peanut hypersensitivity

Summary

Summary: Allergic reaction to peanuts that is triggered by the immune system.

Top Publications

  1. van Wijk F, Hoeks S, Nierkens S, Koppelman S, van Kooten P, Boon L, et al. CTLA-4 signaling regulates the intensity of hypersensitivity responses to food antigens, but is not decisive in the induction of sensitization. J Immunol. 2005;174:174-9 pubmed
    ..Furthermore, these data indicate that a profoundly Th2-biased cytokine environment is insufficient to induce allergic responses against dietary Ag...
  2. Peeters K, Koppelman S, Penninks A, Lebens A, Bruijnzeel Koomen C, Hefle S, et al. Clinical relevance of sensitization to lupine in peanut-sensitized adults. Allergy. 2009;64:549-55 pubmed publisher
    ..Furthermore, to determine the eliciting dose (ED) for lupine using double-blind placebo-controlled food challenges (DBPCFC)...
  3. Zhang T, Pan W, Takebe M, Schofield B, Sampson H, Li X. Therapeutic effects of a fermented soy product on peanut hypersensitivity is associated with modulation of T-helper type 1 and T-helper type 2 responses. Clin Exp Allergy. 2008;38:1808-18 pubmed publisher
    ..ImmuBalance is a koji fungus (Aspergillus oryzae) and lactic acid fermented soybean product. This unique production process is believed to create a food supplement that helps to induce or maintain normal immune response...
  4. Ho M, Wong W, Heine R, Hosking C, Hill D, Allen K. Early clinical predictors of remission of peanut allergy in children. J Allergy Clin Immunol. 2008;121:731-6 pubmed publisher
    ..Understanding predictors of clinical remission would assist in clinical management of peanut allergy...
  5. Khodoun M, Strait R, Orekov T, Hogan S, Karasuyama H, Herbert D, et al. Peanuts can contribute to anaphylactic shock by activating complement. J Allergy Clin Immunol. 2009;123:342-51 pubmed publisher
    ..Resistance to digestion and dendritic cell activation by the major peanut allergen Ara h 1 are reported to contribute to its allergenicity...
  6. Eller E, Hansen T, Bindslev Jensen C. Clinical thresholds to egg, hazelnut, milk and peanut: results from a single-center study using standardized challenges. Ann Allergy Asthma Immunol. 2012;108:332-6 pubmed publisher
    ..Large studies of individual thresholds and risk profiles for foods are sparse. Previous reports indicate that thresholds adjusted for the protein content in foods would be comparable...
  7. Glaspole I, de Leon M, Prickett S, O Hehir R, Rolland J. Clinical allergy to hazelnut and peanut: identification of T cell cross-reactive allergens. Int Arch Allergy Immunol. 2011;155:345-54 pubmed publisher
    ..Currently there is no cure. While co-allergy to peanut and tree nuts is a common clinical observation, and IgE cross-reactivity between peanut and tree nuts is reported, T cell cross-reactivity is poorly defined...
  8. Shek L, Cabrera Morales E, Soh S, Gerez I, Ng P, Yi F, et al. A population-based questionnaire survey on the prevalence of peanut, tree nut, and shellfish allergy in 2 Asian populations. J Allergy Clin Immunol. 2010;126:324-31, 331.e1-7 pubmed publisher
    ..There has been a substantial increase in the prevalence of peanut and tree nut allergy in Western populations in the last 2 decades. However, there is an impression that peanut and tree nut allergy is relatively uncommon in Asia...
  9. Venter C, Hasan Arshad S, Grundy J, Pereira B, Bernie Clayton C, Voigt K, et al. Time trends in the prevalence of peanut allergy: three cohorts of children from the same geographical location in the UK. Allergy. 2010;65:103-8 pubmed publisher

More Information

Publications62

  1. Vadas P, Gold M, Perelman B, Liss G, Lack G, Blyth T, et al. Platelet-activating factor, PAF acetylhydrolase, and severe anaphylaxis. N Engl J Med. 2008;358:28-35 pubmed publisher
    ..The roles of PAF and PAF acetylhydrolase, the enzyme that inactivates PAF, in anaphylaxis in humans have not been reported...
