rotenone

Summary

Summary: A botanical insecticide that is an inhibitor of mitochondrial electron transport.

Top Publications

  1. Dadakhujaev S, Noh H, Jung E, Cha J, Baek S, Ha J, et al. Autophagy protects the rotenone-induced cell death in alpha-synuclein overexpressing SH-SY5Y cells. Neurosci Lett. 2010;472:47-52 pubmed publisher
    ..LC3-II protein, a critical marker for autophagy, was produced in an autophagy-dependent manner. The rotenone-induced cell death was interrupted by autophagy stimulation...
  2. Bahadorani S, Cho J, Lo T, Contreras H, Lawal H, Krantz D, et al. Neuronal expression of a single-subunit yeast NADH-ubiquinone oxidoreductase (Ndi1) extends Drosophila lifespan. Aging Cell. 2010;9:191-202 pubmed publisher
    ..These findings are consistent with the idea that enhanced respiratory chain activity in neuronal tissue can prolong fly lifespan. ..
  3. Mulcahy P, Walsh S, Paucard A, Rea K, Dowd E. Characterisation of a novel model of Parkinson's disease by intra-striatal infusion of the pesticide rotenone. Neuroscience. 2011;181:234-42 pubmed publisher
    ..the most promising models of Parkinson's disease to have emerged in recent years is one in which the pesticide, rotenone, is administered systemically to laboratory rats...
  4. Maldonado E, Patnaik J, Mullins M, Lemasters J. Free tubulin modulates mitochondrial membrane potential in cancer cells. Cancer Res. 2010;70:10192-201 pubmed publisher
    ..Microtubule destabilizers, rotenone, colchicine, and nocodazole, and the microtubule stabilizer paclitaxel increased and decreased cellular free ..
  5. Zaitone S, Abo Elmatty D, Shaalan A. Acetyl-L-carnitine and ?-lipoic acid affect rotenone-induced damage in nigral dopaminergic neurons of rat brain, implication for Parkinson's disease therapy. Pharmacol Biochem Behav. 2012;100:347-60 pubmed publisher
    ..to investigate the protective role of two bioenergetic antioxidants, acetyl-L-carnitine and ?-lipoic acid, in rotenone-parkinsonian rats. Ninety six male rats were divided into five groups...
  6. Condello S, Calabrò E, Caccamo D, Currò M, Ferlazzo N, Satriano J, et al. Protective effects of agmatine in rotenone-induced damage of human SH-SY5Y neuroblastoma cells: fourier transform infrared spectroscopy analysis in a model of Parkinson's disease. Amino Acids. 2012;42:775-81 pubmed publisher
    ..In this report, we utilize FTIR spectroscopy to characterize the changes in rotenone-induced damage in neuronal-like differentiated SH-SY5Y neuroblastoma cells in the presence or absence of agmatine...
  7. Choi W, Palmiter R, Xia Z. Loss of mitochondrial complex I activity potentiates dopamine neuron death induced by microtubule dysfunction in a Parkinson's disease model. J Cell Biol. 2011;192:873-82 pubmed publisher
    ..In contrast, rotenone, another complex I inhibitor, causes selective toxicity to dopamine neurons, and Ndufs4 inactivation potentiates ..
  8. Weetman J, Wong M, Sharry S, Rcom H cheo Gauthier A, Gai W, Meedeniya A, et al. Increased SUMO-1 expression in the unilateral rotenone-lesioned mouse model of Parkinson's disease. Neurosci Lett. 2013;544:119-24 pubmed publisher
    ..We investigated a unilateral rotenone-lesioned mouse PD model...
  9. Zhang S, Liang R, Zhou F, Huang X, Ding J, Hu G. Reversal of rotenone-induced dysfunction of astrocytic connexin43 by opening mitochondrial ATP-sensitive potassium channels. Cell Mol Neurobiol. 2011;31:111-7 pubmed publisher
    ..However, little is known about the role of Cx43 in Parkinson's disease (PD). In this article, we report that rotenone, a classic neurotoxin for PD, could inhibit expression of astrocytic Cx43 and gap junction permeability...

Scientific Experts

More Information

Publications62

  1. Erbaş O, Oltulu F, Taskiran D. Amelioration of rotenone-induced dopaminergic cell death in the striatum by oxytocin treatment. Peptides. 2012;38:312-7 pubmed publisher
    ..The present study was undertaken to investigate the neuroprotective effects of oxytocin (OT) on rotenone-induced PD in rats...
