praziquantel

Summary

Summary: An anthelmintic used in most schistosome and many cestode infestations.

Top Publications

  1. Emukah E, Gutman J, Eguagie J, Miri E, Yinkore P, Okocha N, et al. Urine heme dipsticks are useful in monitoring the impact of praziquantel treatment on Schistosoma haematobium in sentinel communities of Delta State, Nigeria. Acta Trop. 2012;122:126-31 pubmed publisher
    ..To monitor the impact of annual mass drug administration (MDA) with Praziquantel for S...
  2. French M, Churcher T, Basanez M, Norton A, Lwambo N, Webster J. Reductions in genetic diversity of Schistosoma mansoni populations under chemotherapeutic pressure: the effect of sampling approach and parasite population definition. Acta Trop. 2013;128:196-205 pubmed publisher
    Detecting potential changes in genetic diversity in schistosome populations following chemotherapy with praziquantel (PZQ) is crucial if we are to fully understand the impact of such chemotherapy with respect to the potential emergence of ..
  3. Zou Q, Hu Y, Xue J, Fan X, Jin Y, Shi X, et al. Use of praziquantel as an adjuvant enhances protection and Tc-17 responses to killed H5N1 virus vaccine in mice. PLoS ONE. 2012;7:e34865 pubmed publisher
    ..Although the widely used killed vaccines are able to provide some protection against infection via neutralizing antibodies, cytotoxic T-lymphocyte responses that are thought to eradicate viral infections are lacking...
  4. Motta B, Schnyder M, Basano F, Nageli F, Nägeli C, Schiessl B, et al. Therapeutic efficacy of milbemycin oxime/praziquantel oral formulation (Milbemax®) against Thelazia callipaeda in naturally infested dogs and cats. Parasit Vectors. 2012;5:85 pubmed publisher
    ..The therapeutic efficacy of milbemycin oxime/praziquantel tablets (Milbemax®) against T. callipaeda was tested in naturally infested dogs and cats.
  5. Soukhathammavong P, Odermatt P, Sayasone S, Vonghachack Y, Vounatsou P, Hatz C, et al. Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, tribendimidine, and praziquantel in patients with Opisthorchis viverrini: a randomised, exploratory, open-label, phase 2 trial. Lancet Infect Dis. 2011;11:110-8 pubmed publisher
    b>Praziquantel is the only drug available for treatment of Opisthorchis viverrini, although in-vivo studies point to activity of mefloquine, artesunate, and tribendimidine against this liver fluke...
  6. Soliman M. Evaluation of avocado/soybean unsaponifiable alone or concurrently with praziquantel in murine schistosomiasis. Acta Trop. 2012;122:261-6 pubmed publisher
    ..to study the influence of administration of avocado/soybean unsaponifiable (ASU) alone or concurrently with praziquantel (PZQ) on Schistosoma mansoni-infected mice, this study was established...
  7. Reda E, Ouhtit A, Abdeen S, El Shabasy E. Structural changes of Schistosoma mansoni adult worms recovered from C57BL/6 mice treated with radiation-attenuated vaccine and/or praziquantel against infection. Parasitol Res. 2012;110:979-92 pubmed publisher
    Although the current treatment of schistosomiasis relies largely on praziquantel (PZQ), it has not significantly reduced the overall number of disease cases, perhaps due to inevitable resistance to PZQ...
  8. Betson M, Sousa Figueiredo J, Rowell C, Kabatereine N, Stothard J. Intestinal schistosomiasis in mothers and young children in Uganda: investigation of field-applicable markers of bowel morbidity. Am J Trop Med Hyg. 2010;83:1048-55 pubmed publisher
    ..0001) and mothers (n = 448, OR = 1.95, P = 0.004). Fecal occult blood appears to be useful for measuring morbidity associated with intestinal schistosomiasis and could be used in assessing the impact of control programs upon disease...
