Summary: A pyrazole derivative and selective CYCLOOXYGENASE 2 INHIBITOR that is used to treat symptoms associated with RHEUMATOID ARTHRITIS; OSTEOARTHRITIS and JUVENILE ARTHRITIS, as well as the management of ACUTE PAIN.

Top Publications

  1. Hsu A, Ching T, Wang D, Song X, Rangnekar V, Chen C. The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2. J Biol Chem. 2000;275:11397-403 pubmed
    This study investigates the apoptotic activity of the cyclooxygenase-2 (COX-2) inhibitor celecoxib in prostate carcinoma cells. COX-2 is constitutively expressed in androgen-responsive LNCaP and androgen-nonresponsive PC-3 cells...
  2. Fidahić M, Jelicic Kadic A, Radic M, Puljak L. Celecoxib for rheumatoid arthritis. Cochrane Database Syst Rev. 2017;6:CD012095 pubmed publisher
    ..b>Celecoxib is a selective non-steroidal anti-inflammatory drug (NSAID) used for treatment of people with rheumatoid ..
  3. Pramanik R, Agarwala S, Gupta Y, Thulkar S, Vishnubhatla S, Batra A, et al. Metronomic Chemotherapy vs Best Supportive Care in Progressive Pediatric Solid Malignant Tumors: A Randomized Clinical Trial. JAMA Oncol. 2017;3:1222-1227 pubmed publisher
    ..One arm received a 4-drug oral metronomic regimen of daily celecoxib and thalidomide with alternating periods of etoposide and cyclophosphamide, whereas the other arm received ..
  4. El Gowelli H, Ibrahim K, El Yazbi A, El Mas M. Role of NADPHox/Rho-kinase signaling in the cyclosporine-NSAIDs interactions on blood pressure and baroreflexes in female rats. Life Sci. 2017;185:15-22 pubmed publisher
    ..Female rats were treated for 10days with CSA (25mg/kg/day), diclofenac (DIC, COX-1/COX-2 inhibitor, 1mg/kg/day), celecoxib (COX-2 inhibitor, 10mg/kg/day), or their combinations...
  5. Klatka J, Grywalska E, Hymos A, Guz M, Polberg K, Rolinski J, et al. Cyclooxygenase-2 Inhibition Enhances Proliferation of NKT Cells Derived from Patients with Laryngeal Cancer. Anticancer Res. 2017;37:4059-4066 pubmed
    The aim of this study was to analyze whether inhibition of cyclooxygenase-2 by celecoxib and the subsequent enhancement in the proliferation of natural killer T (NKT) cells could play a role in dendritic cell (DC)-based laryngeal cancer (..
  6. . The NIH Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT). J Pain Palliat Care Pharmacother. 2008;22:39-43 pubmed
    ..Participants taking the positive control, celecoxib, experienced statistically significant pain relief versus placebo, about 70% of those taking celecoxib had a 20% ..
  7. von Haehling S, Stepney R, Anker S. Advances in understanding and treating cardiac cachexia: highlights from the 5th Cachexia Conference. Int J Cardiol. 2010;144:347-9 pubmed publisher
    ..myostatin decoy receptor ActRIIB-Fc, the fast skeletal muscle troponin activating substance CK-2017357, the anti-catabolic/anabolic transforming agent MT-102, the anti-inflammatory agent celecoxib, and testosterone supplementation.
  8. Ohkura K, Tatematsu Y, Kawaguchi Y, Uto Y, Hori H. Interactive Analysis of TX-1123 with Cyclo-oxygenase: Design of COX2 Selective TX Analogs. Anticancer Res. 2017;37:3849-3854 pubmed
    ..The TX-1123-binding pocket of COX2 differs from that of the COX2-selective celecoxib-binding pocket. TX-1123 exhibited a different COX2-interactive mechanism from that of celecoxib.
  9. Jain S, Ghanghas P, Rana C, Sanyal S. Role of GSK-3? in Regulation of Canonical Wnt/?-catenin Signaling and PI3-K/Akt Oncogenic Pathway in Colon Cancer. Cancer Invest. 2017;35:473-483 pubmed publisher
    ..b>Celecoxib and etoricoxib, the two cyclooxygenase-2 (COX-2) selective NSAIDs, and Diclofenac, a preferential COX-2 ..

