dantrolene

Summary

Summary: Skeletal muscle relaxant that acts by interfering with excitation-contraction coupling in the muscle fiber. It is used in spasticity and other neuromuscular abnormalities. Although the mechanism of action is probably not central, dantrolene is usually grouped with the central muscle relaxants.

Top Publications

  1. Toppin P, Chandy T, Ghanekar A, Kraeva N, Beattie W, Riazi S. A report of fulminant malignant hyperthermia in a patient with a novel mutation of the CACNA1S gene. Can J Anaesth. 2010;57:689-93 pubmed publisher
    ..The homozygous p.Arg1086Ser mutation of CACNA1S, the gene that encodes the alpha-1-subunit of the voltage-gated skeletal muscle L-type calcium channel, is a novel mutation associated with malignant hyperthermia. ..
  2. Majidi S, Grigoryan M, Tekle W, Qureshi A. Intra-arterial dantrolene for refractory cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Neurocrit Care. 2012;17:245-9 pubmed publisher
    Intravenous dantrolene has been used to prevent and treat cerebral vasospasm. We report a case of refractory cerebral vasospasm treated with intra-arterial dantrolene after aneurysmal subarachnoid hemorrhage...
  3. Hassoun S, Marechal X, Montaigne D, Bouazza Y, Decoster B, Lancel S, et al. Prevention of endotoxin-induced sarcoplasmic reticulum calcium leak improves mitochondrial and myocardial dysfunction. Crit Care Med. 2008;36:2590-6 pubmed publisher
    ..was mainly characterized by reduced sarcoplasmic reticulum Ca2+ uptake and Ca2+ leak, we tested whether dantrolene, a sarco(endo)plasmic reticulum calcium ATPase leak inhibitor, would prevent mitochondrial and cardiac ..
  4. Li F, Hayashi T, Jin G, Deguchi K, Nagotani S, Nagano I, et al. The protective effect of dantrolene on ischemic neuronal cell death is associated with reduced expression of endoplasmic reticulum stress markers. Brain Res. 2005;1048:59-68 pubmed
    ..In order to determine the effect of dantrolene, a ryanodine receptor antagonist, on ER stress response and ischemic brain injury, we investigated changes in ER ..
  5. Gepdiremen A, Buyukokuroglu M, Duzenli S. Dantrolene exerts protective activity in double and triple combination with nimodipine, ruthenium red and basilene blue in bilirubin-induced neurotoxicity in cell culture of rats. Int J Neurosci. 2009;119:1602-14 pubmed
    In the present study, dantrolene, nimodipine, basilen blue, and ruthenium red were tested in experimental bilirubin toxicity in cortical cell culture of rats. Neurotoxicity was induced by 10(-4) M bilirubin...
  6. Lisk G, Kang M, Cohn J, Desai S. Specific inhibition of the plasmodial surface anion channel by dantrolene. Eukaryot Cell. 2006;5:1882-93 pubmed
    ..We recently identified a family of new PSAC antagonists structurally related to dantrolene, an antagonist of muscle Ca++ release channels...
  7. Reulbach U, Dütsch C, Biermann T, Sperling W, Thuerauf N, Kornhuber J, et al. Managing an effective treatment for neuroleptic malignant syndrome. Crit Care. 2007;11:R4 pubmed
    ..The aim of this study was to prove the efficacy of different NMS treatment strategies, focusing on the efficacy of dantrolene.
  8. Bannister R. Dantrolene-induced inhibition of skeletal L-type Ca2+ current requires RyR1 expression. Biomed Res Int. 2013;2013:390493 pubmed publisher
    ..1). The only effective treatment for an MH crisis is administration of the hydantoin derivative Dantrolene. In addition to reducing voltage induced Ca(2+) release from the sarcoplasmic reticulum, Dantrolene was recently ..
  9. Kumata K, Ogawa M, Takei M, Fujinaga M, Yoshida Y, Nengaki N, et al. Radiosynthesis of [13N]dantrolene, a positron emission tomography probe for breast cancer resistant protein, using no-carrier-added [13N]ammonia. Bioorg Med Chem. 2012;20:305-10 pubmed publisher
    b>Dantrolene (1) is a substrate for breast cancer resistant protein, which is widely distributed in the blood-brain-barrier, intestine, gall bladder, and liver...

