perindopril

Summary

Summary: An angiotensin-converting enzyme inhibitor. It is used in patients with hypertension and heart failure.

Top Publications

  1. Beckett N, Peters R, Fletcher A, Staessen J, Liu L, Dumitrascu D, et al. Treatment of hypertension in patients 80 years of age or older. N Engl J Med. 2008;358:1887-98 pubmed publisher
    ..5 mg) or matching placebo. The angiotensin-converting-enzyme inhibitor perindopril (2 or 4 mg), or matching placebo, was added if necessary to achieve the target blood pressure of 150/80 mm Hg...
  2. Dahlof B, Sever P, Poulter N, Wedel H, Beevers D, Caulfield M, et al. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (AS. Lancet. 2005;366:895-906 pubmed
    ..myocardial infarction and fatal CHD of combinations of atenolol with a thiazide versus amlodipine with perindopril. We did a multicentre, prospective, randomised controlled trial in 19 257 patients with hypertension who were ..
  3. Cleland J, Tendera M, Adamus J, Freemantle N, Polonski L, Taylor J. The perindopril in elderly people with chronic heart failure (PEP-CHF) study. Eur Heart J. 2006;27:2338-45 pubmed
    ..This was a randomized double-blind trial, comparing placebo with perindopril, 4 mg/day in patients aged > or =70 years with a diagnosis of heart failure, treated with diuretics and an ..
  4. Holzgreve H, Risler T, Trenkwalder P. Efficacy and tolerability of the perindopril/indapamide combination therapy for hypertension: the PRIMUS study. Curr Med Res Opin. 2006;22:1849-58 pubmed
    ..To evaluate the efficacy and tolerability of the first line combination perindopril/indapamide in hypertension in daily practice...
  5. Ferrari R. Optimizing the treatment of hypertension and stable coronary artery disease: clinical evidence for fixed-combination perindopril/amlodipine. Curr Med Res Opin. 2008;24:3543-57 pubmed
    ..This article reviews evidence for the fixed combination of the angiotensin-converting enzyme (ACE) inhibitor perindopril and the calcium channel blocker amlodipine...
  6. Minami N, Li Y, Guo Q, Kawamura T, Mori N, Nagasaka M, et al. Effects of angiotensin-converting enzyme inhibitor and exercise training on exercise capacity and skeletal muscle. J Hypertens. 2007;25:1241-8 pubmed
    ..Seven-week-old male SHR were allocated to four groups: sedentary control (C), treatment with perindopril (3 mg/kg per day) (Per), exercise training on a treadmill (EX), and their combination (Per + EX)...
  7. Ghiadoni L, Magagna A, Kardasz I, Taddei S, Salvetti A. Fixed dose combination of perindopril and indapamide improves peripheral vascular function in essential hypertensive patients. Am J Hypertens. 2009;22:506-12 pubmed publisher
    ..on endothelium-dependent and independent vasodilation of 24-week treatment with a fixed-dose combination of perindopril/indapamide (2/0...
  8. Ninomiya T, Donnan G, Anderson N, Bladin C, Chambers B, Gordon G, et al. Effects of the end point adjudication process on the results of the Perindopril Protection Against Recurrent Stroke Study (PROGRESS). Stroke. 2009;40:2111-5 pubmed publisher
    ..The Perindopril Protection Against Recurrent Stroke Study (PROGRESS) was a double-blind randomized trial of blood pressure ..
  9. Mourad J, Le Jeune S, Pirollo A, Mourad C, Gaudouen Y, Lopez Sublet M. Combinations of inhibitors of the renin-angiotensin system with calcium channel blockers for the treatment of hypertension: focus on perindopril/amlodipine. Curr Med Res Opin. 2010;26:2263-76 pubmed publisher
    ..supporting, the use of newer fixed-dose combinations of RAS inhibitors and CCBs, with particular emphasis on perindopril/amlodipine...

More Information

Publications61

  1. Brugts J, Ferrari R, Simoons M. Angiotensin-converting enzyme inhibition by perindopril in the treatment of cardiovascular disease. Expert Rev Cardiovasc Ther. 2009;7:345-60 pubmed publisher
    The angiotensin-converting enzyme (ACE) inhibitor perindopril (Coversyl) is a long-acting lipophilic drug with a high-tissue affinity for the ACE...
  2. Chen X, Bian Z, Lu S, Xu J, Gu C, Yang D, et al. Cardiac protective effect of Astragalus on viral myocarditis mice: comparison with Perindopril. Am J Chin Med. 2006;34:493-502 pubmed
    ..Comparison the myocarditis mice treated with Perindopril (0...
