egg hypersensitivity

Summary

Summary: Allergic reaction to eggs that is triggered by the immune system.

Top Publications

  1. Allen C, Campbell D, Kemp A. Egg allergy: are all childhood food allergies the same?. J Paediatr Child Health. 2007;43:214-8 pubmed
    ..An understanding of the similarities and differences in these common food allergies of childhood is helpful in the management of these common and increasing problems...
  2. Yang M, Yang C, Mine Y. Multiple T cell epitope peptides suppress allergic responses in an egg allergy mouse model by the elicitation of forkhead box transcription factor 3- and transforming growth factor-beta-associated mechanisms. Clin Exp Allergy. 2010;40:668-78 pubmed publisher
    ..Peptide-based immunotherapy (PIT) represents an attractive approach for targeted interventions in immunological disorders, but has not been widely explored in the context of food allergy...
  3. Nowak Wegrzyn A, Sampson H. Future therapies for food allergies. J Allergy Clin Immunol. 2011;127:558-73; quiz 574-5 pubmed publisher
    ..The variety of strategies for treating food allergy increases the likelihood of success and gives hope that accomplishing an effective therapy for food allergy is within reach...
  4. Benhamou A, Zamora S, Eigenmann P. Correlation between specific immunoglobulin E levels and the severity of reactions in egg allergic patients. Pediatr Allergy Immunol. 2008;19:173-9 pubmed publisher
    ..18 and 11.00 (median 3.70) (p = 0.006). Our results show a correlation between IgE titres and the severity of the clinical reaction to egg. IgE titres may help to determine the potential risk of a reaction to eggs...
  5. Komata T, Soderstrom L, Borres M, Tachimoto H, Ebisawa M. The predictive relationship of food-specific serum IgE concentrations to challenge outcomes for egg and milk varies by patient age. J Allergy Clin Immunol. 2007;119:1272-4 pubmed
  6. Leonard S, Sampson H, Sicherer S, Noone S, Moshier E, Godbold J, et al. Dietary baked egg accelerates resolution of egg allergy in children. J Allergy Clin Immunol. 2012;130:473-80.e1 pubmed publisher
    ..Baked egg is tolerated by a majority of egg-allergic children...
  7. Boyano Martínez T, García Ara C, Díaz Pena J, Martín Esteban M. Prediction of tolerance on the basis of quantification of egg white-specific IgE antibodies in children with egg allergy. J Allergy Clin Immunol. 2002;110:304-9 pubmed
    ..However, there are few follow-up studies that determine the exact probability of tolerance to a given food or that analyze prognostic factors that can help us to understand the evolution of a child who begins life with a food allergy...
  8. Martos G, Lopez Exposito I, Bencharitiwong R, Berin M, Nowak Wegrzyn A. Mechanisms underlying differential food allergy response to heated egg. J Allergy Clin Immunol. 2011;127:990-7.e1-2 pubmed publisher
    ..Egg white proteins are usually subjected to heating, making them edible for the majority of children with egg allergy...
  9. Konstantinou G, Giavi S, Kalobatsou A, Vassilopoulou E, Douladiris N, Saxoni Papageorgiou P, et al. Consumption of heat-treated egg by children allergic or sensitized to egg can affect the natural course of egg allergy: hypothesis-generating observations. J Allergy Clin Immunol. 2008;122:414-5 pubmed publisher

More Information

Publications62

  1. Savage J, Matsui E, Skripak J, Wood R. The natural history of egg allergy. J Allergy Clin Immunol. 2007;120:1413-7 pubmed
    ..Egg allergy is very common, affecting 1% to 2% of children. It is generally thought that the majority of children with egg allergy develop tolerance in early childhood; however, this has not been examined in a large cohort with egg allergy...
  2. Patriarca G, Nucera E, Pollastrini E, Roncallo C, De Pasquale T, Lombardo C, et al. Oral specific desensitization in food-allergic children. Dig Dis Sci. 2007;52:1662-72 pubmed
  3. Reininger R, Exner H, Kuderna C, Rumpold H, Balic N, Valenta R, et al. Possible modes of allergen-specific sensitization and boosting in an atopic child. Int Arch Allergy Immunol. 2003;130:275-9 pubmed
  4. Escudero C, Quirce S, Fernandez Nieto M, Miguel J, Cuesta J, Sastre J. Egg white proteins as inhalant allergens associated with baker's asthma. Allergy. 2003;58:616-20 pubmed
    ..Bakery workers may develop IgE-mediated allergy to liquid and aerosolized hen's egg proteins that are commonly used in the baking and confectionery industries...
