isatin

Summary

Summary: An indole-dione that is obtained by oxidation of indigo blue. It is a MONOAMINE OXIDASE INHIBITOR and high levels have been found in urine of PARKINSONISM patients.

Top Publications

  1. Verma M, Pandeya S, Singh K, Stables J. Anticonvulsant activity of Schiff bases of isatin derivatives. Acta Pharm. 2004;54:49-56 pubmed
    Schiff bases of N-methyl and N-acetyl isatin derivatives with different aryl amines have been synthesized and screened for anticonvulsant activities against maximal electroshock (MES) and subcutaneous metrazole (ScMet)...
  2. Chohan Z, Pervez H, Rauf A, Khan K, Supuran C. Isatin-derived antibacterial and antifungal compounds and their transition metal complexes. J Enzyme Inhib Med Chem. 2004;19:417-23 pubmed
    ..All the synthesized compounds have shown good affinity as antibacterial and/or antifungal agents which increased in most of the cases on complexation with the metal ions. ..
  3. Pandeya S, Smitha S, Jyoti M, Sridhar S. Biological activities of isatin and its derivatives. Acta Pharm. 2005;55:27-46 pubmed
    b>Isatin is an endogenous compound identified in humans that possesses a wide range of biological activities...
  4. Mawatari K, Segawa M, Masatsuka R, Hanawa Y, Iinuma F, Watanabe M. Fluorimetric determination of isatin in human urine and serum by liquid chromatography postcolumn photoirradiation. Analyst. 2001;126:33-6 pubmed
    For the fluorimetric determination of isatin in human urine and serum, HPLC-postcolumn photoirradiation using a mobile phase has been developed. Isatin in the urine or serum sample was separated on a Capcell Pak C1 column (250 x 4...
  5. Song J, Hou L, Ju C, Zhang J, Ge Y, Yue W. Isatin inhibits proliferation and induces apoptosis of SH-SY5Y neuroblastoma cells in vitro and in vivo. Eur J Pharmacol. 2013;702:235-41 pubmed publisher
    The purpose of this study was to investigate the anti-tumor effects of the isatin in vitro and in vivo. Human neuroblastoma cells (SH-SY5Y) were exposed to isatin at various concentrations (0, 50, 100, 200 ?mol/l) for 48 h...
  6. Vine K, Locke J, Ranson M, Benkendorff K, Pyne S, Bremner J. In vitro cytotoxicity evaluation of some substituted isatin derivatives. Bioorg Med Chem. 2007;15:931-8 pubmed
    ..These results indicate that di- and tri-substituted isatins may be useful leads for anticancer drug development in the future. ..
  7. Filomeni G, Cerchiaro G, da Costa Ferreira A, De Martino A, Pedersen J, Rotilio G, et al. Pro-apoptotic activity of novel Isatin-Schiff base copper(II) complexes depends on oxidative stress induction and organelle-selective damage. J Biol Chem. 2007;282:12010-21 pubmed
    We characterized the pro-apoptotic activity of two new synthesized isatin-Schiff base copper(II) complexes, obtained from isatin and 1,3-diaminopropane or 2-(2-aminoethyl)pyridine: (Cu(isapn)) and (Cu(isaepy)(2)), respectively...
  8. Chen L, Wang Y, Lin Y, Chou S, Chen S, Liu L, et al. Synthesis and evaluation of isatin derivatives as effective SARS coronavirus 3CL protease inhibitors. Bioorg Med Chem Lett. 2005;15:3058-62 pubmed
    N-Substituted isatin derivatives were prepared from the reaction of isatin and various bromides via two steps...
  9. Gonzalez A, Quirante J, Nieto J, Almeida M, Saraiva M, Planas A, et al. Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors. Bioorg Med Chem Lett. 2009;19:5270-3 pubmed publisher
    The isatin core structure was found to be a novel chemical scaffold in transthyretin (TTR) fibrillogenesis inhibitor design...

