immune system diseases

Summary

Summary: Disorders caused by abnormal or absent immunologic mechanisms, whether humoral, cell-mediated, or both.

Top Publications

  1. Ramagopalan S, Wotton C, Handel A, Yeates D, Goldacre M. Risk of venous thromboembolism in people admitted to hospital with selected immune-mediated diseases: record-linkage study. BMC Med. 2011;9:1 pubmed publisher
    ..We, therefore, decided to study the risk of deep vein thrombosis (DVT) and pulmonary embolism (PE) in people admitted to hospital with a range of immune-mediated diseases...
  2. Koshiol J, Lam T, Gridley G, Check D, Brown L, Landgren O. Racial differences in chronic immune stimulatory conditions and risk of non-Hodgkin's lymphoma in veterans from the United States. J Clin Oncol. 2011;29:378-85 pubmed publisher
    ..To examine underlying etiologic factors that may explain the racial disparity in non-Hodgkin's lymphoma (NHL) incidence patterns...
  3. Elliott D, Summers R, Weinstock J. Helminths as governors of immune-mediated inflammation. Int J Parasitol. 2007;37:457-64 pubmed
    ..This paper summarises work by multiple groups demonstrating that colonization with helminths alters immune reactivity and protects against disease from dysregulated inflammation...
  4. Weng X, Liu L, Barcellos L, Allison J, Herrinton L. Clustering of inflammatory bowel disease with immune mediated diseases among members of a northern california-managed care organization. Am J Gastroenterol. 2007;102:1429-35 pubmed
  5. Selgrade M. Immunotoxicity: the risk is real. Toxicol Sci. 2007;100:328-32 pubmed
    ..There is evidence that in utero exposure to cigarette smoke and arsenic but not PCBs is associated with increased risk of allergic disease as well. There is clearly potential for designing studies that could address both issues...
  6. Steinman R, Banchereau J. Taking dendritic cells into medicine. Nature. 2007;449:419-26 pubmed
    ..Here we present some medical implications of DC biology that account for illness and provide opportunities for prevention and therapy...
  7. Goldacre M, Wotton C, Yeates D. Cancer and immune-mediated disease in people who have had meningococcal disease: record-linkage studies. Epidemiol Infect. 2009;137:681-7 pubmed publisher
    ..53-0.89). Susceptibility to meningococcal disease was not associated with an altered risk of cancer. Occurrence of immune-mediated disease was, if anything, low in the large all-England cohort of people who had meningococcal disease...
  8. Shi Y, Hu G, Su J, Li W, Chen Q, Shou P, et al. Mesenchymal stem cells: a new strategy for immunosuppression and tissue repair. Cell Res. 2010;20:510-8 pubmed publisher
    ..Thus, our results provide novel information about the mechanisms of MSC-mediated immunosuppression and for better application of MSCs in treating tissue injuries induced by immune responses...
  9. Zhang Y, Su H. Designs for massively parallel sequencing approaches to identify causal mutations in human immune disorders. Methods Mol Biol. 2013;979:175-87 pubmed publisher
    ..We discuss optimal experimental designs for sample selection and sequencing approaches, as well as key aspects of data analysis such as filtering and prioritization of identified variants...

More Information

Publications62

  1. Takahashi H, Tsuboi H, Asashima H, Hirota T, Kondo Y, Moriyama M, et al. cDNA microarray analysis identifies NR4A2 as a novel molecule involved in the pathogenesis of Sjögren's syndrome. Clin Exp Immunol. 2017;190:96-109 pubmed publisher
    ..NR4A2 seems to promote Th17 polarization via increased expression and intranuclear localization in CD4+ T cells of SS patients, which could play a critical role in the pathogenesis of SS. ..
  2. Alqahtani M, Mukundan D. Current understanding of fever and host immunity. Curr Opin Pediatr. 2011;23:115-20 pubmed publisher
    ..Inherited and acquired immune system dysfunctions associated with fever are reviewed. Recent evidence of best practices in the diagnosis and treatment of fever caused by infections in children are also discussed...
  3. Srinivasan A, Wang C, Yang J, Shenep J, Leung W, Hayden R. Symptomatic parainfluenza virus infections in children undergoing hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2011;17:1520-7 pubmed publisher
    ..002), use of steroids (P < .0001), mechanical ventilation (P < .0001), and ALC <100 cells/?L at the onset of infection (P = .01). PIV infection causes significant morbidity and mortality in children undergoing HSCT...
