pimozide

Summary

Summary: A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to HALOPERIDOL for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403)

Top Publications

  1. Bruggeman R, van der Linden C, Buitelaar J, Gericke G, Hawkridge S, Temlett J. Risperidone versus pimozide in Tourette's disorder: a comparative double-blind parallel-group study. J Clin Psychiatry. 2001;62:50-6 pubmed
    ..potential in Tourette's disorder, we studied the safety and efficacy of risperidone in comparison with pimozide in patients with Tourette's disorder diagnosed according to DSM-III-R...
  2. Drolet B, Rousseau G, Daleau P, Cardinal R, Simard C, Turgeon J. Pimozide (Orap) prolongs cardiac repolarization by blocking the rapid component of the delayed rectifier potassium current in native cardiac myocytes. J Cardiovasc Pharmacol Ther. 2001;6:255-60 pubmed
    Several cases of QT prolongation and ventricular tachyarrhythmia have been reported with pimozide, a potent neuroleptic useful in the management of motor and phonic tics associated with Tourette syndrome...
  3. Rogers H, Bhattaram A, Zineh I, Gobburu J, Mathis M, Laughren T, et al. CYP2D6 genotype information to guide pimozide treatment in adult and pediatric patients: basis for the U.S. Food and Drug Administration's new dosing recommendations. J Clin Psychiatry. 2012;73:1187-90 pubmed publisher
    The occurrence of pimozide-induced arrhythmias is concentration dependent. Hence, it is important for prescribers to consider causes of increased pimozide exposure. This article summarizes the U.S...
  4. Johnston L, Beninger R, Olmstead M. Pimozide, like extinction, devalues stimuli associated with sucrose taking. Pharmacol Biochem Behav. 2001;68:583-90 pubmed
    ..Sucrose-taking responses were either extinguished or reinforced under the influence of the DA antagonist, pimozide. Control groups were also reinforced for sucrose-taking responses but received no injection or a vehicle ..
  5. Silva M, Bernardi M, Cruz Casallas P, Felicio L. Pimozide injections into the Nucleus accumbens disrupt maternal behaviour in lactating rats. Pharmacol Toxicol. 2003;93:42-7 pubmed
    ..It has been previously demonstrated that peripheral injections of some antipsychotic drugs such as pimozide have disruptive effects on maternal behaviour...
  6. Gilbert D, Batterson J, Sethuraman G, Sallee F. Tic reduction with risperidone versus pimozide in a randomized, double-blind, crossover trial. J Am Acad Child Adolesc Psychiatry. 2004;43:206-14 pubmed
    To compare the tic suppression, electrocardiogram (ECG) changes, weight gain, and side effect profiles of pimozide versus risperidone in children and adolescents with tic disorders...
  7. Ishiwari K, Betz A, Weber S, Felsted J, Salamone J. Validation of the tremulous jaw movement model for assessment of the motor effects of typical and atypical antipychotics: effects of pimozide (Orap) in rats. Pharmacol Biochem Behav. 2005;80:351-62 pubmed
    ..validate this model with additional drugs, the present studies assessed the effects of the typical antipsychotic pimozide. In the first series of experiments, the effects of acute pimozide on tacrine-induced TJMs and lever pressing ..
  8. Shull J, Gorski J. Regulation of prolactin gene transcription in vivo: interactions between estrogen, pimozide, and alpha-ergocryptine. Mol Pharmacol. 1990;37:215-21 pubmed
    A single injection of pimozide, a dopamine antagonist, rapidly stimulated prolactin (PRL) gene transcription in male rats, whereas an injection of alpha-ergocryptine, a dopamine agonist, rapidly inhibited PRL gene transcription...
  9. Nelson E, Walker S, Weisberg E, Bar Natan M, Barrett R, Gashin L, et al. The STAT5 inhibitor pimozide decreases survival of chronic myelogenous leukemia cells resistant to kinase inhibitors. Blood. 2011;117:3421-9 pubmed publisher
    ..Using this approach, we identified the psychotropic drug pimozide as a STAT5 inhibitor...

More Information

Publications97

  1. Betz A, Vontell R, Valenta J, Worden L, Sink K, Font L, et al. Effects of the adenosine A 2A antagonist KW 6002 (istradefylline) on pimozide-induced oral tremor and striatal c-Fos expression: comparisons with the muscarinic antagonist tropicamide. Neuroscience. 2009;163:97-108 pubmed publisher
    Typical antipsychotic drugs, including haloperidol and pimozide, have been shown to produce parkinsonian motor effects such as akinesia and tremor...
