anisomycin

Summary

Summary: An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.

Top Publications

  1. Liu Y, Ge J, Li Q, Gu L, Guo X, Ma Z, et al. Anisomycin induces apoptosis of glucocorticoid resistant acute lymphoblastic leukemia CEM-C1 cells via activation of mitogen-activated protein kinases p38 and JNK. Neoplasma. 2013;60:101-10 pubmed publisher
    ..Here we investigated potential effect of anisomycin on GC-resistant T-ALL CEM-C1 cells and explored involved molecular mechanisms...
  2. Garcia DeLaTorre P, Rodriguez Ortiz C, Arreguin Martinez J, Cruz Castañeda P, Bermudez Rattoni F. Simultaneous but not independent anisomycin infusions in insular cortex and amygdala hinder stabilization of taste memory when updated. Learn Mem. 2009;16:514-9 pubmed publisher
    ..The following day, animals were injected with anisomycin in either the insular cortex (IC), central amygdala (CeA), basolateral amygdala (BLA), or simultaneously in IC ..
  3. Johansen C, Funding A, Otkjaer K, Kragballe K, Jensen U, Madsen M, et al. Protein expression of TNF-alpha in psoriatic skin is regulated at a posttranscriptional level by MAPK-activated protein kinase 2. J Immunol. 2006;176:1431-8 pubmed
    ..In vitro experiments demonstrated that both anisomycin and IL-1beta caused a significant activation of p38 MAPK and MK2 in cultured normal human keratinocytes...
  4. Malysheva M, Grigoryev A, Bulycheva T, Zatsepina O. Enhanced sensitivity of nucleoli in human proliferating cells to inhibition of protein synthesis with anisomycin. Bull Exp Biol Med. 2010;150:258-62 pubmed
    ..reaction of nuclei in cultured human cells from different tissues to inhibition of total protein synthesis with anisomycin - ribotoxin, which is now considered as a potential antitumor drug...
  5. Detz R, Abiri Z, le Griel R, Hiemstra H, van Maarseveen J. Enantioselective copper-catalysed propargylic substitution: synthetic scope study and application in formal total syntheses of (+)-anisomycin and (-)-cytoxazone. Chemistry. 2011;17:5921-30 pubmed publisher
    ..The versatility of the propargylic amines obtained was demonstrated by their further elaboration to formal total syntheses of the antibiotic (+)-anisomycin and the cytokine modulator (-)-cytoxazone.
  6. Piekarski D, Seto T, Zucker I. The protein synthesis inhibitor anisomycin reduces sex behavior during a critical period after testosterone treatment in male Syrian hamsters. Physiol Behav. 2012;105:215-9 pubmed publisher
    ..We administered the protein synthesis inhibitor anisomycin (Ani) to castrated male Syrian hamsters treated sc with 100 ?g T in an aqueous vehicle once weekly; this T ..
  7. Shin S, Lee J, Min B, Lee Y. The translation inhibitor anisomycin induces Elk-1-mediated transcriptional activation of egr-1 through multiple mitogen-activated protein kinase pathways. Exp Mol Med. 2006;38:677-85 pubmed
    ..b>Anisomycin (ANX), a protein synthesis inhibitor, stimulates mitogen-activated protein kinase (MAPK) pathways and thereby ..
  8. Gold P. Protein synthesis inhibition and memory: formation vs amnesia. Neurobiol Learn Mem. 2008;89:201-11 pubmed
    ..This view melds ideas of modulation of memory with those of consolidation of memory. ..
  9. Lee S, Choi J, Lee N, Lee H, Kim J, Yu N, et al. Synaptic protein degradation underlies destabilization of retrieved fear memory. Science. 2008;319:1253-6 pubmed publisher
    ..Moreover, the infusion of proteasome inhibitor into the CA1 region immediately after retrieval prevented anisomycin-induced memory impairment, as well as the extinction of fear memory...

