ondansetron

Summary

Summary: A competitive serotonin type 3 receptor antagonist. It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.

Top Publications

  1. Rojas C, Stathis M, Thomas A, Massuda E, Massuda E, Alt J, et al. Palonosetron exhibits unique molecular interactions with the 5-HT3 receptor. Anesth Analg. 2008;107:469-78 pubmed publisher
    ..However, these attributes alone are not sufficient to explain the results with palonosetron. We sought to elucidate additional differences among 5-HT(3)-RAs that could help explain the observations in the clinic...
  2. Tzvetkov M, Saadatmand A, Bokelmann K, Meineke I, Kaiser R, Brockmoller J. Effects of OCT1 polymorphisms on the cellular uptake, plasma concentrations and efficacy of the 5-HT(3) antagonists tropisetron and ondansetron. Pharmacogenomics J. 2012;12:22-9 pubmed publisher
    After uptake into liver cells, the antiemetic drugs tropisetron and ondansetron undergo metabolic inactivation by cytochrome P450 2D6 (CYP2D6)...
  3. Stamer U, Lee E, Rauers N, Zhang L, Kleine Brueggeney M, Fimmers R, et al. CYP2D6- and CYP3A-dependent enantioselective plasma concentrations of ondansetron in postanesthesia care. Anesth Analg. 2011;113:48-54 pubmed publisher
    An influence of polymorphic cytochromes P450 (CYP) 2D6 genetic variants on antiemetic efficacy of ondansetron has been suggested. However, the role of CYP3A in ondansetron metabolism and efficacy has been unclear...
  4. Kenna G, Zywiak W, McGeary J, Leggio L, McGeary C, Wang S, et al. A within-group design of nontreatment seeking 5-HTTLPR genotyped alcohol-dependent subjects receiving ondansetron and sertraline. Alcohol Clin Exp Res. 2009;33:315-23 pubmed publisher
    ..The aim of this study was to match and mismatch L/L, S/S, or S/L genotypes with administration of ondansetron and sertraline...
  5. Charbit B, Alvarez J, Dasque E, Abe E, Demolis J, Funck Brentano C. Droperidol and ondansetron-induced QT interval prolongation: a clinical drug interaction study. Anesthesiology. 2008;109:206-12 pubmed publisher
    Droperidol and ondansetron have previously been found to prolong the QT interval in the treatment of postoperative nausea and vomiting...
  6. Liu F, Liu F, Yu H. Ondansetron attenuates hepatic injury via p38 MAPK-dependent pathway in a rat haemorrhagic shock model. Resuscitation. 2011;82:335-40 pubmed publisher
    b>Ondansetron is a 5-HT3 receptor antagonist with potent antiemetic, analgesic, and antiphlogistic effects. Recent evidence suggests that the co-existence of 5-HT3 receptors in various cell types is involved in inflammation...
  7. Kim S, Kim S, Baek Y, Ok S, Kim S. Comparison of ramosetron with ondansetron for prevention of postoperative nausea and vomiting in patients undergoing gynaecological surgery. Br J Anaesth. 2009;103:549-53 pubmed publisher
    ..evaluate the efficacy of ramosetron for the prevention of postoperative nausea and vomiting (PONV) with that of ondansetron or placebo in high-risk patients undergoing gynaecological surgery...
  8. Pfeil N, Uhlig U, Kostev K, Carius R, Schroder H, Kiess W, et al. Antiemetic medications in children with presumed infectious gastroenteritis--pharmacoepidemiology in Europe and Northern America. J Pediatr. 2008;153:659-62, 662.e1-3 pubmed publisher
    ..b>Ondansetron was used in a minor proportion of antiemetic prescriptions (Germany, Canada, Spain, and Italy, 0%; United ..
