scopoletin

Summary

Summary: Plant growth factor derived from the root of Scopolia carniolica or Scopolia japonica.

Top Publications

  1. Rollinger J, Hornick A, Langer T, Stuppner H, Prast H. Acetylcholinesterase inhibitory activity of scopolin and scopoletin discovered by virtual screening of natural products. J Med Chem. 2004;47:6248-54 pubmed
    ..In our study, scopoletin (1) and its glucoside scopolin (2) emerged as potential AChE inhibitors by the virtual screening procedure...
  2. Shaw C, Chen C, Hsu C, Chen C, Tsai Y. Antioxidant properties of scopoletin isolated from Sinomonium acutum. Phytother Res. 2003;17:823-5 pubmed
    b>Scopoletin was isolated from Sinomonium acutum and studied using four experimental models designed to assess antioxidant properties...
  3. Ma J, Jones S, Hecht S. A coumarin from Mallotus resinosus that mediates DNA cleavage. J Nat Prod. 2004;67:1614-6 pubmed
    ..b>Scopoletin (1), a simple coumarin, was identified as the active principle responsible for DNA cleavage activity of the ..
  4. Panda S, Kar A. Evaluation of the antithyroid, antioxidative and antihyperglycemic activity of scopoletin from Aegle marmelos leaves in hyperthyroid rats. Phytother Res. 2006;20:1103-5 pubmed
    b>Scopoletin (7-hydroxy-6-methoxy coumarin) was isolated from the leaves of Aegle marmelos and evaluated for its potential to regulate hyperthyroidism, lipid peroxidation and hyperglycemia in levo-thyroxine-induced hyperthyroid rats...
  5. Kai K, Mizutani M, Kawamura N, Yamamoto R, Tamai M, Yamaguchi H, et al. Scopoletin is biosynthesized via ortho-hydroxylation of feruloyl CoA by a 2-oxoglutarate-dependent dioxygenase in Arabidopsis thaliana. Plant J. 2008;55:989-99 pubmed publisher
    ..In this study, scopoletin biosynthesis was explored using Arabidopsis thaliana, which accumulates scopoletin and its beta-glucopyranoside ..
  6. Kai K, Shimizu B, Mizutani M, Watanabe K, Sakata K. Accumulation of coumarins in Arabidopsis thaliana. Phytochemistry. 2006;67:379-86 pubmed
    ..Considerably high levels of scopoletin and its beta-d-glucopyranoside, scopolin, were found in the wild-type roots...
  7. Pan R, Dai Y, Gao X, Lu D, Xia Y. Inhibition of vascular endothelial growth factor-induced angiogenesis by scopoletin through interrupting the autophosphorylation of VEGF receptor 2 and its downstream signaling pathways. Vascul Pharmacol. 2011;54:18-28 pubmed publisher
    Our previous studies revealed that scopoletin, the main bioactive constituent of Erycibe obtusifolia Benth stems, exerted anti-arthritic activity in vivo partly by preventing synovial angiogenesis...
  8. Vialart G, Hehn A, Olry A, Ito K, Krieger C, Larbat R, et al. A 2-oxoglutarate-dependent dioxygenase from Ruta graveolens L. exhibits p-coumaroyl CoA 2'-hydroxylase activity (C2'H): a missing step in the synthesis of umbelliferone in plants. Plant J. 2012;70:460-70 pubmed publisher
    ..feruloyl CoA 6'-hydroxylase, was functionally expressed in Escherichia coli, and converted feruloyl CoA into scopoletin and p-coumaroyl CoA into umbelliferone with equal activity...
  9. Muschietti L, Gorzalczany S, Ferraro G, Acevedo C, Martino V. Phenolic compounds with anti-inflammatory activity from Eupatorium buniifolium. Planta Med. 2001;67:743-4 pubmed
    ..The compounds were identified as 5,7,5'-trihydroxy-3,6,2',4'-tetramethoxyflavone (1), scopoletin (2) and centaureidin (3) which inhibited the edema by 67.3 %, 59.8 % and 49...