More Information

Publications73

  1. Rodriguez Ortiz C, Garcia DeLaTorre P, Benavidez E, Ballesteros M, Bermudez Rattoni F. Intrahippocampal anisomycin infusions disrupt previously consolidated spatial memory only when memory is updated. Neurobiol Learn Mem. 2008;89:352-9 pubmed
    ..the role that updated information plays in retrieved spatial memory susceptibility to disruption, we injected anisomycin bilaterally in the dorsal hippocampus of Wistar rats...
  2. Wanisch K, Wotjak C. Time course and efficiency of protein synthesis inhibition following intracerebral and systemic anisomycin treatment. Neurobiol Learn Mem. 2008;90:485-94 pubmed publisher
    Since its discovery in the 1960s, anisomycin has been used for studying the impact of protein synthesis for manifold cerebral processes such as long-term plastic changes after learning...
  3. Cohen H, Kaplan Z, Matar M, Loewenthal U, Kozlovsky N, Zohar J. Anisomycin, a protein synthesis inhibitor, disrupts traumatic memory consolidation and attenuates posttraumatic stress response in rats. Biol Psychiatry. 2006;60:767-76 pubmed
    ..This study assessed the effects of administration of anisomycin, a protein synthesis inhibitor, after initial exposure, after exposure to a cue associated with triggering ..
  4. Suzuki A, Mukawa T, Tsukagoshi A, Frankland P, Kida S. Activation of LVGCCs and CB1 receptors required for destabilization of reactivated contextual fear memories. Learn Mem. 2008;15:426-33 pubmed publisher
    ..These experiments begin to reveal mechanisms underlying the destabilization of previously consolidated memories following reactivation and indicate the importance of activation of LVGCCs and CB1 in this process. ..
  5. Alberini C. The role of protein synthesis during the labile phases of memory: revisiting the skepticism. Neurobiol Learn Mem. 2008;89:234-46 pubmed
  6. Yang H, Choi H, Park S, Kim J, Moon Y. Macrophage inhibitory cytokine-1 (MIC-1) and subsequent urokinase-type plasminogen activator mediate cell death responses by ribotoxic anisomycin in HCT-116 colon cancer cells. Biochem Pharmacol. 2009;78:1205-13 pubmed publisher
    ..The ribotoxic stress agent anisomycin-induced MIC-1 gene expression which was involved in the ribotoxin-induced apoptotic pathway...
  7. Bebien M, Salinas S, Becamel C, Richard V, Linares L, Hipskind R. Immediate-early gene induction by the stresses anisomycin and arsenite in human osteosarcoma cells involves MAPK cascade signaling to Elk-1, CREB and SRF. Oncogene. 2003;22:1836-47 pubmed
    ..we investigated the endogenous signaling/transcription factor network driving IEG activation by arsenite and anisomycin in the human osteosarcoma cell line HOS/TE-85...
  8. Rosser E, Morton S, Ashton K, Cohen P, Hulme A. Synthetic anisomycin analogues activating the JNK/SAPK1 and p38/SAPK2 pathways. Org Biomol Chem. 2004;2:142-9 pubmed
    The synthesis of C(4)H and C(4)Me analogues of the JNK/p38 pathway activator anisomycin, based upon an aldol or Claisen construction of the C(3)-C(4) bond, has been demonstrated...
  9. Naghdi N, Majlessi N, Bozorgmehr T. The effect of intrahippocampal injection of testosterone enanthate (an androgen receptor agonist) and anisomycin (protein synthesis inhibitor) on spatial learning and memory in adult, male rats. Behav Brain Res. 2005;156:263-8 pubmed
    ..To study the mechanism of action of androgens in processes underlying learning and memory, anisomycin, a protein synthesis inhibitor was used to prevent the genomic effects of testosterone...
  10. Joiakim A, Mathieu P, Elliott A, Reiners J. Superinduction of CYP1A1 in MCF10A cultures by cycloheximide, anisomycin, and puromycin: a process independent of effects on protein translation and unrelated to suppression of aryl hydrocarbon receptor proteolysis by the proteasome. Mol Pharmacol. 2004;66:936-47 pubmed
    ..Similar results were obtained with the protein translation inhibitors anisomycin (ANS) and puromycin (PUR)...