  4. Purchiaroni F, Tortora A, Gabrielli M, Bertucci F, Gigante G, Ianiro G, et al. The role of intestinal microbiota and the immune system. Eur Rev Med Pharmacol Sci. 2013;17:323-33 pubmed
    ..Several data confirm that gut microbiota is engaged in a dynamic interaction with the intestinal innate and adaptive immune system, affecting different aspects of its development and function...
  5. Schwartz J, Winters J, Padmanabhan A, Balogun R, Delaney M, Linenberger M, et al. Guidelines on the use of therapeutic apheresis in clinical practice-evidence-based approach from the Writing Committee of the American Society for Apheresis: the sixth special issue. J Clin Apher. 2013;28:145-284 pubmed publisher
  6. Canani R, Costanzo M, Leone L, Bedogni G, Brambilla P, Cianfarani S, et al. Epigenetic mechanisms elicited by nutrition in early life. Nutr Res Rev. 2011;24:198-205 pubmed publisher
    ..More recently, the epigenetic mechanisms elicited by probiotics through the production of SCFA are hypothesised to be the key to understand how they mediate their numerous health-promoting effects from the gut to the peripheral tissues...
  7. Germena G, Hirsch E. PI3Ks and small GTPases in neutrophil migration: two sides of the same coin. Mol Immunol. 2013;55:83-6 pubmed publisher
    ..In this review we will describe the role of these molecules and the interaction between their signal cascades in leukocyte polarization and amoeboid migration...
  8. Obulkasim M, Turdi A, Amat N, Haxim M, Eziz R, Haji H, et al. Neuroendocrine-immune disorder in type 2 diabetic patients with retinopathy. Clin Exp Pharmacol Physiol. 2011;38:229-32 pubmed publisher
    ..There was no significant difference in plasma concentrations of DA and NE among all three groups (P>0.05). 4. Our data suggest that HPA and immune dysfunction might play a role in the development and/or progression of PDR...
  9. Shugart Y, Wang Y, Jia W, Zeng Y. GWAS signals across the HLA regions: revealing a clue for common etiology underlying infectious tumors and other immunity diseases. Chin J Cancer. 2011;30:226-30 pubmed
    ..This finding is suggestive for testing a hypothesis of a common etiology of infectious tumors and other immunity diseases. ..
  10. Droz N, Gilardin L, Cacoub P, Berenbaum F, Wendling D, Godeau B, et al. Kinetic profiles and management of hepatitis B virus reactivation in patients with immune-mediated inflammatory diseases. Arthritis Care Res (Hoboken). 2013;65:1504-14 pubmed publisher
    ..We aimed to describe HBV reactivation in patients receiving treatment for immune-mediated inflammatory diseases (IMIDs) and to evaluate a predefined algorithm for its prevention...
  11. Fogli L, Sundrud M, Goel S, Bajwa S, Jensen K, Derudder E, et al. T cell-derived IL-17 mediates epithelial changes in the airway and drives pulmonary neutrophilia. J Immunol. 2013;191:3100-11 pubmed publisher
  12. Cantacessi C, Young N, Nejsum P, Jex A, Campbell B, Hall R, et al. The transcriptome of Trichuris suis--first molecular insights into a parasite with curative properties for key immune diseases of humans. PLoS ONE. 2011;6:e23590 pubmed publisher
    ..Importantly, the T. suis transcriptome characterised herein provides a curated resource for detailed studies of the immuno-molecular biology of this parasite, and will underpin future genomic and proteomic explorations. ..
  13. Lins K, Vale M, Ribeiro R, Costa Lotufo L. Proinflammatory activity of an alginate isolated from Sargassum vulgare. Carbohydr Polym. 2013;92:414-20 pubmed publisher
    ..Our data suggest that SVHV has proinflammatory activity dependent of the activation of resident cells, being the macrophages the main cells involved...
  14. Tang A, Balzli C, Caballero A, McCormick C, Taylor S, O Callaghan R. Staphylococcus aureus infection of the rabbit cornea following topical administration. Curr Eye Res. 2012;37:1075-83 pubmed publisher
    ..To determine the ability of diverse S. aureus strains to infect the rabbit cornea following topical inoculation, with special emphasis on a strain of unusual virulence...
  15. Harizi H. Reciprocal crosstalk between dendritic cells and natural killer cells under the effects of PGE2 in immunity and immunopathology. Cell Mol Immunol. 2013;10:213-21 pubmed publisher
    ..This review highlights the effects of PGE2 on DC-NK cell crosstalk and its subsequent impact on immune regulations in normal and immunopathological processes...
