famotidine

Summary

Summary: A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.

Top Publications

  1. Ohsawa T, Hirata W, Higichi S. Effects of three H2-receptor antagonists (cimetidine, famotidine, ranitidine) on serum gastrin level. Int J Clin Pharmacol Res. 2002;22:29-35 pubmed
    ..The subjects were 51 patients (cimetidine: 18 patients; famotidine: 16 patients; ranitidine: 17 patients)...
  2. Sugimoto M, Furuta T, Shirai N, Nakamura A, Kajimura M, Hishida A, et al. Comparison of an increased dosage regimen of rabeprazole versus a concomitant dosage regimen of famotidine with rabeprazole for nocturnal gastric acid inhibition in relation to cytochrome P450 2C19 genotypes. Clin Pharmacol Ther. 2005;77:302-11 pubmed
    ..of an increased dosage regimen of rabeprazole with that of a concomitant dosage regimen of rabeprazole with famotidine, relative to cytochrome P450 (CYP) 2C19 genotype status, on nocturnal acid inhibition...
  3. Shimatani T, Inoue M, Kuroiwa T, Xu J, Nakamura M, Tazuma S, et al. Lafutidine, a newly developed antiulcer drug, elevates postprandial intragastric pH and increases plasma calcitonin gene-related peptide and somatostatin concentrations in humans: comparisons with famotidine. Dig Dis Sci. 2006;51:114-20 pubmed
    ..aged 23-32 years without Helicobacter pylori infection were orally administered either 10 mg lafutidine, 20 mg famotidine, or water only (control) 30 min after a standard meal (650 kcal)...
  4. Mishra Y, Ramzan I. Interaction between famotidine and neuromuscular blockers: an in vivo study in rats. Anesth Analg. 1993;77:780-3 pubmed
    The effect of histamine 2-antagonist famotidine on neuromuscular paralysis induced with either nondepolarizing or depolarizing neuromuscular blocking drugs was examined in anesthetized and mechanically ventilated rats...
  5. Zarghi A, Shafaati A, Foroutan S, Khoddam A. Development of a rapid HPLC method for determination of famotidine in human plasma using a monolithic column. J Pharm Biomed Anal. 2005;39:677-80 pubmed
    A rapid and sensitive HPLC method using a monolithic column has been developed for quantification of famotidine in plasma...
  6. Shirai N, Furuta T, Xiao F, Kajimura M, Hanai H, Ohashi K, et al. Comparison of lansoprazole and famotidine for gastric acid inhibition during the daytime and night-time in different CYP2C19 genotype groups. Aliment Pharmacol Ther. 2002;16:837-46 pubmed
    ..The effect of famotidine is independent of this genotype. To investigate the acid inhibitory effects of lansoprazole vs...
  7. Bourdet D, Pritchard J, Thakker D. Differential substrate and inhibitory activities of ranitidine and famotidine toward human organic cation transporter 1 (hOCT1; SLC22A1), hOCT2 (SLC22A2), and hOCT3 (SLC22A3). J Pharmacol Exp Ther. 2005;315:1288-97 pubmed
    ..this study was to evaluate the substrate and inhibitory activity of the H2-receptor antagonists ranitidine and famotidine toward hOCTs and to determine the hOCT isoforms involved in the absorption and elimination of these compounds in ..
  8. Adachi K, Fujishiro H, Mihara T, Komazawa Y, Kinoshita Y. Influence of lansoprazole, famotidine, roxatidine and rebamipide administration on the urea breath test for the diagnosis of Helicobacter pylori infection. J Gastroenterol Hepatol. 2003;18:168-71 pubmed
    ..The aim of this study is to clarify the effects of lansoprazole, famotidine, roxatidine and rebamipide administration on UBT sensitivity...
  9. Hamamoto N, Hashimoto T, Adachi K, Hirakawa K, Ishihara S, Inoue H, et al. Comparative study of nizatidine and famotidine for maintenance therapy of erosive esophagitis. J Gastroenterol Hepatol. 2005;20:281-6 pubmed
    ..present multicenter, randomized controlled study was performed to investigate whether nizatidine is superior to famotidine, which does not suppress acetylcholine esterase activity, in maintenance therapy for erosive esophagitis...

