lincomycin

Summary

Summary: An antibiotic produced by Streptomyces lincolnensis var. lincolnensis. It has been used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections.

Top Publications

  1. Spizek J, Rezanka T. Lincomycin, clindamycin and their applications. Appl Microbiol Biotechnol. 2004;64:455-64 pubmed
    b>Lincomycin and clindamycin are lincosamide antibiotics used in clinical practice. Both antibiotics are bacteriostatic and inhibit protein synthesis in sensitive bacteria...
  2. Kobayashi H, Nakajima H, Shimizu Y, Eguchi M, Hata E, Yamamoto K. Macrolides and lincomycin susceptibility of Mycoplasma hyorhinis and variable mutation of domain II and V in 23S ribosomal RNA. J Vet Med Sci. 2005;67:795-800 pubmed
    ..strains (28 from weaned pigs and 3 from finishers) showed resistance to 16-membered macrolide antibiotics and lincomycin. The prevalence of the 16-membered macrolide-resistant M...
  3. Rajeswaran M, Srikrishnan T. Crystal and molecular structure and absolute configuration of lincomycin hydrochloride monohydrate. Carbohydr Res. 2004;339:2111-5 pubmed
    b>Lincomycin is a broad-spectrum antibiotic synthesized by Streptomyces lincolnensis that is particularly active against Gram-positive bacteria. It is widely used in human and veterinary applications...
  4. Sasaki E, Lin C, Lin K, Liu H. Construction of the octose 8-phosphate intermediate in lincomycin A biosynthesis: characterization of the reactions catalyzed by LmbR and LmbN. J Am Chem Soc. 2012;134:17432-5 pubmed publisher
    b>Lincomycin A is a potent antimicrobial agent noted for its unusual C1 methylmercapto-substituted 8-carbon sugar...
  5. Koussevitzky S, Nott A, Mockler T, Hong F, Sachetto Martins G, Surpin M, et al. Signals from chloroplasts converge to regulate nuclear gene expression. Science. 2007;316:715-9 pubmed
    ..We propose a model in which multiple indicators of aberrant plastid function in Arabidopsis are integrated upstream of GUN1 within plastids, which leads to ABI4-mediated repression of nuclear-encoded genes. ..
  6. Dousa M, Sikac Z, Halama M, Lemr K. HPLC determination of lincomycin in premixes and feedstuffs with solid-phase extraction on HLB OASIS and LC-MS/MS confirmation. J Pharm Biomed Anal. 2006;40:981-6 pubmed
    A rapid clean-up procedure based on solid-phase extraction (SPE) and HPLC determination of lincomycin in premixes with UV detection is described...
  7. Aarestrup F, Friis N. Antimicrobial susceptibility testing of Mycoplasma hyosynoviae isolated from pigs during 1968 to 1971 and during 1995 and 1996. Vet Microbiol. 1998;61:33-9 pubmed
    This study was conducted to compare the Minimal Inhibitory Concentrations (MICs) for enrofloxacin, lincomycin, tetracycline, tiamulin and tylosin, of Mycoplasma hyosynoviae, isolated from pigs at notably different intervals (1968-71 and ..
  8. Mateusen B, Maes D, Van Goubergen M, Verdonck M, de Kruif A. Effectiveness of treatment with lincomycin hydrochloride and/or vaccination against Mycoplasma hyopneumoniae for controlling chronic respiratory disease in a herd of pigs. Vet Rec. 2002;151:135-40 pubmed
    ..One group of 61 pigs received 220 ppm lincomycin hydrochloride in the feed from day 71 to day 91, a second group was vaccinated against M...
  9. Berry S, Read D, Walker R, Famula T. Clinical, histologic, and bacteriologic findings in dairy cows with digital dermatitis (footwarts) one month after topical treatment with lincomycin hydrochloride or oxytetracycline hydrochloride. J Am Vet Med Assoc. 2010;237:555-60 pubmed publisher
    To compare the effectiveness of lincomycin and oxytetracycline for treatment of digital dermatitis (DD) in dairy cows through gross visual examination, histologic evaluation, and bacteriologic evaluation.

