azabicyclo compounds


Summary: Bicyclic bridged compounds that contain a nitrogen which has three bonds. The nomenclature indicates the number of atoms in each path around the rings, such as [2.2.2] for three equal length paths. Some members are TROPANES and BETA LACTAMS.

Top Publications

  1. Laskar S, Sánchez Sánchez L, López Ortiz M, López Muñoz H, Escobar Sánchez M, Sánchez A, et al. Multicomponent synthesis of some new (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-dithiocarbamates and their in vitro anti-proliferative activity against CaSki, MDA-MB-231 and SK-Lu-1 tumour cells as apoptosis inducing agents without necrosis. J Enzyme Inhib Med Chem. 2017;32:1129-1135 pubmed publisher
    ..Rapid chemical modifications of this lead are thus highly necessary for further investigation as a drug like safer antitumor candidate and also to achieve compounds with better activity profile. ..
  2. Flamm R, Stone G, Sader H, Jones R, Nichols W. Avibactam reverts the ceftazidime MIC90 of European Gram-negative bacterial clinical isolates to the epidemiological cut-off value. J Chemother. 2014;26:333-8 pubmed publisher
    ..No ECOFF has been defined for Enterobacter spp. however, it is 1 mg/l for Enterobacter aerogenes and Enterobacter cloacae. The presence of avibactam reverted the ceftazidime MIC(90) for Gram-negative bacteria to the ECOFF. ..
  3. Cai Z, Wang J, Ma J, Zhu X, Cai J, Yang G. Anaerobic Degradation Pathway of the Novel Chiral Insecticide Paichongding and Its Impact on Bacterial Communities in Soils. J Agric Food Chem. 2015;63:7151-60 pubmed publisher
    ..Both the rarefaction curves and Shannon-Wiener diversity index in anaerobic soils had significant difference after IPP application, and the community composition also differed at both the phyla and genus levels. ..
  4. Caravaca Fontan F, Jiménez Alvaro S, Marcen Letosa R, Fernández Rodriguez A, Rodríguez Navarro C. Ceftazidime-avibactam in urinary tract infections due to carbapenemase-producing Klebsiella in kidney transplantation. Nefrologia. 2015;35:412-3 pubmed publisher
  5. Yohn S, Gogoj A, Haque A, Lopez Cruz L, Haley A, Huxley P, et al. Evaluation of the effort-related motivational effects of the novel dopamine uptake inhibitor PRX-14040. Pharmacol Biochem Behav. 2016;148:84-91 pubmed publisher
  6. Jacobs D, DiTursi S, Ruh C, Sharma R, Claus J, Banjade R, et al. Combination treatment with extended-infusion ceftazidime/avibactam for a KPC-3-producing Klebsiella pneumoniae bacteraemia in a kidney and pancreas transplant patient. Int J Antimicrob Agents. 2016;48:225-7 pubmed publisher
  7. Raut S, Adhikari B. Ceftazidime-avibactam in ceftazidime-resistant infections. Lancet Infect Dis. 2016;16:997 pubmed publisher
  8. Rousselet M, Feuillet F, Gérardin M, Jolliet P, Hardouin J, Victorri Vigneau C. The French addictovigilance network clinical assessment: Z-drugs, true false twins. Expert Opin Drug Saf. 2017;16:1063-1069 pubmed publisher
    ..No subpopulation was highlighted for zopiclone. These results were in favour of a higher prevalence of physical and compulsive signs of dependence and of harmful consequences of dependence, with zolpidem than with zopiclone. ..
  9. Benoit Y, Mitchell R, Risueno R, Orlando L, Tanasijevic B, Boyd A, et al. Sam68 Allows Selective Targeting of Human Cancer Stem Cells. Cell Chem Biol. 2017;24:833-844.e9 pubmed publisher
    ..Our study identifies Sam68 as a regulator of human CSC vulnerability. ..

More Information


  1. Donvito G, Bagdas D, Toma W, Rahimpour E, Jackson A, Meade J, et al. The interaction between alpha 7 nicotinic acetylcholine receptor and nuclear peroxisome proliferator-activated receptor-? represents a new antinociceptive signaling pathway in mice. Exp Neurol. 2017;295:194-201 pubmed publisher
    ..These findings suggest that PPAR-? plays a key role in a putative antinociceptive ?7 nicotinic signaling pathway. ..
  2. Li Z, Li S, Hu L, Li F, Cheung A, Shao W, et al. MECHANISMS UNDERLYING ACTION OF XINMAILONG INJECTION, A TRADITIONAL CHINESE MEDICINE IN CARDIAC FUNCTION IMPROVEMENT. Afr J Tradit Complement Altern Med. 2017;14:241-252 pubmed publisher
    ..Our findings pave the ways to the better understandings of the therapeutic effects of XML on cardiovascular system. ..
  3. Manzoni L, Samela A, Barbini S, Cairati S, Penconi M, Arosio D, et al. 4-Connected azabicyclo[5.3.0]decane Smac mimetics-Zn2+ chelators as dual action antitumoral agents. Bioorg Med Chem Lett. 2017;27:2336-2344 pubmed publisher
    ..In particular, the linker connecting DPA with the ABD scaffold seems to influence cellular Zn2+-chelation, with longer lipophilic linkers/DAC 3c being the optimal choice. ..
  4. Jobert M, Poiseau E, Jähnig P, Schulz H, Kubicki S. Topographical analysis of sleep spindle activity. Neuropsychobiology. 1992;26:210-7 pubmed
    ..Both substances enhanced the sleep spindle activity recorded from the frontal and parietal electrodes, but this increase was more pronounced in the parietal brain region. ..
  5. Gentile I, Maraolo A, Borgia G. What is the role of the new ?-lactam/?-lactamase inhibitors ceftolozane/tazobactam and ceftazidime/avibactam?. Expert Rev Anti Infect Ther. 2016;14:875-8 pubmed publisher
  6. Yang C, Deng J. Utility of flumazenil in zopiclone overdose. Clin Toxicol (Phila). 2008;46:920-1 pubmed publisher
  7. Castón J, Lacort Peralta I, Martin Davila P, Loeches B, Tabares S, Temkin L, et al. Clinical efficacy of ceftazidime/avibactam versus other active agents for the treatment of bacteremia due to carbapenemase-producing Enterobacteriaceae in hematologic patients. Int J Infect Dis. 2017;59:118-123 pubmed publisher
    ..7% vs. 34.8%, respectively, p=0.031). CPE bacteremia is associated with high mortality in patients with hematologic malignancies. Ceftazidime/avibactam may be an effective alternative for treating these patients. ..
  8. Teller H, Fürstner A. Concise synthesis of the antidepressive drug candidate GSK1360707 by a highly enantioselective gold-catalyzed enyne cycloisomerization reaction. Chemistry. 2011;17:7764-7 pubmed publisher
  9. Gugliandolo A, Caio C, Mezzatesta M, Rifici C, Bramanti P, Stefani S, et al. Successful ceftazidime-avibactam treatment of MDR-KPC-positive Klebsiella pneumoniae infection in a patient with traumatic brain injury: A case report. Medicine (Baltimore). 2017;96:e7664 pubmed publisher
    ..Moreover, the patient did not show any relapses for up to 18 weeks. This case indicates that ceftazidime-avibactam monotherapy could be efficacious against KPC positive Klebsiella pneumoniae infections. ..