  3. Yin Y, Dalal D, Liu Z, Wu J, Liu D, Lan X, et al. Prospective randomized study comparing amiodarone vs. amiodarone plus losartan vs. amiodarone plus perindopril for the prevention of atrial fibrillation recurrence in patients with lone paroxysmal atrial fibrillation. Eur Heart J. 2006;27:1841-6 pubmed
    The purpose of this trial was to compare the long-term efficacy of low-dose amiodarone with losartan and perindopril (both combined with low-dose amiodarone) for the prevention of atrial fibrillation (AF) recurrence in patients with lone ..
  4. Dufouil C, Chalmers J, Coskun O, Besançon V, Bousser M, Guillon P, et al. Effects of blood pressure lowering on cerebral white matter hyperintensities in patients with stroke: the PROGRESS (Perindopril Protection Against Recurrent Stroke Study) Magnetic Resonance Imaging Substudy. Circulation. 2005;112:1644-50 pubmed
    ..We report here the results of an MRI substudy of PROGRESS (Perindopril Protection Against Recurrent Stroke Study), a randomized trial of blood pressure lowering in subjects with ..
  5. Snyman J, Wessels F. Perindopril: do randomised, controlled trials support an ACE inhibitor class effect? A meta-analysis of clinical trials. Cardiovasc J Afr. 2009;20:127-34 pubmed
    ..This meta-analysis was performed using odds ratios as the parameter of efficacy in a fixed-effects model. Perindopril resulted in significantly fewer patients reaching the primary endpoint versus all other ACEIs combined...
  6. Arima H, Tzourio C, Anderson C, Woodward M, Bousser M, MacMahon S, et al. Effects of perindopril-based lowering of blood pressure on intracerebral hemorrhage related to amyloid angiopathy: the PROGRESS trial. Stroke. 2010;41:394-6 pubmed publisher
    ..in patients with cerebrovascular disease; 6105 patients were randomly assigned to either active treatment (perindopril for all participants plus indapamide for those with neither an indication for nor a contraindication to a ..
  7. Heerspink H, Ninomiya T, Perkovic V, Woodward M, Zoungas S, Cass A, et al. Effects of a fixed combination of perindopril and indapamide in patients with type 2 diabetes and chronic kidney disease. Eur Heart J. 2010;31:2888-96 pubmed publisher
    ..In these analyses of the ADVANCE trial, we assessed the effects of a fixed combination of perindopril-indapamide on renal and cardiovascular outcomes in patients with type 2 diabetes according to baseline CKD ..
  8. Williams B, Lacy P, Thom S, Cruickshank K, Stanton A, Collier D, et al. Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study. Circulation. 2006;113:1213-25 pubmed
    ..ASCOT), examined the impact of 2 different BP lowering-regimens (atenolol+/-thiazide-based versus amlodipine+/-perindopril-based therapy) on derived central aortic pressures and hemodynamics...
  9. Yamada K, Horita T, Takayama M, Takahashi S, Takaba K, Nagata Y, et al. Effect of a centrally active angiotensin converting enzyme inhibitor, perindopril, on cognitive performance in chronic cerebral hypo-perfusion rats. Brain Res. 2011;1421:110-20 pubmed publisher
    We have previously demonstrated that perindopril, an angiotensin-converting enzyme (ACE) inhibitor, ameliorated the cognitive deficits in Alzheimer's disease model animals, independently of its anti-hypertensive effect...
  10. Lizakowski S, Tylicki L, Renke M, Rutkowski P, Heleniak Z, Sławińska Morawska M, et al. Aliskiren and perindopril reduce the levels of transforming growth factor-? in patients with non-diabetic kidney disease. Am J Hypertens. 2012;25:636-9 pubmed publisher
  11. Li Y, Ma S, Du M, Chu W, Cheng X. [Perindopril, amlodipine and telmisartan improve arterial stiffness in patients with hypertension]. Zhonghua Xin Xue Guan Bing Za Zhi. 2009;37:908-12 pubmed
    To investigate the effect of perindopril, amlodipine and telmisartan on improving the artery stiffness in patients with hypertension...
  12. Ruilope L, Schaefer A. Efficacy of Sevikar® compared to the combination of perindopril plus amlodipine on central arterial blood pressure in patients with moderate-to-severe hypertension: Rationale and design of the SEVITENSION study. Contemp Clin Trials. 2011;32:710-6 pubmed publisher
    ..sub-study of the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) investigated the effects of amlodipine/perindopril and atenolol/bendroflumethiazide on central aortic blood pressure (CABP)...
