mebendazole

Summary

Summary: A benzimidazole that acts by interfering with CARBOHYDRATE METABOLISM and inhibiting polymerization of MICROTUBULES.

Top Publications

  1. Dayan A. Albendazole, mebendazole and praziquantel. Review of non-clinical toxicity and pharmacokinetics. Acta Trop. 2003;86:141-59 pubmed
    The pharmacokinetics and toxicity of albendazole, mebendazole and praziquantel are extensively reviewed, drawing on original published work and reviews in the open scientific literature and on assessments by international agencies and ..
  2. Doudican N, Rodriguez A, Osman I, Orlow S. Mebendazole induces apoptosis via Bcl-2 inactivation in chemoresistant melanoma cells. Mol Cancer Res. 2008;6:1308-15 pubmed publisher
    ..Strikingly, 4 of the 10 compounds (mebendazole, albendazole, fenbendazole, and oxybendazole) are benzimidazoles, a class of structurally related, tubulin-..
  3. Rodríguez García R, Rodríguez Guzmán L, Cruz del Castillo A. [Effectiveness and safety of mebendazole compared to nitazoxanide in the treatment of Giardia lamblia in children]. Rev Gastroenterol Mex. 1999;64:122-6 pubmed
    Compare the effectiveness and safety of mebendazole versus nitazoxanide in the treatment of Giardia lamblia in children...
  4. Smith J, Brooker S. Impact of hookworm infection and deworming on anaemia in non-pregnant populations: a systematic review. Trop Med Int Health. 2010;15:776-95 pubmed publisher
    ..hookworm infection and anaemia and to quantify the impact of treatment with the benzimidazoles, albendazole and mebendazole, on haemoglobin and anaemia in non-pregnant populations...
  5. Davila Gutierrez C, Vasquez C, Trujillo Hernández B, Huerta M. Nitazoxanide compared with quinfamide and mebendazole in the treatment of helminthic infections and intestinal protozoa in children. Am J Trop Med Hyg. 2002;66:251-4 pubmed
    ..The present study was carried out to evaluate the effectiveness of nitazoxanide compared with that of quinfamide, mebendazole, or both in the treatment of intestinal protozoa and helminthic infections...
  6. Moreno L, Alvarez L, Mottier L, Virkel G, Bruni S, Lanusse C. Integrated pharmacological assessment of flubendazole potential for use in sheep: disposition kinetics, liver metabolism and parasite diffusion ability. J Vet Pharmacol Ther. 2004;27:299-308 pubmed
    ..The data on FLBZ pharmacological behaviour presented here contribute to evaluate its potential to be developed as an anthelmintic for broad spectrum parasite control in ruminants...
  7. Soukhathammavong P, Sayasone S, Phongluxa K, Xayaseng V, Utzinger J, Vounatsou P, et al. Low efficacy of single-dose albendazole and mebendazole against hookworm and effect on concomitant helminth infection in Lao PDR. PLoS Negl Trop Dis. 2012;6:e1417 pubmed publisher
    Albendazole and mebendazole are increasingly deployed for preventive chemotherapy targeting soil-transmitted helminth (STH) infections...
  8. Krishnaiah Y, Veer Raju P, Dinesh Kumar B, Satyanarayana V, Karthikeyan R, Bhaskar P. Pharmacokinetic evaluation of guar gum-based colon-targeted drug delivery systems of mebendazole in healthy volunteers. J Control Release. 2003;88:95-103 pubmed
    The pharmacokinetic evaluation of guar gum-based colon-targeted tablets of mebendazole against an immediate release tablet was carried out in human volunteers...
  9. Phommasack B, Saklokham K, Chanthavisouk C, Nakhonesid Fish V, Strandgaard H, Montresor A, et al. Coverage and costs of a school deworming programme in 2007 targeting all primary schools in Lao PDR. Trans R Soc Trop Med Hyg. 2008;102:1201-6 pubmed publisher
    ..The Lao Government has addressed the problem by organizing regular anthelminthic chemotherapy with mebendazole 500mg for school and pre-school children in conjunction with health education activities incorporated into the ..

More Information

Publications62

  1. Kudo N, Kubota H, Gotoh H, Ishida H, Ikadai H, Oyamada T. Efficacy of thiabendazole, mebendazole, levamisole and ivermectin against gullet worm, Gongylonema pulchrum: in vitro and in vivo studies. Vet Parasitol. 2008;151:46-52 pubmed
    In vitro and in vivo studies were conducted to evaluate the effects of thiabendazole, mebendazole, levamisole and ivermectin against Gongylonema pulchrum...
