captan

Summary

Summary: One of the phthalimide fungicides.

Top Publications

  1. Angioni A, Garau V, Aguilera Del Real A, Melis M, Minelli E, Tuberoso C, et al. GC-ITMS determination and degradation of captan during winemaking. J Agric Food Chem. 2003;51:6761-6 pubmed
    b>Captan and its metabolite tetrahydrophthalimide (THPI) were determined in grapes, must, and wine by GC-ITMS. Pesticides were extracted with acetone/petroleum ether (50:50 v/v)...
  2. Suzuki T, Nojiri H, Isono H, Ochi T. Oxidative damages in isolated rat hepatocytes treated with the organochlorine fungicides captan, dichlofluanid and chlorothalonil. Toxicology. 2004;204:97-107 pubmed
    The cytotoxicity and lipid peroxidative potency of the organochlorine fungicides captan (N-(trichloromethylthio)-4-cyclohexene-1,2-dicarboximide), dichlofluanid (N-dichlorofluoromethylthio-N'N'-dimethyl-N-phenylsulfamide) and ..
  3. Phalen R, Hee S. A moving robotic hand system for whole-glove permeation and penetration: captan and nitrile gloves. J Occup Environ Hyg. 2008;5:258-70 pubmed publisher
    ..this study was to develop a robotic hand to test the influence of hand movement on the permeation/penetration of captan through disposable nitrile rubber gloves...
  4. Arce G, Gordon E, Cohen S, Singh P. Genetic toxicology of folpet and captan. Crit Rev Toxicol. 2010;40:546-74 pubmed publisher
    Folpet and captan are fungicides whose genotoxicity depends on their chemical reaction with thiols...
  5. Everich R, Schiller C, Whitehead J, Beavers M, Barrett K. Effects of captan on Apis mellifera brood development under field conditions in California almond orchards. J Econ Entomol. 2009;102:20-9 pubmed
    ..County) and northern (Yolo County) California to evaluate the potential effects of commercial applications of Captan on honey bees, Apis mellifera L. Captan was applied at 5.0 kg (AI)/ha during bloom...
  6. Greenburg D, Rusiecki J, Koutros S, Dosemeci M, Patel R, Hines C, et al. Cancer incidence among pesticide applicators exposed to captan in the Agricultural Health Study. Cancer Causes Control. 2008;19:1401-7 pubmed publisher
    b>Captan is a widely used antifungal pesticide whose potential to cause cancer in humans is uncertain. We evaluated the incidence of cancer among pesticide applicators exposed to captan in the Agricultural Health Study...
  7. Hines C, Deddens J, Jaycox L, Andrews R, Striley C, Alavanja M. Captan exposure and evaluation of a pesticide exposure algorithm among orchard pesticide applicators in the Agricultural Health Study. Ann Occup Hyg. 2008;52:153-66 pubmed publisher
    ..We evaluated this algorithm using actual fungicide exposure measurements from AHS private orchard applicators. Captan was selected as a marker of fungicide exposure...
  8. Heredia Ortiz R, Bouchard M. Toxicokinetic modeling of captan fungicide and its tetrahydrophthalimide biomarker of exposure in humans. Toxicol Lett. 2012;213:27-34 pubmed publisher
    ..of tetrahydrophthalimide (THPI) in urine has been used for the biomonitoring of exposure to the widely used captan fungicide in workers...
  9. Gordon E. Captan: transition from 'B2' to 'not likely'. How pesticide registrants affected the EPA Cancer Classification Update. J Appl Toxicol. 2007;27:519-26 pubmed
    On 24 November 2004 EPA changed the cancer classification of captan from a 'probable human carcinogen' (Category B2) to 'not likely' when used according to label directions...

More Information

Publications62

  1. Hines C, Deddens J, Coble J, Kamel F, Alavanja M. Determinants of captan air and dermal exposures among orchard pesticide applicators in the Agricultural Health Study. Ann Occup Hyg. 2011;55:620-33 pubmed publisher
    To identify and quantify determinants of captan exposure among 74 private orchard pesticide applicators in the Agricultural Health Study (AHS)...