More Information


  1. de Souza C, Kurauti M, Silva F, de Morais H, Curi R, Hirabara S, et al. Celecoxib and Ibuprofen Restore the ATP Content and the Gluconeogenesis Activity in the Liver of Walker-256 Tumor-Bearing Rats. Cell Physiol Biochem. 2015;36:1659-69 pubmed
    The main purpose of this study was to investigate the effects of celecoxib and ibuprofen, both non-steroidal anti-inflammatory drugs (NSAIDs), on the decreased gluconeogenesis observed in liver of Walker-256 tumor-bearing rats...
  2. Ogawa F, Amano H, Eshima K, Ito Y, Matsui Y, Hosono K, et al. Prostanoid induces premetastatic niche in regional lymph nodes. J Clin Invest. 2014;124:4882-94 pubmed publisher
  3. Rosas C, Sinning M, Ferreira A, Fuenzalida M, Lemus D. Celecoxib decreases growth and angiogenesis and promotes apoptosis in a tumor cell line resistant to chemotherapy. Biol Res. 2014;47:27 pubmed publisher
    During the last few years it has been shown in several laboratories that Celecoxib (Cx), a non-steroidal anti-inflammatory agent (NSAID) normally used for pain and arthritis, mediates antitumor and antiangiogenic effects...
  4. Mosaad S, Zaitone S, Ibrahim A, El Baz A, Abo Elmatty D, Moustafa Y. Celecoxib aggravates cardiac apoptosis in L-NAME-induced pressure overload model in rats: Immunohistochemical determination of cardiac caspase-3, Mcl-1, Bax and Bcl-2. Chem Biol Interact. 2017;272:92-106 pubmed publisher
    The mechanism of celecoxib cardiovascular adverse events was earlier investigated; yet in-depth investigations are needed to assess the involvement of its pro-apoptotic effect throughout this process...
  5. . Results of a follow-up study to the randomized Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT). Alzheimers Dement. 2013;9:714-23 pubmed publisher
    ..Prevention Trial Follow-up Study (ADAPT-FS) was designed to evaluate the efficacy of naproxen and celecoxib for the primary prevention of Alzheimer's disease (AD) several years after cessation of treatment in ADAPT...
  6. Cimbollek S, Quiralte J, Avila R. COX-2 inhibitors in patients with sensitivity to nonselective NSAIDs. N Engl J Med. 2009;361:2197-8 pubmed publisher
  7. Reginster J, Dudler J, Blicharski T, Pavelka K. Pharmaceutical-grade Chondroitin sulfate is as effective as celecoxib and superior to placebo in symptomatic knee osteoarthritis: the ChONdroitin versus CElecoxib versus Placebo Trial (CONCEPT). Ann Rheum Dis. 2017;76:1537-1543 pubmed publisher
    ..A prospective, randomised, 6-month, 3-arm, double-blind, double-dummy, placebo and celecoxib (200?mg/day)-controlled trial assessing changes in pain on a Visual Analogue Scale (VAS) and in the Lequesne ..
  8. Tang J, Fan J, Yao Y, Cai W, Yin G, Zhou W. Application of a buprenorphine transdermal patch for the perioperative analgesia in patients who underwent simple lumbar discectomy. Medicine (Baltimore). 2017;96:e6844 pubmed publisher
    ..In total, 96 patients were randomly divided into parecoxib intravenous injection (Group A), oral celecoxib (Group B), and buprenorphine transdermal patch groups (Group?C)...
  9. Meinert C, McCaffrey L, Breitner J. Alzheimer's Disease Anti-inflammatory Prevention Trial: design, methods, and baseline results. Alzheimers Dement. 2009;5:93-104 pubmed publisher
    ..Persons were randomly assigned to 200 mg b.i.d. celecoxib (Celebrex, Pfizer), 220 mg b.i.d. naproxen sodium (Aleve, Bayer), or placebo. The primary outcome measure was AD...
  10. Antman E. Evaluating the Cardiovascular Safety of Nonsteroidal Anti-Inflammatory Drugs. Circulation. 2017;135:2062-2072 pubmed publisher
    ..On the basis of phase 4 RCTs of NSAIDs to date, it appears that a comparatively low dose of celecoxib administered to low-risk subjects is associated with approximately the same cardiovascular risk as NSAIDs with ..