More Information

Publications62

  1. Crumeyrolle Arias M, Medvedev A, Cardona A, Barritault D, Glover V. In situ imaging of specific binding of [3H]isatin in rat brain. J Neurochem. 2003;84:618-20 pubmed
    b>Isatin is an endogenous indole that influences a range of processes both in vivo and in vitro. It has a distinct and discontinuous distribution in the brain, as well as in other mammalian tissues and body fluids...
  2. Ogata A, Hamaue N, Terado M, Minami M, Nagashima K, Tashiro K. Isatin, an endogenous MAO inhibitor, improves bradykinesia and dopamine levels in a rat model of Parkinson's disease induced by Japanese encephalitis virus. J Neurol Sci. 2003;206:79-83 pubmed
    b>Isatin, an endogenous monoamine oxidase (MAO) inhibitor, has an important role in the control of neurotransmitter concentration...
  3. Zhou Y, Zhao Z, Xie J. Effects of isatin on rotational behavior and DA levels in caudate putamen in Parkinsonian rats. Brain Res. 2001;917:127-32 pubmed
    b>Isatin was a potent endogenous monoamine oxidase (MAO) inhibitor that is more active against MAO-B than MAO-A...
  4. Medvedev A, Bussygyna O, Pyatakova N, Glover V, Severina I. Effect of isatin on nitric oxide-stimulated soluble guanylate cyclase from human platelets. Biochem Pharmacol. 2002;63:763-6 pubmed
    b>Isatin, an endogenous indole, has previously been shown to inhibit atrial natriuretic peptide (ANP)-stimulated particulate guanylate cyclase activity...
  5. Fedchenko V, Globa A, Kaloshin A, Kapitsa I, Nerobkova L, Val dman E, et al. The effect of short-term administration of (-)-deprenyl and isatin on the expressions of some genes in the mouse brain cortex. Med Sci Monit. 2008;14:BR269-73 pubmed
    b>Isatin (indoledione 2,3) is an endogenous indole found in the mammalian brain, peripheral tissues, and body fluids. It exhibits many neurophysiological and neuropharmacological effects...
  6. Igosheva N, Lorz C, O Conner E, Glover V, Mehmet H. Isatin, an endogenous monoamine oxidase inhibitor, triggers a dose- and time-dependent switch from apoptosis to necrosis in human neuroblastoma cells. Neurochem Int. 2005;47:216-24 pubmed
    b>Isatin is an endogenous indole that is increased in stress, inhibits monoamine oxidase (MAO) B and improves bradykinesia and striatal dopamine levels in rat models of Parkinson's disease...
  7. Sriram D, Bal T, Yogeeswari P. Newer aminopyrimidinimino isatin analogues as non-nucleoside HIV-1 reverse transcriptase inhibitors for HIV and other opportunistic infections of AIDS: design, synthesis and biological evaluation. Farmaco. 2005;60:377-84 pubmed
    ..In this paper, we designed aminopyrimidinimino isatin lead compound as a novel non-nucleoside reverse transcriptase inhibitor (NNRTI) with broad-spectrum ..
  8. Buneeva O, Gnedenko O, Panova N, Medvedeva M, Ivanov I, Medvedev A. [Glycerol-3-phosphate dehydrogenase--cytosolic isatin-binding protein]. Biomed Khim. 2003;49:627-31 pubmed
    b>Isatin is an endogenous indole widely distributed in mammalian tissues and body fluids. The presence of isatin-binding proteins has been recognised in particulate and soluble fractions of various organs and tissues...
  9. Chiyanzu I, Clarkson C, Smith P, Lehman J, Gut J, Rosenthal P, et al. Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives. Bioorg Med Chem. 2005;13:3249-61 pubmed
    A new class of 4-aminoquinoline derivatives based on the natural product isatin scaffold were designed and synthesized for biological evaluation against three strains of the malaria parasite Plasmodium falciparum...
