dexmedetomidine

Summary

Summary: A imidazole derivative that is an agonist of ADRENERGIC ALPHA-2 RECEPTORS. It is closely-related to MEDETOMIDINE, which is the racemic form of this compound.

Top Publications

  1. Kohli U, Pandharipande P, Muszkat M, Sofowora G, Friedman E, Scheinin M, et al. CYP2A6 genetic variation and dexmedetomidine disposition. Eur J Clin Pharmacol. 2012;68:937-42 pubmed publisher
    There is a large interindividual variability in dexmedetomidine dose requirements for sedation of patients in intensive care units (ICU)...
  2. Kimura M, Saito S, Obata H. Dexmedetomidine decreases hyperalgesia in neuropathic pain by increasing acetylcholine in the spinal cord. Neurosci Lett. 2012;529:70-4 pubmed publisher
    ..Intrathecal administration of dexmedetomidine, which is a selective ?2-adrenoceptor agonist (0.1-1...
  3. Meng Q, Xia Z, Luo T, Wu Y, Tang L, Zhao B, et al. Dexmedetomidine reduces emergence agitation after tonsillectomy in children by sevoflurane anesthesia: a case-control study. Int J Pediatr Otorhinolaryngol. 2012;76:1036-41 pubmed publisher
    To evaluate the efficacy and safety of dexmedetomidine for emergence agitation after tonsillectomy in children.
  4. Mo Y, Zimmermann A. Role of dexmedetomidine for the prevention and treatment of delirium in intensive care unit patients. Ann Pharmacother. 2013;47:869-76 pubmed publisher
    To review recent clinical studies regarding the role of dexmedetomidine for prevention and treatment of delirium in intensive care unit (ICU) patients.
  5. Adams R, Brown G, Davidson M, Fisher E, Mathisen J, Thomson G, et al. Efficacy of dexmedetomidine compared with midazolam for sedation in adult intensive care patients: a systematic review. Br J Anaesth. 2013;111:703-10 pubmed publisher
    ..often require sedatives which commonly include midazolam and the more recently developed ?2-receptor agonist, dexmedetomidine. It was our aim to compare the sedative and clinical effectiveness of dexmedetomidine vs midazolam in adults ..
  6. Shi Q, Wang H, Fang H. Dose-response and mechanism of protective functions of selective alpha-2 agonist dexmedetomidine on acute lung injury in rats. Saudi Med J. 2012;33:375-81 pubmed
    To investigate the protective functions of dexmedetomidine on lipopolysaccharide-induced acute lung injury in the lung tissues of rats. The experiment was conducted from May 2008 to December 2009 in Zhongshan Hospital, Shanghai, China...
  7. Uysal H, Cuzdan S, Kayiran O, Basar H, Fidancı V, Afyoncu E, et al. Preventive effect of dexmedetomidine in ischemia-reperfusion injury. J Craniofac Surg. 2012;23:1287-91 pubmed
    The aim of this study was to evaluate the effects of dexmedetomidine on ischemia-reperfusion injury of epigastric island flaps of rats.
  8. Erdivanli B, Altun M, Sezen O, Colakoğlu S. Anti-nociceptive, analgesic and pathohistological effects of intrathecal dexmedetomidine and bupivacaine in rats. Braz J Anesthesiol. 2013;63:183-7 pubmed publisher
    This study investigates analgesic and nociceptive effects of adding dexmedetomidine to bupivacaine neuraxial anesthesia through Tail-flick (TF) and Hot-plate (HP) tests and the pathohistological changes on spinal nerves and nerve roots ..
  9. Chen J, Jia J, Liu T, Qin M, Li W. Comparison of the effects of dexmedetomidine, ketamine, and placebo on emergence agitation after strabismus surgery in children. Can J Anaesth. 2013;60:385-92 pubmed publisher
    ..This study compared the effects of intraoperative dexmedetomidine, ketamine, and placebo on postoperative EA and POV...