  2. Fan L, Tien L, Lin R, Simpson K, Rhodes P, Cai Z. Neonatal exposure to lipopolysaccharide enhances vulnerability of nigrostriatal dopaminergic neurons to rotenone neurotoxicity in later life. Neurobiol Dis. 2011;44:304-16 pubmed publisher
    ..By P70, when LPS-induced behavioral deficits were spontaneously recovered, animals were challenged with rotenone, a commonly used pesticide, through subcutaneous mini-pump infusion at a dose of 1.25 mg/kg per day for 14 days...
  3. Luo J, Zhang Z, Yu S, Zhao B, Zhao C, Wang X, et al. [Rotenone-induced changes of cysteinyl leukotriene receptor 1 expression in BV2 microglial cells]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2011;40:131-8 pubmed
    ..1 (CysLT(1)) and to investigate the changes of CysLT(1) receptor expression in BV2 microglial cells after rotenone treatment. Rabbits were immunized with KLH-coupled CysLT(1) peptide to prepare the pAb...
  4. Sonia Angeline M, Chaterjee P, Anand K, Ambasta R, Kumar P. Rotenone-induced parkinsonism elicits behavioral impairments and differential expression of parkin, heat shock proteins and caspases in the rat. Neuroscience. 2012;220:291-301 pubmed publisher
    b>Rotenone is a pesticide that inhibits mitochondrial complex I activity, thus creating an environment of oxidative stress in the cell...
  5. Nesti C, Pardini C, Barachini S, D Alessandro D, Siciliano G, Murri L, et al. Human dental pulp stem cells protect mouse dopaminergic neurons against MPP+ or rotenone. Brain Res. 2011;1367:94-102 pubmed publisher
    ..5, 5, and 10 ?M) and rotenone (0.25, 0...
  6. Gao F, Chen D, Hu Q, Wang G. Rotenone directly induces BV2 cell activation via the p38 MAPK pathway. PLoS ONE. 2013;8:e72046 pubmed publisher
    ..In the present study, we found that rotenone, a mitochondrial complex I inhibitor, could directly activate microglia via the nuclear factor kappa B (NF-?B) ..
  7. Corona J, Gimenez Cassina A, Lim F, Diaz Nido J. Hexokinase II gene transfer protects against neurodegeneration in the rotenone and MPTP mouse models of Parkinson's disease. J Neurosci Res. 2010;88:1943-50 pubmed publisher
    ..b>Rotenone or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) inhibit the mitochondrial complex I and they cause the ..
  8. Lee H, Lee J, Jung K, Hong S. Deguelin promotes apoptosis and inhibits angiogenesis of gastric cancer. Oncol Rep. 2010;24:957-63 pubmed
    ..Deguelin may be a potential agent in inhibiting the progression of gastric cancer by virtue of its activity on these crucial cell characteristics. ..
  9. Deng Y, Shi J, Liu J, Qu Q. Celastrol protects human neuroblastoma SH-SY5Y cells from rotenone-induced injury through induction of autophagy. Neurochem Int. 2013;63:1-9 pubmed publisher
    ..We tested the protective effect of celastrol on rotenone-induced injury and investigated the underlying mechanism using human neuroblastoma SH-SY5Y cells...
  10. Greenamyre J, Cannon J, Drolet R, Mastroberardino P. Lessons from the rotenone model of Parkinson's disease. Trends Pharmacol Sci. 2010;31:141-2; author reply 142-3 pubmed publisher
  11. Kaur H, Chauhan S, Sandhir R. Protective effect of lycopene on oxidative stress and cognitive decline in rotenone induced model of Parkinson's disease. Neurochem Res. 2011;36:1435-43 pubmed publisher
    ..to investigate the neuroprotective potential of lycopene on oxidative stress and neurobehavioral abnormalities in rotenone induced PD. Rats were treated with rotenone (3 mg/kg body weight, intraperitoneally) for 30 days...
  12. Esteve Rudd J, Fernández Sánchez L, Lax P, de Juan E, Martín Nieto J, Cuenca N. Rotenone induces degeneration of photoreceptors and impairs the dopaminergic system in the rat retina. Neurobiol Dis. 2011;44:102-15 pubmed publisher
    b>Rotenone is a widely used pesticide and a potent inhibitor of mitochondrial complex I (NADH-quinone reductase) that elicits the degeneration of dopaminergic neurons and thereby the appearance of a parkinsonian syndrome...