  2. Zhang Z, Lee Y, Rhodes K, Wang K, Argentieri T, Wang Q. Inhibitory effects of pimozide on cloned and native voltage-gated potassium channels. Brain Res Mol Brain Res. 2003;115:29-38 pubmed
    The primary goal of this study was to use the cloned neuronal Kv channels to test if pimozide (PMZD), an antipsychotic drug, modulates the activity of Kv channels. In CHO cells, PMZD blocked Kv2...
  3. Bertolesi G, Shi C, Elbaum L, Jollimore C, Rozenberg G, Barnes S, et al. The Ca(2+) channel antagonists mibefradil and pimozide inhibit cell growth via different cytotoxic mechanisms. Mol Pharmacol. 2002;62:210-9 pubmed
    ..expressing T-type Ca(2+) channels (T-channels) are more sensitive to the antiproliferative effects of the drugs pimozide and mibefradil than cells without significant T-channel expression...
  4. Grabski R, Dewit J, De Braekeleer J, Malicka Blaskiewicz M, De Baetselier P, Verschueren H. Inhibition of T-cell invasion across cultured fibroblast monolayers by phenothiazine-related calmodulin inhibitors: impairment of lymphocyte motility by trifluoperazine and chlorpromazine, and alteration of the monolayer by pimozide. Biochem Pharmacol. 2001;61:1313-7 pubmed
    ..the effect of trifluoperazine and chlorpromazine (TFP and CP, two strong inhibitors of lymphocyte motility) and pimozide (PIM, a much weaker inhibitor of lymphocyte motility but a strong inhibitor of calmodulin) on invasion of human ..
  5. Phillips K. Placebo-controlled study of pimozide augmentation of fluoxetine in body dysmorphic disorder. Am J Psychiatry. 2005;162:377-9 pubmed
    ..or its delusional variant participated in an 8-week, placebo-controlled, double-blind, parallel-group study of pimozide augmentation of fluoxetine. Pimozide was not more effective than placebo: two (18...
  6. Brauer L, de Wit H. High dose pimozide does not block amphetamine-induced euphoria in normal volunteers. Pharmacol Biochem Behav. 1997;56:265-72 pubmed
    ..study was to evaluate the effects of a relatively high acute dose (8 mg) of the dopamine receptor antagonist, pimozide, on responses to d-amphetamine (10 and 20 mg) in normal volunteers...
  7. Lieberman L, Higgins D. A small-molecule screen identifies the antipsychotic drug pimozide as an inhibitor of Listeria monocytogenes infection. Antimicrob Agents Chemother. 2009;53:756-64 pubmed publisher
    ..b>Pimozide, an FDA-approved drug used to treat severe Tourette's syndrome and schizophrenia, was further examined and shown ..
  8. Bancila M, Copin J, Daali Y, Schatlo B, Gasche Y, Bijlenga P. Two structurally different T-type Ca 2+ channel inhibitors, mibefradil and pimozide, protect CA1 neurons from delayed death after global ischemia in rats. Fundam Clin Pharmacol. 2011;25:469-78 pubmed publisher
    ..The aim of this work was to study the neuroprotective potential of mibefradil and pimozide, both T-type Ca(2+) channel inhibitors, in an in vivo rat model of global ischemia...
  9. Gulisano M, Calì P, Cavanna A, Eddy C, Rickards H, Rizzo R. Cardiovascular safety of aripiprazole and pimozide in young patients with Tourette syndrome. Neurol Sci. 2011;32:1213-7 pubmed publisher
    ..assessed the cardiovascular safety of the newer antipsychotic aripiprazole in comparison with the neuroleptic pimozide among young patients affected by TS...
  10. Zhang L, Yu J, Pan H, Hu P, Hao Y, Cai W, et al. Small molecule regulators of autophagy identified by an image-based high-throughput screen. Proc Natl Acad Sci U S A. 2007;104:19023-8 pubmed
    ..Our studies suggest the possibility that some of these drugs may be useful for the treatment of Huntington's and other human diseases associated with the accumulation of misfolded proteins. ..
  11. Onofrj M, Paci C, D Andreamatteo G, Toma L. Olanzapine in severe Gilles de la Tourette syndrome: a 52-week double-blind cross-over study vs. low-dose pimozide. J Neurol. 2000;247:443-6 pubmed
    ..low-dose pimozide (2 and 4 mg daily)...
  12. van Vloten W. Pimozide: use in dermatology. Dermatol Online J. 2003;9:3 pubmed
    b>Pimozide is widely used in psychiatry for chronic psychoses, schizophrenia, the syndrome of Gilles de la Tourette and to a certain extent, also in dermatology. The only dermatological indication is for delusions of parasitosis...
  13. Kang J, Chen X, Rampe D. The antipsychotic drugs sertindole and pimozide block erg3, a human brain K(+) channel. Biochem Biophys Res Commun. 2001;286:499-504 pubmed
    The antipsychotic drugs sertindole and pimozide are known to prolong the QT interval on the electrocardiogram via a high affinity block of the cardiac K(+) channel known as HERG (human ether-a-go-go-related gene; erg1)...