  11. Rudy J. Is there a baby in the bathwater? Maybe: some methodological issues for the de novo protein synthesis hypothesis. Neurobiol Learn Mem. 2008;89:219-24 pubmed
    ..continues to come from studies in which amnesia is produced by broad scale protein synthesis inhibitors such as anisomycin. What is remarkable is the uncritical acceptance of the idea that because anisomycin is a protein synthesis ..
  12. Hernandez P, Sadeghian K, Kelley A. Early consolidation of instrumental learning requires protein synthesis in the nucleus accumbens. Nat Neurosci. 2002;5:1327-31 pubmed
    ..Post-trial infusions of anisomycin immediately after the first several training sessions prevented consolidation, whereas infusions delayed by 2 or ..
  13. Hansen J, Moore P, Steitz T. Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit. J Mol Biol. 2003;330:1061-75 pubmed
    Structures of anisomycin, chloramphenicol, sparsomycin, blasticidin S, and virginiamycin M bound to the large ribosomal subunit of Haloarcula marismortui have been determined at 3.0A resolution...
  14. Kjellerup R, Kragballe K, Iversen L, Johansen C. Pro-inflammatory cytokine release in keratinocytes is mediated through the MAPK signal-integrating kinases. Exp Dermatol. 2008;17:498-504 pubmed
    ..initiation factor 4E (eIF4E) are phosphorylated in a time-dependent manner in response to stimulation with anisomycin or interleukin (IL)-1beta. Both the stimuli are well-recognized activators of the p38 MAPK pathway...
  15. Sadowski R, Canal C, Gold P. Lidocaine attenuates anisomycin-induced amnesia and release of norepinephrine in the amygdala. Neurobiol Learn Mem. 2011;96:136-42 pubmed publisher
    When administered near the time of training, protein synthesis inhibitors such as anisomycin impair later memory. A common interpretation of these findings is that memory consolidation requires new protein synthesis initiated by training...
  16. Wu G, Robertson A, Liu X, Zheng P, Wilen R, Nesbitt N, et al. A lipid transfer protein gene BG-14 is differentially regulated by abiotic stress, ABA, anisomycin, and sphingosine in bromegrass (Bromus inermis). J Plant Physiol. 2004;161:449-58 pubmed
    ..both in bromegrass (Bromus inermis) cells and seedlings after exposure to abiotic stresses, abscisic acid (ABA), anisomycin, and sphingosine...
  17. Karpova A, Mikhaylova M, Thomas U, Knopfel T, Behnisch T. Involvement of protein synthesis and degradation in long-term potentiation of Schaffer collateral CA1 synapses. J Neurosci. 2006;26:4949-55 pubmed
    ..Applying anisomycin, a protein synthesis inhibitor, caused NLS-d1EGFP levels to decline; a proteasome inhibitor MG132 reversed this ..
  18. Regmi S, Rothberg K, Hubbard J, Ruben L. The RACK1 signal anchor protein from Trypanosoma brucei associates with eukaryotic elongation factor 1A: a role for translational control in cytokinesis. Mol Microbiol. 2008;70:724-45 pubmed publisher
    ..Under these conditions, cell growth became hypersensitive to the translational inhibitor anisomycin. The kinetoplasts and nuclei were misaligned in the postmitotic cells, resulting in partial cleavage furrow ..
  19. von Hertzen L, Giese K. Memory reconsolidation engages only a subset of immediate-early genes induced during consolidation. J Neurosci. 2005;25:1935-42 pubmed
    ..Such partial rather than total recapitulation may have evolved as a more economic and reliable mechanism for organisms to modify memory. ..
  20. Croons V, Martinet W, Herman A, Timmermans J, De Meyer G. The protein synthesis inhibitor anisomycin induces macrophage apoptosis in rabbit atherosclerotic plaques through p38 mitogen-activated protein kinase. J Pharmacol Exp Ther. 2009;329:856-64 pubmed publisher
    ..Therefore, in the present study, we investigated the effect of anisomycin, a translation inhibitor with a mechanism of action similar to cycloheximide, on macrophage and SMC viability...
