nut hypersensitivity

Summary

Summary: Allergic reaction to tree nuts that is triggered by the immune system.

Top Publications

  1. Akeson N, Worth A, Sheikh A. The psychosocial impact of anaphylaxis on young people and their parents. Clin Exp Allergy. 2007;37:1213-20 pubmed
    ..A pre-requisite for effective supported self-management of young people with anaphylaxis is a better understanding of the factors that contribute to risk-taking behaviour...
  2. Noimark L, Gardner J, Warner J. Parents' attitudes when purchasing products for children with nut allergy: a UK perspective. Pediatr Allergy Immunol. 2009;20:500-4 pubmed publisher
    ..Further tightening of labelling legislation and improved education would help to decrease the risk of anaphylaxis...
  3. Cummings A, Knibb R, Erlewyn Lajeunesse M, King R, Roberts G, Lucas J. Management of nut allergy influences quality of life and anxiety in children and their mothers. Pediatr Allergy Immunol. 2010;21:586-94 pubmed publisher
    ..Prescribing auto-injectors is associated with reduced anxiety for food allergic children and their mothers, but is not associated with improved adherence with medical management or reduced risk-taking behavior...
  4. Sicherer S, Muñoz Furlong A, Godbold J, Sampson H. US prevalence of self-reported peanut, tree nut, and sesame allergy: 11-year follow-up. J Allergy Clin Immunol. 2010;125:1322-6 pubmed publisher
    ..Allergy to peanuts and tree nuts (TNs) is the leading cause of fatal allergic reactions in the United States, and the prevalence appears to be increasing...
  5. Sicherer S, Muñoz Furlong A, Sampson H. Prevalence of peanut and tree nut allergy in the United States determined by means of a random digit dial telephone survey: a 5-year follow-up study. J Allergy Clin Immunol. 2003;112:1203-7 pubmed
    ..Allergy to peanuts and tree nuts (TNs) is the leading cause of fatal and near-fatal food allergic reactions. Peanut allergy appears to be increasing in prevalence...
  6. Barnett J, Leftwich J, Muncer K, Grimshaw K, Shepherd R, Raats M, et al. How do peanut and nut-allergic consumers use information on the packaging to avoid allergens?. Allergy. 2011;66:969-78 pubmed publisher
    ..We aimed to understand the complex risk assessment decisions made by peanut and nut-allergic adults when purchasing food, with particular reference to use of printed package information...
  7. Barnett J, Muncer K, Leftwich J, Shepherd R, Raats M, Gowland M, et al. Using 'may contain' labelling to inform food choice: a qualitative study of nut allergic consumers. BMC Public Health. 2011;11:734 pubmed publisher
    ..Neither food safety nor foods labelling legislation address this issue. The aim of this study is to understand how peanut and nut allergic adults interpret 'may contain' labelling and how they use this information when purchasing food...
  8. Summers C, Pumphrey R, Woods C, McDowell G, Pemberton P, Arkwright P. Factors predicting anaphylaxis to peanuts and tree nuts in patients referred to a specialist center. J Allergy Clin Immunol. 2008;121:632-638.e2 pubmed publisher
    ..Other than patients with coexisting asthma, it is currently not possible to predict which patients are most likely to develop severe reactions...
  9. Clark A, Ewan P. Good prognosis, clinical features, and circumstances of peanut and tree nut reactions in children treated by a specialist allergy center. J Allergy Clin Immunol. 2008;122:286-9 pubmed publisher
    ..The diagnosis of nut allergy causes anxiety. Few studies exist that estimate risk of reactions and inform management...

More Information

Publications62

  1. Leftwich J, Barnett J, Muncer K, Shepherd R, Raats M, Hazel Gowland M, et al. The challenges for nut-allergic consumers of eating out. Clin Exp Allergy. 2011;41:243-9 pubmed publisher
    ..For individuals with a nut allergy, the avoidance of allergens is particularly challenging in situations where they are not preparing their own food. Many allergic reactions occur when eating outside the home...
  2. Crespo J, James J, Fernandez Rodriguez C, Rodriguez J. Food allergy: nuts and tree nuts. Br J Nutr. 2006;96 Suppl 2:S95-102 pubmed
    ..Patients and families should be instructed how to recognise early symptoms of an allergic reaction and how to treat severe anaphylaxis promptly...
  3. Cabanillas B, Cheng H, Grimm C, Hurlburt B, Rodriguez J, Crespo J, et al. Pine nut allergy: clinical features and major allergens characterization. Mol Nutr Food Res. 2012;56:1884-93 pubmed publisher
    ..The aims of this study were to evaluate IgE-mediated hypersensitivity to pine nut with details of clinical reactions and to characterize major pine nut allergens...