  14. Rumondor A, Taylor L. Effect of polymer hygroscopicity on the phase behavior of amorphous solid dispersions in the presence of moisture. Mol Pharm. 2010;7:477-90 pubmed publisher
    ..acetate) (PVPVA), and hypromellose acetate succinate (HPMCAS) were selected as model polymers, and felodipine, pimozide, indomethacin, and quinidine were selected as model drugs...
  15. Thang L, Breadmore M, See H. Electrokinetic supercharging in nonaqueous capillary electrophoresis for online preconcentration and determination of tamoxifen and its metabolites in human plasma. J Chromatogr A. 2016;1461:185-91 pubmed publisher
    ..The sample was injected at 10kV for 300s, followed by HI of 10mM pimozide as TE at 150mbar for 36s (4% of total capillary volume). Separation was performed in 7...
  16. Mapes J, Anandan L, Li Q, Neff A, Clevenger C, Bagchi I, et al. Aberrantly high expression of the CUB and zona pellucida-like domain-containing protein 1 (CUZD1) in mammary epithelium leads to breast tumorigenesis. J Biol Chem. 2018;293:2850-2864 pubmed publisher
    ..Selective blockade of STAT5 phosphorylation by pimozide, a small-molecule inhibitor, markedly reduced the production of the EGF family growth factors and inhibited PRL-..
  17. Patten S, Aggad D, Martinez J, Tremblay E, Petrillo J, Armstrong G, et al. Neuroleptics as therapeutic compounds stabilizing neuromuscular transmission in amyotrophic lateral sclerosis. JCI Insight. 2017;2: pubmed publisher
    ..elegans and in zebrafish, and the most potent was pimozide, which blocked T-type Ca2+ channels in these simple models and stabilized neuromuscular transmission in zebrafish ..
  18. Chen J, Dexheimer T, Ai Y, Liang Q, Villamil M, Inglese J, et al. Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells. Chem Biol. 2011;18:1390-400 pubmed publisher
    ..The top inhibitors, pimozide and GW7647, inhibited USP1/UAF1 noncompetitively with a K(i) of 0.5 and 0...
  19. Gonçalves J, Cordeiro M, Rivero E. The Role of the Complex USP1/WDR48 in Differentiation and Proliferation Processes in Cancer Stem Cells. Curr Stem Cell Res Ther. 2017;12:416-422 pubmed publisher
    ..For this reason, inhibitors as Pimozide, GW7647, C527, SJB2-043, ML323 have been studied to inhibit USPs in cases of treatment intervention...
  20. Forcada F, Zúñiga O, Abecia J. The role of nutrition in the regulation of LH secretion during anestrus by the serotoninergic and dopaminergic systems in Mediterranean ewes treated with melatonin. Theriogenology. 2002;58:1303-13 pubmed
    ..SHT2) receptor antagonist, was administered in early and late anestrus (Day 50 and 107) followed by pimozide (0.08 mg/kg), a dopaminergic2 receptor antagonist (Day 57 and 114)...
  21. Shiotani M, Harada T, Abe J, Sawada Y, Hashimoto K, Hamada Y, et al. Practical application of guinea pig telemetry system for QT evaluation. J Toxicol Sci. 2005;30:239-47 pubmed
    ..on human QT interval are well established: 8 positive references (bepridil, terfenadine, cisapride, haloperidol, pimozide, quinidine, E-4031 and thioridazine), and 2 negative references (propranolol and nifedipine)...
  22. Grosso S, Verrotti A, Messina M, Sacchini M, Balestri P. Management of status dystonicus in children. Cases report and review. Eur J Paediatr Neurol. 2012;16:390-5 pubmed publisher
    ..All our patients underwent continuous infusion of midazolam, in association with pimozide and trihexyphenidyl, which led to complete resolution of muscular spasms in two patients...
  23. Marchant T, Chang J, Nahorniak C, Peter R. Evidence that gonadotropin-releasing hormone also functions as a growth hormone-releasing factor in the goldfish. Endocrinology. 1989;124:2509-18 pubmed
    ..Furthermore, the dopamine antagonist pimozide did not influence serum GH levels, although pimozide potentiated the stimulatory effect of GnRH on GTH secretion ..
  24. Kenchaiah B, Kumar S, Tharyan P. Atypical anti-psychotics in delusional parasitosis: a retrospective case series of 20 patients. Int J Dermatol. 2010;49:95-100 pubmed publisher
    ..b>Pimozide has been mooted as specific for the treatment of this condition...
