Summary: An ergot alkaloid (ERGOT ALKALOIDS) with uterine and VASCULAR SMOOTH MUSCLE contractile properties.

Top Publications

  1. Cheng T. Ergonovine test for coronary artery spasm. Int J Cardiol. 2007;114:249-50; author reply 251 pubmed
  2. Lokugamage A, Sullivan K, Niculescu I, Tigere P, Onyangunga F, El Refaey H, et al. A randomized study comparing rectally administered misoprostol versus Syntometrine combined with an oxytocin infusion for the cessation of primary post partum hemorrhage. Acta Obstet Gynecol Scand. 2001;80:835-9 pubmed
    ..01). This result had a greater than 80% power. Misoprostol performed better. 800 mcg misoprostol per rectum is effective at treating primary post partum hemorrhage. ..
  3. Moubarak A, Rosenkrans C, Johnson Z. Modulation of cytochrome P450 metabolism by ergonovine and dihydroergotamine. Vet Hum Toxicol. 2003;45:6-9 pubmed
    This study investigated modulation of the cytochrome P450 3A (CYP3A4)-mediated metabolism of ergotamine (ET) by ergonovine and dihydroergotamine. Liver microsomes were prepared from rats treated i.p...
  4. Sueda S, Kohno H, Fukuda H, Ochi N, Kawada H, Hayashi Y, et al. Induction of coronary artery spasm by two pharmacological agents: comparison between intracoronary injection of acetylcholine and ergonovine. Coron Artery Dis. 2003;14:451-7 pubmed
    ..the clinical usefulness for the induction of coronary artery spasm (CAS) between acetylcholine (ACh) and ergonovine (ER)...
  5. Sueda S, Kohno H, Fukuda H, Ochi N, Kawada H, Hayashi Y, et al. Frequency of provoked coronary spasms in patients undergoing coronary arteriography using a spasm provocation test via intracoronary administration of ergonovine. Angiology. 2004;55:403-11 pubmed
    ..are no data concerning the incidence of provoked coronary arterial spasms via intracoronary administration of ergonovine (ER)...
  6. Koizumi T, Yokoyama M, Namikawa S, Kuriyama N, Nameki M, Nakayama T, et al. Location of focal vasospasm provoked by ergonovine maleate within coronary arteries in patients with vasospastic angina pectoris. Am J Cardiol. 2006;97:1322-5 pubmed
    ..coronary arteries, vasospasm was provoked in 82 patients with 92 lesions (42 focal, 50 diffuse) by intravenous ergonovine maleate injection...
  7. Ito T, Terashima M, Kaneda H, Nasu K, Ehara M, Kinoshita Y, et al. In vivo assessment of ergonovine-induced coronary artery spasm by 64-slice multislice computed tomography. Circ Cardiovasc Imaging. 2012;5:226-32 pubmed publisher
    ..The aim of this study was to investigate whether the morphological features observed on MSCT at the site of ergonovine-induced epicardial spasm could be used as diagnostic criteria for coronary spasm...
  8. Song J, Park S, Kang D, Hong M, Kim J, Lee C, et al. Safety and clinical impact of ergonovine stress echocardiography for diagnosis of coronary vasospasm. J Am Coll Cardiol. 2000;35:1850-6 pubmed
    ..The safety of ergonovine provocation for CVS performed outside the catheterization laboratory has been questioned...
  9. Brucker M. Management of the third stage of labor: an evidence-based approach. J Midwifery Womens Health. 2001;46:381-92 pubmed

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  1. Ng P, Chan A, Sin W, Tang L, Cheung K, Yuen P. A multicentre randomized controlled trial of oral misoprostol and i.m. syntometrine in the management of the third stage of labour. Hum Reprod. 2001;16:31-35 pubmed
    ..Oral misoprostol might be used in the management of the third stage, especially in situations where the use of syntometrine is contraindicated and facilities for storage and parenteral administration of oxytocics are limited. ..
