ellagic acid

Summary

Summary: A fused four ring compound occurring free or combined in galls. Isolated from the kino of Eucalyptus maculata Hook and E. Hemipholia F. Muell. Activates Factor XII of the blood clotting system which also causes kinin release; used in research and as a dye.

Top Publications

  1. Lee J, Johnson J, Talcott S. Identification of ellagic acid conjugates and other polyphenolics in muscadine grapes by HPLC-ESI-MS. J Agric Food Chem. 2005;53:6003-10 pubmed
    b>Ellagic acid, ellagic acid glycosides, and ellagitannins found in various fruits and nuts, including muscadine grape, are reported to have potential health-promoting benefits and antioxidant properties...
  2. Atkinson C, Dodds P, Ford Y, Le Mière J, Taylor J, Blake P, et al. Effects of cultivar, fruit number and reflected photosynthetically active radiation on Fragaria x ananassa productivity and fruit ellagic acid and ascorbic acid concentrations. Ann Bot. 2006;97:429-41 pubmed
    A number of strawberry varieties were surveyed for their total ellagic acid concentration, and attempts were made to determine if ellagic acid and ascorbic acid concentrations of two strawberry cultivars could be increased by polythene ..
  3. Munagala R, Aqil F, Vadhanam M, Gupta R. MicroRNA 'signature' during estrogen-mediated mammary carcinogenesis and its reversal by ellagic acid intervention. Cancer Lett. 2013;339:175-84 pubmed publisher
    ..Furthermore, ellagic acid, which inhibited E2-induced mammary tumorigenesis in our previous study, reversed the dysregulation of miR-375, ..
  4. González Barrio R, Truchado P, Ito H, Espín J, Tomas Barberan F. UV and MS identification of Urolithins and Nasutins, the bioavailable metabolites of ellagitannins and ellagic acid in different mammals. J Agric Food Chem. 2011;59:1152-62 pubmed publisher
    Urolithins are microbial metabolites produced from ellagic acid after the intake of dietary ellagitannins by different animals...
  5. Gonzalez Sarrias A, Giménez Bastida J, García Conesa M, Gómez Sánchez M, García Talavera N, Gil Izquierdo A, et al. Occurrence of urolithins, gut microbiota ellagic acid metabolites and proliferation markers expression response in the human prostate gland upon consumption of walnuts and pomegranate juice. Mol Nutr Food Res. 2010;54:311-22 pubmed publisher
    ..Our aim was to assess whether ETs or their metabolites ellagic acid and urolithins reach the human prostate upon consumption of ET-rich foods and to evaluate the effect on the ..
  6. Girish C, Koner B, Jayanthi S, Ramachandra Rao K, Rajesh B, Pradhan S. Hepatoprotective activity of picroliv, curcumin and ellagic acid compared to silymarin on paracetamol induced liver toxicity in mice. Fundam Clin Pharmacol. 2009;23:735-45 pubmed publisher
    ..Present study attempts to evaluate the hepatoprotective activity of picroliv, curcumin and ellagic acid in comparison to silymarin using paracetamol (PCM) induced acute liver damage...
  7. Devipriya N, Sudheer A, Vishwanathan P, Menon V. Modulatory potential of ellagic acid, a natural plant polyphenol on altered lipid profile and lipid peroxidation status during alcohol-induced toxicity: a pathohistological study. J Biochem Mol Toxicol. 2008;22:101-12 pubmed publisher
    ..b>Ellagic acid (EA), a polyphenolic compound widely distributed in fruits and nuts, has been reported to scavenge free ..
  8. Whitley A, Stoner G, Darby M, Walle T. Intestinal epithelial cell accumulation of the cancer preventive polyphenol ellagic acid--extensive binding to protein and DNA. Biochem Pharmacol. 2003;66:907-15 pubmed
    b>Ellagic acid (EA), a polyphenol present in many berries, has been demonstrated to be preventive of esophageal cancer in animals both at the initiation and promotion stages...