More Information

Publications62

  1. Zhang W, Lee J, Kim Y, Kim I, Park J, Myung C. Amelioration of insulin resistance by scopoletin in high-glucose-induced, insulin-resistant HepG2 cells. Horm Metab Res. 2010;42:930-5 pubmed publisher
    Insulin resistance plays an important role in the development of type 2 diabetes mellitus. Scopoletin, a phenolic coumarin, is reported to regulate hyperglycemia and diabetes...
  2. Chong J, Baltz R, Schmitt C, Beffa R, Fritig B, Saindrenan P. Downregulation of a pathogen-responsive tobacco UDP-Glc:phenylpropanoid glucosyltransferase reduces scopoletin glucoside accumulation, enhances oxidative stress, and weakens virus resistance. Plant Cell. 2002;14:1093-107 pubmed
    ..two tobacco salicylic acid- and pathogen-inducible UGTs (TOGTs) that act very efficiently on the hydroxycoumarin scopoletin and on hydroxycinnamic acids...
  3. Adams M, Efferth T, Bauer R. Activity-guided isolation of scopoletin and isoscopoletin, the inhibitory active principles towards CCRF-CEM leukaemia cells and multi-drug resistant CEM/ADR5000 cells, from Artemisia argyi. Planta Med. 2006;72:862-4 pubmed
    ..Bioassay-guided fractionation of the extract led to the isolation of scopoletin and isoscopoletin as the active principles. Their IC50 values were 2.6 and 4.0 microM, respectively...
  4. Liu W, Hua J, Zhou J, Zhang H, Zhu H, Cheng Y, et al. Synthesis and in vitro antitumor activity of novel scopoletin derivatives. Bioorg Med Chem Lett. 2012;22:5008-12 pubmed publisher
    Twenty scopoletin derivatives were developed by a systematic combinatorial chemical approach and their chemical structures were confirmed by MS, IR, (1)H NMR spectra and elemental analysis...
  5. Kim H, Jang S, Kim Y, Chung H, Yun Y, Kang T, et al. Scopoletin suppresses pro-inflammatory cytokines and PGE2 from LPS-stimulated cell line, RAW 264.7 cells. Fitoterapia. 2004;75:261-6 pubmed
    b>Scopoletin (1-50 microg/ml) inhibited the release of PGE2, TNF-alpha, IL-1beta and IL-6 and suppressed the expression of COX-2 in a concentration-dependent manner...
  6. Capra J, Cunha M, Machado D, Zomkowski A, Mendes B, Santos A, et al. Antidepressant-like effect of scopoletin, a coumarin isolated from Polygala sabulosa (Polygalaceae) in mice: evidence for the involvement of monoaminergic systems. Eur J Pharmacol. 2010;643:232-8 pubmed publisher
    ..In this study, we have investigated the possible antidepressant-like effect of scopoletin, a coumarin from Polygala sabulosa in the tail suspension test and forced swimming test...
  7. Lee S, Ding Y, Yan X, Kim Y, Jang H. Scopoletin and scopolin isolated from Artemisia iwayomogi suppress differentiation of osteoclastic macrophage RAW 264.7 cells by scavenging reactive oxygen species. J Nat Prod. 2013;76:615-20 pubmed publisher
    ..b>Scopoletin (1) and scopolin (2) were isolated from this species...
  8. Manuele M, Ferraro G, Barreiro Arcos M, Lopez P, Cremaschi G, Anesini C. Comparative immunomodulatory effect of scopoletin on tumoral and normal lymphocytes. Life Sci. 2006;79:2043-8 pubmed
    ..In this investigation, the activity of scopoletin, a coumarin that has been isolated from different plants and in this case specifically from T. cordata Mill...