  13. Remko M. Molecular structure and stability of perindopril erbumine and perindopril L-arginine complexes. Eur J Med Chem. 2009;44:101-8 pubmed publisher
    ..used to elucidate molecular properties of the antihypertensive, cardiovascular protective and antithrombotic perindopril ((2S,3aS,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxopentan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-..
  14. Yokusoglu M, Sag C, Cincik M, Uzun M, Kayir H, Koz C, et al. Perindopril, atenolol, and amlodipine prevent aortic ultrastructural changes in rats exposed to ethanol. Med Sci Monit. 2008;14:BR96-102 pubmed
    The effects of perindopril, an angiotensin-converting enzyme inhibitor, atenolol, a beta adrenergic receptor blocker, and amlodipine, a calcium channel blocker, were investigated in chronic alcohol administered rats...
  15. Cockcroft J. ACE inhibition in hypertension: focus on perindopril. Am J Cardiovasc Drugs. 2007;7:303-17 pubmed
    ..In the ASCOT-BPLA trial, antihypertensive therapy based on amlodipine+perindopril significantly reduced total and cardiovascular mortality as well as other clinically relevant outcomes in ..
  16. Watanabe S, Tagawa T, Yamakawa K, Shimabukuro M, Ueda S. Inhibition of the renin-angiotensin system prevents free fatty acid-induced acute endothelial dysfunction in humans. Arterioscler Thromb Vasc Biol. 2005;25:2376-80 pubmed
    ..systemic infusion of lipid/heparin in 10 healthy subjects given a single dose of placebo, losartan (50 mg), or perindopril (8 mg)...
  17. Rodriguez Granillo G, Vos J, Bruining N, Garcia Garcia H, de Winter S, Ligthart J, et al. Long-term effect of perindopril on coronary atherosclerosis progression (from the perindopril's prospective effect on coronary atherosclerosis by angiography and intravascular ultrasound evaluation [PERSPECTIVE] study). Am J Cardiol. 2007;100:159-63 pubmed
    The multicenter EUROPA trial of 12,218 patients showed that perindopril decreased adverse clinical events in patients with established coronary heart disease...
  18. Xiong F, Zhao J, Zeng G, Huang B, Yuan D, Yang Y. Inhibition of AAA in a rat model by treatment with ACEI perindopril. J Surg Res. 2014;189:166-73 pubmed publisher
    The purpose of the present study was to evaluate the effect of a new angiotensin converting enzyme inhibitor perindopril on the formation of experimental abdominal aortic aneurysms (AAAs) in a rat model induced by intraluminal elastase ..
  19. Sag C, Yokusoglu M, Cincik M, Ozkan M, Kayir H, Uzun M, et al. The prevention of myocardial ultrastructural changes by perindopril, atenolol and amlodipine in chronic alcohol administered rats. Pharmacol Res. 2006;53:142-8 pubmed
    The effects of perindopril, an angiotensin converting enzyme inhibitor, atenolol, a beta adrenergic receptor blocker and amlodipine, a calcium channel blocker were investigated in chronic alcohol administered rats...
  20. Ceconi C, Fox K, Remme W, Simoons M, Bertrand M, Parrinello G, et al. ACE inhibition with perindopril and endothelial function. Results of a substudy of the EUROPA study: PERTINENT. Cardiovasc Res. 2007;73:237-46 pubmed
    EUropean trial on Reduction Of cardiac events with Perindopril in stable coronary Artery disease [EUROPA] demonstrates reduction in cardiovascular mortality and myocardial infarction for a possible vascular and antiatherosclerotic effect ..
  21. Campbell D. A review of Perindopril in the reduction of cardiovascular events. Vasc Health Risk Manag. 2006;2:117-24 pubmed
    ..To review studies of the effects of the ACEI perindopril on cardiovascular events...
  22. Chalmers J, Joshi R, Kengne A, MacMahon S. Blood pressure lowering with fixed combination perindopril-indapamide: key findings from ADVANCE. J Hypertens Suppl. 2008;26:S11-5 pubmed
    ADVANCE was planned to investigate the effects of routine blood pressure lowering with the fixed combination perindopril-indapamide on major vascular events in people with type 2 diabetes, irrespective of initial blood pressures or the ..