  9. Rani U, Kesavan R, Ganugula R, Avaneesh T, Kumar U, Reddy G, et al. Ellagic acid inhibits PDGF-BB-induced vascular smooth muscle cell proliferation and prevents atheroma formation in streptozotocin-induced diabetic rats. J Nutr Biochem. 2013;24:1830-9 pubmed publisher
    ..In the present study, we determined the ability of ellagic acid (EA) to prevent platelet-derived growth factor-BB (PDGF-BB)-induced proliferation of primary cultures of rat ..

Scientific Experts

More Information

Publications62

  1. Girish C, Raj V, Arya J, Balakrishnan S. Involvement of the GABAergic system in the anxiolytic-like effect of the flavonoid ellagic acid in mice. Eur J Pharmacol. 2013;710:49-58 pubmed publisher
    Anxiolytic-like effects of dietary flavonoids are relatively well known. Ellagic acid is a naturally occurring flavonoid compound which is abundant in many plants and fruits...
  2. Fracassetti D, Costa C, Moulay L, Tomas Barberan F. Ellagic acid derivatives, ellagitannins, proanthocyanidins and other phenolics, vitamin C and antioxidant capacity of two powder products from camu-camu fruit (Myrciaria dubia). Food Chem. 2013;139:578-88 pubmed publisher
    ..95 mg/100 g vs. 48.54 mg/100 g). In both products the flavonol myricetin and conjugates, ellagic acid and conjugates and ellagitannins were detected...
  3. Abe L, Lajolo F, Genovese M. Potential dietary sources of ellagic acid and other antioxidants among fruits consumed in Brazil: jabuticaba (Myrciaria jaboticaba (Vell.) Berg). J Sci Food Agric. 2012;92:1679-87 pubmed publisher
    The objectives of this study were (1) to evaluate the content of ellagic acid in fruits consumed by the Brazilian population, including native ones; (2) to further characterize rich sources in relation to ascorbic acid, phenolics contents ..
  4. Makino Wakagi Y, Yoshimura Y, Uzawa Y, Zaima N, Moriyama T, Kawamura Y. Ellagic acid in pomegranate suppresses resistin secretion by a novel regulatory mechanism involving the degradation of intracellular resistin protein in adipocytes. Biochem Biophys Res Commun. 2012;417:880-5 pubmed publisher
    ..We also found that ellagic acid (EA), a main component of pomegranate, had the same effects on the secretion and intracellular protein level of ..
  5. Kim S, Gaber M, Zawaski J, Zhang F, Richardson M, Zhang X, et al. The inhibition of glioma growth in vitro and in vivo by a chitosan/ellagic acid composite biomaterial. Biomaterials. 2009;30:4743-51 pubmed publisher
    This study has developed a chitosan-based delivery system to locally administer ellagic acid for brain cancer treatment. We fabricated chitosan/ellagic acid composite films with various concentrations of ellagic acid...
  6. Sekiguchi Y, Nakaniwa T, Kinoshita T, Nakanishi I, Kitaura K, Hirasawa A, et al. Structural insight into human CK2alpha in complex with the potent inhibitor ellagic acid. Bioorg Med Chem Lett. 2009;19:2920-3 pubmed publisher
    ..a human CK2 catalytic subunit (referred to as CK2alpha complexed with the ATP-competitive, potent CK2 inhibitor ellagic acid. The inhibitor binds to CK2alpha with a novel binding mode, including water-mediated hydrogen bonds...
  7. Da Silva S, Calgarotto A, Chaar J, Marangoni S. Isolation and characterization of ellagic acid derivatives isolated from Casearia sylvestris SW aqueous extract with anti-PLA(2) activity. Toxicon. 2008;52:655-66 pubmed publisher
    ..sylvestris. In this study, four ellagic acid derivatives from aqueous extracts of C...
  8. Seeram N, Lee R, Heber D. Bioavailability of ellagic acid in human plasma after consumption of ellagitannins from pomegranate (Punica granatum L.) juice. Clin Chim Acta. 2004;348:63-8 pubmed
    b>Ellagic acid (EA) and hydrolyzable ellagitannins (ETs) are dietary polyphenols found in fruits and nuts and implicated with potent antioxidant, anticancer and antiatherosclerotic biological properties...