More Information

Publications62

  1. Kumano M, Fujita M, Nakamura K, Murata M, Ohki R, Yamane K. Lincomycin resistance mutations in two regions immediately downstream of the -10 region of lmr promoter cause overexpression of a putative multidrug efflux pump in Bacillus subtilis mutants. Antimicrob Agents Chemother. 2003;47:432-5 pubmed
    We isolated 19 lincomycin-resistant Bacillus subtilis mutants by expressing lmrB encoding a putative multidrug efflux protein...
  2. Achard A, Villers C, Pichereau V, Leclercq R. New lnu(C) gene conferring resistance to lincomycin by nucleotidylation in Streptococcus agalactiae UCN36. Antimicrob Agents Chemother. 2005;49:2716-9 pubmed
    Streptococcus agalactiae UCN36 was resistant to lincomycin (MIC = 16 microg/ml) but susceptible to clindamycin (MIC = 0.12 microg/ml) and erythromycin (MIC = 0.06 microg/ml). A 4-kb HindIII fragment was cloned from S...
  3. Arimitsu H, Tsukamoto K, Ochi S, Sasaki K, Kato M, Taniguchi K, et al. Lincomycin-induced over-expression of mature recombinant cholera toxin B subunit and the holotoxin in Escherichia coli. Protein Expr Purif. 2009;67:96-103 pubmed publisher
    ..The E. coli strain MV1184 was transformed with each plasmid and then cultured in CAYE broth containing lincomycin. Recombinant CTB (rCTB) was purified from each cell extract...
  4. Kuchta S, Cessna A. Lincomycin and spectinomycin concentrations in liquid swine manure and their persistence during simulated manure storage. Arch Environ Contam Toxicol. 2009;57:1-10 pubmed publisher
    ..In the prairie region of Canada, lincomycin and spectinomycin are two antimicrobials that are frequently administered to pigs for prevention of post-weaning ..
  5. Kamenik Z, Kopecky J, Marečková M, Ulanova D, Novotna J, Pospísil S, et al. HPLC-fluorescence detection method for determination of key intermediates of the lincomycin biosynthesis in fermentation broth. Anal Bioanal Chem. 2009;393:1779-87 pubmed publisher
    The biosynthetic pathway of the clinically important antibiotic lincomycin is not known in details...
  6. Adams S, Fussell R, Dickinson M, Wilkins S, Sharman M. Study of the depletion of lincomycin residues in honey extracted from treated honeybee (Apis mellifera L.) colonies and the effect of the shook swarm procedure. Anal Chim Acta. 2009;637:315-20 pubmed publisher
    Bee colonies were treated with 1.2g lincomycin hydrochloride per hive (single treatment in sucrose solution) and samples of honey were then collected at intervals over a 41-week period...
  7. Loria G, Sammartino C, Nicholas R, Ayling R. In vitro susceptibilities of field isolates of Mycoplasma agalactiae to oxytetracycline, tylosin, enrofloxacin, spiramycin and lincomycin-spectinomycin. Res Vet Sci. 2003;75:3-7 pubmed
    The minimum inhibitory concentrations (MICs) of tetracycline, enrofloxacin, tylosin, spiramycin and a lincomycin:spectinomycin 1:2 combination, against 24 Sicilian isolates of Mycoplasma agalactiae, the causative organism of contagious ..
  8. Spizek J, Rezanka T. Lincomycin, cultivation of producing strains and biosynthesis. Appl Microbiol Biotechnol. 2004;63:510-9 pubmed
    b>Lincomycin and its derivatives are antibiotics exhibiting biological activity against Gram-positive bacteria. The semi-synthetic chlorinated lincomycin derivative is used in clinical practice...