More Information

Publications62

  1. Liu J, Tang T, Tu H, Nelson O, Herndon E, Huynh D, et al. Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 2. J Neurosci. 2009;29:9148-62 pubmed publisher
    ..Glutamate-induced cell death of 58Q PC cultures was attenuated by dantrolene, a clinically relevant RyanR inhibitor and Ca(2+) stabilizer...
  2. Szentesi P, Collet C, Sarkozi S, Szegedi C, Jona I, Jacquemond V, et al. Effects of dantrolene on steps of excitation-contraction coupling in mammalian skeletal muscle fibers. J Gen Physiol. 2001;118:355-75 pubmed
    The effects of the muscle relaxant dantrolene on steps of excitation-contraction coupling were studied on fast twitch muscles of rodents...
  3. Kim B, Kim H, Mamura M, Ambudkar I, Choi K, Kim S. Tumor necrosis factor induces apoptosis in hepatoma cells by increasing Ca(2+) release from the endoplasmic reticulum and suppressing Bcl-2 expression. J Biol Chem. 2002;277:31381-9 pubmed
    ..b>Dantrolene suppressed the inhibitory effect of TNF on Bcl-2 expression...
  4. Bannister R, Pessah I, Beam K. The skeletal L-type Ca(2+) current is a major contributor to excitation-coupled Ca(2+) entry. J Gen Physiol. 2009;133:79-91 pubmed publisher
    ..ECCE pathway is blocked by pharmacological agents that also block store-operated Ca(2+) entry, is inhibited by dantrolene, is relatively insensitive to the DHP antagonist nifedipine (1 microM), and is permeable to Mn(2+)...
  5. Makarewicz D, Zieminska E, Łazarewicz J. Dantrolene inhibits NMDA-induced 45Ca uptake in cultured cerebellar granule neurons. Neurochem Int. 2003;43:273-8 pubmed
    b>Dantrolene is an inhibitor of a skeletal muscle subtype of ryanodine receptors that stabilizes intracellular calcium concentrations and exerts neuroprotective effects in neurons submitted to excitotoxic challenges...
  6. Smith J. Cooling methods used in the treatment of exertional heat illness. Br J Sports Med. 2005;39:503-7; discussion 507 pubmed
    ..Other methods include both evaporative and invasive techniques, and the use of chemical agents such as dantrolene. The main predictor of outcome in exertional heatstroke is the duration and degree of hyperthermia...
  7. Cherednichenko G, Ward C, Feng W, Cabrales E, Michaelson L, Samso M, et al. Enhanced excitation-coupled calcium entry in myotubes expressing malignant hyperthermia mutation R163C is attenuated by dantrolene. Mol Pharmacol. 2008;73:1203-12 pubmed publisher
    b>Dantrolene is the drug of choice for the treatment of malignant hyperthermia (MH) and is also useful for treatment of spasticity or muscle spasms associated with several clinical conditions...
  8. Wang R, Zhong X, Meng X, Koop A, Tian X, Jones P, et al. Localization of the dantrolene-binding sequence near the FK506-binding protein-binding site in the three-dimensional structure of the ryanodine receptor. J Biol Chem. 2011;286:12202-12 pubmed publisher
    b>Dantrolene is believed to stabilize interdomain interactions between the NH2-terminal and central regions of ryanodine receptors by binding to the NH2-terminal residues 590-609 in skeletal ryanodine receptor (RyR1) and residues 601-620 in ..
  9. Muehlschlegel S, Sims J. Dantrolene: mechanisms of neuroprotection and possible clinical applications in the neurointensive care unit. Neurocrit Care. 2009;10:103-15 pubmed publisher
    Calcium plays a central role in neuronal function and injury. Dantrolene, an inhibitor of the ryanodine receptor, inhibits intracellular calcium release from the sarco-endoplasmic reticulum...
  10. Inan S, Wei H. The cytoprotective effects of dantrolene: a ryanodine receptor antagonist. Anesth Analg. 2010;111:1400-10 pubmed publisher
    ..b>Dantrolene, the primary drug to treat malignant hyperthermia, is a ryanodine receptor antagonist...
  11. Kobayashi S, Yano M, Uchinoumi H, Suetomi T, Susa T, Ono M, et al. Dantrolene, a therapeutic agent for malignant hyperthermia, inhibits catecholaminergic polymorphic ventricular tachycardia in a RyR2(R2474S/+) knock-in mouse model. Circ J. 2010;74:2579-84 pubmed
    b>Dantrolene, a specific agent for the treatment of malignant hyperthermia, was found to inhibit Ca(2+) leak through not only the skeletal ryanodine receptor (RyR1), but also the cardiac ryanodine receptor (RyR2) by correcting the defective ..