  2. Sasaki J, Ramesh R, Chada S, Gomyo Y, Roth J, Mukhopadhyay T. The anthelmintic drug mebendazole induces mitotic arrest and apoptosis by depolymerizing tubulin in non-small cell lung cancer cells. Mol Cancer Ther. 2002;1:1201-9 pubmed
    ..In this study, we assess mebendazole (MZ), a microtubule-disrupting anthelmintic that exhibits a potent antitumor property both in vitro and in vivo...
  3. Olsen A, Namwanje H, Nejsum P, Roepstorff A, Thamsborg S. Albendazole and mebendazole have low efficacy against Trichuristrichiura in school-age children in Kabale District, Uganda. Trans R Soc Trop Med Hyg. 2009;103:443-6 pubmed publisher
    ..groups of Trichuris trichiura-infected school-age children were treated with one dose 400mg albendazole, 100mg mebendazole twice daily for 3 d, or 100mg mebendazole twice daily for 5 d...
  4. García Rodriguez J, de la Torre Iglesias P, Vegas Sánchez M, Torrado Durán S, Bolas Fernandez F, Torrado Santiago S. Changed crystallinity of mebendazole solid dispersion: improved anthelmintic activity. Int J Pharm. 2011;403:23-8 pubmed publisher
    To improve the efficacy of mebendazole (MBZ), a poorly water-soluble drug, MBZ solid dispersions containing different proportions of low-substituted hydroxypropylcellulose (L-HPC) were prepared by lyophilization process...
  5. Albonico M, Ramsan M, Wright V, Jape K, Haji H, Taylor M, et al. Soil-transmitted nematode infections and mebendazole treatment in Mafia Island schoolchildren. Ann Trop Med Parasitol. 2002;96:717-26 pubmed
    ..americanus was more prevalent. This survey was followed by a parasitological evaluation of mebendazole treatment using a single, 500-mg dose...
  6. Mukhopadhyay T, Sasaki J, Ramesh R, Roth J. Mebendazole elicits a potent antitumor effect on human cancer cell lines both in vitro and in vivo. Clin Cancer Res. 2002;8:2963-9 pubmed
    We have found that mebendazole (MZ), a derivative of benzimidazole, induces a dose- and time-dependent apoptotic response in human lung cancer cell lines...
  7. Chesnaye N, Sinuon M, Socheat D, Koporc K, Mathieu E. Treatment coverage survey after a school-based mass distribution of mebendazole: Kampot Province, Cambodia. Acta Trop. 2011;118:21-6 pubmed publisher
    ..helminth (STH) infections in school age children (SAC, 6-14 years old), Children Without Worms donates mebendazole to 8 countries with high prevalence of STH infections...
  8. Kadry Z, Renner E, Bachmann L, Attigah N, Renner E, Ammann R, et al. Evaluation of treatment and long-term follow-up in patients with hepatic alveolar echinococcosis. Br J Surg. 2005;92:1110-6 pubmed
  9. Escobedo A, Canete R, Gonzalez M, Pareja A, Cimerman S, Almirall P. A randomized trial comparing mebendazole and secnidazole for the treatment of giardiasis. Ann Trop Med Parasitol. 2003;97:499-504 pubmed
    ..children (aged 5-15 years) with confirmed Giardia lamblia infection were randomly allotted to treatment with mebendazole (200 mg three times daily for 3 days) or secnidazole (30 mg/kg, in a single dose)...
  10. Legesse M, Erko B, Medhin G. Comparative efficacy of albendazole and three brands of mebendazole in the treatment of ascariasis and trichuriasis. East Afr Med J. 2004;81:134-8 pubmed
    ..the comparative efficacy of 400 mg albendazole (Smith Kline Beecham) as a single dose and three brands of mebendazole (Janssen, Unibios and East African Pharmaceuticals) at doses of 100 mg twice a day for three consecutive days ..
  11. Baliharová V, Velik J, Savlík M, Szotakova B, Lamka J, Tahotná L, et al. The effects of fenbendazole, flubendazole and mebendazole on activities of hepatic cytochromes P450 in pig. J Vet Pharmacol Ther. 2004;27:85-90 pubmed
    Fenbendazole (FBZ), flubendazole (FLBZ) and mebendazole (MBZ) are benzimidazole anthelmintics widely used in veterinary medicine...
