thiabendazole

Summary

Summary: 2-Substituted benzimidazole first introduced in 1962. It is active against a variety of nematodes and is the drug of choice for STRONGYLOIDIASIS. It has CENTRAL NERVOUS SYSTEM side effects and hepatototoxic potential. (From Smith and Reynard, Textbook of Pharmacology, 1992, p919)

Top Publications

  1. Safdar A, Malathum K, Rodriguez S, Husni R, Rolston K. Strongyloidiasis in patients at a comprehensive cancer center in the United States. Cancer. 2004;100:1531-6 pubmed
    ..Fourteen (74%) of 19 patients responded to thiabendazole therapy. Two patients with definite pulmonary hyperinfection syndrome developed fatal S...
  2. von Samson Himmelstjerna G, Walsh T, Donnan A, Carriere S, Jackson F, Skuce P, et al. Molecular detection of benzimidazole resistance in Haemonchus contortus using real-time PCR and pyrosequencing. Parasitology. 2009;136:349-58 pubmed publisher
    ..beta-tubulin isotype 1 sequences of 18 Haemonchus contortus isolates with varying levels of resistance to thiabendazole. The only polymorphism whose frequency was significantly increased in the resistant isolates was TTC to TAC at ..
  3. López Flores J, Fernández de Córdova M, Molina Diaz A. Simultaneous flow-injection solid-phase fluorometric determination of thiabendazole and metsulfuron methyl using photochemical derivatization. Anal Sci. 2009;25:681-6 pubmed
    ..implemented with photochemically induced fluorescence (PIF) is reported for the simultaneous determination of thiabendazole (TBZ) and metsulfuron methyl (MET)...
  4. Lemaire G, Delescluse C, Pralavorio M, Ledirac N, Lesca P, Rahmani R. The role of protein tyrosine kinases in CYP1A1 induction by omeprazole and thiabendazole in rat hepatocytes. Life Sci. 2004;74:2265-78 pubmed
    Benzimidazoles compounds like omeprazole (OME) and thiabendazole (TBZ) mediate CYP1A1 induction differently from classical aryl hydrocarbon receptor (AhR) ligands, 3-methylcholanthrene (3-MC) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)..
  5. Segarra Newnham M. Manifestations, diagnosis, and treatment of Strongyloides stercoralis infection. Ann Pharmacother. 2007;41:1992-2001 pubmed
    ..Treatment options for uncomplicated disease include thiabendazole, ivermectin, and albendazole...
  6. Zhou Q, Zhai Y, Lou J, Liu M, Pang X, Sun F. Thiabendazole inhibits ubiquinone reduction activity of mitochondrial respiratory complex II via a water molecule mediated binding feature. Protein Cell. 2011;2:531-42 pubmed publisher
    ..Crystal structure of the SQR bound with thiabendazole (TBZ) reveals a different inhibitor-binding feature at the ubiquinone binding site where a water molecule ..
  7. Bapiro T, Sayi J, Hasler J, Jande M, Rimoy G, Masselle A, et al. Artemisinin and thiabendazole are potent inhibitors of cytochrome P450 1A2 (CYP1A2) activity in humans. Eur J Clin Pharmacol. 2005;61:755-61 pubmed
    To investigate the likelihood of artemisinin and thiabendazole causing pharmacokinetic interactions involving cytochrome P450 (CYP1A2) in humans given their potent inhibitory effects on the isoform in vitro...
  8. Bisoffi Z, Buonfrate D, Angheben A, Boscolo M, Anselmi M, Marocco S, et al. Randomized clinical trial on ivermectin versus thiabendazole for the treatment of strongyloidiasis. PLoS Negl Trop Dis. 2011;5:e1254 pubmed publisher
    ..Tropical Diseases (Verona, Italy) to compare efficacy and safety of ivermectin (single dose, 200 µg/kg) and thiabendazole (two daily doses of 25 mg/Kg for two days) to cure strongyloidiasis...
  9. Chen X, Du X, Liu J, Balasubramanian M, Balasundaram D. Identification of genes encoding putative nucleoporins and transport factors in the fission yeast Schizosaccharomyces pombe: a deletion analysis. Yeast. 2004;21:495-509 pubmed
    ..identified five non-essential null mutants that were hypersensitive to the microtubule depolymerizing drug thiabendazole (TBZ) and exhibited a cut phenotype upon TBZ treatment, suggesting possible involvement in microtubule ..