  9. Botros S, El Lakkany N, Seif El Din S, Sabra A, Ibrahim M. Comparative efficacy and bioavailability of different praziquantel brands. Exp Parasitol. 2011;127:515-21 pubmed publisher
    ..bioavailability and drug metabolizing enzymes mainly involved in the metabolism of the commercial brands of praziquantel (PZQ) in Egypt in comparison with the original pure powder...

Scientific Experts

More Information

Publications62

  1. Kim C, Lee J, Chung B, Li S, Choi M, Hong S. Influencing factors for cure of clonorchiasis by praziquantel therapy: infection burden and CYP3A5 gene polymorphism. Korean J Parasitol. 2011;49:45-9 pubmed publisher
    Chemotherapy of clonorchiasis with praziquantel (PZQ) is effective but about 15% of treated cases have been reported uncured...
  2. Charoensuk L, Pinlaor P, Prakobwong S, Hiraku Y, Laothong U, Ruangjirachuporn W, et al. Curcumin induces a nuclear factor-erythroid 2-related factor 2-driven response against oxidative and nitrative stress after praziquantel treatment in liver fluke-infected hamsters. Int J Parasitol. 2011;41:615-26 pubmed publisher
    b>Praziquantel has been used for the treatment of liver fluke infection, but an oxidative/nitrative stress may occur after a short-term treatment and participate in side effects...
  3. Zhu R, Gray D, Thrift A, Williams G, Zhang Y, Qiu D, et al. A 5-year longitudinal study of schistosomiasis transmission in Shian village, the Anning River Valley, Sichuan Province, the Peoples' Republic of China. Parasit Vectors. 2011;4:43 pubmed publisher
    ..Here we present the results from a schistosomiasis-endemic village located above the dam in Sichuan Province...
  4. Xie S, Pan B, Wang M, Zhu L, Wang F, Dong Z, et al. Formulation, characterization and pharmacokinetics of praziquantel-loaded hydrogenated castor oil solid lipid nanoparticles. Nanomedicine (Lond). 2010;5:693-701 pubmed publisher
    The purpose of this study was to formulate praziquantel (PZQ)-loaded hydrogenated castor oil (HCO) solid lipid nanoparticles (SLN) to enhance the bioavailability and prolong the systemic circulation of the drug...
  5. Sadhu P, Kumar S, Chandrasekharam M, Pica Mattoccia L, Cioli D, Rao V. Synthesis of new praziquantel analogues: potential candidates for the treatment of schistosomiasis. Bioorg Med Chem Lett. 2012;22:1103-6 pubmed publisher
    An efficient synthesis of antischistosomal drug praziquantel and analogues was achieved and the synthetic route designed was to afford structurally diverse analogues for better structure-activity relationship understanding...
  6. Zhang Z, Xu H, Gan W, Zeng S, Hu X. Schistosoma japonicum calcium-binding tegumental protein SjTP22.4 immunization confers praziquantel schistosomulumicide and antifecundity effect in mice. Vaccine. 2012;30:5141-50 pubmed publisher
    ..However, the SjTP22.4 immunized mice that received praziquantel treatment at 10d post infection caused 26% reduction in adult burden and 53% decrease in egg mature rate, ..
  7. Liang Y, Luo J, Yuan Q, Zheng D, Liu Y, Shi L, et al. New insight into the antifibrotic effects of praziquantel on mice in infection with Schistosoma japonicum. PLoS ONE. 2011;6:e20247 pubmed publisher
    ..The antifibrotic effects of praziquantel were assessed in the murine models of schistosomiasis japonica...
  8. Huang J, Bathena S, Alnouti Y. Metabolite profiling of praziquantel and its analogs during the analysis of in vitro metabolic stability using information-dependent acquisition on a hybrid triple quadrupole linear ion trap mass spectrometer. Drug Metab Pharmacokinet. 2010;25:487-99 pubmed
    ..simultaneous analysis of metabolic stability, metabolite profiling, and the kinetics of metabolite formation of praziquantel and three structural analogs...
