cetirizine

Summary

Summary: A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.

Top Publications

  1. Takahashi H, Ishida Yamamoto A, Iizuka H. Effects of bepotastine, cetirizine, fexofenadine, and olopatadine on histamine-induced wheal-and flare-response, sedation, and psychomotor performance. Clin Exp Dermatol. 2004;29:526-32 pubmed
    ..designed a double-blind, placebo-controlled, crossover study to compare the inhibitory effects of bepotastine, cetirizine, fexofenadine, and olopatadine on histamine-induced flare-and-wheal response...
  2. Azhagvuel S, Sekar R. Method development and validation for the simultaneous determination of cetirizine dihydrochloride, paracetamol, and phenylpropanolamine hydrochloride in tablets by capillary zone electrophoresis. J Pharm Biomed Anal. 2007;43:873-8 pubmed
    ..zone electrophoresis (CZE) method has been developed for the simultaneous separation and determination of cetirizine dihydrochloride (CTZ), paracetamol (PARA), and phenylpropanolamine hydrochloride (PPA) in tablets...
  3. Dasgupta A, Wells A, Datta P. False-positive serum tricyclic antidepressant concentrations using fluorescence polarization immunoassay due to the presence of hydroxyzine and cetirizine. Ther Drug Monit. 2007;29:134-9 pubmed
    A recent report indicates that hydroxyzine and its active metabolite cetirizine interfere with the PENTINA carbamazepine assay...
  4. Kuna P, Bachert C, Nowacki Z, Van Cauwenberge P, Agache I, Fouquert L, et al. Efficacy and safety of bilastine 20 mg compared with cetirizine 10 mg and placebo for the symptomatic treatment of seasonal allergic rhinitis: a randomized, double-blind, parallel-group study. Clin Exp Allergy. 2009;39:1338-47 pubmed publisher
    ..To assess and compare the efficacy and safety of bilastine 20 mg vs. cetirizine 10 mg and placebo in relieving the symptoms of seasonal allergic rhinitis (SAR)...
  5. Temizel E, Cihan H, Akhtardanesh B, Aytug N. Effect of prednisolone and cetirizine on D. farinae and histamine-induced wheal and flare response in healthy dogs. Tierarztl Prax Ausg K Kleintiere Heimtiere. 2011;39:25-30 pubmed
    ..The aim of the present study was to compare the effects of cetirizine and prednisolone on IDT results. Thirty healthy dogs (average age 5.9 ± 0...
  6. Gowekar N, Pande V, Kasture A, Tekade A, Chandorkar J. Spectrophotometric estimation of ambroxol and cetirizine hydrochloride from tablet dosage form. Pak J Pharm Sci. 2007;20:250-1 pubmed
    Fixed dose combination tablets containing ambroxol HCl and cetirizine HCl are clinically used as mucolytic and antiallergic...
  7. Shimizu T, Nishihira J, Watanabe H, Abe R, Ishibashi T, Shimizu H. Cetirizine, an H1-receptor antagonist, suppresses the expression of macrophage migration inhibitory factor: its potential anti-inflammatory action. Clin Exp Allergy. 2004;34:103-9 pubmed
    H1-receptor antagonists are often effective in the treatment of allergic disorders such as atopic dermatitis. Cetirizine, a putative H1-receptor antagonist, has recently been shown to have anti-inflammatory properties through the ..
  8. Jaber A, Al Sherife H, Al Omari M, Badwan A. Determination of cetirizine dihydrochloride, related impurities and preservatives in oral solution and tablet dosage forms using HPLC. J Pharm Biomed Anal. 2004;36:341-50 pubmed
    An HPLC method was developed and validated for the determination of cetirizine dihydrochloride (CZ) as well as its related impurities in commercial oral solution and tablet formulations...
  9. Shohrati M, Davoudi S, Keshavarz S, Sadr B, Tajik A. Cetirizine, doxepine, and hydroxyzine in the treatment of pruritus due to sulfur mustard: a randomized clinical trial. Cutan Ocul Toxicol. 2007;26:249-55 pubmed
    A 4-week randomized, double-blind safety and efficacy study was conducted to compare the safety and efficacy of cetirizine, doxepine, and hydroxyzine 5 in the treatment of chronic pruritus due to sulfur mustard...

