membranous glomerulonephritis

Summary

Summary: A type of glomerulonephritis that is characterized by the accumulation of immune deposits (COMPLEMENT MEMBRANE ATTACK COMPLEX) on the outer aspect of the GLOMERULAR BASEMENT MEMBRANE. It progresses from subepithelial dense deposits, to basement membrane reaction and eventual thickening of the basement membrane.

Top Publications

  1. Ronco P, Debiec H. Molecular dissection of target antigens and nephritogenic antibodies in membranous nephropathy: towards epitope-driven therapies. J Am Soc Nephrol. 2006;17:1772-4 pubmed
  2. Troxell M, Saxena A, Kambham N. Concurrent anti-glomerular basement membrane disease and membranous glomerulonephritis: a case report and literature review. Clin Nephrol. 2006;66:120-7 pubmed
    ..The sequential or simultaneous presentation of anti-glomerular basement membrane disease with membranous glomerulonephritis has been infrequently described.
  3. Ponticelli C. Membranous nephropathy. J Nephrol. 2007;20:268-87 pubmed
  4. El Kossi M, Harmer A, Goodwin J, Wagner B, Shortland J, Angel C, et al. De novo membranous nephropathy associated with donor-specific alloantibody. Clin Transplant. 2008;22:124-7 pubmed publisher
    ..Cases of DNMG should be screened for alloantibody and the presence of alloantibody may influence the choice of therapy...
  5. Lo W, Chen S, Wang H, Shih H, Chen C, Tsai C, et al. Association between genetic polymorphisms of the NPHS1 gene and membranous glomerulonephritis in the Taiwanese population. Clin Chim Acta. 2010;411:714-8 pubmed publisher
    b>Membranous glomerulonephritis (MGN) is one of the most common causes of nephrotic syndrome in adults. NPHS1 encoding nephrin is a transmembrane protein of the immunoglobulin family...
  6. do Nascimento A, Viana V, Testagrossa L, Leon E, Borba E, Barros R, et al. Antibodies to ribosomal P proteins: a potential serologic marker for lupus membranous glomerulonephritis. Arthritis Rheum. 2006;54:1568-72 pubmed
    ..To evaluate the relevance of antibodies to ribosomal P proteins (anti-P antibodies) in discriminating histopathologic patterns of lupus nephritis...
  7. Chen A, Frank R, Vento S, Crosby V, Chandra M, Gauthier B, et al. Idiopathic membranous nephropathy in pediatric patients: presentation, response to therapy, and long-term outcome. BMC Nephrol. 2007;8:11 pubmed
    ..We conducted this study to evaluate pediatric patients with IMN in order to clarify the presentation, response to therapy, and clinical outcome...
  8. Jiménez A, Sanchez B, Pérez Alenza D, Garcia P, López J, Rodriguez A, et al. Membranous glomerulonephritis in the Iberian lynx (Lynx pardinus). Vet Immunol Immunopathol. 2008;121:34-43 pubmed
    ..A focal, diffuse membranous glomerulonephritis (MGN) that progressed with age was diagnosed in all but one of the animals in different stages not ..
  9. Ahmed M, Wong C. Rituximab and nephrotic syndrome: a new therapeutic hope?. Nephrol Dial Transplant. 2008;23:11-7 pubmed

More Information

Publications62

  1. Valentini R, Mattoo T, Kapur G, Imam A. Membranous glomerulonephritis: treatment response and outcome in children. Pediatr Nephrol. 2009;24:301-8 pubmed publisher
    ..aim of this study was to characterize clinical features, treatment response, and outcome of idiopathic membranous glomerulonephritis (MGN) in a single-center cohort of children...
  2. Shah P, Tramontano A, Makker S. Intramolecular epitope spreading in Heymann nephritis. J Am Soc Nephrol. 2007;18:3060-6 pubmed
    ..with megalin induces active Heymann nephritis, which reproduces features of human idiopathic membranous glomerulonephritis. Megalin is a complex immunological target with four discrete ligand-binding domains (LBDs) that may ..