  9. Vadhanam M, Ravoori S, Aqil F, Gupta R. Chemoprevention of mammary carcinogenesis by sustained systemic delivery of ellagic acid. Eur J Cancer Prev. 2011;20:484-91 pubmed publisher
    ..b>Ellagic acid has been tested in various animal models with mixed results...
  10. Tabopda T, Ngoupayo J, Liu J, Ali M, Khan S, Ngadjui B, et al. Alpha-glucosidase inhibitors ellagic acid derivatives with immunoinhibitory properties from Terminalia superba. Chem Pharm Bull (Tokyo). 2008;56:847-50 pubmed
    Fractionation of stem barks of Terminalia superba yielded two new ellagic acid derivatives, 3,4'-di-O-methylellagic acid 3'-O-beta-D-xylopyranoside (1) and 4'-O-galloy-3,3'-di-O-methylellagic acid 4-O-beta-D-xylopyranoside (2) together ..
  11. Zhao M, Tang S, Marsh J, Shankar S, Srivastava R. Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice. Cancer Lett. 2013;337:210-7 pubmed publisher
    b>Ellagic acid (EA) is a polyphenol found in several plants and fruits. The objectives of this study were to examine the molecular mechanisms by which EA inhibits pancreatic cancer growth in Balb C nude mice...
  12. Yuce A, Atessahin A, Ceribasi A, Aksakal M. Ellagic acid prevents cisplatin-induced oxidative stress in liver and heart tissue of rats. Basic Clin Pharmacol Toxicol. 2007;101:345-9 pubmed
    ..determine the effects on the liver and heart oxidant/antioxidant system and the possible protective effects of ellagic acid on liver and heart toxicity induced by cisplatin. The control group received 0...
  13. Choi Y, Yan G. Ellagic Acid attenuates immunoglobulin E-mediated allergic response in mast cells. Biol Pharm Bull. 2009;32:1118-21 pubmed
    b>Ellagic acid is known to have anti-oxidant, anti-carcinogenic and anti-mutagenic effects. However, roles of ellagic acid in the immediate-type allergic reactions have not yet been investigated...
  14. Yoshimura Y, Nishii S, Zaima N, Moriyama T, Kawamura Y. Ellagic acid improves hepatic steatosis and serum lipid composition through reduction of serum resistin levels and transcriptional activation of hepatic ppara in obese, diabetic KK-A(y) mice. Biochem Biophys Res Commun. 2013;434:486-91 pubmed publisher
    b>Ellagic acid (EA) is a polyphenol found in a wide variety of plant foods that not only exhibits free radical-scavenging activity, but also confers protective effects against liver injury...
  15. Paivarinta E, Pajari A, Törrönen R, Mutanen M. Ellagic acid and natural sources of ellagitannins as possible chemopreventive agents against intestinal tumorigenesis in the Min mouse. Nutr Cancer. 2006;54:79-83 pubmed
    b>Ellagic acid has been shown to have chemopreventive effects in various experimental cancer models...
  16. Kuo M, Ou H, Lee W, Kuo W, Hwang L, Song T, et al. Ellagic acid inhibits oxidized low-density lipoprotein (OxLDL)-induced metalloproteinase (MMP) expression by modulating the protein kinase C-?/extracellular signal-regulated kinase/peroxisome proliferator-activated receptor ?/nuclear factor-?B (PKC-?. J Agric Food Chem. 2011;59:5100-8 pubmed publisher
    ..b>Ellagic acid, a phenolic compound found in fruits and nuts, has potent antioxidant, anti-inflammatory, and anticancerous ..
  17. Tasaki M, Umemura T, Maeda M, Ishii Y, Okamura T, Inoue T, et al. Safety assessment of ellagic acid, a food additive, in a subchronic toxicity study using F344 rats. Food Chem Toxicol. 2008;46:1119-24 pubmed
    b>Ellagic acid is a phenolic acid compound, used as a food additive for its antioxidative properties. Because of its chemical characteristics, use is also to be expected in cosmetics...