  9. Seto E, Sousa Figueiredo J, Betson M, Byalero C, Kabatereine N, Stothard J. Patterns of intestinal schistosomiasis among mothers and young children from Lake Albert, Uganda: water contact and social networks inferred from wearable global positioning system dataloggers. Geospat Health. 2012;7:1-13 pubmed
    ..of a national control programme (NCP) in Uganda has led to routine treatment of intestinal schistosomiasis with praziquantel in the communities along Lake Albert...
  10. Ekpo U, Oluwole A, Abe E, Etta H, Olamiju F, Mafiana C. Schistosomiasis in infants and pre-school-aged children in sub-Saharan Africa: implication for control. Parasitology. 2012;139:835-41 pubmed publisher
    ..It is, therefore, necessary to review current policy of schistosomiasis control programmes in sub-Saharan Africa to consider the treatment of infant and pre-school-aged children and the health education to mothers...
  11. King C, Olbrych S, Soon M, Singer M, Carter J, Colley D. Utility of repeated praziquantel dosing in the treatment of schistosomiasis in high-risk communities in Africa: a systematic review. PLoS Negl Trop Dis. 2011;5:e1321 pubmed publisher
    ..In a systematic review of published studies, we examined evidence for incremental benefits from repeated praziquantel dosing, given 2 to 8 weeks after an initial dose, in Schistosoma-endemic areas of Africa.
  12. Conboy G, Bourque A, Miller L, Seewald W, Schenker R. Efficacy of Milbemax (milbemycin oxime + praziquantel) in the treatment of dogs experimentally infected with Crenosoma vulpis. Vet Parasitol. 2013;198:319-24 pubmed publisher
    ..The objective of this study was to determine the efficacy of milbemycin oxime (0.5mg/kg)/praziquantel (5mg/kg) (Milbemax; Novartis Animal Health, Inc.) against C...
  13. You H, McManus D, Hu W, Smout M, Brindley P, Gobert G. Transcriptional responses of in vivo praziquantel exposure in schistosomes identifies a functional role for calcium signalling pathway member CamKII. PLoS Pathog. 2013;9:e1003254 pubmed publisher
    Treatment for clinical schistosomiasis has relied centrally on the broad spectrum anthelmintic praziquantel; however, there is limited information on its mode of action or the molecular response of the parasite...
  14. Seto E, Wong B, Lu D, Zhong B. Human schistosomiasis resistance to praziquantel in China: should we be worried?. Am J Trop Med Hyg. 2011;85:74-82 pubmed publisher
    The efficacy of praziquantel for the treatment of Schistosoma japonicum in humans is reported from a cross-sectional survey conducted in 33 villages in Sichuan Province. Infection prevalence was found to be 5...
  15. Ahmed A, El Tash L, Mohamed E, Adam I. High levels of Schistosoma mansoni infections among schoolchildren in central Sudan one year after treatment with praziquantel. J Helminthol. 2012;86:228-32 pubmed publisher
    A longitudinal study was conducted to evaluate the impact of praziquantel (PZQ) for the treatment of Schistosoma mansoni infection among schoolchildren in Al Gunaid in Central Sudan...
  16. Stothard J, Sousa Figueiredo J, Betson M, Bustinduy A, Reinhard Rupp J. Schistosomiasis in African infants and preschool children: let them now be treated!. Trends Parasitol. 2013;29:197-205 pubmed publisher
    ..Despite mounting evidence showing that treatment with praziquantel is safe, beneficial, and could be delivered within ongoing public health interventions, young children still do ..
  17. Olliaro P, Vaillant M, Belizario V, Lwambo N, Ouldabdallahi M, Pieri O, et al. A multicentre randomized controlled trial of the efficacy and safety of single-dose praziquantel at 40 mg/kg vs. 60 mg/kg for treating intestinal schistosomiasis in the Philippines, Mauritania, Tanzania and Brazil. PLoS Negl Trop Dis. 2011;5:e1165 pubmed publisher
    b>Praziquantel at 40 mg/kg in a single dose is the WHO recommended treatment for all forms of schistosomiasis, but 60 mg/kg is also deployed nationally.