More Information

Publications86

  1. Sawin K, Nurse P. Regulation of cell polarity by microtubules in fission yeast. J Cell Biol. 1998;142:457-71 pubmed
    ..synchronously form branched cells at high frequency upon treatment with the microtubule-depolymerizing drug thiabendazole (TBZ)...
  2. Inoue H, Noda A, Takama T, Ishima T, Agata K. Enhanced antifungal effect of the selective medium for the detection of Legionella species by a combination of cycloheximide, amphotericin B and thiabendazole. Biocontrol Sci. 2006;11:69-74 pubmed
    ..Consequently, it was demonstrated that the combination of cycloheximide, amphotericin B and thiabendazole was very effective in eliminating molds on agar plates, and resulted in the improved detection of Legionella...
  3. Armson A, Cunningham G, Grubb W, Mendis A. Murine strongyloidiasis: the effects of cyclosporin A and thiabendazole administered singly and in combination. Int J Parasitol. 1995;25:533-5 pubmed
    ..i., reducing the faecal larval count by 41.6 +/- 8.6%. Thiabendazole (TBZ) given orally at 5 or 10 mg kg-1 (single dose at day 4 p.i.) reduced the faecal larval counts by 57...
  4. Booher R, Beach D. Involvement of cdc13+ in mitotic control in Schizosaccharomyces pombe: possible interaction of the gene product with microtubules. EMBO J. 1988;7:2321-7 pubmed
    ..cdc13-117 mutant strains were found to be hypersensitive to the tubulin inhibitor thiabendazole. This observation suggests that the cdc13+ gene product, which is required for mitotic initiation, may ..
  5. Delescluse C, Ledirac N, Li R, Piechocki M, Hines R, Gidrol X, et al. Induction of cytochrome P450 1A1 gene expression, oxidative stress, and genotoxicity by carbaryl and thiabendazole in transfected human HepG2 and lymphoblastoid cells. Biochem Pharmacol. 2001;61:399-407 pubmed
    Carbaryl and thiabendazole, two widely used pesticides, have been shown to induce cytochrome P450 1A1 (CYP1A1) expression, but neither compound is capable of displacing [3H] 2,3,7,8-tetrachlorodibenzo-P-dioxin from its aryl hydrocarbon ..
  6. Piccirilli G, Escandar G. A novel flow-through fluorescence optosensor for the determination of thiabendazole. Anal Chim Acta. 2007;601:196-203 pubmed
    ..system combined with solid-surface fluorescence detection for the determination of the widely used fungicide thiabendazole. Nylon powder was probed as a novel solid support for building the optosensor...
  7. Piccirilli G, Escandar G. Second-order advantage with excitation-emission fluorescence spectroscopy and a flow-through optosensing device. Simultaneous determination of thiabendazole and fuberidazole in the presence of uncalibrated interferences. Analyst. 2010;135:1299-308 pubmed publisher
    ..The sensor is based on the simultaneous retention of thiabendazole and fuberidazole on C18-bonded phase placed inside a flow-cell...
  8. Piccirilli G, Escandar G. Flow injection analysis with on-line nylon powder extraction for room-temperature phosphorescence determination of thiabendazole. Anal Chim Acta. 2009;646:90-6 pubmed publisher
    ..flow-through phosphorescence optosensor was designed and characterized for the determination of the fungicide thiabendazole in water samples...
  9. Sturchler D, Schubarth P, Gualzata M, Gottstein B, Oettli A. Thiabendazole vs. albendazole in treatment of toxocariasis: a clinical trial. Ann Trop Med Parasitol. 1989;83:473-8 pubmed
    ..six to 83 years) with visceral or ocular larva migrans were randomly assigned to a five-day treatment with thiabendazole 2 x 25 mg kg-1 day-1 (15 patients) or albendazole 2 x 5 mg kg-1 day-1 (19 patients)...
  10. Lopez Garcia B, Veyrat A, Perez Paya E, González Candelas L, Marcos J. Comparison of the activity of antifungal hexapeptides and the fungicides thiabendazole and imazalil against postharvest fungal pathogens. Int J Food Microbiol. 2003;89:163-70 pubmed
    ..In addition, peptide activities were compared with that of two fungicides used for citrus fruit preservation, thiabendazole (TBZ) and imazalil (IMZ)...