  5. Ando H, Movérare R, Kondo Y, Tsuge I, Tanaka A, Borres M, et al. Utility of ovomucoid-specific IgE concentrations in predicting symptomatic egg allergy. J Allergy Clin Immunol. 2008;122:583-8 pubmed publisher
    ..Children with allergy to raw egg white might tolerate low amounts of heated egg. Ovomucoid-specific IgE antibodies have been suggested to be predictors of whether children could tolerate heat-treated egg...
  6. Everberg H, Brostedt P, Oman H, Bohman S, Movérare R. Affinity purification of egg-white allergens for improved component-resolved diagnostics. Int Arch Allergy Immunol. 2011;154:33-41 pubmed publisher
    ..Commercially available preparations of the egg-white allergens, ovomucoid, ovalbumin, conalbumin and lysozyme, have been reported to contain impurities which interfere with accurate CRD...
  7. Kemp A, Allen C, Campbell D. Parental perceptions in egg allergy: does egg challenge make a difference?. Pediatr Allergy Immunol. 2009;20:648-53 pubmed publisher
    ..The greater certainty provided by the performance of a food challenge may be a positive outcome in both CP and CN children...
  8. Garcia Rodriguez R, Urra J, Feo Brito F, Galindo P, Borja J, Gomez E, et al. Oral rush desensitization to egg: efficacy and safety. Clin Exp Allergy. 2011;41:1289-96 pubmed publisher
    ..To solve these problems, some desensitization protocols have been described that are safe and effective, but only one study of a rush regimen for egg with a small patient sample has been published...
  9. Mankad V, Williams L, Lee L, LaBelle G, Anstrom K, Burks A. Safety of open food challenges in the office setting. Ann Allergy Asthma Immunol. 2008;100:469-74 pubmed publisher
    ..Open food challenges are a practical alternative to double-blind, placebo-controlled food challenges in confirming clinical sensitivity or tolerance to a food, and the risks associated with open challenges are unknown...
  10. Clark A, Islam S, King Y, Deighton J, Szun S, Anagnostou K, et al. A longitudinal study of resolution of allergy to well-cooked and uncooked egg. Clin Exp Allergy. 2011;41:706-12 pubmed publisher
    ..Egg allergy is common and although resolution to uncooked egg has been demonstrated, there is lack of evidence to guide reintroduction of well-cooked egg...
  11. Järvinen K, Beyer K, Vila L, Bardina L, Mishoe M, Sampson H. Specificity of IgE antibodies to sequential epitopes of hen's egg ovomucoid as a marker for persistence of egg allergy. Allergy. 2007;62:758-65 pubmed
    ..Approximately two-thirds of egg-allergic infants become tolerant within the first 5 years of life...
  12. Buchanan A, Green T, Jones S, Scurlock A, Christie L, Althage K, et al. Egg oral immunotherapy in nonanaphylactic children with egg allergy. J Allergy Clin Immunol. 2007;119:199-205 pubmed
    ..There is no current active treatment for food allergy. Traditional injection immunotherapy has been proved unsafe, and thus there is a need for other forms of immunotherapy...
  13. Des Roches A, Nguyen M, Paradis L, Primeau M, Singer S. Tolerance to cooked egg in an egg allergic population. Allergy. 2006;61:900-1 pubmed
  14. Burks A, Jones S, Wood R, Fleischer D, Sicherer S, Lindblad R, et al. Oral immunotherapy for treatment of egg allergy in children. N Engl J Med. 2012;367:233-43 pubmed publisher
    ..For egg allergy, dietary avoidance is the only currently approved treatment. We evaluated oral immunotherapy using egg-white powder for the treatment of children with egg allergy...
  15. Meglio P, Giampietro P, Carello R, Gabriele I, Avitabile S, Galli E. Oral food desensitization in children with IgE-mediated hen's egg allergy: a new protocol with raw hen's egg. Pediatr Allergy Immunol. 2013;24:75-83 pubmed publisher
    ..The protocol foresaw the egg reintroduction in the home setting...
  16. Smith M, Tourigny M, Noakes P, Thornton C, Tulic M, Prescott S. Children with egg allergy have evidence of reduced neonatal CD4(+)CD25(+)CD127(lo/-) regulatory T cell function. J Allergy Clin Immunol. 2008;121:1460-6, 1466.e1-7 pubmed publisher
    ..The role of regulatory T (Treg) cells in allergic predisposition is not known...