  9. Yeh Y, McDonnell A, Klinger E, Fowler B, Matta L, Voit D, et al. Comparison of healthcare resource use between patients receiving ondansetron or palonosetron as prophylaxis for chemotherapy-induced nausea and vomiting. J Oncol Pharm Pract. 2011;17:179-85 pubmed publisher
    To analyze the differences between ondansetron and palonosetron in healthcare resource use (i.e., inpatient/ outpatient encounters) among patients receiving intraperitoneal cisplatin. A medical record review was performed...

More Information

Publications62

  1. Wildeboer K, Zheng L, Choo K, Stevens K. Ondansetron results in improved auditory gating in DBA/2 mice through a cholinergic mechanism. Brain Res. 2009;1300:41-50 pubmed publisher
    The 5-HT(3) receptor antagonist, ondansetron, has been shown to correct the auditory gating deficit in medicated schizophrenia patients...
  2. Minville V, Fourcade O, Mazoit J, Girolami J, Tack I. Ondansetron does not block paracetamol-induced analgesia in a mouse model of fracture pain. Br J Anaesth. 2011;106:112-8 pubmed publisher
    The aim of this study was to assess any interaction between ondansetron and paracetamol on a model of post-fracture pain in mice...
  3. Roslund G, Hepps T, McQuillen K. The role of oral ondansetron in children with vomiting as a result of acute gastritis/gastroenteritis who have failed oral rehydration therapy: a randomized controlled trial. Ann Emerg Med. 2008;52:22-29.e6 pubmed
    We hypothesize that ondansetron will facilitate oral rehydration therapy in children with acute gastritis or acute gastroenteritis and mild to moderate dehydration who fail initial oral rehydration therapy...
  4. Mattiuzzi G, Cortes J, Blamble D, Bekele B, Xiao L, Cabanillas M, et al. Daily palonosetron is superior to ondansetron in the prevention of delayed chemotherapy-induced nausea and vomiting in patients with acute myelogenous leukemia. Cancer. 2010;116:5659-66 pubmed publisher
    ..Nausea and vomiting in patients with acute myelogenous leukemia (AML) can be from various causes, including the use of high-dose cytarabine...
  5. Basu A, Saha D, Hembrom B, Roy A, Naaz A. Comparison of palanosetron, granisetron and ondansetron as anti-emetics for prevention of postoperative nausea and vomiting in patients undergoing middle ear surgery. J Indian Med Assoc. 2011;109:327-9 pubmed
    The objective of the study was to compare the efficacy of palanosetron (0.25 mg), granisetron (3.0 mg) and ondansetron (8...
  6. Rosow C, Haspel K, Smith S, Grecu L, Bittner E. Haloperidol versus ondansetron for prophylaxis of postoperative nausea and vomiting. Anesth Analg. 2008;106:1407-9, table of contents pubmed publisher
    ..Two hundred forty-four adults were randomized to receive i.v. haloperidol 1 mg or ondansetron 4 mg, during general anesthesia...
  7. Braude D, Crandall C. Ondansetron versus promethazine to treat acute undifferentiated nausea in the emergency department: a randomized, double-blind, noninferiority trial. Acad Emerg Med. 2008;15:209-15 pubmed publisher
    The authors sought to compare ondansetron and promethazine among emergency department (ED) patients with undifferentiated nausea...
  8. Singla N, Singla S, Chung F, Kutsogiannis D, Blackburn L, Lane S, et al. Phase II study to evaluate the safety and efficacy of the oral neurokinin-1 receptor antagonist casopitant (GW679769) administered with ondansetron for the prevention of postoperative and postdischarge nausea and vomiting in high-risk patients. Anesthesiology. 2010;113:74-82 pubmed publisher
    ..of the neurokinin-1 receptor antagonist casopitant improved the antiemetic efficacy of an intravenous dose of ondansetron hydrochloride...
  9. Erhan Y, Erhan E, Aydede H, Yumus O, Yentur A. Ondansetron, granisetron, and dexamethasone compared for the prevention of postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy : A randomized placebo-controlled study. Surg Endosc. 2008;22:1487-92 pubmed
    ..This study was designed to compare the effectiveness of ondansetron, granisetron, and dexamethasone for the prevention of PONV in patients after laparoscopic cholecystectomy...