More Information

Publications62

  1. Llupià J, Gras J, Llenas J. Comparative antiallergic effects of second-generation H1-antihistamines ebastine, cetirizine and loratadine in preclinical models. Arzneimittelforschung. 2003;53:93-7 pubmed
    Ebastine (CAS 90729-43-4), cetirizine (CAS 83881-51-0) and loratadine (CAS 79794-75-5) are second generation H1-antihistamines of proven efficacy for treating allergy...
  2. Lee C, Sun H, Lu K, Ku M, Lue K. The comparison of cetirizine, levocetirizine and placebo for the treatment of childhood perennial allergic rhinitis. Pediatr Allergy Immunol. 2009;20:493-9 pubmed publisher
    b>Cetirizine (Zyrtec) is a potent and long-acting second-generation histamine H1- receptor antagonist for the treatment of allergic disease, such as allergic rhinitis and chronic idiopathic urticaria, in adult and child...
  3. Hadad G, Emara S, Mahmoud W. Development and validation of a stability-indicating RP-HPLC method for the determination of paracetamol with dantrolene or/and cetirizine and pseudoephedrine in two pharmaceutical dosage forms. Talanta. 2009;79:1360-7 pubmed publisher
    ..RP-HPLC) method has been developed which can separate and accurately quantitate paracetamol, dantrolene, cetirizine and pseudoephedrine...
  4. Garg G, Thami G. Comparative efficacy of cetirizine and levocetirizine in chronic idiopathic urticaria. J Dermatolog Treat. 2007;18:23-4 pubmed
    ..Newer hydroxyzine derivatives such as cetirizine and levocetirizine have been found to be equally efficacious in preclinical studies in patients with chronic ..
  5. Kenawi I, Barsoum B, Youssef M. Drug-drug interaction between diclofenac, cetirizine and ranitidine. J Pharm Biomed Anal. 2005;37:655-61 pubmed
    The interactions between diclofenac (1), cetirizine (2) and ranitidine (3) were investigated by thermal analyses and UV, IR and (1)H NMR spectroscopic studies...
  6. Horak F, Zieglmayer P, Zieglmayer R, Lemell P. The effects of bilastine compared with cetirizine, fexofenadine, and placebo on allergen-induced nasal and ocular symptoms in patients exposed to aeroallergen in the Vienna Challenge Chamber. Inflamm Res. 2010;59:391-8 pubmed publisher
    This double-blind cross-over study compared the potential of bilastine, cetirizine, and fexofenadine to relieve the symptoms of allergic rhinitis...
  7. Nordness M, Zacharisen M. High dose cetirizine: a case report. Cutis. 2003;71:396 pubmed
    We report the case of a 46-year-old man who tolerated 50 mg per day of cetirizine for the treatment of chronic idiopathic urticaria...
  8. Chang Y, Kwon H, Cho S, Kim Y, Min K. A case of urticaria induced by both hydroxyzine and cetirizine but not by levocetirizine. Allergy. 2007;62:819-21 pubmed
  9. Karakus S, Küçükgüzel I, Kucukguzel S. Development and validation of a rapid RP-HPLC method for the determination of cetirizine or fexofenadine with pseudoephedrine in binary pharmaceutical dosage forms. J Pharm Biomed Anal. 2008;46:295-302 pubmed
    ..forms containing binary mixtures of pseudoephedrine hydrochloride (PSE) with fexofenadine hydrochloride (FEX) or cetirizine dihydrochloride (CET)...
  10. Larsson A, Fumagalli F, DiGennaro A, Andersson M, Lundberg J, Edenius C, et al. A new class of nitric oxide-releasing derivatives of cetirizine; pharmacological profile in vascular and airway smooth muscle preparations. Br J Pharmacol. 2007;151:35-44 pubmed
    ..properties of compounds NCX 1512 and NCX 1514, synthesized by linking the histamine H1-receptor antagonist cetirizine to NO-releasing spacer groups, are reported...
  11. Ahuja R, Gupta R, Gupta G, Shrivastava P. A comparative analysis of cetirizine, gabapentin and their combination in the relief of post-burn pruritus. Burns. 2011;37:203-7 pubmed publisher
    ..of gabapentin in post-burn itch management the current study was undertaken to individually evaluate gabapentin, cetirizine and their combination in relieving itch...