  18. Mishra S, Vinayak M. Ellagic acid checks lymphoma promotion via regulation of PKC signaling pathway. Mol Biol Rep. 2013;40:1417-28 pubmed publisher
    ..To investigate this hypothesis we have tested the effect of ellagic acid on these genes in Dalton's lymphoma bearing (DL)...
  19. Kim S, Liu Y, Gaber M, Bumgardner J, Haggard W, Yang Y. Development of chitosan-ellagic acid films as a local drug delivery system to induce apoptotic death of human melanoma cells. J Biomed Mater Res B Appl Biomater. 2009;90:145-55 pubmed publisher
    This study was designed to develop a local chemotherapy device using chitosan as a local drug carrier and ellagic acid (EA) as an anticancer drug. We fabricated chitosan-ellagic acid (Ch-EA) films with concentrations of 0, 0.05, 0.1, 0...
  20. Chatterjee A, Chatterjee S, Das S, Saha A, Chattopadhyay S, Bandyopadhyay S. Ellagic acid facilitates indomethacin-induced gastric ulcer healing via COX-2 up-regulation. Acta Biochim Biophys Sin (Shanghai). 2012;44:565-76 pubmed publisher
    The mechanism of indomethacin-induced gastric ulcer healing by ellagic acid (EA) in experimental mice model is described in our study...
  21. Hseu Y, Chou C, Senthil Kumar K, Fu K, Wang H, Hsu L, et al. Ellagic acid protects human keratinocyte (HaCaT) cells against UVA-induced oxidative stress and apoptosis through the upregulation of the HO-1 and Nrf-2 antioxidant genes. Food Chem Toxicol. 2012;50:1245-55 pubmed publisher
    ..The aim of this study was to investigate the protective role of ellagic acid (25-75 ?M), a natural antioxidant, against UVA (5-20 J/cm(2))-induced oxidative stress and apoptosis in human ..
  22. Na L, Jun Tian L, Qiang Zong Z. Ellagic acid-induced hypercoagulable state in animals: a potentially useful animal hypercoagulable model for evaluation of anticoagulants. Chin Med Sci J. 2010;25:237-42 pubmed
    ..rats, and twenty-four rabbits were randomly and equally divided into control group (saline) and three ellagic acid (EA)-treated groups (low, middle, and high doses)...
  23. Mertens Talcott S, Talcott S, Percival S. Low concentrations of quercetin and ellagic acid synergistically influence proliferation, cytotoxicity and apoptosis in MOLT-4 human leukemia cells. J Nutr. 2003;133:2669-74 pubmed
    ..The objective of this study was to investigate interactions between quercetin and ellagic acid, two polyphenolics that are present predominantly in small fruits, on cell death and proliferation-related ..
  24. Bae J, Choi J, Kang S, Lee Y, Park J, Kang Y. Dietary compound ellagic acid alleviates skin wrinkle and inflammation induced by UV-B irradiation. Exp Dermatol. 2010;19:e182-90 pubmed publisher
    b>Ellagic acid, a polyphenol compound present in berries and pomegranate, has received attention as an agent that may have potential bioactivities preventing chronic diseases...
  25. Fjaeraa C, Nånberg E. Effect of ellagic acid on proliferation, cell adhesion and apoptosis in SH-SY5Y human neuroblastoma cells. Biomed Pharmacother. 2009;63:254-61 pubmed publisher
    b>Ellagic acid, a polyphenolic compound found in berries, fruits and nuts, has been shown to possess growth-inhibiting and apoptosis promoting activities in cancer cell lines in vitro...
  26. Pari L, Sivasankari R. Effect of ellagic acid on cyclosporine A-induced oxidative damage in the liver of rats. Fundam Clin Pharmacol. 2008;22:395-401 pubmed publisher
    ..This study was undertaken to investigate the protective effect of ellagic acid (EA), a polyphenolic compound against CsA-induced liver injury in male Wistar rats...