  25. Veale D, Chapman H. Classification approach. Br Dent J. 2005;198:2; author reply 2-3 pubmed
  26. Feng M, Navar L. Angiotensin II-mediated constriction of afferent and efferent arterioles involves T-type Ca2+ channel activation. Am J Nephrol. 2004;24:641-8 pubmed
    ..Single AA or EA were visualized and superfused with solutions containing Ang II alone or with a TCC blocker, pimozide, or a LCC blocker, diltiazem. Pimozide at 10 micromol/l significantly dilated EA (19.7 +/- 1...
  27. Covell D. Integrating constitutive gene expression and chemoactivity: mining the NCI60 anticancer screen. PLoS ONE. 2012;7:e44631 pubmed publisher
    ..The data used in this analysis is available at http://pubchem.ncbi.nlm.nih.gov/andhttp://www.ncbi.nlm.nih.gov/projects/geo (GPL96, GSE32474). ..
  28. Yang Y, Hu S, Liu J, Cui Y, Fan Y, Lv T, et al. CD8+ T cells promote proliferation of benign prostatic hyperplasia epithelial cells under low androgen level via modulation of CCL5/STAT5/CCND1 signaling pathway. Sci Rep. 2017;7:42893 pubmed publisher
    ..Suppressed CCL5/STAT5 signals via CCL5 neutralizing antibody or STAT5 inhibitor Pimozide led to reverse CD8+ T cell-enhanced BECs proliferation...
  29. Tatsumi M, Jansen K, Blakely R, Richelson E. Pharmacological profile of neuroleptics at human monoamine transporters. Eur J Pharmacol. 1999;368:277-83 pubmed
    ..At the human dopamine transporter, only pimozide (K(D) = 69+/-3) ziprasidone (K(D) = 76+/-5) had notable potency...
  30. Sokolowska Mikolajczyk M, Socha M, Mikolajczyk T, Chyb J, Epler P. Seasonal short-term effects of naltrexone on LH secretion in male carp (Cyprinus carpio L.). Comp Biochem Physiol C Toxicol Pharmacol. 2002;131:379-85 pubmed
    ..Moreover, the possible involvement of the dopaminergic system was studied in fish pre-treated with pimozide (dopamine receptor antagonist) and in intact fish...
  31. Younis I, Rogers H, Zhang H, Zhu H, Uppoor R, Mehta M. An integrated clinical pharmacology approach for deriving dosing recommendations in a regulatory setting: review of recent cases in psychiatry drugs. J Clin Pharmacol. 2013;53:1005-9 pubmed publisher
    ..This in turn expands the benefits of any given drug to all individuals in which the drug is likely to be effective. ..
  32. Martin W, Forouzanfar T. The efficacy of anticonvulsants on orofacial pain: a systematic review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011;111:627-33 pubmed publisher
    ..Controversy exists about the effectiveness of anticonvulsants for the management of orofacial pain disorders. To ascertain appropriate therapies, a systematic review was conducted of existing randomized controlled trials...
  33. Bryon M, Jaffe A. Disabling cough: habit disorder or tic syndrome?. Lancet. 2003;361:1991-2; author reply 1992 pubmed
  34. Stoker T, Robinette C, Britt B, Laws S, Cooper R. Prepubertal exposure to compounds that increase prolactin secretion in the male rat: effects on the adult prostate. Biol Reprod. 1999;61:1636-43 pubmed
    ..These compounds included pimozide (a dopamine antagonist), estradiol-17beta, and bisphenol A (a monomer of polycarbonate plastics reported to have ..
  35. Bhatia M, Chandra R, Kamra A. Delusional parasitosis in leprosy. Indian J Lepr. 2002;74:159-60 pubmed
  36. Yang C, Huang H, Zhang L, Zhu C, Guo Q. Aripiprazole for the treatment of tic disorders in children: a systematic review and meta-analysis. BMC Psychiatry. 2015;15:179 pubmed publisher
    ..Typical antipsychotics, such as haloperidol and pimozide have been prescribed to control tic symptoms as first-line agents...
  37. Dalsgaard S, Damm D, Thomsen P. Gilles de la Tourette syndrome in a child with congenital deafness. Eur Child Adolesc Psychiatry. 2001;10:256-9 pubmed
    ..The case presented here supports previously published work that the intentional share of the tics in GTS is very small. This case also questions former theories on which regions and circuits of the brain are involved in GTS. ..
  38. Roth J. The colorful spectrum of Tourette syndrome and its medical, surgical and behavioral therapies. Parkinsonism Relat Disord. 2018;46 Suppl 1:S75-S79 pubmed publisher
    ..g. haloperidol, pimozide, fluphenazine), benzodiazepines (clonazepam) and tetrabenazine are employed less frequently...