  12. He Y, Liu Y, Zeng S. Stereoselective and multiple carrier-mediated transport of cetirizine across Caco-2 cell monolayers with potential drug interaction. Chirality. 2010;22:684-92 pubmed publisher
    The aim of this study was to explore potential transport mechanisms of cetirizine enantiomers across Caco-2 cells. Cetirizine displayed polarized transport at concentrations ranging from 4.0 to 80...
  13. Weber Schoendorfer C, Schaefer C. The safety of cetirizine during pregnancy. A prospective observational cohort study. Reprod Toxicol. 2008;26:19-23 pubmed publisher
    To assess the safety of cetirizine during pregnancy. A prospective observational cohort study with data of the Berlin teratology information center from 1992 until 2006...
  14. Schoepke N, Church M, Maurer M. The inhibition by levocetirizine and fexofenadine of the histamine-induced wheal and flare response in healthy Caucasian and Japanese volunteers. Acta Derm Venereol. 2013;93:286-93 pubmed publisher
    ..The plasma levels of levocetirizine rose more quickly, reached higher levels, were more consistent and decreased slower than those of fexofenadine. There were no clinically significant ethnic differences in responsiveness to the drugs...
  15. Li F, Ji R, Chen X, You B, Pan Y, Su J. Cetirizine dihydrochloride loaded microparticles design using ionotropic cross-linked chitosan nanoparticles by spray-drying method. Arch Pharm Res. 2010;33:1967-73 pubmed publisher
    To control the release rate and mask the bitter taste, cetirizine dihydrochloride (CedH) was entrapped within chitosan nanoparticles (CS-NPs) using an ionotropic gelation process, followed by microencapsulation to produce CS matrix ..
  16. Takahashi H, Zhang Y, Morita E. Evaluation of the antihistamine effects of olopatadine, cetirizine and fexofenadine during a 24 h period: a double-blind, randomized, crossover, placebo-controlled comparison in skin responses induced by histamine iontophoresis. Arch Dermatol Res. 2008;300:291-5 pubmed publisher
    Potency of the antihistamine effects of olopatadine, cetirizine and fexofenadine in standard-dose application were compared from 11.5 to 24 h after application...
  17. Sugiura K, Hirai S, Suzuki T, Usuda T, Kondo T, Azumi T, et al. Evaluation of cetirizine hydrochloride-based therapeutic strategy for chronic urticaria. Nagoya J Med Sci. 2008;70:97-106 pubmed
    We investigated the suitability of cetirizine HCl (cetirizine) for the initial treatment of chronic urticaria...
  18. Gillard M, Benedetti M, Chatelain P, Baltes E. Histamine H1 receptor occupancy and pharmacodynamics of second generation H1-antihistamines. Inflamm Res. 2005;54:367-9 pubmed
  19. Fraunfelder F, Fraunfelder F. Oculogyric crisis in patients taking cetirizine. Am J Ophthalmol. 2004;137:355-7 pubmed
    To report oculogyric crisis in patients receiving cetirizine and inform clinicians on the characteristics of this drug-induced ocular side effect...
  20. Tashiro M, Kato M, Miyake M, Watanuki S, Funaki Y, Ishikawa Y, et al. Dose dependency of brain histamine H(1) receptor occupancy following oral administration of cetirizine hydrochloride measured using PET with [11C]doxepin. Hum Psychopharmacol. 2009;24:540-8 pubmed publisher
    ..of the present study is to measure histamine H(1) receptor (H(1)R) occupancy following oral administration of cetirizine (10 and 20 mg) in order to examine dose dependency...
  21. Lew B, Haw C, Lee M. Cutaneous drug eruption from cetirizine and hydroxyzine. J Am Acad Dermatol. 2004;50:953-6 pubmed
    ..The antihistamines cetirizine and hydroxyzine are piperazine derivatives, on the structural basis of an ethylenediamine, but the cross-..
  22. Hasan S, Al Ali H, Al Qubaisi M, Zobir Hussein M, Ismail M, Zainal Z, et al. Controlled-release formulation of antihistamine based on cetirizine zinc-layered hydroxide nanocomposites and its effect on histamine release from basophilic leukemia (RBL-2H3) cells. Int J Nanomedicine. 2012;7:3351-63 pubmed publisher
    A controlled-release formulation of an antihistamine, cetirizine, was synthesized using zinc-layered hydroxide as the host and cetirizine as the guest...
  23. Cravo M, Goncalo M, Figueiredo A. Fixed drug eruption to cetirizine with positive lesional patch tests to the three piperazine derivatives. Int J Dermatol. 2007;46:760-2 pubmed
    The H1-antihistamine cetirizine, a piperazine derivative widely used in daily practice, is rarely the cause of cutaneous drug reaction...