  27. Edderkaoui M, Odinokova I, Ohno I, Gukovsky I, Go V, Pandol S, et al. Ellagic acid induces apoptosis through inhibition of nuclear factor kappa B in pancreatic cancer cells. World J Gastroenterol. 2008;14:3672-80 pubmed
    To determine the effect of ellagic acid on apoptosis and proliferation in pancreatic cancer cells and to determine the mechanism of the pro-survival effects of ellagic acid...
  28. Taghi Mansouri M, Naghizadeh B, Ghorbanzadeh B, Farbood Y. Central and peripheral antinociceptive effects of ellagic acid in different animal models of pain. Eur J Pharmacol. 2013;707:46-53 pubmed publisher
    The present study was conducted to evaluate the analgesic effects of p.o., i.p., or i.c.v. administration of ellagic acid (EA), and investigate the possible mechanisms underlying the systemic antinociceptive activities in different animal ..
  29. Labrecque L, Lamy S, Chapus A, Mihoubi S, Durocher Y, Cass B, et al. Combined inhibition of PDGF and VEGF receptors by ellagic acid, a dietary-derived phenolic compound. Carcinogenesis. 2005;26:821-6 pubmed
    ..In this study, we report that ellagic acid (EA), a natural polyphenol found in fruits and nuts, inhibits VEGF-induced phosphorylation of VEGFR-2 in ..
  30. Corbett S, Daniel J, Drayton R, Field M, Steinhardt R, Garrett N. Evaluation of the anti-inflammatory effects of ellagic acid. J Perianesth Nurs. 2010;25:214-20 pubmed publisher
    Few studies have investigated the anti-inflammatory properties of ellagic acid and no published studies have examined the effects of ellagic acid in combination with anesthetic adjuvants...
  31. Sakthivel M, Geraldine P, Thomas P. Alterations in the lenticular protein profile in experimental selenite-induced cataractogenesis and prevention by ellagic acid. Graefes Arch Clin Exp Ophthalmol. 2011;249:1201-10 pubmed publisher
    ..This study aimed to evaluate whether ellagic acid, a natural polyphenol with antioxidant properties, prevents alterations in the lenticular protein profile in an ..
  32. Jurenka J. Therapeutic applications of pomegranate (Punica granatum L.): a review. Altern Med Rev. 2008;13:128-44 pubmed
    ..Other potential applications include infant brain ischemia, male infertility, Alzheimer's disease, arthritis, and obesity...
  33. Modi M, Goel T, Das T, Malik S, Suri S, Rawat A, et al. Ellagic acid & gallic acid from Lagerstroemia speciosa L. inhibit HIV-1 infection through inhibition of HIV-1 protease & reverse transcriptase activity. Indian J Med Res. 2013;137:540-8 pubmed
    ..The aim of this study was to evaluate the anti-HIV property of the extracts prepared from the leaves and stems of banaba, and further purification and characterization of the active components...
  34. Devipriya N, Sudheer A, Menon V. Dose-response effect of ellagic acid on circulatory antioxidants and lipids during alcohol-induced toxicity in experimental rats. Fundam Clin Pharmacol. 2007;21:621-30 pubmed
    b>Ellagic acid (EA) is a naturally occurring polyphenolic compound that exhibits antioxidative, anti-inflammatory, anti-hyperlipidaemic and anticarcinogenic activities in a wide range of assays both in vitro and in vivo...
  35. Kassim M, Achoui M, Mustafa M, Mohd M, Yusoff K. Ellagic acid, phenolic acids, and flavonoids in Malaysian honey extracts demonstrate in vitro anti-inflammatory activity. Nutr Res. 2010;30:650-9 pubmed publisher
    ..b>Ellagic acid was the most abundant of the phenolic compounds recorded, with mean concentrations of 3295.83 and 626...
