hypersensitivity

Summary

Summary: Altered reactivity to an antigen, which can result in pathologic reactions upon subsequent exposure to that particular antigen.

Top Publications

  1. Wightman P, Jackson G, Dipple K. Glycerol hypersensitivity in a Drosophila model for glycerol kinase deficiency is affected by mutations in eye pigmentation genes. PLoS ONE. 2012;7:e31779 pubmed publisher
    ..Due to the hygroscopic nature of glycerol, we predict glycerol hypersensitivity is a result of greater susceptibility to desiccation, suggesting glycerol kinase to play an important role in ..
  2. Viney J, Andrew D, Phillips R, Meiser A, Patel P, Lennartz Walker M, et al. Distinct conformations of the chemokine receptor CCR4 with implications for its targeting in allergy. J Immunol. 2014;192:3419-27 pubmed publisher
    ..This finding suggests that the selective blockade of CCR4 in allergy may be feasible when one CCR4 ligand dominates, allowing the inhibition of Th2 signaling via one ligand while sparing regulatory T cell recruitment via another. ..
  3. Zhou L, Huang J, Gao J, Zhang G, Jiang J. NMDA and AMPA receptors in the anterior cingulate cortex mediates visceral pain in visceral hypersensitivity rats. Cell Immunol. 2014;287:86-90 pubmed publisher
    ..cingulate cortex (ACC) neurons plays critical roles in modulating visceral pain responses in visceral hypersensitivity (VH) rats...
  4. Trompette A, Gollwitzer E, Yadava K, Sichelstiel A, Sprenger N, Ngom Bru C, et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med. 2014;20:159-66 pubmed publisher
    ..Our results show that dietary fermentable fiber and SCFAs can shape the immunological environment in the lung and influence the severity of allergic inflammation. ..
  5. Schurink A, Wolc A, Ducro B, Frankena K, Garrick D, Dekkers J, et al. Genome-wide association study of insect bite hypersensitivity in two horse populations in the Netherlands. Genet Sel Evol. 2012;44:31 pubmed publisher
    Insect bite hypersensitivity is a common allergic disease in horse populations worldwide. Insect bite hypersensitivity is affected by both environmental and genetic factors...
  6. Wang Y, Dai S. Structural basis of metal hypersensitivity. Immunol Res. 2013;55:83-90 pubmed publisher
    Metal hypersensitivity is a common immune disorder. Human immune systems mount the allergic attacks on metal ions through skin contacts, lung inhalation and metal-containing artificial body implants...
  7. Hamza E, Akdis C, Wagner B, Steinbach F, Marti E. In vitro induction of functional allergen-specific CD4+ CD25high Treg cells in horses affected with insect bite hypersensitivity. Clin Exp Allergy. 2013;43:889-901 pubmed publisher
    Insect bite hypersensitivity (IBH) is a recurrent allergic dermatitis of horses with similarities to human atopic eczema, caused by bites of insects of the genus Culicoides...
  8. Senti G, Crameri R, Kuster D, Johansen P, Martínez Gómez J, Graf N, et al. Intralymphatic immunotherapy for cat allergy induces tolerance after only 3 injections. J Allergy Clin Immunol. 2012;129:1290-6 pubmed publisher
    ..Subcutaneous allergen-specific immunotherapy frequently causes allergic side effects and requires 30 to 80 injections over 3 to 5 years...
  9. von Mutius E. Maternal farm exposure/ingestion of unpasteurized cow's milk and allergic disease. Curr Opin Gastroenterol. 2012;28:570-6 pubmed publisher
    ..One example is the low prevalence of childhood asthma and allergies amongst children raised on farms, particularly those exposed to farm animals and unprocessed cow's milk very early in life which are being reviewed in this article...