  24. Tashiro M, Sakurada Y, Iwabuchi K, Mochizuki H, Kato M, Aoki M, et al. Central effects of fexofenadine and cetirizine: measurement of psychomotor performance, subjective sleepiness, and brain histamine H1-receptor occupancy using 11C-doxepin positron emission tomography. J Clin Pharmacol. 2004;44:890-900 pubmed
    ..This study compared the sedative profiles of the second-generation antihistamines, fexofenadine and cetirizine, using 3 different criteria: subjective sleepiness evaluated by the Stanford Sleepiness Scale, objective ..
  25. Wang D, Hanotte F, De Vos C, Clement P. Effect of cetirizine, levocetirizine, and dextrocetirizine on histamine-induced nasal response in healthy adult volunteers. Allergy. 2001;56:339-43 pubmed
    b>Cetirizine, an effective H1-receptor antagonist, is a racemate mixture of two enantiomers: levocetirizine (R enantiomer) and dextrocetirizine (S enantiomer).
  26. Hindmarch I, Johnson S, Meadows R, Kirkpatrick T, Shamsi Z. The acute and sub-chronic effects of levocetirizine, cetirizine, loratadine, promethazine and placebo on cognitive function, psychomotor performance, and weal and flare. Curr Med Res Opin. 2001;17:241-55 pubmed
    ..the central and peripheral H1 inhibitory effects of acute and sub-chronic doses of levocetirizine (L-CTZ), cetirizine (CTZ), loratadine (LOR) and promethazine (PRM) versus placebo, using a battery of psychomotor and cognitive ..
  27. Karppinen A, Kautiainen H, Petman L, Burri P, Reunala T. Comparison of cetirizine, ebastine and loratadine in the treatment of immediate mosquito-bite allergy. Allergy. 2002;57:534-7 pubmed
    ..Whealing is mediated by antisaliva immunoglobulin (Ig)E antibodies and histamine. Cetirizine, ebastine and loratadine have earlier shown effects on mosquito-bite reactions but no comparative studies exist...
  28. Taglialatela M, Pannaccione A, Castaldo P, Giorgio G, Zhou Z, January C, et al. Molecular basis for the lack of HERG K+ channel block-related cardiotoxicity by the H1 receptor blocker cetirizine compared with other second-generation antihistamines. Mol Pharmacol. 1998;54:113-21 pubmed
    ..of K+ channels encoded by the human ether-a-go-go related gene (HERG) by the piperazine H1 receptor antagonist cetirizine has been examined and compared with that of other second-generation antihistamines (astemizole, terfenadine, and ..
  29. Shamsi Z, Kimber S, Hindmarch I. An investigation into the effects of cetirizine on cognitive function and psychomotor performance in healthy volunteers. Eur J Clin Pharmacol. 2001;56:865-71 pubmed
    The cognitive and psychomotor effects of 2.5, 5 and 10 mg cetirizine, a second-generation H1 receptor antagonist, were compared with loratadine 10, 20 and 40 mg, promethazine 25 mg and placebo in 24 healthy volunteers in a double-blind, ..
  30. Lai D, Lue K, Hsieh J, Lin K, Lee H. The comparison of the efficacy and safety of cetirizine, oxatomide, ketotifen, and a placebo for the treatment of childhood perennial allergic rhinitis. Ann Allergy Asthma Immunol. 2002;89:589-98 pubmed
    There has been no study comparing the long-term effects of ketotifen, oxatomide, and cetirizine for the treatment of perennial allergic rhinitis among children...
  31. Assouère M, Mazereeuw Hautier J, Bonafe J. [Cutaneous drug eruption with two antihistaminic drugs of a same chemical family: cetirizine and hydroxyzine]. Ann Dermatol Venereol. 2002;129:1295-8 pubmed
    ..first case of cutaneous drug eruption as fixed drug eruption with 2 antihistamines of the same chemical family: cetirizine and hydroxyzine...
  32. Zhou S, Ding J, Zheng C, Wang H, Huang Z. [Efficacy and safety of Mizolastine in the treatment of perennial allergic rhinitis]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2007;21:491-3 pubmed
    ..Multicentric random Double-blind parallel-controlled study was adopted, and compared with placebo and Cetirizine. Patients (n = 177) were grouped, seventy-two in Mizolastine group, sixty-nine in Cetirizine and thirty-six in ..