  21. Shafer L, Slice L. Anisomycin induces COX-2 mRNA expression through p38(MAPK) and CREB independent of small GTPases in intestinal epithelial cells. Biochim Biophys Acta. 2005;1745:393-400 pubmed
    ..b>Anisomycin and sorbitol induced COX-2 expression in non-transformed, intestinal epithelial IEC-18 cells...
  22. Debiec J, LeDoux J, Nader K. Cellular and systems reconsolidation in the hippocampus. Neuron. 2002;36:527-38 pubmed
    ..Here, we show that intra-hippocampal infusions of the protein synthesis inhibitor anisomycin caused amnesia for a consolidated hippocampal-dependent contextual fear memory, but only if the memory was ..
  23. Cohen Matsliah S, Motanis H, Rosenblum K, Barkai E. A novel role for protein synthesis in long-term neuronal plasticity: maintaining reduced postburst afterhyperpolarization. J Neurosci. 2010;30:4338-42 pubmed publisher
    ..It would appear that both synaptic and intrinsic modifications and maintenance are activated jointly to enable long-lasting memories. ..
  24. Jiang Z, Belforte J, Lu Y, Yabe Y, Pickel J, Smith C, et al. eIF2alpha Phosphorylation-dependent translation in CA1 pyramidal cells impairs hippocampal memory consolidation without affecting general translation. J Neurosci. 2010;30:2582-94 pubmed publisher
    ..For instance, anisomycin interferes with protein synthesis by inhibiting peptidyl transferase or the 80S ribosomal function...
  25. Xing F, Yu Z, Liu J, Di J, Zeng S, Chen D, et al. Anisomycin inhibits the behaviors of T cells and the allogeneic skin transplantation in mice. J Immunother. 2008;31:858-70 pubmed publisher
    ..We accidentally found that a quite low dose of anisomycin was sufficient to block proliferation of T cells...
  26. Qi Z, Gold P. Intrahippocampal infusions of anisomycin produce amnesia: contribution of increased release of norepinephrine, dopamine, and acetylcholine. Learn Mem. 2009;16:308-14 pubmed publisher
    Intra-amygdala injections of anisomycin produce large increases in the release of norepinephrine (NE), dopamine (DA), and serotonin in the amygdala...
  27. You H, Woo C, Choi E, Cho S, Yoo Y, Kim J. Roles of Rac and p38 kinase in the activation of cytosolic phospholipase A2 in response to PMA. Biochem J. 2005;388:527-35 pubmed
    ..The mediatory role of p38 kinase in cPLA2 activation was further demonstrated after a treatment with anisomycin, a very effective activator of p38 kinase...
  28. Cherla R, Lee S, Mees P, Tesh V. Shiga toxin 1-induced cytokine production is mediated by MAP kinase pathways and translation initiation factor eIF4E in the macrophage-like THP-1 cell line. J Leukoc Biol. 2006;79:397-407 pubmed
    ..8- and 11-fold, respectively, within 1 h. eIF4E activation required Stx1 enzymatic activity and was mediated by anisomycin, another ribotoxic stress inducer...
  29. Sajadi A, Samaei S, Rashidy Pour A. Intra-hippocampal microinjections of anisomycin did not block glucocorticoid-induced impairment of memory retrieval in rats: an evidence for non-genomic effects of glucocorticoids. Behav Brain Res. 2006;173:158-62 pubmed
    ..was injected 30 min before retention testing with or without prior bilateral intra-hippocampal injections of anisomycin (80 or 160 microg/mul per site) as an inhibitor of protein synthesis...
  30. Lochner A, Genade S, Hattingh S, Marais E, Huisamen B, Moolman J. Comparison between ischaemic and anisomycin-induced preconditioning: role of p38 MAPK. Cardiovasc Drugs Ther. 2003;17:217-30 pubmed
    To further evaluate the significance of p38 MAPK as trigger or mediator in ischaemic preconditioning, anisomycin and SB 203580 were used to manipulate its activation status...