More Information

Publications62

  1. Tedner S, Ortqvist A, Almqvist C. Fetal growth and risk of childhood asthma and allergic disease. Clin Exp Allergy. 2012;42:1430-47 pubmed publisher
  2. Bisgaard H, Vissing N, Carson C, Bischoff A, Følsgaard N, Kreiner Møller E, et al. Deep phenotyping of the unselected COPSAC2010 birth cohort study. Clin Exp Allergy. 2013;43:1384-94 pubmed publisher
  3. Granchi D, Cenni E, Giunti A, Baldini N. Metal hypersensitivity testing in patients undergoing joint replacement: a systematic review. J Bone Joint Surg Br. 2012;94:1126-34 pubmed publisher
    ..Our purpose was to assess the risk of developing metal hypersensitivity post-operatively and its relationship with outcome and to investigate the advantages of performing ..
  4. Pulendran B, Artis D. New paradigms in type 2 immunity. Science. 2012;337:431-5 pubmed publisher
  5. Burks A, Calderon M, Casale T, Cox L, Demoly P, Jutel M, et al. Update on allergy immunotherapy: American Academy of Allergy, Asthma & Immunology/European Academy of Allergy and Clinical Immunology/PRACTALL consensus report. J Allergy Clin Immunol. 2013;131:1288-96.e3 pubmed publisher
    ..This resulting report is endorsed by both academies...
  6. Zhang H, Hu J, Zhou Y, Hu S, Wang Y, Chen W, et al. Promoted interaction of nuclear factor-?B with demethylated cystathionine-?-synthetase gene contributes to gastric hypersensitivity in diabetic rats. J Neurosci. 2013;33:9028-38 pubmed publisher
    Patients with long-standing diabetes frequently demonstrate gastric hypersensitivity with an unknown mechanism...
  7. Prescott S. Early-life environmental determinants of allergic diseases and the wider pandemic of inflammatory noncommunicable diseases. J Allergy Clin Immunol. 2013;131:23-30 pubmed publisher
    ..In this context allergic disease provides a very important early target to assess the effectiveness of environmental strategies to reduce immune dysregulation...
  8. Michaud D, Langevin S, Eliot M, Nelson H, McClean M, Christensen B, et al. Allergies and risk of head and neck cancer. Cancer Causes Control. 2012;23:1317-22 pubmed publisher
    ..Additional research into related mechanisms may provide new insights into how to treat HNSCC. These findings may provide new insight into biological pathways that could lead to a better understanding of the etiology of this disease. ..
  9. Kallen B, Finnström O, Nygren K, Otterblad Olausson P. Maternal drug use during pregnancy and asthma risk among children. Pediatr Allergy Immunol. 2013;24:28-32 pubmed publisher
    ..We wanted to analyze these associations with consideration to the confounding of maternal asthma...
  10. Islam S, Luster A. T cell homing to epithelial barriers in allergic disease. Nat Med. 2012;18:705-15 pubmed publisher
    ..Inflammation- and tissue-specific T lymphocyte trafficking pathways are currently being targeted as new treatments for non-allergic inflammatory diseases and may yield effective new therapeutics for allergic diseases...
  11. Kumagai G, Tsoulfas P, Toh S, McNiece I, Bramlett H, Dietrich W. Genetically modified mesenchymal stem cells (MSCs) promote axonal regeneration and prevent hypersensitivity after spinal cord injury. Exp Neurol. 2013;248:369-80 pubmed publisher
    ..and MSC-MNTS1/p75(-), but not the naïve MSCs, enhanced axonal growth and significantly prevented cutaneous hypersensitivity after SCI...
  12. Hilger C, Kuehn A, Hentges F. Animal lipocalin allergens. Curr Allergy Asthma Rep. 2012;12:438-47 pubmed publisher
    ..The use of single, well characterized allergens for diagnosis will allow the identification of the sensitizing animal, which is a prerequisite for specific immunotherapy...
  13. Wang D, Curtis A, Papp A, Koletar S, Para M. Polymorphism in glutamate cysteine ligase catalytic subunit (GCLC) is associated with sulfamethoxazole-induced hypersensitivity in HIV/AIDS patients. BMC Med Genomics. 2012;5:32 pubmed publisher
    ..SMX-induced hypersensitivity is an idiosyncratic cutaneous drug reaction with genetic components...