  11. Schirra M, D Aquino S, Palma A, Angioni A, Cabras P. Factors affecting the synergy of thiabendazole, sodium bicarbonate, and heat to control postharvest green mold of citrus fruit. J Agric Food Chem. 2008;56:10793-8 pubmed publisher
    The efficacy of thiabendazole (TBZ) to control postharvest decay caused by Penicillium digitatum of citrus fruit can be enhanced by co-application with sodium bicarbonate (SBC) and/or heat treatment...
  12. Igual Adell R, Oltra Alcaraz C, Soler Company E, Sánchez Sánchez P, Matogo Oyana J, Rodríguez Calabuig D. Efficacy and safety of ivermectin and thiabendazole in the treatment of strongyloidiasis. Expert Opin Pharmacother. 2004;5:2615-9 pubmed
    Treatment of strongyloidiasis has been traditionally based on thiabendazole, despite its frequent gastrointestinal side effects and failure to achieve eradication of the parasite from faeces in approximately 30% of cases...
  13. Kudo N, Kubota H, Gotoh H, Ishida H, Ikadai H, Oyamada T. Efficacy of thiabendazole, mebendazole, levamisole and ivermectin against gullet worm, Gongylonema pulchrum: in vitro and in vivo studies. Vet Parasitol. 2008;151:46-52 pubmed
    In vitro and in vivo studies were conducted to evaluate the effects of thiabendazole, mebendazole, levamisole and ivermectin against Gongylonema pulchrum...
  14. Estevez M, Belenguer J, Gomez Montes S, Miralles J, Escuela A, Montoya A, et al. Indirect competitive immunoassay for the detection of fungicide Thiabendazole in whole orange samples by Surface Plasmon Resonance. Analyst. 2012;137:5659-65 pubmed publisher
    A highly sensitive and specific SPR-based competitive immunoassay for the detection of Thiabendazole (TBZ) has been developed. An indirect format where a TBZ-protein conjugate is immobilized onto gold surfaces has been selected...
  15. Deng H, Xiang B, Xie S, Zhou X. Trace determination of carbendazim and thiabendazole in drinking water by liquid chromatography and using linear modulated stochastic resonance algorithm. Arzneimittelforschung. 2007;57:717-22 pubmed publisher
    ..an attempt to determine the trace levels of two benzimidazole fungicides (carbendazim, CAS 10605-21-7 and thiabendazole, CAS 148-79-8) in drinking water samples using the newly proposed linear modulated stochastic resonance ..
  16. Wolkow T, Enoch T. Fission yeast Rad26 responds to DNA damage independently of Rad3. BMC Genet. 2003;4:6 pubmed
    ..Formation of these structures did not require other checkpoint proteins. These data demonstrate that Rad26 can respond to genotoxic insult in the absence of Rad3 and the other checkpoint Rad proteins. ..
  17. Blazkova M, Rauch P, Fukal L. Strip-based immunoassay for rapid detection of thiabendazole. Biosens Bioelectron. 2010;25:2122-8 pubmed publisher
    ..This study reports development of an immunostrip test for thiabendazole detection based on indirect competitive principle using carbon particles as a label...
  18. Sasaki Y, Saga A, Akasaka M, Yoshida K, Nishidate E, Su Y, et al. In vivo genotoxicity of ortho-phenylphenol, biphenyl, and thiabendazole detected in multiple mouse organs by the alkaline single cell gel electrophoresis assay. Mutat Res. 1997;395:189-98 pubmed
    In Japan, ortho-phenylphenol (OPP), biphenyl (BP), and thiabendazole (2-(4'-thiazolyl)benzimidazole, TBZ) are commonly used as a postharvest treatment to preserve imported citrus fruits during transport and storage...
  19. Tanaka T. Reproductive and neurobehavioural effects of thiabendazole administered to mice in the diet. Food Addit Contam. 2001;18:375-83 pubmed
    b>Thiabendazole was given in the diet to provide levels of 0 (control), 0.031, 0.125, and 0...
  20. Devereux M, McCann M, Shea D, Kelly R, Egan D, Deegan C, et al. Synthesis, antimicrobial activity and chemotherapeutic potential of inorganic derivatives of 2-(4'-thiazolyl)benzimidazole[thiabendazole]: X-ray crystal structures of [Cu(TBZH)2Cl]Cl.H2O.EtOH and TBZH2NO3 (TBZH=thiabendazole). J Inorg Biochem. 2004;98:1023-31 pubmed
    b>Thiabendazole (TBZH) reacts with iron(III) nitrate causing protonation of the ligand to yield the nitrate salt [TBZH(2)NO(3)] (1). Reaction of TBZH with copper(II) acetate results in the deprotonation of the ligand yielding [Cu(TBZ)2...