  18. Lovis L, Mak T, Phongluxa K, Ayé Soukhathammavong P, Vonghachack Y, Keiser J, et al. Efficacy of praziquantel against Schistosoma mekongi and Opisthorchis viverrini: a randomized, single-blinded dose-comparison trial. PLoS Negl Trop Dis. 2012;6:e1726 pubmed publisher
    Schistosomiasis and opisthorchiasis are of public health importance in Southeast Asia. Praziquantel (PZQ) is the drug of choice for morbidity control but few dose comparisons have been made.
  19. Stothard J, Sousa Figueiredo J, Betson M, Green H, Seto E, Garba A, et al. Closing the praziquantel treatment gap: new steps in epidemiological monitoring and control of schistosomiasis in African infants and preschool-aged children. Parasitology. 2011;138:1593-606 pubmed publisher
    ..and Schistosoma mansoni, is being formally explored as infected children are not presently targeted to receive praziquantel (PZQ) within current preventive chemotherapy campaigns...
  20. Mduluza T, Mutapi F, Ruwona T, Kaluka D, Midzi N, Ndhlovu P. Similar cellular responses after treatment with either praziquantel or oxamniquine in Schistosoma mansoni infection. Malawi Med J. 2009;21:176-82 pubmed
    The effect of treatment with either oxamniquine or praziquantel on S.mansoni specific IFN-gamma, IL-4, IL-5 and IL-10 was compared on PBMC which were collected pretreatment, 6 and 18 weeks post treatment...
  21. Wu W, Huang Y. Application of praziquantel in schistosomiasis japonica control strategies in China. Parasitol Res. 2013;112:909-15 pubmed publisher
    ..In 1960s, before praziquantel was developed, there were about seven million patients...
  22. Wang W, Li H, Qu G, Xing Y, Yang Z, Dai J, et al. Is there a reduced sensitivity of dihydroartemisinin against praziquantel-resistant Schistosoma japonicum?. Parasitol Res. 2014;113:223-8 pubmed publisher
    b>Praziquantel is currently the only drug of choice for the treatment of human schistosomiases. However, it has been proved that Schistosoma japonicum subjected to drug pressure may develop resistance to praziquantel...
  23. Wang W, Dai J, Li H, Shen X, Liang Y. Is there reduced susceptibility to praziquantel in Schistosoma japonicum? Evidence from China. Parasitology. 2010;137:1905-12 pubmed publisher
    b>Praziquantel is widely used for the treatment of human schistosomiasis. However, in recent years, there has been increasing concern about the resistance of Schistosoma species to praziquantel...
  24. Black C, Muok E, Mwinzi P, Carter J, Karanja D, Secor W, et al. Increases in levels of schistosome-specific immunoglobulin E and CD23(+) B cells in a cohort of Kenyan children undergoing repeated treatment and reinfection with Schistosoma mansoni. J Infect Dis. 2010;202:399-405 pubmed publisher
    ..children infected with Schistosoma mansoni develop protection-related immune responses after treatment with praziquantel and whether the development of these immune responses is accelerated by frequent treatment after reinfection...
  25. Kjetland E, Leutscher P, Ndhlovu P. A review of female genital schistosomiasis. Trends Parasitol. 2012;28:58-65 pubmed publisher
    ..Further research is needed to find simple, low-tech diagnostic methods, treatment for chronic lesions, and to explore the preventive effects of mass drug administration on symptoms, sandy patches, HPV and the HIV epidemic. ..
  26. Stete K, Krauth S, Coulibaly J, Knopp S, Hattendorf J, Müller I, et al. Dynamics of Schistosoma haematobium egg output and associated infection parameters following treatment with praziquantel in school-aged children. Parasit Vectors. 2012;5:298 pubmed publisher
    b>Praziquantel is the drug of choice in preventive chemotherapy targeting schistosomiasis. Increasing large-scale administration of praziquantel requires monitoring of drug efficacy to detect early signs of development of resistance...