  9. Andreozzi R, Canterino M, Lo Giudice R, Marotta R, Pinto G, Pollio A. Lincomycin solar photodegradation, algal toxicity and removal from wastewaters by means of ozonation. Water Res. 2006;40:630-8 pubmed
    ..b>Lincomycin, one of the most used in clinical practices whose presence in the STP effluents has been often documented, is ..
  10. Lyras D, Adams V, Ballard S, Teng W, Howarth P, Crellin P, et al. tISCpe8, an IS1595-family lincomycin resistance element located on a conjugative plasmid in Clostridium perfringens. J Bacteriol. 2009;191:6345-51 pubmed publisher
    ..b>Lincomycin resistance in C...
  11. Koberská M, Kopecky J, Olsovska J, Jelinkova M, Ulanova D, Man P, et al. Sequence analysis and heterologous expression of the lincomycin biosynthetic cluster of the type strain Streptomyces lincolnensis ATCC 25466. Folia Microbiol (Praha). 2008;53:395-401 pubmed publisher
    ..and several hundred point mutations were identified if compared with the previously published sequence of the lincomycin (Lin) industrial strain S. lincolnensis 78-11...
  12. Keswani N, Choudhary S, Kishore N. Interaction of weakly bound antibiotics neomycin and lincomycin with bovine and human serum albumin: biophysical approach. J Biochem. 2010;148:71-84 pubmed publisher
    The thermodynamics of interaction of neomycin and lincomycin with bovine serum albumin (BSA) and human serum albumin (HSA) has been studied using isothermal titration calorimetry (ITC), in combination with UV-visible, steady state and ..
  13. Novotna J, Honzatko A, Bednar P, Kopecky J, Janata J, Spizek J. l-3,4-Dihydroxyphenyl alanine-extradiol cleavage is followed by intramolecular cyclization in lincomycin biosynthesis. Eur J Biochem. 2004;271:3678-83 pubmed
    The LmbB1 protein, participating in the biosynthesis of lincomycin, was heterologously expressed in Escherichia coli, purified in its active form, and characterized as a dimer of identical subunits...
  14. Ulanova D, Novotna J, Smutná Y, Kamenik Z, Gažák R, Sulc M, et al. Mutasynthesis of lincomycin derivatives with activity against drug-resistant staphylococci. Antimicrob Agents Chemother. 2010;54:927-30 pubmed publisher
    The lincomycin biosynthetic gene lmbX was deleted in Streptomyces lincolnensis ATCC 25466, and deletion of this gene led to abolition of lincomycin production...
  15. Wu Y, Ye S, Hu S. Electrochemical study of lincomycin on a multi-wall carbon nanotubes modified glassy carbon electrode and its determination in tablets. J Pharm Biomed Anal. 2006;41:820-4 pubmed
    ..It was found that on MWNTs-DHP film lincomycin exhibited a well-defined oxidation peak...
  16. Berry S, Read D, Famula T, Mongini A, Döpfer D. Long-term observations on the dynamics of bovine digital dermatitis lesions on a California dairy after topical treatment with lincomycin HCl. Vet J. 2012;193:654-8 pubmed publisher
    ..cure and recurrence of the lesions of bovine digital dermatitis for 11 months after treatment with topical lincomycin HCl. The study was a clinical follow-up of 39 active bovine digital dermatitis lesions (from 29 cows)...
  17. Vučićević Prčetić K, Cservenák R, Radulovic N. Development and validation of liquid chromatography tandem mass spectrometry methods for the determination of gentamicin, lincomycin, and spectinomycin in the presence of their impurities in pharmaceutical formulations. J Pharm Biomed Anal. 2011;56:736-42 pubmed publisher
    Liquid chromatography with tandem mass spectrometry (LC/MS/MS) methods for the determination of gentamicin, lincomycin and spectinomycin in the presence of their impurities were developed and tested...