  17. D Urbano L, Pellegrino K, Artesani M, Donnanno S, Luciano R, Riccardi C, et al. Performance of a component-based allergen-microarray in the diagnosis of cow's milk and hen's egg allergy. Clin Exp Allergy. 2010;40:1561-70 pubmed publisher
    ..An ideal in vitro test should allow to avoid the FCT. Objective To assess the clinical performance of microarray for specific IgE (sIgE) detection in children with challenge-proven/excluded cow's milk (CM) or hen's egg (HE) allergy...
  18. Ahrens B, Lopes de Oliveira L, Schulz G, Borres M, Niggemann B, Wahn U, et al. The role of hen's egg-specific IgE, IgG and IgG4 in the diagnostic procedure of hen's egg allergy. Allergy. 2010;65:1554-7 pubmed publisher
    ..The aim of the study was to correlate HE-specific IgE, IgG and IgG4 levels with the outcome of double-blind, placebo-controlled food challenges (DBPCFC) in patients with suspected HE allergy to improve diagnostic procedures...
  19. Sicherer S, Wood R, Stablein D, Burks A, Liu A, Jones S, et al. Immunologic features of infants with milk or egg allergy enrolled in an observational study (Consortium of Food Allergy Research) of food allergy. J Allergy Clin Immunol. 2010;125:1077-1083.e8 pubmed publisher
    ..Immune features of infants with food allergy have not been delineated...
  20. Itoh N, Itagaki Y, Kurihara K. Rush specific oral tolerance induction in school-age children with severe egg allergy: one year follow up. Allergol Int. 2010;59:43-51 pubmed publisher
    ..A new type of treatment is long desired. The objectives of this study are to perform our rush SOTI for school-age patients with severe egg allergy, and to evaluate the safety and efficacy of this method for one year...
  21. Martínez Alonso J, Domínguez Ortega F, Fuentes Gonzalo M. [Angioedema due to sensitization to chicken meat]. Allergol Immunopathol (Madr). 2003;31:50-2 pubmed
    ..We report a patient with former history of hypersensitivity to egg who developed episodes of angioedema after ingestion of hen meat...
  22. Jacobsen B, Hoffmann Sommergruber K, Have T, Foss N, Briza P, Oberhuber C, et al. The panel of egg allergens, Gal d 1-Gal d 5: Their improved purification and characterization. Mol Nutr Food Res. 2008;52 Suppl 2:S176-85 pubmed publisher
    ..The allergen batches will be further used to set up allergen specific diagnostic assays and to screen a larger collection of patients' sera...
  23. Fuentes Aparicio V, Alonso Lebrero E, Zapatero L, Infante S, Lorente R, Ángeles Muñoz Fernández M, et al. Oral immunotherapy in hen's egg-allergic children increases a hypo-proliferative subset of CD4+ T cells that could constitute a marker of tolerance achievement. Pediatr Allergy Immunol. 2012;23:648-53 pubmed publisher
    ..Our purpose was to study which immune parameters are modified during the process of tolerance achievement with the goal of identifying markers of tolerance induction...
  24. Hasan S, Wells R, Davis C. Egg hypersensitivity in review. Allergy Asthma Proc. 2013;34:26-32 pubmed publisher
    b>Egg hypersensitivity is the second most common food allergy with a prevalence of up to 1.7% and the discovery of information about egg allergy is ongoing...
  25. Allen C, Kemp A, Campbell D. Dietary advice, dietary adherence and the acquisition of tolerance in egg-allergic children: a 5-yr follow-up. Pediatr Allergy Immunol. 2009;20:213-8 pubmed publisher
    ..Strict avoidance of egg and accidental ingestion of egg did not appear to influence the acquisition of tolerance...
  26. Tey D, Heine R. Egg allergy in childhood: an update. Curr Opin Allergy Clin Immunol. 2009;9:244-50 pubmed publisher
    ..In this article, we review the recent literature regarding the immunology, clinical presentation, diagnosis, management and natural history of egg allergy...
  27. Lemon Mule H, Sampson H, Sicherer S, Shreffler W, Noone S, Nowak Wegrzyn A. Immunologic changes in children with egg allergy ingesting extensively heated egg. J Allergy Clin Immunol. 2008;122:977-983.e1 pubmed publisher
    ..Prior studies have suggested that heated egg might be tolerated by some children with egg allergy...
  28. Clark A, Skypala I, Leech S, Ewan P, Dugue P, Brathwaite N, et al. British Society for Allergy and Clinical Immunology guidelines for the management of egg allergy. Clin Exp Allergy. 2010;40:1116-29 pubmed publisher
    ..The document encompasses epidemiology, risk factors, diagnosis, treatment, prognosis and co-morbid associations...
