Summary: Immunologic adjuvant and sensitizing agent.

Top Publications

  1. Man M, Hatano Y, Lee S, Man M, Chang S, Feingold K, et al. Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges. J Invest Dermatol. 2008;128:79-86 pubmed
    ..Here, 9-10 challenges with oxazolone (Ox) to hairless mice also produced a chronic Th2-like HR...
  2. Wang A, Fernando M, Leung G, Phan V, Smyth D, McKay D. Exacerbation of oxazolone colitis by infection with the helminth Hymenolepis diminuta: involvement of IL-5 and eosinophils. Am J Pathol. 2010;177:2850-9 pubmed publisher
    Substantial data show that infection with helminth parasites ameliorates colitis; however, oxazolone-induced colitis is exaggerated in mice infected with the tapeworm, Hymenolepis diminuta...
  3. Hatano Y, Man M, Uchida Y, Crumrine D, Mauro T, Feingold K, et al. Murine atopic dermatitis responds to peroxisome proliferator-activated receptors alpha and beta/delta (but not gamma) and liver X receptor activators. J Allergy Clin Immunol. 2010;125:160-9.e1-5 pubmed publisher
    ..We evaluated the efficacy of PPAR/LXR activation in a hapten (oxazolone [Ox])-induced AD-like model (Ox-AD) in hairless mice...
  4. Mori H, Yamanaka K, Matsuo K, Kurokawa I, Yasutomi Y, Mizutani H. Administration of Ag85B showed therapeutic effects to Th2-type cytokine-mediated acute phase atopic dermatitis by inducing regulatory T cells. Arch Dermatol Res. 2009;301:151-7 pubmed publisher
    ..the effect of plasmid DNA encoding Ag85B derived from Mycobacterium kansasii on AD skin lesions induced by oxazolone (OX) application...
  5. Yu H, Venkatarangan L, Wishnok J, Tannenbaum S. Quantitation of four guanine oxidation products from reaction of DNA with varying doses of peroxynitrite. Chem Res Toxicol. 2005;18:1849-57 pubmed
    ..8-oxodG), 2,2-diamino-4[(2-deoxy-beta-d-erythro-pentafuranosyl)amino]-5(2H)-oxazolone (oxazolone), spiroiminodihydantoin, and N1-(beta-d-erythro-pentofuranosyl)-5-guanidinohydantoin (..
  6. Schneider G. Immunological competence in Snell-Bagg pituitary dwarf mice: response to the contact-sensitizing agent oxazolone. Am J Anat. 1976;145:371-93 pubmed
    ..Therefore, this investigation was undertaken to study the response of dwarf mice to the hapten, oxazolone, which produces one type of T-cell-dependent response, delayed hypersensitivity, and to compare this response to ..
  7. Yeom M, Kim S, Lee B, Han J, Chung G, Choi H, et al. Oral administration of glucosylceramide ameliorates inflammatory dry-skin condition in chronic oxazolone-induced irritant contact dermatitis in the mouse ear. J Dermatol Sci. 2012;67:101-10 pubmed publisher
    ..A major characteristic of chronic ICD is an inflammatory dry-skin condition with associated itching. Although glucosylceramide (GlcCer) is known to improve the skin barrier function, its mechanism of action is unknown...
  8. Yang J, Zhao J, Nakaguchi T, Gregersen H. Biomechanical changes in oxazolone-induced colitis in BALB/C mice. J Biomech. 2009;42:811-7 pubmed publisher
    ..The aim was to study acute morphological and biomechanical properties of the distal colon in oxazolone-induced UC in BALB/C mice. Six normal male BALB/C mice and 10 oxazolone-induced UC mice were studied...
  9. Norman M, Hwang J, Hulliger S, Bonder C, Yamanouchi J, Santamaria P, et al. Mast cells regulate the magnitude and the cytokine microenvironment of the contact hypersensitivity response. Am J Pathol. 2008;172:1638-49 pubmed publisher
    ..CS in both W/Wv mast cell-deficient and wild-type mice in response to different immunizing doses of hapten (oxazolone)...

More Information


  1. Wang X, Ouyang Q, Luo W. Oxazolone-induced murine model of ulcerative colitis. Chin J Dig Dis. 2004;5:165-8 pubmed
    ..The aim of the present study was to set up an oxazolone-induced murine colitis model and use it to research the pathogenesis of inflammatory bowel disease...