  2. Choy C, Lau W, Tam W, Yuen P. A randomised controlled trial of intramuscular syntometrine and intravenous oxytocin in the management of the third stage of labour. BJOG. 2002;109:173-7 pubmed
    ..There are no important clinical differences in the effectiveness of intramuscular syntometrine and intravenous oxytocin for the prevention of postpartum blood loss. Intravenous oxytocin is less likely to cause hypertension. ..
  3. Noda T, Shimizu W, Taguchi A, Satomi K, Suyama K, Kurita T, et al. ST-segment elevation and ventricular fibrillation without coronary spasm by intracoronary injection of acetylcholine and/or ergonovine maleate in patients with Brugada syndrome. J Am Coll Cardiol. 2002;40:1841-7 pubmed
    ..elevation in leads V(1) to V(3), and induction of VF by intracoronary injection of acetylcholine (ACh) and/or ergonovine maleate (EM) in 27 symptomatic patients with Brugada syndrome and 30 control subjects...
  4. Citro R, Pascotto M, Provenza G, Gregorio G, Bossone E. Transient left ventricular ballooning (tako-tsubo cardiomyopathy) soon after intravenous ergonovine injection following caesarean delivery. Int J Cardiol. 2010;138:e31-4 pubmed publisher
    ..never reported before of transient left ventricular ballooning occurring during the early postpartum period after ergonovine injection rapidly evolving from a 'typical apical' ballooning into a 'midventricular' myocardial dysfunction.
  5. Hong Y, Jeong M, Choi Y, Ma E, Ko J, Lee M, et al. Plaque components at coronary sites with focal spasm in patients with variant angina: virtual histology-intravascular ultrasound analysis. Int J Cardiol. 2010;144:367-72 pubmed publisher
    We compared the plaque components at coronary sites with focal spasm after ergonovine provocation test in 30 variant angina (VA) patients with those at culprit coronary sites in 32 unstable angina (UA) patients using virtual histology-..
  6. Coma Canella I, Castano S, Macias A, Calabuig J, Artaiz M. Ergonovine test in angina with normal coronary arteries. Is it worth doing it?. Int J Cardiol. 2006;107:200-6 pubmed
    ..Increasing doses of ergonovine (from 1 to 30 microg) were injected into the coronary arteries to provoke coronary spasm...
  7. Sueda S, Kohno H, Fukuda H, Ochi N, Kawada H, Hayashi Y, et al. Clinical impact of selective spasm provocation tests: comparisons between acetylcholine and ergonovine in 1508 examinations. Coron Artery Dis. 2004;15:491-7 pubmed
    There are few reports regarding the concordance of coronary arterial response between acetylcholine (ACh) and ergonovine (ER) spasm provocation tests.
  8. Nishizawa S, Shiraishi J, Torii S, Miyagawa K, Arihara M, Hadase M, et al. Intermediate fixed coronary artery stenosis at the site of ergonovine-provoked spasm as a predictor of long-term major adverse cardiac events of patients with coronary spastic angina. Circ J. 2009;73:699-704 pubmed
  9. Aramide T, Olusegun A, Akinfolarin A, Oriola D. Oral misoprostol in the prevention of uterine bleeding after surgical evacuation of first trimester abortion: a comparative study of three uterotonic agents. Niger J Clin Pract. 2014;17:10-3 pubmed publisher
    ..7% and 57.1%, respectively) compared with the Oxytocin group. Oral Misoprostol appeared to demonstrate superior efficacy in reducing uterine bleeding after surgical evacuation, compared to the other commonly used uterotonic agents. ..
  10. van Dongen P, de Groot A. History of ergot alkaloids from ergotism to ergometrine. Eur J Obstet Gynecol Reprod Biol. 1995;60:109-16 pubmed
    ..However, because of severe and unpredictable side effects and the instability of the drug, ergometrine is not the drug of choice for either the prevention or the treatment of postpartum haemorrhage...
  11. Storm I, Rasmussen P, Strobel B, Hansen H. Ergot alkaloids in rye flour determined by solid-phase cation-exchange and high-pressure liquid chromatography with fluorescence detection. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008;25:338-46 pubmed publisher
    ..It is capable of separating and quantifying both C8-isomers of ergocornine, alpha-ergocryptine, ergocristine, ergonovine, and ergotamine. The average recovery was 61% +/- 10% with limits of detection from 0.2 to 1.1 microg kg(-1)...