  10. Podichetty A, Wagner S, Schröer S, Faust A, Schäfers M, Schober O, et al. Fluorinated isatin derivatives. Part 2. New N-substituted 5-pyrrolidinylsulfonyl isatins as potential tools for molecular imaging of caspases in apoptosis. J Med Chem. 2009;52:3484-95 pubmed publisher
    ..analogues of the small molecule nonpeptide caspase inhibitor (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin (1), which may be useful for the development of caspase-targeted radioligands, were synthesized and their ..
  11. Pandeya S, Sriram D, Yogeeswari P, Ananthan S. Antituberculous activity of norfloxacin mannich bases with isatin derivatives. Chemotherapy. 2001;47:266-9 pubmed
    Mannich bases of norfloxacin were synthesized by reacting them with formaldehyde and several isatin derivatives. The compounds were evaluated in vitro against Mycobacterium tuberculosis H37R(v) at 12...
  12. Buneeva O, Gnedenko O, Zgoda V, Kopylov A, Glover V, Ivanov A, et al. Isatin-binding proteins of rat and mouse brain: proteomic identification and optical biosensor validation. Proteomics. 2010;10:23-37 pubmed publisher
    b>Isatin (indole-2,3-dione) is an endogenous indole that has a distinct and discontinuous distribution in the brain and in other mammalian tissues and body fluids. Its output is increased under conditions of stress and anxiety...
  13. Aboul Fadl T, Bin Jubair F, Aboul Wafa O. Schiff bases of indoline-2,3-dione (isatin) derivatives and nalidixic acid carbohydrazide, synthesis, antitubercular activity and pharmacophoric model building. Eur J Med Chem. 2010;45:4578-86 pubmed publisher
    ..Accordingly, the current work involved design and synthesis of Schiff bases of nalidixic acid carbohydrazide and isatin derivatives (5,6a-f and 7,8a-c)...
  14. Pandeya S, Sriram D, Nath G, De Clercq E. Synthesis, antibacterial, antifungal and anti-HIV evaluation of Schiff and Mannich bases of isatin and its derivatives with triazole. Arzneimittelforschung. 2000;50:55-9 pubmed
    b>Isatin (indole 2,3-dione) and its 5-chloro and 5-bromo derivatives have been reacted with 3-(4'-pyridyl)-4-amino-5-mercapto-4-(H)-1,2,4-triazole to form Schiff bases and the N-Mannich bases of these compounds were synthesised by reacting ..
  15. Zhou L, Liu Y, Zhang W, Wei P, Huang C, Pei J, et al. Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors. J Med Chem. 2006;49:3440-3 pubmed
    A series of isatin derivatives were synthesized and tested against SARS CoV 3C-like protease...
  16. Zhou D, Chu W, Rothfuss J, Zeng C, Xu J, Jones L, et al. Synthesis, radiolabeling, and in vivo evaluation of an 18F-labeled isatin analog for imaging caspase-3 activation in apoptosis. Bioorg Med Chem Lett. 2006;16:5041-6 pubmed
    A non-peptide-based isatin sulfonamide analog, WC-II-89, was synthesized and its inhibition toward recombinant human caspase-3 and other caspases was determined...
  17. Pandeya S, Sriram D, Nath G, Declercq E. Synthesis, antibacterial, antifungal and anti-HIV activities of Schiff and Mannich bases derived from isatin derivatives and N-[4-(4'-chlorophenyl)thiazol-2-yl] thiosemicarbazide. Eur J Pharm Sci. 1999;9:25-31 pubmed
    b>Isatin, its 5-chloro and 5-bromo derivatives have been reacted with N-[4-(4'-chlorophenyl)thiazol-2-yl] thiosemicarbazide to form Schiff bases and the N-Mannich bases of these compounds were synthesized by reacting them with formaldehyde ..
