitis. 2006;54:283-9 pubmed
    ..The aggregation of peptide bearing these epitopes and others created by hydrolysis, along with the increased solubility and the route of exposure, are possible factors of the allergenicity of HWP...
  44. Hoffenberg E, Liu E. Celiac disease for the allergist: who and how to screen. Allergy Asthma Proc. 2007;28:20-4 pubmed
    ..Current understanding of the pathogenesis and epidemiology of celiac disease is reviewed. Issues of screening and genetic testing are discussed and current controversies and additional resources are highlighted...
  45. Lauriere M, Pecquet C, Boulenc E, Bouchez Mahiout I, Snegaroff J, Choudat D, et al. Genetic differences in omega-gliadins involved in two different immediate food hypersensitivities to wheat. Allergy. 2007;62:890-6 pubmed
    ..It is not known if they react with omega5-gliadins, the major allergens in wheat dependant exercise-induced food anaphylaxis (WDEIA), encoded on wheat chromosomes 1B...
  46. Mehta G, Taslaq S, Littleford S, Bansi D, Thillainayagam A. The changing face of coeliac disease. Br J Hosp Med (Lond). 2008;69:84-7 pubmed
    ..This article summarizes advances in diagnosis and innovations in therapy...
  47. Sotkovský P, Sklenar J, Halada P, Cinova J, Setinová I, Kainarová A, et al. A new approach to the isolation and characterization of wheat flour allergens. Clin Exp Allergy. 2011;41:1031-43 pubmed publisher
    ..The incidence of food allergy to wheat is increasing. Its diagnosis depends on the purity of major allergens and their inclusion in tests. Isolation and characterization of wheat allergens are therefore of utmost importance...
  48. Mamone G, Picariello G, Addeo F, Ferranti P. Proteomic analysis in allergy and intolerance to wheat products. Expert Rev Proteomics. 2011;8:95-115 pubmed publisher
  49. Ogden J, Leftwich J, Nelson M. The development and evaluation of a nurse led food intolerance clinic in primary care. Patient Educ Couns. 2011;85:e1-5 pubmed publisher
    ..To develop a clinic for patients who believe they have a food intolerance that could be administered by practice nurses with minimal experience of dietary change or food intolerance...
  50. de Angelis M, Rizzello C, Scala E, De Simone C, Farris G, Turrini F, et al. Probiotic preparation has the capacity to hydrolyze proteins responsible for wheat allergy. J Food Prot. 2007;70:135-44 pubmed
    ..The IgE-binding proteins that persisted in the bread made with VSL#3 were completely degraded by pepsin and pancreatin...
  51. Choudat D. [Diagnosis of respiratory allergy to wheat flour by specific provocation tests]. Eur Ann Allergy Clin Immunol. 2004;36:92-3 pubmed
  52. Otsuji K, Futamura M, Kando N, Hayashi K, Ito K. [Clinical evaluation of ?-5 gliadin-specific IgE test]. Arerugi. 2011;60:971-82 pubmed
    ..To reveal the clinical utility of an IgE test specific to ?-5 gliadin in the diagnosis of immediate-type wheat allergy...
  53. Kohno K, Takahashi H, Endo T, Matsuo H, Shiwaku K, Morita E. Characterization of a hypoallergenic wheat line lacking ?-5 gliadin. Allergol Int. 2016;65:400-405 pubmed publisher
    ..The use of the wheat products of the 1BS-18 line in daily life may provide a feasible solution for the onset of wheat allergy. ..