  9. Gachon C, Baltz R, Saindrenan P. Over-expression of a scopoletin glucosyltransferase in Nicotiana tabacum leads to precocious lesion formation during the hypersensitive response to tobacco mosaic virus but does not affect virus resistance. Plant Mol Biol. 2004;54:137-46 pubmed
    Nicotiana tabacum Togt encodes a scopoletin glucosyltransferase (UDPglucose:scopoletin O -beta-D-glucosyltrans- ferase, EC 2.4.1...
  10. Silva W, Deraniyagala S, Wijesundera R, Karunanayake E, Priyanka U. Isolation of scopoletin from leaves of Hevea brasiliensis and the effect of scopoletin on pathogens of H. brasiliensis. Mycopathologia. 2002;153:199-202 pubmed
    b>Scopoletin (7-hydroxy-6-methoxy coumarin) which inhibited the conidial germination of Corynespora cassiicola was isolated from the uninfected mature leaves of Hevea brasiliensis...
  11. Mahattanadul S, Ridtitid W, Nima S, Phdoongsombut N, Ratanasuwon P, Kasiwong S. Effects of Morinda citrifolia aqueous fruit extract and its biomarker scopoletin on reflux esophagitis and gastric ulcer in rats. J Ethnopharmacol. 2011;134:243-50 pubmed publisher
    ..quot;Noni", in an aqueous extract preparation (AFE) as used in Thai traditional medicine and its biomarker scopoletin on gastro-esophageal inflammatory models that are related to the claimed pharmacological properties of AFE and/..
  12. Liu X, Zhang L, Fu X, Chen K, Qian B. Effect of scopoletin on PC3 cell proliferation and apoptosis. Acta Pharmacol Sin. 2001;22:929-33 pubmed
    To investigate the effect of scopoletin on cell proliferation and apoptosis of PC3 cells. Cell growth curve, MTT assay, and acid phosphatase activity (ACP) were used to determine cell proliferation...
  13. Fourcroy P, Sisó Terraza P, Sudre D, Savirón M, Reyt G, Gaymard F, et al. Involvement of the ABCG37 transporter in secretion of scopoletin and derivatives by Arabidopsis roots in response to iron deficiency. New Phytol. 2014;201:155-67 pubmed publisher
  14. Carpinella M, Ferrayoli C, Palacios S. Antifungal synergistic effect of scopoletin, a hydroxycoumarin isolated from Melia azedarach L. fruits. J Agric Food Chem. 2005;53:2922-7 pubmed
    In the continuous search for antifungal compounds from plants, the hydroxycoumarin scopoletin (1) was isolated from seed kernels of Melia azedarach L...
  15. Kim E, Kwon K, Shin B, Seo E, Lee Y, Kim J, et al. Scopoletin induces apoptosis in human promyeloleukemic cells, accompanied by activations of nuclear factor kappaB and caspase-3. Life Sci. 2005;77:824-36 pubmed
    b>Scopoletin (6-methoxy-7-hydroxycoumarin) is a phenolic coumarin and a member of the phytoalexins. In this study we investigated whether scopoletin caused apoptosis in HL-60 promyelocytic cells and, if so, by what mechanisms...
  16. Yun B, Lee I, Ryoo I, Yoo I. Coumarins with monoamine oxidase inhibitory activity and antioxidative coumarino-lignans from Hibiscus syriacus. J Nat Prod. 2001;64:1238-40 pubmed
    A previously undescribed coumarin and a new coumarino-lignan, together with the known compounds scopoletin and cleomiscosins A, C, and D, have been isolated from the root bark of Hibiscus syriacus, and their structures were assigned on ..
  17. Moon P, Lee B, Jeong H, An H, Park S, Kim H, et al. Use of scopoletin to inhibit the production of inflammatory cytokines through inhibition of the IkappaB/NF-kappaB signal cascade in the human mast cell line HMC-1. Eur J Pharmacol. 2007;555:218-25 pubmed
    b>Scopoletin (6-methoxy-7-hydroxycoumarin) is a coumarin compound and a pharmacologically active agent that has been isolated from several plant species...