More Information

Publications62

  1. Tüfek A, Kaya S, Tokgöz O, Firat U, Evliyaoglu O, Celik F, et al. The protective effect of dexmedetomidine on bupivacaine-induced sciatic nerve inflammation is mediated by mast cells. Clin Invest Med. 2013;36:E95-102 pubmed
    This study was designed to assess the correlation between the neuroprotective effect of dexmedetomidine and oxidative stress, neural inflammation and mast cell stability in rats with bupivacaine-induced sciatic nerve toxicity.
  2. Gozalo Marcilla M, Hopster K, Gasthuys F, Hatz L, Krajewski A, Schauvliege S. Effects of a constant-rate infusion of dexmedetomidine on the minimal alveolar concentration of sevoflurane in ponies. Equine Vet J. 2013;45:204-8 pubmed publisher
    b>Dexmedetomidine has been administered in the equine as a constant-rate infusion (CRI) during inhalation anaesthesia, preserving optimal cardiopulmonary function with calm and coordinated recoveries...
  3. Bekker A, Haile M, Kline R, Didehvar S, Babu R, Martiniuk F, et al. The effect of intraoperative infusion of dexmedetomidine on the quality of recovery after major spinal surgery. J Neurosurg Anesthesiol. 2013;25:16-24 pubmed publisher
    ..We hypothesized that the intraoperative administration of dexmedetomidine (DEX), a sympatholytic agent, would reduce the stress response and improve the quality of recovery in ..
  4. Afonso J, Reis F. Dexmedetomidine: current role in anesthesia and intensive care. Rev Bras Anestesiol. 2012;62:118-33 pubmed publisher
    To update and review the application of dexmedetomidine in anesthesia and intensive care. This study is a comprehensive review of clinical uses, pharmacology, pharmacokinetics, mechanism of action and adverse effects of dexmedetomidine...
  5. Zhang F, Ding T, Yu L, Zhong Y, Dai H, Yan M. Dexmedetomidine protects against oxygen-glucose deprivation-induced injury through the I2 imidazoline receptor-PI3K/AKT pathway in rat C6 glioma cells. J Pharm Pharmacol. 2012;64:120-7 pubmed publisher
    To explore the protection and the mechanism of dexmedetomidine on the oxygen-glucose deprivation (OGD) insults in rat C6 glioma cells. Cells were subjected to OGD then assessed by viability studies...
  6. Sahin T, Begec Z, Toprak H, Polat A, Vardi N, Yucel A, et al. The effects of dexmedetomidine on liver ischemia-reperfusion injury in rats. J Surg Res. 2013;183:385-90 pubmed publisher
    ..It can affect the prognosis of patients and the success of an operation. Dexmedetomidine is a selective ?2 receptor agonist...
  7. He L, Xu J, Dai R. Dexmedetomidine reduces the incidence of fentanyl-induced cough: a double-blind, randomized, and placebo-controlled study. Ups J Med Sci. 2012;117:18-21 pubmed publisher
    ..This prospective, randomized, double-blind, placebo-controlled study evaluated the effect of dexmedetomidine (DEX) pretreatment on the incidence and severity of FIC...
  8. Kiliç K, Hanci V, Selek S, Sozmen M, Kiliç N, Citil M, et al. The effects of dexmedetomidine on mesenteric arterial occlusion-associated gut ischemia and reperfusion-induced gut and kidney injury in rabbits. J Surg Res. 2012;178:223-32 pubmed publisher
    We assessed the antioxidant activity of dexmedetomidine (Dex) administered during the ischemic period in a rabbit model of mesenteric ischemia/reperfusion (I/R) injury using biochemical and histopathological methods...
  9. Ouchi K, Koga Y, Nakao S, Sugiyama K. Dexmedetomidine dose-dependently enhances local anesthetic action of lidocaine. J Oral Maxillofac Surg. 2014;72:474-80 pubmed publisher
    The combination of ?2-adrenoceptor agonists, such as dexmedetomidine (DEX) and clonidine, with local anesthetics has been found to extend the duration of peripheral nerve blocks, probably owing to the resultant local vasoconstriction in ..
