Summary: A purine base and a fundamental unit of ADENINE NUCLEOTIDES.

Top Publications

  1. Hosek J, Vančo J, Starha P, Paráková L, Trávníček Z. Effect of 2-chloro-substitution of adenine moiety in mixed-ligand gold(I) triphenylphosphine complexes on anti-inflammatory activity: the discrepancy between the in vivo and in vitro models. PLoS ONE. 2013;8:e82441 pubmed publisher
    A series of gold(I) triphenylphosphine (PPh3) complexes (1-9) involving 2-chloro-N6-(substituted-benzyl)adenine derivatives as N-donor ligands was synthesized and thoroughly characterized by relevant methods, including electrospray-..
  2. Moyle Heyrman G, Zaichuk T, Xi L, Zhang Q, Uhlenbeck O, Holmgren R, et al. Chemical map of Schizosaccharomyces pombe reveals species-specific features in nucleosome positioning. Proc Natl Acad Sci U S A. 2013;110:20158-63 pubmed publisher
    ..Although there is generally very good agreement between nucleosome maps generated by chemical cleavage and micrococcal nuclease digestion, the chemical map shows consistently higher nucleosome occupancy on DNA with high A/T content. ..
  3. Copeland K, Pellock S, Cox J, Cafiero M, Tschumper G. Examination of tyrosine/adenine stacking interactions in protein complexes. J Phys Chem B. 2013;117:14001-8 pubmed publisher
    The ?-stacking interactions between tyrosine amino acid side chains and adenine-bearing ligands are examined...
  4. Boitz J, Ullman B. Adenine and adenosine salvage in Leishmania donovani. Mol Biochem Parasitol. 2013;190:51-5 pubmed publisher Leishmania is unique among trypanosomatid pathogens since this genus expresses two distinct routes for adenine salvage: adenine phosphoribosyltransferase (APRT) and adenine deaminase (AAH)...
  5. Diwan V, Mistry A, Gobe G, Brown L. Adenine-induced chronic kidney and cardiovascular damage in rats. J Pharmacol Toxicol Methods. 2013;68:197-207 pubmed publisher
    ..Kidney damage can be induced in rats by chronic dietary adenine intake...
  6. Okabe C, Borges R, de Almeida D, Fanelli C, Barlette G, Machado F, et al. NF-?B activation mediates crystal translocation and interstitial inflammation in adenine overload nephropathy. Am J Physiol Renal Physiol. 2013;305:F155-63 pubmed publisher
    b>Adenine overload promotes intratubular crystal precipitation and interstitial nephritis. We showed recently that these abnormalities are strongly attenuated in mice knockout for Toll-like receptors-2, -4, MyD88, ASC, or caspase-1...
  7. Park M, Kim B, Kim K, Kim J, Kim S, Park J, et al. Antiviral efficacies of currently available rescue therapies for multidrug-resistant chronic hepatitis B. Clin Mol Hepatol. 2013;19:29-35 pubmed publisher
    ..There was a nonsignificant tendency toward better antiviral efficacy with ETV+ADV combination therapy compared to LAM+ADV combination therapy and ETV monotherapy for MDR CHB in Korea, where tenofovir is not yet available. ..
  8. Raczyńska E, Makowski M, Zientara Rytter K, Kolczyńska K, Stępniewski T, Hallmann M. Quantum-chemical studies on the favored and rare tautomers of neutral and redox adenine. J Phys Chem A. 2013;117:1548-59 pubmed publisher
    All possible twenty-three prototropic tautomers of neutral and redox adenine (nine amine and fourteen imine forms, including geometric isomerism of the exo ═NH group) were examined in vacuo {DFT(B3LYP)/6-311+G(d,p)}...