  18. McCormac A, Terry M. The nuclear genes Lhcb and HEMA1 are differentially sensitive to plastid signals and suggest distinct roles for the GUN1 and GUN5 plastid-signalling pathways during de-etiolation. Plant J. 2004;40:672-85 pubmed
    ..followed the expression of three nuclear genes, Lhcb, HEMA1 and GSA, under a variety of treatments (Norflurazon, lincomycin and a far-red light pre-treatment) leading to plastid damage in white light and in a range of genetic ..
  19. Szúnyog J, Adams E, Liekens K, Roets E, Hoogmartens J. Analysis of a formulation containing lincomycin and spectinomycin by liquid chromatography with pulsed electrochemical detection. J Pharm Biomed Anal. 2002;29:213-20 pubmed
    ..It allows the separation of a mixture of spectinomycin sulfate, lincomycin hydrochloride and their related substances...
  20. Sarvikas P, Tyystjarvi T, Tyystjärvi E. Kinetics of prolonged photoinhibition revisited: photoinhibited Photosystem II centres do not protect the active ones against loss of oxygen evolution. Photosynth Res. 2010;103:7-17 pubmed publisher
    Photoinhibition of Photosystem II (PSII) in lincomycin-treated leaves begins as a first-order reaction, but fluorescence measurements have suggested that after prolonged illumination, the number of active PSII centres stabilizes to 15-20% ..
  21. Peru K, Kuchta S, Headley J, Cessna A. Development of a hydrophilic interaction chromatography-mass spectrometry assay for spectinomycin and lincomycin in liquid hog manure supernatant and run-off from cropland. J Chromatogr A. 2006;1107:152-8 pubmed
    A specific and sensitive analytical method was developed to extract and quantify spectinomycin and lincomycin in liquid hog manure supernatant and simulated rainfall run-off from manure-treated cropland...
  22. Wang C, Ding Y, Teppen B, Boyd S, Song C, Li H. Role of interlayer hydration in lincomycin sorption by smectite clays. Environ Sci Technol. 2009;43:6171-6 pubmed
    b>Lincomycin, an antibiotic widely administered as a veterinary medicine, is frequently detected in water...
  23. Tao Y, Chen D, Yu G, Yu H, Pan Y, Wang Y, et al. Simultaneous determination of lincomycin and spectinomycin residues in animal tissues by gas chromatography-nitrogen phosphorus detection and gas chromatography-mass spectrometry with accelerated solvent extraction. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2011;28:145-54 pubmed publisher
    ..and gas chromatography-mass spectrometry (GC-MS) was developed for qualitative and quantitative measurement of lincomycin and spectinomycin residues in food animal tissues...
  24. Maksimovskiĭ I, Grinin V, Kolesnikova D. [Efficacy of treatment of chronic destructive forms of apical periodontitis using oral decontamination antibiotic therapy]. Stomatologiia (Mosk). 2003;82:16-9 pubmed
    ..Positive clinical changes were observed after lincomycin or rondomycin therapy (p = 0.017). The number of complaints was also less in the latter group (p > 0.05)...
  25. Kothadiya A. A multicentric, open label, randomised, postmarketing efficacy study comparing multidose of lincomycin hydrochloride capsule 500 mg with multidose cefpodoxime proxetil tablet 200 mg in patients with tonsillitis, sinusitis. J Indian Med Assoc. 2012;110:580-3 pubmed
    ..To study the comparative efficacy and safety of multidose treatments of lincomycin hydrochloride 500 mg capsules against cefpodoxime proxetil 200 mg tablets on its outcome in the Indian scenario ..
  26. Wu D, Gao H, Lu F, Shao L, Luo S, Xia P, et al. Evaluation of inhibition relief operations for mesophilic anaerobic bio-liquefaction of lincomycin manufacturing biowaste. Water Sci Technol. 2012;65:2200-5 pubmed publisher
    ..After evaluating the peak concentrations of volatile fatty acids (VFAs), ammonia and lincomycin in 10 d bio-liquefaction, different methods for the removal of ammonia from hydrolysate and removal of ..