  18. Bal T, Anand B, Yogeeswari P, Sriram D. Synthesis and evaluation of anti-HIV activity of isatin beta-thiosemicarbazone derivatives. Bioorg Med Chem Lett. 2005;15:4451-5 pubmed
    On the basis of pharmacophoric modelling studies of existing NNRTIs, a series of isatin beta-thiosemicarbazone derivatives was synthesized and evaluated for their anti-HIV activity in HTLV-III(B) strain in the CEM cell line...
  19. Cao J, Gao H, Bemis G, Salituro F, Ledeboer M, Harrington E, et al. Structure-based design and parallel synthesis of N-benzyl isatin oximes as JNK3 MAP kinase inhibitors. Bioorg Med Chem Lett. 2009;19:2891-5 pubmed publisher
    A series of N-benzylated isatin oximes were developed as inhibitors of the mitogen-activated kinase, JNK3...
  20. Sridhar S, Saravanan M, Ramesh A. Synthesis and antibacterial screening of hydrazones, Schiff and Mannich bases of isatin derivatives. Eur J Med Chem. 2001;36:615-25 pubmed
    Schiff bases and hydrazones of substituted isatins (1-28) were prepared by reacting isatin and aromatic primary amines/hydrazines...
  21. Sridhar S, Pandeya S, Stables J, Ramesh A. Anticonvulsant activity of hydrazones, Schiff and Mannich bases of isatin derivatives. Eur J Pharm Sci. 2002;16:129-32 pubmed
    In the present study, anticonvulsant activity of hydrazones, Schiff and Mannich bases of isatin were evaluated by maximal electroshock method (MES) and metrazol-induced convulsions (MET) at 30, 100 and 300 mg/kg dose levels...
  22. Krishnegowda G, Prakasha Gowda A, Tagaram H, Carroll K, Irby R, Sharma A, et al. Synthesis and biological evaluation of a novel class of isatin analogs as dual inhibitors of tubulin polymerization and Akt pathway. Bioorg Med Chem. 2011;19:6006-14 pubmed publisher
    ..More importantly, the strategy of microtubule and Akt dual inhibitors might be a promising direction for developing novel drugs for cancer. ..
  23. Diaz P, Phatak S, Xu J, Astruc Diaz F, Cavasotto C, Naguib M. 6-Methoxy-N-alkyl isatin acylhydrazone derivatives as a novel series of potent selective cannabinoid receptor 2 inverse agonists: design, synthesis, and binding mode prediction. J Med Chem. 2009;52:433-44 pubmed publisher
    Recently, we discovered and reported a series of N-alkyl isatin acylhydrazone derivatives that are potent CB2 agonists...
  24. Havrylyuk D, Kovach N, Zimenkovsky B, Vasylenko O, Lesyk R. Synthesis and anticancer activity of isatin-based pyrazolines and thiazolidines conjugates. Arch Pharm (Weinheim). 2011;344:514-22 pubmed publisher
    The synthesis and antitumor activity screening of novel isatin based conjugates with thiazolidine and pyrazoline moieties were performed...
  25. Solomon V, Hu C, Lee H. Hybrid pharmacophore design and synthesis of isatin-benzothiazole analogs for their anti-breast cancer activity. Bioorg Med Chem. 2009;17:7585-92 pubmed publisher
    A hybrid pharmacophore approach was used to design and synthesize isatin-benzothiazole analogs to examine their anti-breast cancer activity...
  26. Chu W, Rothfuss J, Zhou D, Mach R. Synthesis and evaluation of isatin analogs as caspase-3 inhibitors: introduction of a hydrophilic group increases potency in a whole cell assay. Bioorg Med Chem Lett. 2011;21:2192-7 pubmed publisher
    A series of isatin analogs containing a hydrophilic group, including a pyridine ring, ethylene glycol group, and a triazole ring, have been synthesized, and their inhibition potency for caspase-3 was measured both in vitro (i.e...
  27. Buneeva O, Gnedenko O, Medvedeva M, Ivanov I, Glover V, Medvedev A. [Interaction of pyruvate kinase with isatin and deprenyl]. Biomed Khim. 2006;52:413-8 pubmed
    The glycolytic enzyme, pyruvate kinase, exhibits moderate affinity [3H]isatin binding (KD approximately 10 microM), which is inhibited by ATP (IC50 25 microM) and deprenyl (IC50 5 microM)...
