berberine

Summary

Summary: An alkaloid from Hydrastis canadensis L., Berberidaceae. It is also found in many other plants. It is relatively toxic parenterally, but has been used orally for various parasitic and fungal infections and as antidiarrheal.

Top Publications

  1. Pierpaoli E, Arcamone A, Buzzetti F, Lombardi P, Salvatore C, Provinciali M. Antitumor effect of novel berberine derivatives in breast cancer cells. Biofactors. 2013;39:672-9 pubmed publisher
    ..In this study, we investigated the efficacy of some new synthetic derivatives of berberine, a phytochemical isolated from Barberry and other plants, to induce growth arrest of HER-2/neu overexpressing SK-..
  2. Wang J, Liu Q, Yang Q. Radiosensitization effects of berberine on human breast cancer cells. Int J Mol Med. 2012;30:1166-72 pubmed publisher
    b>Berberine, an isoquinoline derivative alkaloid, has recently been shown to have antitumor activity. The present study aimed to investigate the effects of the concomitant administration of berberine and radiation on breast cancer...
  3. Bandyopadhyay S, Patra P, Mahanti A, Mondal D, Dandapat P, Bandyopadhyay S, et al. Potential antibacterial activity of berberine against multi drug resistant enterovirulent Escherichia coli isolated from yaks (Poephagus grunniens) with haemorrhagic diarrhoea. Asian Pac J Trop Med. 2013;6:315-9 pubmed publisher
    To evaluate the antimicrobial efficacy of berberine, a plant alkaloid. Five multi-drug resistant (MDR) STEC/EPEC and five MDR ETEC isolates from yaks with haemorrhagic diarrhoea were selected for the study...
  4. Xue M, Yang M, Zhang W, Li X, Gao D, Ou Z, et al. Characterization, pharmacokinetics, and hypoglycemic effect of berberine loaded solid lipid nanoparticles. Int J Nanomedicine. 2013;8:4677-87 pubmed publisher
    The high aqueous solubility, poor permeability, and absorption of berberine (BBR) result in its low plasma level after oral administration, which greatly limits its clinical application...
  5. Chang W, Zhang M, Li J, Meng Z, Wei S, Du H, et al. Berberine improves insulin resistance in cardiomyocytes via activation of 5'-adenosine monophosphate-activated protein kinase. Metabolism. 2013;62:1159-67 pubmed publisher
    Insulin resistance plays an important role in the pathogenesis of diabetic cardiomyopathy. Berberine (BBR) is a plant alkaloid which promotes hypoglycemia via increasing insulin sensitivity in peripheral tissues...
  6. Shan Y, Zhu Y, Pang J, Wang Y, Song D, Kong W, et al. Tetrandrine potentiates the hypoglycemic efficacy of berberine by inhibiting P-glycoprotein function. Biol Pharm Bull. 2013;36:1562-9 pubmed
    This study was designed to improve the absorption and hypoglycemic efficacy of berberine (BBR), which is a substrate of P-glycoprotein (P-gp), by combination with a P-gp inhibitor tetrandrine (Tet)...
  7. Li X, Hu Y, Wang H, Yu B, Yue H. Molecular spectroscopy evidence of berberine binding to DNA: comparative binding and thermodynamic profile of intercalation. Biomacromolecules. 2012;13:873-80 pubmed publisher
    b>Berberine (BH) is an important traditional medicinal herb endowed with diverse pharmacological and biological activities...
  8. Xiao H, Sun Z, Zhang H, Zhang D. Berberine inhibits dyslipidemia in C57BL/6 mice with lipopolysaccharide induced inflammation. Pharmacol Rep. 2012;64:889-95 pubmed
    ..Here we investigated the effect of berberine, natural plant extracts, on PCSK9-LDLR pathway in C57BL/6 mice with lipopolysaccharide (LPS) induced ..
  9. Bazzicalupi C, Ferraroni M, Bilia A, Scheggi F, Gratteri P. The crystal structure of human telomeric DNA complexed with berberine: an interesting case of stacked ligand to G-tetrad ratio higher than 1:1. Nucleic Acids Res. 2013;41:632-8 pubmed publisher
    The first crystal structure of human telomeric DNA in complex with the natural alkaloid berberine, produced by different plant families and used in folk medicine for millennia, was solved by X-ray diffraction method...