  12. Paulke A, Kremer C, Wunder C, Achenbach J, Djahanschiri B, Elias A, et al. Argyreia nervosa (Burm. f.): receptor profiling of lysergic acid amide and other potential psychedelic LSD-like compounds by computational and binding assay approaches. J Ethnopharmacol. 2013;148:492-7 pubmed publisher
    ..However, vegetative side effects and psychotropic effects may be triggered by serotonin or dopamine receptor subtypes. ..
  13. Chuang S. Finger ischemia secondary to the synergistic agonist effect of norepinephrine and ergonovine and in a burn patient. Burns. 2003;29:92-4 pubmed
  14. de Groot A, van Dongen P, Vree T, Hekster Y, van Roosmalen J. Ergot alkaloids. Current status and review of clinical pharmacology and therapeutic use compared with other oxytocics in obstetrics and gynaecology. Drugs. 1998;56:523-35 pubmed
    Ergot alkaloids are well known preparations. Ergot alkaloids used in obstetrics and gynaecology are ergometrine (ergonovine; EM), methylergometrine (methergine; ME) and bromocriptine. The pharmaceutical properties of ME EM) are critical...
  15. Cheng C, Yang N, Lin K, Hung M, Cherng W. Role of coronary spasm for a positive noninvasive stress test result in angina pectoris patients without hemodynamically significant coronary artery disease. Am J Med Sci. 2008;335:354-62 pubmed publisher
    ..Intracoronary ergonovine testing induced coronary spasm in over 50% of patients who had suspected ischemic chest pain, a positive ..
  16. Browning R, Leite Browning M, Smith H, Wakefield T. Effect of ergotamine and ergonovine on plasma concentrations of thyroid hormones and cortisol in cattle. J Anim Sci. 1998;76:1644-50 pubmed
    ..In Exp. 1, seven Angus steers (294 kg) received i.v. bolus injections of saline (SAL), ergonovine maleate (7 mg; EM), or ergotamine tartrate (7 mg; ET) at weekly intervals, and they received all treatments ..
  17. Ushiroyama T, Sakuma K, Souen H, Nakai G, Morishima S, Yasuda K, et al. Therapeutic effects of Kyuki-chouketsu-in in restoring postpartum physical condition. Am J Chin Med. 2003;31:437-44 pubmed
    ..Kyuki-chouketsu-in can be expected to improve the health of women in the postpartum period. Biopharmacological research and clinical trials to investigate the properties of this drug in detail are warranted. ..
  18. Hayashi Y, Ibe T, Kawato H, Futamura N, Koyabu S, Ikeda U, et al. Postpartum acute myocardial infarction induced by ergonovine administration. Intern Med. 2003;42:983-6 pubmed
    ..Myocardial infarction may be overlooked in young women in the early postpartum period. Careful monitoring and prompt evaluation should be performed when this drug is administered for obstetrical purposes. ..
  19. Malester B, Tong X, Ghiu I, Kontogeorgis A, Gutstein D, Xu J, et al. Transgenic expression of a dominant negative K(ATP) channel subunit in the mouse endothelium: effects on coronary flow and endothelin-1 secretion. FASEB J. 2007;21:2162-72 pubmed
    ..There was no evidence of increased susceptibility to ergonovine-induced coronary vasospasm...
  20. Shiomi M, Ishida T, Kobayashi T, Nitta N, Sonoda A, Yamada S, et al. Vasospasm of atherosclerotic coronary arteries precipitates acute ischemic myocardial damage in myocardial infarction-prone strain of the Watanabe heritable hyperlipidemic rabbits. Arterioscler Thromb Vasc Biol. 2013;33:2518-23 pubmed publisher
    ..infarction-prone strain of the Watanabe heritable hyperlipidemic rabbits received an intravenous bolus of ergonovine maleate (0...
  21. Leung S, Ng P, Wong W, Cheung T. A randomised trial of carbetocin versus syntometrine in the management of the third stage of labour. BJOG. 2006;113:1459-64 pubmed
    ..It is less likely to induce hypertension and has a low incidence of adverse effect. It should be considered as a good alternative to conventional uterotonic agents used in managing the third stage of labour. ..