  21. Kobayashi J, Sato Y, Toma H, Takara M, Shiroma Y. Application of enzyme immunoassay for postchemotherapy evaluation of human strongyloidiasis. Diagn Microbiol Infect Dis. 1994;18:19-23 pubmed
    ..anti-Strongyloides enzyme-linked immunosorbent assay antibodies were monitored before and after treatment with thiabendazole and pyrvinium pamoate in 199 patients with chronic strongyloidiasis in Okinawa, Japan...
  22. Marcos L, Terashima A, Samalvides F, Alvarez H, Lindo F, Tello R, et al. [Thiabendazole for the control of Strongyloides stercoralis infection in a hyperendemic area in Peru]. Rev Gastroenterol Peru. 2005;25:341-8 pubmed
    ..The preferred treatment is ivermectin, and thiabendazole as a second option available in certain Peruvian institutions...
  23. Cha H, Byrom M, Mead P, Ellington A, Wallingford J, Marcotte E. Evolutionarily repurposed networks reveal the well-known antifungal drug thiabendazole to be a novel vascular disrupting agent. PLoS Biol. 2012;10:e1001379 pubmed publisher
    ..This insight led to the finding that thiabendazole, an orally available antifungal drug in clinical use for 40 years, also potently inhibits angiogenesis in ..
  24. Price R, Scott M, Giddings A, Walters D, Stierum R, Meredith C, et al. Effect of butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole on cytochrome P450 forms in cultured human hepatocytes. Xenobiotica. 2008;38:574-86 pubmed
    ..effects of four food chemicals, namely butylated hydroxytoluene (BHT), curcumin (CC), propyl gallate (PG) and thiabendazole (TB), on cytochrome P450 (CYP) forms in cultured human hepatocytes. 2...
  25. Satou T, Koga M, Koike K, Tada I, Nikaido T. Nematocidal activities of thiabendazole and ivermectin against the larvae of Strongyloides ratti and S. venezuelensis. Vet Parasitol. 2001;99:311-22 pubmed
    ..We observed the activities of ivermectin and thiabendazole against larvae and calculated larval motility and velocity...
  26. Crocetti L, Maresca A, Temperini C, Hall R, Scozzafava A, Muhlschlegel F, et al. A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases. Bioorg Med Chem Lett. 2009;19:1371-5 pubmed publisher
    A sulfonamide derivative of the antihelmintic drug thiabendazole was prepared and investigated for inhibition of the zinc enzyme carbonic anhydrase CA (EC 4.2.1.1)...
  27. Harino H, Mori Y, Yamaguchi Y, Shibata K, Senda T. Monitoring of antifouling booster biocides in water and sediment from the port of Osaka, Japan. Arch Environ Contam Toxicol. 2005;48:303-10 pubmed
    ..Concentrations of Sea-Nine 211 (4,5-dichloro-2-n-octyl-3-isothiazolone), thiabendazole (2-(4-thiazolyl)-benzimidazole), IPBC (3-iodo-2-propynyl butylcarbamate), Diuron (3,4-dichlorophenyl-N, N-..
  28. Namisato S, Motomura K, Haranaga S, Hirata T, Toyama M, Shinzato T, et al. Pulmonary strongyloidiasis in a patient receiving prednisolone therapy. Intern Med. 2004;43:731-6 pubmed
    ..stercoralis. The patient was diagnosed as having pulmonary strongyloidiasis and was treated with thiabendazole and ivermectin, in addition to antimicrobial agents; her respiratory symptoms and diarrhea improved, and S...
  29. Yoshioka N, Akiyama Y, Teranishi K. Rapid simultaneous determination of o-phenylphenol, diphenyl, thiabendazole, imazalil and its major metabolite in citrus fruits by liquid chromatography-mass spectrometry using atmospheric pressure photoionization. J Chromatogr A. 2004;1022:145-50 pubmed
    ..and rapid simultaneous analytical method of four post-harvest fungicides, o-phenylphenol (OPP), diphenyl (DP), thiabendazole (TBZ), imazalil (IMZ) and its major metabolite R14821 (IMZ-M) in citrus fruits was developed...