  2. Nolte T, Zadeh Khorasani M, Safarov O, Rueff F, Varga R, Herbach N, et al. Induction of oxazolone-mediated features of atopic dermatitis in NOD-scid IL2R?(null) mice engrafted with human peripheral blood mononuclear cells. Dis Model Mech. 2013;6:125-34 pubmed publisher
    ..Here, we examine the induction of oxazolone-mediated features of atopic dermatitis (AD) in NOD-scid IL2R?(null) mice engrafted with human peripheral blood ..
  3. Koeper L, Schulz A, Ahr H, Vohr H. In vitro differentiation of skin sensitizers by cell signaling pathways. Toxicology. 2007;242:144-52 pubmed
    ..skin models (epidermal model EST-1000 and full-thickness model AST-2000) were exposed to sensitizing (oxazolone and DNFB) or irritant compounds (SDS and TritonX-100)...
  4. Bryce P, Miller M, Miyajima I, Tsai M, Galli S, Oettgen H. Immune sensitization in the skin is enhanced by antigen-independent effects of IgE. Immunity. 2004;20:381-92 pubmed
    ..We speculate that levels of IgE normally present in mice favor immune sensitization via antigen-independent but FcepsilonRI-dependent effects on mast cells. ..
  5. Sheu M, Fowler A, Kao J, Schmuth M, Schoonjans K, Auwerx J, et al. Topical peroxisome proliferator activated receptor-alpha activators reduce inflammation in irritant and allergic contact dermatitis models. J Invest Dermatol. 2002;118:94-101 pubmed
  6. Christensen A, Skov S, Haase C. Local and systemic effects of co-stimulatory blockade using cytotoxic T lymphocyte antigen-4-immunoglobulin in dinitrofluorobenzene- and oxazolone-induced contact hypersensitivity in mice. Clin Exp Immunol. 2013;171:220-30 pubmed publisher
    ..We observed a dose-dependent suppression of the ear swelling in both dinitrofluorobenzene (DNFB)- and oxazolone-induced CHS...
  7. Lee J, Jung K, Bae I, Cho S, Seo D, Lee S, et al. Anti-inflammatory and barrier protecting effect of Lithospermum erythrorhizon extracts in chronic oxazolone-induced murine atopic dermatitis. J Dermatol Sci. 2009;56:64-6 pubmed publisher
  8. Farraj A, Harkema J, Kaminski N. Allergic rhinitis induced by intranasal sensitization and challenge with trimellitic anhydride but not with dinitrochlorobenzene or oxazolone in A/J mice. Toxicol Sci. 2004;79:315-25 pubmed
    ..known chemical respiratory allergen TMA, but not the nonrespiratory sensitizers dinitrochlorobenzene (DNCB) and oxazolone (OXA), will induce characteristic features of LMW chemical-induced allergic airway disease in the nasal and ..
  9. Perkins B, Chamot Rooke J, Yoon S, Gucinski A, Somogyi A, Wysocki V. Evidence of diketopiperazine and oxazolone structures for HA b2+ ion. J Am Chem Soc. 2009;131:17528-9 pubmed publisher
    Peptide fragmentation can lead to an oxazolone or diketopiperazine b(2)(+) ion structure...
  10. Yoon S, Chamot Rooke J, Perkins B, Hilderbrand A, Poutsma J, Wysocki V. IRMPD spectroscopy shows that AGG forms an oxazolone b2+ ion. J Am Chem Soc. 2008;130:17644-5 pubmed publisher
    ..experimental spectrum for the b(2)(+) ion from protonated AGG matches best to the theoretical spectrum for an oxazolone structure protonated on the ring nitrogen...
  11. Subramaniam M, Saffaripour S, Watson S, Mayadas T, Hynes R, Wagner D. Reduced recruitment of inflammatory cells in a contact hypersensitivity response in P-selectin-deficient mice. J Exp Med. 1995;181:2277-82 pubmed
    The inflammatory response at sites of contact hypersensitivity induced by oxazolone was examined in the ears of P-selectin-deficient and wild-type mice...
  12. Chen X, Yu L, Steill J, Oomens J, Polfer N. Effect of peptide fragment size on the propensity of cyclization in collision-induced dissociation: oligoglycine b(2)-b(8). J Am Chem Soc. 2009;131:18272-82 pubmed publisher
    ..insights from these results yield compelling evidence that smaller b(n) fragments (n = 2, 3) exclusively adopt oxazolone-type structures, whereas a mixture of oxazolone and macrocycle b fragment structures are formed for midsized b(n)..