  3. Cohen C, Calvaresi N, Armelloni S, Schmid H, Henger A, Ott U, et al. CD20-positive infiltrates in human membranous glomerulonephritis. J Nephrol. 2005;18:328-33 pubmed
    b>Membranous glomerulonephritis (MGN), histologically defined by subepithelial immune deposits, is the most common cause of nephrotic syndrome in Caucasian adults...
  4. Shimizu S, Sugiyama N, Masutani K, Sadanaga A, Miyazaki Y, Inoue Y, et al. Membranous glomerulonephritis development with Th2-type immune deviations in MRL/lpr mice deficient for IL-27 receptor (WSX-1). J Immunol. 2005;175:7185-92 pubmed
    ..WSX-1-/- MRL/lpr mice developed disease resembling human membranous glomerulonephritis (World Health Organization class V) with a predominance of IgG1 in glomerular deposits, accompanied by ..
  5. Bantis C, Heering P, Aker S, Siekierka M, Kuhr N, Grabensee B, et al. Tumor necrosis factor-alpha gene G-308A polymorphism is a risk factor for the development of membranous glomerulonephritis. Am J Nephrol. 2006;26:12-5 pubmed
    ..We evaluated its influence on the incidence and clinical course of membranous glomerulonephritis.
  6. Choy B, Chan T, Lai K. Recurrent glomerulonephritis after kidney transplantation. Am J Transplant. 2006;6:2535-42 pubmed
    ..This review discusses commonly encountered recurrent glomerulonephritides, with special emphasis on the influence of post-transplant prophylactic immunosuppression and emerging treatments...
  7. Lee B, Cho H, Kang H, Ha I, Cheong H, Moon K, et al. Idiopathic membranous nephropathy in children. Pediatr Nephrol. 2006;21:1707-15 pubmed
    ..Presentation with NS (P=0.045) and the development of RVT (P=0.010) were identified as poor prognostic factors...
  8. Fervenza F, Sethi S, Specks U. Idiopathic membranous nephropathy: diagnosis and treatment. Clin J Am Soc Nephrol. 2008;3:905-19 pubmed publisher
  9. Nasr S, Said S, Valeri A, Stokes M, Masani N, D Agati V, et al. Membranous glomerulonephritis with ANCA-associated necrotizing and crescentic glomerulonephritis. Clin J Am Soc Nephrol. 2009;4:299-308 pubmed publisher
    Only rare cases of concurrent membranous glomerulonephritis (MGN) and antineutrophil cytoplasmic antibody (ANCA)-associated necrotizing and crescentic glomerulonephritis (NCGN) have been reported.
  10. Bomback A, Derebail V, McGregor J, Kshirsagar A, Falk R, Nachman P. Rituximab therapy for membranous nephropathy: a systematic review. Clin J Am Soc Nephrol. 2009;4:734-44 pubmed publisher
    ..The treatment of membranous nephropathy (MN) remains controversial. Rituximab, which selectively targets B cells, has emerged as a possible alternative treatment option with limited toxicity...
  11. Rastaldi M, Candiano G, Musante L, Bruschi M, Armelloni S, Rimoldi L, et al. Glomerular clusterin is associated with PKC-alpha/beta regulation and good outcome of membranous glomerulonephritis in humans. Kidney Int. 2006;70:477-85 pubmed
    Mechanisms for human membranous glomerulonephritis (MGN) remain elusive...
  12. Troyanov S, Roasio L, Pandes M, Herzenberg A, Cattran D. Renal pathology in idiopathic membranous nephropathy: a new perspective. Kidney Int. 2006;69:1641-8 pubmed
    ..However, the indicators of chronic injury are associated with age, blood pressure, and creatinine clearance at presentation and not with rate of disease progression or initial proteinuria...