  30. Tang B, Wang X, Liang H, Jia B, Chen Z. Study on the supramolecular interaction of thiabendazole and beta-cyclodextrin by spectrophotometry and its analytical application. J Agric Food Chem. 2005;53:8452-9 pubmed
    The beta-cyclodextrin-thiabendazole (beta-CD-TBZ) inclusion complex was synthesized and its structure characterized by (1)H NMR and IR...
  31. Cabanas R, Abarca M, Bragulat M, Cabañes F. Comparison of methods to detect resistance of Penicillium expansum to thiabendazole. Lett Appl Microbiol. 2009;48:241-6 pubmed publisher
    ..microdilution method CLSI M38-A in determining the resistance level of some Penicillium expansum isolates to thiabendazole (TBZ). The ability of the isolates to produce patulin (PAT) and citrinin (CIT) has been also assessed...
  32. Papadopoulou E, Genitsaris S, Omirou M, Perruchon C, Stamatopoulou A, Ioannides I, et al. Bioaugmentation of thiabendazole-contaminated soils from a wastewater disposal site: Factors driving the efficacy of this strategy and the diversity of the indigenous soil bacterial community. Environ Pollut. 2018;233:16-25 pubmed publisher
    The application of the fungicide thiabendazole (TBZ) in fruit packaging plants (FPP) results in the production of effluents which are often disposed in adjacent field sites...
  33. Goossens E, Dorny P, Vercammen F, Vercruysse J. Field evaluation of the efficacy of fenbendazole in captive wild ruminants. Vet Rec. 2005;157:582-6 pubmed
    ..hatch assays of the five herds, 50 per cent inhibition of hatching (ld50) was observed at a concentration of thiabendazole below 0.1 microg/ml...
  34. Tada Y, Fujitani T, Yano N, Yuzawa K, Nagasawa A, Yoneyama M. Thiabendazole induces urinary tract toxicity in male ICR mice. Toxicology. 2001;162:1-10 pubmed
    Male ICR mice were administered thiabendazole (TBZ) in the diet at concentration of 0 (control), 0.8, 1.2 and 1.6% for 44 weeks. The mortality was 10, 6, 40 or 90% in control, 0.8, 1.2 or 1.6% TBZ group, respectively...
  35. French S, Lindo J. Severe cutaneous larva migrans in a traveler to Jamaica, West Indies. J Travel Med. 2003;10:249-50 pubmed
  36. Wang Y, Sun W, Zha S, Wang H, Zhang Y. Synthesis and Biological Evaluation of Norcantharidin Derivatives Possessing an Aromatic Amine Moiety as Antifungal Agents. Molecules. 2015;20:21464-80 pubmed publisher
    ..seven showed higher activity than did cantharidin and three exhibited more significant activity than that of thiabendazole. In particular, 3-(3'-chloro-phenyl)carbamoyl norcantharidate II-8 showed the most significant fungicidal ..
  37. Watanabe Akanuma M, Ohta T, Sasaki Y. A novel genotoxic aspect of thiabendazole as a photomutagen in bacteria and cultured human cells. Toxicol Lett. 2005;158:213-9 pubmed
    b>Thiabendazole (TBZ) is a post-harvest fungicide commonly used on imported citrus fruits. We recently found that TBZ showed photomutagenicity with UVA-irradiation in the Ames test using plate incorporation method...
  38. Calza P, Baudino S, Aigotti R, Baiocchi C, Pelizzetti E. Ion trap tandem mass spectrometric identification of thiabendazole phototransformation products on titanium dioxide. J Chromatogr A. 2003;984:59-66 pubmed
    The purpose of this study is to artificially produce degradation intermediates of thiabendazole, which could be reasonably similar to those really present in the environment...
  39. Karas P, Perruchon C, Karanasios E, Papadopoulou E, Manthou E, Sitra S, et al. Integrated biodepuration of pesticide-contaminated wastewaters from the fruit-packaging industry using biobeds: Bioaugmentation, risk assessment and optimized management. J Hazard Mater. 2016;320:635-644 pubmed publisher
    ..all pesticides with bioaugmentation maximizing their depuration performance against the persistent fungicide thiabendazole (TBZ)...
  40. Young M, Early M, Mallet C, Krol J. Application of a mixed-mode solid-phase extraction and cleanup procedure for LC/MS determination of thiabendazole and carbendazim in apple juice. J AOAC Int. 2001;84:1608-13 pubmed
    ..extraction (SPE) procedure was developed for rapid extraction and cleanup for determination of the fungicides thiabendazole and carbendazim in various fruit juices...