More Information

Publications64

  1. Poyurovsky M, Tal V, Maayan R, Gil Ad I, Fuchs C, Weizman A. The effect of famotidine addition on olanzapine-induced weight gain in first-episode schizophrenia patients: a double-blind placebo-controlled pilot study. Eur Neuropsychopharmacol. 2004;14:332-6 pubmed
    ..In this double-blind placebo-controlled study we evaluated whether the H2 antagonist famotidine may prevent/attenuate olanzapine-induced weight gain...
  2. Ayad M, Shalaby A, Abdellatef H, Hosny M. New colorimetric methods for the determination of trazodone HCl, famotidine, and diltiazem HCl in their pharmaceutical dosage forms. Anal Bioanal Chem. 2003;376:710-4 pubmed
    Two sensitive and simple spectrophotometric methods are developed for the determination of trazodone HCl, famotidine, and diltiazem HCl in pure and pharmaceutical preparations...
  3. Ng F, Tunggal P, Chu W, Lam K, Li A, Chan K, et al. Esomeprazole compared with famotidine in the prevention of upper gastrointestinal bleeding in patients with acute coronary syndrome or myocardial infarction. Am J Gastroenterol. 2012;107:389-96 pubmed publisher
    ..The objective of this study was to compare the efficacies of esomeprazole and famotidine in preventing gastrointestinal complications...
  4. Lee K, Ng C, Brouwer K, Thakker D. Secretory transport of ranitidine and famotidine across Caco-2 cell monolayers. J Pharmacol Exp Ther. 2002;303:574-80 pubmed
    The secretory transport of the H(2)-antagonists, ranitidine and famotidine, across Caco-2 cell monolayers was found to be a saturable process...
  5. Ayad M, Shalaby A, Abdellatef H, Elsaid H. Potentiometric determination of famotidine in pharmaceutical formulations. J Pharm Biomed Anal. 2002;29:247-54 pubmed
    Two new potentiometric methods for determination of famotidine in pure form and in its pharmaceutical tablet form are developed...
  6. Ye B, Cheon J, Choi K, Kim S, Kim J, Jung H, et al. Omeprazole may be superior to famotidine in the management of iatrogenic ulcer after endoscopic mucosal resection: a prospective randomized controlled trial. Aliment Pharmacol Ther. 2006;24:837-43 pubmed
    ..To prospectively compare omeprazole and famotidine for the healing of endoscopic mucosal resection-induced ulcers and for bleeding control...
  7. Ng F, Wong S, Lam K, Chu W, Chan P, Ling Y, et al. Famotidine is inferior to pantoprazole in preventing recurrence of aspirin-related peptic ulcers or erosions. Gastroenterology. 2010;138:82-8 pubmed publisher
    ..We compared the efficacy of high-dose famotidine with that of pantoprazole in preventing recurrent symptomatic ulcers/erosions...
  8. Yamaguchi Y, Katsumi N, Tauchi M, Toki M, Nakamura K, Aoki K, et al. A prospective randomized trial of either famotidine or omeprazole for the prevention of bleeding after endoscopic mucosal resection and the healing of endoscopic mucosal resection-induced ulceration. Aliment Pharmacol Ther. 2005;21 Suppl 2:111-5 pubmed
    ..To evaluate prospectively the effectiveness of famotidine or omeprazole for ulcer management after endoscopic mucosal resection...
  9. Yamao J, Kikuchi E, Matsumoto M, Nakayama M, Ann T, Kojima H, et al. Assessing the efficacy of famotidine and rebamipide in the treatment of gastric mucosal lesions in patients receiving long-term NSAID therapy (FORCE--famotidine or rebamipide in comparison by endoscopy). J Gastroenterol. 2006;41:1178-85 pubmed
    ..In this study, we compare the effects of famotidine and rebamipide on NSAID-associated gastric mucosal lesions using upper gastrointestinal endoscopy...