  11. Wang R, Tian S, Yang X, Liu J, Wang Y, Sun K. Celecoxib-induced inhibition of neurogenesis in fetal frontal cortex is attenuated by curcumin via Wnt/?-catenin pathway. Life Sci. 2017;185:95-102 pubmed publisher
    b>Celecoxib is widely used in pregnant women but its influence on fetal brain neurogenesis is largely unknown...
  12. Zhou S, Yang S, Huang G. Design, synthesis and bioactivities of Celecoxib analogues or derivatives. Bioorg Med Chem. 2017;25:4887-4893 pubmed publisher
    A series of Celecoxib analogues or derivatives were designed and synthesized, and their biological activities were studied...
  13. Kosinski M, Zhao S, Dedhiya S, Osterhaus J, Ware J. Determining minimally important changes in generic and disease-specific health-related quality of life questionnaires in clinical trials of rheumatoid arthritis. Arthritis Rheum. 2000;43:1478-87 pubmed
    ..Based on these results, minimally important changes in the SF-36 scales and HAQ disability scores were determined, which will be useful in interpreting HQL results in clinical trials. ..
  14. Chang C, Lee W, Hsieh H, Chuang C, Huang H, Lee F, et al. Selective cyclooxygenase inhibition by SC-560 improves hepatopulmonary syndrome in cirrhotic rats. PLoS ONE. 2017;12:e0179809 pubmed publisher
    ..to receive non-selective COX inhibitor (indomethacin), selective COX-1 inhibitor (SC-560), or COX-2 inhibitor (celecoxib) for 14 days...
  15. Ambadapadi S, Wang P, Palii S, James M. Celecoxib affects estrogen sulfonation catalyzed by several human hepatic sulfotransferases, but does not stimulate 17-sulfonation in rat liver. J Steroid Biochem Mol Biol. 2017;172:46-54 pubmed publisher
    b>Celecoxib is known to alter the preferred position of SULT2A1-catalyzed sulfonation of 17?-estradiol (17?-E2) and other estrogens from the 3- to the 17-position...
  16. da Costa R, Araujo R, Santos J, Fernandes M, Neto T, Sousa H, et al. Regulation of miRNA-146a and miRNA-150 Levels by Celecoxib in Premalignant Lesions of K14-HPV16 Mice. Anticancer Res. 2017;37:2913-2918 pubmed
    ..We studied the effects of celecoxib on the expression of these two miRNAs in HPV16-induced lesions...
  17. Lebedev A, Jiao J, Lee J, Yang F, Allison N, Herschman H, et al. Radiochemistry on electrodes: Synthesis of an 18F-labelled and in vivo stable COX-2 inhibitor. PLoS ONE. 2017;12:e0176606 pubmed publisher
    ..In vivo metabolism data demonstrated that > 95% of the injected radioactivity remains in the form of the parent molecule 1 hour after injection. ..
  18. Qian M, Qian D, Jing H, Li Y, Ma C, Zhou Y. Combined cetuximab and celecoxib treatment exhibits a synergistic anticancer effect on human oral squamous cell carcinoma in vitro and in vivo. Oncol Rep. 2014;32:1681-8 pubmed
    ..receptor (EGFR) pathway inhibition achieved by combining cetuximab (CET), an anti-EGFR monoclonal antibody, and celecoxib (CXB), a cyclooxygenase-2 (COX-2) inhibitor, in oral squamous cell carcinoma (OSCC) in vitro and in vivo...
  19. . Follow-up evaluation of cognitive function in the randomized Alzheimer's Disease Anti-inflammatory Prevention Trial and its Follow-up Study. Alzheimers Dement. 2015;11:216-25.e1 pubmed publisher
    ..Anti-Inflammatory Prevention Trial (ADAPT) and Follow-up Study (ADAPT-FS) examined effects of naproxen and celecoxib on cognition in the elderly. We report here results describing trajectories of cognitive evaluation test scores...
  20. Sostres C, Gargallo C, Lanas A. Nonsteroidal anti-inflammatory drugs and upper and lower gastrointestinal mucosal damage. Arthritis Res Ther. 2013;15 Suppl 3:S3 pubmed publisher
    ..Overall, mortality due to these complications has also decreased, but the in-hospital case fatality for upper and lower GI complication events has remained constant despite the new therapeutic and prevention strategies. ..