  23. Mourad J, Lameira D, Guillausseau P. Blood pressure normalization by fixed perindopril/indapamide combination in hypertensive patients with or without associate metabolic syndrome: results of the OPTIMAX 2 study. Vasc Health Risk Manag. 2008;4:443-51 pubmed
    ..by the NCEP-ATP III criteria impacts blood pressure (BP) control in hypertensive patients receiving a fixed perindopril/indapamide combination therapy...
  24. Redekop W, Orlewska E, Maciejewski P, Rutten F, Niessen L. Costs and effects of secondary prevention with perindopril in stable coronary heart disease in Poland: an analysis of the EUROPA study including 1251 Polish patients. Pharmacoeconomics. 2008;26:861-77 pubmed
    To estimate the long-term impact of treatment with perindopril on costs and health effects in patients with stable coronary artery disease in Poland...
  25. Rodriguez Granillo G, de Winter S, Bruining N, Ligthart J, Garcia Garcia H, Valgimigli M, et al. Effect of perindopril on coronary remodelling: insights from a multicentre, randomized study. Eur Heart J. 2007;28:2326-31 pubmed
    This study sought to evaluate the effect of perindopril in coronary remodelling...
  26. Hussein Al Ali S, Al Qubaisi M, Hussein M, Ismail M, Zainal Z, Hakim M. Comparative study of Mg/Al- and Zn/Al-layered double hydroxide-perindopril erbumine nanocomposites for inhibition of angiotensin-converting enzyme. Int J Nanomedicine. 2012;7:4251-62 pubmed publisher
    The intercalation of a drug active, perindopril, into Mg/Al-layered double hydroxide for the formation of a new nanocomposite, PMAE, was accomplished using a simple ion exchange technique...
  27. Ferrari R. Effects of angiotensin-converting enzyme inhibition with perindopril on left ventricular remodeling and clinical outcome: results of the randomized Perindopril and Remodeling in Elderly with Acute Myocardial Infarction (PREAMI) Study. Arch Intern Med. 2006;166:659-66 pubmed
    ..b>Perindopril and Remodeling in Elderly With Acute Myocardial Infarction (PREAMI), a double-blind, randomized, parallel-group,..
  28. Arima H, Anderson C, Omae T, Liu L, Tzourio C, Woodward M, et al. Perindopril-based blood pressure lowering reduces major vascular events in Asian and Western participants with cerebrovascular disease: the PROGRESS trial. J Hypertens. 2010;28:395-400 pubmed publisher
    ..This is a subsidiary analysis of Perindopril Protection Against Recurrent Stroke Study (PROGRESS), a randomized, placebo-controlled trial that established ..
  29. Gao L, Yu D. Molecular mechanism of limbs' postischemic revascularization improved by perindopril in diabetic rats. Chin Med J (Engl). 2008;121:2129-33 pubmed
    ..Diabetic rats were randomly allocated to one of the following treatments for 4 weeks: ACEI by perindopril; perindopril in combination with a nitric oxide synthase (NOS) inhibitor; perindopril in combination with ..
  30. Anan F, Takahashi N, Ooie T, Yufu K, Hara M, Nakagawa M, et al. Effects of valsartan and perindopril combination therapy on left ventricular hypertrophy and aortic arterial stiffness in patients with essential hypertension. Eur J Clin Pharmacol. 2005;61:353-9 pubmed
    ..of an angiotensin II receptor blocker (ARB; valsartan) and an angiotensin converting enzyme inhibitor (ACEI; perindopril) on blood pressure (BP), metabolic profiles, plasma brain natriuretic peptide (BNP) levels, echocardiographic ..
  31. Briggs A, Mihaylova B, Sculpher M, Hall A, Wolstenholme J, Simoons M, et al. Cost effectiveness of perindopril in reducing cardiovascular events in patients with stable coronary artery disease using data from the EUROPA study. Heart. 2007;93:1081-6 pubmed
    The EUropean trial on Reduction Of cardiac events with Perindopril in stable coronary Artery disease (EUROPA) trial has recently reported. To assess the cost effectiveness of perindopril in stable coronary heart disease in the UK...
  32. Patel A, MacMahon S, Chalmers J, Neal B, Woodward M, Billot L, et al. Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial. Lancet. 2007;370:829-40 pubmed
    ..run-in period, 11 140 patients with type 2 diabetes were randomised to treatment with a fixed combination of perindopril and indapamide or matching placebo, in addition to current therapy...
  33. Rahman N, Anwar N, Kashif M. Optimized and validated initial-rate method for the determination of perindopril erbumine in tablets. Chem Pharm Bull (Tokyo). 2006;54:33-6 pubmed
    A simple and sensitive kinetic spectrophotometric method for the determination of perindopril in pharmaceutical preparations is described...