More Information

Publications62

  1. Chen X, Di Y, Zhang J, Zhou Z, Li C, Zhou S. Interaction of herbal compounds with biological targets: a case study with berberine. ScientificWorldJournal. 2012;2012:708292 pubmed publisher
    b>Berberine is one of the main alkaloids found in the Chinese herb Huang lian (Rhizoma Coptidis), which has been reported to have multiple pharmacological activities...
  2. Hu H, Li K, Wang X, Liu Y, Lu Z, Dong R, et al. Set9, NF-?B, and microRNA-21 mediate berberine-induced apoptosis of human multiple myeloma cells. Acta Pharmacol Sin. 2013;34:157-66 pubmed publisher
    To investigate the mechanisms by which berberine suppressed the proliferation of human multiple myeloma cells.
  3. Hong T, Yang Z, Lv C, Zhang Y. Suppressive effect of berberine on experimental dextran sulfate sodium-induced colitis. Immunopharmacol Immunotoxicol. 2012;34:391-7 pubmed publisher
    The anti-inflammatory effect of berberine was evaluated in murine model of acute experimental colitis induced by dextran sulfate sodium (DSS)...
  4. Wu F, Shao Y, Ma K, Cui Q, Liu G, Xu S. Simultaneous fluorescence light-up and selective multicolor nucleobase recognition based on sequence-dependent strong binding of berberine to DNA abasic site. Org Biomol Chem. 2012;10:3300-7 pubmed publisher
    ..Herein, an abasic site (AP site) in a DNA duplex was employed as a binding field for berberine, one of isoquinoline alkaloids...
  5. Lo C, Hsu L, Chen M, Lin Y, Chen L, Kuo C, et al. Synthesis and anticancer activity of a novel series of 9-O-substituted berberine derivatives: a lipophilic substitute role. Bioorg Med Chem Lett. 2013;23:305-9 pubmed publisher
    To alter its hydrophobicity, a series of compounds bearing 9-O-alkyl- or 9-O-terpenyl- substituted berberine were synthesized and evaluated for anticancer activity against human cancer HepG2 and HT29 cell lines...
  6. Marverti G, Ligabue A, Lombardi P, Ferrari S, Monti M, Frassineti C, et al. Modulation of the expression of folate cycle enzymes and polyamine metabolism by berberine in cisplatin-sensitive and -resistant human ovarian cancer cells. Int J Oncol. 2013;43:1269-80 pubmed publisher
    b>Berberine is a natural isoquinoline alkaloid with significant antitumor activity against many types of cancer cells, including ovarian tumors...
  7. Zhang L, Quan W, Wang B, Shen B, Zhang T, Kang Y. Berberine inhibits HEp-2 cell invasion induced by Chlamydophila pneumoniae infection. J Microbiol. 2011;49:834-40 pubmed publisher
    This study investigated the inhibitory effects of berberine on Chlamydophila (Chlamydia) pneumoniae infection-induced HEp-2 cell invasion and explored the possible mechanisms involved in this process. C...
  8. Huang Z, Zeng Y, Lan P, Sun P, Chen W. Advances in structural modifications and biological activities of berberine: an active compound in traditional Chinese medicine. Mini Rev Med Chem. 2011;11:1122-9 pubmed
    b>Berberine is an isoquinoline alkaloid isolated from Chinese herbs such as Coptidis Rhizome...
  9. Chen W, Miao Y, Fan D, Yang S, Lin X, Meng L, et al. Bioavailability study of berberine and the enhancing effects of TPGS on intestinal absorption in rats. AAPS PharmSciTech. 2011;12:705-11 pubmed publisher
    b>Berberine chloride (BBR) is a natural isoquinoline alkaloid extracted from medicinal herbs. It has been reported that the intestinal absorption of BBR is very low...
  10. Shin K, Choi H, Zhao T, Suh K, Kwon I, Choi S, et al. Neurotoxic effects of berberine on long-term L-DOPA administration in 6-hydroxydopamine-lesioned rat model of Parkinson's disease. Arch Pharm Res. 2013;36:759-67 pubmed publisher
    The effects of berberine on long-term administration of L-DOPA in 6-hydroxydopamine (6-OHDA)-lesioned rat model of Parkinson's disease (PD) were investigated...
  11. Yan F, Wang L, Shi Y, Cao H, Liu L, Washington M, et al. Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice. Am J Physiol Gastrointest Liver Physiol. 2012;302:G504-14 pubmed publisher
    ..A major challenge for IBD research is to develop new strategies for treating this disease. Berberine, an alkaloid derived from plants, is an alternative medicine for treating bacterial diarrhea and intestinal ..