  2. Yu J, Kagan R, Verreault N, Nicolas N, Joseph L, St Pierre Y, et al. Accidental ingestions in children with peanut allergy. J Allergy Clin Immunol. 2006;118:466-72 pubmed
    ..Accidental exposure to peanut has been reported to occur frequently. Total avoidance of peanut is difficult because of its widespread use, manufacturing and labeling errors, utensil contamination, and label misinterpretation...
  3. Eller E, Bindslev Jensen C. Clinical value of component-resolved diagnostics in peanut-allergic patients. Allergy. 2013;68:190-4 pubmed publisher
    ..IgE toward specific peanut protein components has been reported to be of value, but data on correlation with clinical data are sparse. Our aim was to correlate IgE values with the outcome of peanut challenges...
  4. Chiang W, Pons L, Kidon M, Liew W, Goh A, Wesley Burks A. Serological and clinical characteristics of children with peanut sensitization in an Asian community. Pediatr Allergy Immunol. 2010;21:e429-38 pubmed publisher
    ..To review the clinical presentation of Asian children with peanut hypersensitivity and measure their IgE responses to major peanut allergens...
  5. Jensen L, Pedersen M, Skov P, Poulsen L, Bindslev Jensen C, Andersen S, et al. Peanut cross-reacting allergens in seeds and sprouts of a range of legumes. Clin Exp Allergy. 2008;38:1969-77 pubmed publisher
    ..Recently, peanut-allergic patients have reported symptoms upon ingestion of bean sprouts produced from various legumes...
  6. Lin J, Bruni F, Fu Z, Maloney J, Bardina L, Boner A, et al. A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarray immunoassay. J Allergy Clin Immunol. 2012;129:1321-1328.e5 pubmed publisher
    ..A laboratory test that could accurately diagnose symptomatic peanut allergy would greatly facilitate clinical practice...
  7. Leitch I, Walker M, Davey R. Food allergy: gambling your life on a take-away meal. Int J Environ Health Res. 2005;15:79-87 pubmed
    ..It is important for food allergy sufferers and their medical advisers to be made aware of the limitations of avoidance advice and that false assurances persist of the absence of peanut protein in takeaway foods...
  8. Nicolaou N, Poorafshar M, Murray C, Simpson A, Winell H, Kerry G, et al. Allergy or tolerance in children sensitized to peanut: prevalence and differentiation using component-resolved diagnostics. J Allergy Clin Immunol. 2010;125:191-7.e1-13 pubmed publisher
    ..Not all peanut-sensitized children develop allergic reactions on exposure...
  9. Asarnoj A, Movérare R, Ostblom E, Poorafshar M, Lilja G, Hedlin G, et al. IgE to peanut allergen components: relation to peanut symptoms and pollen sensitization in 8-year-olds. Allergy. 2010;65:1189-95 pubmed publisher
    ..The aim was to investigate IgE reactivity to peanut allergen components in children from a birch-rich region in relation to pollen sensitization and peanut symptoms...
  10. Sun J, Arias K, Alvarez D, Fattouh R, Walker T, Goncharova S, et al. Impact of CD40 ligand, B cells, and mast cells in peanut-induced anaphylactic responses. J Immunol. 2007;179:6696-703 pubmed
    ..Assessment of peanut hypersensitivity reactions was performed clinically and biologically...
  11. Cardoso C, Teixeira G, Provinciatto P, Godoi D, Ferreira B, Milanezi C, et al. Modulation of mucosal immunity in a murine model of food-induced intestinal inflammation. Clin Exp Allergy. 2008;38:338-49 pubmed
  12. Roberts G, Lack G. Diagnosing peanut allergy with skin prick and specific IgE testing. J Allergy Clin Immunol. 2005;115:1291-6 pubmed
    ..Food allergy is common in childhood. It has been suggested that the magnitude of a skin prick test or specific IgE result can improve diagnostic usefulness, but this has been addressed in only a few tertiary challenge-based studies...
  13. Leftwich J, Barnett J, Muncer K, Shepherd R, Raats M, Hazel Gowland M, et al. The challenges for nut-allergic consumers of eating out. Clin Exp Allergy. 2011;41:243-9 pubmed publisher
    ..For individuals with a nut allergy, the avoidance of allergens is particularly challenging in situations where they are not preparing their own food. Many allergic reactions occur when eating outside the home...