  34. Guo Q, Minami N, Mori N, Nagasaka M, Ito O, Kurosawa H, et al. Effects of estradiol, angiotensin-converting enzyme inhibitor and exercise training on exercise capacity and skeletal muscle in old female rats. Clin Exp Hypertens. 2010;32:76-83 pubmed publisher
    ..025 mg/kg/dose, i.p. twice a week) (Est), perindopril (2 mg/kg/day) (Per), exercise training on a treadmill (15 m/min, 10 grade incline, 60 min/day, 5 days/week) (..
  35. Brugts J, Boersma E, Chonchol M, Deckers J, Bertrand M, Remme W, et al. The cardioprotective effects of the angiotensin-converting enzyme inhibitor perindopril in patients with stable coronary artery disease are not modified by mild to moderate renal insufficiency: insights from the EUROPA trial. J Am Coll Cardiol. 2007;50:2148-55 pubmed
    ..to examine whether the cardioprotective effects of angiotensin-converting enzyme (ACE) inhibitor therapy by perindopril are modified by renal function in patients with stable coronary artery disease...
  36. Barrios V, Escobar C, Divison J, Medialdea F. Low-dose fixed combination of perindopril plus indapamide in the diabetic hypertensive population. Expert Rev Cardiovasc Ther. 2008;6:1063-9 pubmed publisher
    ..GPs) and specialists regarding their clinical experience with the use of the low-dose fixed combination of perindopril 2 mg plus indapamide 0...
  37. Remme W, Deckers J, Fox K, Ferrari R, Bertrand M, Simoons M. Secondary prevention of coronary disease with ACE inhibition--does blood pressure reduction with perindopril explain the benefits in EUROPA?. Cardiovasc Drugs Ther. 2009;23:161-70 pubmed publisher
    We determined whether blood pressure (BP) lowering by perindopril was related to its benefit in the EUROPA study...
  38. Sung S, Wu T, Lin S, Chen J. Efficacy of a very-low-dose combination of perindopril and indapamide--preterax compared with cilazapril monotherapy in patients with inadequate blood pressure control--a randomized, double-blind, add-on study. J Chin Med Assoc. 2008;71:247-53 pubmed publisher
    ..They were then randomized to receive either preterax (perindopril 2 mg and indapamide 0.625 mg) or cilazapril 2...
  39. Brugts J, Isaacs A, Boersma E, van Duijn C, Uitterlinden A, Remme W, et al. Genetic determinants of treatment benefit of the angiotensin-converting enzyme-inhibitor perindopril in patients with stable coronary artery disease. Eur Heart J. 2010;31:1854-64 pubmed publisher
    ..I receptor and bradykinin type I receptor genes, were significantly associated with the treatment benefit of perindopril after multivariate adjustment for confounders and correction for multiple testing...
  40. Hussein Al Ali S, Al Qubaisi M, Hussein M, Ismail M, Zainal Z, Hakim M. Controlled release and angiotensin-converting enzyme inhibition properties of an antihypertensive drug based on a perindopril erbumine-layered double hydroxide nanocomposite. Int J Nanomedicine. 2012;7:2129-41 pubmed publisher
    The intercalation of perindopril erbumine into Zn/Al-NO(3)-layered double hydroxide resulted in the formation of a host-guest type of material...
  41. Asmar R, Garcia Puig J, Gosse P, Karpov Y, De Leeuws P, Magometschniggs D, et al. Ambulatory blood pressure in hypertensive patients with left ventricular hypertrophy: efficacy of first-line combination perindopril/indapamide therapy. Vasc Health Risk Manag. 2007;3:371-80 pubmed
    ..In this prospectively designed ancillary study of the PICXEL trial, the effects of first-line combination perindopril/indapamide on ambulatory BP were compared with those of monotherapy with enalapril in 127 patients...
  42. Basturk T, Altuntas Y, Kurklu A, Aydin L, Eren N, Unsal A. Urinary N-acetyl B glucosaminidase as an earlier marker of diabetic nephropathy and influence of low-dose perindopril/indapamide combination. Ren Fail. 2006;28:125-8 pubmed
    ..diabetic patients and determining changes in urinary NAG excretion after treatment with low-dose combination perindopril (2 mg)/ indapamide (0.625 mg)/o.d...