  2. Hughes E, Zalts A, Ojeda J, Flores A, Glass R, Montserrat J. Analytical method for assessing potential dermal exposure to captan, using whole body dosimetry, in small vegetable production units in Argentina. Pest Manag Sci. 2006;62:811-8 pubmed
    ..has been developed that can be used to determine the potential dermal exposure (PDE) of workers to the pesticide captan in small-scale horticultural production units...
  3. Choi J, Kim Y, Song S, Lee I, Lee W. Optical biosensor consisting of glutathione-S-transferase for detection of captan. Biosens Bioelectron. 2003;18:1461-6 pubmed
    The optical biosensor consisting of a glutathione-S-transferase (GST)-immobilized gel film was developed to detect captan in contaminated water...
  4. Nazir A, Mukhopadhyay I, Saxena D, Siddiqui M, Chowdhuri D. Evaluation of toxic potential of captan: Induction of hsp70 and tissue damage in transgenic Drosophila melanogaster (hsp70-lacZ) Bg9. J Biochem Mol Toxicol. 2003;17:98-107 pubmed
    The study investigated the working hypothesis that a widely used fungicide captan exerts toxic effects on nontarget organisms...
  5. Lebailly P, Devaux A, Pottier D, De Meo M, Andre V, Baldi I, et al. Urine mutagenicity and lymphocyte DNA damage in fruit growers occupationally exposed to the fungicide captan. Occup Environ Med. 2003;60:910-7 pubmed
    ..leucocytes of farmers before and after a one-day spraying period of pear and apple trees with the fungicide captan in usual conditions...
  6. Kennedy M. Bayesian modelling of long-term dietary intakes from multiple sources. Food Chem Toxicol. 2010;48:250-63 pubmed publisher
    ..based on consumption data for UK children, considering the distribution of daily intakes of pyrimethanil, captan and chlorpyrifos aggregated over 4, 6 and 10 food types, respectively...
  7. Ohta T, Tokishita S, Tsunoi R, Ohmae S, Yamagata H. Characterization of Trp(+) reversions in Escherichia coli strain WP2uvrA. Mutagenesis. 2002;17:313-6 pubmed
    ..C-->A.T and G.C-->T.A. About 30-50% of Trp(+) revertants induced by N-ethyl-N'-nitro-N-nitrosoguanidine, captan and angelicin plus UVA irradiation were attributable to reversion at the trpE65 ochre locus; the others were ..
  8. Garcia G J, Kirchhoff J, Grossmann F. [Behavior of captafol residues after prolonged application in a wheat monoculture]. J Environ Sci Health B. 1990;25:185-204 pubmed
    ..After a 9-year application of captafol, there was no evidence of an enrichment of residues in the soil. At harvest, captafol residues in grains always were below the maximum residue limits of 0.5 mg/kg established in West Germany. ..
  9. Slager R, Simpson S, LeVan T, Poole J, Sandler D, Hoppin J. Rhinitis associated with pesticide use among private pesticide applicators in the agricultural health study. J Toxicol Environ Health A. 2010;73:1382-93 pubmed publisher
    ..23, 95% CI = 1.09-1.38). The fungicide captan was also a significant predictor of rhinitis...
  10. Xu X, Murray R, Salazar J, Hyder K. The temporal pattern of captan residues on apple leaves and fruit under field conditions in relation to weather and canopy structure. Pest Manag Sci. 2008;64:565-78 pubmed publisher
    b>Captan is an important fungicide for controlling diseases in horticultural crops. Understanding its dissipation is important for estimating dietary risks and optimising pesticide application...
  11. Pahwa P, Karunanayake C, Dosman J, Spinelli J, McDuffie H, McLaughlin J. Multiple myeloma and exposure to pesticides: a Canadian case-control study. J Agromedicine. 2012;17:40-50 pubmed publisher
    ..90 (1.11, 3.27) adjusted for potential confounders]. An exposure to fungicide captan [2.35 (1.03, 5.35)] was positively associated with the incidence of multiple myeloma...
  12. Singh A, Chhatpar H. Purification and characterization of chitinase from Paenibacillus sp. D1. Appl Biochem Biotechnol. 2011;164:77-88 pubmed publisher
    ..The enzyme exhibited higher stability in presence of commonly used protectant fungicides Captan, Carbendazim, and Mancozeb compared to control as reflected from the t (1/2) values suggesting its applicability ..