  13. Rosen M, Chaturvedi R, Washington M, Kuhnhein L, Moore P, Coggeshall S, et al. STAT6 deficiency ameliorates severity of oxazolone colitis by decreasing expression of claudin-2 and Th2-inducing cytokines. J Immunol. 2013;190:1849-58 pubmed publisher
    ..In this study, we investigated the role of STAT6 in oxazolone colitis, a murine model of UC, by inducing colitis in STAT6-deficient (STAT6(-/-)) and wild type (WT) mice...
  14. Lehtimäki S, Tillander S, Puustinen A, Matikainen S, Nyman T, Fyhrquist N, et al. Absence of CCR4 exacerbates skin inflammation in an oxazolone-induced contact hypersensitivity model. J Invest Dermatol. 2010;130:2743-51 pubmed publisher
    ..We studied the effects of CCR4 deficiency in the murine model of oxazolone-induced contact hypersensitivity in CCR4-/- and wild-type (WT) mice...
  15. Heller F, Fuss I, Nieuwenhuis E, Blumberg R, Strober W. Oxazolone colitis, a Th2 colitis model resembling ulcerative colitis, is mediated by IL-13-producing NK-T cells. Immunity. 2002;17:629-38 pubmed
    b>Oxazolone colitis (OC) is an experimental colitis that has a histologic resemblance to human ulcerative colitis...
  16. White H. Restriction-PCR fingerprinting of the immunoglobulin VH repertoire: direct detection of an immune response and global analysis of B cell clonality. Eur J Immunol. 1998;28:3268-79 pubmed
  17. Brunyánszki A, Hegedus C, Szántó M, Erdélyi K, Kovacs K, Schreiber V, et al. Genetic ablation of PARP-1 protects against oxazolone-induced contact hypersensitivity by modulating oxidative stress. J Invest Dermatol. 2010;130:2629-37 pubmed publisher
    ..CHS) reaction is a form of delayed-type of hypersensitivity caused by contact allergens such as oxazolone (OXA)...
  18. Kakurai M, Monteforte R, Suto H, Tsai M, Nakae S, Galli S. Mast cell-derived tumor necrosis factor can promote nerve fiber elongation in the skin during contact hypersensitivity in mice. Am J Pathol. 2006;169:1713-21 pubmed
    ..We found that contact hypersensitivity reactions to oxazolone in mice were associated with significant increases in the length of nerves in the epidermis and dermis...
  19. Hamidian H, Tagizadeh R, Fozooni S, Abbasalipour V, Taheri A, Namjou M. Synthesis of novel azo compounds containing 5(4H)-oxazolone ring as potent tyrosinase inhibitors. Bioorg Med Chem. 2013;21:2088-92 pubmed publisher
    Six new azo dyes containing of 5(4H)-oxazolone ring were prepared by diazotization of 4-aminohippuric acid and coupling with N,N-dimethylaniline, 1-naphthol and 2-naphthol and condensation with 4-fluoro benzaldehyde or 4-trifluoromethoxy ..
  20. Kobayashi M, Nunomura S, Gon Y, Endo D, Kishiro S, Fukunaga M, et al. Abrogation of high-affinity IgE receptor-mediated mast cell activation at the effector phase prevents contact hypersensitivity to oxazolone. J Invest Dermatol. 2010;130:725-31 pubmed publisher
    ..that optimal MC activation through the FcepsilonRI beta-chain ITAM has essential roles in the onset of CHS to oxazolone (Oxa), a well-characterized chemical allergen...
  21. Fowler A, Sheu M, Schmuth M, Kao J, Fluhr J, Rhein L, et al. Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. J Invest Dermatol. 2003;120:246-55 pubmed
    ..Both ear thickness and weight increased (approximately 1.5-fold) in the oxazolone-induced allergic dermatitis model, and 22ROH and GW3965 reduced inflammation by approximately 50% and ..
  22. Funding A, Johansen C, Gaestel M, Bibby B, Lilleholt L, Kragballe K, et al. Reduced oxazolone-induced skin inflammation in MAPKAP kinase 2 knockout mice. J Invest Dermatol. 2009;129:891-8 pubmed publisher
    ..This study investigates for the first time the role of MK2 in skin inflammation using the model of oxazolone-induced acute allergic contact dermatitis in mice...
  23. Brugman S, Liu K, Lindenbergh Kortleve D, Samsom J, Furuta G, Renshaw S, et al. Oxazolone-induced enterocolitis in zebrafish depends on the composition of the intestinal microbiota. Gastroenterology. 2009;137:1757-67.e1 pubmed publisher
    ..Enterocolitis was induced by intrarectal administration of the hapten oxazolone in adult wild-type and myeloperoxidase-reporter transgenic zebrafish in the presence or absence of antibiotics...