  4. Knibb R, Ibrahim N, Stiefel G, Petley R, Cummings A, King R, et al. The psychological impact of diagnostic food challenges to confirm the resolution of peanut or tree nut allergy. Clin Exp Allergy. 2012;42:451-9 pubmed publisher
    ..We aimed to investigate effects of a food challenge on anxiety, stress and quality of life (QoL) in children and their mothers on the day of a food challenge to peanuts or nuts, and in the months following the challenge...
  5. Teuber S, Comstock S, Sathe S, Roux K. Tree nut allergy. Curr Allergy Asthma Rep. 2003;3:54-61 pubmed
    ..As with other severe food allergies, a recurrent problem in clinical management is the failure of physicians to prescribe self-injectable epinephrine to patients who are at risk of anaphylaxis...
  6. Barre A, Jacquet G, Sordet C, Culerrier R, Rouge P. Homology modelling and conformational analysis of IgE-binding epitopes of Ara h 3 and other legumin allergens with a cupin fold from tree nuts. Mol Immunol. 2007;44:3243-55 pubmed
  7. Roberts G. Anaphylaxis to foods. Pediatr Allergy Immunol. 2007;18:543-8 pubmed
    ..Managing children and teenagers with anaphylaxis is challenging due to the lack of available evidence that specific addresses these issue. The available evidence is presented and discussed...
  8. Kopper R, Odum N, Sen M, Helm R, Steve Stanley J, Wesley Burks A. Peanut protein allergens: gastric digestion is carried out exclusively by pepsin. J Allergy Clin Immunol. 2004;114:614-8 pubmed
    ..One estimate of the allergenic potential of a possible protein allergen is its stability under simulated gastric conditions...
  9. Panjari M, Koplin J, Dharmage S, Peters R, Gurrin L, Sawyer S, et al. Nut allergy prevalence and differences between Asian-born children and Australian-born children of Asian descent: a state-wide survey of children at primary school entry in Victoria, Australia. Clin Exp Allergy. 2016;46:602-9 pubmed publisher
    ..To further investigate the risk factors for nut allergy, we assessed the whole-of-state prevalence distribution of parent-reported nut allergy in 5-year-old children entering school...
  10. Pastorello E, Vieths S, Pravettoni V, Farioli L, Trambaioli C, Fortunato D, et al. Identification of hazelnut major allergens in sensitive patients with positive double-blind, placebo-controlled food challenge results. J Allergy Clin Immunol. 2002;109:563-70 pubmed
    ..No studies have reported hazelnut allergens recognized in patients with positive double-blind, placebo-controlled food challenge (DBPCFC) results or in patients allergic to hazelnut but not to birch...
  11. Flinterman A, Akkerdaas J, Knulst A, van Ree R, Pasmans S. Hazelnut allergy: from pollen-associated mild allergy to severe anaphylactic reactions. Curr Opin Allergy Clin Immunol. 2008;8:261-5 pubmed publisher
    ..There is a need to predict which subjects are at risk for severe reactions. In this study, possibilities for 'component-resolved diagnosis', based on sensitization to different allergens in hazelnut, are discussed...
  12. Faeste C, Holden L, Plassen C, Almli B. Sensitive time-resolved fluoroimmunoassay for the detection of hazelnut (Corylus avellana) protein traces in food matrices. J Immunol Methods. 2006;314:114-22 pubmed
    ..Of 100 randomly chosen retail food products in Norway labelled "may contain hazelnut", 36 contained <0.2 mg/kg and seven >10 mg/kg hazelnut protein, demonstrating how differently this precautionary label is used...
  13. De Knop K, Hagendorens M, Bridts C, Stevens W, Ebo D. Macadamia nut allergy: 2 case reports and a review of the literature. Acta Clin Belg. 2010;65:129-32 pubmed
    ..Temporal relationship between consumption of the nut strongly suggested the diagnosis. Clinical suspicion was supported by the presence of positive specific IgE and/or the positive skin test and/or and the basophil activation test...
  14. Pitchforth E, Weaver S, Willars J, Wawrzkowicz E, Luyt D, Dixon Woods M. A qualitative study of families of a child with a nut allergy. Chronic Illn. 2011;7:255-66 pubmed publisher
    ..The aim of this study was to explore, using qualitative methods, the experiences of children and their parents living with nut allergy...