  21. Brandão R, Veeck J, Van de Vijver K, Lindsey P, de Vries B, Van Elssen C, et al. A randomised controlled phase II trial of pre-operative celecoxib treatment reveals anti-tumour transcriptional response in primary breast cancer. Breast Cancer Res. 2013;15:R29 pubmed publisher
    ..identify transcriptional changes in breast cancer tissues of patients treated with the selective COX-2 inhibitor celecoxib. In a single-centre double-blind phase II study, thirty-seven breast cancer patients were randomised to receive ..
  22. Patil V, Noronha V, Krishna V, Joshi A, Prabhash K. Oral metronomic chemotherapy in recurrent, metastatic and locally advanced head and neck cancers. Clin Oncol (R Coll Radiol). 2013;25:388 pubmed publisher
  23. Garner S, Fidan D, Frankish R, Judd M, Shea B, Towheed T, et al. WITHDRAWN: Celecoxib for rheumatoid arthritis. Cochrane Database Syst Rev. 2017;6:CD003831 pubmed publisher
    ..The NSAIDs known as the selective Cox II inhibitors, of which celecoxib is a member, were developed in order to reduce the GI toxicity, but are more expensive.
  24. Chen R, Li F, Xie Q, Xue J, Lai L, Liu S, et al. Membranous nephropathy in a patient with ankylosing spondylitis: A case report. Medicine (Baltimore). 2017;96:e8201 pubmed publisher
    ..This article reports a case of coexistence of AS and MN, to provide the exact relationship of these 2 entities and recognized some causes of renal involvement in AS...
  25. Reagan K, O Sullivan D, Gannon R, Steinberg A. Decreasing postoperative narcotics in reconstructive pelvic surgery: a randomized controlled trial. Am J Obstet Gynecol. 2017;217:325.e1-325.e10 pubmed publisher
    ..Multimodal pain regimen included preoperative and postoperative celecoxib, gabapentin, intraoperative and postoperative intravenous and oral acetaminophen and ibuprofen, and narcotics as ..
  26. Edelman M, Wang X, Hodgson L, Cheney R, Baggstrom M, Thomas S, et al. Phase III Randomized, Placebo-Controlled, Double-Blind Trial of Celecoxib in Addition to Standard Chemotherapy for Advanced Non-Small-Cell Lung Cancer With Cyclooxygenase-2 Overexpression: CALGB 30801 (Alliance). J Clin Oncol. 2017;35:2184-2192 pubmed publisher
    ..In Cancer and Leukemia Group B (CALGB) 30203, we found that the selective COX-2 inhibitor celecoxib in addition to chemotherapy in advanced NSCLC improved progression-free and overall survival in patients with ..
  27. Zhao Y, Wang H, Yin J, Sun Y, Wang Y, Liang J, et al. The Analgesic Effects of Celecoxib on the Formalin-induced Short- and Long-term Inflammatory Pain. Pain Physician. 2017;20:E575-E584 pubmed
    The non-steroidal anti-inflammatory drug celecoxib has long been used for reducing pain, in spite of moderate gastrointestinal side effects...
  28. Puljak L, Marin A, Vrdoljak D, Markotic F, Utrobicic A, Tugwell P. Celecoxib for osteoarthritis. Cochrane Database Syst Rev. 2017;5:CD009865 pubmed publisher
    ..There is currently no consensus on the best treatment to improve OA symptoms. Celecoxib is a selective non-steroidal anti-inflammatory drug (NSAID)...
  29. Brizzolara A, Benelli R, Venè R, Barboro P, Poggi A, Tosetti F, et al. The ErbB family and androgen receptor signaling are targets of Celecoxib in prostate cancer. Cancer Lett. 2017;400:9-17 pubmed publisher
    ..The purpose of this work was to determine the ability of the COX-2 inhibitor Celecoxib to modulate the EGFR-AR signaling pathway in androgen-dependent PCa cells and to provide a rationale for its ..
  30. Saber Samandari S, Saber Samandari S. Biocompatible nanocomposite scaffolds based on copolymer-grafted chitosan for bone tissue engineering with drug delivery capability. Mater Sci Eng C Mater Biol Appl. 2017;75:721-732 pubmed publisher
    ..Finally, celecoxib as a model drug was efficiently loaded into the prepared scaffolds because of the large specific surface area...