  13. Choi W, Abel G, Klintworth H, Flavell R, Xia Z. JNK3 mediates paraquat- and rotenone-induced dopaminergic neuron death. J Neuropathol Exp Neurol. 2010;69:511-20 pubmed publisher
    ..kinase 3 (JNK3), a neural-specific JNK isoform, in dopaminergic neuron death induced by the pesticides rotenone and paraquat. The role of JNK3 was evaluated using RNA silencing and gene deletion to block JNK3 signaling...
  14. Inden M, Kitamura Y, Abe M, Tamaki A, Takata K, Taniguchi T. Parkinsonian rotenone mouse model: reevaluation of long-term administration of rotenone in C57BL/6 mice. Biol Pharm Bull. 2011;34:92-6 pubmed
    Chronic systemic exposure of Lewis rats to rotenone produced many features of Parkinson's disease (PD), including nigrostriatal dopamine (DA) neurodegeneration and the formation of cytoplasmic inclusions in nigral DA neurons...
  15. Pan Montojo F, Schwarz M, Winkler C, Arnhold M, O Sullivan G, Pal A, et al. Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice. Sci Rep. 2012;2:898 pubmed publisher
    ..Moreover, our results show that an environmental toxin (i.e. rotenone) promotes the release of alpha-synuclein by enteric neurons and that released enteric alpha-synuclein is up-taken ..
  16. Hosamani R, Ramesh S, Muralidhara -. Attenuation of rotenone-induced mitochondrial oxidative damage and neurotoxicty in Drosophila melanogaster supplemented with creatine. Neurochem Res. 2010;35:1402-12 pubmed publisher
    ..This study investigated the neuroprotective effects of Cr against rotenone induced oxidative stress, mortality and neurotoxicty in Drosophila melanogaster...
  17. Wu Y, Li X, Zhu J, Xie W, Le W, Fan Z, et al. Resveratrol-activated AMPK/SIRT1/autophagy in cellular models of Parkinson's disease. Neurosignals. 2011;19:163-74 pubmed publisher
    ..Our results showed that resveratrol protected against rotenone-induced apoptosis in SH-SY5Y cells and enhanced degradation of ?-synucleins in ?-synuclein-expressing PC12 cell ..
  18. Gao H, Yang W, Qi Z, Lu L, Duan C, Zhao C, et al. DJ-1 protects dopaminergic neurons against rotenone-induced apoptosis by enhancing ERK-dependent mitophagy. J Mol Biol. 2012;423:232-48 pubmed publisher
    ..Cultured DA cells (MN9D) overexpressing DJ-1 were treated with the mitochondrial complex I inhibitor, rotenone. In addition, rotenone was injected into the left substantia nigra of rats 4weeks after injection with a DJ-1 ..
  19. Sanders L, Timothy Greenamyre J. Oxidative damage to macromolecules in human Parkinson disease and the rotenone model. Free Radic Biol Med. 2013;62:111-120 pubmed publisher
    ..substantial evidence for oxidative stress both in human PD patients and in animal models of PD, especially using rotenone, a complex I inhibitor...
  20. Wu F, Wang Z, Gu J, Ge J, Liang Z, Qin Z. p38(MAPK)/p53-Mediated Bax induction contributes to neurons degeneration in rotenone-induced cellular and rat models of Parkinson's disease. Neurochem Int. 2013;63:133-40 pubmed publisher
    b>Rotenone is an environmental neurotoxin that induces degeneration of dopaminergic (DA) neurons in substantia nigra pars compacta (SNpc), which ultimately results in parkinsonism, but the molecular mechanisms of selective degeneration of ..
  21. Parameshwaran K, Irwin M, Steliou K, Pinkert C. Protection by an antioxidant of rotenone-induced neuromotor decline, reactive oxygen species generation and cellular stress in mouse brain. Pharmacol Biochem Behav. 2012;101:487-92 pubmed publisher
    Exposure to environmental toxins, including rotenone, results in central nervous system and systemic toxicity. Rotenone is a widely used pesticide and a mitochondrial complex I (CI) inhibitor...
  22. Radad K, Moldzio R, Rausch W. Minocycline protects dopaminergic neurons against long-term rotenone toxicity. Can J Neurol Sci. 2010;37:81-5 pubmed
    ..To investigate the neuroprotective effects of minocycline against long-term rotenone toxicity in primary dopaminergic cell cultures...
  23. Cabeza Arvelaiz Y, Schiestl R. Transcriptome analysis of a rotenone model of parkinsonism reveals complex I-tied and -untied toxicity mechanisms common to neurodegenerative diseases. PLoS ONE. 2012;7:e44700 pubmed publisher
    The pesticide rotenone, a neurotoxin that inhibits the mitochondrial complex I, and destabilizes microtubules (MT) has been linked to Parkinson disease (PD) etiology and is often used to model this neurodegenerative disease (ND)...