  24. Calou I, Sousa D, Cunha G, Brito G, Silveira E, Rao V, et al. Topically applied diterpenoids from Egletes viscosa (Asteraceae) attenuate the dermal inflammation in mouse ear induced by tetradecanoylphorbol 13-acetate- and oxazolone. Biol Pharm Bull. 2008;31:1511-6 pubmed
    ..effectively inhibited the delayed-type hypersensitivity reaction induced by repeated topical application of 1% oxazolone (OXA, 20 microl/ear), as evidenced by significant decreases in ear thickness and interferon-gamma (INF-gamma) ..
  25. Oomens J, Young S, Molesworth S, Van Stipdonk M. Spectroscopic evidence for an oxazolone structure of the b(2) fragment ion from protonated tri-alanine. J Am Soc Mass Spectrom. 2009;20:334-9 pubmed publisher
    ..Instead, comparison of the IRMPD spectrum of b(2)(+) to spectra predicted by density functional theory provides compelling evidence for an oxazolone structure protonated at the oxazolone N-atom.
  26. Kino K, Takao M, Miyazawa H, Hanaoka F. A DNA oligomer containing 2,2,4-triamino-5(2H)-oxazolone is incised by human NEIL1 and NTH1. Mutat Res. 2012;734:73-7 pubmed publisher
    The nucleobase derivative, 2,2,4-triamino-5(2H)-oxazolone (Oz), is an oxidation product of guanine or of 8-oxo-7,8-dihydroguanine that causes G-to-C transversions in DNA...
  27. Harrison A, Young A. Fragmentation of deprotonated N-benzoylpeptides: formation of deprotonated oxazolones. J Am Soc Mass Spectrom. 2004;15:446-56 pubmed
    ..This observation is rationalized in terms of formation of deprotonated 2-phenyl-5-oxazolone. Various pathways to the deprotonated oxazolone have been elucidated through MS3 experiments...
  28. Bryniarski K, Biedron R, Jakubowski A, Chlopicki S, Marcinkiewicz J. Anti-inflammatory effect of 1-methylnicotinamide in contact hypersensitivity to oxazolone in mice; involvement of prostacyclin. Eur J Pharmacol. 2008;578:332-8 pubmed
    ..effects of MNA and its parent molecule, nicotinamide, in the contact hypersensitivity reaction to oxazolone in CBA/J inbred mice...
  29. Hatano Y, Man M, Uchida Y, Crumrine D, Scharschmidt T, Kim E, et al. Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis. J Invest Dermatol. 2009;129:1824-35 pubmed publisher
    ..of the polyhydroxyl acid, lactobionic acid, during the repeated-challenge phase inhibited the development of oxazolone-induced atopic dermatitis (AD)...
  30. Huang Z, Jiang Y, Yang Y, Shao J, Sun X, Chen J, et al. 3,3'-Diindolylmethane alleviates oxazolone-induced colitis through Th2/Th17 suppression and Treg induction. Mol Immunol. 2013;53:335-44 pubmed publisher
    ..The therapeutic effects of DIM were studied in an oxazolone-induced colitis model...
  31. Fichtner Feigl S, Strober W, Kawakami K, Puri R, Kitani A. IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis. Nat Med. 2006;12:99-106 pubmed
    ..In vivo, we found that prevention of IL-13Ralpha(2) expression reduced production of TGF-beta(1) in oxazolone-induced colitis and that prevention of IL-13Ralpha(2) expression, Il13ra2 gene silencing or blockade of IL-..
  32. Watanabe T, Yamamoto T, Yoshida M, Fujiwara K, Kageyama Yahara N, Kuramoto H, et al. The traditional herbal medicine saireito exerts its inhibitory effect on murine oxazolone-induced colitis via the induction of Th1-polarized immune responses in the mucosal immune system of the colon. Int Arch Allergy Immunol. 2010;151:98-106 pubmed publisher
    ..We analyzed the immunological characteristics of an oxazolone (OXZ)-induced colitis (OC) model and examined the effects of sareito on this model...
  33. Engel M, Khalil M, Siklosi N, Mueller Tribbensee S, Neuhuber W, Neurath M, et al. Opposite effects of substance P and calcitonin gene-related peptide in oxazolone colitis. Dig Liver Dis. 2012;44:24-9 pubmed publisher
    ..b>Oxazolone (4-ethoxymethylene-2-phenyl-2-oxazolin-5-one) colitis was induced in wild-type (WT), SP and CGRP knockout ((-/-))..