  22. Yun K, Shin S, Ko J, Rhee S, Kim N, Oh S, et al. Coronary artery responsiveness to ergonovine provocation in patients without vasospatic angina: a quantitative coronary angiography analysis. Int Heart J. 2011;52:338-42 pubmed
    Even patients without vasospastic angina show vasoconstriction after intracoronary ergonovine administration. We evaluated the determinants of coronary artery responsiveness to ergonovine in such patients...
  23. Lv Y, Zhang Z, Gong Z, Hu Y, He D. Determination and pharmacokinetics of ergometrine maleate in rabbit blood with on line microdialysis sampling and fluorescence detection. J Pharm Biomed Anal. 2005;38:29-33 pubmed
    ..9989) with a detection limit 0.3 ng ml-1 (3sigma). The pharmacokinetic parameters of ergometrine maleate were calculated utilizing the pharmacokinetic software 'NDST-21' by a one-compartmental open model. ..
  24. Dyer R, van Dyk D, Dresner A. The use of uterotonic drugs during caesarean section. Int J Obstet Anesth. 2010;19:313-9 pubmed publisher
    ..This review examines the adverse haemodynamic and side effects, and methods for their limitation. An approach to dosing and choices of agent for the limitation of postpartum haemorrhage is suggested. ..
  25. Su L, Chong Y, Samuel M. Carbetocin for preventing postpartum haemorrhage. Cochrane Database Syst Rev. 2012;:CD005457 pubmed publisher
    ..Further research is needed to analyse the cost-effectiveness of carbetocin as a uterotonic agent. ..
  26. Lehner A, Craig M, Fannin N, Bush L, Tobin T. Fragmentation patterns of selected ergot alkaloids by electrospray ionization tandem quadrupole mass spectrometry. J Mass Spectrom. 2004;39:1275-86 pubmed
    ..These assignments were supported by the lack of similar fragments from the water-soluble ergot ergonovine, which lacks a peptide ring system...
  27. Yasuda T, Iida R, Kawai Y, Nakajima T, Kominato Y, Fujihara J, et al. Serum deoxyribonuclease I can be used as a useful marker for diagnosis of death due to ischemic heart disease. Leg Med (Tokyo). 2009;11 Suppl 1:S213-5 pubmed publisher
    ..Similarly, it is suggested that serum DNase I could be potentially useful as a biochemical marker for diagnosis of death due to ischemic heart disease. ..
  28. Askar A, Ismail M, El Ezz A, Rabie N. Carbetocin versus syntometrine in the management of third stage of labor following vaginal delivery. Arch Gynecol Obstet. 2011;284:1359-65 pubmed publisher
    ..Single dose of intramuscular carbetocin 100 ?g may be more effective as compared to a single intramuscular dose of syntometrine in reducing postpartum blood loss with a smaller drop in hemoglobin levels and less adverse effects. ..
  29. Millaire A, Ducloux G, Marquand A, Vaksmann G. [Nitroglycerin and angina with angiographically normal coronary vessels. Clinical effects and effects on esophageal motility]. Arch Mal Coeur Vaiss. 1989;82:63-8 pubmed
    ..abstract truncated at 250 words) ..
  30. Lam H, Tang O, Lee C, Ho P. A pilot-randomized comparison of sublingual misoprostol with syntometrine on the blood loss in third stage of labor. Acta Obstet Gynecol Scand. 2004;83:647-50 pubmed
    ..Transient side effect such as fever and shivering which resolved within a day occurred more frequent to those who received sublingual misoprostol. ..
  31. Tousoulis D, McFadden E, Kaski J. Patterns of coronary artery stenosis vasomotion: observed versus "predicted" stenosis reactivity in patients with chronic stable angina. Coron Artery Dis. 1993;4:529-36 pubmed
    ..stenosis vasomotion in 52 patients with chronic stable angina (40 men and 12 women) who underwent intracoronary ergonovine or isosorbide dinitrate administration or both...
