yohimbine

Summary

Summary: A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of ERECTILE DYSFUNCTION.

Top Publications

  1. Dhir A, Kulkarni S. Effect of addition of yohimbine (alpha-2-receptor antagonist) to the antidepressant activity of fluoxetine or venlafaxine in the mouse forced swim test. Pharmacology. 2007;80:239-43 pubmed
    ..With this background in mind, the present study was undertaken to monitor the effect of addition of yohimbine (alpha(2)-adrenoceptor antagonist) to the effect of fluoxetine (selective serotonin reuptake inhibitor) or ..
  2. Davis A, Shields A, Brigman J, Norcross M, McElligott Z, Holmes A, et al. Yohimbine impairs extinction of cocaine-conditioned place preference in an alpha2-adrenergic receptor independent process. Learn Mem. 2008;15:667-76 pubmed publisher
    ..We found that pre-extinction systemic treatment with the alpha(2)-AR antagonist yohimbine impaired cocaine CPP extinction in C57BL/6J mice, an effect that was not mimicked by the more selective alpha(2)-..
  3. Banna K, Back S, Do P, See R. Yohimbine stress potentiates conditioned cue-induced reinstatement of heroin-seeking in rats. Behav Brain Res. 2010;208:144-8 pubmed publisher
    ..Using an animal model of relapse, we assessed the effects of the pharmacological stressor, yohimbine (1.25 or 2...
  4. Li H, Wang Y, Wang H, Cao W, Yu X, Lu D, et al. Berberine protects against lipopolysaccharide-induced intestinal injury in mice via alpha 2 adrenoceptor-independent mechanisms. Acta Pharmacol Sin. 2011;32:1364-72 pubmed publisher
    ..Male BALB/c mice were administered intragastrically with distilled water (0.1 mL/10 g), Ber (50 mg/kg) alone, yohimbine (2 mg/kg) alone, or Ber (50 mg/kg) in combination with yohimbine (2 mg/kg) for 3 d...
  5. Richards J, Simms J, Steensland P, Taha S, Borgland S, Bonci A, et al. Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long-Evans rats. Psychopharmacology (Berl). 2008;199:109-17 pubmed publisher
    ..the role of orexin-1/hypocretin-1 receptors in operant self-administration of ethanol and sucrose and in yohimbine-induced reinstatement of ethanol and sucrose seeking...
  6. Caruso M, Roberts A, Bissoon L, Self K, Guillot T, Greenway F. An evaluation of mesotherapy solutions for inducing lipolysis and treating cellulite. J Plast Reconstr Aesthet Surg. 2008;61:1321-4 pubmed
    ..The following mesotherapy solutions were tested: aminophylline; yohimbine; isoproterenol; melilotus; aminophylline with melilotus; aminophylline with isoproterenol; aminophylline with ..
  7. Marinelli P, Funk D, Juzytsch W, Harding S, Rice K, Shaham Y, et al. The CRF1 receptor antagonist antalarmin attenuates yohimbine-induced increases in operant alcohol self-administration and reinstatement of alcohol seeking in rats. Psychopharmacology (Berl). 2007;195:345-55 pubmed
    b>Yohimbine is an alpha-2 adrenoreceptor antagonist that provokes stress- and anxiety-like responses in both humans and laboratory animals. In rats, yohimbine increases operant alcohol self-administration and reinstates alcohol seeking...
  8. Landau A, Doudet D, Jakobsen S. Amphetamine challenge decreases yohimbine binding to ?2 adrenoceptors in Landrace pig brain. Psychopharmacology (Berl). 2012;222:155-63 pubmed publisher
    ..b>Yohimbine, an ?2 adrenoceptor antagonist, has recently been developed as a carbon-11 [11C]-labeled radioligand for ..