  10. Sandhu T, Tanvatcharaphan P, Cheunjongkolkul V. Ondansetron versus metoclopramide in prophylaxis of nausea and vomiting for laparoscopic cholecystectomy: a prospective double-blind randomized study. Asian J Surg. 2008;31:50-4 pubmed publisher
    ..This prospective, randomized, double-blind study compared the prophylactic use of metoclopramide and ondansetron for the treatment of postoperative nausea and vomiting in patients who underwent elective laparoscopic ..
  11. Jain S, Agarwal N, Mediratta P, Sharma K. Evaluation of anticonvulsant and nootropic effect of ondansetron in mice. Hum Exp Toxicol. 2012;31:905-12 pubmed
    The role of serotonin receptors have been implicated in various types of experimentally induced seizures. Ondansetron is a highly selective 5-hydroxytryptamine 3 (5-HT(3)) receptor antagonist used as antiemetic agent for chemotherapy-, ..
  12. Weissenburger J, Funck Brentano C, Jaillon P, Charbit B. Droperidol and ondansetron in vitro electrophysiological drug interaction study. Fundam Clin Pharmacol. 2009;23:719-26 pubmed publisher
    Droperidol and ondansetron are potent anti-emetic agents which are often administered together...
  13. Yang S, Suh J, Lee M. Pharmacokinetic interaction between tamoxifen and ondansetron in rats: non-competitive (hepatic) and competitive (intestinal) inhibition of tamoxifen metabolism by ondansetron via CYP2D subfamily and 3A1/2. Cancer Chemother Pharmacol. 2010;65:407-18 pubmed publisher
    Tamoxifen and ondansetron were commonly metabolized via rat hepatic CYP2D subfamily and 3A1/2, and ondansetron is used to treat chemotherapy-induced nausea...
  14. Singh N, Rai A, Selhorst J, Acharya J. Ondansetron and seizures. Epilepsia. 2009;50:2663-6 pubmed publisher
    ..b>Ondansetron, a 5-HT(3) receptor antagonist, has been reported to have proconvulsant and anticonvulsant effects in animals...
  15. El Deeb A, Ahmady M. Effect of acupuncture on nausea and/or vomiting during and after cesarean section in comparison with ondansetron. J Anesth. 2011;25:698-703 pubmed publisher
    ..This study compared the effect of electrical acustimulation with ondansetron for preventing intraoperative and postoperative emetic symptoms and improving patient satisfaction.
  16. Moon Y, Joo J, Kim J, Lee Y. Anti-emetic effect of ondansetron and palonosetron in thyroidectomy: a prospective, randomized, double-blind study. Br J Anaesth. 2012;108:417-22 pubmed publisher
    ..This study compared the effects of i.v. ondansetron and palonosetron administered at the end of surgery in preventing postoperative nausea and vomiting (PONV) in ..
  17. Alghanem S, Massad I, Rashed E, Abu Ali H, Daradkeh S. Optimization of anesthesia antiemetic measures versus combination therapy using dexamethasone or ondansetron for the prevention of postoperative nausea and vomiting. Surg Endosc. 2010;24:353-8 pubmed publisher
    ..Propofol-based total intravenous anesthesia (TIVA), ondansetron, and dexamethasone each are reported to reduce PONV by approximately 30%...
  18. Akhondzadeh S, Mohammadi N, Noroozian M, Karamghadiri N, Ghoreishi A, Jamshidi A, et al. Added ondansetron for stable schizophrenia: a double blind, placebo controlled trial. Schizophr Res. 2009;107:206-12 pubmed publisher
    ..The purpose of this study was to assess the efficacy of ondansetron, a 5-HT3 receptor antagonist as an adjuvant agent in the treatment of chronic schizophrenia in particular for ..