  34. Shimada Y, Hasegawa M, Kaburagi Y, Hamaguchi Y, Komura K, Saito E, et al. L-selectin or ICAM-1 deficiency reduces an immediate-type hypersensitivity response by preventing mast cell recruitment in repeated elicitation of contact hypersensitivity. J Immunol. 2003;170:4325-34 pubmed
  35. Scharschmidt T, Man M, Hatano Y, Crumrine D, Gunathilake R, Sundberg J, et al. Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens. J Allergy Clin Immunol. 2009;124:496-506, 506.e1-6 pubmed publisher
    ..FLG deficiency alone provokes a paracellular barrier abnormality in mice that reduces inflammatory thresholds to topical irritants/haptens, likely accounting for enhanced antigen penetration in FLG-associated AD. ..
  36. Lamprecht A, Yamamoto H, Takeuchi H, Kawashima Y. Nanoparticles enhance therapeutic efficiency by selectively increased local drug dose in experimental colitis in rats. J Pharmacol Exp Ther. 2005;315:196-202 pubmed
    ..treatment by free drug was not different from colitis control in both 2,4,6-trinitrobenzenesulfonic acid and oxazolone colitis model...
  37. Lange Asschenfeldt B, Weninger W, Velasco P, Kyriakides T, von Andrian U, Bornstein P, et al. Increased and prolonged inflammation and angiogenesis in delayed-type hypersensitivity reactions elicited in the skin of thrombospondin-2--deficient mice. Blood. 2002;99:538-45 pubmed
    ..were elicited in the ear skin of wild-type and TSP-2-deficient mice by topical sensitization and challenge with oxazolone. Cutaneous TSP-2 expression was up-regulated in the inflamed skin of wild-type mice, predominantly in dermal ..
  38. Misiaszek R, Crean C, Joffe A, Geacintov N, Shafirovich V. Oxidative DNA damage associated with combination of guanine and superoxide radicals and repair mechanisms via radical trapping. J Biol Chem. 2004;279:32106-15 pubmed
    ..The mechanistic aspects of the radical reactions that either regenerate undamaged guanine in DNA or lead to oxidatively modified guanine bases are discussed. ..
  39. Behling L, Hartsel S, Lewis D, DiSpirito A, Choi D, Masterson L, et al. NMR, mass spectrometry and chemical evidence reveal a different chemical structure for methanobactin that contains oxazolone rings. J Am Chem Soc. 2008;130:12604-5 pubmed publisher
    ..Our data also indicate that oxazolone rings instead of hydroxyimidazolate rings form the core of the two chromophoric residues...
  40. Staite N, Justen J, Sly L, Beaudet A, Bullard D. Inhibition of delayed-type contact hypersensitivity in mice deficient in both E-selectin and P-selectin. Blood. 1996;88:2973-9 pubmed
    ..b>Oxazolone-induced increases in ear thickness and ear weight were equivalent in wild-type mice and in P-selectin and E-..
  41. Chen X, Steill J, Oomens J, Polfer N. Oxazolone versus macrocycle structures for Leu-enkephalin b2-b4: insights from infrared multiple-photon dissociation spectroscopy and gas-phase hydrogen/deuterium exchange. J Am Soc Mass Spectrom. 2010;21:1313-21 pubmed publisher
    ..Infrared spectroscopy reveals that b(2) exclusively adopts oxazolone structures, protonated at the N-terminus and at the oxazolone ring N, based on the presence and absence of ..
  42. Kojima R, Kuroda S, Ohkishi T, Nakamaru K, Hatakeyama S. Oxazolone-induced colitis in BALB/C mice: a new method to evaluate the efficacy of therapeutic agents for ulcerative colitis. J Pharmacol Sci. 2004;96:307-13 pubmed
    ..In recent years, the murine oxazolone (OXA)-induced colitis model came to be accepted as a Th-2 type model, but it has yet to be used in any ..
  43. O Leary J, Goodarzi M, Drayton D, von Andrian U. T cell- and B cell-independent adaptive immunity mediated by natural killer cells. Nat Immunol. 2006;7:507-16 pubmed
    ..T cells and B cells demonstrated substantial contact hypersensitivity responses to 2,4-dinitrofluorobenzene and oxazolone. Those responses were adaptive in nature, as they persisted for at least 4 weeks and were elicited only by ..
