eosinophilic esophagitis


Summary: Chronic ESOPHAGITIS characterized by esophageal mucosal EOSINOPHILIA. It is diagnosed when an increase in EOSINOPHILS are present over the entire esophagus. The reflux symptoms fail to respond to PROTON PUMP INHIBITORS treatment, unlike in GASTROESOPHAGEAL REFLUX DISEASE. The symptoms are associated with IgE-mediated hypersensitivity to food or inhalant allergens.

Top Publications

  1. Hruz P, Straumann A, Bussmann C, Heer P, Simon H, Zwahlen M, et al. Escalating incidence of eosinophilic esophagitis: a 20-year prospective, population-based study in Olten County, Switzerland. J Allergy Clin Immunol. 2011;128:1349-1350.e5 pubmed publisher
  2. Alexander J. Editorial: Deep Remission in Eosinophilic Esophagitis With Long-Term Steroids: Difficult to Attain and Maintain. Am J Gastroenterol. 2017;112:1536-1537 pubmed publisher
    The study by Greuter et al. entitled "Long-term treatment of eosinophilic esophagitis and swallowed topical corticosteroids: development and evaluation of a therapeutic concept" follows 351 patients over 6 years...
  3. Pesek R, Rettiganti M, O Brien E, Beckwith S, Daniel C, Luo C, et al. Effects of allergen sensitization on response to therapy in children with eosinophilic esophagitis. Ann Allergy Asthma Immunol. 2017;119:177-183 pubmed publisher
    In children with eosinophilic esophagitis (EoE) foods are the most common disease triggers, but environmental allergens are also suspected culprits...
  4. Bartuzi Z, Cocco R, Muraro A, Nowak Wegrzyn A. Contribution of Molecular Allergen Analysis in Diagnosis of Milk Allergy. Curr Allergy Asthma Rep. 2017;17:46 pubmed publisher
    ..Specific IgE-binding patterns to casein and beta-lactoglobulin peptides may also predict response to milk OITand identify patientsmost likely to benefit fromOIT. ..
  5. Dellon E. Management of refractory eosinophilic oesophagitis. Nat Rev Gastroenterol Hepatol. 2017;14:479-490 pubmed publisher
  6. Menard Katcher C, Benitez A, Pan Z, Ahmed F, Wilkins B, Capocelli K, et al. Influence of Age and Eosinophilic Esophagitis on Esophageal Distensibility in a Pediatric Cohort. Am J Gastroenterol. 2017;112:1466-1473 pubmed publisher
    Sequelae of eosinophilic esophagitis (EoE) include food impaction and esophageal stricture. Duration of inflammation is a predicted risk factor; however, complications remain unpredictable...
  7. Hirano I. Therapeutic end points in eosinophilic esophagitis: is elimination of esophageal eosinophils enough?. Clin Gastroenterol Hepatol. 2012;10:750-2 pubmed publisher
  8. Carlson D. Editorial: Widening the Use of the Functional Lumen Imaging Probe to Kids With Eosinophilic Esophagitis: Esophageal Narrowing is not Just an Adult Problem. Am J Gastroenterol. 2017;112:1474-1476 pubmed publisher
    ..measurement of esophageal distensibility, thus offering a unique and potentially valuable assessment in eosinophilic esophagitis (EoE)...
  9. Katzka D, Smyrk T, Alexander J, Geno D, Beitia R, Chang A, et al. Accuracy and Safety of the Cytosponge for Assessing Histologic Activity in Eosinophilic Esophagitis: A Two-Center Study. Am J Gastroenterol. 2017;112:1538-1544 pubmed publisher
    Management of eosinophilic esophagitis (EoE) requires repeated endoscopic mucosal sampling to assess disease activity. A less invasive and expensive means of monitoring of EoE is required...