  15. Masthoff L, Hoff R, Verhoeckx K, van Os Medendorp H, Michelsen Huisman A, Baumert J, et al. A systematic review of the effect of thermal processing on the allergenicity of tree nuts. Allergy. 2013;68:983-93 pubmed publisher
    ..Tree nuts are an important source of nutrition and increasingly consumed; however, processing methods are quite variable and data are currently lacking on the effects of processing on allergenicity...
  16. Estrada J, Gozalo F, Cecchini C, Casquete E. Contact urticaria from hops (Humulus lupulus) in a patient with previous urticaria-angioedema from peanut, chestnut and banana. Contact Dermatitis. 2002;46:127 pubmed
  17. Ahn K, Bardina L, Grishina G, Beyer K, Sampson H. Identification of two pistachio allergens, Pis v 1 and Pis v 2, belonging to the 2S albumin and 11S globulin family. Clin Exp Allergy. 2009;39:926-34 pubmed publisher
    ..IgE-mediated allergic reactions to pistachio appear to be occurring more frequently; however, little is known about its allergenic proteins...
  18. Ibañez M, Lombardero M, San Ireneo M, Muñoz M. Anaphylaxis induced by pine nuts in two young girls. Pediatr Allergy Immunol. 2003;14:317-9 pubmed
    ..Our patients were monosensitized to pine nut and the 17-kDa protein could be correlated with the severe clinical symptoms...
  19. Bukacel D, Bander R, Ibrahim R. Cross-reactivity between paclitaxel and hazelnut: a case report. J Oncol Pharm Pract. 2007;13:53-5 pubmed
    ..The hazelnut allergy may not be a nut-protein allergy at all, but rather an allergy to the components of paclitaxel that reside in the hazelnut itself...
  20. Hasegawa M, Inomata N, Yamazaki H, Morita A, Kirino M, Ikezawa Z. Clinical features of four cases with cashew nut allergy and cross-reactivity between cashew nut and pistachio. Allergol Int. 2009;58:209-15 pubmed publisher
    ..Few cases of cashew nut (CN) allergy have been reported in Japan. We evaluated the clinical features of 4 cases with CN allergy and investigated the allergens involved...
  21. Asero R, Arena A, Cervone M, Crivellaro M, Lodi Rizzini F, Longo R, et al. Heterogenity of IgE response to walnut and hazelnut in Italian allergic patients. Eur Ann Allergy Clin Immunol. 2013;45:160-6 pubmed
    ..The prevalence of IgE reactivity against genuine walnut and hazelnut allergens is poorly defined...
  22. Gillman A, Douglass J. What do asthmatics have to fear from food and additive allergy?. Clin Exp Allergy. 2010;40:1295-302 pubmed publisher
  23. Javed B, Padfield P, Sperrin M, Simpson A, Mills E. A protocol for a systematic review to identify allergenic tree nuts and the molecules responsible for their allergenic properties. Food Chem Toxicol. 2017;106:411-416 pubmed publisher
  24. Sten E, Stahl Skov P, Andersen S, Torp A, Olesen A, Bindslev Jensen U, et al. Allergenic components of a novel food, Micronesian nut Nangai (Canarium indicum), shows IgE cross-reactivity in pollen allergic patients. Allergy. 2002;57:398-404 pubmed
    ..We have evaluated the clinical and serological relevance of cross-reactivity between Nangai and pollen allergens...
  25. Galindo Bonilla P, Gomez Torrijos E, Borja Segade J, Feo Brito F, Lombardero Vega M. Allergy to tiger nut. Allergy. 2002;57:1083-4 pubmed
  26. Hansen K, Ballmer Weber B, Luttkopf D, Skov P, Wuthrich B, Bindslev Jensen C, et al. Roasted hazelnuts--allergenic activity evaluated by double-blind, placebo-controlled food challenge. Allergy. 2003;58:132-8 pubmed
    ..Symptoms upon ingestion are often confined to the mouth and throat, but severe systemic reactions have been described in some patients. The aim of the study was to evaluate the reduction in allergenicity by roasting of the nuts...
  27. Hand S, Darke C, Thompson J, Stingl C, Rolf S, Jones K, et al. Human leucocyte antigen polymorphisms in nut-allergic patients in South Wales. Clin Exp Allergy. 2004;34:720-4 pubmed
    ..Peanuts and tree nuts are among the most common foods provoking severe allergic reactions including fatal anaphylaxis. However, little is known of the underlying genetic and immunological mechanisms involved...
  28. Clark A, Ewan P. The development and progression of allergy to multiple nuts at different ages. Pediatr Allergy Immunol. 2005;16:507-11 pubmed
    ..This is related to increased duration of allergy and exposure to multiple nut types with age. Children with nut allergy should avoid all nut types from the onset...