  39. Gunduz Bruce H, Oliver S, Gueorguieva R, Forselius Bielen K, D Souza D, Zimolo Z, et al. Efficacy of pimozide augmentation for clozapine partial responders with schizophrenia. Schizophr Res. 2013;143:344-7 pubmed publisher
    ..in patients with schizophrenia currently receiving clozapine with partial response, and tested the efficacy of pimozide augmentation on positive and negative symptoms and also on neurocognitive measures...
  40. Ni Y, Li K, Xu W, Song L, Yao K, Zhang X, et al. Acrosome reaction induced by recombinant human zona pellucida 3 peptides rhuZP3a22 approximately 176 and rhuZP3b177 approximately 348 and their mechanism. J Androl. 2007;28:381-8 pubmed
    ..The AR could be inhibited by pertussis toxin (PTX), EGTA, and pimozide (a T-type calcium channel blocker), whereas verapamil was less effective in this regard...
  41. Kelly B. Erotomania : epidemiology and management. CNS Drugs. 2005;19:657-69 pubmed
    ..In the past, the antipsychotic medication pimozide was commonly used, at least in certain countries (such as the US and Canada), despite a paucity of systematic ..
  42. Chen B, Hsiao S. Anticipatory contrast effect in rats: a new view with lick response analysis and the effect of dopamine blocking. Chin J Physiol. 1996;39:235-43 pubmed
    ..On days 13 to 16, and 12 and 17, pimozide (0.4 mg/kg, i.p.), and the vehicle solution were injected, respectively...
  43. Decombe R, Rivot J, Aunis D, Abrous N, Peschanski M, Herman J. Importance of catecholamine release for the functional action of intrastriatal implants of adrenal medullary cells: pharmacological analysis and in vivo electrochemistry. Exp Neurol. 1990;107:143-53 pubmed
    ..5 mg/kg, 10 min) or the dopamine receptor blocker pimozide (0.5 mg/kg, 1 h), although the latter pretreatment blocked the amphetamine-evoked rotation...
  44. Karlas A, Berrè S, Couderc T, Varjak M, Braun P, Meyer M, et al. A human genome-wide loss-of-function screen identifies effective chikungunya antiviral drugs. Nat Commun. 2016;7:11320 pubmed publisher
    ..Two of them, the calmodulin inhibitor pimozide and the fatty acid synthesis inhibitor TOFA, have a therapeutic effect in vivo when combined...
  45. Cokelaere M, Kuhn E. Influence of pimozide on a TRH induced TSH secretion in the rat during food deprivation. Horm Metab Res. 1992;24:53-5 pubmed
    ..obtained following a prolonged (injections during 3 consecutive days) or acute treatment (single injection) with pimozide (1 mg/injection)...
  46. Wilson F, Uslan D. Delusional parasitosis. Mayo Clin Proc. 2004;79:1470 pubmed
  47. Tatlipinar S, Iener E, Ilhan B, Semerci B. Ophthalmic manifestations of Gilles de la Tourette syndrome. Eur J Ophthalmol. 2001;11:223-6 pubmed
    ..The symptoms improved considerably in 82% of the patients with eye tics on treatment with a neuroleptic (pimozide). Blepharospasm was the most common ophthalmic manifestation of GTS...
  48. Freudenmann R. [Delusions of parasitosis: An up-to-date review]. Fortschr Neurol Psychiatr. 2002;70:531-41 pubmed
    ..The available information on the therapeutic gold standard, the neuroleptic agent pimozide, is discussed...
  49. Kemp P, Kim K, Borok Z, Crandall E. Re-evaluating the Na(+) conductance of adult rat alveolar type II pneumocytes: evidence for the involvement of cGMP-activated cation channels. J Physiol. 2001;536:693-701 pubmed
    ..in contrast, Ni(2+) was a very weak inhibitor (30 % inhibition at 10 mM). 4. Pimozide (10 microM) caused inhibition of whole-cell cation conductance by approximately 55 %...
  50. Rondanin R, Simoni D, Maccesi M, Romagnoli R, Grimaudo S, Pipitone R, et al. Effects of Pimozide Derivatives on pSTAT5 in K562 Cells. ChemMedChem. 2017;12:1183-1190 pubmed publisher
    ..The neuroleptic drug pimozide was recently reported to act as an inhibitor of STAT5 phosphorylation and is capable of inducing apoptosis in CML ..
  51. Fernando N. Monosymptomatic hypochondriasis treated with a tricyclic antidepressant. Br J Psychiatry. 1988;152:851-2 pubmed
    A case of a patient with monosymptomatic hypochondriasis exhibiting koro-like symptoms is reported. The patient did not respond to pimozide, but improved with a tricyclic antidepressant and has remained symptom-free for 1.5 years.