  36. Truchado P, Larrosa M, García Conesa M, Cerdá B, Vidal Guevara M, Tomas Barberan F, et al. Strawberry processing does not affect the production and urinary excretion of urolithins, ellagic acid metabolites, in humans. J Agric Food Chem. 2012;60:5749-54 pubmed publisher
    ..Strawberry polyphenols, and particularly ellagitannins and ellagic acid, have been associated with the health benefits of this berry for humans...
  37. Muthenna P, Akileshwari C, Reddy G. Ellagic acid, a new antiglycating agent: its inhibition of N?-(carboxymethyl)lysine. Biochem J. 2012;442:221-30 pubmed publisher
    ..The present study describes AGE inhibition and the mechanism of action of a new antiglycating agent, EA (ellagic acid), a flavonoid present in many dietary sources...
  38. Malik A, Afaq S, Shahid M, Akhtar K, Assiri A. Influence of ellagic acid on prostate cancer cell proliferation: a caspase-dependent pathway. Asian Pac J Trop Med. 2011;4:550-5 pubmed publisher
    To evaluate the effect of allagic acid treatment on the cell viability of human prostate cancer cells. Ellagic acid (10-100 mol/L) treatment (48 h) of human prostate carcinoma PC3 cells was found to result in a dose-dependent inhibition ..
  39. Aiyer H, Gupta R. Berries and ellagic acid prevent estrogen-induced mammary tumorigenesis by modulating enzymes of estrogen metabolism. Cancer Prev Res (Phila). 2010;3:727-37 pubmed publisher
    To determine whether dietary berries and ellagic acid prevent 17beta-estradiol (E(2))-induced mammary tumors by altering estrogen metabolism, we randomized August-Copenhagen Irish rats (n = 6 per group) into five groups: sham implant + ..
  40. Elkhateeb A, Subeki -, Takahashi K, Matsuura H, Yamasaki M, Yamato O, et al. Anti-babesial ellagic acid rhamnosides from the bark of Elaeocarpus parvifolius. Phytochemistry. 2005;66:2577-80 pubmed
    Bioassay-guided investigation of the bark of Elaeocarpus parvifolius led to the isolation of three new ellagic acid derivatives, 4-O-methylellagic acid 3'-alpha-rhamnoside (2), 4-O-methylellagic acid 3'-(3''-O-acetyl)-alpha-rhamnoside (3),..
  41. Aiyer H, Srinivasan C, Gupta R. Dietary berries and ellagic acid diminish estrogen-mediated mammary tumorigenesis in ACI rats. Nutr Cancer. 2008;60:227-34 pubmed publisher
    ..In this study, we investigated efficacy of dietary berries and ellagic acid to reduce estrogen-mediated mammary tumorigenesis...
  42. Bell C, Hawthorne S. Ellagic acid, pomegranate and prostate cancer -- a mini review. J Pharm Pharmacol. 2008;60:139-44 pubmed publisher
    ..extracts have recently been shown to exhibit antioxidant properties, thought to be due to the action of ellagic acid, the main polyphenol in pomegranate...
  43. Rogerio A, Fontanari C, Borducchi E, Keller A, Russo M, Soares E, et al. Anti-inflammatory effects of Lafoensia pacari and ellagic acid in a murine model of asthma. Eur J Pharmacol. 2008;580:262-70 pubmed
    ..extract of Lafoensia pacari inhibits eosinophilic inflammation induced by Toxocara canis infection, and that ellagic acid is the secondary metabolite responsible for the anti-eosinophilic activity seen in a model of beta-glucan ..
  44. Uzar E, Alp H, Cevik M, Firat U, Evliyaoglu O, Tüfek A, et al. Ellagic acid attenuates oxidative stress on brain and sciatic nerve and improves histopathology of brain in streptozotocin-induced diabetic rats. Neurol Sci. 2012;33:567-74 pubmed publisher
    The aim of this study was to investigate the possible effects of ellagic acid in brain and sciatic nerve tissues of diabetic rats...