  9. Talhaoui I, Couv S, Ishchenko A, Kunz C, Sch r P, Saparbaev M. 7,8-Dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases. Nucleic Acids Res. 2013;41:912-23 pubmed publisher
    ..coli, we demonstrate that the excision of 8oxoA from 8oxoA•T and 8oxoA•G has an absolute requirement for TDG and MUG, respectively. The data establish that MUG and TDG can counteract the genotoxic effects of 8oxoA residues in vivo...

More Information


  1. Frieda K, Block S. Direct observation of cotranscriptional folding in an adenine riboswitch. Science. 2012;338:397-400 pubmed publisher
    ..follow the cotranscriptional folding of a nascent RNA and used it to monitor individual transcripts of the pbuE adenine riboswitch, visualizing distinct folding transitions...
  2. Kadowaki D, Sumikawa S, Arimizu K, Taguchi K, Kitamura K, Ishitsuka Y, et al. Effect of acetaminophen on the progression of renal damage in adenine induced renal failure model rats. Life Sci. 2012;91:1304-8 pubmed publisher
    ..Acetaminophen lacks the anti-inflammatory and anti-coagulatory properties of the NSAIDs. In this study, we investigate whether acetaminophen has an impact on the progression of renal failure...
  3. Kosi L, Reiberger T, Payer B, Grabmeier Pfistershammer K, Strassl R, Rieger A, et al. Five-year on-treatment efficacy of lamivudine-, tenofovir- and tenofovir + emtricitabine-based HAART in HBV-HIV-coinfected patients. J Viral Hepat. 2012;19:801-10 pubmed publisher
    ..TDF-based HAART leads to high rates of HBeAg seroconversion and HBsAg loss after 5 years of continuous exposure. One-third of HBV-HIV-coinfected patients may experience transient HAART-related hepatotoxicity. ..
  4. Yip B, Chaung K, Wong C, Trinh H, Nguyen H, Ahmed A, et al. Tenofovir monotherapy and tenofovir plus entecavir combination as rescue therapy for entecavir partial responders. Dig Dis Sci. 2012;57:3011-6 pubmed publisher
    ..Virologic response to entecavir + tenofovir combination therapy and tenofovir monotherapy appeared to be similar in most patients, but not with the entecavir + adefovir combination. ..
  5. Lin Y, Kuo H, Wang J, Lin W. Regulation of inflammatory response by 3-methyladenine involves the coordinative actions on Akt and glycogen synthase kinase 3? rather than autophagy. J Immunol. 2012;189:4154-64 pubmed publisher
  6. Bedimo R, Maalouf N, Zhang S, Drechsler H, Tebas P. Osteoporotic fracture risk associated with cumulative exposure to tenofovir and other antiretroviral agents. AIDS. 2012;26:825-31 pubmed publisher
    ..09 (CI 1.00-1.20, P = 0.051) in MV2. Cumulative exposure to TDF and, among protease inhibitors, LPV/RTV was independently predictive of increased risk of osteoporotic fracture in the HAART era. ..
  7. D Amici G, Mirasole C, D Alessandro A, Yoshida T, Dumont L, Zolla L. Red blood cell storage in SAGM and AS3: a comparison through the membrane two-dimensional electrophoresis proteome. Blood Transfus. 2012;10 Suppl 2:s46-54 pubmed publisher
    ..Although AS-3 is based on a saline-adenine-glucose solution, it also contains citrate and phosphate...
  8. Sukrong S, Yun K, Stadler P, Kumar C, Facciuolo T, Moffatt B, et al. Improved growth and stress tolerance in the Arabidopsis oxt1 mutant triggered by altered adenine metabolism. Mol Plant. 2012;5:1310-32 pubmed publisher
    ..Oxt1 harbors a mutation that arises from the altered expression of a gene encoding adenine phosphoribosyltransferase (APT1), an enzyme that converts adenine to adenosine monophosphate (AMP), indicating a ..