  29. Verweij M, Hagendorens M, De Knop K, Bridts C, De Clerck L, Stevens W, et al. Young infants with atopic dermatitis can display sensitization to Cor a 9, an 11S legumin-like seed-storage protein from hazelnut (Corylus avellana). Pediatr Allergy Immunol. 2011;22:196-201 pubmed publisher
    ..The mechanism(s) of this early sensitization and its clinical significance remain elusive...
  30. Akkerdaas J, Wensing M, Asero R, Fernandez Rivas M, Rivas M, Knulst A, et al. IgE binding to pepsin-digested food extracts. Int Arch Allergy Immunol. 2005;138:203-8 pubmed
    ..However, for many foods, purified allergens are not (yet) available...
  31. Warmington E. Not allergic to life. Aust Fam Physician. 2008;37:199 pubmed
    ..A lot of things have changed over the 3 years since I first wrote for Australian Family Physician; but one thing remains... without prompt medical assistance I will die if I eat a nut...
  32. Bowman C, Selgrade M. Differences in allergenic potential of food extracts following oral exposure in mice reflect differences in digestibility: potential approaches to safety assessment. Toxicol Sci. 2008;102:100-9 pubmed
    ..Moreover, those foods containing digestion-resistant proteins provoke allergic responses in this model, supporting the current use of pepsin resistance in the decision tree for potential allergenicity assessment...
  33. Flinterman A, Hoekstra M, Meijer Y, van Ree R, Akkerdaas J, Bruijnzeel Koomen C, et al. Clinical reactivity to hazelnut in children: association with sensitization to birch pollen or nuts?. J Allergy Clin Immunol. 2006;118:1186-9 pubmed
  34. Panasoff J. Poppy seed anaphylaxis. J Investig Allergol Clin Immunol. 2008;18:224-5 pubmed
  35. Hallett R, Haapanen L, Teuber S. Food allergies and kissing. N Engl J Med. 2002;346:1833-4 pubmed
  36. Nitride C, Mamone G, Picariello G, Mills C, Nocerino R, Berni Canani R, et al. Proteomic and immunological characterization of a new food allergen from hazelnut (Corylus avellana). J Proteomics. 2013;86:16-26 pubmed publisher
    ..The structural characterization suggests that the new putative allergen is a divergent isoform of the hazelnut 11S globulin. These results provide a new platform for developing innovative diagnostic and therapeutic intervention plans...
  37. Comstock S, DeMera R, Vega L, Boren E, Deane S, Haapanen L, et al. Allergic reactions to peanuts, tree nuts, and seeds aboard commercial airliners. Ann Allergy Asthma Immunol. 2008;101:51-6 pubmed publisher
    ..Minimal data exist on the prevalence and characteristics of in-flight reactions to foods...
  38. Comstock S, Robotham J, Tawde P, Kshirsagar H, Sathe S, Roux K, et al. Immunoglobulin E-reactive proteins in cashew (Anacardium occidentale) apple juice concentrate. J Agric Food Chem. 2008;56:5977-82 pubmed publisher
    ..The cashew apple juice concentrate used in these studies contains proteins with IgE-reactive epitopes, including cashew nut legumin and vicilin. No IgE-binding peptides remained after 5 kDa filtration of the concentrate...
  39. Davis P, Jenab M, Vanden Heuvel J, Furlong T, Taylor S. Tree nut and peanut consumption in relation to chronic and metabolic diseases including allergy. J Nutr. 2008;138:1757S-1762S pubmed
    ..Ultimately, to maximize the positive benefits of nuts, the consumer must be provided with all the information required to make an informed choice...
  40. Worm M, Hompes S, Fiedler E, Illner A, Zuberbier T, Vieths S. Impact of native, heat-processed and encapsulated hazelnuts on the allergic response in hazelnut-allergic patients. Clin Exp Allergy. 2009;39:159-66 pubmed publisher
    ..Pollen-associated food allergy is common. However, systemic reactions or even life-threatening anaphylaxis are rare...
  41. Bohle B, Radakovics A, Luttkopf D, Jahn Schmid B, Vieths S, Ebner C. Characterization of the T cell response to the major hazelnut allergen, Cor a 1.04: evidence for a relevant T cell epitope not cross-reactive with homologous pollen allergens. Clin Exp Allergy. 2005;35:1392-9 pubmed
    ..g. apples, carrots and hazelnuts. In a high number of tree pollen-allergic individuals, this cross-reactivity causes clinical symptoms, commonly known as the 'birch-fruit-syndrome'...