  31. Bannuru R, Schmid C, Kent D, Vaysbrot E, Wong J, McAlindon T. Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis. Ann Intern Med. 2015;162:46-54 pubmed publisher
    ..of adults with knee OA comparing 2 or more of the following: acetaminophen, diclofenac, ibuprofen, naproxen, celecoxib, intra-articular (IA) corticosteroids, IA hyaluronic acid, oral placebo, and IA placebo...
  32. Kopp K, Dabelsteen S, Krejsgaard T, Eriksen K, Geisler C, Becker J, et al. COX-2 is a novel target in therapy of mycosis fungoides. Leukemia. 2010;24:2127-9 pubmed publisher
  33. McAdam B, Catella Lawson F, Mardini I, Kapoor S, Lawson J, Fitzgerald G. Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2. Proc Natl Acad Sci U S A. 1999;96:272-7 pubmed
    ..selectivity of tolerated doses of an inhibitor of the inducible COX-2 in humans, we examined the effects of celecoxib on indices of COX-1-dependent platelet thromboxane (Tx) A2 and on systemic biosynthesis of prostacyclin in vivo...
  34. Valverde A, Peñarando J, Cañas A, Lopez Sanchez L, Conde F, Guil Luna S, et al. The addition of celecoxib improves the antitumor effect of cetuximab in colorectal cancer: role of EGFR-RAS-FOXM1-?- catenin signaling axis. Oncotarget. 2017;8:21754-21769 pubmed publisher
    Here we showed that the addition of the COX-2 inhibitor celecoxib improved the antitumor efficacy in colorectal cancer (CRC) of the monoclonal anti-EGFR antibody cetuximab...
  35. Wang G, Li J, Zhang L, Huang S, Zhao X, Zhao X. Celecoxib induced apoptosis against different breast cancer cell lines by down-regulated NF-?B pathway. Biochem Biophys Res Commun. 2017;490:969-976 pubmed publisher
    ..Here, we studied the effect of Celecoxib, a COX-2 inhibitor on two molecular breast cancer subtypes-MDA-MB-231 and SK-BR-3...
  36. Sun J, Liu N, Zhuang H, Zhao L, Yuan Z, Wang P. Celecoxib-erlotinib combination treatment enhances radiosensitivity in A549 human lung cancer cell. Cancer Biomark. 2017;19:45-50 pubmed publisher
    ..Radiosensitivity by blocking the epidermal growth factor receptor and cyclooxygenase-2 pathways with erlotinib and celecoxib in A549 human lung cancer cell was investigated...
  37. Moreno Borque R, Matito A, Alvarez Twose I, Morgado J, Sánchez Muñoz L, Orfao A, et al. Response to celecoxib in a patient with indolent systemic mastocytosis presenting with intractable diarrhea. Ann Allergy Asthma Immunol. 2015;115:456-7 pubmed publisher
  38. Moore A, Makinson G, Li C. Patient-level pooled analysis of adjudicated gastrointestinal outcomes in celecoxib clinical trials: meta-analysis of 51,000 patients enrolled in 52 randomized trials. Arthritis Res Ther. 2013;15:R6 pubmed publisher
    Although the safety of celecoxib has been investigated, limited data are available on complications affecting the entire (upper and lower) gastrointestinal (GI) tract, with no patient-level pooled analyses of upper and lower GI outcomes ..
  39. Eccleston C, Cooper T, Fisher E, Anderson B, Wilkinson N. Non-steroidal anti-inflammatory drugs (NSAIDs) for chronic non-cancer pain in children and adolescents. Cochrane Database Syst Rev. 2017;8:CD012537 pubmed publisher
    ..30% or greater, showing no statistically significant difference in pain scores between meloxicam and naproxen, celecoxib and naproxen, or rofecoxib and naproxen (P > 0.05) (low-quality evidence)...
  40. Zhou F, Du Y, Huang W, Shan J, Xu G. The efficacy and safety of early initiation of preoperative analgesia with celecoxib in patients underwent arthroscopic knee surgery: A randomized, controlled study. Medicine (Baltimore). 2017;96:e8234 pubmed publisher
    This study aimed to investigate the efficacy and safety of celecoxib 24?hours preoperative, 1?hour preoperative, and 4?hours postoperative administration in patients with arthroscopic knee surgery (AKS)...