More Information


  1. Lucendo A, Arias A, González Cervera J, Olalla J, Molina Infante J. Dual response to dietary/topical steroid and proton pump inhibitor therapy in adult patients with eosinophilic esophagitis. J Allergy Clin Immunol. 2016;137:931-4.e2 pubmed publisher
  2. Ishimura N, Ishihara S, Kinoshita Y. Sustained Acid Suppression by Potassium-Competitive Acid Blocker (P-CAB) May Be An Attractive Treatment Candidate for Patients with Eosinophilic Esophagitis. Am J Gastroenterol. 2016;111:1203-4 pubmed publisher
  3. Moole H, Jacob K, Duvvuri A, Moole V, Dharmapuri S, Boddireddy R, et al. Role of endoscopic esophageal dilation in managing eosinophilic esophagitis: A systematic review and meta-analysis. Medicine (Baltimore). 2017;96:e5877 pubmed publisher
    b>Eosinophilic esophagitis (EoE) is a chronic, immune-mediated disorder of the esophagus characterized by mucosal eosinophilic infiltration...
  4. Warners M, van Rhijn B, Verheij J, Smout A, Bredenoord A. Disease activity in eosinophilic esophagitis is associated with impaired esophageal barrier integrity. Am J Physiol Gastrointest Liver Physiol. 2017;313:G230-G238 pubmed publisher
    In eosinophilic esophagitis (EoE), the esophageal barrier integrity is impaired. Integrity can be assessed with different techniques...
  5. Sharaf R, Shergill A, Odze R, Krinsky M, Fukami N, Jain R, et al. Endoscopic mucosal tissue sampling. Gastrointest Endosc. 2013;78:216-24 pubmed publisher
  6. Ray K. Oesophagus: TSLP-basophil axis important in eosinophilic oesophagitis. Nat Rev Gastroenterol Hepatol. 2013;10:502 pubmed publisher
  7. Gill R, Al Subu A, Elitsur Y, Gupta R, Treem W, Rabinowitz S, et al. Prevalence and characteristics of eosinophilic esophagitis in 2 ethnically distinct pediatric populations. J Allergy Clin Immunol. 2014;133:576-7 pubmed publisher
  8. Fahey L, Liacouras C. Eosinophilic Gastrointestinal Disorders. Pediatr Clin North Am. 2017;64:475-485 pubmed publisher
    b>Eosinophilic esophagitis (EoE) is an atopic disease that is characterized by an isolated infiltration of eosinophils into the epithelium of the esophagus and is triggered by specific allergens...
  9. Ridolo E, De Angelis G, Dall aglio P. Eosinophilic esophagitis after specific oral tolerance induction for egg protein. Ann Allergy Asthma Immunol. 2011;106:73-4 pubmed publisher
  10. Greuter T, Bussmann C, Safroneeva E, Schoepfer A, Biedermann L, Vavricka S, et al. Long-Term Treatment of Eosinophilic Esophagitis With Swallowed Topical Corticosteroids: Development and Evaluation of a Therapeutic Concept. Am J Gastroenterol. 2017;112:1527-1535 pubmed publisher
    ..STCs) are efficacious in inducing and presumably maintaining remission in patients with active eosinophilic esophagitis (EoE)...
  11. Gnanasekaran T, Gnanasekaran S, Wood J, Friedland P. Eosinophilic oesophagitis: an otolaryngologist's perspective. Br J Hosp Med (Lond). 2017;78:338-340 pubmed publisher
    ..It illustrates early signs of eosinophilic oesophagitis so that primary physicians and emergency physicians know when to refer on to otolaryngologists. ..
  12. Blanchard C, Simon D, Schoepfer A, Straumann A, Simon H. Eosinophilic esophagitis: unclear roles of IgE and eosinophils. J Intern Med. 2017;281:448-457 pubmed publisher
    b>Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the oesophagus...
  13. Furuta G, Katzka D. Eosinophilic Esophagitis. N Engl J Med. 2015;373:1640-8 pubmed publisher
  14. Davis B, Epstein T, Kottyan L, Amin P, Martin L, Maddox A, et al. Association of eosinophilic esophagitis and hypertrophic cardiomyopathy. J Allergy Clin Immunol. 2016;137:934-6.e5 pubmed publisher
  15. Philla K, Min S, Hefner J, Howard R, Reinhardt B, Nazareno L, et al. Swallowed glucocorticoid therapy for eosinophilic esophagitis in children does not suppress adrenal function. J Pediatr Endocrinol Metab. 2015;28:1101-6 pubmed publisher
    ..to examine the effect of chronic swallowed glucocorticoids on adrenal function during the treatment of eosinophilic esophagitis (EoE) in children...
  16. Lomazi E, Brandalise N, Servidoni M, Cardoso S, Meirelles L. MAST CELLS DISTINGUISH EOSINOPHILIC ESOPHAGITIS IN PEDIATRIC PATIENTS. Arq Gastroenterol. 2017;54:192-196 pubmed publisher
    ..To evaluate whether mast cell count in the esophageal epithelium can discriminate eosinophilic esophagitis, proton-pump inhibitor (PPI)-responsive eosinophilic esophagitis and gastroesophageal reflux esophagitis...
  17. Warners M, Vlieg Boerstra B, Verheij J, van Hamersveld P, van Rhijn B, van Ampting M, et al. Esophageal and Small Intestinal Mucosal Integrity in Eosinophilic Esophagitis and Response to an Elemental Diet. Am J Gastroenterol. 2017;112:1061-1071 pubmed publisher
    The esophageal mucosal integrity is impaired in eosinophilic esophagitis (EoE) and it has been suggested that the duodenal permeability is increased. The absence of food allergens may restore the integrity...
  18. Sánchez Garcia S, Rodríguez Del Río P, Escudero C, Martínez Gómez M, Ibañez M. Possible eosinophilic esophagitis induced by milk oral immunotherapy. J Allergy Clin Immunol. 2012;129:1155-7 pubmed publisher
  19. Sodikoff J, Hirano I. Proton pump inhibitor-responsive esophageal eosinophilia does not preclude food-responsive eosinophilic esophagitis. J Allergy Clin Immunol. 2016;137:631-3 pubmed publisher
  20. Gomez Torrijos E, Garcia Rodriguez C, Rodriguez J, De la Roca F, Cardenas R, Alfaya F, et al. Occupational asthma and eosinophilic esophagitis in a patient with egg-bird syndrome. J Investig Allergol Clin Immunol. 2015;25:61-2 pubmed
  21. Garcia Rojo M, Sanchez J, De La Santa E, Durán E, Ruiz J, Silva A, et al. Automated image analysis in the study of lymphocyte subpopulation in eosinophilic oesophagitis. Diagn Pathol. 2014;9 Suppl 1:S7 pubmed publisher
    ..Positive pixel count algorithm can be a useful tool to quantify the immunohistochemical expression of inflammatory cells in the diagnosis and follow up of eosinophilic oesophagitis. ..
  22. Pera J, Palma D, Donovan T. Eosinophilic Esophagitis in a Kitten. J Am Anim Hosp Assoc. 2017;53:214-220 pubmed publisher
    ..8 eosinophils per high power field, supportive of eosinophilic esophagitis (EoE). Significant clinical improvement was seen with dietary modification using a hydrolyzed diet...
  23. Katzka D. Eosinophilic Esophagitis: Leaky Gullet or Leaky Gut?. Am J Gastroenterol. 2017;112:1072-1073 pubmed publisher
    b>Eosinophilic esophagitis (EoE) is a food allergen disorder driven by antigen recognition in the gastrointestinal tract. The study by Warners et al...