  9. Giampreti A, Lonati D, Locatelli C, Rocchi L, Campailla M. Acute neurotoxicity after yohimbine ingestion by a body builder. Clin Toxicol (Phila). 2009;47:827-9 pubmed publisher
    b>Yohimbine is an alkaloid obtained from the Corynanthe yohimbe tree and other biological sources...

More Information

Publications62

  1. Cippitelli A, Damadzic R, Hansson A, Singley E, Sommer W, ESKAY R, et al. Neuropeptide Y (NPY) suppresses yohimbine-induced reinstatement of alcohol seeking. Psychopharmacology (Berl). 2010;208:417-26 pubmed publisher
    ..endogenous anti-stress mediator, blocks reinstatement of alcohol-seeking induced by the pharmacological stressor yohimbine. NPY [5.0 or 10...
  2. Morris R, Bouton M. The effect of yohimbine on the extinction of conditioned fear: a role for context. Behav Neurosci. 2007;121:501-14 pubmed
    Six experiments with rat subjects examined the effect of yohimbine, an alpha-2 adrenergic autoreceptor antagonist, on the extinction of conditioned fear to a tone...
  3. Adeniyi A, Brindley G, Pryor J, Ralph D. Yohimbine in the treatment of orgasmic dysfunction. Asian J Androl. 2007;9:403-7 pubmed
    To study the effect of yohimbine in the treatment of men with orgasmic dysfunction. A 20-mg dose of yohimbine was first given to 29 men with orgasmic dysfunction of different aetiology in the clinic...
  4. Kupferschmidt D, Tribe E, Erb S. Effects of repeated yohimbine on the extinction and reinstatement of cocaine seeking. Pharmacol Biochem Behav. 2009;91:473-80 pubmed publisher
    Acute exposure to the pharmacological stressor yohimbine (YOH) reinstates drug seeking in rats...
  5. Vasa R, Pine D, Masten C, Vythilingam M, Collin C, Charney D, et al. Effects of yohimbine and hydrocortisone on panic symptoms, autonomic responses, and attention to threat in healthy adults. Psychopharmacology (Berl). 2009;204:445-55 pubmed publisher
    ..The objective of this paper is to examine the effects of exogenous yohimbine and hydrocortisone, as well as their combination (Y + H), on panic symptoms and attention to social threat cues...
  6. Alonso E, Garrido E, Díez Fernández C, Perez Garcia C, Herradon G, Ezquerra L, et al. Yohimbine prevents morphine-induced changes of glial fibrillary acidic protein in brainstem and alpha2-adrenoceptor gene expression in hippocampus. Neurosci Lett. 2007;412:163-7 pubmed
    The alpha(2)-adrenoceptor antagonist yohimbine is known to oppose to several pharmacological effects of opioid drugs, but the consequences and the mechanisms involved remain to be clearly established...
  7. Majczynski H, Cabaj A, Sławińska U, Górska T. Intrathecal administration of yohimbine impairs locomotion in intact rats. Behav Brain Res. 2006;175:315-22 pubmed
    The effects of upper lumbar level intrathecal injection of yohimbine, an alpha2-noradrenergic antagonist, on overground locomotion in intact rats was studied...
  8. Nair S, Gray S, Ghitza U. Role of food type in yohimbine- and pellet-priming-induced reinstatement of food seeking. Physiol Behav. 2006;88:559-66 pubmed
    ..The anxiogenic drug yohimbine reinstates palatable food seeking in a rat relapse model: a role of CRF(1) receptors...
  9. Wang Y, Li H, Wang H, Peng X, Wang Y, Lu D, et al. Pretreatment with berberine and yohimbine protects against LPS-induced myocardial dysfunction via inhibition of cardiac I-[kappa]B[alpha] phosphorylation and apoptosis in mice. Shock. 2011;35:322-8 pubmed publisher
    ..that pretreatment with berberine (Ber) protected against the lethality induced by LPS, which was enhanced by yohimbine, an [alpha]2-adrenergic receptor antagonist, and Ber combined with yohimbine also improved survival in mice ..