  13. Obana M, Nakanishi K, Sako M, Yata N, Nozu K, Tanaka R, et al. Segmental membranous glomerulonephritis in children: comparison with global membranous glomerulonephritis. Clin J Am Soc Nephrol. 2006;1:723-9 pubmed
    Generally, idiopathic membranous glomerulonephritis (MGN) is a global glomerular disease that affects the whole of the glomerulus...
  14. Ronco P, Debiec H. Target antigens and nephritogenic antibodies in membranous nephropathy: of rats and men. Semin Immunopathol. 2007;29:445-58 pubmed
    ..In conclusion, substantial progresses have been made in understanding molecular mechanisms of membranous nephropathy, which should lead to novel therapeutic approaches...
  15. Praga M, Barrio V, Juárez G, Luno J. Tacrolimus monotherapy in membranous nephropathy: a randomized controlled trial. Kidney Int. 2007;71:924-30 pubmed
    ..The majority of patients experienced remission with a significant reduction in the risk for deteriorating renal function...
  16. Lai K. Membranous nephropathy: when and how to treat. Kidney Int. 2007;71:841-3 pubmed
    ..Currently, combinations of steroids with alkylating agents are best studied. Newer forms of immunosuppressive treatment are currently under study...
  17. Segarra A, Praga M, Ramos N, Polanco N, Cargol I, Gutierrez Solis E, et al. Successful treatment of membranous glomerulonephritis with rituximab in calcineurin inhibitor-dependent patients. Clin J Am Soc Nephrol. 2009;4:1083-8 pubmed publisher
    ..However, 60% of patients become treatment dependent and are at risk of chronic nephrotoxicity. The aim of this study was to evaluate the efficacy of rituximab in patients with long-term dependence on CNIs...
  18. Chen W, Chen S, Chen C, Chen H, Lin Y, Ho T, et al. Lack of association between transient receptor potential cation channel 6 polymorphisms and primary membranous glomerulonephritis. Ren Fail. 2010;32:666-72 pubmed publisher
    b>Membranous glomerulonephritis (MGN) is one common cause of idiopathic nephrotic syndrome...
  19. Ronco P, Debiec H. Molecular pathomechanisms of membranous nephropathy: from Heymann nephritis to alloimmunization. J Am Soc Nephrol. 2005;16:1205-13 pubmed
    ..Other types of alloimmunization should be investigated in MN but also in other renal and nonrenal diseases, particularly those that affect the pediatric age...
  20. Kawasaki Y, Suzuki J, Onishi N, Takahashi A, Isome M, Suzuki H. IgA deficiency and membranous glomerulonephritis presenting as nephrotic syndrome. Pediatr Nephrol. 2005;20:662-4 pubmed
    ..is rare and no previous reports in childhood have been made of the association of IgA deficiency and membranous glomerulonephritis (MGN). We report a 5-year-old boy with selective IgA deficiency and MGN...
  21. Nangaku M, Shankland S, Couser W. Cellular response to injury in membranous nephropathy. J Am Soc Nephrol. 2005;16:1195-204 pubmed
    ..Improved understanding of the role of complement in the pathogenesis of MN and of the cellular response to C5b-9 attack creates several new opportunities for therapeutic intervention that may benefit patients with MN in the future...
  22. Ponticelli C, Passerini P, Salvadori M, Manno C, Viola B, Pasquali S, et al. A randomized pilot trial comparing methylprednisolone plus a cytotoxic agent versus synthetic adrenocorticotropic hormone in idiopathic membranous nephropathy. Am J Kidney Dis. 2006;47:233-40 pubmed
    ..We conducted a pilot trial to compare the effectiveness and safety of 2 different treatments in patients with membranous nephropathy and nephrotic syndrome...