  27. Garba A, Lamine M, Djibo A, Tahirou A, Aouami M, Alfari A, et al. Safety and efficacy of praziquantel syrup (Epiquantel®) against Schistosoma haematobium and Schistosoma mansoni in preschool-aged children in Niger. Acta Trop. 2013;128:318-25 pubmed publisher
    Given the characteristic age-prevalence curve of Schistosoma infection, preventive chemotherapy with praziquantel is primarily targeted at school-aged children, whilst, in highly endemic areas, other high-risk groups might be included for ..
  28. Ohnishi K, Sakamoto N, Kobayashi K, Iwabuchi S, Nakamura Uchiyama F. Therapeutic effect of praziquantel against Taeniasis asiatica. Int J Infect Dis. 2013;17:e656-7 pubmed publisher
    Eight Japanese adult patients infected with Taenia asiatica were treated with a single 600 mg dose of praziquantel. The patients' body weights ranged from 47 to 87 kg (mean 67.1±12.7 kg)...
  29. Kvaternick V, Kellermann M, Knaus M, Rehbein S, Rosentel J. Pharmacokinetics and metabolism of eprinomectin in cats when administered in a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel. Vet Parasitol. 2014;202:2-9 pubmed publisher
    ..3% (w/v), (S)-methoprene 10% (w/v), eprinomectin 0.4% (w/v) and praziquantel 8.3% (w/v)), delivering a dose of 0...
  30. Namwanje H, Kabatereine N, Olsen A. The acceptability and safety of praziquantel alone and in combination with mebendazole in the treatment of Schistosoma mansoni and soil-transmitted helminthiasis in children aged 1-4 years in Uganda. Parasitology. 2011;138:1586-92 pubmed publisher
    There is limited information on the acceptability and safety of praziquantel for treatment of schistosomiasis in children below the age of four years...
  31. Zou Q, Yao X, Feng J, Yin Z, Flavell R, Hu Y, et al. Praziquantel facilitates IFN-?-producing CD8+ T cells (Tc1) and IL-17-producing CD8+ T cells (Tc17) responses to DNA vaccination in mice. PLoS ONE. 2011;6:e25525 pubmed publisher
    ..Here, we report that praziquantel (PZQ), an anti-schistoma drug, could act as an adjuvant to overcome the lack of potent CTL responses by HBV DNA ..
  32. Woelfle M, Seerden J, de Gooijer J, Pouwer K, Olliaro P, Todd M. Resolution of praziquantel. PLoS Negl Trop Dis. 2011;5:e1260 pubmed publisher
    b>Praziquantel remains the drug of choice for the worldwide treatment and control of schistosomiasis. The drug is synthesized and administered as a racemate...
  33. Anto F, Asoala V, Anyorigiya T, Oduro A, Adjuik M, Akweongo P, et al. Simultaneous administration of praziquantel, ivermectin and albendazole, in a community in rural northern Ghana endemic for schistosomiasis, onchocerciasis and lymphatic filariasis. Trop Med Int Health. 2011;16:1112-9 pubmed publisher
    To compare (i) side effects associated with the simultaneous adminstration of praziquantel, albendazole and ivermectin with side affects associated with albendazole and ivermectin only and (ii) coverage by volunteers distributing three or ..
  34. Xiao S, Mei J, Jiao P. Effect of mefloquine administered orally at single, multiple, or combined with artemether, artesunate, or praziquantel in treatment of mice infected with Schistosoma japonicum. Parasitol Res. 2011;108:399-406 pubmed publisher
    ..of mefloquine administered orally at single, multiple doses, or in combination with artesuante, artemether, or praziquantel in mouse--Schistosoma japonicum model...
  35. Duan W, Qiu S, Zhao Y, Sun H, Qiao C, Xia C. Praziquantel derivatives exhibit activity against both juvenile and adult Schistosoma japonicum. Bioorg Med Chem Lett. 2012;22:1587-90 pubmed publisher
    A praziquantel analog 10-hydroxy praziquantel and eight praziquantel/peroxide conjugates were synthesized. The biological activity of these compounds was evaluated against juvenile and adult stages of Schistosoma japonicum...