  31. Salinska E, Bourne R, Rose S. Reminder effects: the molecular cascade following a reminder in young chicks does not recapitulate that following training on a passive avoidance task. Eur J Neurosci. 2004;19:3042-7 pubmed
    ..initial training we examined the temporal dynamics of amnesia induced by the protein synthesis inhibitor anisomycin and the glycosylation inhibitor 2-deoxygalactose...
  32. Puighermanal E, Marsicano G, Busquets Garcia A, Lutz B, Maldonado R, Ozaita A. Cannabinoid modulation of hippocampal long-term memory is mediated by mTOR signaling. Nat Neurosci. 2009;12:1152-8 pubmed publisher
    ..In addition, non-amnesic doses of either the mTOR blocker rapamycin or the protein synthesis inhibitor anisomycin abrogated the amnesic-like effects of THC, pointing to a mechanism involving new protein synthesis...
  33. Guo X, Wu X, Ren L, Liu G, Li L. Epigenetic mechanisms of amyloid-? production in anisomycin-treated SH-SY5Y cells. Neuroscience. 2011;194:272-81 pubmed publisher
    ..Human neuroblastoma SH-SY5Y cells were treated by anisomycin, an activator of stress-related MAPKs (JNK and p38 MAPK)...
  34. Yang S, Sharrocks A. PIASxalpha differentially regulates the amplitudes of transcriptional responses following activation of the ERK and p38 MAPK pathways. Mol Cell. 2006;22:477-87 pubmed
    ..Thus, PIASxalpha acts as a key signal integrator that permits different responses from the same transcription factor, depending on the signaling pathway that is activated. ..
  35. Li J, Huang J, Li M, Zhang H, Xing B, Chen G, et al. Anisomycin induces glioma cell death via down-regulation of PP2A catalytic subunit in vitro. Acta Pharmacol Sin. 2012;33:935-40 pubmed publisher
    To examine the effects of anisomycin on glioma cells and the related mechanisms in vitro. The U251 and U87 human glioblastoma cell lines were tested. The growth of the cells was analyzed using a CCK-8 cell viability assay...
  36. Bernardi R, Lattal K, Berger S. Anisomycin disrupts a contextual memory following reactivation in a cocaine-induced locomotor activity paradigm. Behav Neurosci. 2007;121:156-63 pubmed
    ..given a single pairing of cocaine with a specific context, and the ability of the protein synthesis inhibitor anisomycin administered following a context-only memory retrieval trial to impair conditioned locomotor sensitization was ..
  37. Milekic M, Alberini C. Temporally graded requirement for protein synthesis following memory reactivation. Neuron. 2002;36:521-5 pubmed
    ..Here, we show that the requirement for protein synthesis of a reactivated memory is evident only when the memory is recent. In fact, memory vulnerability decreases as the time between the original training and the recall increases. ..
  38. Pap M, Szeberenyi J. Involvement of proteolytic activation of protein kinase R in the apoptosis of PC12 pheochromocytoma cells. Cell Mol Neurobiol. 2008;28:443-56 pubmed
    ..We found that administration of various apoptosis inducing agents and conditions (serum starvation, anisomycin, LY294002, etoposide, and cisplatin) led to the proteolytic cleavage of PKR in PC12 cells...
  39. Methippara M, Alam M, Kumar S, Bashir T, Szymusiak R, McGinty D. Administration of the protein synthesis inhibitor, anisomycin, has distinct sleep-promoting effects in lateral preoptic and perifornical hypothalamic sites in rats. Neuroscience. 2008;151:1-11 pubmed
    ..In this study, we compared the effects of local microdialytic administration of the protein synthesis inhibitor, anisomycin (ANI) into the lateral preoptic area (LPOA), a sleep promoting area vs...
  40. Soloaga A, Thomson S, Wiggin G, Rampersaud N, Dyson M, Hazzalin C, et al. MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14. EMBO J. 2003;22:2788-97 pubmed
    ..We conclude that MSKs are the major kinases for histone H3 and HMG-14 in response to mitogenic and stress stimuli in fibroblasts. ..