  16. Agostini M, Tucci P, Melino G. Cell death pathology: perspective for human diseases. Biochem Biophys Res Commun. 2011;414:451-5 pubmed publisher
    ..Thus, modulation of the apoptotic process and of cell death in general, is a potential therapeutic approach for the treatment of several human pathologies...
  17. Apt A. Are mouse models of human mycobacterial diseases relevant? Genetics says: 'yes!'. Immunology. 2011;134:109-15 pubmed publisher
    ..In the opinion of the author, refined mouse models of mycobacterial diseases are extremely useful for modelling the corresponding human conditions, if genetic diversity is taken into account...
  18. Agostoni C, Rise P, Marangoni F. Membrane composition and cellular responses to fatty acid intakes and factors explaining the variation in response. Nestle Nutr Inst Workshop Ser. 2013;77:111-20 pubmed publisher
    ..Accordingly, different amounts of dietary PUFA may be necessary to meet the requirements for these nutrients in development and disease prevention on an individual basis...
  19. Hua M, Lai M, Kuo M, Yao T, Huang J, Chen S. Decreased interleukin-10 secretion by peripheral blood mononuclear cells in children with irritable bowel syndrome. J Pediatr Gastroenterol Nutr. 2011;52:376-81 pubmed publisher
    ..The aim of the present study was to evaluate proinflammatory and anti-inflammatory cytokine levels in children with irritable bowel syndrome (IBS)...
  20. Beghin D, Cournot M, Vauzelle C, Elefant E. Paternal exposure to methotrexate and pregnancy outcomes. J Rheumatol. 2011;38:628-32 pubmed publisher
    ..To assess the risk of major malformation in the case of paternal exposure to methotrexate (MTX) at the time of conception...
  21. Cusack K, Stoffel R. S1P(1) receptor agonists: Assessment of selectivity and current clinical activity. Curr Opin Drug Discov Devel. 2010;13:481-8 pubmed
    ..This review focuses on the development of these compounds and the role of S1P receptor family selectivity...
  22. Bayry J, Radstake T. Immune-mediated inflammatory diseases: progress in molecular pathogenesis and therapeutic strategies. Expert Rev Clin Immunol. 2013;9:297-9 pubmed publisher
    ..The workshop was preceded by a masterclass that covered the last 15 years of IL-17/Th17 research and provided an overview on future therapeutics to battle immune-mediated inflammatory diseases...
  23. Schirmer M, Duftner C, Dejaco C. Challenges in the diagnosis of chronic immune-mediated rheumatic diseases. Discov Med. 2013;15:160-5 pubmed
    ..Specific interest is given to differentiate infections from early onset or relapse of immune-mediated rheumatic diseases...
  24. List F, Kessler P, Volk T. [Regional anesthesia in patients with pre-existing infections or immunosuppression]. Anaesthesist. 2013;62:175-82 pubmed publisher
    ..A strict contraindication in patients with pre-existing systemic or local infections seems unjustifiable. A clear and documented risk-benefit ratio in these patients is mandatory...
  25. Zhang E, Kong K, Altman A. The yin and yang of protein kinase C-theta (PKC?): a novel drug target for selective immunosuppression. Adv Pharmacol. 2013;66:267-312 pubmed publisher
    ..Early progress in developing such drugs is being made, but additional studies on the role of PKC? in the human immune system are urgently needed...
  26. Ballesta A, Innominato P, Dallmann R, Rand D, Lévi F. Systems Chronotherapeutics. Pharmacol Rev. 2017;69:161-199 pubmed publisher
  27. Sepiashvili R. [IMMUNOREHABILITOLOGY: A LOOK FROM THE SOURCES TO THE FUTURE. FROM IMMUNOTHERAPY TO PERSONALIZED TARGETED IMMUNOREHABLITATION]. Georgian Med News. 2017;:7-19 pubmed
    ..In this paper, the author returns to the roots and recalls the way that medical science has gone before coming to understand immunorehablitology and tells readers about current successes and its development prospects...
  28. Cheuk W, Tam F, Chan A, Luk I, Yuen A, Chan W, et al. Idiopathic cervical fibrosis--a new member of IgG4-related sclerosing diseases: report of 4 cases, 1 complicated by composite lymphoma. Am J Surg Pathol. 2010;34:1678-85 pubmed publisher
    ..Thus lymphoma can supervene in the chronic inflammatory background similar to that recently documented for IgG4-related sclerosing disease of the ocular adnexa...