  12. Wang L, Liu L, Shi Y, Cao H, Chaturvedi R, Calcutt M, et al. Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor. PLoS ONE. 2012;7:e36418 pubmed publisher
    b>Berberine, an isoquinoline alkaloid derived from plants, is a traditional medicine for treating bacterial diarrhea and intestinal parasite infections...
  13. Xing L, Zhang L, Liu T, Hua Y, Zheng P, Ji G. Berberine reducing insulin resistance by up-regulating IRS-2 mRNA expression in nonalcoholic fatty liver disease (NAFLD) rat liver. Eur J Pharmacol. 2011;668:467-71 pubmed publisher
    This study was performed to investigate the molecular mechanism and the therapeutic effect of berberine on nonalcoholic fatty liver disease (NAFLD)...
  14. Zhang M, Lv X, Li J, Meng Z, Wang Q, Chang W, et al. Sodium caprate augments the hypoglycemic effect of berberine via AMPK in inhibiting hepatic gluconeogenesis. Mol Cell Endocrinol. 2012;363:122-30 pubmed publisher
    b>Berberine (BER), a natural product and active ingredient of genera Berberis and Coptis, has been demonstrated to possess anti-diabetic activities. However, the poor bioavailability of this agent greatly limits its clinical application...
  15. Chen W, Fan D, Meng L, Miao Y, Yang S, Weng Y, et al. Enhancing effects of chitosan and chitosan hydrochloride on intestinal absorption of berberine in rats. Drug Dev Ind Pharm. 2012;38:104-10 pubmed publisher
    b>Berberine chloride (BBR) is a plant alkaloid that has been used for centuries for treatment of inflammation, dysentery, and liver diseases...
  16. Wang Z, Hu H, Chen F, Lan K, Wang A. Reduced system exposures of total rhein and baicalin after combinatory oral administration of rhein, baicalin and berberine to beagle dogs and rats. J Ethnopharmacol. 2013;145:442-9 pubmed publisher
    Rhein (Rh), baicalin (BG) and berberine (Be) are important coexisted constituents of San-Huang-Xie-Xin-Tang, which was widely used in traditional Chinese medicine for the treatment of gastritis, hypertension, gastric bleeding and peptic ..
  17. Li Y, Ren G, Wang Y, Kong W, Yang P, Wang Y, et al. Bioactivities of berberine metabolites after transformation through CYP450 isoenzymes. J Transl Med. 2011;9:62 pubmed publisher
    b>Berberine (BBR) is a drug with multiple effects on cellular energy metabolism...
  18. Zhang L, Li J, Ma F, Yao S, Li N, Wang J, et al. Synthesis and cytotoxicity evaluation of 13-n-alkyl berberine and palmatine analogues as anticancer agents. Molecules. 2012;17:11294-302 pubmed
    By introducing long carbon-chain alkyl groups at the C-13 position of berberine and palmatine, 13-n-hexyl/13-n-octyl berberine and palmatine chloride analogues 4a-d were synthesized and examined by MTT assays for cytotoxic activity in ..
  19. Teodoro J, Duarte F, Gomes A, Varela A, Peixoto F, Rolo A, et al. Berberine reverts hepatic mitochondrial dysfunction in high-fat fed rats: a possible role for SirT3 activation. Mitochondrion. 2013;13:637-46 pubmed publisher
    b>Berberine is an isoquinoline alkaloid with anti-diabetic properties...
  20. Zhao Y, Hellum B, Liang A, Nilsen O. The in vitro inhibition of human CYP1A2, CYP2D6 and CYP3A4 by tetrahydropalmatine, neferine and berberine. Phytother Res. 2012;26:277-83 pubmed publisher
    ..inhibition potential of the three purified herbal constituents tetrahydropalmatine (Tet), neferine (Nef) and berberine (Ber) towards recombinant human CYP1A2, CYP2D6 and CYP3A4 metabolic activities...
  21. Hu J, Chai Y, Wang Y, Kheir M, Li H, Yuan Z, et al. PI3K p55? promoter activity enhancement is involved in the anti-apoptotic effect of berberine against cerebral ischemia-reperfusion. Eur J Pharmacol. 2012;674:132-42 pubmed publisher
    b>Berberine is a candidate clinical neuroprotective agent against ischemic stroke. In the present study, we examined the influence of the PI3K/Akt pathway in mediating the anti-apoptotic effects of berberine...