  10. Ashizawa N, Hashimoto T, Miyake T, Shizuku T, Imaoka T, Kinoshita Y. Efficacy of camostat mesilate compared with famotidine for treatment of functional dyspepsia: is camostat mesilate effective?. J Gastroenterol Hepatol. 2006;21:767-71 pubmed
    ..and upper gastrointestinal endoscopy were randomized to receive camostat mesilate 200 mg three times daily or famotidine 20 mg twice daily for 4 weeks...
  11. Jaimini M, Rana A, Tanwar Y. Formulation and evaluation of famotidine floating tablets. Curr Drug Deliv. 2007;4:51-5 pubmed
    The purpose of this investigation was to prepare a gastroretentive drug delivery system of famotidine. Floating tablets of famotidine were prepared employing two different grades of methocel K100 and methocel K15M by effervescent ..
  12. Rahman N, Kashif M. Kinetic spectrophotometric determination of famotidine in commercial dosage forms. Anal Sci. 2003;19:907-11 pubmed
    A simple kinetic spectrophotometric method is described for the determination of famotidine. The method is based on the oxidation of the drug with alkaline potassium permanganate...
  13. Rahman N, Kashif M. Application of ninhydrin to spectrophotometric determination of famotidine in drug formulations. Farmaco. 2003;58:1045-50 pubmed
    A simple and fast spectrophotometric procedure has been developed for the determination of famotidine. The method is based on the interaction of ninhydrin with primary amines present in the famotidine...
  14. Tzanavaras P, Verdoukas A, Balloma T. Optimization and validation of a dissolution test for famotidine tablets using flow injection analysis. J Pharm Biomed Anal. 2006;41:437-41 pubmed
    A dissolution test for famotidine tablets was optimized and validated using flow injection analysis (FIA)...
  15. Lee K, Kayser S, Hongo R, Tseng Z, Scheinman M. Famotidine and long QT syndrome. Am J Cardiol. 2004;93:1325-7 pubmed
    ..However, the association of famotidine and acquired long QT syndrome has rarely been reported...
  16. Parshad R, Kapoor S, Gupta S, Kumar A, Chattopadhyaya T. Does famotidine enhance tumor infiltrating lymphocytes in breast cancer? Results of a randomized prospective pilot study. Acta Oncol. 2002;41:362-5 pubmed
    Thirty patients with breast cancer were prospectively randomized into case and control groups receiving 40 mg famotidine preoperatively for 10-14 days and routine premedication, respectively...
  17. Hashimoto Y, Matsunaga C, Tokuyama E, Tsuji E, Uchida T, Okada H. The quantitative prediction of bitterness-suppressing effect of sweeteners on the bitterness of famotidine by sweetness-responsive sensor. Chem Pharm Bull (Tokyo). 2007;55:739-46 pubmed
    ..prediction of the bitterness-suppressing effect of sweeteners (sucrose or sugar alcohols) on the bitterness of famotidine (or quinine sulfate as control) solutions using an artificial taste sensor...
  18. Sakurai K, Nagahara A, Inoue K, Akiyama J, Mabe K, Suzuki J, et al. Efficacy of omeprazole, famotidine, mosapride and teprenone in patients with upper gastrointestinal symptoms: an omeprazole-controlled randomized study (J-FOCUS). BMC Gastroenterol. 2012;12:42 pubmed publisher
    ..score [GOS] ? 4 on a 7-point Likert scale) were randomized to treatment with omeprazole (10 mg once daily), famotidine (10 mg twice daily), mosapride (5 mg three times daily) or teprenone (50 mg three times daily)...
  19. Mozdarani H, Nasirian B, Haeri S. In vivo gamma-rays induced initial DNA damage and the effect of famotidine in mouse leukocytes as assayed by the alkaline comet assay. J Radiat Res. 2007;48:129-34 pubmed
    ..To assess gamma ray-induced DNA damage in vivo in mouse leukocytes at various doses and the effect of famotidine, blood was collected from Balb/c male mice after irradiation with 4 Gy gamma-rays at different time intervals ..