  28. Chapman J, Magee W, Stukenbrok H, Beckius G, Milici A, Tracey W. A novel nonpeptidic caspase-3/7 inhibitor, (S)-(+)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin reduces myocardial ischemic injury. Eur J Pharmacol. 2002;456:59-68 pubmed
    ..of a novel, nonpeptidic, caspase 3/7-selective inhibitor, (S)-(+)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin (MMPSI) for reducing ischemic injury in isolated rabbit hearts or cardiomyocytes was evaluated. MMPSI (0...
  29. Zou P, Koh H. Determination of indican, isatin, indirubin and indigotin in Isatis indigotica by liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom. 2007;21:1239-46 pubmed
    ..ionization tandem mass spectrometry (LC/ESI-MS/MS) method was developed to determine indican, isatin, indirubin and indigotin in the roots and leaves of I. indigotica...
  30. Cresawn S, Prins C, Latner D, Condit R. Mapping and phenotypic analysis of spontaneous isatin-beta-thiosemicarbazone resistant mutants of vaccinia virus. Virology. 2007;363:319-32 pubmed
    Treatment of wild type vaccinia virus infected cells with the anti-poxviral drug isatin-beta-thiosemicarbazone (IBT) induces the viral postreplicative transcription apparatus to synthesize longer-than-normal mRNAs through an unknown ..
  31. Sridhar S, Pandeya S, De Clercq E. Synthesis and anti-HIV activity of some isatin derivatives. Boll Chim Farm. 2001;140:302-5 pubmed
    b>Isatin/5-substituted Isatin was reacted with 2-aminothiazole, 2-aminopyridine, 4-methoxyaniline to form Schiff bases and the N-Mannich bases of the above Schiff bases were synthesized by reacting with formaldehyde and piperidine...
  32. Bekircan O, Bektas H. Synthesis of Schiff and Mannich bases of isatin derivatives with 4-amino-4,5-dihydro-1H-1,2,4-triazole-5-ones. Molecules. 2008;13:2126-35 pubmed
    ..b>Isatin and 5-chloroisatin were added to 3 to form Schiff bases 4 and N-Mannich bases 5 of these compounds were ..
  33. Pirrung M, Pansare S, Sarma K, Keith K, Kern E. Combinatorial optimization of isatin-beta-thiosemicarbazones as anti-poxvirus agents. J Med Chem. 2005;48:3045-50 pubmed
    ..Using a combinatorial method, variants of the basic isatin-beta-thiosemicarbazone structure were prepared and examined for cytotoxicity and antiviral activity in vaccinia ..
  34. Itoh T, Ishikawa H, Hayashi Y. Asymmetric aldol reaction of acetaldehyde and isatin derivatives for the total syntheses of ent-convolutamydine E and CPC-1 and a half fragment of madindoline A and B. Org Lett. 2009;11:3854-7 pubmed publisher
    The asymmetric aldol reaction of isatin derivatives and acetaldehyde has been developed using 4-hydroxydiarylprolinol as a catalyst, affording the aldol products with high enantioselectivity, these products being key intermediates in the ..
  35. Pandeya S, Sriram D, Nath G, De Clercq E. Synthesis and antimicrobial activity of Schiff and Mannich bases of isatin and its derivatives with pyrimidine. Farmaco. 1999;54:624-8 pubmed
    b>Isatin and its derivatives have been reacted with 4-(4'-chlorophenyl)-6-(4"-methyl phenyl)-2-aminopyrimidine to form Schiff bases and the N-Mannich bases of these compounds were synthesized by reacting them with formaldehyde and ..