  14. Ross M, Ferguson M, Street D, Klontz K, Schroeder T, Luccioli S. Analysis of food-allergic and anaphylactic events in the National Electronic Injury Surveillance System. J Allergy Clin Immunol. 2008;121:166-71 pubmed publisher
    ..The National Electronic Injury Surveillance System (NEISS) captures a nationally representative probability sample from hospital emergency departments (EDs) in the United States...
  15. Palmer G, Dibbern D, Burks A, Bannon G, Bock S, Porterfield H, et al. Comparative potency of Ara h 1 and Ara h 2 in immunochemical and functional assays of allergenicity. Clin Immunol. 2005;115:302-12 pubmed
    ..This finding is different from what was predicted based on immunoblots or with the ImmunoCap assay...
  16. Sicherer S, Sampson H. Peanut allergy: emerging concepts and approaches for an apparent epidemic. J Allergy Clin Immunol. 2007;120:491-503; quiz 504-5 pubmed
    ..Among the therapeutic strategies reviewed are sublingual and oral immunotherapy, anti-IgE, Chinese herbal medicine, and vaccine strategies...
  17. Otsu K, Dreskin S. Peanut allergy: an evolving clinical challenge. Discov Med. 2011;12:319-28 pubmed
    ..This article will review the epidemiology, pathogenesis, and clinical features of peanut allergy and discuss future possibilities in diagnostic and therapeutic modalities...
  18. Frick O, Teuber S, Buchanan B, Morigasaki S, Umetsu D. Allergen immunotherapy with heat-killed Listeria monocytogenes alleviates peanut and food-induced anaphylaxis in dogs. Allergy. 2005;60:243-50 pubmed
    ..We asked if such treatment could decrease established peanut-induced anaphylaxis or cow's milk-induced food allergy in highly food-allergic dogs...
  19. Arias K, Baig M, Colangelo M, Chu D, Walker T, Goncharova S, et al. Concurrent blockade of platelet-activating factor and histamine prevents life-threatening peanut-induced anaphylactic reactions. J Allergy Clin Immunol. 2009;124:307-14, 314.e1-2 pubmed publisher
    ..Fatality registries place peanut as the most common culprit of fatal and near-fatal reactions in North America. Because prophylaxis and treatment have advanced little in recent years, it is imperative to evaluate novel therapies...
  20. Osborne N, Koplin J, Martin P, Gurrin L, Lowe A, Matheson M, et al. Prevalence of challenge-proven IgE-mediated food allergy using population-based sampling and predetermined challenge criteria in infants. J Allergy Clin Immunol. 2011;127:668-76.e1-2 pubmed publisher
    ..Several indicators suggest that food allergy in infants is common and possibly increasing. Few studies have used oral food challenge to measure this phenomenon at the population level...
  21. Rosenfeld L, Shreffler W, Bardina L, Niggemann B, Wahn U, Sampson H, et al. Walnut allergy in peanut-allergic patients: significance of sequential epitopes of walnut homologous to linear epitopes of Ara h 1, 2 and 3 in relation to clinical reactivity. Int Arch Allergy Immunol. 2012;157:238-45 pubmed publisher
    ..Therefore, we analyzed the binding of specific IgE antibodies to sequential epitopes of peanut and walnut in peanut-allergic patients with and without walnut allergy...
  22. Hazebrouck S, Guillon B, Drumare M, Paty E, Wal J, Bernard H. Trypsin resistance of the major peanut allergen Ara h 6 and allergenicity of the digestion products are abolished after selective disruption of disulfide bonds. Mol Nutr Food Res. 2012;56:548-57 pubmed publisher
    ..Five disulfide bridges (DB) stabilize Ara h 6 overall structure and their influence on the trypsin resistance and on the allergenicity of the digestion products was investigated...
  23. Clark A, Islam S, King Y, Deighton J, Anagnostou K, Ewan P. Successful oral tolerance induction in severe peanut allergy. Allergy. 2009;64:1218-20 pubmed publisher
    ..Peanut allergy is common, potentially severe and rarely resolves causing impaired quality of life. No disease-modifying treatment exists and there is therefore a need to develop a therapeutic intervention...