  32. Ha J, Lee J, Jang Y, Chung N, Kwan J, Rim S, et al. 123I-MIBG myocardial scintigraphy as a noninvasive screen for the diagnosis of coronary artery spasm. J Nucl Cardiol. 1998;5:591-7 pubmed
    ..Coronary arteriography and a provocative test with intravenous administration of ergonovine maleate were performed in 26 patients (20 men, 6 women, mean age 48.2+/-12...
  33. Coma Canella I, Martinez Caro D, Cosin Sales J, Fernandez Jarne E, Garcia Velloso M, Gimenez M. Clandestine ischemia in patients with vasospastic angina. Coron Artery Dis. 2000;11:383-90 pubmed
    ..Coronary angiography and then an intracoronary ergonovine test were performed for each patient...
  34. Chong Y, Chua S, El Refaey H, Choo W, Chanrachakul B, Tai B, et al. Postpartum intrauterine pressure studies of the uterotonic effect of oral misoprostol and intramuscular syntometrine. BJOG. 2001;108:41-7 pubmed
    ..At doses of 200 microg to 400 microg, oral misoprostol has a similar uterotonic effect to intramuscular syntometrine. Higher doses of oral misoprostol are associated with significantly more side effects. ..
  35. Lablanche J, Fourrier J, Gommeaux A, Mariotti R, Bertrand M. [Value of negative U waves in coronary artery spasm]. Arch Mal Coeur Vaiss. 1990;83:199-203 pubmed
    ..The recognition of a negative U wave increases the sensitivity of the electrocardiogram during resting angina and allows earlier treatment of coronary spasm with nitrate derivatives after an ergometrine test. ..
  36. Yaju Y, Kataoka Y, Eto H, Horiuchi S, Mori R. Prophylactic interventions after delivery of placenta for reducing bleeding during the postnatal period. Cochrane Database Syst Rev. 2013;:CD009328 pubmed publisher
    ..Trials to assess the effectiveness of herbal medicines and homeopathic remedies in preventing PPH are warranted. ..
  37. Westhoff G, Cotter A, Tolosa J. Prophylactic oxytocin for the third stage of labour to prevent postpartum haemorrhage. Cochrane Database Syst Rev. 2013;:CD001808 pubmed publisher
  38. Kang K, Choi S, Chun E, Kim J, Youn T, Choi D. Coronary vasospastic angina: assessment by multidetector CT coronary angiography. Korean J Radiol. 2012;13:27-33 pubmed publisher
    ..the accuracy of MDCTA in the identification of VA as compared with invasive coronary angiography with an ergonovine provocation test (CAG with an EG test)...
  39. Martinkova L, Kren V, Cvak L, Ovesn√° M, Prepechalov√° I. Hydrolysis of lysergamide to lysergic acid by Rhodococcus equi A4. J Biotechnol. 2001;84:63-6 pubmed
    ..From a mixture of lysergamide and its epimer isolysergamide, Rhodococcus equi A4 containing amidase preferentially hydrolyzed lysergamide into lysergic acid. ..
  40. Pavlova G. Effects of serotonin, dopamine and ergometrine on locomotion in the pulmonate mollusc Helix lucorum. J Exp Biol. 2001;204:1625-33 pubmed
    ..The efficiency of the serotonergic system depends on the physiological state of the mollusc (e.g. that characteristic of summer or winter). ..
  41. Goadsby P, Akerman S, Storer R. Evidence for postjunctional serotonin (5-HT1) receptors in the trigeminocervical complex. Ann Neurol. 2001;50:804-7 pubmed
    ..These data establish the existence of triptan-sensitive (5-HT1) receptors on postsynaptic central trigeminal neurones. ..
  42. Nedeljkovic M, Ostojic M, Beleslin B. Treatment of medically uncontrolled coronary artery spasm in the normal coronary artery with coronary stenting. J Invasive Cardiol. 2002;14:633-5 pubmed
    ..ventricular fibrillation and myocardial infarction, who was treated with coronary stenting at the site of ergonovine-induced coronary vasospasm where the coronary artery appeared angiographically normal, i.e...