  14. Kiyatkin M, Feng B, Schwartz E, Gebhart G. Combined genetic and pharmacological inhibition of TRPV1 and P2X3 attenuates colorectal hypersensitivity and afferent sensitization. Am J Physiol Gastrointest Liver Physiol. 2013;305:G638-48 pubmed publisher
    ..P2X3 have been reported to facilitate colorectal afferent neuron sensitization, thus contributing to organ hypersensitivity and pain...
  15. Barber D, Arias J, Boquete M, Cardona V, Carrillo T, Gala G, et al. Analysis of mite allergic patients in a diverse territory by improved diagnostic tools. Clin Exp Allergy. 2012;42:1129-38 pubmed publisher
    ..There are few studies comparing the sensitization with mite allergens from different mite species which could potentially be the cause of allergy...
  16. He S, Zhang H, Zeng X, Yang P. Self-amplification mechanisms of mast cell activation: a new look in allergy. Curr Mol Med. 2012;12:1329-39 pubmed
  17. Sicherer S, Leung D. Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2012. J Allergy Clin Immunol. 2013;131:55-66 pubmed publisher
    This review highlights some of the research advances in anaphylaxis; hypersensitivity reactions to foods, drugs, and insects; and allergic skin diseases that were reported in the Journal in 2012...
  18. Kim S, Jo E, Kim M, Lee S, Kim M, Yang M, et al. Clinical value of radiocontrast media skin tests as a prescreening and diagnostic tool in hypersensitivity reactions. Ann Allergy Asthma Immunol. 2013;110:258-62 pubmed publisher
    Some radiocontrast media (RCM) hypersensitivity reactions may have underlying IgE- or T-cell-mediated mechanisms. RCM skin testing may be useful for predicting future reactions.
  19. Gangadharan V, Kuner R. Pain hypersensitivity mechanisms at a glance. Dis Model Mech. 2013;6:889-95 pubmed publisher
    ..article endeavors to provide an overview of how molecular and cellular mechanisms underlying nociception in a physiological context undergo plasticity in pathophysiological states, leading to pain hypersensitivity and chronic pain.
  20. Fu Y, Lou H, Wang C, Lou W, Wang Y, Zheng T, et al. T cell subsets in cord blood are influenced by maternal allergy and associated with atopic dermatitis. Pediatr Allergy Immunol. 2013;24:178-86 pubmed publisher
    ..This study aimed to investigate the influence of maternal allergy on cord blood regulatory and effector T cells and to evaluate their role as a predictor of atopic dermatitis (AD) during the first 2 yr of life...
  21. Jeffery I, Quigley E, Ohman L, Simren M, O Toole P. The microbiota link to irritable bowel syndrome: an emerging story. Gut Microbes. 2012;3:572-6 pubmed publisher
    ..This addendum contextualizes and summarizes the results of these studies, and defines the future challenges and opportunities in the field...
  22. Kim M, Park C, Kim D, Kim K, Kim H, Lim K, et al. Surveillance of contrast-media-induced hypersensitivity reactions using signals from an electronic medical recording system. Ann Allergy Asthma Immunol. 2012;108:167-71 pubmed publisher
    Contrast-media (CM) hypersensitivity is a well-known adverse drug reaction. Surveillance of adverse drug reactions usually depends on spontaneous reports. However, the rate of spontaneous reports is low...
  23. Chang J, Tsai Y, Tsai C, Wiemels J. Allergy and risk of childhood acute lymphoblastic leukemia: a population-based and record-based study. Am J Epidemiol. 2012;176:970-8 pubmed publisher
    ..3, 95% CI: 1.1, 1.5), and before the age of 1 year (OR = 1.4, 95% CI: 1.1, 1.7). These results suggest that the pathogenesis of childhood ALL and allergy share a common biologic mechanism...