  19. Choi Y, Shim J, Yoon D, Jeon D, Lee J, Kwak Y. Effect of ramosetron on patient-controlled analgesia related nausea and vomiting after spine surgery in highly susceptible patients: comparison with ondansetron. Spine (Phila Pa 1976). 2008;33:E602-6 pubmed publisher
    A prospective, randomized, double-blind clinical trial. To compare the effect of ramosetron with that of ondansetron on opioid-based IV patient-controlled analgesia (PCA) related postoperative nausea and vomiting (PONV) in highly ..
  20. Pallanti S, Bernardi S, Antonini S, Singh N, Hollander E. Ondansetron augmentation in treatment-resistant obsessive-compulsive disorder: a preliminary, single-blind, prospective study. CNS Drugs. 2009;23:1047-55 pubmed publisher
    ..indirect inhibitors of cortico-mesolimbic dopamine release, augmentation with the 5-HT(3) receptor antagonist ondansetron in combination with SSRIs and antipsychotics has potential efficacy in treatment-resistant OCD patients...
  21. McKechnie K, Froese A. Ventricular tachycardia after ondansetron administration in a child with undiagnosed long QT syndrome. Can J Anaesth. 2010;57:453-7 pubmed publisher
    To describe a case of ventricular tachycardia after co-administration of ondansetron and dimenhydrinate to a child with occult congenital QT prolongation.
  22. Grover V, Mathew P, Hegde H. Efficacy of orally disintegrating ondansetron in preventing postoperative nausea and vomiting after laparoscopic cholecystectomy: a randomised, double-blind placebo controlled study. Anaesthesia. 2009;64:595-600 pubmed publisher
    Peri-operative prophylactic anti-emetics are commonly used parenterally. Orally disintegrating ondansetron is efficacious during chemotherapy...
  23. Raymond S. A survey of prescribing for the management of nausea and vomiting in pregnancy in Australasia. Aust N Z J Obstet Gynaecol. 2013;53:358-62 pubmed publisher
    ..For hyperemesis gravidarum, 86% prescribe metoclopramide and 75% ondansetron. Despite guidelines suggesting the use of antihistamines and dopamine agonists (phenothiazines), very few ..
  24. Dizdar V, Gilja O, Hausken T. Increased visceral sensitivity in Giardia-induced postinfectious irritable bowel syndrome and functional dyspepsia. Effect of the 5HT3-antagonist ondansetron. Neurogastroenterol Motil. 2007;19:977-82 pubmed
    ..with persisting abdominal symptoms after Giardia infection and assessed the effect of 5HT(3)-antagonist ondansetron. Twenty-two patients with Giardia negative stools and 19 controls were included...
  25. Hahm T, Ko J, Choi S, Gwak M. Comparison of the prophylactic anti-emetic efficacy of ramosetron and ondansetron in patients at high-risk for postoperative nausea and vomiting after total knee replacement. Anaesthesia. 2010;65:500-4 pubmed publisher
    We compared the prophylactic anti-emetic efficacy of ramosetron, a newly developed 5-HT(3) antagonist, and ondansetron in patients at high-risk for postoperative nausea and vomiting after total knee replacement...
  26. Tuerke K, Winters B, Parker L. Ondansetron interferes with unconditioned lying-on belly and acquisition of conditioned gaping induced by LiCl as models of nausea-induced behaviors in rats. Physiol Behav. 2012;105:856-60 pubmed publisher
    ..Here we compared the effectiveness of the anti-nausea drug, ondansetron (OND) to interfere with the establishment of conditioned gaping reactions and the unconditional malaise-induced ..
  27. Feinberg B, Gilmore J, Haislip S, Jackson J, Jain G, Balu S, et al. Impact of initiating antiemetic prophylaxis with palonosetron versus ondansetron on risk of uncontrolled chemotherapy-induced nausea and vomiting in patients with lung cancer receiving multi-day chemotherapy. Support Care Cancer. 2012;20:615-23 pubmed publisher
    ..the risk of uncontrolled chemotherapy-induced nausea/vomiting (CINV) among lung cancer patients receiving multi-day chemotherapy and ondansetron- or palonosetron-initiated prophylactic antiemetic regimens in a community oncology setting.