  41. Lorge E, Thybaud V, Aardema M, Oliver J, Wakata A, Lorenzon G, et al. SFTG international collaborative study on in vitro micronucleus test I. General conditions and overall conclusions of the study. Mutat Res. 2006;607:13-36 pubmed
    ..cytosine arabinoside), aneugens and/or polyploidy inducers (colchicine, diethylstilboestrol, griseofulvin and thiabendazole), as well as non-genotoxic compounds (mannitol and clofibrate), were tested. Four cell types were used, i.e...
  42. Rubio Flores C, Martín Díaz M, Corral de la Calle M, Arranz Sánchez D, Vidaurrázaga Díaz Arcaya C. [Cutaneous larva migrans]. An Pediatr (Barc). 2004;61:270-1 pubmed
  43. Carballo M, Hick A, Soloneski S, Larramendy M, Mudry M. Genotoxic and aneugenic properties of an imidazole derivative. J Appl Toxicol. 2006;26:293-300 pubmed
    To contribute to a more accurate characterization of the mutagenic and aneugenic effects of thiabendazole (TBZ), a widely used antiparasitic and food preservative drug, the induction of sister chromatid exchanges (SCEs) and mitotic ..
  44. Maltas E, Ozmen M. Spectrofluorometric and thermal gravimetric study on binding interaction of thiabendazole with hemoglobin on epoxy-functionalized magnetic nanoparticles. Mater Sci Eng C Mater Biol Appl. 2015;54:43-9 pubmed publisher
    The interaction of thiabendazole (Tbz) with hemoglobin (Hb) on epoxy-functionalized iron oxide nanoparticles was presented in this study...
  45. Zolezzi F, Fuss J, Uzawa S, Linn S. Characterization of a Schizosaccharomyces pombe strain deleted for a sequence homologue of the human damaged DNA binding 1 (DDB1) gene. J Biol Chem. 2002;277:41183-91 pubmed
    ..The ddb1Delta strain was sensitive to UV irradiation, X-rays, methylmethane sulfonate, and thiabendazole, and these sensitivities were compared with those of the well characterized rad13Delta, rhp51Delta, and ..
  46. García Reyes J, Ortega Barrales P, Molina Diaz A. Development of a single fluorescence-based optosensor for rapid simultaneous determination of fungicides benomyl and thiabendazole in waters and commercial formulations. J Agric Food Chem. 2004;52:2197-202 pubmed
    ..method is proposed in this work for the resolution of a binary mixture of two widely used fungicides (thiabendazole and benomyl)...
  47. Hachim K, Mortajil F, Chakib A, Ramdani B, Zaid D. [Severe anguilluliasis in a chronic haemodialysis patient]. Presse Med. 2005;34:105-6 pubmed
    ..The outcome was rapidly good following treatment with thiabendazole. Some severe forms of strongyloidiasis occurring in immunodepressed or chronic dialysed patients can be fatal ..
  48. Bentzel D, Bacon D. Comparison of various anthelmintic therapies for the treatment of Trypanoxyuris microon infection in owl monkeys (Aotus nancymae). Comp Med. 2007;57:206-9 pubmed
    ..microon by perianal tape test were treated twice (on days 0 and 14) with pyrantel pamoate, ivermectin, or thiabendazole and evaluated for eggs by daily perianal tape test throughout the entire 28-d period...
  49. de Gavelle E, de Lauzon Guillain B, Charles M, Chevrier C, Hulin M, Sirot V, et al. Chronic dietary exposure to pesticide residues and associated risk in the French ELFE cohort of pregnant women. Environ Int. 2016;92-93:533-42 pubmed publisher
    ..exposure levels under the LB scenario were, in decreasing order, imazalil, piperonyl butoxide, chlorpropham, thiabendazole, iprodione and propargite...
  50. Heukelbach J, Eisele M, Jackson A, Feldmeier H. Topical treatment of tungiasis: a randomized, controlled trial. Ann Trop Med Parasitol. 2003;97:743-9 pubmed
    ..In an attempt to fill this gap, the effects of treatment with topical ivermectin (lotion), thiabendazole (ointment and lotion), metrifonate (lotion) or placebo lotion were compared in a randomized trial...