  18. Grosskinsky D, Naseem M, Abdelmohsen U, Plickert N, Engelke T, Griebel T, et al. Cytokinins mediate resistance against Pseudomonas syringae in tobacco through increased antimicrobial phytoalexin synthesis independent of salicylic acid signaling. Plant Physiol. 2011;157:815-30 pubmed publisher
    ..and up-regulated synthesis of the two major antimicrobial phytoalexins in tobacco (Nicotiana tabacum), scopoletin and capsidiol...
  19. Ding Z, Dai Y, Wang Z. Hypouricemic action of scopoletin arising from xanthine oxidase inhibition and uricosuric activity. Planta Med. 2005;71:183-5 pubmed
    b>Scopoletin exhibited an immediate and dose-dependent hypouricemic effect after intraperitoneal administration (50, 100, 200 mg/kg) in hyperuricemic mice induced by potassium oxonate; however, it did not affect the serum uric acid level in ..
  20. Pan R, Gao X, Li Y, Xia Y, Dai Y. Anti-arthritic effect of scopoletin, a coumarin compound occurring in Erycibe obtusifolia Benth stems, is associated with decreased angiogenesis in synovium. Fundam Clin Pharmacol. 2010;24:477-90 pubmed publisher
    b>Scopoletin is the main constituent of coumarin found in the stems of Erycibe obtusifolia Benth, a traditional Chinese medicine used in the treatment of rheumatoid arthritis...
  21. Tao S, Gao G, Qi S, Li Q, Zhang S. [Studies on the chemical constituents of Scyphiphora hydrophyllacea (II)]. Zhong Yao Cai. 2009;32:712-4 pubmed
    ..All of these six compounds are isolated from Scyphiphora hydrophyllacea for the first time. ..
  22. Nima S, Kasiwong S, Ridtitid W, Thaenmanee N, Mahattanadul S. Gastrokinetic activity of Morinda citrifolia aqueous fruit extract and its possible mechanism of action in human and rat models. J Ethnopharmacol. 2012;142:354-61 pubmed publisher
    ..AFE produced a definite contractile response of a rat gastric fundus strip with a dose dependency. Scopoletin at the same equivalent dose present in AFE elicited a concentration-dependent contraction that amounted to 45% ..
  23. Prange A, Bartsch M, Meiners J, Serek M, Winkelmann T. Interspecific somatic hybrids between Cyclamen persicum and C. coum, two sexually incompatible species. Plant Cell Rep. 2012;31:723-35 pubmed publisher
    ..Heterofusion was detected by double fluorescent staining with fluorescein diacetate and scopoletin. The highest heterofusion frequencies (of about 5%) resulted from a protocol using a protoplast density of 1 × ..
  24. Thoma I, Loeffler C, Sinha A, Gupta M, Krischke M, Steffan B, et al. Cyclopentenone isoprostanes induced by reactive oxygen species trigger defense gene activation and phytoalexin accumulation in plants. Plant J. 2003;34:363-75 pubmed
    ..We propose that phytoprostanes are components of an oxidant-injury-sensing, archaic signaling system that serves to induce several plant defense mechanisms. ..
  25. Obasi S, Obidoa O. Comparative effects of scopoletin and aflatoxin B1 on bovine hepatic mitochondrial respiration in vitro. Z Naturforsch C. 1997;52:680-6 pubmed
    A comparative study of the in vitro effects of the coumarin compounds, scopoletin and aflatoxin B1 (AFB1), on bovine (Bos indicus) hepatic mitochondrial respiration was carried out polarographically, using isocitrate -NAD+ (3 - site), ..
  26. Noh J, Gang G, Kim Y, Yang K, Hwang J, Lee H, et al. Antioxidant effects of the chestnut (Castanea crenata) inner shell extract in t-BHP-treated HepG2 cells, and CCl4- and high-fat diet-treated mice. Food Chem Toxicol. 2010;48:3177-83 pubmed publisher
    ..To determine the active compound of CISE, the fractionation of CISE has been conducted and scoparone and scopoletin were identified as main compounds...