  24. Fox A, Sasieni P, Du Toit G, Syed H, Lack G. Household peanut consumption as a risk factor for the development of peanut allergy. J Allergy Clin Immunol. 2009;123:417-23 pubmed publisher
    ..Most children with peanut allergy (PA) react on first known oral exposure to peanut. Recent data suggest cutaneous exposure as a route of sensitization...
  25. Ben Shoshan M, Kagan R, Alizadehfar R, Joseph L, Turnbull E, St Pierre Y, et al. Is the prevalence of peanut allergy increasing? A 5-year follow-up study in children in Montreal. J Allergy Clin Immunol. 2009;123:783-8 pubmed publisher
    ..Studies suggest that peanut allergy prevalence might be increasing, but these results have not yet been substantiated...
  26. Astier C, Morisset M, Roitel O, Codreanu F, Jacquenet S, Franck P, et al. Predictive value of skin prick tests using recombinant allergens for diagnosis of peanut allergy. J Allergy Clin Immunol. 2006;118:250-6 pubmed
    ..Recombinant DNA technology allows production of pure biochemically characterized proteins. Their usefulness for peanut allergy diagnosis is not established...
  27. De Leon M, Drew A, Glaspole I, Suphioglu C, O Hehir R, Rolland J. IgE cross-reactivity between the major peanut allergen Ara h 2 and tree nut allergens. Mol Immunol. 2007;44:463-71 pubmed
    ..This indicates that the major peanut allergen, Ara h 2, shares common IgE-binding epitopes with almond and Brazil nut allergens, which may contribute to the high incidence of tree nut sensitisation in peanut allergic individuals...
  28. Adel Patient K, Ah Leung S, Bernard H, Durieux Alexandrenne C, Creminon C, Wal J. Oral sensitization to peanut is highly enhanced by application of peanut extracts to intact skin, but is prevented when CpG and cholera toxin are added. Int Arch Allergy Immunol. 2007;143:10-20 pubmed
    ..However, non-invasive ways of administration, especially in peanut-allergic patients, should be explored...
  29. Glaumann S, Nopp A, Johansson S, Rudengren M, Borres M, Nilsson C. Basophil allergen threshold sensitivity, CD-sens, IgE-sensitization and DBPCFC in peanut-sensitized children. Allergy. 2012;67:242-7 pubmed publisher
    ..The aim of the study was to evaluate the basophil allergen threshold sensitivity (CD-sens) and antibodies to peanut allergen components in relation to DBPCFC in the diagnoses of peanut allergy in children...
  30. Marsh J, Rigby N, Wellner K, Reese G, Knulst A, Akkerdaas J, et al. Purification and characterisation of a panel of peanut allergens suitable for use in allergy diagnosis. Mol Nutr Food Res. 2008;52 Suppl 2:S272-85 pubmed publisher
    ..Preliminary IgE binding studies of the purified allergens confirmed that they retained their immunological properties indicating their suitability for use in allergy diagnosis...
  31. Hourihane J, Grimshaw K, Lewis S, Briggs R, Trewin J, King R, et al. Does severity of low-dose, double-blind, placebo-controlled food challenges reflect severity of allergic reactions to peanut in the community?. Clin Exp Allergy. 2005;35:1227-33 pubmed
    ..The severity of allergic reactions to food appears to be affected by many interacting factors. It is uncertain whether challenge-based reactions reflect the severity of past reactions or can predict future risk...
  32. Delong J, Simpson K, Wambre E, James E, Robinson D, Kwok W. Ara h 1-reactive T cells in individuals with peanut allergy. J Allergy Clin Immunol. 2011;127:1211-8.e3 pubmed publisher
    ..Effective immunotherapy for peanut allergy is hampered by a lack of understanding of peanut-reactive CD4(+) T cells...
  33. Flinterman A, Knol E, Lencer D, Bardina L, Den Hartog Jager C, Lin J, et al. Peanut epitopes for IgE and IgG4 in peanut-sensitized children in relation to severity of peanut allergy. J Allergy Clin Immunol. 2008;121:737-743.e10 pubmed publisher
    ..Better understanding of the relationship between antibody response to peanut and clinical sensitivity might lead to more accurate prognostication...