  51. Ukimori S, Kawabata N, Shimada H, Imano R, Takahashi K, Yukawa M, et al. A double mutant between fission yeast telomerase and RecQ helicase is sensitive to thiabendazole, an anti-microtubule drug. Biosci Biotechnol Biochem. 2012;76:264-9 pubmed
    ..Both the trt1? rqh1? and the trt1? rqh1-hd double mutants were sensitive to the anti-microtubule drug thiabendazole. Moreover, the trt1? rqh1-hd double mutant displayed RPA foci on the chromosome bridge at high frequency in M ..
  52. Kotze A, Clifford S, O Grady J, Behnke J, McCarthy J. An in vitro larval motility assay to determine anthelmintic sensitivity for human hookworm and Strongyloides species. Am J Trop Med Hyg. 2004;71:608-16 pubmed
  53. Altcheh J, Nallar M, Conca M, Biancardi M, Freilij H. [Toxocariasis: clinical and laboratory features in 54 patients]. An Pediatr (Barc). 2003;58:425-31 pubmed
    ..To describe the clinical and laboratory findings in children with toxocariasis...
  54. Peralta Sastre A, Manguan Garcia C, de Luis A, Belda Iniesta C, Moreno S, Perona R, et al. Checkpoint kinase 1 modulates sensitivity to cisplatin after spindle checkpoint activation in SW620 cells. Int J Biochem Cell Biol. 2010;42:318-28 pubmed publisher
    ..These findings may be potentially very useful for the stratification of patients for treatment. ..
  55. Morishita J, Matsusaka T, Goshima G, Nakamura T, Tatebe H, Yanagida M. Bir1/Cut17 moving from chromosome to spindle upon the loss of cohesion is required for condensation, spindle elongation and repair. Genes Cells. 2001;6:743-63 pubmed
    ..Bir1/Cut17 should have roles both in mitotic and in interphase chromosome. The proper location of Ark1 requires Bir1/Cut17, and the mitotic localization of Bir1/Cut17 requires sister cohesion. ..
  56. D Aquino S, Fadda A, Barberis A, Palma A, Angioni A, Schirra M. Combined effects of potassium sorbate, hot water and thiabendazole against green mould of citrus fruit and residue levels. Food Chem. 2013;141:858-64 pubmed publisher
    ..When treatment was done at 53°C, the co-application of potassium sorbate with thiabendazole reduced thiabendazole residues in Moro and Sanguinello oranges, compared to thiabendazole treatment alone...
  57. Ribeiro L, Rodrigues Junior E, Silva M, Takiuchi A, Fontes C. [Purpura in patient with disseminated strongiloidiasis]. Rev Soc Bras Med Trop. 2005;38:255-7 pubmed
    ..We present a case of an immunosuppressed man that developed disseminated strongyloidiasis with extensive purpura. ..
  58. Ardic N. [An overview of Strongyloides stercoralis and its infections]. Mikrobiyol Bul. 2009;43:169-77 pubmed
    ..Besides, albendazole or thiabendazole may used as alternative agents in the treatment...
  59. Thomé Capuano A, Catanhede Orsini Machado de Sousa S, Aburad de Carvalhosa A, Dos Santos Pinto Júnior D. Larva migrans in the oral mucosa: report of a case. Quintessence Int. 2006;37:721-3 pubmed
    ..This article describes a case of larva migrans involving the oral mucosa in a 24-year-old woman. ..
  60. Hubert J, Kerboeuf D. A microlarval development assay for the detection of anthelmintic resistance in sheep nematodes. Vet Rec. 1992;130:442-6 pubmed
    ..Good dose-response data were obtained with thiabendazole, levamisole, pyrantel tartrate and ivermectin allowing the determination of the 50 per cent lethal ..
  61. Carvalho K, Gadelha A. Effects of three benzimidazoles on growth, general morphology and ultrastructure of Tritrichomonas foetus. FEMS Microbiol Lett. 2007;275:292-300 pubmed
    ..In order to evaluate the potential trichomonicidal activity of benzimidazoles, the effects of thiabendazole, mebendazole and albendazole were analyzed on the multiplication, general morphology and ultrastructure of T...
  62. Bustamante P, Muela S, Escalera B, Peña A. Solubility behavior and prediction for antihelmintics at several temperatures in aqueous and nonaqueous mixtures. Chem Pharm Bull (Tokyo). 2010;58:644-9 pubmed
    ..in ethanol-water and ethanol-ethyl acetate mixtures at 15-35 degrees C (mebendazole) and at 25 degrees C (thiabendazole and metronidazole). The solid phases were analyzed by differential scanning calorimerty...