  12. Krause T, Gerbershagen M, Fiege M, Weisshorn R, Wappler F. Dantrolene--a review of its pharmacology, therapeutic use and new developments. Anaesthesia. 2004;59:364-73 pubmed
    ..The skeletal muscle relaxant dantrolene is the only currently available drug for specific and effective therapy of this syndrome in man...
  13. Kobayashi S, Yano M, Suetomi T, Ono M, Tateishi H, Mochizuki M, et al. Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor. J Am Coll Cardiol. 2009;53:1993-2005 pubmed publisher
    We sought to investigate the effect of dantrolene, a drug generally used to treat malignant hyperthermia, on the Ca2+ release and cardiomyocyte function in failing hearts.
  14. Nakayama R, Yano T, Ushijima K, Abe E, Terasaki H. Effects of dantrolene on extracellular glutamate concentration and neuronal death in the rat hippocampal CA1 region subjected to transient ischemia. Anesthesiology. 2002;96:705-10 pubmed
    ..b>Dantrolene inhibits calcium release from intracellular calcium stores...
  15. Peng J, Liang G, Inan S, Wu Z, Joseph D, Meng Q, et al. Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice. Neurosci Lett. 2012;516:274-9 pubmed publisher
    ..We investigated the therapeutic effect of dantrolene, a ryanodine receptor antagonist, on cognitive dysfunction and neuropathology in the triple transgenic Alzheimer ..
  16. Hosoya T, Aoyama H, Ikemoto T, Kihara Y, Hiramatsu T, Endo M, et al. Dantrolene analogues revisited: general synthesis and specific functions capable of discriminating two kinds of Ca2+ release from sarcoplasmic reticulum of mouse skeletal muscle. Bioorg Med Chem. 2003;11:663-73 pubmed
    The general synthesis of dantrolene analogues with various substituents on its phenyl ring has been developed via palladium-catalyzed cross-coupling reactions, the Stille or Suzuki reaction, as the key step...
  17. Popescu B, Oprica M, Sajin M, Stanciu C, Bajenaru O, Predescu A, et al. Dantrolene protects neurons against kainic acid induced apoptosis in vitro and in vivo. J Cell Mol Med. 2002;6:555-69 pubmed
    ..We report that dantrolene, a specific ryanodine receptor antagonist, was able to significantly reduce the apoptotic cell death in CGC ..
  18. Hattori H, Nagata E, Oya Y, Takahashi T, Aoki M, Ito D, et al. A novel compound heterozygous dysferlin mutation in Miyoshi myopathy siblings responding to dantrolene. Eur J Neurol. 2007;14:1288-91 pubmed
    ..We had observed the decreased serum creatine kinase (CK) before and after administration of dantrolene in the elder brother and the increased serum CK before and after discontinuance of the drug on suspicion of drug-..
  19. Duzenli S, Bakuridze K, Gepdiremen A. The effects of ruthenium red, dantrolene and nimodipine, alone or in combination, in NMDA induced neurotoxicity of cerebellar granular cell culture of rats. Toxicol In Vitro. 2005;19:589-94 pubmed
    ..we used the L-type calcium channel blocker nimodipine, the endoplasmic reticulum (ER) calcium release blocker dantrolene and the calcium transport blocker in mitochondria ruthenium red (RuR), in NMDA induced neurotoxicity, to observe ..
  20. Benders A, Veerkamp J, Oosterhof A, Jongen P, Bindels R, Smit L, et al. Ca2+ homeostasis in Brody's disease. A study in skeletal muscle and cultured muscle cells and the effects of dantrolene an verapamil. J Clin Invest. 1994;94:741-8 pubmed
    ..Addition of dantrolene or verapamil after the maximal response accelerates the restoration of the [Ca2+]i in these muscle cells...
  21. Orliaguet G, Langeron O, Coirault C, Fratea S, Coriat P, Riou B. Effects of dantrolene on rat diaphragm muscle during postnatal maturation. Anesthesiology. 2001;94:468-74 pubmed
    b>Dantrolene is the only known effective treatment for malignant hyperthermia. However, its effects on diaphragm muscle during postnatal maturation remain unknown...
  22. Paul Pletzer K, Yamamoto T, Ikemoto N, Jimenez L, Morimoto H, Williams P, et al. Probing a putative dantrolene-binding site on the cardiac ryanodine receptor. Biochem J. 2005;387:905-9 pubmed
    b>Dantrolene is an inhibitor of intracellular Ca2+ release from skeletal muscle SR (sarcoplasmic reticulum)...