  45. Mertens Talcott S, Bomser J, Romero C, Talcott S, Percival S. Ellagic acid potentiates the effect of quercetin on p21waf1/cip1, p53, and MAP-kinases without affecting intracellular generation of reactive oxygen species in vitro. J Nutr. 2005;135:609-14 pubmed
    ..In a previous study, it was demonstrated that quercetin and ellagic acid interacted synergistically in the induction of apoptosis in the human leukemia cell line, MOLT-4...
  46. Gasperotti M, Masuero D, Vrhovsek U, Guella G, Mattivi F. Profiling and accurate quantification of Rubus ellagitannins and ellagic acid conjugates using direct UPLC-Q-TOF HDMS and HPLC-DAD analysis. J Agric Food Chem. 2010;58:4602-16 pubmed publisher
    Accurate quantification and structural characterization of ellagitannins and ellagic acid conjugates in food, beverages, and food supplements are essential starting points for studying their effect on human health...
  47. Yoshimura M, Watanabe Y, Kasai K, Yamakoshi J, Koga T. Inhibitory effect of an ellagic acid-rich pomegranate extract on tyrosinase activity and ultraviolet-induced pigmentation. Biosci Biotechnol Biochem. 2005;69:2368-73 pubmed
    A pomegranate extract (PE) from the rind containing 90% ellagic acid was tested for its skin-whitening effect...
  48. Suzuki N, Masamune A, Kikuta K, Watanabe T, Satoh K, Shimosegawa T. Ellagic acid inhibits pancreatic fibrosis in male Wistar Bonn/Kobori rats. Dig Dis Sci. 2009;54:802-10 pubmed publisher
    ..We have previously shown that ellagic acid, a plant-derived polyphenol found in fruits and nuts, inhibited activation of pancreatic stellate cells, a ..
  49. Cozza G, Gianoncelli A, Bonvini P, Zorzi E, Pasquale R, Rosolen A, et al. Urolithin as a converging scaffold linking ellagic acid and coumarin analogues: design of potent protein kinase CK2 inhibitors. ChemMedChem. 2011;6:2273-86 pubmed publisher
    ..different in silico screening approaches, two potent and selective CK2 inhibitors were identified by our group: ellagic acid, a naturally occurring tannic acid derivative (K(i)=20 nM) and 3,8-dibromo-7-hydroxy-4-methylchromen-2-one (DBC,..
  50. González Barrio R, Edwards C, Crozier A. Colonic catabolism of ellagitannins, ellagic acid, and raspberry anthocyanins: in vivo and in vitro studies. Drug Metab Dispos. 2011;39:1680-8 pubmed publisher
    ..In vitro anaerobic incubation of ellagitannins with fecal suspensions demonstrated conversion to ellagic acid and several urolithins. Fecal suspensions converted 80% of added ellagic acid to urolithins...
  51. Kim S, Nishimoto S, Bumgardner J, Haggard W, Gaber M, Yang Y. A chitosan/beta-glycerophosphate thermo-sensitive gel for the delivery of ellagic acid for the treatment of brain cancer. Biomaterials. 2010;31:4157-66 pubmed publisher
    We report here the development of a chitosan/beta-glycerophosphate(Ch/beta-GP) thermo-sensitive gel to deliver ellagic acid (EA) for cancer treatment...
  52. Buniatian G. Stages of activation of hepatic stellate cells: effects of ellagic acid, an inhibiter of liver fibrosis, on their differentiation in culture. Cell Prolif. 2003;36:307-19 pubmed
    ..against environmental insult, the profile of differentiation of HSC has been examined upon treatment with ellagic acid (EA), a plant-derived antioxidant that shows multiple protective effects during liver disease...
  53. Qiu Z, Zhou B, Jin L, Yu H, Liu L, Liu Y, et al. In vitro antioxidant and antiproliferative effects of ellagic acid and its colonic metabolite, urolithins, on human bladder cancer T24 cells. Food Chem Toxicol. 2013;59:428-37 pubmed publisher
    Urolithins were the metabolites of ellagic acid by intestinal flora in gastrointestinal tract. In previous research, it was found that urolithins could mainly inhibit prostate cancer and colon cancer cell growth...