  63. Fernandez M, Pico Y, Manes J. Pesticide residues in oranges from Valencia (Spain). Food Addit Contam. 2001;18:615-24 pubmed
    ..7%) samples at a mean level of 1.2 mg/kg, thiabendazole in 21 (14.0%) samples at a mean level of 0.47 mg/kg and carbendazim in 5 (3.3%) samples at a mean level of 1...
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    ..in an insect host by intra-hemocelic injection. All four antimicrobials, viz., thiabendazole, quinine, albendazole, and fumagillin, significantly reduced but did not eliminate microsporidia spore counts ..
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    ..5)(BTC)(H2O)2]·ET}n (2), (where TBZ = thiabendazole, H2CDC = trans-1,4-cyclohexanedicarboxylic acid, H2C2O4 = oxalic acid, H3BTC = 1,3,5-benzenetricarboxylic acid,..
  67. Tydén E, Skarin M, Andersson Franko M, Sjöblom M, Höglund J. Differential expression of β-tubulin isotypes in different life stages of Parascaris spp after exposure to thiabendazole. Mol Biochem Parasitol. 2016;205:22-8 pubmed publisher
    ..gene expression of both isotypes in parasacaris eggs after exposure to different concentrations of thiabendazole (TBZ) for five days at 25 °C...
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    b>Thiabendazole in the substrates incurred from spraying and premixing was translocated to the pileus, stipe, and volva of selected mushrooms...
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    A method was developed for the determination of thiabendazole (TBZ) in orange juice and rind based on matrix solid-phase dispersion (MSPD)...
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    ..Vincristine, vinblastine, paclitaxel, methyl benzimidazole-2-yl carbamate (BCM), thiabendazole, cytochalasins A, B and D and latrunculin A were added to yeast extract peptone dextrose medium containing ..
  71. Baliharová V, Skalova L, Maas R, De Vrieze G, Bull S, Fink Gremmels J. The effects of mebendazole on P4501A activity in rat hepatocytes and HepG2 cells. Comparison with tiabendazole and omeprazole. J Pharm Pharmacol. 2003;55:773-81 pubmed
    ..Thus, pharmacological and toxicological consequences of P4501A induction should be taken into account in human therapy. The structure-induction relationships and differences between in-vitro systems used are discussed. ..
  72. Roest M, Ratnavel R. Cutaneous larva migrans contracted in England: a reminder. Clin Exp Dermatol. 2001;26:389-90 pubmed
    ..We report a case of cutaneous larva migrans contracted in England. This case serves as a reminder that the lack of travel abroad should not preclude the diagnosis. We discuss clinical presentation and management of cutaneous larva migrans...
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    We report the discovery of thiabendazole as a potent inhibitor (K(i) = 0...
  74. Shikiya K, Zaha O, Niimura S, Ikema M, Nakamura H, Nakayoshi T, et al. [Long term eradication rate of mebendazole therapy for strongyloidiasis]. Kansenshogaku Zasshi. 1992;66:354-9 pubmed
    ..1) The eradication rates at 2 years after single course of MBZ therapy for 28 days and a combination therapy (thiabendazole 500 mg powder form three times daily for 5 days followed by MBZ in powder form for 9 days, repeated once) were ..
  75. Casella A, Farah M, Belfort R. Antihelminthic drugs in diffuse unilateral subacute neuroretinitis. Am J Ophthalmol. 1998;125:109-11 pubmed
    To evaluate the efficacy of ivermectin and thiabendazole in confirmed cases of diffuse unilateral subacute neuroretinitis. Two patients with diffuse unilateral subacute neuroretinitis were treated with anthelminthic drugs...
  76. Sakai K, Hirasawa Y, Hashimoto A. [A case of toxocariasis with eosinophil-rich pleural effusion]. Nihon Kokyuki Gakkai Zasshi. 2002;40:494-8 pubmed
    ..We report a rare case of toxocariasis with thoracic and pleural involvement without transient pulmonary infiltrates. ..
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    The in vitro activity of thiabendazole on Ascaris lumbricoides eggs, which were recovered from uteri of worm excreted after chemotherapeutic treatment, was studied. Four concentrations of the drug were used: 1 - 2...