  24. Peckmann K, von Willert D, Martin C, Herppich W. Mitochondrial respiration in ME-CAM, PEPCK-CAM, and C? succulents: comparative operation of the cytochrome, alternative, and rotenone-resistant pathways. J Exp Bot. 2012;63:2909-19 pubmed publisher
    ..of mitochondria, as well as the activity of CAM-linked mitochondrial enzymes, and of the alternative and the rotenone-resistant pathways of substrate oxidation were compared...
  25. Kamalden T, Ji D, Osborne N. Rotenone-induced death of RGC-5 cells is caspase independent, involves the JNK and p38 pathways and is attenuated by specific green tea flavonoids. Neurochem Res. 2012;37:1091-101 pubmed publisher
    The aim of the present studies was to characterise cell death following inhibition of mitochondrial complex I with rotenone in a transformed cell line (RGC-5 cells) and to examine the neuroprotective properties of the flavonoids genistein,..
  26. Wu Y, Li X, Xie W, Jankovic J, Le W, Pan T. Neuroprotection of deferoxamine on rotenone-induced injury via accumulation of HIF-1 alpha and induction of autophagy in SH-SY5Y cells. Neurochem Int. 2010;57:198-205 pubmed publisher
    ..In this study, we showed that the protein level of HIF-1 alpha was decreased in rotenone or MPP(+)-treated SH-SY5Y cell models of Parkinson's disease...
  27. Mader B, Pivtoraiko V, Flippo H, Klocke B, Roth K, Mangieri L, et al. Rotenone inhibits autophagic flux prior to inducing cell death. ACS Chem Neurosci. 2012;3:1063-72 pubmed publisher
    b>Rotenone, which selectively inhibits mitochondrial complex I, induces oxidative stress, ?-synuclein accumulation, and dopaminergic neuron death, principal pathological features of Parkinson's disease...
  28. Chang C, Song M, Jeon S, Yoon H, Lee D, Kim I, et al. Dual functionality of myeloperoxidase in rotenone-exposed brain-resident immune cells. Am J Pathol. 2011;179:964-79 pubmed publisher
    b>Rotenone exposure has emerged as an environmental risk factor for inflammation-associated neurodegenerative diseases. However, the underlying mechanisms responsible for the harmful effects of rotenone in the brain remain poorly understood...
  29. Gonçalves A, Videira A, Máximo V, Soares P. Synergistic growth inhibition of cancer cells harboring the RET/PTC1 oncogene by staurosporine and rotenone involves enhanced cell death. J Biosci. 2011;36:639-48 pubmed
    ..The bacterial alkaloid staurosporine and the plant extract rotenone are death-inducing drugs that have an inhibitory synergistic effect on the growth of TPC-1 cells...
  30. Wu Y, Johnson S. Dopamine oxidation facilitates rotenone-dependent potentiation of N-methyl-D-aspartate currents in rat substantia nigra dopamine neurons. Neuroscience. 2011;195:138-44 pubmed publisher
    b>Rotenone is a mitochondrial poison that causes dopamine cell death and is used as a model of Parkinson's disease in rodents...
  31. Xu Q, Vu H, Liu L, Wang T, Schaefer W. Metabolic profiles show specific mitochondrial toxicities in vitro in myotube cells. J Biomol NMR. 2011;49:207-19 pubmed publisher
    ..the application of quantitative NMR metabolomics to in vitro myotube cells treated with mitochondrial toxicants, rotenone and antimycin A...
  32. Navarro A, Bandez M, Gomez C, Repetto M, Boveris A. Effects of rotenone and pyridaben on complex I electron transfer and on mitochondrial nitric oxide synthase functional activity. J Bioenerg Biomembr. 2010;42:405-12 pubmed publisher
    b>Rotenone and pyridaben were tested on activities and properties of rat brain mitochondria determining Ki (inhibitor concentration at half maximal inhibition) and Imax (% of inhibition at maximal inhibitor concentration)...
  33. Haefeli R, Erb M, Gemperli A, Robay D, Courdier Fruh I, Anklin C, et al. NQO1-dependent redox cycling of idebenone: effects on cellular redox potential and energy levels. PLoS ONE. 2011;6:e17963 pubmed publisher
  34. Chou A, Li S, Fitzmaurice A, Bronstein J. Mechanisms of rotenone-induced proteasome inhibition. Neurotoxicology. 2010;31:367-72 pubmed publisher
    ..It has been shown that pesticides, including the complex I inhibitor rotenone, cause proteasome inhibition but the mechanism of rotenone-induced proteasome dysfunction remains largely unknown...