  10. Yeung M, Lu L, Hughes A, Treit D, Dickson C. FG7142, yohimbine, and ?CCE produce anxiogenic-like effects in the elevated plus-maze but do not affect brainstem activated hippocampal theta. Neuropharmacology. 2013;75:47-52 pubmed publisher
    ..CCE), and one ?2 noradrenergic receptor antagonist, 17?-hydroxy-yohimban-16?-carboxylic acid methyl ester (yohimbine) as pharmacological probes to assess the construct validity of the theta model...
  11. Moreira T, Takakura A, Menani J, Colombari E. Involvement of central alpha1- and alpha2-adrenoceptors on cardiovascular responses to moxonidine. Eur J Pharmacol. 2007;563:164-71 pubmed
    ..Pre-treatment with the selective alpha2-adrenoceptor antagonist yohimbine (80, 160 and 320 nmol) injected into the 4th ventricle attenuated the hypotension (-32+/-5, -25+/-4 and -12+/-6 ..
  12. Banihashemi L, Rinaman L. Noradrenergic inputs to the bed nucleus of the stria terminalis and paraventricular nucleus of the hypothalamus underlie hypothalamic-pituitary-adrenal axis but not hypophagic or conditioned avoidance responses to systemic yohimbine. J Neurosci. 2006;26:11442-53 pubmed
    The alpha2 adrenoceptor antagonist yohimbine (YO) increases transmitter release from adrenergic/noradrenergic (NA) neurons...
  13. Ehlert U, Erni K, Hebisch G, Nater U. Salivary alpha-amylase levels after yohimbine challenge in healthy men. J Clin Endocrinol Metab. 2006;91:5130-3 pubmed
    ..aim of this study was to assess cardiovascular effects and sAA and catecholamine secretion after iv injection of yohimbine. We conducted a randomized double-blind placebo-controlled study at an academic research unit...
  14. Cai L, Bakalli H, Rinaman L. Yohimbine anxiogenesis in the elevated plus maze is disrupted by bilaterally disconnecting the bed nucleus of the stria terminalis from the central nucleus of the amygdala. Neuroscience. 2012;223:200-8 pubmed publisher
    The ?2 adrenergic receptor antagonist yohimbine (YO) is a sympathomimetic drug that crosses the blood-brain barrier after systemic administration...
  15. Anker J, Carroll M. Sex differences in the effects of allopregnanolone on yohimbine-induced reinstatement of cocaine seeking in rats. Drug Alcohol Depend. 2010;107:264-7 pubmed publisher
    ..cocaine seeking and on an animal model of stress-induced relapse by administering the pharmacological stressor yohimbine. An additional goal was to examine possible sex-specific treatment effects of the progesterone metabolite, ..
  16. Sun H, Green T, Theobald D, Birnbaum S, Graham D, Zeeb F, et al. Yohimbine increases impulsivity through activation of cAMP response element binding in the orbitofrontal cortex. Biol Psychiatry. 2010;67:649-56 pubmed publisher
    ..Norepinephrine is heavily implicated in responses to stress, and the alpha(2) antagonist yohimbine is used clinically to study this aspect of the stress response...
  17. Zhang H, Wang H, Lu D, Qi R, Wang Y, Yan Y, et al. Berberine inhibits cytosolic phospholipase A2 and protects against LPS-induced lung injury and lethality independent of the alpha2-adrenergic receptor in mice. Shock. 2008;29:617-22 pubmed publisher
    ..b>Yohimbine, an alpha2-adrenergic receptor antagonist, did not antagonize these actions of Ber...
  18. Umhau J, Schwandt M, Usala J, Geyer C, Singley E, George D, et al. Pharmacologically induced alcohol craving in treatment seeking alcoholics correlates with alcoholism severity, but is insensitive to acamprosate. Neuropsychopharmacology. 2011;36:1178-86 pubmed publisher
    ..We evaluated two pharmacological challenges, the ?(2)-adrenergic antagonist yohimbine, which reinstates alcohol seeking in rats, and the serotonergic compound meta-chlorophenylpiperazine (mCPP), ..