  13. Chen K, Mackie J, Kennedy E, Dlugogorski B. Air pollutants formed in thermal decomposition of folpet fungicide under oxidative conditions. Environ Sci Technol. 2011;45:554-60 pubmed publisher
    ..the decomposition of folpet fungicide under oxidative conditions and compares the product species with those of captan fungicide, which is structurally related to folpet...
  14. Wedge D, Nagle D. A new 2D-TLC bioautography method for the discovery of novel antifungal agents To control plant pathogens. J Nat Prod. 2000;63:1050-4 pubmed
    ..Mixtures of structurally diverse antifungal agents were tested to establish the validity and utility of this method in the discovery of new natural products with activity against agriculturally important fungal pathogens...
  15. Zentai A, Sali J, Szabo I, Szeitzne Szabo M, Ambrus A, Vasarhelyi A. Factors affecting the estimated probabilistic acute dietary exposure to captan from apple consumption. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30:833-42 pubmed publisher
    ..The 4720 daily apple consumption data and the results of 1239 apple sample analyses for captan residues, performed within the Hungarian monitoring programme between 2005 and 2011, were used in this study as ..
  16. Garcia G, Kirchhoff J, Grossmann F. [Formation and degradation of triademinol after the use of triadimefon in a wheat monoculture]. J Environ Sci Health B. 1991;26:427-36 pubmed
    ..Triadimenol-A predominated in the two uppermost leaves, and triadimenol-B in the roots and in the soil. No residues of triadimenol were found in grain at harvest time (detection limit 0.01 mg/kg). ..
  17. Berthet A, Heredia Ortiz R, Vernez D, Danuser B, Bouchard M. A detailed urinary excretion time course study of captan and folpet biomarkers in workers for the estimation of dose, main route-of-entry and most appropriate sampling and analysis strategies. Ann Occup Hyg. 2012;56:815-28 pubmed publisher
    b>Captan and folpet are two fungicides largely used in agriculture, but biomonitoring data are mostly limited to measurements of captan metabolite concentrations in spot urine samples of workers, which complicate interpretation of results ..
  18. Gaind S, Rathi M, Kaushik B, Nain L, Verma O. Survival of bio-inoculants on fungicides-treated seeds of wheat, pea and chickpea and subsequent effect on chickpea yield. J Environ Sci Health B. 2007;42:663-8 pubmed
    ..of Azotobacter chroococcum (W(5)) was also examined on wheat (Triticum aestivum) seeds treated with bavistin, captan (cis-N-trichloromethyl thio-4 cyclohexane-1, 2-dicarboximide) and thiram under laboratory conditions using ..
  19. Berthet A, Bouchard M, Vernez D. Toxicokinetics of captan and folpet biomarkers in dermally exposed volunteers. J Appl Toxicol. 2012;32:202-9 pubmed publisher
    To better assess biomonitoring data in workers exposed to captan and folpet, the kinetics of ring metabolites [tetrahydrophthalimide (THPI), phthalimide (PI) and phthalic acid] were determined in urine and plasma of dermally exposed ..
  20. Barreda M, Lopez F, Villarroya M, Beltran J, García Baudín J, Hernandez F. Residue determination of captan and folpet in vegetable samples by gas chromatography/negative chemical ionization-mass spectrometry. J AOAC Int. 2006;89:1080-7 pubmed
    ..spectrometry (GC/NCI-MS) method has been developed for the simultaneous determination of the fungicides captan and folpet in khaki (persimmon; flesh and peel) and cauliflower...
  21. Sadło S, Duda M, Piechowicz B, Jazwa A. Comparative study on disappearance trends of captan and trifloxystrobin residues on fruit and apple tree leaves using internal normalisation method. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30:826-32 pubmed publisher
    ..b>Captan and trifloxystrobin residues were determined with the use of gas chromatograph equipped with a micro-electron ..
  22. Vrijman C, Hosseinpour D, Bakker J, Wolkerstorfer A, Bos J, van der Veen J, et al. Provoking factors, including chemicals, in Dutch patients with vitiligo. Br J Dermatol. 2013;168:1003-11 pubmed publisher
    ..The chemicals involved were para-tertiary butylphenol (n = 2), captan (n = 1) and diphencyprone (n = 1)...