  28. Habib A, Keifer J, Borel C, White W, Gan T. A comparison of the combination of aprepitant and dexamethasone versus the combination of ondansetron and dexamethasone for the prevention of postoperative nausea and vomiting in patients undergoing craniotomy. Anesth Analg. 2011;112:813-8 pubmed publisher
    Postoperative nausea and vomiting (PONV) occur commonly after craniotomy. In patients receiving prophylaxis with ondansetron and dexamethasone, vomiting occurred in 45% of patients at 48 hours...
  29. Schwartzberg L, Barbour S, Morrow G, Ballinari G, Thorn M, Cox D. Pooled analysis of phase III clinical studies of palonosetron versus ondansetron, dolasetron, and granisetron in the prevention of chemotherapy-induced nausea and vomiting (CINV). Support Care Cancer. 2014;22:469-77 pubmed publisher
    ..This analysis was undertaken to assess the relative efficacy and safety of palonosetron versus older 5HT3 RAs in preventing CINV associated with moderately or highly emetogenic chemotherapy...
  30. Real C, Seif I, Adrien J, Escourrou P. Ondansetron and fluoxetine reduce sleep apnea in mice lacking monoamine oxidase A. Respir Physiol Neurobiol. 2009;168:230-8 pubmed publisher
    ..fluoxetine is beneficial to some patients with obstructive apnea, whereas the 5-HT(3) receptor antagonist ondansetron seems of little value despite its efficacy in rat and dog models of sleep apnea (central and obstructive)...
  31. Peters C, Hayashida K, Ewan E, Nakajima K, Obata H, Xu Q, et al. Lack of analgesic efficacy of spinal ondansetron on thermal and mechanical hypersensitivity following spinal nerve ligation in the rat. Brain Res. 2010;1352:83-93 pubmed publisher
    ..To test this, we acutely injected intrathecal ondansetron in rats between 14 and 30 days after SNL and assessed effects on thermal and mechanical hypersensitivity...
  32. Sah N, Ramesh V, Kaul B, Dalby P, Shestak K, Vallejo M. Transdermal scopolamine patch in addition to ondansetron for postoperative nausea and vomiting prophylaxis in patients undergoing ambulatory cosmetic surgery. J Clin Anesth. 2009;21:249-52 pubmed publisher
    To determine the efficacy of transdermal scopolamine in addition to ondansetron in decreasing the incidence of postoperative nausea and vomiting (PONV).
  33. Koren G. Motherisk update. Is ondansetron safe for use during pregnancy?. Can Fam Physician. 2012;58:1092-3 pubmed
    ..for morning sickness, some of my patients with severe nausea and vomiting of pregnancy (NVP) receive ondansetron in hospital. I have read some new precautions recommended by the US Food and Drug Administration (FDA)...
  34. Choi D, Chin J, Lee E, Lim O, Chung C, Ro Y, et al. Prophylactic control of post-operative nausea and vomiting using ondansetron and ramosetron after cardiac surgery. Acta Anaesthesiol Scand. 2010;54:962-9 pubmed publisher
    The aim of this study was to evaluate the efficacy of ondansetron and ramosetron in the reduction of post-operative nausea and vomiting (PONV) associated with patient-controlled analgesia (PCA) after cardiac surgery...
  35. Krobbuaban B, Pitakpol S, Diregpoke S. Ondansetron vs. metoclopramide for the prevention of nausea and vomiting after gynecologic surgery. J Med Assoc Thai. 2008;91:669-74 pubmed
    ..The present study was designed to compare the efficacy and safety of ondansetron with metoclopramide for prophylaxis of PONV in patients undergoing major gynecological surgery.