  29. Hirata T, Narumiya S. Prostanoids as regulators of innate and adaptive immunity. Adv Immunol. 2012;116:143-74 pubmed publisher
    ..Here, we review the role of prostanoids in regulating immunity, their involvement in immunopathology, and areas of insight that may lead to new therapeutic opportunities...
  30. Ito A, Miura N, Kimura Y, Maeda S, Suzuki K, Kitagawa W, et al. Myeloperoxidase anti-cytoplasmic antibody related crescentic glomerulonephritis in a patient with IgG3? monoclonal immunoglobulin deposition disease with membranous features. Intern Med. 2012;51:2393-7 pubmed
    ..This is the first English-language case report describing MPO-ANCA positive crescentic glomerulonephritis in a patient demonstrating monoclonal immunoglobulin deposition disease with mainly membranous features...
  31. Sacco R, Lenti C, Saccani M, Curatolo P, Manzi B, Bravaccio C, et al. Cluster analysis of autistic patients based on principal pathogenetic components. Autism Res. 2012;5:137-47 pubmed publisher
    ..7 x 10(-45)), followed by "stereotypic behaviors." These patient clusters may likely differ in genetic and immune underpinnings, developmental trajectories, and response to treatment...
  32. Navarro S, Ferreira I, Loukas A. The hookworm pharmacopoeia for inflammatory diseases. Int J Parasitol. 2013;43:225-31 pubmed publisher
  33. Hilgaertner J, He X, Camacho D, Badowski M, Witten M, Harris D. The influence of hydrocarbon composition and exposure conditions on jet fuel-induced immunotoxicity. Toxicol Ind Health. 2011;27:887-98 pubmed publisher
    ..Both of these changes in exposure reduced but did not eliminate the deleterious effects on the immune system of exposed mice...
  34. Molinelli E, Campanati A, Ganzetti G, Offidani A. Biologic Therapy in Immune Mediated Inflammatory Disease: Basic Science and Clinical Concepts. Curr Drug Saf. 2016;11:35-43 pubmed
    ..The dosing regimens, methods of administration, pharmacodynamics profiles, and side effects of the currently licensed TNFα antagonists and IL12/IL23 inhibitor are discussed in detail. ..
  35. Reichert S, McKay E, Moldenhauer J. Identification of a novel nonsense mutation in the FOXP3 gene in a fetus with hydrops--Expanding the phenotype of IPEX syndrome. Am J Med Genet A. 2016;170A:226-32 pubmed publisher
    ..These two cases further expand the fetal phenotype of IPEX Syndrome. While rare, IPEX syndrome should be another potential differential when considering the onset of unexplained hydrops in a male fetus...
  36. Stagg J, Galipeau J. Mechanisms of immune modulation by mesenchymal stromal cells and clinical translation. Curr Mol Med. 2013;13:856-67 pubmed
    ..Finally, we review the literature on the molecular pathways governing MSC homing and discuss recent clinical data on the use of MSCs for treatment of GvHD, MS and Crohn's disease...
  37. de Prost N, Parrot A, Cuquemelle E, Picard C, Antoine M, Fleury Feith J, et al. Diffuse alveolar hemorrhage in immunocompetent patients: etiologies and prognosis revisited. Respir Med. 2012;106:1021-32 pubmed publisher
    ..More than 100 causes of DAH have been reported. However, the relative frequency and the differential presentation of those causes have been poorly documented, as well as their respective prognosis...
  38. Romero R, Korzeniewski S. Are infants born by elective cesarean delivery without labor at risk for developing immune disorders later in life?. Am J Obstet Gynecol. 2013;208:243-6 pubmed publisher
  39. Voswinkel J, Francois S, Simon J, Benderitter M, Gorin N, Mohty M, et al. Use of mesenchymal stem cells (MSC) in chronic inflammatory fistulizing and fibrotic diseases: a comprehensive review. Clin Rev Allergy Immunol. 2013;45:180-92 pubmed publisher
    ..These findings are instructional for the management of refractory inflammatory bowel diseases that are characterized by similar clinical and immunopathological features...