  24. D Vaz N, Ma Y, Dunstan J, Lee Pullen T, Hii C, Meldrum S, et al. Neonatal protein kinase C zeta expression determines the neonatal T-Cell cytokine phenotype and predicts the development and severity of infant allergic disease. Allergy. 2012;67:1511-8 pubmed publisher
    ..This study examined whether this relationship extends to a general population and addressed the basis for the association...
  25. Lødrup Carlsen K, Roll S, Carlsen K, Mowinckel P, Wijga A, Brunekreef B, et al. Does pet ownership in infancy lead to asthma or allergy at school age? Pooled analysis of individual participant data from 11 European birth cohorts. PLoS ONE. 2012;7:e43214 pubmed publisher
    ..To examine the associations between pet keeping in early childhood and asthma and allergies in children aged 6-10 years...
  26. Morales E, Garcia Esteban R, Guxens M, Guerra S, Mendez M, Molto Puigmarti C, et al. Effects of prolonged breastfeeding and colostrum fatty acids on allergic manifestations and infections in infancy. Clin Exp Allergy. 2012;42:918-28 pubmed publisher
    ..In developed countries World Health Organization recommendation of 6 months' exclusive breastfeeding is under debate...
  27. Valenta R, Campana R, Marth K, van Hage M. Allergen-specific immunotherapy: from therapeutic vaccines to prophylactic approaches. J Intern Med. 2012;272:144-57 pubmed publisher
    ..Finally, we discuss possible allergen-specific strategies for prevention of allergic disease...
  28. Hanski I, von Hertzen L, Fyhrquist N, Koskinen K, Torppa K, Laatikainen T, et al. Environmental biodiversity, human microbiota, and allergy are interrelated. Proc Natl Acad Sci U S A. 2012;109:8334-9 pubmed publisher
    ..These results raise fundamental questions about the consequences of biodiversity loss for both allergic conditions and public health in general...
  29. Chen H, Xie W, Hu F, Zhang Y, Wang J, Wang Y. Disruption of ?-opioid receptor phosphorylation at threonine 161 attenuates morphine tolerance in rats with CFA-induced inflammatory hypersensitivity. Neurosci Bull. 2012;28:182-92 pubmed publisher
    ..The aim of this study was to assess the function of DOR phosphorylation by Cdk5 in complete Freund's adjuvant (CFA)-induced inflammatory pain and morphine tolerance...
  30. Bae Y, Moon K, Kim T, Jang Y, Lee Y, Park C, et al. The role of nitrosative stress in the pathogenesis of unexplained chronic cough with cough hypersensitivity. Am J Rhinol Allergy. 2012;26:e10-4 pubmed publisher
    ..We hypothesized that nitrosative stress in the upper airway might play a role in cough hypersensitivity by causing neurochemical abnormalities.
  31. Khandelwal P, Blanco Mezquita T, Emami P, Lee H, Reyes N, Mathew R, et al. Ocular mucosal CD11b+ and CD103+ mouse dendritic cells under normal conditions and in allergic immune responses. PLoS ONE. 2013;8:e64193 pubmed publisher
    ..Thus, although CD11b+ and CD103+ DC are both present in the normal ocular mucosa, the CD11b+ DC subset plays a dominant role in a mouse model of ocular allergy...
  32. Paveglio S, Puddington L, Rafti E, Matson A. FcRn-mediated intestinal absorption of IgG anti-IgE/IgE immune complexes in mice. Clin Exp Allergy. 2012;42:1791-800 pubmed publisher
    ..The mechanism(s) responsible for the acquisition of maternal antibody isotypes other than IgG are not fully understood...
  33. Qian A, Song D, Li Y, Liu X, Tang D, Yao W, et al. Role of voltage gated Ca2+ channels in rat visceral hypersensitivity change induced by 2,4,6-trinitrobenzene sulfonic acid. Mol Pain. 2013;9:15 pubmed publisher
    ..We investigated the molecular mechanisms and the role for voltage gated calcium channel (VGCC) in the pathogenesis in a rat model of 2,4,6-trinitrobenzenesulfonic acid (TNBS) induced visceral inflammatory hypersensitivity.