  52. Maeda K, Yamamoto Y, Yasuda M, Ishii K. Delusions of oral parasitosis. Prog Neuropsychopharmacol Biol Psychiatry. 1998;22:243-8 pubmed
    ..3. The authors examined the effect of pimozide, whose efficacy on delusional skin parasitosis has been proven...
  53. Starkova L, Wiedermann J. Our experience with incisive neuroleptic drugs in child psychiatry. Acta Univ Palacki Olomuc Fac Med. 1991;131:213-7 pubmed
    ..report their own experiences of treatment with incisive neuroleptic drugs in child psychiatry (haloperidol, pimozide, penfluridol, sulpiride)...
  54. Zarrindast M, Jamali Raeufy N, Shafaghi B. Effects of high doses of theophylline on memory acquisition. Psychopharmacology (Berl). 1995;122:307-11 pubmed
    ..b>Pimozide and the beta-adrenoreceptor propranolol also decreased the drug response...
  55. Phillips K, Hollander E. Treating body dysmorphic disorder with medication: evidence, misconceptions, and a suggested approach. Body Image. 2008;5:13-27 pubmed publisher
    ..Finally, some misconceptions about pharmacotherapy, gaps in knowledge about BDD's treatment, and the need for additional research are discussed. ..
  56. Lee C. Delusions of parasitosis. Dermatol Ther. 2008;21:2-7 pubmed publisher
    ..The traditional treatment of choice for delusions of parasitosis is the antipsychotic medication pimozide (Orap, Gate Pharmaceuticals, Philadelphia, PA)...
  57. Karaaslan F, Gonul A, Oguz A, Erdinc E, Esel E. P300 changes in major depressive disorders with and without psychotic features. J Affect Disord. 2003;73:283-7 pubmed
  58. Bonaccorsi L, Forti G, Baldi E. Low-voltage-activated calcium channels are not involved in capacitation and biological response to progesterone in human sperm. Int J Androl. 2001;24:341-51 pubmed
    ..and capacitation, by employing three different pharmacological antagonists of VOCCT, namely mibefradil (Ro 5967), pimozide and amiloride...
  59. Ohyama T, Horvitz J, Kitsos E, Balsam P. The role of dopamine in the timing of Pavlovian conditioned keypecking in ring doves. Pharmacol Biochem Behav. 2001;69:617-27 pubmed
    ..Experiment 1 demonstrated that injections of pimozide before each session immediately decreased response rates but shifted timing distributions gradually to the right ..
  60. Johnstone E, Owens D, Crow T, Davis J. Does a four-week delay in the introduction of medication alter the course of functional psychosis?. J Psychopharmacol. 1999;13:238-44 pubmed
    ..of 105 patients with functional psychotic illness who had participated in a random and blind 4-week trial of pimozide, lithium, both and placebo...
  61. Agarwal M, Giannoni Guzmán M, Morales Matos C, Del Valle Díaz R, Abramson C, Giray T. Dopamine and octopamine influence avoidance learning of honey bees in a place preference assay. PLoS ONE. 2011;6:e25371 pubmed publisher
    ..The effects during acquisition are specific as shown in experiments using the antagonists Pimozide and Mianserin for DA and OA receptors, respectively...
  62. Stager S, Calis K, Grothe D, Bloch M, Berensen N, Smith P, et al. Treatment with medications affecting dopaminergic and serotonergic mechanisms: effects on fluency and anxiety in persons who stutter. J Fluency Disord. 2005;30:319-35 pubmed
    ..affect fluency, a selective serotonin reuptake inhibitor, paroxetine, and a selective dopamine (D-2) antagonist, pimozide, were evaluated...
  63. Koo J, Lee C. Delusions of parasitosis. A dermatologist's guide to diagnosis and treatment. Am J Clin Dermatol. 2001;2:285-90 pubmed
    ..The current treatment of choice is the antipsychotic medication pimozide. The principal difficulty in management is convincing patients to take the drug...
  64. Friedman J, Lindenmayer J, Alcantara F, Bowler S, Parak M, White L, et al. Pimozide augmentation of clozapine inpatients with schizophrenia and schizoaffective disorder unresponsive to clozapine monotherapy. Neuropsychopharmacology. 2011;36:1289-95 pubmed publisher
    ..b>Pimozide, a diphenylbutylpiperidine, possesses pharmacological and clinical properties distinct from other typical ..
  65. Nejad A, Toofani K. Delusion of oral parasitosis in a patient with major depressive disorder. Can J Psychiatry. 2005;50:301-2 pubmed
  66. Sharaf S. Effect of GnRHa, pimozide and Ovaprim on ovulation and plasma sex steroid hormones in African catfish Clarias gariepinus. Theriogenology. 2012;77:1709-16 pubmed publisher
    ..9% NaCl) as a control group, 0.5 ml kg(-1) Ovaprim, 20 and 40 ?g kg(-1) BW of GnRHa, 8 and 16 mL kg(-1) pimozide tablets and the following combination of GnRHa with pimozide (GP): 20 ?g + 4 mg, 30 ?g + 8 mg and 40 ?g + 16 mg ..