  34. Summers C, Pumphrey R, Woods C, McDowell G, Pemberton P, Arkwright P. Factors predicting anaphylaxis to peanuts and tree nuts in patients referred to a specialist center. J Allergy Clin Immunol. 2008;121:632-638.e2 pubmed publisher
    ..Other than patients with coexisting asthma, it is currently not possible to predict which patients are most likely to develop severe reactions...
  35. Mittag D, Akkerdaas J, Ballmer Weber B, Vogel L, Wensing M, Becker W, et al. Ara h 8, a Bet v 1-homologous allergen from peanut, is a major allergen in patients with combined birch pollen and peanut allergy. J Allergy Clin Immunol. 2004;114:1410-7 pubmed
    ..We recently described patients with soybean allergy mainly mediated by cross-reactivity to birch pollen allergens. A majority of those patients were reported to have peanut allergy...
  36. Arnold D, Blajchman M, DiTomasso J, Kulczycki M, Keith P. Passive transfer of peanut hypersensitivity by fresh frozen plasma. Arch Intern Med. 2007;167:853-4 pubmed
  37. Hefle S, Furlong T, Niemann L, Lemon Mule H, Sicherer S, Taylor S. Consumer attitudes and risks associated with packaged foods having advisory labeling regarding the presence of peanuts. J Allergy Clin Immunol. 2007;120:171-6 pubmed
    ..Foods with advisory labeling (eg, "may contain") are increasingly prevalent. Consumers with food allergies might ignore advisory labeling advice...
  38. Varshney P, Jones S, Scurlock A, Perry T, Kemper A, Steele P, et al. A randomized controlled study of peanut oral immunotherapy: clinical desensitization and modulation of the allergic response. J Allergy Clin Immunol. 2011;127:654-60 pubmed publisher
    ..Open-label oral immunotherapy (OIT) protocols have been used to treat small numbers of patients with peanut allergy. Peanut OIT has not been evaluated in double-blind, placebo-controlled trials...
  39. Barnett J, Leftwich J, Muncer K, Grimshaw K, Shepherd R, Raats M, et al. How do peanut and nut-allergic consumers use information on the packaging to avoid allergens?. Allergy. 2011;66:969-78 pubmed publisher
    ..We aimed to understand the complex risk assessment decisions made by peanut and nut-allergic adults when purchasing food, with particular reference to use of printed package information...
  40. Blumchen K, Ulbricht H, Staden U, Dobberstein K, Beschorner J, de Oliveira L, et al. Oral peanut immunotherapy in children with peanut anaphylaxis. J Allergy Clin Immunol. 2010;126:83-91.e1 pubmed publisher
    ..The only treatment option for peanut allergy is strict avoidance...
  41. Fischer R, McGhee J, Vu H, Atkinson T, Jackson R, Tome D, et al. Oral and nasal sensitization promote distinct immune responses and lung reactivity in a mouse model of peanut allergy. Am J Pathol. 2005;167:1621-30 pubmed
    ..In summary, both oral and nasal peanut sensitization prime mice for airway hyperreactivity, but the initial mucosal route of sensitization influences the nature of lung inflammatory responses to peanut and unrelated allergens...
  42. Lehmann K, Schweimer K, Reese G, Randow S, Suhr M, Becker W, et al. Structure and stability of 2S albumin-type peanut allergens: implications for the severity of peanut allergic reactions. Biochem J. 2006;395:463-72 pubmed
    ..The extreme immunological stability of the core structures of Ara h 2 and Ara h 6 provides an explanation for the persistence of the allergenic potency even after food processing...
  43. Sicherer S, Muñoz Furlong A, Godbold J, Sampson H. US prevalence of self-reported peanut, tree nut, and sesame allergy: 11-year follow-up. J Allergy Clin Immunol. 2010;125:1322-6 pubmed publisher
    ..Allergy to peanuts and tree nuts (TNs) is the leading cause of fatal allergic reactions in the United States, and the prevalence appears to be increasing...