  27. Yin Y, Shen Z, Kong L. [Chemical constituents from the tubers of Ipomoea batata]. Zhong Yao Cai. 2012;35:913-7 pubmed
    ..6 compounds were identified from the CHCl3 extract as Batatinoside I (1), citrusin C(2), octadecyl caffeate (3), beta-amyrin acetate (4), caffeic acid (5), scopoletin (6). Compound 1 is isolated from Ipomoea batata for the first time.
  28. Monsef Esfahani H, Amini M, Goodarzi N, Saiedmohammadi F, Hajiaghaee R, Faramarzi M, et al. Coumarin compounds of Biebersteinia multifida roots show potential anxiolytic effects in mice. Daru. 2013;21:51 pubmed publisher
    ..Traditional preparations of the root of Biebersteinia multifida DC (Geraniaceae), a native medicinal plant of Irano-Turanian floristic region, have been used for the treatment of phobias as anxiolytic herbal preparation...
  29. Lee H, Yang G, Choi J, Lee J. Suppression of Primary Splenocyte Proliferation by Artemisia capillaris and Its Components. Toxicol Res. 2017;33:283-290 pubmed publisher
    ..and adaptive immune cell activation by Artemisia capillaris and its components (ursolic acid, hyperoside, scopoletin, and scopolin)...
  30. Zhou Y, Chen F, Li Z. [Prediction of eluotropic sequence of solutes in countercurrent chromatography]. Se Pu. 2002;20:526-7 pubmed
    ..The establishment of a method for prediction will be helpful for the selection of non-electrolyte solvent systems in CCC. ..
  31. Shimizu B, Miyagawa H, Ueno T, Sakata K, Watanabe K, Ogawa K. Morning glory systemically accumulates scopoletin and scopolin after interaction with Fusarium oxysporum. Z Naturforsch C. 2005;60:83-90 pubmed
    ..analysis of the extract from tissues of morning glory cuttings after NPF treatment showed a quicker induction of scopoletin and scopolin synthesis than that seen in the control cuttings...
  32. Liu S, Zainuddin I, Vanderschuren H, Doughty J, Beeching J. RNAi inhibition of feruloyl CoA 6'-hydroxylase reduces scopoletin biosynthesis and post-harvest physiological deterioration in cassava (Manihot esculenta Crantz) storage roots. Plant Mol Biol. 2017;94:185-195 pubmed publisher
    ..together with the accumulation of secondary metabolites including phenolic compounds, of which the coumarin scopoletin (7-hydroxy-6-methoxy-2H-1-benzopyran-2-one) is the most abundant...
  33. Wang Q, Zhang C, Zhang M, Wang Z. [Study on chemical constituents in roots and rhizomes of Ligularia duciforms II]. Zhongguo Zhong Yao Za Zhi. 2008;33:1018-20 pubmed
    ..To study the chemical constituents in roots and rhizomes of Ligularia duciforms...
  34. Zhao Y, Liu F, Lou H. [Studies on the chemical constituents of Solanum nigrum]. Zhong Yao Cai. 2010;33:555-6 pubmed
    ..compounds were isolated and identified as (+)-pinoresinol (I), (+)-syringaresinol (II), (+)-medioresinol (III), scopoletin (IV), tetracosanoic acid (V) and beta-sitosterol (VI)...
  35. Kim B, Lee Y, Hur H, Lim Y, Ahn J. Production of three O-methhylated esculetins with Escherichia coli expressing O-methyltransferase from poplar. Biosci Biotechnol Biochem. 2006;70:1269-72 pubmed
    ..HPLC analysis of reaction products revealed three peaks corresponding to isoscopoletin, scopoletin, and scoparone, and their structures were determined using NMR. Biotransformation of esculetin with E...