  12. Diav Citrin O, Shechtman S, Arnon J, Lubart I, Ornoy A. Pregnancy outcome after gestational exposure to mebendazole: a prospective controlled cohort study. Am J Obstet Gynecol. 2003;188:282-5 pubmed
    b>Mebendazole is an anthelmintic that is commonly needed in women of reproductive age. Its use in pregnancy is a reason for concern for women and their health care providers...
  13. de Silva N, Sirisena J, Gunasekera D, Ismail M, de Silva H. Effect of mebendazole therapy during pregnancy on birth outcome. Lancet. 1999;353:1145-9 pubmed
    In areas endemic for hookworm, routine antenatal mebendazole therapy could greatly reduce the prevalence of anaemia in pregnancy...
  14. De Clercq D, Sacko M, Behnke J, Gilbert F, Dorny P, Vercruysse J. Failure of mebendazole in treatment of human hookworm infections in the southern region of Mali. Am J Trop Med Hyg. 1997;57:25-30 pubmed
    Preliminary studies indicated that single-dose (500 mg) mebendazole gave disappointing results in the treatment of hookworm infections (Necator americanus) in Mali...
  15. Shikiya K, Zaha O, Niimura S, Ikema M, Nakamura H, Nakayoshi T, et al. [Long term eradication rate of mebendazole therapy for strongyloidiasis]. Kansenshogaku Zasshi. 1992;66:354-9 pubmed
    We treated 245 strongyloidiasis patients with 7 schedules of mebendazole (MBZ) and obtained the eradication rates at 8 months to 2 years after the final treatment as described follows; MBZ (100 mg) was given twice a day orally...
  16. Knopp S, Mohammed K, Speich B, Hattendorf J, Khamis I, Khamis A, et al. Albendazole and mebendazole administered alone or in combination with ivermectin against Trichuris trichiura: a randomized controlled trial. Clin Infect Dis. 2010;51:1420-8 pubmed publisher
    Single-dose albendazole and mebendazole show limited efficacy in the treatment of trichuriasis...
  17. Fan P, Wu C, Huang P, Yen C. Determination of the minmum effective dosages of praziquantel, albendazole, and mebendazole against Clonorchis sinensis infection in rats. Kaohsiung J Med Sci. 2005;21:448-51 pubmed
    In order to determine the minimum effective dosages of praziquantel, albendazole, and mebendazole against Clonorchis sinensis infection in Sprague-Dawley rats, each rat was infected with 30 metacercariae and treated with one of three ..
  18. Dobrosotskaya I, Hammer G, Schteingart D, Maturen K, Worden F. Mebendazole monotherapy and long-term disease control in metastatic adrenocortical carcinoma. Endocr Pract. 2011;17:e59-62 pubmed publisher
    ..To describe successful long-term tumor control in metastatic adrenocortical carcinoma, a relatively rare tumor with limited treatment options outside of surgery...
  19. Locatelli C, Pedrosa R, De Bem A, Creczynski Pasa T, Cordova C, Wilhelm Filho D. A comparative study of albendazole and mebendazole-induced, time-dependent oxidative stress. Redox Rep. 2004;9:89-95 pubmed
    Albendazole (ABZ) and mebendazole (MBZ) are two benzimidazole-derived drugs that show remarkable antihelmintic activity and are widely used in the treatment and control of helminths...
  20. de Villiers M, Terblanche R, Liebenberg W, Swanepoel E, Dekker T, Song M. Variable-temperature X-ray powder diffraction analysis of the crystal transformation of the pharmaceutically preferred polymorph C of mebendazole. J Pharm Biomed Anal. 2005;38:435-41 pubmed
    b>Mebendazole is a common benzimidazole anthelmintic that is water insoluble. It is reported to exist in three different polymorphic forms in the solid state, i.e. polymorph A, B and C...
  21. Kaya Z, Gursel T. A pediatric case of disseminated cystic echinococcosis successfully treated with mebendazole. Jpn J Infect Dis. 2004;57:7-9 pubmed
    ..b>Mebendazole therapy produced complete resolution of the lung and kidney cysts...
  22. Kumar S, Chawla G, Bansal A. Spherical crystallization of mebendazole to improve processability. Pharm Dev Technol. 2008;13:559-68 pubmed
    ..The present study was focused on spherical crystallization of an antihelmentic drug - Mebendazole (MBZ) - using spherical agglomeration technique...