  20. Otaka M, Jin M, Odashima M, Matsuhashi T, Wada I, Horikawa Y, et al. New strategy of therapy for functional dyspepsia using famotidine, mosapride and amitriptyline. Aliment Pharmacol Ther. 2005;21 Suppl 2:42-6 pubmed
    ..In this study, we evaluated the efficacy of H2-receptor antagonist (famotidine) and 5-HT4 receptor agonist (mosapride citrate)...
  21. Zhong L, Eisenhandler R, Yeh K. Determination of famotidine in low-volume human plasma by normal-phase liquid chromatography/tandem mass spectrometry. J Mass Spectrom. 2001;36:736-41 pubmed
    ..procedure using liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS) for the determination of famotidine in human plasma and urine is described...
  22. Wu S, Ho Y, Wu H, Chen S, Ko H. Simultaneous determination of cimetidine, famotidine, nizatidine, and ranitidine in tablets by capillary zone electrophoresis. Electrophoresis. 2001;22:2758-62 pubmed
    ..capillary zone electrophoresis (CZE) method is described for the simultaneous determination of cimetidine (CIM), famotidine (FAM), nizatidine (NIZ), and ranitidine (RAN)...
  23. Baranska M, Gumienna Kontecka E, Kozlowski H, Proniewicz L. A study on the nickel II-famotidine complexes. J Inorg Biochem. 2002;92:112-20 pubmed
    Potentiometric studies have shown that Ni(II) forms three pH-dependent complexes with famotidine (L), namely: [NiHL](3+), [NiL](2+) and [NiH(-2)L]. Two of them have been isolated from solution with a Ni/famotidine ratio of 1:1. At pH 6...
  24. Quan W, Quan F, King L, Walker P. Low-dose cyclophosphamide and continuous-infusion interleukin-2 with famotidine in previously treated metastatic melanoma or kidney cancer. Cancer Biother Radiopharm. 2008;23:108-13 pubmed publisher
    ..b>Famotidine may increase IL-2 internalization by the IL-2 receptor on T-lymphocytes...
  25. Laine L, Kivitz A, Bello A, Grahn A, Schiff M, Taha A. Double-blind randomized trials of single-tablet ibuprofen/high-dose famotidine vs. ibuprofen alone for reduction of gastric and duodenal ulcers. Am J Gastroenterol. 2012;107:379-86 pubmed publisher
    ..Ulcer Formation of HZT-501 Compared with Ibuprofen: Efficacy and Safety Studies)) to assess whether double-dose famotidine given in a single-tablet combination with ibuprofen (HZT-501) significantly reduces gastric and duodenal ulcers ..
  26. Okudaira K, Furuta T, Shirai N, Sugimoto M, Miura S. Concomitant dosing of famotidine with a triple therapy increases the cure rates of Helicobacter pylori infections in patients with the homozygous extensive metabolizer genotype of CYP2C19. Aliment Pharmacol Ther. 2005;21:491-7 pubmed
    ..To examine whether famotidine would increase the cure rates of Helicobacter pylori infection by a standard triple therapy. A total of 177 H...
  27. Helali N, Tran N, Monser L, Taverna M. Capillary zone electrophoresis method for the determination of famotidine and related impurities in pharmaceuticals. Talanta. 2008;74:694-8 pubmed publisher
    ..rapid capillary zone electrophoresis (CZE) method with UV detection has been developed for the determination of famotidine and its potential impurities in pharmaceutical formulations...
  28. See M, Birnbaum A, Schechter C, Goldenberg M, Benkov K. Double-blind, placebo-controlled trial of famotidine in children with abdominal pain and dyspepsia: global and quantitative assessment. Dig Dis Sci. 2001;46:985-92 pubmed
    ..with abdominal pain and dyspepsia, 25 such children were enrolled in a double-blind, placebo-controlled trial of famotidine. Global and quantitative pain assessments were done before and after each treatment period...