  36. Namwanje H, Kabatereine N, Olsen A. A randomised controlled clinical trial on the safety of co-administration of albendazole, ivermectin and praziquantel in infected schoolchildren in Uganda. Trans R Soc Trop Med Hyg. 2011;105:181-8 pubmed publisher
    ..This study reports on the safety of a combination of albendazole, ivermectin and praziquantel in the treatment of lymphatic filariasis (LF), schistosomiasis and soil-transmitted helminthiasis (STH) in ..
  37. Navaratnam A, Sousa Figueiredo J, Stothard J, Kabatereine N, Fenwick A, Mutumba Nakalembe M. Efficacy of praziquantel syrup versus crushed praziquantel tablets in the treatment of intestinal schistosomiasis in Ugandan preschool children, with observation on compliance and safety. Trans R Soc Trop Med Hyg. 2012;106:400-7 pubmed publisher
    ..aged ?5 years) have so far been overlooked by mass treatment campaigns targeting schistosomiasis, even though praziquantel (PZQ) has been shown to be well tolerated and effective within this age group...
  38. Patra M, Ingram K, Leonidova A, Pierroz V, Ferrari S, Robertson M, et al. In vitro metabolic profile and in vivo antischistosomal activity studies of (?(6)-praziquantel)Cr(CO)3 derivatives. J Med Chem. 2013;56:9192-8 pubmed publisher
    ..vitro metabolic behavior was investigated for two chromium tricarbonyl derivatives of the antischistosomal drug praziquantel (PZQ) with the formula (?(6)-PZQ)Cr(CO)3 (1 and 2), by use of human liver microsomes...
  39. Hodges M, Paye J, Koroma M, Nyorkor E, Fofonah I, Zhang Y. High level of Schistosoma mansoni infection in pre-school children in Sierra Leone highlights the need in targeting this age group for praziquantel treatment. Acta Trop. 2012;124:120-5 pubmed publisher
    ..The national control program currently does not target this group of children for schistosomiasis, while mass drug administration (MDA) has been performed six monthly for STHs in children 12-59 months of age since 2006...
  40. Koroma J, Peterson J, Gbakima A, Nylander F, Sahr F, Soares Magalhaes R, et al. Geographical distribution of intestinal schistosomiasis and soil-transmitted helminthiasis and preventive chemotherapy strategies in Sierra Leone. PLoS Negl Trop Dis. 2010;4:e891 pubmed publisher
  41. Qian C, Song L, Hua W, Yin X, Wang J, Zhang W, et al. Kinetics of circulating antigen 14-3-3 in sera of rabbits firstly infected with Schistosoma japonicum and treated with/without praziquantel. Parasitol Res. 2011;108:493-5 pubmed publisher
    ..The 14-3-3 levels in the sera significantly decreased after the infected rabbits were treated with praziquantel at 6 weeks postinfection and declined to the initial level about 8 weeks posttreatment...
  42. Sousa Figueiredo J, Day M, Betson M, Kabatereine N, Stothard J. An inclusive dose pole for treatment of schistosomiasis in infants and preschool children with praziquantel. Trans R Soc Trop Med Hyg. 2010;104:740-2 pubmed publisher
    ..for control of schistosomiasis, use of the WHO dose pole is favoured for mass drug administration of praziquantel. Application of this simple tool has enabled pragmatic tablet dosing using patient height as a proxy for ..
  43. Gryseels B. Schistosomiasis. Infect Dis Clin North Am. 2012;26:383-97 pubmed publisher
    ..b>Praziquantel is the drug of choice, active against all species in a single or a few oral doses...
  44. Xie S, Pan B, Shi B, Zhang Z, Zhang X, Wang M, et al. Solid lipid nanoparticle suspension enhanced the therapeutic efficacy of praziquantel against tapeworm. Int J Nanomedicine. 2011;6:2367-74 pubmed publisher
    ..In order to enhance the therapeutic efficacy of praziquantel (PZQ) against tapeworm, PZQ-loaded hydrogenated castor oil solid lipid nanoparticle (PZQ-HCO-SLN) suspension ..