  23. Galeano T, Guiberteau A, Mora N, Alvarez P, Salinas F. Spectrophotometric determination of the fungicide captan. J Environ Sci Health B. 2002;37:533-40 pubmed
    A spectrophotometric method for the determination of the fungicide captan has been developed based on its reaction with thiosemicarbazide. The absorbance was measured at 315 nm...
  24. Bildfell R, Hedstrom O, Dearing P. Outbreak of dermatophytosis in farmed mink in the USA. Vet Rec. 2004;155:746-8 pubmed
  25. Nesakumar N, Ramachandra B, Sethuraman S, Krishnan U, Rayappan J. Evaluation of Inhibition Efficiency for the Detection of Captan, 2,3,7,8-Tetrachlorodibenzodioxin, Pentachlorophenol and Carbosulfan in Water: An Electrochemical Approach. Bull Environ Contam Toxicol. 2016;96:217-23 pubmed publisher
    ..method has been devised based on the change in catalytic activity of acetylcholinesterase (AChE) enzyme induced by captan, carbosulfan, 2,3,7,8-tetrachlorodibenzodioxin (TCDD) and pentachlorophenol (PCP) for the investigation of ..
  26. Megadi V, Tallur P, Mulla S, Ninnekar H. Bacterial degradation of fungicide captan. J Agric Food Chem. 2010;58:12863-8 pubmed publisher
    The phthalimide fungicide captan has been widely used to control plant pathogenic fungi. A strain of Bacillus circulans utilized the fungicide captan as sole source of carbon and energy...
  27. Imanzadeh G, Ahmadi F, Zamanloo M, Mansoori Y. Tetrabutylammonium bromide media aza-Michael addition of 1,2,3,6-tetrahydrophthalimide to symmetrical fumaric esters and acrylic esters under solvent-free conditions. Molecules. 2010;15:7353-62 pubmed publisher
    ..Although the reaction was also applicable to acrylates such as n-butyl acrylate, methacrylates and crotonates were not suitable Michael acceptors for this reaction. ..
  28. Ghillebaert F, Chaillou C, Deschamps F, Roubaud P. Toxic effects, at three pH levels, of two reference molecules on common carp embryo. Ecotoxicol Environ Saf. 1995;32:19-28 pubmed
    ..The toxicological interpretation of these results is discussed. They confirm the need of multifactorial methods for toxic risks and effects assessment on fish early life stages in the environment. ..
  29. Nagayama T, Takano I, Kobayashi M, Tamura Y, Tomizawa S, Tateishi Y, et al. [Determination of captafol, cyhexatin, 1-naphthylacetic acid and quintozene in apple, Japanese pear and melon by simultaneous extraction]. Shokuhin Eiseigaku Zasshi. 2003;44:126-31 pubmed
    ..2 ng per injection, which corresponds to a detection limit of below 0.02 microgram/g in the original samples. Recoveries of the pesticides spiked at 0.1 microgram/g into apple, Japanese pear and melon were greater than 61%...
  30. Phalen R, Que Hee S. Permeation of captan through disposable nitrile glove. J Hazard Mater. 2003;100:95-107 pubmed
    The purpose of this study was to investigate the permeation of an aqueous emulsion of the pesticide, captan, as a wettable powder (48...
  31. Podbielska M, Szpyrka E, Piechowicz B, Zwolak A, Sadło S. Behavior of fluopyram and tebuconazole and some selected pesticides in ripe apples and consumer exposure assessment in the applied crop protection framework. Environ Monit Assess. 2017;189:350 pubmed publisher
    ..were an attempt to determine a model for dissipation and toxicological evaluation of fluopyram, tebuconazole, captan, tetrahydrophthalimide (THPI), pirimicarb, spirodiclofen, and boscalid residues detected in fruit of Red ..
  32. Tripathi G. Relative toxicity of aldrin, fenvalerate, captan and diazinon to the freshwater food-fish, Clarias batrachus. Biomed Environ Sci. 1992;5:33-8 pubmed
    The median lethal concentrations (LC50S) of aldrin, fenvalerate, captan and diazinon were determined for Clarias batrachus by trimmed Spearman-Karber method...