  36. Cheng A, Cheng Y, Chang T. Scopoletin attenuates allergy by inhibiting Th2 cytokines production in EL-4 T cells. Food Funct. 2012;3:886-90 pubmed publisher
    b>Scopoletin is an antioxidant found in certain weedy plants. It exerts anti-inflammatory, anti-allergic, and anti-diabetic activities. It remains unknown whether scopoletin regulates T helper (Th) cells, including Th 1 and Th 2 cells...
  37. Iizuka Y, Kato R, Shibasaki Kitakawa N, Yonemoto T. Combination of extractive solvent addition and immobilization culture for continuous production of scopoletin by tobacco cells. Biotechnol Prog. 2005;21:603-7 pubmed
    Extractive solvent addition was combined with immobilization cultures of Nicotiana tabacum cells to produce scopoletin. Using various solvents, the partition coefficients of scopoletin between the solvent and water phases and the solvent ..
  38. Lambert M, Staerk D, Hansen S, Jaroszewski J. HPLC-SPE-NMR hyphenation in natural products research: optimization of analysis of Croton membranaceus extract. Magn Reson Chem. 2005;43:771-5 pubmed
    ..The trapping efficiency of scopoletin (1), the major extract constituent, was much higher on a GP (general phase, a polystyrene-type polymer) SPE ..
  39. Jenkins R, Palausky A, Counts R, Bayne C, Dindal A, Guerin M. Exposure to environmental tobacco smoke in sixteen cities in the United States as determined by personal breathing zone air sampling. J Expo Anal Environ Epidemiol. 1996;6:473-502 pubmed
    ..5 microns diameter), ultraviolet absorbing particulate matter, fluorescing particulate matter, solanesol, scopoletin, nicotine, 3-ethenyl pyridine, and myosmine...
  40. Oliveira E, Romero M, Silva M, Silva B, Medeiros I. Intracellular calcium mobilization as a target for the spasmolytic action of scopoletin. Planta Med. 2001;67:605-8 pubmed
    The coumarin scopoletin was isolated in a pure form from the roots of Brunfelsia hopeana Benth. (Solanaceae)...
  41. El Hady S, Bukuru J, Kesteleyn B, Van Puyvelde L, Van T, De Kimpe N. New pyranonaphthoquinone and pyranonaphthohydroquinone from the roots of Pentas longiflora. J Nat Prod. 2002;65:1377-9 pubmed
    ..the dichloromethane extract were isolated the three known compounds 3-methoxymollugin, methyl-3-prenyl-1,4-naphthoquinone-2-carboxylate, and scopoletin, while the ethyl acetate extract afforded the known 2-methoxy-3-methylanthraquinone.
  42. Yang Z, Zhang Y, Ding W, Luo J. [Lethal effects of scopoletin and bisdemethoxycurcumin against Tetranychus cinnabarinus Boisd. (Acari: Tetranychidae): a simulation study]. Ying Yong Sheng Tai Xue Bao. 2013;24:197-204 pubmed
    By using slide-dip bioassay method under laboratory condition, an investigation was made on the lethal effects of scopoletin, bisdemethoxycurcumin (BDMC), and their combination at an optimal mass ratio (7:6) of scopoletin to BDMC against ..
  43. Gnonlonfin B, Gbaguidi F, Gbenou J, Sanni A, Brimer L. Changes in scopoletin concentration in cassava chips from four varieties during storage. J Sci Food Agric. 2011;91:2344-7 pubmed publisher
    ..examination earlier revealed the accumulation of the four hydroxycoumarins esculetin, esculin, scopolin and scopoletin derived from the phenylpropanoid pathway, during the time course of postharvest deterioration...
  44. Siddiqui B, Sattar F, Ahmad F, Begum S. Isolation and structural elucidation of chemical constituents from the fruits of Morinda citrifolia Linn. Arch Pharm Res. 2007;30:919-23 pubmed
    ..afforded a new constituent, morinaphthalenone (1), and three known constituents, scopoletin (2), 1, 3-dimethoxy-anthraquinone (3) and 1, 2-dihydroxy-anthraquinone (4)...