  36. Song J, Park E, Lee J, Park Y, Kang B, Shim Y. The effect of combining dexamethasone with ondansetron for nausea and vomiting associated with fentanyl-based intravenous patient-controlled analgesia. Anaesthesia. 2011;66:263-7 pubmed publisher
    We investigated whether combined dexamethasone and ondansetron is more effective than ondansetron alone in preventing postoperative nausea and vomiting in patients with fentanyl-based intravenous patient-controlled analgesia...
  37. Pasternak B, Svanström H, Hviid A. Ondansetron in pregnancy and risk of adverse fetal outcomes. N Engl J Med. 2013;368:814-23 pubmed publisher
    b>Ondansetron is frequently used to treat nausea and vomiting during pregnancy, but the safety of this drug for the fetus has not been well studied...
  38. Silva S, Hu L, Sousa J, Pais A, Michniak Kohn B. A combination of nonionic surfactants and iontophoresis to enhance the transdermal drug delivery of ondansetron HCl and diltiazem HCl. Eur J Pharm Biopharm. 2012;80:663-73 pubmed publisher
    ..C(12)E(5,) and C(12)E(8)) as skin permeation enhancers in the transdermal drug delivery of two drugs: ondansetron hydrochloride and diltiazem hydrochloride, formulated as hydrogels...
  39. Ferreira E, Gillet M, Lelievre J, Bussières J. Ondansetron use during pregnancy: a case series. J Popul Ther Clin Pharmacol. 2012;19:e1-e10 pubmed
    This is a descriptive retrospective case series of 14 pregnant women treated with ondansetron for hyperemesis gravidarum (HG) at CHU Sainte-Justine, from January 2002 to October 2011...
  40. Cruz N, Portilla P, Vela R. Timing of ondansetron administration to prevent postoperative nausea and vomiting. P R Health Sci J. 2008;27:43-7 pubmed
    The original guidelines for using ondansetron recommending its administration prior to induction of anesthesia have been questioned.
  41. Oksuz H, Zencirci B, Ezberci M. Comparison of the effectiveness of metoclopramide, ondansetron, and granisetron on the prevention of nausea and vomiting after laparoscopic cholecystectomy. J Laparoendosc Adv Surg Tech A. 2007;17:803-8 pubmed
    ..The aim of the current study was to compare the antiemetic activity of different 5-hydroxytryptamine-3 receptor antagonists with that of metoclopramide...
  42. Vallejo M, Phelps A, Ibinson J, Barnes L, Milord P, Romeo R, et al. Aprepitant plus ondansetron compared with ondansetron alone in reducing postoperative nausea and vomiting in ambulatory patients undergoing plastic surgery. Plast Reconstr Surg. 2012;129:519-26 pubmed publisher
    ..This study evaluated the efficacy of a neurokinin-1 receptor antagonist (aprepitant) in reducing postoperative symptoms for up to 48 hours in patients undergoing outpatient plastic surgery...
  43. Ryu J, So Y, Hwang J, Do S. Ramosetron versus ondansetron for the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy. Surg Endosc. 2010;24:812-7 pubmed publisher
    ..This study compared ramosetron and ondansetron in terms of efficacy for PONV prevention after laparoscopic cholecystectomy...
  44. Kim S, Kim E, Nam K, Chang D, Nam S, Kim K. Postoperative intravenous patient-controlled analgesia in thyroid surgery: comparison of fentanyl and ondansetron regimens with and without the nonsteriodal anti-inflammatory drug ketorolac. Thyroid. 2008;18:1285-90 pubmed publisher
    ..All groups received 12 mg ondansetron (a serotonin 5-HT(3) receptor antagonist). In addition, Group I received the opioid fentanyl, 15 microg/kg...