  10. Mason K, Robinson F, Fontaine P, Prescilla R. Dexmedetomidine offers an option for safe and effective sedation for nuclear medicine imaging in children. Radiology. 2013;267:911-7 pubmed publisher
    To determine the safety, efficacy, and outcomes of bradycardia, hypotension, and hypertension with dexmedetomidine (DEX), a recently approved sedative used for procedural sedation that has not been described previously for pediatric ..
  11. Liu C, Zhang Y, She S, Xu L, Ruan X. A randomised controlled trial of dexmedetomidine for suspension laryngoscopy. Anaesthesia. 2013;68:60-6 pubmed publisher
    We randomly allocated 80 patients to intravenous dexmedetomidine (0.25, 0.5, or 1??g.kg(-1) ) or placebo 15?min before anaesthetic induction. Dexmedetomidine 0.5 and 1.0??g...
  12. Gu J, Chen J, Xia P, Tao G, Zhao H, Ma D. Dexmedetomidine attenuates remote lung injury induced by renal ischemia-reperfusion in mice. Acta Anaesthesiol Scand. 2011;55:1272-8 pubmed publisher
    ..The mortality of combined acute kidney injury and ALI is extremely high. Dexmedetomidine, an ?(2) adrenergic agonist, exerts potent anti-inflammatory and organoprotective effects in addition to its ..
  13. Kaskinoro K, Maksimow A, Långsjö J, Aantaa R, Jääskeläinen S, Kaisti K, et al. Wide inter-individual variability of bispectral index and spectral entropy at loss of consciousness during increasing concentrations of dexmedetomidine, propofol, and sevoflurane. Br J Anaesth. 2011;107:573-80 pubmed publisher
    ..male volunteers aged 19-30 yr were recruited and divided into three 10-volunteer groups to receive either dexmedetomidine, propofol, or sevoflurane in escalating concentrations at 10 min intervals until loss of consciousness (LOC) ..
  14. Hsing C, Lin C, So E, Sun D, Chen T, Li C, et al. ?2-Adrenoceptor agonist dexmedetomidine protects septic acute kidney injury through increasing BMP-7 and inhibiting HDAC2 and HDAC5. Am J Physiol Renal Physiol. 2012;303:F1443-53 pubmed publisher
    Bone morphogenetic protein (BMP)-7 protects sepsis-induced acute kidney injury (AKI). Dexmedetomidine (DEX), an ?(2)-adrenoceptor (?(2)-AR) agonist, has anti-inflammatory effects...
  15. Huang Z, Chen Y, Yang Z, Liu J. Dexmedetomidine versus midazolam for the sedation of patients with non-invasive ventilation failure. Intern Med. 2012;51:2299-305 pubmed
    To compare the efficacy and safety of sedation with dexmedetomidine vs. midazolam for patients with acute cardiogenic pulmonary edema and hypoxemia during the treatment of non-invasive ventilation (NIV)...
  16. Wu X, Song X, Li N, Zhan L, Meng Q, Xia Z. Protective effects of dexmedetomidine on blunt chest trauma-induced pulmonary contusion in rats. J Trauma Acute Care Surg. 2013;74:524-30 pubmed publisher
    b>Dexmedetomidine is a new and highly selective ?2-adrenoreceptor agonist with potent anti-inflammatory capacity...
  17. Peng M, Wang Y, Wang C, Chen C. Dexmedetomidine attenuates lipopolysaccharide-induced proinflammatory response in primary microglia. J Surg Res. 2013;179:e219-25 pubmed publisher
    ..It has been reported that dexmedetomidine (DEX) has a potent anti-inflammatory property...