  27. Sun X, McElroy A, Webb K, Sefton A, Novak C. Broiler performance and intestinal alterations when fed drug-free diets. Poult Sci. 2005;84:1294-302 pubmed
    ..assigned to 4 dietary treatments: 1) negative control (NC), basal diet; 2) positive control (PC), diet 1 + Lincomycin; 3) program 1 (PG1); diet 1 + Bio-Mos, Vegpro, MTB-100, Acid Pak 4-Way, and All-Lac XCL; 4) and program 2 (PG2), ..
  28. Yi A, Liu Z, Liu S, Hu X. Study on the interaction between palladium(II)-lincomycin chelate and erythrosine by absorption, fluorescence and resonance Rayleigh scattering spectra and its analytical applications. Luminescence. 2009;24:23-9 pubmed publisher
    In pH 5.0-5.4 HAc-NaAc buffer solution, lincomycin (Linco) reacted with Pd(II) to form 1:1 cationic chelate, which could further react with erythrosine (Ery) to form 1:1 ion-association complexes (Pd-Linco)Ery...
  29. Matsubara S, Chow W. Populations of photoinactivated photosystem II reaction centers characterized by chlorophyll a fluorescence lifetime in vivo. Proc Natl Acad Sci U S A. 2004;101:18234-9 pubmed
    ..Acceleration of photoinactivation of PSII by a pretreatment with the inhibitors/uncoupler lincomycin, DTT, or nigericin further reduced PSII Chl a fluorescence lifetimes...
  30. Egebjerg J, Garrett R. Binding sites of the antibiotics pactamycin and celesticetin on ribosomal RNAs. Biochimie. 1991;73:1145-9 pubmed
    ..Inferences are drawn concerning the mode of action of the antibiotics...
  31. Gonzalez I, Niebla A, Lemus M, Gonzalez L, Iznaga I, Perez M, et al. Ecological approach of macrolide-lincosamides-streptogramin producing actinomyces from Cuban soils. Lett Appl Microbiol. 1999;29:147-50 pubmed
    ..6%) of MLS producing strains. The other soil samples tested belonging to Guira de Melena and Bauta in Havana, Matanzas City, Topes De Collantes (Villa Clara), and Soroa Mountains (Pinar del Rio) hill reached very low percentages. ..
  32. Thongkamkoon P, Narongsak W, Kobayashi H, Pathanasophon P, Kishima M, Yamamoto K. In vitro susceptibility of Mycoplasma hyopneumoniae field isolates and occurrence of fluoroquinolone, macrolides and lincomycin resistance. J Vet Med Sci. 2013;75:1067-70 pubmed
    ..Seventy-six isolates showed resistance to enrofloxacin, whereas 2 isolates showed resistance to macrolides and lincomycin. In addition, a point mutation at A2058G was revealed by sequence analysis of 23S ribosomal RNA in both isolates...
  33. Bailey S, Thompson E, Nixon P, Horton P, Mullineaux C, Robinson C, et al. A critical role for the Var2 FtsH homologue of Arabidopsis thaliana in the photosystem II repair cycle in vivo. J Biol Chem. 2002;277:2006-11 pubmed
    ..in untreated var2-2 leaves is equivalent to that of var2-2 and wild-type leaves, which have been treated with lincomycin, an inhibitor of the photosystem II repair cycle at the level of D1 synthesis...
  34. Lumbiganon P, Surakunprapha P, Kosalaraksa P, Chaimanee P. Post operative penicillin-non-susceptible Streptococcus pneumoniae meningitis and septic shock in a child. J Med Assoc Thai. 2008;91:574-6 pubmed
    ..Penicillin-non-susceptible S. pneumoniae should be considered as one of the causes of post-operative serious infection of the face and neck in the era of increasing prevalence of penicillin-resistant S. pneumoniae. ..
