histone deacetylase 2


Summary: A histone deacetylase subtype that is found along with HISTONE DEACETYLASE 1; RETINOBLASTOMA-BINDING PROTEIN 4; and RETINOBLASTOMA-BINDING PROTEIN 7 as core components of histone deacetylase complexes.

Top Publications

  1. Schneider G, Kramer O, Saur D. A ZEB1-HDAC pathway enters the epithelial to mesenchymal transition world in pancreatic cancer. Gut. 2012;61:329-30 pubmed publisher
  2. Kobayashi Y, Bossley C, Gupta A, Akashi K, Tsartsali L, Mercado N, et al. Passive smoking impairs histone deacetylase-2 in children with severe asthma. Chest. 2014;145:305-312 pubmed publisher
    ..This novel mechanism will be a treatment target in children with severe asthma and stresses the need for a smoke-free environment for asthmatic children. ..
  3. Flici H, Schnitzler C, Millane R, Govinden G, Houlihan A, Boomkamp S, et al. An Evolutionarily Conserved SoxB-Hdac2 Crosstalk Regulates Neurogenesis in a Cnidarian. Cell Rep. 2017;18:1395-1409 pubmed publisher
    ..We hypothesize that crosstalk between SoxB transcription factors and Hdac2 is an ancient feature of metazoan neurogenesis and functions to stabilize the correct levels of these multifunctional proteins. ..
  4. Xie R, Yao Y, Tang P, Chen G, Liu X, Yun F, et al. Design, synthesis and biological evaluation of novel hydroxamates and 2-aminobenzamides as potent histone deacetylase inhibitors and antitumor agents. Eur J Med Chem. 2017;134:1-12 pubmed publisher
    ..Furthermore, 12a remarkably induced apoptosis and G2/M phase cell cycle arrest in A549 cancer cells. Those results indicated that compound 12a could be a promising candidate for treatment of cancer. ..
  5. Lin Y, Dong J, Tang Y, Ni H, Zhang Y, Su P, et al. Opening a New Time Window for Treatment of Stroke by Targeting HDAC2. J Neurosci. 2017;37:6712-6728 pubmed publisher
    ..Here we show that ischemia-induced histone deacetylase 2 (HDAC2) upregulation from 5 to 7 d after stroke plays a crucial role...
  6. Kumar P, Gogulamudi V, Periasamy R, Raghavaraju G, Subramanian U, Pandey K. Inhibition of HDAC enhances STAT acetylation, blocks NF-?B, and suppresses the renal inflammation and fibrosis in Npr1 haplotype male mice. Am J Physiol Renal Physiol. 2017;313:F781-F795 pubmed publisher
    ..The current findings will help in developing the molecular therapeutic targets and new treatment strategies for hypertension and renal dysfunction in humans. ..
  7. Ma Y, Berkowitz G. Danger at your door: pathogen signals and programmed cell death in plants. New Phytol. 2011;192:1-3 pubmed publisher
  8. Liu H, Chen S, Yao X, Li Y, Chen C, Liu J, et al. Histone deacetylases 1 and 2 regulate the transcriptional programs of nephron progenitors and renal vesicles. Development. 2018;145: pubmed publisher
    ..We conclude that the epigenetic regulators HDAC1 and HDAC2 control nephrogenesis via interactions with the transcriptional programs of nephron progenitors and renal vesicles. ..
  9. Somanath P, Herndon Klein R, Knoepfler P. CRISPR-mediated HDAC2 disruption identifies two distinct classes of target genes in human cells. PLoS ONE. 2017;12:e0185627 pubmed publisher
    ..Overall, our study defines two classes of HDAC2 targets in human cells, with a dependence of HDAC1 on HDAC2 at one class of targets, and distinguishes unique functions for HDAC2...