  34. Crouzet L, Gaultier E, Del homme C, Cartier C, Delmas E, Dapoigny M, et al. The hypersensitivity to colonic distension of IBS patients can be transferred to rats through their fecal microbiota. Neurogastroenterol Motil. 2013;25:e272-82 pubmed publisher
    Alterations of intestinal microbiota and hypersensitivity to colonic distension are two features of the irritable bowel syndrome (IBS)...
  35. Wang H, Cheng G, Du Y, Ye L, Chen W, Zhang L, et al. Hypersensitivity reaction studies of a polyethoxylated castor oil-free, liposome-based alternative paclitaxel formulation. Mol Med Rep. 2013;7:947-52 pubmed publisher
    The commercial drug paclitaxel (Taxol) may introduce hypersensitivity reactions associated with the polyethoxylated castor oil-ethanol solvent...
  36. Hatch R, Jennings E, Ivanusic J. Peripheral hyperpolarization-activated cyclic nucleotide-gated channels contribute to inflammation-induced hypersensitivity of the rat temporomandibular joint. Eur J Pain. 2013;17:972-82 pubmed publisher
    ..In the current study, we investigated HCN channel involvement in inflammatory pain of the temporomandibular joint (TMJ)...
  37. Murota H, Izumi M, Abd El Latif M, Nishioka M, Terao M, Tani M, et al. Artemin causes hypersensitivity to warm sensation, mimicking warmth-provoked pruritus in atopic dermatitis. J Allergy Clin Immunol. 2012;130:671-682.e4 pubmed publisher
    ..Itch impairs the quality of life for many patients with dermatoses, especially atopic dermatitis (AD), and is frequently induced by a warm environment...
  38. Erkkola M, Nwaru B, Kaila M, Kronberg Kippilä C, Ilonen J, Simell O, et al. Risk of asthma and allergic outcomes in the offspring in relation to maternal food consumption during pregnancy: a Finnish birth cohort study. Pediatr Allergy Immunol. 2012;23:186-94 pubmed publisher
  39. Flicker S, Linhart B, Wild C, Wiedermann U, Valenta R. Passive immunization with allergen-specific IgG antibodies for treatment and prevention of allergy. Immunobiology. 2013;218:884-91 pubmed publisher
  40. Chen K, Blatt K, Thomas W, Swoboda I, Valent P, Valenta R, et al. Hypoallergenic Der p 1/Der p 2 combination vaccines for immunotherapy of house dust mite allergy. J Allergy Clin Immunol. 2012;130:435-43.e4 pubmed publisher
    ..More than 50% of allergic patients have house dust mite (HDM) allergy. Group 1 and 2 allergens are the major HDM allergens...
  41. Forsberg B, Bråbäck L, Keune H, Kobernus M, Krayer von Krauss M, Yang A, et al. An expert assessment on climate change and health - with a European focus on lungs and allergies. Environ Health. 2012;11 Suppl 1:S4 pubmed publisher
    ..Additionally exposure to moulds and contaminants from water damaged buildings may increase...
  42. Abdelmoaty S, Wigerblad G, Bas D, Codeluppi S, Fernández Zafra T, El Awady E, et al. Spinal actions of lipoxin A4 and 17(R)-resolvin D1 attenuate inflammation-induced mechanical hypersensitivity and spinal TNF release. PLoS ONE. 2013;8:e75543 pubmed publisher
    ..assess if spinal administration of lipoxin A4 (LXA4) or 17 (R)-resolvin D1 (17(R)-RvD1) attenuates mechanical hypersensitivity in the carrageenan model of peripheral inflammation in the rat...
  43. Barabas M, Stucky C. TRPV1, but not TRPA1, in primary sensory neurons contributes to cutaneous incision-mediated hypersensitivity. Mol Pain. 2013;9:9 pubmed publisher
    ..In rodents, skin-only incisions induce mechanical and heat hypersensitivity similar to levels observed with skin plus deep incisions...