  36. Pandeya S, Sriram D, Nath G, De Clercq E. Synthesis, antibacterial, antifungal and anti-HIV evaluation of Schiff and Mannich bases of isatin derivatives with 3-amino-2-methylmercapto quinazolin-4(3H)-one. Pharm Acta Helv. 1999;74:11-7 pubmed
    b>Isatin (Indole 2,3-dione), its 5-chloro and 5-bromo derivatives were added to 3-amino-2-methylmercapto quinazolin-4(3H)-one to form Schiff bases and the N-Mannich bases of these compounds were synthesized by reacting with formaldehyde and ..
  37. Pandeya S, Raja A, Stables J. Synthesis of isatin semicarbazones as novel anticonvulsants--role of hydrogen bonding. J Pharm Pharm Sci. 2002;5:266-71 pubmed
    A series of substituted isatin semicarbazones and related bioisosteric hydrazones were designed and synthesised to meet the structural requirements essential for anticonvulsant properties...
  38. Hans R, Gut J, Rosenthal P, Chibale K. Comparison of the antiplasmodial and falcipain-2 inhibitory activity of beta-amino alcohol thiolactone-chalcone and isatin-chalcone hybrids. Bioorg Med Chem Lett. 2010;20:2234-7 pubmed publisher
    ..biological evaluation of two novel series of natural-product-like hybrids based on the chalcone, thiolactone and isatin scaffolds is herein described...
  39. Nguyen Q, Smith G, Glaser M, Perumal M, Arstad E, Aboagye E. Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-3/7 specific [18F]-labeled isatin sulfonamide. Proc Natl Acad Sci U S A. 2009;106:16375-80 pubmed publisher
    ..We recently designed a library of isatin-5 sulfonamides and selected [18F]ICMT-11 for further evaluation on the basis of subnanomolar affinity for ..
  40. Kettle A, Clark B, Winterbourn C. Superoxide converts indigo carmine to isatin sulfonic acid: implications for the hypothesis that neutrophils produce ozone. J Biol Chem. 2004;279:18521-5 pubmed
    ..Evidence for the proposal was based largely on the chemistry of ozone reacting with indigo carmine to produce isatin sulfonic acid...
  41. Hall M, Salam N, Hellawell J, Fales H, Kensler C, Ludwig J, et al. Synthesis, activity, and pharmacophore development for isatin-beta-thiosemicarbazones with selective activity toward multidrug-resistant cells. J Med Chem. 2009;52:3191-204 pubmed publisher
    ..Several isatin-beta-thiosemicarbazones from our initial study have been validated and a range of analogues synthesized and tested...
  42. Cerchiaro G, Aquilano K, Filomeni G, Rotilio G, Ciriolo M, Ferreira A. Isatin-Schiff base copper(II) complexes and their influence on cellular viability. J Inorg Biochem. 2005;99:1433-40 pubmed
    Some copper(II) complexes with isatin (isa) or imine ligands derived from isatin were prepared, characterized by analytical and spectroscopic techniques, and had their biological activity toward proliferation of two different cell types ..
  43. Wang Q, Mach R, Reichert D. Docking and 3D-QSAR studies on isatin sulfonamide analogues as caspase-3 inhibitors. J Chem Inf Model. 2009;49:1963-73 pubmed publisher
    To provide insight of their inhibition mechanism and facilitate the design of more potent ligands, a series of 59 isatin sulfonamide analogues were docked to the X-ray structure of caspase-3, one of the important cysteine aspartyl-..
  44. Hamaue N, Minami M, Terado M, Hirafuji M, Endo T, Machida M, et al. Comparative study of the effects of isatin, an endogenous MAO-inhibitor, and selegiline on bradykinesia and dopamine levels in a rat model of Parkinson's disease induced by the Japanese encephalitis virus. Neurotoxicology. 2004;25:205-13 pubmed
    We previously reported that exogenously administered isatin, an endogenous monoamine oxidase (MAO) inhibitor, significantly increased acetylcholine (ACh) and dopamine (DA) levels in the rat striatum...