  23. Muehlschlegel S, Rordorf G, Sims J. Effects of a single dose of dantrolene in patients with cerebral vasospasm after subarachnoid hemorrhage: a prospective pilot study. Stroke. 2011;42:1301-6 pubmed publisher
    ..We investigated the feasibility and safety of a single dose of intravenous dantrolene and its effect on transcranial Doppler in cerebral vasospasm after subarachnoid hemorrhage...
  24. Denborough M. Malignant hyperthermia. Lancet. 1998;352:1131-6 pubmed
    ..This knowledge has led to a specific muscle test to identify susceptibility to MH and to a specific treatment, dantrolene; and as a result the case-fatality rate in MH has fallen from 70% in the 1970s to 5% today...
  25. Paul Pletzer K, Yamamoto T, Bhat M, Ma J, Ikemoto N, Jimenez L, et al. Identification of a dantrolene-binding sequence on the skeletal muscle ryanodine receptor. J Biol Chem. 2002;277:34918-23 pubmed
    b>Dantrolene is a drug that suppresses intracellular Ca(2+) release from sarcoplasmic reticulum (SR) in skeletal muscle and is used as a therapeutic agent in individuals susceptible to malignant hyperthermia...
  26. Kobayashi S, Bannister M, Gangopadhyay J, Hamada T, Parness J, Ikemoto N. Dantrolene stabilizes domain interactions within the ryanodine receptor. J Biol Chem. 2005;280:6580-7 pubmed
    ..b>Dantrolene, a drug used to treat MH, binds to a region within this proposed domain switch...
  27. Chen X, Tang T, Tu H, Nelson O, Pook M, Hammer R, et al. Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3. J Neurosci. 2008;28:12713-24 pubmed publisher
    ..We found that feeding SCA3-YAC-84Q transgenic mice with dantrolene, a clinically relevant stabilizer of intracellular Ca(2+) signaling, improved their motor performance and ..
  28. Zhao F, Li P, Chen S, Louis C, Fruen B. Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity. J Biol Chem. 2001;276:13810-6 pubmed
    As an inhibitor of Ca(2+) release through ryanodine receptor (RYR) channels, the skeletal muscle relaxant dantrolene has proven to be both a valuable experimental probe of intracellular Ca(2+) signaling and a lifesaving treatment for the ..
  29. Jung C, Moretti A, Mederos y Schnitzler M, Iop L, Storch U, Bellin M, et al. Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia. EMBO Mol Med. 2012;4:180-91 pubmed publisher
    ..This was due to increased frequency and duration of elementary Ca(2+) release events (Ca(2+) sparks). Dantrolene, a drug effective on malignant hyperthermia, restored normal Ca(2+) spark properties and rescued the ..
  30. Paul Pletzer K, Palnitkar S, Jimenez L, Morimoto H, Parness J. The skeletal muscle ryanodine receptor identified as a molecular target of [3H]azidodantrolene by photoaffinity labeling. Biochemistry. 2001;40:531-42 pubmed
    b>Dantrolene is a skeletal muscle relaxant which acts by inhibiting intracellular Ca(2+) release from sarcoplasmic reticulum (SR)...
  31. Brandom B, Larach M, Chen M, Young M. Complications associated with the administration of dantrolene 1987 to 2006: a report from the North American Malignant Hyperthermia Registry of the Malignant Hyperthermia Association of the United States. Anesth Analg. 2011;112:1115-23 pubmed publisher
    b>Dantrolene is the only specific treatment for malignant hyperthermia (MH), a genetic disorder in which life-threatening temperature increase has been induced by inhalation anesthetics and succinylcholine...
  32. Oulès B, Del Prete D, Greco B, Zhang X, Lauritzen I, Sevalle J, et al. Ryanodine receptor blockade reduces amyloid-? load and memory impairments in Tg2576 mouse model of Alzheimer disease. J Neurosci. 2012;32:11820-34 pubmed
    ..Interestingly, dantrolene-induced lowering of RyR-mediated Ca²? release leads to the reduction of both intracellular and extracellular A? ..