  22. Wu D, Wen W, Qi C, Zhao R, Lu J, Zhong C, et al. Ameliorative effect of berberine on renal damage in rats with diabetes induced by high-fat diet and streptozotocin. Phytomedicine. 2012;19:712-8 pubmed publisher
    b>Berberine (BBR) is one of the main constituents in Rhizoma coptidis and it has widely been used for the treatment of diabetic nephropathy...
  23. Lo T, Tsai W, Chen S. MicroRNA-21-3p, a berberine-induced miRNA, directly down-regulates human methionine adenosyltransferases 2A and 2B and inhibits hepatoma cell growth. PLoS ONE. 2013;8:e75628 pubmed publisher
    ..b>Berberine, an isoquinoline alkaloid isolated from many medicinal herbs such as Coptis chinensis, has a wide range of ..
  24. Guo Y, Pope C, Cheng X, Zhou H, Klaassen C. Dose-response of berberine on hepatic cytochromes P450 mRNA expression and activities in mice. J Ethnopharmacol. 2011;138:111-8 pubmed publisher
    b>Berberine is an isoquinoline alkaloid isolated from the root and bark of plants such as goldenseal, Berberis, and Chinese goldthread...
  25. Wu K, Yang Q, Mu Y, Zhou L, Liu Y, Zhou Q, et al. Berberine inhibits the proliferation of colon cancer cells by inactivating Wnt/?-catenin signaling. Int J Oncol. 2012;41:292-8 pubmed publisher
    ..In this study, we investigated the proliferation inhibitory effect of berberine on colon cancer cells and the molecular basis underlying this effect...
  26. Zhang Y, Wang X, Sha S, Liang S, Zhao L, Liu L, et al. Berberine increases the expression of NHE3 and AQP4 in sennosideA-induced diarrhoea model. Fitoterapia. 2012;83:1014-22 pubmed publisher
    b>Berberine, a compound isolated from Chinese Goldthread Rhizome, has been widely used as a non-prescription drug to treat diarrhoea in China...
  27. Domitrovic R, Cvijanovic O, Pernjak Pugel E, Skoda M, Mikelić L, Crncevic Orlic Z. Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative/nitrosative stress, inflammation, autophagy and apoptosis. Food Chem Toxicol. 2013;62:397-406 pubmed publisher
    The aim of this study was to investigate the therapeutic activity of isoquinoline alkaloid berberine against cisplatin (CP)-induced nephrotoxicity in mice...
  28. Li J, Gu L, Zhang H, Liu T, Tian D, Zhou M, et al. Berberine represses DAXX gene transcription and induces cancer cell apoptosis. Lab Invest. 2013;93:354-64 pubmed publisher
    ..Regulation of DAXX gene expression remains largely obscure. We recently reported that berberine (BBR), a natural product derived from a plant used in Chinese herbal medicine, downregulates DAXX expression at ..
  29. Li H, Li X, Zhang M, Xu H, Wang C, Wang S, et al. Berberine ameliorates experimental autoimmune neuritis by suppressing both cellular and humoral immunity. Scand J Immunol. 2014;79:12-9 pubmed publisher
    b>Berberine (BBR), an isoquinoline derivative alkaloid, has been extensively used in traditional Chinese medicine for the treatment of diarrhoea, rheumatic diseases, diabetes, etc...
  30. Shan W, Huang L, Zhou Q, Meng F, Li X. Synthesis, biological evaluation of 9-N-substituted berberine derivatives as multi-functional agents of antioxidant, inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-? aggregation. Eur J Med Chem. 2011;46:5885-93 pubmed publisher
    A series of 9-N-substituted berberine derivatives were synthesized and biologically evaluated as antioxidant and inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase and amyloid-? aggregation...
  31. Moon P, Choi I, Kim H. Berberine inhibits the production of thymic stromal lymphopoietin by the blockade of caspase-1/NF-?B pathway in mast cells. Int Immunopharmacol. 2011;11:1954-9 pubmed publisher
    ..However, it has not been clarified the effect of berberine (BER) on the production of TSLP yet...
  32. Wang Q, Zhang M, Liang B, Shirwany N, Zhu Y, Zou M. Activation of AMP-activated protein kinase is required for berberine-induced reduction of atherosclerosis in mice: the role of uncoupling protein 2. PLoS ONE. 2011;6:e25436 pubmed publisher
    b>Berberine, a botanical alkaloid purified from Coptidis rhizoma, is reported to activate the AMP-activated protein kinase (AMPK). Whether AMPK is required for the protective effects of berberine in cardiovascular diseases remains unknown...