  23. Ammari F, Omari A. Surgery and postoperative mebendazole in the treatment of hydatid disease. Saudi Med J. 2002;23:568-71 pubmed
    ..Our aim is to establish the outcome of chemotherapy in the postoperative period on secondary hydatid cyst...
  24. Krishnaiah Y, Veer Raju P, Dinesh Kumar B, Bhaskar P, Satyanarayana V. Development of colon targeted drug delivery systems for mebendazole. J Control Release. 2001;77:87-95 pubmed
    The objective of the present study is to develop colon targeted drug delivery systems for mebendazole using guar gum as a carrier...
  25. Adugna S, Kebede Y, Moges F, Tiruneh M. Efficacy of mebendazole and albendazole for Ascaris lumbricoides and hookworm infections in an area with long time exposure for antihelminthes, Northwest Ethiopia. Ethiop Med J. 2007;45:301-6 pubmed
    The efficacy of mebendazole and albendazole in the treatment of Ascaris lumbricoides and hookworm infections was evaluated in school children in an area with long time exposure for broad spectrum anthelminthic drugs.
  26. Vutova K, Mechkov G, Vachkov P, Petkov R, Georgiev P, Handjiev S, et al. Effect of mebendazole on human cystic echinococcosis: the role of dosage and treatment duration. Ann Trop Med Parasitol. 1999;93:357-65 pubmed
    Fifty-three patients with single, multiple and/or multi-organ hydatid cysts were treated with mebendazole, in varying dosages (30-70 mg/kg.day) and over varying periods (6-24 months)...
  27. Canete R, Escobedo A, Gonzalez M, Almirall P. Randomized clinical study of five days apostrophe therapy with mebendazole compared to quinacrine in the treatment of symptomatic giardiasis in children. World J Gastroenterol. 2006;12:6366-70 pubmed
    To compare the efficacy and safety of five days apostrophe therapy of mebendazole (MBZ) versus quinacrine (QC) on human giardiasis in children.
  28. Chotmongkol V, Sawadpanitch K, Sawanyawisuth K, Louhawilai S, Limpawattana P. Treatment of eosinophilic meningitis with a combination of prednisolone and mebendazole. Am J Trop Med Hyg. 2006;74:1122-4 pubmed
    To study the efficacy of the combination of prednisolone and mebendazole for the treatment of eosinophilic meningitis, we conducted a pilot study among Thai patients with eosinophilic meningitis...
  29. Bai R, Staedtke V, Aprhys C, Gallia G, Riggins G. Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme. Neuro Oncol. 2011;13:974-82 pubmed publisher
    ..Subsequent in vitro and in vivo experiments with benzimidazoles identified mebendazole as the more promising drug for GBM therapy...
  30. Yang Y, Vuitton D, Jones M, Craig P, McManus D. Brain metastasis of alveolar echinococcosis in a hyperendemic focus of Echinococcus multilocularis infection. Trans R Soc Trop Med Hyg. 2005;99:937-41 pubmed
    ..pregnancy, which may be suspected in this case, the favourable outcome after surgery and chemotherapy, and also a mental disability in a child following long-term intrauterine exposure to mebendazole, make the report particularly unique.
  31. Smego R, Bhatti S, Khaliq A, Beg M. Percutaneous aspiration-injection-reaspiration drainage plus albendazole or mebendazole for hepatic cystic echinococcosis: a meta-analysis. Clin Infect Dis. 2003;37:1073-83 pubmed
    ..cystic echinococcosis treated with percutaneous aspiration-injection-reaspiration (PAIR) plus albendazole or mebendazole (group 1) with 952 era-matched historical control subjects undergoing surgical intervention (group 2)...
  32. Namwanje H, Kabatereine N, Olsen A. The acceptability and safety of praziquantel alone and in combination with mebendazole in the treatment of Schistosoma mansoni and soil-transmitted helminthiasis in children aged 1-4 years in Uganda. Parasitology. 2011;138:1586-92 pubmed publisher
    ..In addition, although mebendazole has been extensively used together with praziquantel against infections with schistosomiasis and soil-..
  33. Bennett A, Guyatt H. Reducing intestinal nematode infection: efficacy of albendazole and mebendazole. Parasitol Today. 2000;16:71-4 pubmed
    The widespread use of mebendazole and albendazole for treating intestinal nematode infections in human populations is raising concerns that careful monitoring pro- cedures should be in place to identify any emergence of drug resistance...