  67. Kågström J, Sjögren E, Ericson A. Evaluation of the guinea pig monophasic action potential (MAP) assay in predicting drug-induced delay of ventricular repolarisation using 12 clinically documented drugs. J Pharmacol Toxicol Methods. 2007;56:186-93 pubmed
    ..Overall, the study reinforces the anaesthetised guinea pig MAP model as a reliable assay predicting QT liability of new chemical entities and as a highly sensitive early screening model for cardiovascular risk. ..
  68. Tani E, Rekka E, Kourounakis P. Modification of lipid peroxidation by some known substituted imidazole derivatives. An attempt to correlate their antioxidant activity with lipophilicity. Pharmazie. 1991;46:118-9 pubmed
    The antioxidant activity of two antiallergic agents, oxatomide, astemizole and two neuroleptic drugs, penfluridol, pimozide, structurally related, was tested, using heat-inactivated rat hepatic microsomal fraction and linoleic acid...
  69. Mothi M, Sampson S. Pimozide for schizophrenia or related psychoses. Cochrane Database Syst Rev. 2013;:CD001949 pubmed publisher
    b>Pimozide, formulated in the 1960s, continues to be marketed for the care of people with schizophrenia or related psychoses such as delusional disorder. It has been associated with cardiotoxicity and sudden unexplained death...
  70. Samarghandian S, Ohata H, Yamauchi N, Shibasaki T. Corticotropin-releasing factor as well as opioid and dopamine are involved in tail-pinch-induced food intake of rats. Neuroscience. 2003;116:519-24 pubmed
    ..Tail-pinch- or CRF-induced food intake was blocked by naloxone, pimozide, and spiperone...
  71. Isoya E, Toyoda F, Imai S, Okumura N, Kumagai K, Omatsu Kanbe M, et al. Swelling-activated Cl(-) current in isolated rabbit articular chondrocytes: inhibition by arachidonic Acid. J Pharmacol Sci. 2009;109:293-304 pubmed
    ..blockers 5-nitro-2-(3-phenylpropylamino)benzoic acid, glibenclamide, and tamoxifen, but was little affected by pimozide. I(Cl,swell) was also found to be acutely inhibited by arachidonic acid in a concentration-dependent manner with ..
  72. Xia M, Salata J, Figueroa D, Lawlor A, Liang H, Liu Y, et al. Functional expression of L- and T-type Ca2+ channels in murine HL-1 cells. J Mol Cell Cardiol. 2004;36:111-9 pubmed
    ..L-type (nimodipine and verapamil) and T-type (mibefradil and pimozide) Ca2+ channel blockers inhibited Ca2+ influx with IC50s of 1, 2, 0.4 and 0.2 microM, respectively...
  73. Marks C, Lindeberg H, Van Cleeff J. Bait-delivered pimozide causes precocious embryo implantation in mink: a fertility control option for the exotic stoat?. Reprod Fertil Dev. 2006;18:703-8 pubmed
    ..A bait dose of 0.8 mg kg(-1) of pimozide was more effective in elevating PRL levels than equivalent doses of fluphenazine, sulpiride (P < 0...
  74. Hsiao S, Chen B. Complex response competition and dopamine blocking: choosing of high cost sucrose solution versus low cost water in rats. Chin J Physiol. 1995;38:99-109 pubmed
    The effect of DA blocking with pimozide on complex response competition involving coupling of cost and benefit was studied with a double-bottle test in lickometer: The competition occurred between two responses; licking of 2% sucrose ..
  75. Wiley J, Compton A, Golden K. Separation of drug effects on timing and behavioral inhibition by increased stimulus control. Exp Clin Psychopharmacol. 2000;8:451-61 pubmed
    ..In contrast, pimozide and desipramine increased long-delay responses across both components, resulting in longer mean interresponse ..
  76. Santi C, Cayabyab F, Sutton K, McRory J, Mezeyova J, Hamming K, et al. Differential inhibition of T-type calcium channels by neuroleptics. J Neurosci. 2002;22:396-403 pubmed
    ..Among the neuroleptics tested, the diphenylbutylpiperidines pimozide and penfluridol were the most potent T-type channel blockers with Kd values (approximately 30-50 nm and ..
  77. Kessler A. Effects of medications on regulation of body temperature of patients with Tourette syndrome. J Child Neurol. 2004;19:220-4 pubmed
    ..Correlating the neurologic status to hypothalamic dysregulation, the data presented in this study strengthen the hypothesis of an idiopathic hypothalamic disorder underlying the Tourette syndrome cascade. ..