  29. Rona R, Keil T, Summers C, Gislason D, Zuidmeer L, Sodergren E, et al. The prevalence of food allergy: a meta-analysis. J Allergy Clin Immunol. 2007;120:638-46 pubmed
    ..There is uncertainty about the prevalence of food allergy in communities...
  30. Konstantinou G, Kim J. Paradigm shift in the management of milk and egg allergy: baked milk and egg diet. Immunol Allergy Clin North Am. 2012;32:151-64 pubmed publisher
    ..In this article, the authors review the important role of thermal processing on milk and egg proteins, which comprise the commonest food allergies in infancy and early childhood...
  31. Dang T, Tang M, Koplin J, Licciardi P, Eckert J, Tan T, et al. Characterization of plasma cytokines in an infant population cohort of challenge-proven food allergy. Allergy. 2013;68:1233-40 pubmed publisher
  32. Yavuz S, Sahiner U, Sekerel B, Tuncer A, Kalayci O, Sackesen C. Anaphylactic reactions to measles-mumps-rubella vaccine in three children with allergies to hen's egg and cow's milk. Acta Paediatr. 2011;100:e94-6 pubmed publisher
    ..Allergies to hen's egg and cow's milk are the most frequent food allergies in infancy and childhood. Current guidelines recommend safe administration of measles-mumps-rubella (MMR) vaccine in egg allergic patients...
  33. Suzuki K, Inoue R, Sakaguchi H, Aoki M, Kato Z, Kaneko H, et al. The correlation between ovomucoid-derived peptides, human leucocyte antigen class II molecules and T cell receptor-complementarity determining region 3 compositions in patients with egg-white allergy. Clin Exp Allergy. 2002;32:1223-30 pubmed
    ..Ovomucoid (OM) is one of the major allergens that is found in egg white...
  34. Ben Shoshan M, Lejtenyi C, Primeau M. The predilection of chickenpox exanthema to influenza vaccine injection site. Pediatr Dermatol. 2009;26:481-2 pubmed publisher
    ..Annual influenza immunization of children is highly recommended and is usually well tolerated. We report the first case of chickenpox exanthema localized to the influenza vaccination site in a boy with known egg allergy...
  35. Esposito S, Gasparini C, Martelli A, Zenga A, Tremolati E, Varin E, et al. Safe administration of an inactivated virosomal adjuvanted influenza vaccine in asthmatic children with egg allergy. Vaccine. 2008;26:4664-8 pubmed publisher
    ..The results showed the safety of the administration, and demonstrated that Inflexal V can be safely given without performing a vaccine skin test in children with any kind of egg allergy...
  36. Unsel M, Sin A, Ardeniz O, Erdem N, Ersoy R, Gulbahar O, et al. New onset egg allergy in an adult. J Investig Allergol Clin Immunol. 2007;17:55-8 pubmed
    ..Because egg allergy mainly affects children and symptoms frequently disappear with age, the late onset in this patient is rare...
  37. Weber P, Kratzin H, Brockow K, Ring J, Steinhart H, Paschke A. Lysozyme in wine: A risk evaluation for consumers allergic to hen's egg. Mol Nutr Food Res. 2009;53:1469-77 pubmed publisher
  38. Sai X, Zheng Y, Zhao J, Hao W. [A cross sectional survey on the prevalence of food intolerance and its determinants in Beijing, China]. Zhonghua Liu Xing Bing Xue Za Zhi. 2011;32:302-5 pubmed
    ..To study the prevalence of food intolerance among attendants in a general hospital and to learn its related determinants in Beijing, China...
  39. Schoetzau A, Filipiak Pittroff B, Franke K, Koletzko S, von Berg A, Gruebl A, et al. Effect of exclusive breast-feeding and early solid food avoidance on the incidence of atopic dermatitis in high-risk infants at 1 year of age. Pediatr Allergy Immunol. 2002;13:234-42 pubmed
    ..We conclude that in infants at atopic risk, exclusive breast-feeding for at least 4 months is effective in preventing AD in the first year of life...
  40. Dumortier B, Nosbaum A, Ponvert C, Nicolas J, Berard F. [Measles-Mumps-Rubella vaccination of an egg-allergic child sensitized to gelatin]. Arch Pediatr. 2013;20:867-70 pubmed publisher
    ..The MMR vaccine should be given and is well tolerated in patients with immediate-type egg hypersensitivity, even when gelatin sensitization is combined.