  34. Steinmann P, Utzinger J, Du Z, Jiang J, Chen J, Hattendorf J, et al. Efficacy of single-dose and triple-dose albendazole and mebendazole against soil-transmitted helminths and Taenia spp.: a randomized controlled trial. PLoS ONE. 2011;6:e25003 pubmed publisher
    ..helminth (STH) infections currently relies on the large-scale administration of single-dose oral albendazole or mebendazole. However, these treatment regimens have limited efficacy against hookworm and Trichuris trichiura in terms of ..
  35. Pozio E, Sacchini D, Sacchi L, Tamburrini A, Alberici F. Failure of mebendazole in the treatment of humans with Trichinella spiralis infection at the stage of encapsulating larvae. Clin Infect Dis. 2001;32:638-42 pubmed
    ..mice were collected from muscle biopsies performed at different times (from 1 day to 16 months) following the end of treatment, indicating the failure of mebendazole to kill Trichinella parasites when they are encapsulating in muscles.
  36. Stoltzfus R, Albonico M, Chwaya H, Tielsch J, Schulze K, Savioli L. Effects of the Zanzibar school-based deworming program on iron status of children. Am J Clin Nutr. 1998;68:179-86 pubmed
    ..n = 952), and 4 schools in which students received thrice-yearly deworming (n = 970) with 500 mg generic mebendazole. Schools were randomly selected for evaluation and allocated to program groups...
  37. Králová V, Hanusova V, Staňková P, Knoppová K, Cáňová K, Skalova L. Antiproliferative effect of benzimidazole anthelmintics albendazole, ricobendazole, and flubendazole in intestinal cancer cell lines. Anticancer Drugs. 2013;24:911-9 pubmed publisher
    ..The anthelmintic benzimidazole drugs ABZ and FLU show a significant cytostatic effect and potentiate the efficacy of PTX in intestinal cancer cells...
  38. Navarrete Vazquez G, Yépez L, Hernández Campos A, Tapia A, Hernández Luis F, Cedillo R, et al. Synthesis and antiparasitic activity of albendazole and mebendazole analogues. Bioorg Med Chem. 2003;11:4615-22 pubmed
    Albendazole (Abz) and Mebendazole (Mbz) analogues have been synthesized and in vitro tested against the protozoa Giardia lamblia, Trichomonas vaginalis and the helminths Trichinella spiralis and Caenorhabditis elegans...
  39. Maté L, Virkel G, Lifschitz A, Ballent M, Lanusse C. Hepatic and extra-hepatic metabolic pathways involved in flubendazole biotransformation in sheep. Biochem Pharmacol. 2008;76:773-83 pubmed publisher
    ..CBR substrates such as menadione and mebendazole (a non-fluoride analogue of FLBZ), inhibited this liver microsomal enzymatic reaction, which may confirm the ..
  40. Chen K, Twu S, Chang H, Lin R. Outbreak of Stevens-Johnson syndrome/toxic epidermal necrolysis associated with mebendazole and metronidazole use among Filipino laborers in Taiwan. Am J Public Health. 2003;93:489-92 pubmed
    ..This study sought to identify the risk factors associated with an outbreak of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) among Filipino laborers in Taiwan...
  41. Keiser J, Utzinger J. Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis. JAMA. 2008;299:1937-48 pubmed publisher
    ..Preventive chemotherapy is the mainstay of control, but only 4 drugs are available: albendazole, mebendazole, levamisole, and pyrantel pamoate.
  42. Swanepoel E, Liebenberg W, de Villiers M. Quality evaluation of generic drugs by dissolution test: changing the USP dissolution medium to distinguish between active and non-active mebendazole polymorphs. Eur J Pharm Biopharm. 2003;55:345-9 pubmed
    b>Mebendazole is practically insoluble in water and studies of its polymorphism has led to the identification and characterization of three polymorphic forms (A, B, C) displaying solubility and therapeutic differences that show that ..
  43. Savlík M, Polácková L, Szotakova B, Lamka J, Velik J, Skalova L. Activities of biotransformation enzymes in pheasant (Phasianus colchicus) and their modulation by in vivo administration of mebendazole and flubendazole. Res Vet Sci. 2007;83:20-6 pubmed
    ..biotransformation enzymes and modulation of their activities by anthelmintics flubendazole (FLBZ) and mebendazole (MBZ) were investigated in subcellular fractions that were prepared from liver and small intestine of control ..