  35. Fanaki N, EL NAKEEB M. A reliable two-hour Staphylococcus plate assay of rifampicin, erythromycin, lincomycin, chloramphenicol and amikacin in human sera. J Chemother. 1991;3:310-4 pubmed
    ..7%. This rapid method allowed accurate determination of RIF in the presence of erythromycin, chloramphenicol, lincomycin and amikacin...
  36. Janata J, Najmanová L, Novotna J, Hola K, Felsberg J, Spizek J. Putative lmbI and lmbH genes form a single lmbIH ORF in Streptomyces lincolnensis type strain ATCC 25466. Antonie Van Leeuwenhoek. 2001;79:277-84 pubmed
    The lincomycin-production gene cluster of the industrial overproduction strain Streptomyces lincolnensis 78-11 has been sequenced (Peschke et al...
  37. Loeza Lara P, Soto Huipe M, Baizabal Aguirre V, Ochoa Zarzosa A, Valdez Alarcón J, Cano Camacho H, et al. pBMSa1, a plasmid from a dairy cow isolate of Staphylococcus aureus, encodes a lincomycin resistance determinant and replicates by the rolling-circle mechanism. Plasmid. 2004;52:48-56 pubmed
    This work describes a novel plasmid encoding resistance to lincomycin in a staphylococcal isolate associated with mastitis infection from dairy cows...
  38. Gholamiandehkordi A, Eeckhaut V, Lanckriet A, Timbermont L, Bjerrum L, Ducatelle R, et al. Antimicrobial resistance in Clostridium perfringens isolates from broilers in Belgium. Vet Res Commun. 2009;33:1031-7 pubmed publisher
    ..Twenty-six (66%) and 24 (61%) out of the 39 tested isolates showed acquired resistance to tetracycline and lincomycin, respectively. The C...
  39. Kuchta S, Cessna A, Elliott J, Peru K, Headley J. Transport of lincomycin to surface and ground water from manure-amended cropland. J Environ Qual. 2009;38:1719-27 pubmed publisher
    ..The potential for transport of the veterinary antimicrobial lincomycin to surface waters via surface runoff and to leach to ground water was assessed by monitoring manure-amended soil,..
  40. Ando T, Fujiwara H, Kohiruimaki M, Hayashi T, Ohtsuka H, Watanabe D, et al. Peripheral blood leukocyte subpopulation of dairy cows with digital dermatitis and effect of hoof trimming with antibiotic treatment. J Vet Med Sci. 2009;71:391-5 pubmed
    ..further divided into two groups based on the treatment; the antibiotic group (8 cows) was treated with only 2% lincomycin liquid spray once daily for 3 days, and the trimmed group (10 cows) received trimming of hooves as well as ..
  41. Ogawa M, Uchiyama T, Satoh M, Ando S. Decontamination of mycoplasma-contaminated Orientia tsutsugamushi strains by repeating passages through cell cultures with antibiotics. BMC Microbiol. 2013;13:32 pubmed publisher
    ..tsutsugamushi using a mouse lung fibroblasts cell line, L-929 cell in the culture medium containing lincomycin at various concentrations and repeated passages about every seven days...
  42. Tabrizi R, Khorshidi H, Shahidi S, Gholami M, Kalbasi S, Khayati A. Use of lincomycin-impregnated demineralized freeze-dried bone allograft in the periodontal defect after third molar surgery. J Oral Maxillofac Surg. 2014;72:850-7 pubmed publisher
    The aim of the present study was to evaluate the periodontal regenerative capacity of demineralized freeze-dried bone allograft (DFDBA) alone or used with local lincomycin.
  43. Miyata K, Noguchi K, Terashima I. Cost and benefit of the repair of photodamaged photosystem II in spinach leaves: roles of acclimation to growth light. Photosynth Res. 2012;113:165-80 pubmed publisher
    ..pi)) and repair (k (rec)) by the PAM fluorometry in the presence or in the absence of lincomycin, an inhibitor of 70S protein synthesis...