  45. Shaw J, Aggarwal N, Acosta L, Jiz M, Wu H, Leenstra T, et al. Reduction in hookworm infection after praziquantel treatment among children and young adults in Leyte, the Philippines. Am J Trop Med Hyg. 2010;83:416-21 pubmed publisher
    One small previous study found that praziquantel reduced hookworm infection. In this study, 607 subjects were enrolled in a longitudinal study...
  46. Sohn W, Chai J, Yong T, Eom K, Yoon C, Sinuon M, et al. Echinostoma revolutum infection in children, Pursat Province, Cambodia. Emerg Infect Dis. 2011;17:117-9 pubmed publisher
    ..The prevalence of infection with echinostome flukes ranged from 7.5% to 22.4% in 4 schools surveyed. Adult worms were identified as Echinostoma revolutum...
  47. Crosby A, Jones F, Kolosionek E, Southwood M, Purvis I, Soon E, et al. Praziquantel reverses pulmonary hypertension and vascular remodeling in murine schistosomiasis. Am J Respir Crit Care Med. 2011;184:467-73 pubmed publisher
    Schistosomiasis is the most common worldwide cause of pulmonary arterial hypertension. The anti-schistosome drug praziquantel has been shown to reverse the liver fibrosis associated with Schistosoma mansoni in mice...
  48. Adoubryn K, Kouadio Yapo C, Ouhon J, Aka N, Bintto F, Assoumou A. [Intestinal parasites in children in Biankouma, Ivory Coast (mountaineous western region): efficacy and safety of praziquantel and albendazole]. Med Sante Trop. 2012;22:170-6 pubmed publisher
    ..prevalences of intestinal helminth infection and to assess the clinical efficacy, tolerance, and safety of praziquantel and albendazole for treating it...
  49. Sousa Figueiredo J, Betson M, Atuhaire A, Arinaitwe M, Navaratnam A, Kabatereine N, et al. Performance and safety of praziquantel for treatment of intestinal schistosomiasis in infants and preschool children. PLoS Negl Trop Dis. 2012;6:e1864 pubmed publisher
    ..that infants and preschool children are at significant risk of schistosomiasis and qualify for treatment with praziquantel (PZQ)...
  50. Garba A, Lamine M, Barkiré N, Djibo A, Sofo B, Gouvras A, et al. Efficacy and safety of two closely spaced doses of praziquantel against Schistosoma haematobium and S. mansoni and re-infection patterns in school-aged children in Niger. Acta Trop. 2013;128:334-44 pubmed publisher
    The aim of this study was to assess the efficacy and safety of two closely spaced doses of praziquantel (PZQ) against Schistosoma haematobium and S...
  51. Lima R, Ferreira M, De Jesus Ponte Carvalho T, Dumêt Fernandes B, Takayanagui O, Garcia H, et al. Albendazole-praziquantel interaction in healthy volunteers: kinetic disposition, metabolism and enantioselectivity. Br J Clin Pharmacol. 2011;71:528-35 pubmed publisher
    This study investigated the kinetic disposition, metabolism and enantioselectivity of albendazole (ABZ) and praziquantel (PZQ) administered alone and in combination to healthy volunteers.
  52. El Lakkany N, El Maadawy W, Ain Shoka A, Badawy A, Hammam O, Ebeid F. Potential antifibrotic effects of AT1 receptor antagonist, losartan, and/or praziquantel on acute and chronic experimental liver fibrosis induced by Schistosoma mansoni. Clin Exp Pharmacol Physiol. 2011;38:695-704 pubmed publisher
    1. This study investigates the potential antifibrotic effect of losartan, AT-1 receptor antagonist, and/or praziquantel (PZQ) on acute and chronic hepatic fibrosis induced by Schistosoma mansoni (S. mansoni). 2...
  53. Liu R, Dong H, Guo Y, Zhao Q, Jiang M. Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: a systematic review and meta-analysis. Parasit Vectors. 2011;4:201 pubmed publisher
    b>Praziquantel has been used as first-line drug for chemotherapy of schistosomiasis since 1984. Besides praziquantel, artemether and artesunate have also been used for the control of this infectious disease since late 1990s...