  19. Kearney T, Tu N, Haller C. Adverse drug events associated with yohimbine-containing products: a retrospective review of the California Poison Control System reported cases. Ann Pharmacother. 2010;44:1022-9 pubmed publisher
    ..b>Yohimbine is an alpha(2)-antagonist available in both prescription and herbal supplement products...
  20. Richards J, Simms J, Bartlett S. Conditioned cues and yohimbine induce reinstatement of beer and near-beer seeking in Long-Evans rats. Addict Biol. 2009;14:144-51 pubmed publisher
    ..We have determined that reward-associated cues and/or yohimbine will induce reinstatement of beer and near-beer seeking in a similar manner to that seen for 10% ethanol and ..
  21. Zhang F, Feng X, Dong R, Wang H, Liu J, Li W, et al. Effects of clonidine on bilateral pain behaviors and inflammatory response in rats under the state of neuropathic pain. Neurosci Lett. 2011;505:254-9 pubmed publisher
    ..p.; PSNL with clonidine (0.2mg/kg) or saline, i.p.; PSNL with yohimbine (2mg/kg) followed by clonidine (0.2mg/kg), i.p.; and PSNL with naloxone (0.3mg/kg) followed by clonidine (0...
  22. Wang Y, Yu X, Wang F, Wang Y, Wang Y, Li H, et al. Yohimbine promotes cardiac NE release and prevents LPS-induced cardiac dysfunction via blockade of presynaptic ?2A-adrenergic receptor. PLoS ONE. 2013;8:e63622 pubmed publisher
    ..We have recently demonstrated that ?2-adrenoceptor (AR) antagonist, yohimbine (YHB), attenuates lipopolysaccharide (LPS)-induced myocardial depression...
  23. Chen Q, Li P, Zhang Z, Li K, Liu J, Li Q. Analysis of yohimbine alkaloid from Pausinystalia yohimbe by non-aqueous capillary electrophoresis and gas chromatography-mass spectrometry. J Sep Sci. 2008;31:2211-8 pubmed publisher
    ..yohimbe were first examined by GC-MS and the major alkaloids were identified. The quantitation of yohimbine was then accomplished by non-aqueous CE (NACE) with diode array detection...
  24. Fletcher P, Rizos Z, Sinyard J, Tampakeras M, Higgins G. The 5-HT2C receptor agonist Ro60-0175 reduces cocaine self-administration and reinstatement induced by the stressor yohimbine, and contextual cues. Neuropsychopharmacology. 2008;33:1402-12 pubmed
    ..with repeated treatment, and whether Ro60-0175 altered reinstatement induced by the pharmacological stressor yohimbine, or by the context in which self-administration occurred. In Experiment 1, Ro60-0175 (1 mg/kg, s.c...
  25. Talukder M, Hikasa Y, Takahashi H, Sato K, Matsuu A. Antagonistic effects of atipamezole and yohimbine on medetomidine-induced diuresis in healthy dogs. Can J Vet Res. 2009;73:260-70 pubmed
    This study aimed to investigate and compare the antagonistic effects of atipamezole and yohimbine on medetomidine-induced diuresis in healthy dogs. Five dogs were used repeatedly in each of 8 groups. One group was not medicated...
  26. Nielsen C, Simms J, Bito Onon J, Li R, Ananthan S, Bartlett S. The delta opioid receptor antagonist, SoRI-9409, decreases yohimbine stress-induced reinstatement of ethanol-seeking. Addict Biol. 2012;17:224-34 pubmed publisher
    ..The objective of this study was to determine the role of DOP-Rs in yohimbine-stress-induced reinstatement of ethanol-seeking...