  29. Kusunoki H, Kusaka M, Kido S, Yamauchi R, Fujimura Y, Watanabe Y, et al. Comparison of the effects of omeprazole and famotidine in treatment of upper abdominal symptoms in patients with reflux esophagitis. J Gastroenterol. 2009;44:261-70 pubmed publisher
    ..Patients with reflux esophagitis received famotidine 10 mg twice daily for 2 weeks, then omeprazole 10 mg once daily for 2 weeks...
  30. Inan A, Sen M, Surgit O, Ergin M, Bozer M. Effects of the histamine H2 receptor antagonist famotidine on the healing of colonic anastomosis in rats. Clinics (Sao Paulo). 2009;64:567-70 pubmed
    ..Because histamine plays an important role in immune and inflammatory reactions, we demonstrate the effects of famotidine on the healing of colonic anastomosis in rats. Twenty-eight Sprague-Dawley rats were used in the study...
  31. Ye H, Zhang Z, Gao S, Lu Y, Wang Y. [Preparation of famotidine microemulsion and its quality evaluation]. Di Yi Jun Yi Da Xue Xue Bao. 2003;23:68-70 pubmed
    To study the preparation of famotidine microemulsion (FM) and its quality evaluation, thereby to establish the quality-control criteria for this preparation...
  32. Tunggal P, Ng F, Lam K, Chan F, Lau Y. Effect of esomeprazole versus famotidine on platelet inhibition by clopidogrel: a double-blind, randomized trial. Am Heart J. 2011;162:870-4 pubmed publisher
    ..It is unknown whether famotidine, a histamine 2 receptor antagonist, interacts with clopidogrel...
  33. Wu Y, Fassihi R. Stability of metronidazole, tetracycline HCl and famotidine alone and in combination. Int J Pharm. 2005;290:1-13 pubmed
    Metronidazole, tetracycline HCl and famotidine are commonly used for the treatment of Helicobacter pylori-associated peptic ulcer...
  34. Fujiwara Y, Higuchi K, Nebiki H, Chono S, Uno H, Kitada K, et al. Famotidine vs. omeprazole: a prospective randomized multicentre trial to determine efficacy in non-erosive gastro-oesophageal reflux disease. Aliment Pharmacol Ther. 2005;21 Suppl 2:10-8 pubmed
    ..To compare the efficacy of famotidine and omeprazole in Japanese patients with non-erosive gastro-oesophageal reflux disease by a prospective ..
  35. Seno H, Nakase H, Chiba T. Usefulness of famotidine in functional dyspepsia patient treatment: comparison among prokinetic, acid suppression and antianxiety therapies. Aliment Pharmacol Ther. 2005;21 Suppl 2:32-6 pubmed
    ..patients without Helicobacter pylori infection were randomly assigned to 15 mg/day of mosapride, 40 mg/day of famotidine, or 30 mg/day of tandospirone during an 8-week treatment...
  36. Iida H, Inamori M, Akimoto K, Mawatari H, Endo H, Nozaki Y, et al. Early effects of intravenous administrations of lansoprazole and famotidine on intragastric pH. Hepatogastroenterology. 2009;56:551-4 pubmed
    ..The aim of our study was to investigate the inhibitory effects on gastric acid secretion after single intravenous administrations of lansoprazole 30 mg and famotidine 20 mg.
  37. Sener Murato─člu G, Paskaloglu K, Arbak S, Hurdag C, Ayanoglu Dulger G. Protective effect of famotidine, omeprazole, and melatonin against acetylsalicylic acid-induced gastric damage in rats. Dig Dis Sci. 2001;46:318-30 pubmed
    It has been reported that both omeprazole and famotidine have a protective effect against gastric mucosal damage induced by acetylsalicylic acid (ASA) and other nonsteroidal anti-inflammatory drugs...
  38. Jeong H, Park C, Jun C, Lee G, Kim H, Kim H, et al. A prospective randomized trial of either famotidine or pantoprazole for the prevention of bleeding after endoscopic submucosal dissection. J Korean Med Sci. 2007;22:1055-9 pubmed
    ..patients undergoing ESD due to gastric adenoma or adenocarcinoma were randomly assigned to pantoprazole or famotidine. Both drugs were given intravenously for the first 2 days, thereafter by mouth...