  18. Burnside W, Flecknell P, Cameron A, Thomas A. A comparison of medetomidine and its active enantiomer dexmedetomidine when administered with ketamine in mice. BMC Vet Res. 2013;9:48 pubmed publisher
    Medetomidine-ketamine (MK) and dexmedetomidine-ketamine (DK) are widely used to provide general anaesthesia in laboratory animals, but have not been compared directly in many of these species, including rodents...
  19. Erdurmus M, Aydin B, Usta B, Yagci R, Gozdemir M, Totan Y. Patient comfort and surgeon satisfaction during cataract surgery using topical anesthesia with or without dexmedetomidine sedation. Eur J Ophthalmol. 2008;18:361-7 pubmed
    To determine the safety and efficacy of perioperative dexmedetomidine (Dex) sedation on patient comfort and surgeon satisfaction during cataract surgery under topical anesthesia.
  20. Hanci V, Yurdakan G, Yurtlu S, Turan I, Sipahi E. Protective effect of dexmedetomidine in a rat model of ?-naphthylthiourea-induced acute lung injury. J Surg Res. 2012;178:424-30 pubmed publisher
    We assessed the effects of dexmedetomidine in a rat model of ?-naphthylthiourea (ANTU)-induced acute lung injury. Forty Wistar Albino male rats weighing 200-240 g were divided into 5 groups (n = 8 each), including a control group...
  21. Lu Y, Zhang Y, Dong C, Yu J, Wong G. Preoperative dexmedetomidine prevents tourniquet-induced hypertension in orthopedic operation during general anesthesia. Kaohsiung J Med Sci. 2013;29:271-4 pubmed publisher
    This study was a double-blinded randomized control trial designed to investigate the hemodynamic effects of dexmedetomidine on prolonged tourniquet inflation...
  22. Niu X, Ding X, Guo T, Chen M, Fu S, Li Q. Effects of intravenous and intrathecal dexmedetomidine in spinal anesthesia: a meta-analysis. CNS Neurosci Ther. 2013;19:897-904 pubmed publisher
    To assess the effects of dexmedetomidine on the duration of sensory and motor block, postoperative analgesia, hypotension, bradycardia, and side effects in patients undergoing spinal anesthesia...
  23. Abdallah F, Abrishami A, Brull R. The facilitatory effects of intravenous dexmedetomidine on the duration of spinal anesthesia: a systematic review and meta-analysis. Anesth Analg. 2013;117:271-8 pubmed publisher
    Central mechanisms have been proposed to explain the prolongation of effect reported with the off-label use of dexmedetomidine as an adjuvant in local anesthetic admixtures...
  24. Lili X, Jianjun S, Haiyan Z. The application of dexmedetomidine in children undergoing vitreoretinal surgery. J Anesth. 2012;26:556-61 pubmed publisher
    b>Dexmedetomidine is a highly selective alpha-2 adrenergic agonist that has a sedative effect and has been shown to reduce anesthetic requirements...
  25. Kim J, Kim N, Lee H, Kil H. Effects of intrathecal dexmedetomidine on low-dose bupivacaine spinal anesthesia in elderly patients undergoing transurethral prostatectomy. Biol Pharm Bull. 2013;36:959-65 pubmed
    ..b>Dexmedetomidine, a selective ?2-adrenoreceptor agonist, was shown to be a potent antinociceptive agent when given ..
  26. Park H, Kim Y, Koh H, Park C, Kang S, Choi J, et al. Analgesic effects of dexmedetomidine in vincristine-evoked painful neuropathic rats. J Korean Med Sci. 2012;27:1411-7 pubmed publisher
    b>Dexmedetomidine, which is a selective ?2-adrenoceptor agonist, was recently introduced into clinical practice for its analgesic properties...
  27. Gupta N, Rath G, Prabhakar H, Dash H. Effect of intraoperative dexmedetomidine on postoperative recovery profile of children undergoing surgery for spinal dysraphism. J Neurosurg Anesthesiol. 2013;25:271-8 pubmed publisher
    ..b>Dexmedetomidine may be beneficial in these children owing to its sedative, anxiolytic, and opioid-sparing properties with ..