  44. Maes T, Joos G, Brusselle G. Targeting interleukin-4 in asthma: lost in translation?. Am J Respir Cell Mol Biol. 2012;47:261-70 pubmed publisher
    ..In this review, we will address the role of IL-4 in asthma, describe IL-4 signaling, and give an overview of preclinical and clinical studies targeting the IL-4 Receptor pathway...
  45. Smallwood J, Ownby D. Exposure to dog allergens and subsequent allergic sensitization: an updated review. Curr Allergy Asthma Rep. 2012;12:424-8 pubmed publisher
    ..A better understanding of the variables influencing the outcome of in-home dog exposure will hopefully make significant advances toward alleviating the symptoms associated with allergic sensitization to dogs...
  46. Nilsson O, Binnmyr J, Zoltowska A, Saarne T, van Hage M, Grönlund H. Characterization of the dog lipocalin allergen Can f 6: the role in cross-reactivity with cat and horse. Allergy. 2012;67:751-7 pubmed publisher
    ..Three of four patients are allergic to more than one pet, which can only partially be explained by cross-reactivity between serum albumins. The lipocalin protein family harbours allergens in mammalian species...
  47. Shankar T, Petrov A. Omalizumab and hypersensitivity reactions. Curr Opin Allergy Clin Immunol. 2013;13:19-24 pubmed publisher
    ..reviewed the published studies and case reports of off-label omalizumab use in the prevention of IgE-mediated hypersensitivity reactions of various causes. Additionally, we have reviewed anaphylaxis associated with omalizumab treatment.
  48. Fernández Duro B, Cuervo Pineda N, Rodríguez Alvízar J, Celio Murillo R, Juárez Anaya D, Pérez Ortiz T. [Identification of house dust mite fauna from allergic patients' mattress in six Mexican states]. Rev Alerg Mex. 2013;60:87-92 pubmed
    ..House dust is considered an important source of aeroallergens, and the mites living there, are the main cause of allergy to it. In México, there have been few about house dust fauna, and mostly limited to México City...
  49. Ezell J, Wegienka G, Havstad S, Ownby D, Johnson C, Zoratti E. A cross-sectional analysis of pet-specific immunoglobulin E sensitization and allergic symptomatology and household pet keeping in a birth cohort population. Allergy Asthma Proc. 2013;34:504-10 pubmed publisher
    ..049). When cat-sensitized mothers report allergic symptoms to cats, these pets may be less likely to be kept in homes. Elevated dog and cat allergen sIgE does not appear to be associated with the keeping of these pets. ..
  50. Dębińska A, Boznanski A. [The role of Toll-like receptors in the pathogenesis of allergic diseases - where is the truth?]. Postepy Hig Med Dosw (Online). 2014;68:230-7 pubmed
    ..We will further discuss how we can reconcile inconsistencies in the results of existing studies and review information on the potential use of ligands for TLRs in allergy prevention and therapy. ..
  51. Sutovska M, Kocmálová M, Franova S, Vakkalanka S, Viswanadha S. Pharmacodynamic evaluation of RP3128, a novel and potent CRAC channel inhibitor in guinea pig models of allergic asthma. Eur J Pharmacol. 2016;772:62-70 pubmed publisher
    ..Data demonstrate the therapeutic potential of RP3128 in respiratory diseases causally associated with allergic inflammation. ..
  52. Curin M, Garib V, Valenta R. Single recombinant and purified major allergens and peptides: How they are made and how they change allergy diagnosis and treatment. Ann Allergy Asthma Immunol. 2017;119:201-209 pubmed publisher
    ..Despite many challenges, such as high cost of clinical trials and regulative issues, allergy vaccines based on recombinant allergens and peptides are being developed and will likely soon be available on the market. ..
  53. Lluis A, Ballenberger N, Illi S, Schieck M, Kabesch M, Illig T, et al. Regulation of TH17 markers early in life through maternal farm exposure. J Allergy Clin Immunol. 2014;133:864-71 pubmed publisher
    ..However, the underlying mechanisms might involve immune modulation of additional T-cell populations, such as TH17 cells, influenced by genetic predisposition...