  35. Gonçalves A, Máximo V, Lima J, Singh K, Soares P, Videira A. Involvement of p53 in cell death following cell cycle arrest and mitotic catastrophe induced by rotenone. Biochim Biophys Acta. 2011;1813:492-9 pubmed publisher
    In order to investigate the cell death-inducing effects of rotenone, a plant extract commonly used as a mitochondrial complex I inhibitor, we studied cancer cell lines with different genetic backgrounds...
  36. Castro A, Lemos C, Falcão A, Fernandes A, Glass N, Videira A. Rotenone enhances the antifungal properties of staurosporine. Eukaryot Cell. 2010;9:906-14 pubmed publisher
    ..Following this finding, we determined that the complex I-specific inhibitor rotenone used in combination with staurosporine results in a synergistic and specific antifungal activity, likely through ..
  37. Hongo H, Kihara T, Kume T, Izumi Y, Niidome T, Sugimoto H, et al. Glycogen synthase kinase-3? activation mediates rotenone-induced cytotoxicity with the involvement of microtubule destabilization. Biochem Biophys Res Commun. 2012;426:94-9 pubmed publisher
    b>Rotenone, a mitochondrial complex I inhibitor, has been used to generate animal and cell culture models of Parkinson's disease. Recent studies suggest that microtubule destabilization causes selective dopaminergic neuronal loss...
  38. Siddiqui M, Kashyap M, Khanna V, Yadav S, Al Khedhairy A, Musarrat J, et al. Association of dopamine DA-D2 receptor in rotenone-induced cytotoxicity in PC12 cells. Toxicol Ind Health. 2010;26:533-42 pubmed publisher
    The investigations were aimed to study the possible association of dopamine DA-D(2) receptor in rotenone-induced cytotoxicity in PC12 cells, one among the most studied cell line in neurotoxicity studies...
  39. Tamilselvam K, Braidy N, Manivasagam T, Essa M, Prasad N, Karthikeyan S, et al. Neuroprotective effects of hesperidin, a plant flavanone, on rotenone-induced oxidative stress and apoptosis in a cellular model for Parkinson's disease. Oxid Med Cell Longev. 2013;2013:102741 pubmed publisher
    b>Rotenone a widely used pesticide that inhibits mitochondrial complex I has been used to investigate the pathobiology of PD both in vitro and in vivo...
  40. Goodwin W, McCabe D, Sauter E, Reese E, Walter M, Buckwalter J, et al. Rotenone prevents impact-induced chondrocyte death. J Orthop Res. 2010;28:1057-63 pubmed publisher
    ..Most positive cells were found within and near areas contacted directly by the impact platen. Rotenone, an electron transport chain inhibitor, was used to test the hypothesis that mitochondria contribute to ..
  41. Yuan Y, Sun J, Wu M, Hu J, Peng S, Chen N. Rotenone could activate microglia through NF?B associated pathway. Neurochem Res. 2013;38:1553-60 pubmed publisher
    ..Results showed that rotenone could induce tumor neurosis factor ? (TNF?) and interleukin 1? (IL-1?) release from BV-2 cells, enhance TNF? and ..
  42. Filomeni G, Graziani I, De Zio D, Dini L, Centonze D, Rotilio G, et al. Neuroprotection of kaempferol by autophagy in models of rotenone-mediated acute toxicity: possible implications for Parkinson's disease. Neurobiol Aging. 2012;33:767-85 pubmed publisher
    This study aims to elucidate the processes underlying neuroprotection of kaempferol in models of rotenone-induced acute toxicity...
  43. Inden M, Takata K, Nishimura K, Kitamura Y, Ashihara E, Yoshimoto K, et al. Therapeutic effects of human mesenchymal and hematopoietic stem cells on rotenone-treated parkinsonian mice. J Neurosci Res. 2013;91:62-72 pubmed publisher
    ..cells--mesenchymal stem cells (MSCs), bone marrow CD34(+) cells (BM), and cord blood CD34(+) cells (CB)--using rotenone-treated NOD/SCID mice...