  28. Jia J, Chen J, Hu X, Li W. A randomised study of intranasal dexmedetomidine and oral ketamine for premedication in children. Anaesthesia. 2013;68:944-9 pubmed publisher
    We studied the effects of intranasal dexmedetomidine combined with oral ketamine for premedication in children. One hundred and sixty children aged between 2 and 6 years were randomly allocated to one of four groups: 1 ?g...
  29. Cheung C, Ng K, Liu J, Yuen M, Ho M, Irwin M. Analgesic and sedative effects of intranasal dexmedetomidine in third molar surgery under local anaesthesia. Br J Anaesth. 2011;107:430-7 pubmed publisher
    b>Dexmedetomidine (DEX) is an alpha 2-adrenoreceptor agonist, which induces sedation and analgesia. This study aimed to determine whether intranasal DEX offered perioperative sedation and better postoperative analgesia...
  30. Jakob S, Ruokonen E, Grounds R, Sarapohja T, Garratt C, Pocock S, et al. Dexmedetomidine vs midazolam or propofol for sedation during prolonged mechanical ventilation: two randomized controlled trials. JAMA. 2012;307:1151-60 pubmed publisher
    Long-term sedation with midazolam or propofol in intensive care units (ICUs) has serious adverse effects. Dexmedetomidine, an ?(2)-agonist available for ICU sedation, may reduce the duration of mechanical ventilation and enhance patient ..
  31. Xiang Q, Huang D, Zhao Y, Wang G, Liu Y, Zhong L, et al. Caudal dexmedetomidine combined with bupivacaine inhibit the response to hernial sac traction in children undergoing inguinal hernia repair. Br J Anaesth. 2013;110:420-4 pubmed publisher
    ..The current study examined whether supplementation of caudal bupivacaine with dexmedetomidine could achieve better results.
  32. Ebner L, Lerche P, Bednarski R, Hubbell J. Effect of dexmedetomidine, morphine-lidocaine-ketamine, and dexmedetomidine-morphine-lidocaine-ketamine constant rate infusions on the minimum alveolar concentration of isoflurane and bispectral index in dogs. Am J Vet Res. 2013;74:963-70 pubmed publisher
    To determine the effect of dexmedetomidine, morphine-lidocaine-ketamine (MLK), and dexmedetomidine-morphine-lidocaine-ketamine (DMLK) constant rate infusions on the minimum alveolar concentration (MAC) of isoflurane and bispectral index (..
  33. Bostankolu E, Ayoglu H, Yurtlu S, Okyay R, Erdogan G, Deniz Y, et al. Dexmedetomidine did not reduce the effects of tourniquet-induced ischemia-reperfusion injury during general anesthesia. Kaohsiung J Med Sci. 2013;29:75-81 pubmed publisher
    ..In our study, we examined the effects of dexmedetomidine on tourniquet-induced ischemia-reperfusion injury in lower extremity surgeries performed under general ..
  34. Hwang L, Choi I, Kim S, Ko I, Shin M, Kim C, et al. Dexmedetomidine ameliorates intracerebral hemorrhage-induced memory impairment by inhibiting apoptosis and enhancing brain-derived neurotrophic factor expression in the rat hippocampus. Int J Mol Med. 2013;31:1047-56 pubmed publisher
    ..b>Dexmedetomidine is an agonist for ?2?adrenoreceptors with sedative, anxiolytic, analgesic and anesthetic effects...
  35. Turan A, Dalton J, Kasuya Y, Akca O, Sessler D, Rauch S. Correlation between bispectral index, observational sedation scale, and lower esophageal sphincter pressure in volunteers using dexmedetomidine or propofol. Med Sci Monit. 2012;18:CR593-6 pubmed
    ..Subjects were given sedative infusions of increasing target plasma concentrations of dexmedetomidine or propofol. LESP and GEPG were recorded after starting each infusion phase...