  33. Barbanoj M, García Gea C, Antonijoan R, Izquierdo I, Donado E, Pérez I, et al. Evaluation of the cognitive, psychomotor and pharmacokinetic profiles of rupatadine, hydroxyzine and cetirizine, in combination with alcohol, in healthy volunteers. Hum Psychopharmacol. 2006;21:13-26 pubmed
    ..six treatments: (a) placebo (PLA), (b) ALC alone and ALC in combination with: (c) hydroxyzine 25 mg (HYD), (d) cetirizine 10 mg (CET), (e) RUP 10 mg or (f) RUP 20 mg...
  34. Arayne M, Sultana N, Mirza A, Siddiqui F. Simultaneous determination of gliquidone, fexofenadine, buclizine, and levocetirizine in dosage formulation and human serum by RP-HPLC. J Chromatogr Sci. 2010;48:382-5 pubmed
    ..Thus, the proposed method is suitable for the simultaneous analysis of active ingredients in tablet dosage forms and human serum. ..
  35. Qadir S, Raza N, Rahman S. Paederus dermatitis in Sierra Leone. Dermatol Online J. 2006;12:9 pubmed
    ..Patients in Group A were treated with topical diflucortolone valerate 0.001 percent and oral cetirizine hydrochloride; patients in group B were given oral ciprofloxacin in addition...
  36. Zhou J, Luo P, Chen S, Meng L, Sun C, Du Q, et al. Enantioseparation of Six Antihistamines with Immobilized Cellulose Chiral Stationary Phase by HPLC. J Chromatogr Sci. 2016;54:531-5 pubmed publisher
    ..separation of the enantiomers of six antihistamines, doxylamine, carbinoxamine, dioxopromethazine, oxomemazine, cetirizine and hydroxyzine...
  37. Ikeda Sagara M, Ozaki T, Shahid M, Morioka E, Wada K, Honda K, et al. Induction of prolonged, continuous slow-wave sleep by blocking cerebral H? histamine receptors in rats. Br J Pharmacol. 2012;165:167-82 pubmed publisher
    ..c.v. infusions. Effects of classic (d-chlorpheniramine; d-CPA) and second-generation (cetirizine) antihistamines on sleep were compared after i.p. injections or continuous i.c.v. infusions into rats...
  38. Elzainy A, Gu X, Simons F, Simons K. Cetirizine from topical phosphatidylcholine-hydrogenated liposomes: evaluation of peripheral antihistaminic activity and systemic absorption in a rabbit model. AAPS J. 2004;6:e18 pubmed
    b>Cetirizine, an effective, minimally sedating, second-generation H1-antihistamine is widely used orally to treat allergic skin disorders...
  39. Mahajan V, Sharma N, Sharma V. Fixed drug eruption: a novel side-effect of levocetirizine. Int J Dermatol. 2005;44:796-8 pubmed
  40. Christophe B, Maleux M, Gillard M, Chatelain P, Peck M, Massingham R. The histamine H(1)-receptor antagonist cetirizine does not interact with bradykinin B(1) or B(2)-receptors in vitro. Inflamm Res. 2004;53 Suppl 1:S81-2 pubmed
  41. Jirapongsananuruk O, Sangacharoenkit P, Pongpreuksa S, Visitsunthorn N, Vichyanond P. Is silent sinusitis a cause of chronic urticaria in children?. Asian Pac J Allergy Immunol. 2009;27:103-6 pubmed
    ..Eighteen patients (78.3%) in the treated group and 15 patients (62.5%) in the control group had CU remission (p = 0.24). These data did not support a causal relationship of sinusitis and CU in children. ..
  42. Li A, Junga H, Shou W, Bryant M, Jiang X, Naidong W. Direct injection of solid-phase extraction eluents onto silica columns for the analysis of polar compounds isoniazid and cetirizine in plasma using hydrophilic interaction chromatography with tandem mass spectrometry. Rapid Commun Mass Spectrom. 2004;18:2343-50 pubmed
    Isoniazid and cetirizine do not retain well on reversed-phase columns due to their high polarity. Silica columns, when operated under hydrophilic interaction conditions, do provide excellent retention of these compounds...