  33. Wu Y, Li J, Kim Y, Wu J, Wang Q, Hao Y. In vivo and in vitro antiviral effects of berberine on influenza virus. Chin J Integr Med. 2011;17:444-52 pubmed publisher
    To explore the potential effects of berberine on influenza virus infection both in vitro and in vivo...
  34. Han J, Lin H, Huang W. Modulating gut microbiota as an anti-diabetic mechanism of berberine. Med Sci Monit. 2011;17:RA164-7 pubmed
    b>Berberine, one of the main constituents of a Chinese traditional herb used to treat bacterial diarrhea, has an effect of lowering glucose, which has been recently confirmed by many studies...
  35. Wang T, Wang N, Song H, Xi X, Wang J, Hao A, et al. Preparation of an anhydrous reverse micelle delivery system to enhance oral bioavailability and anti-diabetic efficacy of berberine. Eur J Pharm Sci. 2011;44:127-35 pubmed publisher
    To enhance oral bioavailability and anti-diabetic efficacy of berberine (BER), an anhydrous reverse micelle (ARM) delivery system was prepared through lyophilization of water-in-oil (W/O) emulsions...
  36. Huang K, Liu W, Lan T, Xie X, Peng J, Huang J, et al. Berberine reduces fibronectin expression by suppressing the S1P-S1P2 receptor pathway in experimental diabetic nephropathy models. PLoS ONE. 2012;7:e43874 pubmed publisher
    ..Among the five S1P receptors, the activation of S1P2 receptor is the most abundant. Berberine (BBR) treatment also effectively inhibits SphK1 activity and S1P production in the kidneys of diabetic models, ..
  37. Patil S, Dash R, Anandjiwala S, Nivsarkar M. Simultaneous quantification of berberine and lysergol by HPLC-UV: evidence that lysergol enhances the oral bioavailability of berberine in rats. Biomed Chromatogr. 2012;26:1170-5 pubmed publisher
    A sensitive and simple HPLC method was developed for the simultaneous quantification of berberine and lysergol in rat plasma...
  38. Hsu Y, Tseng Y, Lo Y. Berberine, a natural antidiabetes drug, attenuates glucose neurotoxicity and promotes Nrf2-related neurite outgrowth. Toxicol Appl Pharmacol. 2013;272:787-96 pubmed publisher
    ..b>Berberine (BBR), a natural antidiabetes drug with PI3K-activating activity, holds promise for diabetes because of its dual ..
  39. Zhao H, Sui Y, Qiao C, Yip K, Leung R, Tsui S, et al. Sustained antidiabetic effects of a berberine-containing Chinese herbal medicine through regulation of hepatic gene expression. Diabetes. 2012;61:933-43 pubmed publisher
    ..In this study, we used a three-herb, berberine-containing TCM to treat male Zucker diabetic fatty rats...
  40. Li J, Cao B, Liu X, Fu X, Xiong Z, Chen L, et al. Berberine suppresses androgen receptor signaling in prostate cancer. Mol Cancer Ther. 2011;10:1346-56 pubmed publisher
    ..In this study, we investigated the effect of berberine on AR signaling in prostate cancer. We report that berberine decreased the transcriptional activity of AR...
  41. Chitra P, Saiprasad G, Manikandan R, Sudhandiran G. Berberine attenuates bleomycin induced pulmonary toxicity and fibrosis via suppressing NF-?B dependant TGF-? activation: a biphasic experimental study. Toxicol Lett. 2013;219:178-93 pubmed publisher
    ..Thus, it becomes great interest to find novel agents to treat IPF. Berberine, a plant alkaloid known for its broad pharmacological activities remains a remedy against multiple diseases...
  42. Chappell W, Abrams S, Franklin R, Lahair M, Montalto G, Cervello M, et al. Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine. Cell Cycle. 2012;11:4447-61 pubmed publisher
    ..MCF-7 breast cancer cells to EGFR, Bcl-2 and calmodulin kinase inhibitors as well as the natural plant product berberine. Furthermore, when suboptimal concentrations of certain inhibitors were combined with doxorubicin, a reduction ..