  42. Parvataneni S, Gonipeta B, Tempelman R, Gangur V. Development of an adjuvant-free cashew nut allergy mouse model. Int Arch Allergy Immunol. 2009;149:299-304 pubmed publisher
    ..Cashew nut allergy is an emerging food allergy with a high risk of systemic anaphylaxis. Currently, an adjuvant-free animal model to study cashew nut allergy is not available...
  43. Teuber S, Beyer K. Peanut, tree nut and seed allergies. Curr Opin Allergy Clin Immunol. 2004;4:201-3 pubmed
  44. Wang F, Robotham J, Teuber S, Sathe S, Roux K. Ana o 2, a major cashew (Anacardium occidentale L.) nut allergen of the legumin family. Int Arch Allergy Immunol. 2003;132:27-39 pubmed
    ..Additional IgE-reactive cashew peptides of the legumin group and 2S albumin families have also been reported. Here, we attempt to clone, express and characterize a second major cashew allergen...
  45. Rosenfeld L, Shreffler W, Bardina L, Niggemann B, Wahn U, Sampson H, et al. Walnut allergy in peanut-allergic patients: significance of sequential epitopes of walnut homologous to linear epitopes of Ara h 1, 2 and 3 in relation to clinical reactivity. Int Arch Allergy Immunol. 2012;157:238-45 pubmed publisher
    ..Therefore, we analyzed the binding of specific IgE antibodies to sequential epitopes of peanut and walnut in peanut-allergic patients with and without walnut allergy...
  46. Phan T, Strasser S, Koorey D, McCaughan G, Rimmer J, Dunckley H, et al. Passive transfer of nut allergy after liver transplantation. Arch Intern Med. 2003;163:237-9 pubmed
    ..We therefore recommend that organ donors undergo screening for allergies, and that recipients be advised regarding allergen avoidance...
  47. Ebo D, Verweij M, Sabato V, Hagendorens M, Bridts C, De Clerck L. Hazelnut allergy: a multi-faced condition with demographic and geographic characteristics. Acta Clin Belg. 2012;67:317-21 pubmed
    ..04 and Bet v 1, the major allergen from birch (Betula verrucosa) pollen. In the absence of a cure, avoidance remains the key measure of effective management, particularly in those patients presenting with a severe form...
  48. Robotham J, Hoffman G, Teuber S, Beyer K, Sampson H, Sathe S, et al. Linear IgE-epitope mapping and comparative structural homology modeling of hazelnut and English walnut 11S globulins. Mol Immunol. 2009;46:2975-84 pubmed publisher
    ..These findings reveal structural features that may be important to allergenicity and cross-reactivity of this protein class...
  49. Enrique E, Pineda F, Malek T, Bartra J, Basagaña M, Tella R, et al. Sublingual immunotherapy for hazelnut food allergy: a randomized, double-blind, placebo-controlled study with a standardized hazelnut extract. J Allergy Clin Immunol. 2005;116:1073-9 pubmed
    ..Food allergy may be life-threatening, and patients affected need to receive accurate diagnoses and treatment. Hazelnut has often been implicated as responsible for allergic reactions, and trace quantities can induce systemic reactions...
  50. Greenhawt M, Macgillivray F, Batty G, Said M, Weiss C. International study of risk-mitigating factors and in-flight allergic reactions to peanut and tree nut. J Allergy Clin Immunol Pract. 2013;1:186-94 pubmed publisher
    ..Three studies have analyzed in-flight peanut/tree nut reactions, although the studies were conducted exclusively among Americans...
  51. Niggemann B, Reibel S, Hipler C, Wahn U. Anaphylactic reaction to lychee in a 12-year-old girl: cross-reactivity to latex?. Pediatr Allergy Immunol. 2002;13:64-7 pubmed
    ..In conclusion, it seems worthwhile considering the rare allergy to lychee in the case of unclear food-allergic reactions and lychee should be added to the list of foods cross-reacting with latex...
  52. Colver A, MacDougall C, Cant A. Food allergy in childhood. Arch Dis Child. 2003;88:742-3 pubmed
  53. Erdmann S, Heussen N, Moll Slodowy S, Merk H, Sachs B. CD63 expression on basophils as a tool for the diagnosis of pollen-associated food allergy: sensitivity and specificity. Clin Exp Allergy. 2003;33:607-14 pubmed
    ..Basophil activation is associated with the expression of CD63. Because allergens can induce basophil activation by cross-linking specific IgE, increased CD63 expression has been proposed as a novel in vitro test for immediate type allergy...