  43. Lauriello M, Muzi P, Di Rienzo L, Di Stanislao C, Tirelli G, Bologna M. A two-year course of specific immunotherapy or of continuous antihistamine treatment reverse eosinophilic inflammation in severe persistent allergic rhinitis. Acta Otorhinolaryngol Ital. 2005;25:284-91 pubmed
    ..enrolled: 12 were randomly assigned to specific immunotherapy (group A), 11 to continuous oral antihistamine (cetirizine) treatment (group B), and 8 to an oral antihistamine (cetirizine) on demand (group C)...
  44. Engin B, Ozdemir M, Balevi A, Mevlitoğlu I. Treatment of chronic urticaria with narrowband ultraviolet B phototherapy: a randomized controlled trial. Acta Derm Venereol. 2008;88:247-51 pubmed publisher
    ..20.7). Statistically significant differences were also noted in VAS between the 2 groups (p < 0.01) at 3 months post-treatment. We conclude that NB-UVB may be an effective complementary treatment for patients with chronic urticaria. ..
  45. Riechelmann H. [Oral second generation antihistamines in allergic rhinitis]. Laryngorhinootologie. 2005;84:30-41 pubmed
    ..Due to their minimal adverse effects and efficient symptom reduction oral second generation antihistamines are particularly useful for the treatment of less severe intermittent forms of nasal allergy. ..
  46. Ren X, Tian Y, Zhang Z, Chen Y, Wu L, Huang J. Determination of cetirizine in human plasma using high performance liquid chromatography coupled with tandem mass spectrometric detection: application to a bioequivalence study. Arzneimittelforschung. 2011;61:287-95 pubmed publisher
    A rapid, sensitive and selective HPLC-MS/ MS method was developed and validated for the quantification of cetirizine dihydrochloride (CAS 83881-51-0) in human plasma using mosapride citrate as internal standard (IS, CAS 112885-42-4)...
  47. Ma M, Feng F, Sheng Y, Cui S, Liu H. Development and evaluation of an efficient HPLC/MS/MS method for the simultaneous determination of pseudoephedrine and cetirizine in human plasma: application to phase-I pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2007;846:105-11 pubmed
    ..method was developed and evaluated to determine simultaneously the concentrations of pseudoephedrine and cetirizine in human plasma...
  48. Shtessel M, Tversky J. Reliability of allergy skin testing. Ann Allergy Asthma Immunol. 2018;120:80-83 pubmed publisher
    ..To determine the differential effect of cetirizine on 2 different concentrations of histamine control solution and 5 common allergens used for percutaneous skin ..
  49. Phan H, Moeller M, Nahata M. Treatment of allergic rhinitis in infants and children: efficacy and safety of second-generation antihistamines and the leukotriene receptor antagonist montelukast. Drugs. 2009;69:2541-76 pubmed publisher
    ..Data on the use of the second-generation antihistamines oral cetirizine, levocetirizine, loratadine, desloratadine and fexofenadine, and the leukotriene receptor antagonist montelukast ..
  50. Biedroł A, Kaciłski M, Skowronek Bała B. Stabbing headache in an 8-year-old girl: primary or drug induced headache?. Pediatrics. 2014;133:e1068-71 pubmed publisher
    ..Six months later, the girl remained headache free. In cases involving differential diagnoses of stabbing headaches, it is important to consider the adverse reactions of the drugs used. ..
  51. Handing K, Shabalin I, Szlachta K, Majorek K, Minor W. Crystal structure of equine serum albumin in complex with cetirizine reveals a novel drug binding site. Mol Immunol. 2016;71:143-151 pubmed publisher
    ..Here, we report the first crystal structure of equine serum albumin (ESA) in complex with antihistamine drug cetirizine at a resolution of 2.1Ã…...
  52. Lindberg L, Santelli J, Desai S. Understanding the Decline in Adolescent Fertility in the United States, 2007-2012. J Adolesc Health. 2016;59:577-583 pubmed publisher
    ..Efforts to further improve access to and use of contraception among adolescents are necessary to ensure they have the means to prevent pregnancy. ..
  53. Mahesh A, Shastri N, Sadanandam M. Development of taste masked fast disintegrating films of levocetirizine dihydrochloride for oral use. Curr Drug Deliv. 2010;7:21-7 pubmed
    ..Results revealed that the organoleptic properties of levocetirizine dihydrochloride were improved by complexation with hydroxy propyl beta-cyclodextrin and the complex could be successfully formulated into a fast disintegrating film. ..