  44. Acs N, Banhidy F, Puho E, Czeizel A. Population-based case-control study of mebendazole in pregnant women for birth outcomes. Congenit Anom (Kyoto). 2005;45:85-8 pubmed
    The objectives of the study was to check the embryotoxic-teratogenic and fetotoxic effect of mebendazole (Vermox; Richter, Budapest, Hungary) treatment during pregnancy...
  45. Albonico M, Bickle Q, Ramsan M, Montresor A, Savioli L, Taylor M. Efficacy of mebendazole and levamisole alone or in combination against intestinal nematode infections after repeated targeted mebendazole treatment in Zanzibar. Bull World Health Organ. 2003;81:343-52 pubmed
    To evaluate the efficacy of and resistance to mebendazole (500 mg) and levamisole (40 or 80 mg), alone or in combination, for the treatment of Ascaris lumbricoides, Trichuris trichiura and hookworm infections on Pemba Island - an area ..
  46. Bartoloni C, Tricerri A, Guidi L, Gambassi G. The efficacy of chemotherapy with mebendazole in human cystic echinococcosis: long-term follow-up of 52 patients. Ann Trop Med Parasitol. 1992;86:249-56 pubmed
    ..granulosus infection of the liver, lungs, bone and/or soft tissues were treated for several months with oral mebendazole (50-60 mg kg-1 day-1), in divided doses after fat-rich meals, either without surgery (WS), post-surgery (PS) or ..
  47. Ceballos L, Elissondo M, Bruni S, Denegri G, Alvarez L, Lanusse C. Flubendazole in cystic echinococcosis therapy: pharmaco-parasitological evaluation in mice. Parasitol Int. 2009;58:354-8 pubmed publisher
  48. de la Rosa J, Alvarez N, Gomez Priego A. Study of the reproductive capacity of Trichinella spiralis recovered from experimentally infected mice under-dosed with albendazole or mebendazole. Trop Biomed. 2007;24:93-7 pubmed
    ..of Trichinella spiralis recovered from experimentally infected mice under-dosed with albendazole (ALB) or mebendazole (MEB) was studied. Different groups of male C57/BL mice were infected with 10 +/- 0...
  49. Larocque R, Casapia M, Gotuzzo E, MacLean J, Soto J, Rahme E, et al. A double-blind randomized controlled trial of antenatal mebendazole to reduce low birthweight in a hookworm-endemic area of Peru. Trop Med Int Health. 2006;11:1485-95 pubmed
    To assess the effect on birthweight of antenatal mebendazole plus iron vs. placebo plus iron in a highly hookworm-endemic area.
  50. Sacko M, De Clercq D, Behnke J, Gilbert F, Dorny P, Vercruysse J. Comparison of the efficacy of mebendazole, albendazole and pyrantel in treatment of human hookworm infections in the southern region of Mali, West Africa. Trans R Soc Trop Med Hyg. 1999;93:195-203 pubmed
    A randomized, placebo-controlled trial of the efficacy of pyrantel (single dose 12.5 mg/kg bodyweight), mebendazole (single 500 mg dose) and albendazole (single 400 mg dose) in the treatment of hookworm infections (Necator americanus) ..
  51. Du W, Liao J, Fan C, Su K. Combined treatment with interleukin-12 and mebendazole lessens the severity of experimental eosinophilic meningitis caused by Angiostrongylus cantonensis in ICR mice. Infect Immun. 2003;71:3947-53 pubmed
    ..Mice were orally infected with 35 infective larvae. One group of mice were given a single dose of mebendazole (20 mg/kg of body weight) per os at various times and examined at 14 days postinfection (dpi) for worm recovery ..
  52. Mekonnen Z, Levecke B, Boulet G, Bogers J, Vercruysse J. Efficacy of different albendazole and mebendazole regimens against heavy-intensity Trichuris trichiura infections in school children, Jimma Town, Ethiopia. Pathog Glob Health. 2013;107:207-9 pubmed publisher
    ..Therefore, the objective of this study was to determine the efficacy of albendazole (ALB) and mebendazole (MBZ) administered randomly for 1 (ALB×1 and MBZ×1) or 2 days (ALB×2 and MBZ×2) to 385 school children with ..
  53. Nygren P, Fryknäs M, Agerup B, Larsson R. Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer. J Cancer Res Clin Oncol. 2013;139:2133-40 pubmed publisher
    ..In the present study, we screened a compound library containing 1,600 clinically used compounds with the aim to identify compounds, which potentially could be repositioned for colon cancer therapy...