  39. Bersenas A, Mathews K, Allen D, Conlon P. Effects of ranitidine, famotidine, pantoprazole, and omeprazole on intragastric pH in dogs. Am J Vet Res. 2005;66:425-31 pubmed
    ..Dogs were then treated with ranitidine (2 mg/kg, IV, q 12 h), famotidine (0...
  40. Esaki M, Aoyagi K, Matsumoto T, Kuwano Y, Shimizu M, Fujishima M. Effects of omeprazole and famotidine on fibroblast growth factor-2 during artificial gastric ulcer healing in humans. Eur J Gastroenterol Hepatol. 2002;14:365-9 pubmed
    ..This study aimed to compare the effects of omeprazole and famotidine on ulcer healing and fibroblast growth factor-2 levels in gastric ulcers induced by endoscopic mucosal resection...
  41. Matar K. Influence of famotidine on verapamil pharmacokinetics in rats. Eur J Drug Metab Pharmacokinet. 2005;30:219-22 pubmed
    The effect of famotidine (4 mg/kg, p.o.) on the kinetic profile of co-administered verapamil (20 mg/kg(-1), p.o.) was studied in the rat. Plasma verapamil levels were collected serially for 12 h and measured using sensitive HPLC method...
  42. Liu W, Xiao S, Hu P, Lu H, Cui Y, Tytgat G. A new quadruple therapy for Helicobacter pylori using tripotassium dicitrato bismuthate, furazolidone, josamycin and famotidine. Aliment Pharmacol Ther. 2000;14:1519-22 pubmed
    ..d., furazolidone 100 mg b.d., josamycin 1000 mg b.d. and famotidine 20 mg b.d. (BFJF group), or triple therapy of TDB 240 mg b.d., furazolidone 100 mg b.d...
  43. Helali N, Monser L. Stability indicating method for famotidine in pharmaceuticals using porous graphitic carbon column. J Sep Sci. 2008;31:276-82 pubmed publisher
    A simple, sensitive and rapid HPLC method was developed and validated for the simultaneous determination of famotidine (FMT) and related impurities in pharmaceuticals...
  44. Abe Y, Inamori M, Togawa J, Kikuchi T, Muramatsu K, Chiguchi G, et al. The comparative effects of single intravenous doses of omeprazole and famotidine on intragastric pH. J Gastroenterol. 2004;39:21-5 pubmed
    ..the inhibitory effects on gastric acid secretion after single intravenous administrations of omeprazole 20mg and famotidine 20 mg...
  45. Murakami K, Okimoto T, Kodama M, Tanahashi J, Mizukami K, Shuto M, et al. Comparison of the efficacy of irsogladine maleate and famotidine for the healing of gastric ulcers after Helicobacter pylori eradication therapy: a randomized, controlled, prospective study. Scand J Gastroenterol. 2011;46:287-92 pubmed publisher
    ..pylori eradication therapy. We therefore compared the efficacy of irsogladine with famotidine as appropriate treatments for ulcers after eradication therapy. Gastric ulcer patients with H...
  46. Ahmadi A, Ebrahimzadeh M, Ahmad Ashrafi S, Karami M, Mahdavi M, Saravi S. Hepatoprotective, antinociceptive and antioxidant activities of cimetidine, ranitidine and famotidine as histamine H2 receptor antagonists. Fundam Clin Pharmacol. 2011;25:72-9 pubmed publisher
    ..The hepatoprotective effects of cimetidine, ranitidine and famotidine against hepatotoxicity induced by carbon tetrachloride (CCl(4) ) were determined by measuring the levels of ..