  78. King S, Caldarone B, Picciotto M. Beta2-subunit-containing nicotinic acetylcholine receptors are critical for dopamine-dependent locomotor activation following repeated nicotine administration. Neuropharmacology. 2004;47 Suppl 1:132-9 pubmed
    ..in response to chronic nicotine which was blocked by oral administration of the dopamine receptor antagonist pimozide. Knockout mice lacking the beta2 subunit of the nAChR did not show locomotor activation in response to chronic ..
  79. Sousa F, Gomes P, Noronha E, Macedo D, Vasconcelos S, Fonteles M, et al. Effects of dopaminergic and cholinergic interactions on rat behavior. Life Sci. 2001;69:2419-28 pubmed
    ..Results showed that carbachol at the highest dose used (10 mg/kg, p.o.) decreased and pimozide at the dose used abolished locomotor activity. Atropine at a low dose (1 mg/kg, p.o...
  80. Chiang A, Bass A, Cooper M, Engwall M, Menton R, Thomas K. ILSI-HESI cardiovascular safety subcommittee dataset: an analysis of the statistical properties of QT interval and rate-corrected QT interval (QTc). J Pharmacol Toxicol Methods. 2007;56:95-102 pubmed
    ..significant treatment-related effects, while the analyses for QTcQ identified all positive compounds except pimozide. The power analysis shows that the method can detect a 7% increment of QT, a 5% increment of QTcF, and a 4% ..
  81. Bjarnason N, Rode L, Dalhoff K. Fetal exposure to pimozide: a case report. J Reprod Med. 2006;51:443-4 pubmed
    b>Pimozide is an antidopaminergic, antipsychotic drug. Exposure during human pregnancy has not been reported previously, and recommendations on its use are based on extrapolation from other antipsychotics with antidopaminergic activity...
  82. Oruch R, Hodneland E, Pryme I, Holmsen H. Psychotropic drugs interfere with the tight coupling of polyphosphoinositide cycle metabolites in human platelets: a result of receptor-independent drug intercalation in the plasma membrane?. Biochim Biophys Acta. 2008;1778:2165-76 pubmed publisher
    ..Prochlorperazine (PCP), trifluoperazine (TFP), haloperidol (HPD), quetiapine (QTP), pimozide (PMZ) and clozapine (CLO) interfered with this tight coupling produced by treating platelets with increasing ..
  83. Aitken R, McLaughlin E. Molecular mechanisms of sperm capacitation: progesterone-induced secondary calcium oscillations reflect the attainment of a capacitated state. Soc Reprod Fertil Suppl. 2007;63:273-93 pubmed
    ..secondary calcium oscillations in pentoxifylline-treated cells, as did two inhibitors of T-type calcium channels (pimozide and amiloride)...
  84. Ladizinski B, Busse K, Bhutani T, Koo J. Aripiprazole as a viable alternative for treating delusions of parasitosis. J Drugs Dermatol. 2010;9:1531-2 pubmed
    ..Historically, pimozide, a first-generation antipsychotic, has been the treatment of choice for DOP, although there is risk for serious ..
  85. Collins L, Galtieri D, Brennum L, Sager T, Hockemeyer J, Muller C, et al. Oral tremor induced by the muscarinic agonist pilocarpine is suppressed by the adenosine A2A antagonists MSX-3 and SCH58261, but not the adenosine A1 antagonist DPCPX. Pharmacol Biochem Behav. 2010;94:561-9 pubmed publisher
    ..5mg/kg dose of the cholinomimetic pilocarpine or the DA D2 antagonist pimozide, indicating that the tremorolytic effects of adenosine antagonists may be receptor subtype specific...
  86. Zarazaga L, Celi I, Guzmán J, Malpaux B. The effect of nutrition on the neural mechanisms potentially involved in melatonin-stimulated LH secretion in female Mediterranean goats. J Endocrinol. 2011;211:263-72 pubmed publisher
    ..Plasma LH concentrations were measured twice per week. The effects of i.v. injections of naloxone, pimozide, cyproheptadine and N-methyl-d,l-aspartate (NMDA) on LH secretion were assessed the day before melatonin ..
  87. Bourgeois M, Nguyen Lan A. [Ekbom's syndrome and delusion of skin infestation. 1. Review of the literature]. Ann Med Psychol (Paris). 1986;144:321-40 pubmed
  88. Beato R, Maia D, Teixeira A, Cardoso F. Executive functioning in adult patients with Sydenham's chorea. Mov Disord. 2010;25:853-7 pubmed publisher
    ..Patients with SC have impairment in Tower of London task, reduced verbal fluency, and lower scores in the Stroop test. A subset of adult patients with SC present with executive dysfunction, even when chorea is in remission...