  27. Gozzi A, Lepore S, Vicentini E, Merlo Pich E, Bifone A. Differential effect of orexin-1 and CRF-1 antagonism on stress circuits: a fMRI study in the rat with the pharmacological stressor Yohimbine. Neuropsychopharmacology. 2013;38:2120-30 pubmed publisher
    ..The alpha-2 adrenoreceptor antagonist yohimbine represents an attractive experimental tool owing to its well-documented stress-inducing properties in humans and ..
  28. Feltenstein M, See R. Potentiation of cue-induced reinstatement of cocaine-seeking in rats by the anxiogenic drug yohimbine. Behav Brain Res. 2006;174:1-8 pubmed
    ..Here, we assessed the effects of the anxiogenic alpha2-noradrenergic receptor antagonist, yohimbine, on reinstatement of cocaine-seeking in rats either in the presence or absence of cocaine-associated cues...
  29. Bloomer R, Canale R, Blankenship M, Hammond K, Fisher Wellman K, Schilling B. Effect of the dietary supplement Meltdown on catecholamine secretion, markers of lipolysis, and metabolic rate in men and women: a randomized, placebo controlled, cross-over study. Lipids Health Dis. 2009;8:32 pubmed publisher
    ..Meltdown may prove to be an effective intervention strategy for fat loss, assuming individuals are normotensive and their treatment is monitored by a qualified health care professional. ..
  30. Talukder H, Hikasa Y, Matsuu A, Kawamura H. Antagonistic effects of atipamezole and yohimbine on xylazine-induced diuresis in healthy dogs. J Vet Med Sci. 2009;71:539-48 pubmed
    The aim of this study was to investigate and compare the antagonistic effects of atipamezole and yohimbine on xylazine-induced diuresis in healthy dogs...
  31. Ezquerra L, Perez Garcia C, Garrido E, Díez Fernández C, Deuel T, Alguacil L, et al. Morphine and yohimbine regulate midkine gene expression in the rat hippocampus. Eur J Pharmacol. 2007;557:147-50 pubmed
    ..pathway, an effect that is prevented when opioids are coadministered with the alpha2-adrenoceptor antagonist yohimbine. The present work tries to examine a possible link between yohimbine reversal of morphine effects and ..
  32. Simms J, Haass Koffler C, Bito Onon J, Li R, Bartlett S. Mifepristone in the central nucleus of the amygdala reduces yohimbine stress-induced reinstatement of ethanol-seeking. Neuropsychopharmacology. 2012;37:906-18 pubmed publisher
    ..of stable baseline responding, we examined the effects of mifepristone on maintained responding and yohimbine-induced increases in responding for ethanol and sucrose...
  33. Zheng H, Rinaman L. Yohimbine anxiogenesis in the elevated plus maze requires hindbrain noradrenergic neurons that target the anterior ventrolateral bed nucleus of the stria terminalis. Eur J Neurosci. 2013;37:1340-9 pubmed publisher
    The ?2 adrenergic receptor antagonist yohimbine (YO) increases transmitter release from noradrenergic (NA) terminals in cortical and subcortical brain regions, including the bed nucleus of the stria terminalis (BST)...
  34. Zhang Y, Huang Z, Ding L, Yan H, Wang M, Zhu S. Simultaneous determination of yohimbine, sildenafil, vardenafil and tadalafil in dietary supplements using high-performance liquid chromatography-tandem mass spectrometry. J Sep Sci. 2010;33:2109-14 pubmed publisher
    A simple and sensitive method was developed for determination of illegal adulterants (yohimbine, sildenafil, vardenafil and tadalafil) in dietary supplements by HPLC-MS/MS...
  35. Buffalari D, See R. Inactivation of the bed nucleus of the stria terminalis in an animal model of relapse: effects on conditioned cue-induced reinstatement and its enhancement by yohimbine. Psychopharmacology (Berl). 2011;213:19-27 pubmed publisher
    ..Recent evidence has shown a strong enhancing effect of yohimbine stress on subsequent cue-elicited reinstatement; however, there has been no examination of the neural substrates ..