  44. Sapkota K, Kim S, Park S, Kim S. Detoxified extract of Rhus verniciflua stokes inhibits rotenone-induced apoptosis in human dopaminergic cells, SH-SY5Y. Cell Mol Neurobiol. 2011;31:213-23 pubmed publisher
    ..Environmental neurotoxins such as rotenone, a specific inhibitor of complex I provide models of Parkinson's disease (PD) both in vivo and in vitro...
  45. Antkiewicz Michaluk L, Wasik A, Romańska I, Bojarski A, Michaluk J. Both stereoselective (R)- and (S)-1-Methyl-1,2,3,4-tetrahydroisoquinoline enantiomers protect striatal terminals against rotenone-induced suppression of dopamine release. Neurotox Res. 2011;20:134-49 pubmed publisher
    ..p.) on rotenone-induced (3 mg/kg s.c.) behavioral and neurochemical changes in the rat...
  46. Swarnkar S, Goswami P, Kamat P, Gupta S, Patro I, Singh S, et al. Rotenone-induced apoptosis and role of calcium: a study on Neuro-2a cells. Arch Toxicol. 2012;86:1387-97 pubmed publisher
    b>Rotenone causes cytotoxicity in astrocytic cell culture by glial activation, which is linked to free radical generation...
  47. Rathinam M, Watts L, Narasimhan M, Riar A, Mahimainathan L, Henderson G. Astrocyte mediated protection of fetal cerebral cortical neurons from rotenone and paraquat. Environ Toxicol Pharmacol. 2012;33:353-60 pubmed publisher
    ..that astrocyte-mediated control of neuronal glutathione (GSH) is a potent factor in neuroprotection against rotenone and paraquat. In neurons, rotenone (0.025-1 ?M) for 4 and 24 h decreased viability as did paraquat (2-100 ?M)...
  48. Chaves R, Melo T, Martins S, Ferrari M. Protein aggregation containing ?-amyloid, ?-synuclein and hyperphosphorylated ? in cultured cells of hippocampus, substantia nigra and locus coeruleus after rotenone exposure. BMC Neurosci. 2010;11:144 pubmed publisher
    ..5, 1, 10 and 25 nM of rotenone, which is an agricultural pesticide, for 48 hours...
  49. George S, Mok S, Nurjono M, Ayton S, Finkelstein D, Masters C, et al. ?-Synuclein transgenic mice reveal compensatory increases in Parkinson's disease-associated proteins DJ-1 and parkin and have enhanced ?-synuclein and PINK1 levels after rotenone treatment. J Mol Neurosci. 2010;42:243-54 pubmed publisher
    ..Since treatment of rodents with the pesticide rotenone can reproduce nigrostriatal cell loss and other features of PD, we aimed to test chronic oral administration of ..
  50. Bai Q, He J, Qiu J, Wang Y, Wang S, Xiu Y, et al. Rotenone induces KATP channel opening in PC12 cells in association with the expression of tyrosine hydroxylase. Oncol Rep. 2012;28:1376-84 pubmed publisher
    ..KATP) channels in PC12 cells play a pivotal role in protection against the neurotoxic effect of rotenone. However, it remains unclear why rotenone seems to preferentially affect activation of KATP ..
  51. Dranka B, Zielonka J, Kanthasamy A, Kalyanaraman B. Alterations in bioenergetic function induced by Parkinson's disease mimetic compounds: lack of correlation with superoxide generation. J Neurochem. 2012;122:941-51 pubmed publisher
    ..Similar results were found using rotenone as a mitochondrial inhibitor, or 6-hydroxydopamine (6-OHDA) as a mechanistically distinct PD neurotoxicant, but ..
  52. Jayaraj R, Tamilselvam K, Manivasagam T, Elangovan N. Neuroprotective effect of CNB-001, a novel pyrazole derivative of curcumin on biochemical and apoptotic markers against rotenone-induced SK-N-SH cellular model of Parkinson's disease. J Mol Neurosci. 2013;51:863-70 pubmed publisher
    ..In this present study, we investigated the protective effect of CNB-001, a pyrazole derivative of curcumin on rotenone-induced toxicity and its possible mechanisms in neuroblastoma SK-N-SH cells...
  53. Ulusoy G, Celik T, Kayir H, Gursoy M, Isik A, Uzbay T. Effects of pioglitazone and retinoic acid in a rotenone model of Parkinson's disease. Brain Res Bull. 2011;85:380-4 pubmed publisher
    ..was to investigate the effects of pioglitazone and retinoic acid, antioxidant and neuroprotective agents, on rotenone-induced model of PD in rats. Adult male Wistar rats (260-373 g) were subjects. Rotenone (2...