  41. Power A, Berlau D, McGaugh J, Steward O. Anisomycin infused into the hippocampus fails to block "reconsolidation" but impairs extinction: the role of re-exposure duration. Learn Mem. 2006;13:27-34 pubmed
    ..or retained in the shock context for 200 sec, and intrahippocampal infusions of the protein synthesis inhibitor anisomycin (75 microg/side) were administered immediately after the test...
  42. Ben Mamou C, Gamache K, Nader K. NMDA receptors are critical for unleashing consolidated auditory fear memories. Nat Neurosci. 2006;9:1237-9 pubmed
    ..These findings suggest that NMDA receptors in the amygdala are critical for transforming a memory from a fixed to a labile state. ..
  43. Konishi Y, Sato H, Tanaka T. Anisomycin superinduces annexin V mRNA expression through the ERK1/2 but not the p38 MAP kinase pathway. Biochem Biophys Res Commun. 2004;313:977-83 pubmed
    ..In this study, we utilized anisomycin, a protein synthesis inhibitor that activates MAP kinases (MAPKs), to examine the role of MAPKs in annexin V ..
  44. Fischer A, Sananbenesi F, Schrick C, Spiess J, Radulovic J. Distinct roles of hippocampal de novo protein synthesis and actin rearrangement in extinction of contextual fear. J Neurosci. 2004;24:1962-6 pubmed
    ..Intrahippocampal injections of the protein synthesis inhibitors anisomycin and puromycin, or of the actin rearrangement inhibitors cytochalasin D and latrunculin A, prevented the ..
  45. Stafford J, Lattal K. Direct comparisons of the size and persistence of anisomycin-induced consolidation and reconsolidation deficits. Learn Mem. 2009;16:494-503 pubmed publisher
    ..a context and the levels of performance in that context prior to delivery of the protein synthesis inhibitor anisomycin. We found that systemic or intrahippocampal administration of anisomycin caused a deficit in groups receiving ..
  46. Rossato J, Bevilaqua L, Medina J, Izquierdo I, Cammarota M. Retrieval induces hippocampal-dependent reconsolidation of spatial memory. Learn Mem. 2006;13:431-40 pubmed
    ..Our results suggest the existence of a hippocampal protein synthesis-dependent reconsolidation process that operates to recover or update retrieval-weakened memories from incomplete extinction. ..
  47. Darragh J, Soloaga A, Beardmore V, Wingate A, Wiggin G, Peggie M, et al. MSKs are required for the transcription of the nuclear orphan receptors Nur77, Nurr1 and Nor1 downstream of MAPK signalling. Biochem J. 2005;390:749-59 pubmed
    ..of mouse embryonic fibroblasts with PMA, EGF (epidermal growth factor), TNF (tumour necrosis factor) or anisomycin resulted in induction of the Nur77 mRNA...
  48. Lattal K, Abel T. Behavioral impairments caused by injections of the protein synthesis inhibitor anisomycin after contextual retrieval reverse with time. Proc Natl Acad Sci U S A. 2004;101:4667-72 pubmed
    ..In this article, we show that the impairments in behavior caused by the protein synthesis inhibitor anisomycin given after retrieval are temporary and are thus not likely to reflect disruptions in a protein synthesis-..
  49. Frankland P, Ding H, Takahashi E, Suzuki A, Kida S, Silva A. Stability of recent and remote contextual fear memory. Learn Mem. 2006;13:451-7 pubmed
    ..We infused the protein synthesis inhibitor, anisomycin (ANI), into either the dHPC or ACC immediately following retrieval of either a recent or remote contextual fear ..
  50. Kukushkin A, Svetlikova S, Amanzholov R, Pospelov V. Anisomycin abrogates repression of protooncogene c-fos transcription in E1A + cHa-ras-transformed cells through activation of MEK/ERK kinase cascade. J Cell Biochem. 2008;103:1005-12 pubmed
    ..Here we showed that stress-inducing agent anisomycin was able to override the c-fos repression and to induce c-fos transcription in E1A + ras transformants...