  36. Akin A, Bayram A, Esmaoglu A, Tosun Z, Aksu R, Altuntaş R, et al. Dexmedetomidine vs midazolam for premedication of pediatric patients undergoing anesthesia. Paediatr Anaesth. 2012;22:871-6 pubmed publisher
    b>Dexmedetomidine, an ?(2)-receptor agonist, provides sedation, analgesia, and anxiolytic effects, and these properties make it a potentially useful anesthetic premedication...
  37. Blaudszun G, Lysakowski C, Elia N, Tramer M. Effect of perioperative systemic ?2 agonists on postoperative morphine consumption and pain intensity: systematic review and meta-analysis of randomized controlled trials. Anesthesiology. 2012;116:1312-22 pubmed publisher
    ..Thirty studies (1,792 patients, 933 received clonidine or dexmedetomidine) were included...
  38. Zhang X, Liu Z, Wen S, Li Y, Li Y, Yao X, et al. Dexmedetomidine administration before, but not after, ischemia attenuates intestinal injury induced by intestinal ischemia-reperfusion in rats. Anesthesiology. 2012;116:1035-46 pubmed publisher
    Intestinal ischemia-reperfusion (I/R) injury is a devastating complication in the perioperative period. Dexmedetomidine is commonly applied in the perioperative period...
  39. Baba Y, Kohase H, Oono Y, Fujii Abe K, Arendt Nielsen L. Effects of dexmedetomidine on conditioned pain modulation in humans. Eur J Pain. 2012;16:1137-47 pubmed publisher
    Systemic administration of dexmedetomidine (DEX; selective ?(2) -adrenoceptor agonist) is found to inhibit diffuse noxious inhibitory control in rats, now referred to as conditioned pain modulation (CPM) in humans...
  40. Bharati S, Pal A, Biswas C, Biswas R. Incidence of cardiac arrest increases with the indiscriminate use of dexmedetomidine: a case series and review of published case reports. Acta Anaesthesiol Taiwan. 2011;49:165-7 pubmed publisher
    b>Dexmedetomidine has predictable, complex, and negative cardiovascular effects that lead to additional adverse effects such as bradycardia and hypotension in up to 42% of patients and might cause profound left ventricular dysfunction and ..
  41. Zhu Y, Wang C, Chen L, Qian L, Ma L, Yu J, et al. Both PI3K/Akt and ERK1/2 pathways participate in the protection by dexmedetomidine against transient focal cerebral ischemia/reperfusion injury in rats. Brain Res. 2013;1494:1-8 pubmed publisher
    b>Dexmedetomidine (Dex) has been demonstrated to provide neuroprotection against ischemia/reperfusion (I/R) injury. However, the exact mechanism of this protection remains unknown...
  42. Abdallah F, Brull R. Facilitatory effects of perineural dexmedetomidine on neuraxial and peripheral nerve block: a systematic review and meta-analysis. Br J Anaesth. 2013;110:915-25 pubmed publisher
    ..This quantitative review examines whether perineural dexmedetomidine as a local anaesthetic (LA) adjuvant for neuraxial and peripheral nerve blocks can prolong the duration of ..
  43. Solanki S, Bharti N, Batra Y, Jain A, Kumar P, Nikhar S. The analgesic effect of intrathecal dexmedetomidine or clonidine, with bupivacaine, in trauma patients undergoing lower limb surgery: a randomised, double-blind study. Anaesth Intensive Care. 2013;41:51-6 pubmed
    ..was designed to compare the duration of analgesia and adverse effects following intrathecal administration of dexmedetomidine or clonidine, both with bupivacaine, in trauma patients...
  44. Senses E, Apan A, Kose E, Oz G, Rezaki H. The effects of midazolam and dexmedetomidine infusion on peri-operative anxiety in regional anesthesia. Middle East J Anaesthesiol. 2013;22:35-40 pubmed
    This study aimed to compare the influences ofmidazolam and dexmedetomidine infusion on anxiety scores in patients undergoing surgery with regional anesthesia...