  44. van der Zee T, Dubois A, Kerkhof M, van der Heide S, Vlieg Boerstra B. The eliciting dose of peanut in double-blind, placebo-controlled food challenges decreases with increasing age and specific IgE level in children and young adults. J Allergy Clin Immunol. 2011;128:1031-6 pubmed publisher
    ..Therefore, in this study, the eliciting dose was used as a measure of clinical sensitivity...
  45. de Leon M, Rolland J, O Hehir R. The peanut allergy epidemic: allergen molecular characterisation and prospects for specific therapy. Expert Rev Mol Med. 2007;9:1-18 pubmed
    ..These include T-cell-epitope peptide and hypoallergenic mutant vaccines. Alternative routes of administration such as sublingual are also considered, and appropriate adjuvants for delivering effective treatments at these sites examined...
  46. Lauer I, Dueringer N, Pokoj S, Rehm S, Zoccatelli G, Reese G, et al. The non-specific lipid transfer protein, Ara h 9, is an important allergen in peanut. Clin Exp Allergy. 2009;39:1427-37 pubmed publisher
    ..The aim of this study was to characterize peanut nsLTP in comparison with peach nsLTP, Pru p 3, and assess its importance in peanut allergy...
  47. Flinterman A, Pasmans S, Hoekstra M, Meijer Y, van Hoffen E, Knol E, et al. Determination of no-observed-adverse-effect levels and eliciting doses in a representative group of peanut-sensitized children. J Allergy Clin Immunol. 2006;117:448-54 pubmed
    ..For future regulatory and industry guidelines, information on no-observed-adverse-effect levels (NOAELs) and eliciting doses (EDs) for allergenic foods is necessary...
  48. Yun J, Katelaris C. Food allergy in adolescents and adults. Intern Med J. 2009;39:475-8 pubmed publisher
    ..The management of food allergy consists of appropriate education regarding avoidance of implicated foods, modifying potential risk factors for anaphylaxis, such as asthma and prompt recognition and treatment of acute reactions...
  49. Klemans R, Otte D, Knol M, Knol E, Meijer Y, Gmelig Meyling F, et al. The diagnostic value of specific IgE to Ara h 2 to predict peanut allergy in children is comparable to a validated and updated diagnostic prediction model. J Allergy Clin Immunol. 2013;131:157-63 pubmed publisher
    ..A diagnostic prediction model for peanut allergy in children was recently published, using 6 predictors: sex, age, history, skin prick test, peanut specific immunoglobulin E (sIgE), and total IgE minus peanut sIgE...
  50. Hong X, Caruso D, Kumar R, Liu R, Liu X, Wang G, et al. IgE, but not IgG4, antibodies to Ara h 2 distinguish peanut allergy from asymptomatic peanut sensitization. Allergy. 2012;67:1538-46 pubmed publisher
    ..This study is aimed at evaluating whether the component-resolved diagnostic (CRD) IgE and IgG4 tests can (i) distinguish PA from asymptomatic peanut sensitization (PS) and (ii) differentiate anaphylactic from nonanaphylactic PA...
  51. Mueller G, Gosavi R, Pomés A, Wünschmann S, Moon A, London R, et al. Ara h 2: crystal structure and IgE binding distinguish two subpopulations of peanut allergic patients by epitope diversity. Allergy. 2011;66:878-85 pubmed publisher
    ..Residues involved in the epitope(s) are suggested by the crystal structure. The MBP--Ara h 2 fusion constructs will be useful to further elucidate the relevance of certain epitopes to peanut allergy. ..
  52. De Leon M, Drew A, Glaspole I, Suphioglu C, Rolland J, O Hehir R. Functional analysis of cross-reactive immunoglobulin E antibodies: peanut-specific immunoglobulin E sensitizes basophils to tree nut allergens. Clin Exp Allergy. 2005;35:1056-64 pubmed
    ..It is, however, unclear whether these cross-reactive IgE antibodies are involved in effector-cell activation...
  53. Palmer K, Burks W. Current developments in peanut allergy. Curr Opin Allergy Clin Immunol. 2006;6:202-6 pubmed
    ..Our objective is to highlight recent advances in the immunology and treatment of peanut allergy...