  47. Amin M, Iqbal M, Hughes R, Khan S, Reynolds P, Enne V, et al. Mechanochemical synthesis and in vitro anti-Helicobacter pylori and uresase inhibitory activities of novel zinc(II)-famotidine complex. J Enzyme Inhib Med Chem. 2010;25:383-90 pubmed publisher
    The mechanochemical synthesis and characterization of a zinc complex with famotidine is described. The complex was characterized by microanalysis and a number of spectroscopic techniques. The complex was of M:L dihydrate type...
  48. Xin Y, Dai N, Zhao L, Wang J, Si J. The effect of famotidine on gastroesophageal and duodeno-gastro-esophageal refluxes in critically ill patients. World J Gastroenterol. 2003;9:356-8 pubmed
    To investigate the effect of famotidine on gastroesophageal reflux (GER) and duodeno-gastro-esophageal reflux (DGER) and to explore it's possible mechanisms. To identify the relevant factors of the reflux...
  49. Walash M, El Brashy A, el Enany N, Kamel M. Spectrofluorimetric determination of famotidine in pharmaceutical preparations and biological fluids. Application to stability studies. J Fluoresc. 2009;19:333-44 pubmed publisher
    ..economic, selective, and stability indicating spectrofluorimetric method was developed for the determination of famotidine (FMT); is based on its reaction with 9, 10-phenanthraquinone in alkaline medium to give a highly fluorescent ..
  50. Fahmy R, Kassem M. Enhancement of famotidine dissolution rate through liquisolid tablets formulation: in vitro and in vivo evaluation. Eur J Pharm Biopharm. 2008;69:993-1003 pubmed publisher
    Although famotidine was reported to be 7.5 and 20 times more potent than ranitidine and cimetidine, respectively, its oral bioavailability is low and variable; due mainly to its poor aqueous solubility...
  51. Khatal L, Kamble A, Mahadik M, Dhaneshwar S. Validated HPTLC method for simultaneous quantitation of paracetamol, diclofenac potassium, and famotidine in tablet formulation. J AOAC Int. 2010;93:765-70 pubmed
    ..simple, selective, precise, and accurate HPTLC method of analysis for paracetamol, diclofenac potassium, and famotidine both as a bulk drug and in tablet formulation was developed and validated...
  52. Nishino M, Sugimoto M, Kodaira C, Yamade M, Uotani T, Shirai N, et al. Preventive effects of lansoprazole and famotidine on gastric mucosal injury induced by low-dose aspirin in Helicobacter pylori-negative healthy volunteers. J Clin Pharmacol. 2011;51:1079-86 pubmed publisher
    The preventive effects of lansoprazole and famotidine on low-dose aspirin-induced gastric mucosal injury in relation to gastric acidity were compared in healthy Japanese volunteers...
  53. Luyendyk J, Lehman McKeeman L, Nelson D, Bhaskaran V, Reilly T, Car B, et al. Unique gene expression and hepatocellular injury in the lipopolysaccharide-ranitidine drug idiosyncrasy rat model: comparison with famotidine. Toxicol Sci. 2006;90:569-85 pubmed
    Rats cotreated with lipopolysaccharide (LPS) and ranitidine (RAN) but not LPS and famotidine (FAM) develop hepatocellular injury in an animal model of idiosyncratic drug reactions...
  54. Harada T, Narazaki R, Nagira S, Ohwaki T, Aoki S, Iwamoto K. Evaluation of the disintegration properties of commercial famotidine 20 mg orally disintegrating tablets using a simple new test and human sensory test. Chem Pharm Bull (Tokyo). 2006;54:1072-5 pubmed
    ..Eight types of commercial famotidine 20 mg orally disintegrating tablets with different physical properties (formulation, manufacturing method, ..
  55. Tomita T, Kim Y, Yamasaki T, Okugawa T, Kondo T, Toyoshima F, et al. Prospective randomized controlled trial to compare the effects of omeprazole and famotidine in preventing delayed bleeding and promoting ulcer healing after endoscopic submucosal dissection. J Gastroenterol Hepatol. 2012;27:1441-6 pubmed publisher
    ..We prospectively compared the effects of omeprazole and famotidine in preventing delayed bleeding and promoting artificial ulcer healing after ESD...