  45. Iirola T, Ihmsen H, Laitio R, Kentala E, Aantaa R, Kurvinen J, et al. Population pharmacokinetics of dexmedetomidine during long-term sedation in intensive care patients. Br J Anaesth. 2012;108:460-8 pubmed publisher
    b>Dexmedetomidine is a highly selective and potent ?(2)-adrenoceptor agonist registered for sedation of patients in intensive care units...
  46. Yu J, Lu Y, Dong C, Zhu H, Xu R. Premedication with intravenous dexmedetomidine-midazolam suppresses fentanyl-induced cough. Ir J Med Sci. 2012;181:517-20 pubmed publisher
    ..In this study, we hypothesized that premedication with intravenous dexmedetomidine-midazolam can suppress FIC effectively...
  47. Park J, Chung H, Lee E, Jung K, Paik J, Lee K. ?2-Adrenergic agonists including xylazine and dexmedetomidine inhibit norepinephrine transporter function in SK-N-SH cells. Neurosci Lett. 2013;541:184-9 pubmed publisher
    ..Results from this investigation showed that xylazine and dexmedetomidine dose-dependently blocked [(3)H]nisoxetine binding in neuron-like SK-N-SH cells...
  48. Marhöfer D, Kettner S, Marhofer P, Pils S, Weber M, Zeitlinger M. Dexmedetomidine as an adjuvant to ropivacaine prolongs peripheral nerve block: a volunteer study. Br J Anaesth. 2013;110:438-42 pubmed publisher
    b>Dexmedetomidine is an ?-2-receptor agonist which might be used as an additive to local anaesthetics for various regional anaesthetic techniques...
  49. Degos V, Charpentier T, Chhor V, Brissaud O, Lebon S, Schwendimann L, et al. Neuroprotective effects of dexmedetomidine against glutamate agonist-induced neuronal cell death are related to increased astrocyte brain-derived neurotrophic factor expression. Anesthesiology. 2013;118:1123-32 pubmed publisher
    ..b>Dexmedetomidine, a selective agonist of ?2-adrenergic receptors, also provides neuroprotection against glutamate-induced ..
  50. Quezado Z, Groblewski J, Gelfand H, Shah R. Dexmedetomidine and proprofol in complex microlaryngeal surgery in infants. Int J Pediatr Otorhinolaryngol. 2009;73:1311-2 pubmed publisher
    We describe the case of an infant undergoing endoscopic repair of a laryngeal cleft where the combination of dexmedetomidine and propofol infusions was used as the anesthetic technique...
  51. Komasawa N, Kimura Y, Hato A, Ikegaki J. [Three successful cases of continuous dexmedetomidine infusion for the treatment of intractable delirium associated with cancer pain]. Masui. 2013;62:1450-2 pubmed
    ..three cases of successful treatment of intractable delirium associated with cancer pain with continuous dexmedetomidine (DEX) infusion. Case 1 : An 83-year-old man receiving oral oxycodone for lung cancer pain developed delirium...
  52. Bulow N, Barbosa N, Rocha J. Opioid consumption in total intravenous anesthesia is reduced with dexmedetomidine: a comparative study with remifentanil in gynecologic videolaparoscopic surgery. J Clin Anesth. 2007;19:280-5 pubmed
    To evaluate the capacity of dexmedetomidine (DEX), an alpha(2) adrenergic agonist drug, as a substitute for remifentanil (REM), a potent opioid, in total intravenous anesthesia (TIVA), in patient undergoing gynecologic videolaparoscopy...
  53. Mimuro S, Katoh T, Suzuki A, Yu S, Adachi Y, Uraoka M, et al. Deterioration of myocardial injury due to dexmedetomidine administration after myocardial ischaemia. Resuscitation. 2010;81:1714-7 pubmed publisher
    b>Dexmedetomidine is a highly selective ?-2 adrenergic agonist used perioperatively. Dexmedetomidine's cardioprotective effect after myocardial ischaemia remains unknown...