  45. Bhatnagar S, Gupta D, Mishra S, Srikanti M, Singh M, Arora R. Preemptive antiemesis in patients undergoing modified radical mastectomy: oral granisetron versus oral ondansetron in a double-blind, randomized, controlled study. J Clin Anesth. 2007;19:512-6 pubmed
    To assess the efficacy of oral granisetron versus oral ondansetron for preemptive antiemesis in women undergoing modified radical mastectomy. Randomized, double-blind, controlled study. Metropolitan hospital...
  46. Riad W, Marouf H. Combination therapy in the prevention of PONV after strabismus surgery in children: granisetron, ondansetron, midazolam with dexamethasone. Middle East J Anaesthesiol. 2009;20:431-6 pubmed
    ..The aim of this study was to investigate the effect of granisetron, ondansetron, midazolam combination with dexamethasone in the prevention of PONV following strabismus repair in pediatric ..
  47. Dogrul A, Ossipov M, Porreca F. Differential mediation of descending pain facilitation and inhibition by spinal 5HT-3 and 5HT-7 receptors. Brain Res. 2009;1280:52-9 pubmed publisher
    ..Spinal administration of the 5-HT7 antagonist SB-269970, but not of the 5-HT3 antagonist ondansetron, blocked the antinociceptive effects of RVM morphine...
  48. Prasad B, Radulovacki M, Olopade C, Herdegen J, Logan T, Carley D. Prospective trial of efficacy and safety of ondansetron and fluoxetine in patients with obstructive sleep apnea syndrome. Sleep. 2010;33:982-9 pubmed
    ..We aimed to test the hypothesis that a combination of ondansetron (Ond) and fluoxetine (Fl) may effectively reduce expression of disordered breathing during REM and NREM sleep ..
  49. Diemunsch P, Gan T, Philip B, Girao M, Eberhart L, Irwin M, et al. Single-dose aprepitant vs ondansetron for the prevention of postoperative nausea and vomiting: a randomized, double-blind phase III trial in patients undergoing open abdominal surgery. Br J Anaesth. 2007;99:202-11 pubmed
    ..We compared aprepitant with ondansetron for prevention of postoperative nausea and vomiting...
  50. Gwak H, Oh I, Chun I. Transdermal delivery of ondansetron hydrochloride: effects of vehicles and penetration enhancers. Drug Dev Ind Pharm. 2004;30:187-94 pubmed
    The effects of vehicles and penetration enhancers on the in vitro permeation of ondansetron hydrochloride (OS) across dorsal hairless mouse skins were investigated...
  51. Pan P, Moore C. Comparing the efficacy of prophylactic metoclopramide, ondansetron, and placebo in cesarean section patients given epidural anesthesia. J Clin Anesth. 2001;13:430-5 pubmed
    To compare the relative efficacy of prophylactic metoclopramide, ondansetron, and placebo in nonemergent cesarean section patients given epidural anesthesia intraoperatively and for the first 24-hour period after delivery...
  52. Arcioni R, della Rocca M, Romanò S, Romano R, Pietropaoli P, Gasparetto A. Ondansetron inhibits the analgesic effects of tramadol: a possible 5-HT(3) spinal receptor involvement in acute pain in humans. Anesth Analg. 2002;94:1553-7, table of contents pubmed
    ..role of serotonin receptor subtype 3 (5-HT(3)), we evaluated the effects of a coadministration of ondansetron, a 5-HT(3) selective antagonist, and tramadol, a central analgesic dependent on enhanced serotonergic ..
  53. de Wit R, de Boer A, vd Linden G, Stoter G, Sparreboom A, Verweij J. Effective cross-over to granisetron after failure to ondansetron, a randomized double blind study in patients failing ondansetron plus dexamethasone during the first 24 hours following highly emetogenic chemotherapy. Br J Cancer. 2001;85:1099-101 pubmed
    ..a randomized double blind trial of granisetron 3 mg plus dexamethasone 10 mg versus continued treatment with ondansetron 8 mg plus dexamethasone 10 mg in patients with protection failure on ondansetron 8 mg plus dexamethasone 10 mg ..