  44. Itakura A, Kikuchi Y, Kouro T, Ikutani M, Takaki S, Askenase P, et al. Interleukin 5 plays an essential role in elicitation of contact sensitivity through dual effects on eosinophils and B-1 cells. Int Arch Allergy Immunol. 2006;140 Suppl 1:8-16 pubmed
    ..IL-5 receptor alpha-chain-deficient (IL-5Ralpha-/-) mice and IL-5Ralpha+/+ mice were contact sensitized with oxazolone hapten...
  45. He C, Young A, West C, Su M, Konerding M, Mentzer S. Stimulation of regional lymphatic and blood flow by epicutaneous oxazolone. J Appl Physiol (1985). 2002;93:966-73 pubmed
    The application of the epicutaneous antigen oxazolone results in persistent induration and erythema; however, the relative changes in lymph and blood flow in the inflammatory skin are largely unknown...
  46. Bleiholder C, Suhai S, Harrison A, Paizs B. Towards understanding the tandem mass spectra of protonated oligopeptides. 2: The proline effect in collision-induced dissociation of protonated Ala-Ala-Xxx-Pro-Ala (Xxx = Ala, Ser, Leu, Val, Phe, and Trp). J Am Soc Mass Spectrom. 2011;22:1032-9 pubmed publisher
    ..In the post-cleavage phase of fragmentation the N-terminal oxazolone fragment with the Ala-Ala-Xxx sequence and Pro-Ala compete for the ionizing proton for these peptides...
  47. Siscovick J, Zapolanski T, Magro C, Carrington K, Prograis S, Nussbaum M, et al. Polypodium leucotomos inhibits ultraviolet B radiation-induced immunosuppression. Photodermatol Photoimmunol Photomed. 2008;24:134-41 pubmed publisher
    ..UVB-induced murine skin cancers occur, in part, because of UVB-induced immunosuppression. Thus, we examined whether PL inhibits UVB-suppression of the induction of contact hypersensitivity (CHS) locally or systemically...
  48. Brugman S, Nieuwenhuis E. Oxazolone-Induced Intestinal Inflammation in Adult Zebrafish. Methods Mol Biol. 2017;1559:311-318 pubmed publisher
    ..Here, we describe a method to induce intestinal inflammation by intra-rectal injection of the hapten oxazolone in adult zebrafish.
  49. Kawagoe J, Takizawa T, Matsumoto J, Tamiya M, Meek S, Smith A, et al. Effect of protease-activated receptor-2 deficiency on allergic dermatitis in the mouse ear. Jpn J Pharmacol. 2002;88:77-84 pubmed
    ..Ear thickness, contact hypersensitivity (CH) induced by topical application of picryl chloride (PC) or oxazolone (Ox) after sensitization, and vascular permeability after ear passive cutaneous anaphylaxis (PCA) were compared ..
  50. Cumberbatch M, Dearman R, Kimber I. Constitutive and inducible expression of interleukin-6 by Langerhans cells and lymph node dendritic cells. Immunology. 1996;87:513-8 pubmed
    ..Keratinocytes expressed detectable IL-6 only following local exposure to the contact allergen oxazolone. Such treatment also appeared to enhance the expression by epidermal dendritic cells of this cytokine...
  51. Dong S, Liu X, Zhu Y, He P, Lin L, Feng X. Organocatalytic oxyamination of azlactones: kinetic resolution of oxaziridines and asymmetric synthesis of oxazolin-4-ones. J Am Chem Soc. 2013;135:10026-9 pubmed publisher
    ..The triple stereodifferentiation process was also studied via control experiments. ..
  52. Mihalik B, Pálvölgyi A, Bogár F, Megyeri K, Ling I, Barkoczy J, et al. Loop-F of the ?-subunit determines the pharmacologic profile of novel competitive inhibitors of GABAA receptors. Eur J Pharmacol. 2017;798:129-136 pubmed publisher
    ..Testing of a compound with altered regiochemistry of the oxazolone moiety supported the model with respect to the conserved GABA-interacting residues in vitro as well as in vivo...
  53. Dwyer K, Barrett P, Chan D, Foo J, Watts G, Croft K. Oxazolinone derivative of leucine for GC-MS: a sensitive and robust method for stable isotope kinetic studies of lipoproteins. J Lipid Res. 2002;43:344-9 pubmed
    ..In conclusion, the oxazolinone derivative provides a robust and simple procedure for the sensitive analysis of isotopic enrichment for metabolic studies of human lipoproteins. ..