  43. Wu Y, Chuang S, Hong W, Lai Y, Chang G, Pang J. Berberine reduces leukocyte adhesion to LPS-stimulated endothelial cells and VCAM-1 expression both in vivo and in vitro. Int J Immunopathol Pharmacol. 2012;25:741-50 pubmed
    Leukocyte adhesion to endothelium plays a critical initiating role in inflammation. Berberine, an anti-inflammatory natural compound, is known to attenuate lipopolysaccharide (LPS)-induced lung injury and improve survival of endotoxemic ..
  44. Xiao N, Chen S, Ma Y, Qiu J, Tan J, Ou T, et al. Interaction of Berberine derivative with protein POT1 affect telomere function in cancer cells. Biochem Biophys Res Commun. 2012;419:567-72 pubmed publisher
    ..As we know, compound Sysu-00692 is the first reported POT1-binding ligand, which could serve as a lead compound for further improvement. This work offered a potentially new approach for drug design for the treatment of cancers. ..
  45. Hamsa T, Kuttan G. Berberine inhibits pulmonary metastasis through down-regulation of MMP in metastatic B16F-10 melanoma cells. Phytother Res. 2012;26:568-78 pubmed publisher
    The present study demonstrated the potential antimetastatic and antiinvasive effect of berberine using both in vivo mouse lung metastasis and in vitro models...
  46. Liu Q, Jiang H, Liu Z, Wang Y, Zhao M, Hao C, et al. Berberine radiosensitizes human esophageal cancer cells by downregulating homologous recombination repair protein RAD51. PLoS ONE. 2011;6:e23427 pubmed publisher
    ..We here reported the discovery of berberine as a potent radiosensitizing agent on ESCC cells...
  47. Kuo H, Chuang T, Yeh M, Hsu S, Way T, Chen P, et al. Growth suppression of HER2-overexpressing breast cancer cells by berberine via modulation of the HER2/PI3K/Akt signaling pathway. J Agric Food Chem. 2011;59:8216-24 pubmed publisher
    b>Berberine (BBR) is a natural alkaloid with significant antitumor activities against many types of cancer cells...
  48. Xu L, Lu B, Hu M, Xu Y, Han X, Qi Y, et al. Mechanisms involved in the cytotoxic effects of berberine on human colon cancer HCT-8 cells. Biocell. 2012;36:113-20 pubmed
    b>Berberine, a constituent of some traditional Chinese medicinal plants, has been reported to have cytotoxicity effects on different human cancer cell lines...
  49. Zhang X, Zhao Y, Zhang M, Pang X, Xu J, Kang C, et al. Structural changes of gut microbiota during berberine-mediated prevention of obesity and insulin resistance in high-fat diet-fed rats. PLoS ONE. 2012;7:e42529 pubmed publisher
    b>Berberine, a major pharmacological component of the Chinese herb Coptis chinensis, which was originally used to treat bacterial diarrhea, has recently been demonstrated to be clinically effective in alleviating type 2 diabetes...
  50. He W, Wang B, Zhuang Y, Shao D, Sun K, Chen J. Berberine inhibits growth and induces G1 arrest and apoptosis in human cholangiocarcinoma QBC939 cells. J Pharmacol Sci. 2012;119:341-8 pubmed
    ..Here we report that in vitro treatment of human cholangiocarcinoma QBC939 cells with berberine, a naturally occurring isoquinoline alkaloid, decreased cell viability and induced cell death in a dose-..
  51. Tillhon M, Guamán Ortiz L, Lombardi P, Scovassi A. Berberine: new perspectives for old remedies. Biochem Pharmacol. 2012;84:1260-7 pubmed publisher
    ..Among them, the natural isoquinoline alkaloid berberine has been employed in Ayurvedic and Chinese Medicine for hundreds of years with a wide range of pharmacological ..
  52. Goto H, Kariya R, Shimamoto M, Kudo E, Taura M, Katano H, et al. Antitumor effect of berberine against primary effusion lymphoma via inhibition of NF-?B pathway. Cancer Sci. 2012;103:775-81 pubmed publisher
    ..In this study, we assessed the antitumor effect of berberine, a naturally occurring isoquinoline alkaloid, on this pathway...
  53. Tian P, Ge H, Liu H, Kern T, Du L, Guan L, et al. Leukocytes from diabetic patients kill retinal endothelial cells: effects of berberine. Mol Vis. 2013;19:2092-105 pubmed
    ..The present study was designed to investigate whether leukocytes from diabetic patients could kill retinal endothelial cells and whether that cytotoxicity could be inhibited in vivo by administration of berberine.