  33. Boran H, Capkin E, Altinok I, Terzi E. Assessment of acute toxicity and histopathology of the fungicide captan in rainbow trout. Exp Toxicol Pathol. 2012;64:175-9 pubmed publisher
    Acute toxicity of the fungicide, captan, to juvenile rainbow trout was evaluated under static-renewal test condition. Actual concentrations of captan ranged from 0.05 to 1.00 mg/L...
  34. Klimek B. Effect of long-term zinc pollution on soil microbial community resistance to repeated contamination. Bull Environ Contam Toxicol. 2012;88:617-22 pubmed publisher
    ..500, 1,500 and 4,500 mg kg(-1) soil dw), and then a bactericide (oxytetracycline) combined with a fungicide (captan) along with glucose (10 mg g(-1) soil dw each) were added...
  35. Dalvi R. Involvement of glutathione in the reduction of captan-induced in vivo inhibition of monooxygenases and liver toxicity in the rat. J Environ Sci Health B. 1988;23:171-8 pubmed
    If given orally captan is relatively nontoxic, but it can be extremely toxic after parenteral exposure. Therefore, a single i.p...
  36. Zang X, Wang J, Wang O, Wang M, Ma J, Xi G, et al. Analysis of captan, folpet, and captafol in apples by dispersive liquid-liquid microextraction combined with gas chromatography. Anal Bioanal Chem. 2008;392:749-54 pubmed publisher
    A novel method was developed for the determination of captan, folpet, and captafol in apples by dispersive liquid-liquid microextraction (DLLME) coupled with gas chromatography-electron capture detection (GC-ECD)...
  37. Wu C, Chiu H. Rapid method for determining dermal exposures to pesticides by use of tape stripping and FTIR spectroscopy: a pilot study. J Occup Environ Hyg. 2007;4:952-8 pubmed
    ..e., chlorpyrifos, a commonly used pesticide) and a mixture of two chemicals (i.e., chlorpyrifos and captan); these were analyzed with or without the human stratum corneum in the samples...
  38. Paolini M, Barillari J, Trespidi S, Valgimigli L, Pedulli G, Cantelli Forti G. Captan impairs CYP-catalyzed drug metabolism in the mouse. Chem Biol Interact. 1999;123:149-70 pubmed
    To investigate whether the fungicide captan impairs CYP-catalyzed drug metabolism in murine liver, kidney and lung, the modulation of the regio- and stereo-selective hydroxylation of testosterone, including 6beta-(CYP3A), 6alpha-(CYP2A1 ..
  39. Guiberteau A, Galeano T, Mora N, Salinas F, Ortiz J, Vire J. Resolution by polarographic techniques of the ternary mixture of captan, captafol and folpet by using PLS calibration and artificial neuronal networks. Comput Chem. 2001;25:459-73 pubmed
    The simultaneous polarographic determination of the ternary mixture of captan-captafol and folpet is studied. The polarographic signals of these compounds in their mixture show a high overlapping...
  40. Schoofs H, Vandebroek K, Pierrard A, Thonart P, Lepoivre P, Beaudry T, et al. Bacteriocin Serratine-P as a biological tool in the control of fire blight Erwinia amylovora. Meded Rijksuniv Gent Fak Landbouwkd Toegep Biol Wet. 2002;67:361-8 pubmed
    ..In this paper some trials are discussed on the use of Serratine-P at different doses and on different infection types on pear trees. The results indicate interesting protection possibilities on blossom- and fruit infections. ..
  41. Chodorowski Z, Anand J. Acute oral suicidal intoxication with Captan--a case report. J Toxicol Clin Toxicol. 2003;41:603 pubmed
  42. Fernandez Cruz M, Grimalt S, Villarroya M, Lopez F, Llanos S, Garcia Baudin J. Residue levels of captan and trichlorfon in field-treated kaki fruits, individual versus composite samples, and after household processing. Food Addit Contam. 2006;23:591-600 pubmed
    The dissipation of residue levels of captan and trichlorfon in field-treated kaki crops was studied according to good laboratory practices to propose maximum residue limits (MRLs)...