  43. Orji E, Agwu F, Loto O, Olaleye O. A randomized comparative study of prophylactic oxytocin versus ergometrine in the third stage of labor. Int J Gynaecol Obstet. 2008;101:129-32 pubmed publisher
    ..0001). Oxytocin is as effective as ergometrine at reducing the incidence of postpartum hemorrhage, but without the undesirable side effects of nausea, vomiting, and elevated blood pressure associated with ergometrine. ..
  44. Lourens R, Paterson Brown S. Ergometrine given during caesarean section and incidence of delayed postpartum haemorrhage due to uterine atony. J Obstet Gynaecol. 2007;27:795-7 pubmed
    ..We feel this is reasonable and now use a prophylactic anti-emetic as well as delaying the ergometrine until closure of the rectus sheath which reduces the incidence of nausea and vomiting. ..
  45. Pavlova G. Muscular waves contribute to gliding rate in the freshwater gastropod Lymnaea stagnalis. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2010;196:241-8 pubmed publisher
  46. De Costa C. St Anthony's fire and living ligatures: a short history of ergometrine. Lancet. 2002;359:1768-70 pubmed
  47. Looper M, Edrington T, Moubarak A, Callaway T, Rosenkrans C. Effects of the ergot alkaloids dihydroergotamine, ergonovine, and ergotamine on growth of Escherichia coli O157:H7 in vitro. Foodborne Pathog Dis. 2008;5:599-604 pubmed publisher
    A series of experiments were conducted to evaluate the effects of ergot alkaloids (dihydroergotamine, ergonovine, and ergotamine) on E. coli O157:H7 in both pure and mixed ruminal fluid culture. Alkaloids were added to solutions of E...
  48. Browning R, Leite Browning M. Effect of ergotamine and ergonovine on thermal regulation and cardiovascular function in cattle. J Anim Sci. 1997;75:176-81 pubmed
    ..Nine Angus heifers received single i.v. injections of ergotamine tartrate, ergonovine maleate, and saline vehicle in a simple cross-over design...
  49. Ono S, Takeishi Y, Yamaguchi H, Abe S, Tachibana H, Sato T, et al. Enhanced regional washout of technetium-99m-sestamibi in patients with coronary spastic angina. Ann Nucl Med. 2003;17:393-8 pubmed
    ..During coronary arteriography, spasm was induced by provocation test with ergonovine, and only total or subtotal occlusion was considered positive...
  50. Cocks T, Kemp B, Pruneau D, Angus J. Comparison of contractile responses to 5-hydroxytryptamine and sumatriptan in human isolated coronary artery: synergy with the thromboxane A2-receptor agonist, U46619. Br J Pharmacol. 1993;110:360-8 pubmed
    ..The enhanced response is not specific for either sumatriptan or 5-HT,-like receptors since contractions to 5-HT, ergometrine and methysergide were also potentiated by U46619. ..
  51. Zachariah E, Naidu M, Seshadri L. Oral misoprostol in the third stage of labor. Int J Gynaecol Obstet. 2006;92:23-6 pubmed
    ..Oral misoprostol is as effective as conventional oxytocic agents in preventing postpartum hemorrhage and can be recommended for use in low-resource settings. ..
  52. Song J, Park S, Kang D, Hong M, Lee C, Song J, et al. Prognostic implication of ergonovine echocardiography in patients with near normal coronary angiogram or negative stress test for significant fixed stenosis. J Am Soc Echocardiogr. 2002;15:1346-52 pubmed
    The goal of this study was to assess the prognostic value of ergonovine echocardiography (Erg Echo) for diagnosis of coronary vasospasm (CVS) in patients without significant fixed coronary stenosis...
  53. Takagi Y, Yasuda S, Takahashi J, Tsunoda R, Ogata Y, Seki A, et al. Clinical implications of provocation tests for coronary artery spasm: safety, arrhythmic complications, and prognostic impact: multicentre registry study of the Japanese Coronary Spasm Association. Eur Heart J. 2013;34:258-67 pubmed publisher
    ..The provocation tests were performed with either acetylcholine (ACh, 57%) or ergonovine (40%). During the provocation tests, VT/VF and brady-arrhythmias developed at a rate of 3.2 and 2...