  40. Khan M, Colby T, Viggiano R, Fonseca R. Treatment with bortezomib of a patient having hyper IgG4 disease. Clin Lymphoma Myeloma Leuk. 2010;10:217-9 pubmed publisher
    ..We report a patient with recurrent pulmonary infiltration with IgG4 plasma cells, consistent with hyper IgG4 disease, who was successfully treated using a bortezomib-based combination with minimal therapy-related toxicities...
  41. Hess J, Greenberg N. The role of nucleotides in the immune and gastrointestinal systems: potential clinical applications. Nutr Clin Pract. 2012;27:281-94 pubmed publisher
    ..In an effort to build on this, the current review presents the data to support potential clinical applications for nucleotides in enteral nutrition that may contribute to improved outcomes in physiologically stressed patients...
  42. Guerrero A, Zarpelon A, Zaperlon A, Vieira S, Pinto L, Ferreira S, et al. The role of PAF/PAFR signaling in zymosan-induced articular inflammatory hyperalgesia. Naunyn Schmiedebergs Arch Pharmacol. 2013;386:51-9 pubmed publisher
    ..Finally, targeting PAF action (e.g., with a PAFR antagonist) might provide a useful therapeutic approach to inhibit articular inflammatory hyperalgesia...
  43. d Hennezel E, Bin Dhuban K, Torgerson T, Piccirillo C, Piccirillo C. The immunogenetics of immune dysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome. J Med Genet. 2012;49:291-302 pubmed publisher
    ..In this review, the genetic, immunological and clinical characteristics of IPEX syndrome are described, and the impact of heritable mutations on the function of Treg cells highlighted...
  44. Menard C, Tarte K. Immunoregulatory properties of clinical grade mesenchymal stromal cells: evidence, uncertainties, and clinical application. Stem Cell Res Ther. 2013;4:64 pubmed publisher
  45. Maheshwari S, Brylinski M. Across-proteome modeling of dimer structures for the bottom-up assembly of protein-protein interaction networks. BMC Bioinformatics. 2017;18:257 pubmed publisher
  46. Nahid M, Satoh M, Chan E. MicroRNA in TLR signaling and endotoxin tolerance. Cell Mol Immunol. 2011;8:388-403 pubmed publisher
    ..Modulation of these microRNAs may affect TLR pathway activation and help to develop therapeutics against inflammatory diseases...
  47. Lehman J, Smyrk T, Pittelkow M. Increased immunoglobulin (Ig) G4-positive plasma cell density and IgG4/IgG ratio are not specific for IgG4-related disease in the skin. Am J Clin Pathol. 2014;141:234-8 pubmed publisher
    ..We aimed to determine whether increased cutaneous IgG4+ PCs or IgG4/IgG ratio is specific for IgG4-RD...
  48. Soulet D, Cicchetti F. The role of immunity in Huntington's disease. Mol Psychiatry. 2011;16:889-902 pubmed publisher
    ..As part of this discussion, we revisit the clinical data on the anti-inflammatory drug trials in HD and propose new experimental approaches to interrogate the role of immunity in this currently incurable disorder...
  49. Angioi A, Fervenza F, Sethi S, Zhang Y, Smith R, Murray D, et al. Diagnosis of complement alternative pathway disorders. Kidney Int. 2016;89:278-88 pubmed publisher
    ..The identification of the underlying defect in the alternative pathway based on this comprehensive analysis will allow treatment to be directed to the site of dysregulation. ..
  50. Hernandez J, Leung G, McKay D. Cestode regulation of inflammation and inflammatory diseases. Int J Parasitol. 2013;43:233-43 pubmed publisher
  51. Rodríguez Cortez V, Hernando H, de la Rica L, Vento R, Ballestar E. Epigenomic deregulation in the immune system. Epigenomics. 2011;3:697-713 pubmed publisher
    ..It is also discussed how epigenomic analysis can help to understand the molecular basis of these diseases and how this information can be used in the clinical setting...
  52. Arenas J. The role of bacterial lipopolysaccharides as immune modulator in vaccine and drug development. Endocr Metab Immune Disord Drug Targets. 2012;12:221-35 pubmed
    ..The purpose of this review is to examine the progress in the generation of new LPS-based molecules and their therapeutic potential...
  53. Martín Santiago A, Hervás J, Hervás D, Rosell A, Caimari M, de Carlos J, et al. Diagnostic value of the skin lesions in immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. Pediatr Dermatol. 2013;30:e221-2 pubmed publisher
    ..IPEX syndrome is a rare, often fatal recessive disease caused by mutations in the FOXP3 gene on the X chromosome (Xp11.23-q13.3). ..