  45. Smith G, Glaser M, Perumal M, Nguyen Q, Shan B, Arstad E, et al. Design, synthesis, and biological characterization of a caspase 3/7 selective isatin labeled with 2-[18F]fluoroethylazide. J Med Chem. 2008;51:8057-67 pubmed publisher
    ..To realize this potential, we aimed to develop 18F-labeled isatin sulfonamides with high metabolic stability and moderate lipophilicity while retaining selectivity and affinity for ..
  46. Ramshid P, Jagadeeshan S, Krishnan A, Mathew M, Nair S, Pillai M. Synthesis and in vitro evaluation of some isatin-thiazolidinone hybrid analogues as anti-proliferative agents. Med Chem. 2010;6:306-12 pubmed
    A range of isatin-thiazolidinone hybrid analogues were synthesized and their cytotoxicity was evaluated against several cancer cell lines in vitro...
  47. Kang I, Wang L, Hsu T, Yueh A, Lee C, Lee Y, et al. Isatin-?-thiosemicarbazones as potent herpes simplex virus inhibitors. Bioorg Med Chem Lett. 2011;21:1948-52 pubmed publisher
    A series of isatin-?-thiosemicarbazones have been designed and evaluated for antiviral activity against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in a plaque reduction assay...
  48. Matesic L, Locke J, Bremner J, Pyne S, Skropeta D, Ranson M, et al. N-phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents. Bioorg Med Chem. 2008;16:3118-24 pubmed publisher
    ..The results allowed further development of structure-activity relationships. The compound 5,7-dibromo-N-(1-naphthylmethyl)-1H-indole-2,3-dione 5a was the most potent against U937 cells with an IC(50) value of 0.19 microM. ..
  49. Lee J, Bansal T, Jayaraman A, Bentley W, Wood T. Enterohemorrhagic Escherichia coli biofilms are inhibited by 7-hydroxyindole and stimulated by isatin. Appl Environ Microbiol. 2007;73:4100-9 pubmed
    ..5-Hydroxyindole also decreased biofilm formation 11-fold for EHEC and 6-fold for K-12. In contrast, isatin (indole-2,3-dione) increased biofilm formation fourfold for EHEC, while it had no effect for K-12...
  50. Chen D, Zhou D, Chu W, Herrbrich P, Jones L, Rothfuss J, et al. Comparison of radiolabeled isatin analogs for imaging apoptosis with positron emission tomography. Nucl Med Biol. 2009;36:651-8 pubmed publisher
    ..control groups was lower than that observed in previously published data with [18F]WC-II-89, another radiolabeled isatin analog. Activation was also confirmed in the liver and spleen but not in fat by Western blot...
  51. Crumeyrolle Arias M, Buneeva O, Zgoda V, Kopylov A, Cardona A, Tournaire M, et al. Isatin binding proteins in rat brain: in situ imaging, quantitative characterization of specific [3H]isatin binding, and proteomic profiling. J Neurosci Res. 2009;87:2763-72 pubmed publisher
    b>Isatin (indole-2,3-dione) is an endogenous indole that has a distinct and discontinuous distribution in the brain and in other mammalian tissues and body fluids. Its output is increased under conditions of stress and anxiety...
  52. Edwards V, Benkendorff K, Young F. Marine compounds selectively induce apoptosis in female reproductive cancer cells but not in primary-derived human reproductive granulosa cells. Mar Drugs. 2012;10:64-83 pubmed publisher
    ..These marine compounds therefore have potential for development as treatments for female reproductive cancers...
  53. Sriram D, Bal T, Yogeeswari P. Aminopyrimidinimino isatin analogues: design of novel non- nucleoside HIV-1 reverse transcriptase inhibitors with broad-spectrum chemotherapeutic properties. J Pharm Pharm Sci. 2005;8:565-77 pubmed
    ..In this paper, we describe an aminopyrimidinimino isatin lead compound as a novel non-nucleoside reverse transcriptase inhibitor with broad-spectrum chemotherapeutic ..