  23. Bertolaccini M, Murru V, Alba P, Khamashta M. Lack of association of antibodies to ribosomal P proteins with lupus membranous glomerulonephritis: comment on the article by Do Nascimento et al. Arthritis Rheum. 2006;54:4025-6; author reply 4026-7 pubmed
  24. Couser W, Nangaku M. Cellular and molecular biology of membranous nephropathy. J Nephrol. 2006;19:699-705 pubmed
    ..Expanded understanding of the molecular pathophysiology of MN has important implications for monitoring disease activity, predicting disease course and designing new approaches to therapy for this common glomerular disease...
  25. Ronco P, Debiec H. New insights into the pathogenesis of membranous glomerulonephritis. Curr Opin Nephrol Hypertens. 2006;15:258-63 pubmed
    ..This review focuses on new pathophysiologic aspects of the disease, with special emphasis on the antigenic targets of pathogenic antibodies...
  26. Makker S, Tramontano A. Differential capacity of anti-RAP and anti-megalin antibodies to produce progressive passive Heymann nephritis - implications for the pathogenesis of idiopathic human membranous glomerulonephritis. J Pathol. 2006;210:282-7 pubmed
    ..These observations could provide clues to the nature of the unknown glomerular autoantigen of idiopathic membranous glomerulonephritis in humans.
  27. Hasegawa Y, Kaneoka H, Tanaka T, Ogahara S, Matsumae T, Noda R, et al. Suppression of experimental membranous glomerulonephritis in rats by an anti-MHC class II antibody. Nephron. 2001;88:233-40 pubmed
  28. Kotnik V, Premzl A, Skoberne M, Malovrh T, Kveder R, Kaplan Pavlovcic S, et al. Demonstration of apoptosis-associated cleavage products of DNA, complement activation products SC5b-9 and C3d/dg, and immune complexes CIC-C3d, CIC-IgA, and CIC-IgG in the urine of patients with membranous glomerulonephritis. Croat Med J. 2003;44:707-11 pubmed
    To investigate the involvement of complement activation and apoptosis in the pathogenesis of membranous glomerulonephritis by determining the concentrations of apoptosis-associated 180 bp nucleosomes and complement activation products ..
  29. Debiec H, Guigonis V, Mougenot B, Decobert F, Haymann J, Bensman A, et al. Antenatal membranous glomerulonephritis due to anti-neutral endopeptidase antibodies. N Engl J Med. 2002;346:2053-60 pubmed
  30. Remuzzi G, Chiurchiu C, Abbate M, Brusegan V, Bontempelli M, Ruggenenti P. Rituximab for idiopathic membranous nephropathy. Lancet. 2002;360:923-4 pubmed
    ..CD20 B lymphocytes fell below normal ranges up to study end. The short-term risk-benefit profile of rituximab seems more favourable to that of any other immunosuppressive drug used to treat idiopathic membranous nephropathy...
  31. Filler G, Feber J, Weiler G, Le Saux N. Another case of HBV associated membranous glomerulonephritis resolving on lamivudine. Arch Dis Child. 2003;88:460 pubmed
  32. Takeuchi Y, Yoshikawa M, Tsukamoto N, Shiroi A, Hoshida Y, Enomoto Y, et al. Cronkhite-Canada syndrome with colon cancer, portal thrombosis, high titer of antinuclear antibodies, and membranous glomerulonephritis. J Gastroenterol. 2003;38:791-5 pubmed
    ..The biopsied renal specimen showed membranous glomerulonephritis. This is a rare case of CCS associated with various complications such as colon cancer, portal vein ..
  33. Filler G, Young E, Geier P, Carpenter B, Drukker A, Feber J. Is there really an increase in non-minimal change nephrotic syndrome in children?. Am J Kidney Dis. 2003;42:1107-13 pubmed
    ..A true increase in FSGS possibly could alter the current practice of withholding renal biopsy in childhood nephrotic syndrome (NS) unless the patient fails to respond to a 28-day course of corticosteroid therapy...