  43. Comini L, Bachetti T, Cargnoni A, Bastianon D, Gitti G, Ceconi C, et al. Therapeutic modulation of the nitric oxide: all ace inhibitors are not equivalent. Pharmacol Res. 2007;56:42-8 pubmed
    ..In this experimental study, Sprague-Dawley rats were treated with five different ACE inhibitors (enalapril, perindopril, quinapril, ramipril, and trandolapril) at equihypotensive doses...
  44. Zheng Z, Chen H, Ke G, Fan Y, Zou H, Sun X, et al. Protective effect of perindopril on diabetic retinopathy is associated with decreased vascular endothelial growth factor-to-pigment epithelium-derived factor ratio: involvement of a mitochondria-reactive oxygen species pathway. Diabetes. 2009;58:954-64 pubmed publisher
    ..Diabetic rats and control animals were randomly assigned to receive perindopril or vehicle for 24 weeks, and bovine retinal capillary endothelial cells (BRECs) were incubated with normal or ..
  45. Williams A, Kenny D, Wilson D, Fagenello G, Nelson M, Dunstan F, et al. Effects of atenolol, perindopril and verapamil on haemodynamic and vascular function in Marfan syndrome - a randomised, double-blind, crossover trial. Eur J Clin Invest. 2012;42:891-9 pubmed publisher
    ..We therefore performed a prospective, randomised, double-blind, crossover trial to compare the effects of these three agents on large artery function and central aortic pressure in patients with Marfan syndrome...
  46. Perkovic V, Ninomiya T, Arima H, Gallagher M, Jardine M, Cass A, et al. Chronic kidney disease, cardiovascular events, and the effects of perindopril-based blood pressure lowering: data from the PROGRESS study. J Am Soc Nephrol. 2007;18:2766-72 pubmed
    ..The Perindopril Protection against Recurrent Stroke Study (PROGRESS) study enrolled 6105 participants with cerebrovascular ..
  47. Mourad J, Nguyen V, Lopez Sublet M, Waeber B. Blood pressure normalization in a large population of hypertensive patients treated with perindopril/indapamide combination: results of the OPTIMAX trial. Vasc Health Risk Manag. 2007;3:173-80 pubmed
    To determine if the fixed-dose perindopril/indapamide combination (Per/Ind) normalizes blood pressure (BP) in the same fraction of hypertensive patients when treated in everyday practice or in controlled trials...
  48. You D, Cochain C, Loinard C, Vilar J, Mees B, Duriez M, et al. Combination of the angiotensin-converting enzyme inhibitor perindopril and the diuretic indapamide activate postnatal vasculogenesis in spontaneously hypertensive rats. J Pharmacol Exp Ther. 2008;325:766-73 pubmed publisher
    ..hypertension abrogates postnatal vasculogenesis, and 2) antihypertensive treatment based on the combination of perindopril (angiotensin-converting enzyme inhibitor) and indapamide (diuretic) may counteract hypertension-induced ..
  49. Tousoulis D, Kourtellaris P, Antoniades C, Vasiliadou C, Papageorgiou N, Tentolouris C, et al. Effects of irbesartan and perindopril on forearm reactive hyperemia and inflammatory process, in normotensive patients with coronary artery disease. Int J Cardiol. 2008;124:127-9 pubmed
  50. Celik T, Iyisoy A, Acikel C, Yuksel C, Celik M, Yaman H, et al. The comparative effects of metoprolol and perindopril on aortic elasticity in young patients with prehypertension. Blood Press Monit. 2008;13:169-76 pubmed publisher
    ..Accordingly, the purpose of the current study was to analyze the comparative effects of metoprolol and perindopril on aortic elasticity in young patients with prehypertension after 6 months of therapy.
  51. Waeber B, de la Sierra A, Ruilope L. The ADVANCE trial: clarifying the role of perindopril/indapamide fixed-dose combination in the reduction of cardiovascular and renal events in patients with diabetes mellitus. Am J Cardiovasc Drugs. 2009;9:283-91 pubmed publisher
    ..The systematic use of a fixed-dose combination containing the ACE inhibitor perindopril and the diuretic indapamide afforded substantial protection against cardiovascular mortality and myocardial ..
  52. Duboc D, Meune C, Pierre B, Wahbi K, Eymard B, Toutain A, et al. Perindopril preventive treatment on mortality in Duchenne muscular dystrophy: 10 years' follow-up. Am Heart J. 2007;154:596-602 pubmed
    ..on left ventricular (LV) function, our aim was to examine the long-term impact of a preventive treatment with perindopril on mortality in children with DMD. Patients with DMD between the ages of 9...