  51. Seo B, Min K, Kim S, Park J, Park W, Lee T, et al. Anisomycin treatment enhances TRAIL-mediated apoptosis in renal carcinoma cells through the down-regulation of Bcl-2, c-FLIP(L) and Mcl-1. Biochimie. 2013;95:858-65 pubmed publisher
    b>Anisomycin is known to inhibit protein synthesis and induce ribotoxic stress. In this study, we investigated whether anisomycin treatment could modulate TRAIL-mediated apoptosis in human renal carcinoma Caki cells...
  52. Vázquez Macías A, Ruíz Mendoza A, Fonseca Sánchez M, Briones Orta M, Macias Silva M. Downregulation of Ski and SnoN co-repressors by anisomycin. FEBS Lett. 2005;579:3701-6 pubmed
    ..We have found that anisomycin is able to downregulate Ski and SnoN via proteasome as TGF-beta does, but through a mechanism independent of ..
  53. Rudy J, Biedenkapp J, Moineau J, Bolding K. Anisomycin and the reconsolidation hypothesis. Learn Mem. 2006;13:1-3 pubmed
  54. Blaha G, Gürel G, Schroeder S, Moore P, Steitz T. Mutations outside the anisomycin-binding site can make ribosomes drug-resistant. J Mol Biol. 2008;379:505-19 pubmed publisher
    Eleven mutations that make Haloarcula marismortui resistant to anisomycin, an antibiotic that competes with the amino acid side chains of aminoacyl tRNAs for binding to the A-site cleft of the large ribosomal unit, have been identified in ..
  55. Robinson M, Franklin K. Effects of anisomycin on consolidation and reconsolidation of a morphine-conditioned place preference. Behav Brain Res. 2007;178:146-53 pubmed
    ..We now report that intra-cerebroventricular (ICV) anisomycin (400microg) prevents consolidation of morphine-induced place preference (CPP), but does not impair its ..
  56. Blaiss C, Janak P. Post-training, but not post-reactivation, administration of amphetamine and anisomycin modulates Pavlovian conditioned approach. Neurobiol Learn Mem. 2007;87:644-58 pubmed
    The psychostimulant, amphetamine (AMPH), and the protein synthesis inhibitor, anisomycin (ANI), have been shown to modulate the consolidation and reconsolidation of several types of learning...
  57. Ferreiro I, Joaquin M, Islam A, Gomez Lopez G, Barragan M, Lombardia L, et al. Whole genome analysis of p38 SAPK-mediated gene expression upon stress. BMC Genomics. 2010;11:144 pubmed publisher
    ..p38 SAPK activating-stimuli, namely osmostress, the cytokine TNFalpha and the protein synthesis inhibitor anisomycin. We have found that the activation kinetics of p38alpha SAPK in response to these insults is different and also ..
  58. Rodriguez Ortiz C, De La Cruz V, Gutierrez R, Bermudez Rattoni F. Protein synthesis underlies post-retrieval memory consolidation to a restricted degree only when updated information is obtained. Learn Mem. 2005;12:533-7 pubmed
    ..Our results suggest that retrieved memory can be modified as part of a mechanism for incorporating updated information into previously consolidated memory. ..
  59. Baumbauer K, Young E, Hoy K, France J, Joynes R. Intrathecal infusions of anisomycin impact the learning deficit but not the learning effect observed in spinal rats that have received instrumental training. Behav Brain Res. 2006;173:299-309 pubmed
    ..As such, we administered various doses of anisomycin intrathecally prior to training...
  60. Mawji I, Simpson C, Gronda M, Williams M, Hurren R, Henderson C, et al. A chemical screen identifies anisomycin as an anoikis sensitizer that functions by decreasing FLIP protein synthesis. Cancer Res. 2007;67:8307-15 pubmed
    ..From this chemical screen, we identified anisomycin that induced apoptosis in suspension conditions, but was not toxic to these cells grown under adherent ..