  9. Naranbhai V, Abdool Karim S, Altfeld M, Samsunder N, Durgiah R, Sibeko S, et al. Innate immune activation enhances hiv acquisition in women, diminishing the effectiveness of tenofovir microbicide gel. J Infect Dis. 2012;206:993-1001 pubmed
    ..Hence, an innate immune activation suppressant could be added to tenofovir gel as a potential combination gel strategy in developing the next generation of higher efficacy antiretroviral microbicides. ..
  10. Baeten J, Donnell D, Ndase P, Mugo N, Campbell J, Wangisi J, et al. Antiretroviral prophylaxis for HIV prevention in heterosexual men and women. N Engl J Med. 2012;367:399-410 pubmed publisher
    ..Antiretroviral preexposure prophylaxis is a promising approach for preventing human immunodeficiency virus type 1 (HIV-1) infection in heterosexual populations...
  11. Zoutendijk R, Zaaijer H, de Vries Sluijs T, Reijnders J, Mulder J, Kroon F, et al. Hepatitis B surface antigen declines and clearance during long-term tenofovir therapy in patients coinfected with HBV and HIV. J Infect Dis. 2012;206:974-80 pubmed publisher
    ..Knowledge about the value of HBsAg levels in patients coinfected with HBV and human immunodeficiency virus (HIV) is lacking...
  12. Murphey Corb M, Rajakumar P, Michael H, Nyaundi J, Didier P, Reeve A, et al. Response of simian immunodeficiency virus to the novel nucleoside reverse transcriptase inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine in vitro and in vivo. Antimicrob Agents Chemother. 2012;56:4707-12 pubmed publisher
    ..These results suggest that expanded studies with EFdA are warranted. ..
  13. Lok A, Trinh H, Carosi G, Akarca U, Gadano A, Habersetzer F, et al. Efficacy of entecavir with or without tenofovir disoproxil fumarate for nucleos(t)ide-naïve patients with chronic hepatitis B. Gastroenterology. 2012;143:619-628.e1 pubmed publisher
    ..We compared the efficacy and safety of ETV monotherapy with those of a combination of ETV and TDF...
  14. Park H, Kim J, Park C. Activation of autophagy induces retinal ganglion cell death in a chronic hypertensive glaucoma model. Cell Death Dis. 2012;3:e290 pubmed publisher
    ..This may show that autophagy is differently regulated in different compartments of the neuron. This present study showed that autophgy is activated in RGCs and has a role in autophagic cell death after chronic IOP elevation...
  15. Scourfield A, Zheng J, Chinthapalli S, Waters L, Martin T, Mandalia S, et al. Discontinuation of Atripla as first-line therapy in HIV-1 infected individuals. AIDS. 2012;26:1399-401 pubmed publisher
    ..The commonest reason for switch in our cohort was CNS toxicity, which although it may develop shortly after initiation may persist, ultimately leading to discontinuation of Atripla months or years later. ..
  16. Guo X, Li D, Hu F, Song J, Zhang S, Deng W, et al. Targeting autophagy potentiates chemotherapy-induced apoptosis and proliferation inhibition in hepatocarcinoma cells. Cancer Lett. 2012;320:171-9 pubmed publisher
    ..This study suggests that autophagy is a potential novel target to improve therapy efficiency of conventional chemotherapeutics towards HCC. ..
  17. Young J, Schäfer J, Fux C, Furrer H, Bernasconi E, Vernazza P, et al. Renal function in patients with HIV starting therapy with tenofovir and either efavirenz, lopinavir or atazanavir. AIDS. 2012;26:567-75 pubmed publisher
    ..6 to 0.7) for each additional 6 months of therapy. Tenofovir with either boosted protease inhibitor leads to a greater initial decline in eGFR than tenofovir with efavirenz; this decline may be worse with ATV/r than with LPV/r. ..
  18. Clark M, Friend D. Pharmacokinetics and topical vaginal effects of two tenofovir gels in rabbits. AIDS Res Hum Retroviruses. 2012;28:1458-66 pubmed publisher
    ..These data indicate that the reduced-glycerin TFV 1% gel may be a suitable alternative to TFV 1% gel...