  34. Rossi L, Cardarelli F, Vampa M, Buzio C, Olivetti G. Membranous glomerulonephritis after haematopoietic cell transplantation for multiple myeloma. Nephron. 2001;88:260-3 pubmed
    ..We report a case of a recipient who developed nephrotic syndrome and membranous glomerulonephritis 22 months after the graft and 6 months after cyclosporine withdrawal...
  35. Fujimoto S, Hara S, Sato Y, Yamada K, Hisanaga S, Eto T. Nephrotic syndrome caused by membranous nephropathy: response to a short course of cyclophosphamide alternating with prednisolone. Intern Med. 2004;43:30-4 pubmed
    ..We examined outcomes of a short course of cyclophosphamide alternating with prednisolone for MN patients with nephrotic syndrome...
  36. Debiec H, Nauta J, Coulet F, van der Burg M, Guigonis V, Schurmans T, et al. Role of truncating mutations in MME gene in fetomaternal alloimmunisation and antenatal glomerulopathies. Lancet. 2004;364:1252-9 pubmed
    b>Membranous glomerulonephritis is an immune-mediated disease...
  37. Fischer E, Mougenot B, Callard P, Ronco P, Rossert J. Abnormal expression of glomerular basement membrane laminins in membranous glomerulonephritis. Nephrol Dial Transplant. 2000;15:1956-64 pubmed
    ..Analysis of mice harbouring a null mutation in the gene encoding the beta 2 chain of laminin has suggested that the presence of abnormal laminin chains within the GBM can be responsible for proteinuria...
  38. Danilewicz M, Wagrowska Danilewicz M, Antoszczyk L. A quantitative study of the interstitial expression of alpha-smooth muscle actin (alpha-SMA) in idiopathic membranous glomerulonephritis and minimal change disease in adults. Pol J Pathol. 2000;51:37-43 pubmed
    Twelve adult patients with early stages of idiopathic membranous glomerulonephritis (MGN) and 10 with minimal change disease (MCD) for whom both light and electron microscopy as well as immunofluorescence microscopy and full clinical ..
  39. Hartland A, Giles P, Bridger J, Simmons W. A case of membranous glomerulonephritis presenting as pulmonary embolism and acute hyperlipidaemia. J Clin Pathol. 2002;55:538-40 pubmed
    ..Subsequent investigation revealed that the hyperlipidaemia was secondary to nephrotic syndrome of glomerulonephritis. The case illustrates the importance of investigating acute hyperlipidaemia for its underlying causes...
  40. Meydanli M, Erguvan R, Altinok M, Ataoglu O, Kafkasli A. Rare case of neuroendocrine small cell carcinoma of the endometrium with paraneoplastic membranous glomerulonephritis. Tumori. 2003;89:213-7 pubmed
    ..We report a case of neuroendocrine small cell carcinoma of the endometrium associated with membranous glomerulonephritis (MGN), which appeared to be a component of an unusual paraneoplastic syndrome...
  41. Debiec H, Guigonis V, Mougenot B, Haymann J, Bensman A, Deschenes G, et al. Antenatal membranous glomerulonephritis with vascular injury induced by anti-neutral endopeptidase antibodies: toward new concepts in the pathogenesis of glomerular diseases. J Am Soc Nephrol. 2003;14 Suppl 1:S27-32 pubmed
  42. Illies F, Wingen A, Bald M, Hoyer P. Autoimmune thyroiditis in association with membranous nephropathy. J Pediatr Endocrinol Metab. 2004;17:99-104 pubmed
    ..For similar cases, we want to encourage colleagues to consider this hypothesis and to examine blood and renal biopsy specimens for the presence of megalin and antibodies against it...
  43. Uchiyama Tanaka Y, Mori Y, Kishimoto N, Nose A, Kijima Y, Nagata T, et al. Membranous glomerulonephritis associated with hepatitis C virus infection: case report and literature review. Clin Nephrol. 2004;61:144-50 pubmed
    ..Serum HCV antibody (Ab) and cryoglobulin were positive. Renal biopsy specimens showed features of membranous glomerulonephritis. The likely cause was immune complex-mediated glomerulonephritis associated with HCV infection...