  33. Hosoya T, Aoyama H, Ikemoto T, Hiramatsu T, Kihara Y, Endo M, et al. [(125)I]-N-[(3-azido-5-iodo)benzyl]dantrolene and [(125)I]-N-[[3-iodo-5-(3-trifluoromethyl-3H-diazirin-3-yl)]benzyl]dantrolene: photoaffinity probes specific for the physiological Ca(2+) release from sarcoplasmic reticulum of skeletal muscle. Bioorg Med Chem Lett. 2002;12:3263-5 pubmed
    ..SR) of skeletal muscle, we designed specific photoaffinity probes based on the structural modification of dantrolene. Thus, GIF-0082 and GIF-0276 possessing azido- and trifluoromethyldiazirinyl-benzyl groups, respectively, at the ..
  34. Hosoya T, Hiramatsu T, Ikemoto T, Aoyama H, Ohmae T, Endo M, et al. Design of dantrolene-derived probes for radioisotope-free photoaffinity labeling of proteins involved in the physiological Ca2+ release from sarcoplasmic reticulum of skeletal muscle. Bioorg Med Chem Lett. 2005;15:1289-94 pubmed
    Bifunctional dantrolene derivatives have been synthesized as probes for radioisotope-free photoaffinity labeling with the aim of elucidating the molecular mechanism of skeletal muscle contraction...
  35. Ikemoto T, Hosoya T, Aoyama H, Kihara Y, Suzuki M, Endo M. Effects of dantrolene and its derivatives on Ca(2+) release from the sarcoplasmic reticulum of mouse skeletal muscle fibres. Br J Pharmacol. 2001;134:729-36 pubmed
    1. We analysed the effect of dantrolene (Dan) and five newly synthesized derivatives (GIFs) on Ca(2+) release from the sarcoplasmic reticulum (SR) of mouse skeletal muscle. 2...
  36. Terada S, Muraoka I, Tabata I. Changes in [Ca2+]i induced by several glucose transport-enhancing stimuli in rat epitrochlearis muscle. J Appl Physiol (1985). 2003;94:1813-20 pubmed
  37. Muehlschlegel S, Rordorf G, Bodock M, Sims J. Dantrolene mediates vasorelaxation in cerebral vasoconstriction: a case series. Neurocrit Care. 2009;10:116-21 pubmed publisher
    ..b>Dantrolene, a ryanodine receptor antagonist, inhibits intracellular calcium release from the sarco-endoplasmic reticulum...
  38. Zhang H, Sun S, Herreman A, De Strooper B, Bezprozvanny I. Role of presenilins in neuronal calcium homeostasis. J Neurosci. 2010;30:8566-80 pubmed publisher
    ..Long-term feeding of the RyanR inhibitor dantrolene to amyloid precursor protein-presenilin-1 mice (Thy1-APP(KM670/671NL), Thy1-PS1(L166P)) resulted in an increased ..
  39. Choi R, Koenig X, Launikonis B. Dantrolene requires Mg2+ to arrest malignant hyperthermia. Proc Natl Acad Sci U S A. 2017;114:4811-4815 pubmed publisher
    ..Genetic predisposition mainly arises from mutations on the skeletal muscle ryanodine receptor (RyR). Dantrolene is administered to alleviate MH symptoms, but its mechanism of action and its influence on the Ca2+ ..
  40. Kamitani K, Yoshida H, Arai R, Matsuura K, Miyoshi H, Kuroda Y. [Case of suspected malignant hyperthermia following local infiltration anesthesia]. Masui. 2012;61:866-8 pubmed
    ..Although intravenous diazepam was not effective for increased body temperature, tachycardia, and convulsion, dantrolene was effective for these signs. However, blood test showed no abnormal finding...
  41. Grunau B, Wiens M, Brubacher J. Dantrolene in the treatment of MDMA-related hyperpyrexia: a systematic review. CJEM. 2010;12:435-42 pubmed
    The use of dantrolene in the treatment of hyperpyrexia related to MDMA (3,4-methylenedioxymethamphetamine) is controversial, with little data available to guide clinical decision-making...
  42. Lee S, Lee J, Song Y, Hwang D, Kim Y, Nam S, et al. Ryanodine receptor-mediated interference of neuronal cell differentiation by presenilin 2 mutation. J Neurosci Res. 2005;82:542-50 pubmed
    ..Moreover, dantrolene, a blocker of RyR reduced the PS2 mutation-induced interference of cell differentiation and calcium release, but ..
  43. Sawisky G, Chang J. Intracellular calcium involvement in pituitary adenylate cyclase-activating polypeptide stimulation of growth hormone and gonadotrophin secretion in goldfish pituitary cells. J Neuroendocrinol. 2005;17:353-71 pubmed
    ..Pretreatment with caffeine abolished the GH and GTH-II responses to PACAP. Dantrolene attenuated PACAP-elicited GTH-II release but did not affect the GH response, whereas ryanodine and 8-bromo-cADP ..