  36. Simms J, Richards J, Mill D, Kanholm I, Holgate J, Bartlett S. Induction of multiple reinstatements of ethanol- and sucrose-seeking behavior in Long-Evans rats by the ?-2 adrenoreceptor antagonist yohimbine. Psychopharmacology (Berl). 2011;218:101-10 pubmed publisher
    ..We examined the effects of multiple reinstatement sessions using the pharmacological stressor, yohimbine, in ethanol- and sucrose-seeking rats in order to develop a more efficient model of stress-induced reinstatement...
  37. Crespi F. Anxiolytics antagonize yohimbine-induced central noradrenergic activity: a concomitant in vivo voltammetry-electrophysiology model of anxiety. J Neurosci Methods. 2009;180:97-105 pubmed publisher
    ..Furthermore, the noradrenergic alpha-2 receptor antagonist yohimbine (YOH) increases noradrenaline- (NA) cell firing and release in discrete brain areas involved in the modulation ..
  38. Nair S, Navarre B, Cifani C, Pickens C, Bossert J, Shaham Y. Role of dorsal medial prefrontal cortex dopamine D1-family receptors in relapse to high-fat food seeking induced by the anxiogenic drug yohimbine. Neuropsychopharmacology. 2011;36:497-510 pubmed publisher
    ..In rats, the anxiogenic drug yohimbine, which causes stress-like responses in both humans and nonhumans, reinstates food seeking in a relapse model...
  39. Feltenstein M, Henderson A, See R. Enhancement of cue-induced reinstatement of cocaine-seeking in rats by yohimbine: sex differences and the role of the estrous cycle. Psychopharmacology (Berl). 2011;216:53-62 pubmed publisher
    ..for reinstatement of extinguished cocaine-seeking produced by cocaine-paired cues or the stress-activating drug, yohimbine. Male and female Sprague-Dawley rats self-administered intravenous cocaine (0...
  40. Bharucha A, Charkoudian N, Andrews C, Camilleri M, Sletten D, Zinsmeister A, et al. Effects of glucagon-like peptide-1, yohimbine, and nitrergic modulation on sympathetic and parasympathetic activity in humans. Am J Physiol Regul Integr Comp Physiol. 2008;295:R874-80 pubmed publisher
    ..oxide synthase (NOS) inhibitor N(G)-monomethyl-l-arginine acetate (l-NMMA), the alpha(2)-adrenergic antagonist yohimbine, or placebo (i.e., saline), alone or in combination...
  41. Brown Z, Kupferschmidt D, Erb S. Reinstatement of cocaine seeking in rats by the pharmacological stressors, corticotropin-releasing factor and yohimbine: role for D1/5 dopamine receptors. Psychopharmacology (Berl). 2012;224:431-40 pubmed publisher
    ..peptide, corticotropin-releasing factor (CRF), and systemic administration of the ?(2)-adrenoceptor antagonist, yohimbine. Despite the widespread use of these stressors, the neurochemical systems mediating their ability to reinstate ..
  42. Dzung Lê A, Funk D, Harding S, Juzytsch W, Fletcher P. The role of noradrenaline and 5-hydroxytryptamine in yohimbine-induced increases in alcohol-seeking in rats. Psychopharmacology (Berl). 2009;204:477-88 pubmed publisher
    ..showed that systemic administration of the prototypical alpha-2 noradrenaline (NA) receptor antagonist yohimbine increases alcohol self-administration and reinstatement...
  43. Shibao C, Okamoto L, Gamboa A, Yu C, Diedrich A, Raj S, et al. Comparative efficacy of yohimbine against pyridostigmine for the treatment of orthostatic hypotension in autonomic failure. Hypertension. 2010;56:847-51 pubmed publisher
    ..residual sympathetic tone that can be engaged to increase blood pressure (BP) with the ?-2 adrenergic antagonist yohimbine. This medication activates sympathetic outflow centrally and unrestrains norepinephrine release from ..