  43. Saxena S, Ashok B, Musarrat J. Mutagenic and genotoxic activities of four pesticides: captan, foltaf, phosphamidon and furadan. Biochem Mol Biol Int. 1997;41:1125-36 pubmed
    The mutagenic and genotoxic potential of four pesticides viz. captan, foltaf, phosphamidon and furadan was evaluated by the Ames mutagenicity assay and their DNA damaging ability on radiation repair defective E...
  44. Rademaker M. Occupational contact dermatitis among New Zealand farmers. Australas J Dermatol. 1998;39:164-7 pubmed
  45. Rahden Staron I. The inhibitory effect of the fungicides captan and captafol on eukaryotic topoisomerases in vitro and lack of recombinagenic activity in the wing spot test of Drosophila melanogaster. Mutat Res. 2002;518:205-13 pubmed
    In studies on the mechanisms of mutagenic and carcinogenic action of captan and captafol-related chloroalkylthiocarboximide fungicides, two effects were tested: (i) the effect of both compounds on the activity of eukaryotic topoisomerases ..
  46. Galea K, MacCalman L, Jones K, Cocker J, Teedon P, Sleeuwenhoek A, et al. Biological monitoring of pesticide exposures in residents living near agricultural land. BMC Public Health. 2011;11:856 pubmed publisher
    ..Therefore, this study aims to collect measurements to determine if the current methods and tools are appropriate for assessing pesticide exposure for residents living near agricultural fields...
  47. Chen K, Mackie J, Kennedy E, Dlugogorski B. Thermal decomposition of captan and formation pathways of toxic air pollutants. Environ Sci Technol. 2010;44:4149-54 pubmed publisher
    This study investigates the thermal decomposition of a widely used fungicide, captan, under gas phase conditions, similar to those occurring in fires, cigarette burning, and combustion of biomass treated or contaminated with pesticides...
  48. Altinok I, Capkin E, Boran H. Influence of bioassay volume, water column height, and octanol-water partition coefficient on the toxicity of pesticides to rainbow trout. Bull Environ Contam Toxicol. 2011;86:596-600 pubmed publisher
    ..of water volume and water column height on toxicity of cypermethrin, carbaryl, dichlorvos, tetradifon, maneb, captan, carbosulfan endosulfan and HgCl? to juvenile rainbow trout (Oncorhynchus mykiss, 3.2 ± 0...
  49. Huo R, Salazar J, Hyder K, Xu X. Modelling non-systemic pesticide residues in fruits with initial deposit variability and weather effects. Food Addit Contam. 2007;24:1257-67 pubmed
    ..For the purpose of evaluation, this model was parameterized specifically for captan, one of the most important non-systemic fungicides used to control disease in horticultural crops...
  50. Thobunluepop P, Pawelzik E, Vearasilp S. The perspective effects of various seed coating substances on rice seed variety Khao DAWK Mali 105 storability I: the case study of physiological properties. Pak J Biol Sci. 2008;11:2291-9 pubmed
    ..KDML 105 which were coated with various seed coating substances [chemical fungicide, captan (CA) and biological coating polymers; chitosan-lignosulphonate polymer (CL) and eugenol incorporated into chitosan-..
  51. Krishnamurthy Y, Shashikala J. Inhibition of aflatoxin B production of Aspergillus flavus, isolated from soybean seeds by certain natural plant products. Lett Appl Microbiol. 2006;43:469-74 pubmed
    The inhibitory effect of cowdung fumes, Captan, leaf powder of Withania somnifera, Hyptis suaveolens, Eucalyptus citriodora, peel powder of Citrus sinensis, Citrus medica and Punica granatum, neem cake and pongamia cake and spore ..
  52. Ahmad M, Javed F, Ashraf M, Hafeez F. Effect of fungicide seed treatments on N2-fixation and nodulation in pea, Pisum sativum L. Bull Environ Contam Toxicol. 2006;77:896-904 pubmed
  53. Phalen R, Que Hee S. Variability in surface infrared reflectance of thirteen nitrile rubber gloves at key wavelengths for analysis of captan. Appl Spectrosc. 2007;61:204-11 pubmed
    ..total reflection Fourier transform infrared (ATR-FT-IR) spectrophotometry at key wavelengths for analysis of captan contamination...