  44. Ng S, Tan P, Chuah K, Cheng C, Tan J. A case of juxtaglomerular cell tumor associated with membranous glomerulonephritis. Ann Diagn Pathol. 2003;7:314-20 pubmed
    The association of membranous glomerulonephritis with benign tumors is rarely described...
  45. Hirayama K, Ebihara I, Yamamoto S, Kai H, Muro K, Yamagata K, et al. Predominance of type-2 immune response in idiopathic membranous nephropathy. Cytoplasmic cytokine analysis. Nephron. 2002;91:255-61 pubmed
    ..In this study, we investigated the immunoresponse of helper T cells, i.e. Th predominance in patients with idiopathic membranous nephropathy...
  46. Grone H, Gröne E, Malle E. Immunohistochemical detection of hypochlorite-modified proteins in glomeruli of human membranous glomerulonephritis. Lab Invest. 2002;82:5-14 pubmed
    ..Here we demonstrate the presence of HOCl-modified proteins in glomeruli of patients with membranous glomerulonephritis using monoclonal antibodies that do not cross-react with other oxidative modifications...
  47. Stratta P, Bermond F, Guarrera S, Canavese C, Carturan S, Dall Omo A, et al. Interaction between gene polymorphisms of nitric oxide synthase and renin-angiotensin system in the progression of membranous glomerulonephritis. Nephrol Dial Transplant. 2004;19:587-95 pubmed
    ..Although previous studies have examined genetic risk associated with single gene variations, experiments assessing risk conferred by multiple gene variations are still scanty...
  48. Cattran D, Appel G, Hebert L, Hunsicker L, Pohl M, Hoy W, et al. Cyclosporine in patients with steroid-resistant membranous nephropathy: a randomized trial. Kidney Int. 2001;59:1484-90 pubmed
    ..Cyclosporine has been shown to be effective in cases of progressive MGN, but it has not been used in controlled studies at an early stage of the disease...
  49. Troyanov S, Wall C, Miller J, Scholey J, Cattran D. Idiopathic membranous nephropathy: definition and relevance of a partial remission. Kidney Int. 2004;66:1199-205 pubmed
    ..A complete remission (CR) confers an excellent long-term prognosis, but the quantitative benefits of partial remissions (PR) have not been defined...
  50. Freedman B, Spray B, Dunston G, Heise E. HLA associations in end-stage renal disease due to membranous glomerulonephritis: HLA-DR3 associations with progressive renal injury. Southeastern Organ Procurement Foundation. Am J Kidney Dis. 1994;23:797-802 pubmed
    b>Membranous glomerulonephritis (MGN) is the most common cause of idiopathic glomerulonephritis in American adults...
  51. Emsley H, Molloy J. Inflammatory demyelinating polyradiculoneuropathy associated with membranous glomerulonephritis and thrombocytopaenia. Clin Neurol Neurosurg. 2002;105:23-6 pubmed
    ..were also noted at the time of presentation-histopathological investigation of the former showed membranous glomerulonephritis as the basis for the protein loss...
  52. Mobbs R, Tuck R, Hurley B. Chronic inflammatory demyelinating polyneuropathy associated with membranous glomerulonephritis: case report. J Clin Neurosci. 2000;7:454-5 pubmed
    A case of Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) with Membranous Glomerulonephritis (MGN) is reported...
  53. Ivanyi B, Haszon I, Endreffy E, Szenohradszky P, Petri I, Kalmar T, et al. Childhood membranous nephropathy, circulating antibodies to the 58-kD TIN antigen, and anti-tubular basement membrane nephritis: an 11-year follow-up. Am J Kidney Dis. 1998;32:1068-74 pubmed
    ..The presented case is the fifth in the literature that displays reactivity with the 58-kd TIN antigen, and for which data on HLA antigens are reported...