  44. Llamas E, Pulido P, Rodríguez Concepción M. Interference with plastome gene expression and Clp protease activity in Arabidopsis triggers a chloroplast unfolded protein response to restore protein homeostasis. PLoS Genet. 2017;13:e1007022 pubmed publisher
    ..of Clp protease activity in mutants or wild-type plants treated with the chloroplast protein synthesis inhibitor lincomycin (LIN)...
  45. Belgio E, Johnson M, Jurić S, Ruban A. Higher plant photosystem II light-harvesting antenna, not the reaction center, determines the excited-state lifetime-both the maximum and the nonphotochemically quenched. Biophys J. 2012;102:2761-71 pubmed publisher
    ..The system was developed in Arabidopsis thaliana plants under long-term treatment with lincomycin, a chloroplast protein synthesis inhibitor...
  46. Dubos C, Willment J, Huggins D, Grant G, Campbell M. Kanamycin reveals the role played by glutamate receptors in shaping plant resource allocation. Plant J. 2005;43:348-55 pubmed
    ..These findings provide a mechanism for the conversion of amino acid and sugar signals into an appropriate response at the gene expression level, and underline the similarities in iGluR agonism between animals and plants. ..
  47. Pätsikkä E, Kairavuo M, Sersen F, Aro E, Tyystjärvi E. Excess copper predisposes photosystem II to photoinhibition in vivo by outcompeting iron and causing decrease in leaf chlorophyll. Plant Physiol. 2002;129:1359-67 pubmed
    ..3 (control), 4, or 15 microM Cu(2+). Although photoinhibition, measured in the presence of lincomycin to block concurrent recovery, is faster in leaves of Cu(2+)-treated plants than in control leaves, thylakoids ..
  48. Smirnov V, Onyshchenko O, Kiprianova O. [Gram-negative eubacteria isolated from the water, molluscs and algae of the Black Sea]. Mikrobiol Z. 2001;63:3-8 pubmed
  49. Jonas M, Morishita T, Angrick E, Jahja J. Characterization of nine Pasteurella multocida isolates from avian cholera outbreaks in Indonesia. Avian Dis. 2001;45:34-42 pubmed
    ..All of the isolates were resistant to lincomycin and sulfadiazine and were susceptible to ampicillin and trimethoprim...
  50. Rosato A, Vicarini H, Leclercq R. Inducible or constitutive expression of resistance in clinical isolates of streptococci and enterococci cross-resistant to erythromycin and lincomycin. J Antimicrob Chemother. 1999;43:559-62 pubmed
    Thirty-five of 40 clinical isolates of enterococci and streptococci cross-resistant to erythromycin and lincomycin and harbouring erm genes were inducibly resistant to these drugs, suggesting that ribosomal methylation is predominantly ..
  51. Wright A, Vesta K, Stark J, Smith W. Stevens-Johnson syndrome associated with furosemide: a case report. J Pharm Pract. 2010;23:367-70 pubmed publisher
    ..a probable association of Stevens-Johnson Syndrome (SJS) with furosemide and suspected cross-sensitivity with lincomycin and silver sulfadiazine cream...
  52. Demars R, Weinfurter J, Guex E, Lin J, Potucek Y. Lateral gene transfer in vitro in the intracellular pathogen Chlamydia trachomatis. J Bacteriol. 2007;189:991-1003 pubmed
    ..in the absence of antibiotics with an ofloxacin-resistant mutant and a second mutant that was resistant to lincomycin, trimethoprim, or rifampin. Selection for doubly resistant C...
  53. Kumano M, Tamakoshi A, Yamane K. A 32 kb nucleotide sequence from the region of the lincomycin-resistance gene (22 degrees-25 degrees) of the Bacillus subtilis chromosome and identification of the site of the lin-2 mutation. Microbiology. 1997;143 ( Pt 8):2775-82 pubmed
    A 32 kb nucleotide sequence in the region of the lincomycin-resistance gene, located from 22 degrees to 25 degrees on the Bacillus subtilis chromosome, was determined...