  45. Xia Y, Dai Y, Meng Q, Wang Q, Qiu L. [Studies on absorption kinetics of scopoletin in rat stomachs and intestines]. Zhongguo Zhong Yao Za Zhi. 2008;33:1890-4 pubmed
    To study absorption kinetics of scopoletin in rat stomachs and intestines. Rats was cannulated for in situ recirculation. UV and HPLC methods were used to determine the concentrations of phenolsulfonphthalein and scopoletin, respectively...
  46. Pan R, Gao X, Lu D, Xu X, Xia Y, Dai Y. Prevention of FGF-2-induced angiogenesis by scopoletin, a coumarin compound isolated from Erycibe obtusifolia Benth, and its mechanism of action. Int Immunopharmacol. 2011;11:2007-16 pubmed publisher
    Previous work in our laboratory has shown that scopoletin, one of the main bioactive constituents of Erycibe obtusifolia Benth stems, exerts anti-arthritic activity in vivo partly by preventing synovial angiogenesis...
  47. Chaerle L, Lenk S, Hagenbeek D, Buschmann C, Van Der Straeten D. Multicolor fluorescence imaging for early detection of the hypersensitive reaction to tobacco mosaic virus. J Plant Physiol. 2007;164:253-62 pubmed
    ..The multichannel imaging system permitted to discern the key components salicylic acid and scopoletin. In contrast, for the compatible interaction between TMV and non-resistant tobacco, no presymptomatic responses ..
  48. Geng C, Wang W, Lin M, Ye J. Determination of active ingredients in mutouhui by capillary electrophoresis with electrochemical detection. J Capill Electrophor Microchip Technol. 2007;10:63-7 pubmed
    ..zone electrophoresis with electrochemical detection has been used for the separation and determination of scopoletin, hyperin, chlorogenic acid, and quercetin in Mutouhui...
  49. Jeandet P, Clement C, Courot E, Cordelier S. Modulation of phytoalexin biosynthesis in engineered plants for disease resistance. Int J Mol Sci. 2013;14:14136-70 pubmed publisher
  50. Khan S, Riaz N, Afza N, Malik A, Aziz Ur Rehman -, Iqbal L, et al. Antioxidant constituents from Cotoneaster racemiflora. J Asian Nat Prod Res. 2009;11:44-8 pubmed publisher
    ..racemiside (1), has been isolated from the ethyl acetate-soluble fraction of Cotoneaster racemiflora, along with scopoletin (2), 7,8-dimethoxy-6-hydroxycoumarin (3), 3,3',4'-tri-O-methylellagic acid (4), and cereotagloperoxide (5), ..
  51. El Oirdi M, Trapani A, Bouarab K. The nature of tobacco resistance against Botrytis cinerea depends on the infection structures of the pathogen. Environ Microbiol. 2010;12:239-53 pubmed publisher
    ..samsun is resistant to B. cinerea. This resistance is correlated with the accumulation of the phytoalexin scopoletin and PR proteins. We also show that this resistance depends on the type of B. cinerea stage. Nicotiana tabacum cv...
  52. Naressi M, Ribeiro M, Bersani Amado C, Zamuner M, Costa W, Tanaka C, et al. Chemical composition, anti-inflammatory, molluscicidal and free-radical scavenging activities of the leaves of Ficus radicans 'Variegata' (Moraceae). Nat Prod Res. 2012;26:323-30 pubmed publisher
    ..The compounds were identified on the basis of their NMR spectral data and comparison with those previously reported in the literature. ..
  53. Baillieul F, De Ruffray P, Kauffmann S. Molecular cloning and biological activity of alpha-, beta-, and gamma-megaspermin, three elicitins secreted by Phytophthora megasperma H20. Plant Physiol. 2003;131:155-66 pubmed
    ..by measuring the levels of acidic and basic pathogenesis-related proteins and of the antioxidant phytoalexin scopoletin. The three elicitins induced similar levels of systemic acquired resistance measured as the expression of acidic ..