  44. Zhao D, Ren L, Lu H, Zhang X. Potentiation by yohimbine of alpha-adrenoceptor-mediated vasoconstriction in response to clonidine in the rabbit ear vein. Eur J Pharmacol. 2008;589:201-5 pubmed publisher
    ..b>Yohimbine (0.1 and 0...
  45. Jakobsen S, Pedersen K, Smith D, Jensen S, Munk O, Cumming P. Detection of alpha2-adrenergic receptors in brain of living pig with 11C-yohimbine. J Nucl Med. 2006;47:2008-15 pubmed
    ..We developed a radiosynthesis for the alpha(2)-adrenergic antagonist (11)C-yohimbine and characterized its binding in living pigs...
  46. Paqueron X, Li X, Bantel C, Tobin J, Voytko M, Eisenach J. An obligatory role for spinal cholinergic neurons in the antiallodynic effects of clonidine after peripheral nerve injury. Anesthesiology. 2001;94:1074-81 pubmed
  47. Knoll L, Benson R, Bilhartz D, Minich P, Furlow W. A randomized crossover study using yohimbine and isoxsuprine versus pentoxifylline in the management of vasculogenic impotence. J Urol. 1996;155:144-6 pubmed
    We evaluated the efficacy and safety of yohimbine and isoxsuprine or pentoxifylline in the management of vasculogenic erectile dysfunction.
  48. Myers E, Banihashemi L, Rinaman L. The anxiogenic drug yohimbine activates central viscerosensory circuits in rats. J Comp Neurol. 2005;492:426-41 pubmed
    Systemic administration of the alpha(2)-adrenoceptor antagonist yohimbine (YO) activates the HPA stress axis and promotes anxiety in humans and experimental animals...
  49. Tank J, Jordan J, Diedrich A, Obst M, Plehm R, Luft F, et al. Clonidine improves spontaneous baroreflex sensitivity in conscious mice through parasympathetic activation. Hypertension. 2004;43:1042-7 pubmed
    ..8:00 am to 12:00 pm) were compared with measurements after intraperitoneal alpha-2 adrenoceptor blockade (yohimbine 2 mg/kg) and alpha-2 adrenoceptor stimulation (clonidine 1, 10, and 50 mg/kg)...
  50. Takayama H, Ishikawa H, Kitajima M, Aimi N, Aji B. A new 9-methoxyyohimbine-type indole alkaloid from Mitragyna africanus. Chem Pharm Bull (Tokyo). 2004;52:359-61 pubmed
    A new yohimbine-type indole alkaloid (1). was isolated from the stem bark of Mitragyna africanus (WILLD...
  51. Lee B, Tiefenbacher S, Platt D, Spealman R. Pharmacological blockade of alpha2-adrenoceptors induces reinstatement of cocaine-seeking behavior in squirrel monkeys. Neuropsychopharmacology. 2004;29:686-93 pubmed
    ..b>Yohimbine, an alpha(2)-adrenoceptor antagonist, is known to be anxiogenic and induce stress-related responses in humans ..
  52. Wang W, Yuan W, Ren A, Pan Y, Tang C, Su D. Role of I1-imidazoline receptors within the caudal ventrolateral medulla in cardiovascular responses to clonidine in rats. J Cardiovasc Pharmacol. 2003;42:1-9 pubmed
    ..Microinjection of yohimbine (a selective alpha2-adrenoceptor antagonist, 500 pmol/50 nl) into the caudal ventrolateral medulla did not ..
  53. Fuller B, Drake M, Spaulding D, Chaudhry F. Downregulation of tyrosinase activity in human melanocyte cell cultures by yohimbine. J Invest Dermatol. 2000;114:268-76 pubmed
    Treatment of human melanocyte cell cultures with the alpha-2 adrenergic receptor antagonist yohimbine results in a marked down-regulation of tyrosinase activity...