  41. Alessandri C, Calvani M. [Egg allergy]. Minerva Pediatr. 2006;58:167-82 pubmed
    ..From this review it is clear how egg allergic children can be vaccinated against measles-mumps rubella...
  42. Alessandri C, Calvani M, Rosengart L, Madella C. Anaphylaxis to quail egg. Allergy. 2005;60:128-9 pubmed
  43. Kulis M, Wesley Burks A. Oral immunotherapy for food allergy: clinical and preclinical studies. Adv Drug Deliv Rev. 2013;65:774-81 pubmed publisher
    ..With many clinical trials underway across the United States and other countries, and a growing pipeline of preclinical research with translational potential, there is great hope for a widely applicable food allergy treatment...
  44. Armentia A, Duenas Laita A, Pineda F, Herrero M, Martin B. Vinegar decreases allergenic response in lentil and egg food allergy. Allergol Immunopathol (Madr). 2010;38:74-7 pubmed publisher
    ..Antacid medication inhibits the digestion of dietary proteins and causes food allergy. A decrease of the gastric pH might enhance the function of digestion and reduce the risk of food allergy...
  45. Vazquez Ortiz M, Alvaro M, Piquer M, Dominguez O, Machinena A, Martin Mateos M, et al. Baseline specific IgE levels are useful to predict safety of oral immunotherapy in egg-allergic children. Clin Exp Allergy. 2014;44:130-41 pubmed publisher
    ..Oral immunotherapy (OIT) is a promising treatment for food allergy but dose-related reactions are common...
  46. Romeira A, Pires G, Gaspar A, Arêde C, Morais Almeida M, Rosado Pinto J. Egg allergy--to be or not to be boiled. Allergy. 2003;58:533-4 pubmed
  47. Osterballe M, Bindslev Jensen C. Threshold levels in food challenge and specific IgE in patients with egg allergy: is there a relationship?. J Allergy Clin Immunol. 2003;112:196-201 pubmed
    ..These investigations defined different levels of predictive values in different study populations and thus pointed toward the possibility of a certain level of specific IgE to egg white predicting a positive outcome in food challenge...
  48. Canani R, Ruotolo S, Auricchio L, Caldore M, Porcaro F, Manguso F, et al. Diagnostic accuracy of the atopy patch test in children with food allergy-related gastrointestinal symptoms. Allergy. 2007;62:738-43 pubmed
    ..Moreover, APTs containing purified food extracts have recently become available, but their diagnostic accuracy is largely undefined...
  49. Lunn M, Fausnight T. Hypersensitivity to total parenteral nutrition fat-emulsion component in an egg-allergic child. Pediatrics. 2011;128:e1025-8 pubmed publisher
    ..Although ingestion of egg lecithin in cooked food is generally tolerated by egg-allergic people, administration of intravenous egg-containing lipid emulsions may cause significant adverse reactions...
  50. Kemp A. Egg allergy. Pediatr Allergy Immunol. 2007;18:696-702 pubmed
    ..life-threatening reactions, with immunization with vaccines prepared in eggs, with the diagnosis of egg hypersensitivity as a cause of delayed exacerbations of eczema which can be non-IgE mediated, and in deciding whether a ..
  51. Krogulska A, Borowiec M, Polakowska E, Dynowski J, Młynarski W, Wasowska Królikowska K. FOXP3, IL-10, and TGF-? genes expression in children with IgE-dependent food allergy. J Clin Immunol. 2011;31:205-15 pubmed publisher
    ..The forkhead/winged-helix transcription factor box protein 3 (FOXP3) is considered the most reliable marker for Tregs...
  52. Jones S, Burks A, Keet C, Vickery B, Scurlock A, Wood R, et al. Long-term treatment with egg oral immunotherapy enhances sustained unresponsiveness that persists after cessation of therapy. J Allergy Clin Immunol. 2016;137:1117-1127.e10 pubmed publisher
    ..0002) over time and a lower median baseline ratio of egg-specific IgE to total IgE (1.1% vs 2.7%, P = .04). SU after eOIT is enhanced with longer duration of therapy and increases the likelihood of tolerating unbaked egg in the diet. ..
  53. Perkin M, Logan K, Tseng A, Raji B, Ayis S, Peacock J, et al. Randomized Trial of Introduction of Allergenic Foods in Breast-Fed Infants. N Engl J Med. 2016;374:1733-43 pubmed publisher
    ..We evaluated whether the early introduction of allergenic foods in the diet of breast-fed infants would protect against the development of food allergy...