More Information


  1. Zhang Z, Lei A, Xu L, Chen L, Chen Y, Zhang X, et al. Similarity in gene-regulatory networks suggests that cancer cells share characteristics of embryonic neural cells. J Biol Chem. 2017;292:12842-12859 pubmed publisher
    ..This observed similarity in regulatory mechanisms suggests that cancer cells might share characteristics of embryonic neural cells. ..
  2. Kumar D, Thakur M. Effect of perinatal exposure to Bisphenol-A on DNA methylation and histone acetylation in cerebral cortex and hippocampus of postnatal male mice. J Toxicol Sci. 2017;42:281-289 pubmed publisher
    ..Altogether, our results demonstrate that the perinatal BPA exposure induces epigenetic changes that possibly underlie the enduring effect of BPA on brain function and behavior. ..
  3. Wang H, Kohashi K, Yoshizumi T, Okumura Y, Tanaka Y, Shimokawa M, et al. Coexpression of SALL4 with HDAC1 and/or HDAC2 is associated with underexpression of PTEN and poor prognosis in patients with hepatocellular carcinoma. Hum Pathol. 2017;64:69-75 pubmed publisher
    ..with the nucleosome remodeling deacetylase complex, which contains histone deacetylase 1 (HDAC1) and histone deacetylase 2 (HDAC2)...
  4. Mehndiratta S, Wang R, Huang H, Su C, Hsu C, Wu Y, et al. 4-Indolyl-N-hydroxyphenylacrylamides as potent HDAC class I and IIB inhibitors in vitro and in vivo. Eur J Med Chem. 2017;134:13-23 pubmed publisher
    ..Therefore, compound 13 could be a suitable lead for further investigation and the development of selective HDAC 2 inhibitors as potent anti-cancer compounds. ..
  5. Streubel G, Fitzpatrick D, Oliviero G, Scelfo A, Moran B, Das S, et al. Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal. EMBO J. 2017;36:2216-2232 pubmed publisher
    ..Taken together, Fam60a is an essential core subunit of a variant Sin3a complex in ES cells that is required to promote rapid proliferation and prevent unscheduled differentiation. ..
  6. Ibi D, de la Fuente Revenga M, Kezunovic N, Muguruza C, Saunders J, Gaitonde S, et al. Antipsychotic-induced Hdac2 transcription via NF-?B leads to synaptic and cognitive side effects. Nat Neurosci. 2017;20:1247-1259 pubmed publisher
    ..Conversely, virally mediated activation of NF-?B signaling decreased cortical synaptic plasticity via HDAC2. Together, these observations may aid in developing therapeutic strategies to improve the outcome of schizophrenia treatment. ..
  7. Hayashi S, Uehara D, Tanimoto K, Mizuno S, Chinen Y, Fukumura S, et al. Comprehensive investigation of CASK mutations and other genetic etiologies in 41 patients with intellectual disability and microcephaly with pontine and cerebellar hypoplasia (MICPCH). PLoS ONE. 2017;12:e0181791 pubmed publisher
  8. Durham B, Grigg R, Wood I. Inhibition of histone deacetylase 1 or 2 reduces induced cytokine expression in microglia through a protein synthesis independent mechanism. J Neurochem. 2017;143:214-224 pubmed publisher
    ..Taken together, this study supports the idea that inhibitors selective towards HDAC1 or HDAC2, may be therapeutically useful for targeting neuroinflammation in brain injuries and neurodegenerative disease. ..
  9. Park H, Kim J, Jung Y, Park C. Racial Differences in the Extracellular Matrix and Histone Acetylation of the Lamina Cribrosa and Peripapillary Sclera. Invest Ophthalmol Vis Sci. 2017;58:4143-4154 pubmed publisher
    ..Further study to reveal the association with these findings to the pathogenesis of glaucoma in Korean eyes is needed. ..
  10. Moruno Manchon J, Uzor N, Blasco Conesa M, Mannuru S, Putluri N, Furr Stimming E, et al. Inhibiting sphingosine kinase 2 mitigates mutant Huntingtin-induced neurodegeneration in neuron models of Huntington disease. Hum Mol Genet. 2017;26:1305-1317 pubmed publisher
    ..Our results identify a novel regulator of mutant huntingtin-mediated neurotoxicity and provide a new target for developing therapies for HD. ..
  11. Li H, Richardson W. Genetics meets epigenetics: HDACs and Wnt signaling in myelin development and regeneration. Nat Neurosci. 2009;12:815-7 pubmed publisher
  12. Mao Q, Zhang W, Zhao K, Cao B, Yuan H, Wei L, et al. MicroRNA-455 suppresses the oncogenic function of HDAC2 in human colorectal cancer. Braz J Med Biol Res. 2017;50:e6103 pubmed publisher
    Colorectal cancer (CRC) is the fourth leading cause of cancer-induced mortality. Histone deacetylase 2 (HDAC2) is involved in prognosis and therapy of CRC. This study aimed to explore novel therapeutic targets for CRC...