  44. Buyukokuroglu M, Taysi S, Buyukavci M, Bakan E. Prevention of acute adriamycin cardiotoxicity by dantrolene in rats. Hum Exp Toxicol. 2004;23:251-6 pubmed
    Possible preventive effect of dantrolene against the peroxidative damage in rat heart which was induced by the administration of an acute dose of adriamycin (ADR, 20 mg/kg, i.p.) has been examined...
  45. Perry P, Wilborn C. Serotonin syndrome vs neuroleptic malignant syndrome: a contrast of causes, diagnoses, and management. Ann Clin Psychiatry. 2012;24:155-62 pubmed
    ..For NMS, dantrolene is the most effective evidence-based drug treatment whereas there are no evidence-based drug treatments for SS...
  46. Yoshida M, Sakai T. Dantrolene, a calcium-induced calcium release inhibitor, prevents the acquisition of amygdaloid kindling in rats, a model of experimental epilepsy. Tohoku J Exp Med. 2006;209:303-10 pubmed
    ..b>Dantrolene has an inhibitory action against Ca(2+) release from intracellular Ca(2+) stores...
  47. Buyukokuroglu M, Gulcin I, Oktay M, Küfrevioğlu O. In vitro antioxidant properties of dantrolene sodium. Pharmacol Res. 2001;44:491-4 pubmed
    b>Dantrolene sodium is a skeletal muscle relaxant, which inhibits intracellular Ca2+ release from the sarcoplasmic reticulum. The aim of this study is to examine possible in vitro antioxidant effects of dantrolene sodium...
  48. Linazasoro G, Van Blercom N, Castro A, Dapena M. Subthalamic deep brain stimulation masking possible malignant syndrome in Parkinson disease. Neurology. 2004;63:589-90 pubmed
  49. Sajan M, Bandyopadhyay G, Kanoh Y, Standaert M, Quon M, Reed B, et al. Sorbitol activates atypical protein kinase C and GLUT4 glucose transporter translocation/glucose transport through proline-rich tyrosine kinase-2, the extracellular signal-regulated kinase pathway and phospholipase D. Biochem J. 2002;362:665-74 pubmed
    ..This mechanism contrasts with that of insulin, which primarily uses PI 3-kinase, D3-PO(4) polyphosphoinositides and PDK-1 to activate aPKCs. ..
  50. Nakamura N, Ueda T, Ishikawa R, Tasaka Y, Fukuuchi K, Sato N. Malignant hyperthermia developing during esophageal resection in an 82-year-old man. J Anesth. 2008;22:464-6 pubmed publisher
    ..0 degrees C. A rise of more than 0.5 degrees C in less than 15 min was seen, and MH was suspected. With dantrolene administration, the BT decreased from 40.9 degrees C at maximum to 37.7 degrees C...
  51. Bagni M, Colombini B, Geiger P, Berlinguer Palmini R, Cecchi G. Non-cross-bridge calcium-dependent stiffness in frog muscle fibers. Am J Physiol Cell Physiol. 2004;286:C1353-7 pubmed
    ..static stiffness by comparing static stiffness measurements in the presence of Ca(2+) release inhibitors (D600, Dantrolene, (2)H(2)O) and cross-bridge formation inhibitors [2,3-butanedione monoxime (BDM), hypertonicity]...
  52. Wooldridge A, Eades S, Hosgood G, Moore R. In vitro effects of oxytocin, acepromazine, detomidine, xylazine, butorphanol, terbutaline, isoproterenol, and dantrolene on smooth and skeletal muscles of the equine esophagus. Am J Vet Res. 2002;63:1732-7 pubmed
    To characterize the in vitro effects of oxytocin, acepromazine, xylazine, butorphanol, detomidine, dantrolene, isoproterenol, and terbutaline on skeletal and smooth muscle from the equine esophagus...
  53. Gepdiremen A, Duzenli S, Hacimuftuoglu A, Suleyman H, Oztas S. The effects of dantrolene alone or in combination with nimodipine in glutamate-induced neurotoxicity in cerebellar granular cell cultures of rat pups. Pharmacol Res. 2001;43:241-4 pubmed
    Despite the existence of some positive and negative reports on dantrolene in ischemic states, combined application of an endoplasmic reticulum Ca2+ release inhibitor and a calcium channel blocker has not yet been elucidated...